| Vice Chancellor |
 | Dr. LouAnn Woodward
Vice Chancellor for Health Affairs and Dean of the School of Medicine | Biography |
| Executive Cabinet |
 | Stacy Baldwin
Chief Integrity Officer | Biography |
 | Molly Brasfield
Chief Human Resources Officer | Biography |
 | Dr. Kristina Cherry
Chief Nursing Executive | Biography |
 | Britt Crewse
Chief Executive Officer, Adult Hospitals | Biography |
 | Dr. Guy Giesecke
Chief Executive Officer, Children’s of Mississippi | Biography |
 | Dr. Joey Granger
Associate Vice Chancellor for Research | Biography |
 | Dr. Loretta Jackson-Williams
Vice Dean for Medical Education, School of Medicine | Biography |
 | Dr. Alan Jones
Associate Vice Chancellor for Clinical Affairs | Biography |
 | Dodie McElmurray
Chief Executive Officer, Community Hospitals | Biography |
 | Dr. Scott Rodgers
Associate Vice Chancellor for Academic Affairs | Biography |
 | Marc Rolph
Executive Director of Communications and Marketing | Biography |
 | Dr. Brian Rutledge
Chief of Staff, Office of the Vice Chancellor | Biography |
 | Dr. Juanyce Taylor
Chief Diversity and Inclusion Officer | Biography |
 | William Smith
General Counsel and Chief Legal Officer | Biography |
 | Nelson Weichold
Chief Financial Officer | Biography |
 | Dr. Jonathan Wilson
Chief Administrative Officer | Biography |
| Academic Officers |
 | Dr. Angela Burrell
Interim Dean of the School of Health Related Professions | Biography |
 | Dr. Thomas Dobbs
Dean of the School of Population Health |
 | Dr. Sreenivas Koka
Dean of the School of Dentistry | Biography |
 | Dr. Joey Granger
Dean of the School of Graduate Studies in the Health Sciences | Biography |
| Dr. Loretta Jackson-Williams
Vice Dean for Medical Education, School of Medicine | Biography |
 | Dr. Leigh Ann Ross
Associate Dean for Clinical Affairs, School of Pharmacy | Biography |
 | Dr. Julie Sanford
Dean of the School of Nursing | Biography |
| Emeriti |
| Edrie J. George, MSN, EdD | Dean Emeritus of the School of Nursing |
| Buford Gilbert, DMD | Dean Emeritus of the School of Dentistry |
| Willie Hill, DDS, MS | Dean Emeritus of the School of Dentistry |
| Daniel W. Jones, MD | Vice Chancellor Emeritus for Health Affairs
Dean Emeritus of the School of Medicine |
| James E. Keeton, MD | Vice Chancellor Emeritus for Health Affairs
Dean Emeritus of the School of Medicine |
| J. Perry McGinnis, DDS | Dean Emeritus of the School of Dentistry |
| Gary Reeves, DMD | Dean Emeritus of the School of Dentistry |