| Vice Chancellor |
 | Dr. LouAnn Woodward
Vice Chancellor for Health Affairs and Dean of the School of Medicine | Biography |
| Executive Cabinet |
 | Stacy Baldwin
Chief Integrity Officer | Biography |
 | Dr. Lee Bidwell
Associate Vice Chancellor for Research | Biography |
 | Dr. Kristina Cherry
Chief Nursing Executive | Biography |
 | Dr. Caroline Compretta
Assistant Vice Chancellor for Research | Biography |
 | Britt Crewse
Chief Executive Officer, Adult Hospitals | Biography |
 | Dr. Lisa Didion
Chief Medical Officer | Biography |
 | Dr. Natalie Gaughf
Assistant Vice Chancellor for Academic Affairs | Biography |
 | Dr. Guy Giesecke
Chief Executive Officer, Children’s of Mississippi | Biography |
 | Dr. Sara Gleason
Assistant Vice Chancellor for Clinical Affairs | Biography |
 | Dr. Loretta Jackson-Williams
Vice Dean for Medical Education, School of Medicine | Biography |
 | Dr. Alan Jones
Associate Vice Chancellor for Clinical Affairs | Biography |
 | Frank Lenoir
Chief Human Resources Officer | Biography |
 | Dodie McElmurray
Chief Executive Officer, Community Hospitals | Biography |
 | Dr. Scott Rodgers
Associate Vice Chancellor for Academic Affairs | Biography |
 | Marc Rolph
Executive Director of Communications and Marketing | Biography |
 | Dr. George Russell
Chief Executive Officer, University Physicians | Biography |
 | Dr. Brian Rutledge
Chief of Staff, Office of the Vice Chancellor | Biography |
 | Jennifer Sinclair
Chief Financial Officer | Biography |
 | William Smith
General Counsel and Chief Legal Officer | Biography |
 | Dr. Juanyce Taylor
Chief Diversity and Inclusion Officer | Biography |
 | Dr. Jonathan Wilson
Chief Administrative Officer | Biography |
 | Kevin Yearick
Chief Information Officer |
| Academic Officers |
 | Dr. Thomas Dobbs
Dean of the School of Population Health | Biography |
 | Dr. John C. “Jay” Garner
Dean of the School of Health Related Professions | Biography |
| Dr. Loretta Jackson-Williams
Vice Dean for Medical Education, School of Medicine | Biography |
 | Dr. Sreenivas Koka
Dean of the School of Dentistry | Biography |
 | Dr. Tina Martin
Interim Dean of the School of Nursing | Biography |
 | Dr. Sydney Murphy
Dean of the School of Graduate Studies in the Health Sciences | Biography |
 | Dr. Donna Strum
Dean of the School of Pharmacy |