Project Baby Bear (Led by Rady Children's and funded by the State of California) provided rapid WGS for infants hospitalized in intensive care while yielding life-changing benefits and saving $2.5 million in medical costs. Under the 18-month program, the genetic code of 178 critically ill babies at five hospitals across the state was sequenced to diagnose and guide personalized care resulting in shorter hospital stays, fewer unnecessary procedures with better outcomes for the children and their families.