Jason Engel (G3)
Undergraduate Degree/Field of Study: Biomedical Engineering
Undergraduate Institution: Mississippi State University
Field of Study/Interests: Development of novel therapeutics to protect microvasculature in ischemic kidney disease. Investigation of the role of immune infiltration in chronic renal microvascular injury and recovery.
Honors/Awards: A. Wallace Conerly, M.D. Scholarship; High Impact Paper: Basic Science - Hypertension Winter 2019; Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award; APS Renal Section Predoctoral Excellence in Renal Research Award Finalist; Alpha Omega Alpha Medical Honor Society
National/Local Committee Membership/Leadership Positions: Alpha Omega Alpha Research Award Committee Chair
Funded Fellowship Application: American Heart Association Pre-doctoral Fellowship (19PRE34380314) entitled “Novel Therapeutic Strategy for Treatment of Renovascular Disease”
Published Papers as MD/PhD Student:
Engel JE, Chade AR. Macrophage polarization in chronic kidney disease: a balancing act between renal recovery or decline? Am J Physiol Renal Physiol. 314: F1409-F1413, 2019.
Engel JE, Guise E, Williams M, Bidwell GL, Chade AR. Targeted VEGF therapy induces long-term renal recovery in chronic kidney disease via macrophage polarization. Hypertension. 74: 1113-1123,2019 *Selected as High Impact Paper-Basic Science 2019
Guise E, Engel JE, Williams ML, Mahdi F, Bidwell GL, Chade AR. Biopolymer-delivered vascular endothelial growth factor improves renal outcomes following revascularization. Am J Physiol Renal Physiol. 316: F1016-F1025,2019.
Chade AR, Williams M, Engel JE, Guise E, Harvey T. A Translational model of chronic kidney disease in swine. Am J Physiol Renal Physiol. 315:F364-F373, 2018.
Harvey TW, Engel JE, Chade AR (2016). Vascular endothelial growth factor and podocyte protection in chronic hypoxia: Effects of endothelin-A receptor antagonism. Am J Nephrol. 43:74-84,2016
Hannah Turbeville (G3)
Undergraduate Degree/Field of Study: Medical Laboratory Science
Undergraduate Institution: The University of Southern Mississippi
Field of Study/Interests: Developmental programming effects of preeclampsia and potential therapeutic targets with particular interest in resultant hypertension and chronic kidney disease
Honors/Awards: A. Wallace Conerly Scholarship; Portland Press Predoctoral Research Award Finalist; Alpha Omega Alpha Honor Society; Meyer and Genevieve Falk Endowment Award; Three-time ASN travel award recipient
National/Local Committee Membership/Leadership Positions: American Physician Scientists Association Partnerships Committee Chair; Local APSA Vice-President/Institutional Representative; SOM Career Day Planning Committee; Trainee Representative for UMMC Group on Women in Medicine and Science; SOM Admissions Ambassador; Station Lead for Physiology Understanding Day at MS Children’s Museum.
Funded Fellowship Application (Title and Award Number): National Institutes of Health NSRA Pre-doctoral Fellowship for Combined Degree Students (F30DK118864) entitled “Therapeutic Role of Intrapartum PDE-5 Inhibition on Vascular and Renal Function in Offspring of Preeclamptic Pregnancy.”
Published Papers as MD-PhD Student:
Turbeville HR, Taylor EB, Garrett MR, Didion S, Ryan MJ, Sasser JM. Preeclamptic pregnancy exacerbates postpartum renal injury despite lack of long-term blood pressure difference in the Dahl salt sensitive rat. Hypertension. 73:650-658,2019.
Taylor EB, Barati MT, Powell DW, Turbeville HR, Ryan MJ. Plasma cell depletion attenuates hypertension in an experimental model of autoimmune disease. Hypertension. 71:719-728,2018.
Interests/Hobbies: Medical education, medical missions, travel, scuba diving, all things Disney
Talal Younes (G3)
Undergraduate Degree/Field of Study: Biology and Chemistry
Undergraduate Institution: William Carey University
Field of Study/Interests: Pediatric neuro-oncology; developmental origins of pediatric tumors; vascular effects of preeclampsia; experimental therapeutics for preeclampsia
Honors/Awards: Alpha Omega Alpha Honor Medical Society; Gold Humanism Honor Society; American College of Physicians Young Achiever
National/Local Committee Membership/Leadership Positions: Physiologists-in-Training Group Coordinator
Funded Fellowship Application: American Heart Association Predoctoral Fellowship (18PRE34050024): “The Role of Anti-Angiogenic Factors in Cerebrovascular Dysfunction of Preeclampsia.”; St. Baldrick’s Foundation Summer Fellowship (Co-PI): “Whole Exome Sequencing of Disseminated Pilocytic Astrocytoma.”; UMMC Pediatrics Intradepartmental Discovery Support Program (Co-PI): “Molecular Characterization of Disseminated Pilocytic Astrocytoma.”
Duncan JW, Younes ST, Hildebrandt E, Ryan MJ, Granger JP, Drummond HA. Tumor necrosis factor-alpha impairs cerebral blood flow control in pregnant rats: Role of TNF-alpha on vascular beta-epithelial sodium channel. Am J Physiol Heart Circ Physiol. In Revision.
Younes ST, Maeda KJ, Sasser J, Ryan MJ. The glucagon-like peptide 1 receptor agonist liraglutide attenuates placental ischemia-induced hypertension. Am J Physiol Heart Circ Physiol. 318:H72-77,2020. * Selected for the American Physiological Society APSselect, a monthly collection from APS that highlights the best recently published articles in physiological research
Younes ST, Ryan MJ. Pathophysiology of cerebral vascular dysfunction in pregnancy-induced hypertension. Curr Hypertens Rep. 21:53,2019.
Younes ST. Shift: A medical student’s reflections on the practice of medicine and nursing. Am J Med Sci. 355:402-403,2018.
Interests/Hobbies: Philosophy, theology, apologetics, reading, gardening
Meredith Cobb (G2)
Undergraduate Degree/Field of Study: BS in Biochemistry
Field of Study/Interests: My research is in nephron deficiency and its potential role in the development of diabetic kidney disease. My medical specialty interest is Internal Medicine-Pediatrics (Med-Peds).
Honors/Awards: A. Wallace Conerly Scholarship; Poster Award Winner, American Heart Association Hypertension Scientific Sessions 2019; American Society of Nephrology Kidney STARS 2018 and 2019; The Jackson Fund Scholarship for The 60th McKusick Short Course Associated Student Body President’s Award; University of Southern Mississippi Student Hall of Fame
National/Local Committee Membership/Leadership Positions:
Inaugural Physician Scientist Interest Day for Underrepresented Students Event Co-Chair; American Physiological Society Science Policy Committee Trainee member; Southeastern Medical Scientist Symposium 2019 External Event Committee; UMMC Associate Student Body Secretary; UMMC Admissions Ambassador; American Physician Scientist Association Institutional Representative; Carl G. Evers Society
Showmaker K, Cobb MB, Johnson AC, Garrett MR. Whole genome sequencing and novel candidate genes for CAKUT an altered nephrogenesis in the HSRA rat. Physiol Genomics. 52:56-70,2020.
Interests/Hobbies: Cycling and watching funny TV shows with my husband; being a mom to my three year old daughter.
Ezekiel Gonzalez-Fernandez (G2)
Undergraduate Degree/Field of Study: Chemistry
Undergraduate Institution: California State University - Long Beach
Field of Study/Interests: Alzheimer’s disease and related dementias
Honors/Awards: A. Wallace Conerly Scholarship; Henderson Award; RISE Fellow; American Heart Association Pre-doctoral Fellowship
President, local Chapter American Physician Scientists Association
Fan L, Wang S, He X, Gonzalez-Fernandez E, Lechene C, Fan F, Roman RJ. Visualization of intrarenal distribution of capillary blood flow. Physiol Rep. 7:e14065,2019.
Lv W, Fan F, Wang Y, Gonzalez-Fernandez E, Wang C, Yang L, Booz GW, Roman RJ. Therapeutic potential of microRNAs for the treatment of renal fibrosis and CKD. Physiol Genomics. 50:20-34,2018.
Shekhar S, Wang S, Mims PN, Gonzalez-Fernandez E, Zhang C, He X, Liu CY, Lv W, Wang Y, Huang J, Fan F. Impaired cerebral autoregulation: a common neuropathy in diabetes may play a critical role in diabetes-related alzheimer’s disease. Curr Res Diabetes Obes J. 2:e555587,2017.
Interests/Hobbies: Kayak fishing, tea parties with daughters, reading the Bible
Jamarius Waller (G2)
Undergraduate Degree/Field of Study: B.A Biochemistry
Undergraduate Institution: The University of Mississippi
Field of Study/Interests: Medical: Pediatrics and therapeutic drug development and drug pharmacokinetics
Honors/Awards: A. Wallace Conerly Scholarship; Martin Frank Diversity Fellowship Recipient
National/Local Committee Membership/Leadership Positions: Mentor for Undergraduate Students; Local American Physician Scientist Association Chapter; UMMC Admissions Ambassador; Organizer-President
UMMC Bi-annual African American Visit Day; Treasuer and Mentorship Chairman, Local American Physician Scientist Association Chapter; Treasurer,
UMMC Student National Medical Association; Graduate Student Ambassador, APS
Funded Fellowship Application: NIH F31 Fellowship: “The use of a biopolymer-fused form of VEGF-B for the treatment of Preeclampsia.”
Published Papers as MD-PhD Student:
Kuna M, Waller JP, Logue OC, Bidwell GL 3rd. Polymer size affects biodistribution and placental accumulation of the drug delivery biopolymer elastin-like polypeptide in a rodent pregnancy model. Placenta. 72-73:20-27,2018
Bidwell GL 3rd, Mahdi F, Shao Q, Logue OC, Waller JP, Reese C, Chade AR. A kidney-selective biopolymer for targeted drug delivery. Am J Physiol Renal Physiol. 312:F54-F64,2017.
Interests/Hobbies: Mentoring community youth; spending time with my family; Dungeons & Dragons; Chess
Jacob Pruett (G1)
Undergraduate Degree/Field of Study: Biochemistry
Current Field of Study/Interests: Polycystic Ovary Syndrome (PCOS), Sodium-glucose co-transporters, endocrinology
Honors/Awards: A. Wallace Conerly Scholarship; Virendra B Mahesh Award of Excellence in Endocrinology; Best Oral Presentation: Southeast Medical Scientist Symposium; Kidney STARS Travel Grant; Alpha Omega Alpha (AOA); Gold Humanism Honor Society
National/Local Committee Membership/Leadership Positions: Chair of AOA Research Award Committee (2019-2020); Co-Chair of GHHS Mini-Projects Committee (2019-2020); Current member of: the American Society of Nephrology, the American Physician Scientists Association, and the American Physiological Society
Interests/Hobbies: Traveling; Spanish; video games
Shelley Rae Edwards (M2)
Undergraduate Degree/Field of Study: Neuroscience
Undergraduate Institution: Millsaps College
Field of Study/Interests: Neuroscience
Honors/Awards: A. Wallace Conerly Scholarship
National/Local Committee Membership/Leadership Positions: APSA