Intramural Research Support Program

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IRSP Translational Research and Science Request for Proposals

UMMC Research is pleased to announce the release of a funding announcement intended to stimulate research across a wide range of translational topics. The overall goal of the Translational Research and Science IRSP is to encourage faculty in basic, preclinical, clinical, and implementation science/public/community health arenas at UMMC to initiate studies that involve either (a) carrying a discovery from one arena to another, with the goal of directly improving human health, or (b) advance and improve any step in the process of translating discoveries to treatments. A key goal of this initiative is to support research that holds promise for extramural funding by NIH or other major funding sources.

Background

The National Institutes of Health defines “translational research” as the process of turning research findings and observations in the laboratory, clinic, and community into interventions that improve the health of individuals and the public. This experimental strategy is sometimes referred to as “bench-to-bedside” and “bedside-to-community” research. Translational research may be bidirectional, with clinical and/or community science informing basic/preclinical research. “Translational science”, on the other hand, is the field of investigation that seeks to understand the scientific and operational principles underlying each step of the translational process.

Given these broad concepts, we are encouraging UMMC teams to submit proposals in any area advancing translational research and science. For guidance, the applicants should consider two conceptual platforms:

Forward Translation: Moving findings obtained with basic/preclinical, human laboratory, and/or dissemination/implementation research into proof-of-concept human studies, clinical trials, populations with targeted diseases/disorders, and/or health practices.

Reverse Translation: Moving findings and/or observations from clinical settings into the laboratory and/or targeted human studies in order to identify mechanisms and/or improve treatment efficacy.

A requirement of this application is a commitment to Team Science. The applicant must assemble a team that facilitates the translational goals of the project, ideally consisting of a mix of scientists and clinicians.

Budget Information

It is anticipated that multiple awards will be made. Funding may be requested up to $60,000 for one year projects. Funds can be requested for research supplies and services, technical assistance, publication expenses, equipment, animal costs, some categories of travel, research participant compensation, and extramural consultant fees. Funds for faculty salary and administrative support will not be considered. Student stipends may be considered.

Travel to collect data or meet with local/regional community or academic partners will be funded as will travel to a professional meeting if evidence is provided that the research results will be formally presented.

Review Process

Reviews will be completed by ad-hoc review panels of UMMC faculty with expertise in the scientific topic.

Reviewers will evaluate each application for the potential to advance understanding of the stated problem and the significance of the stated problem. Consideration will be given to those applications that provide evidence for success in obtaining peer-reviewed extramural research funding. Applicants are encouraged to include in their proposals a clearly defined path to extramural funding by outlining which agencies and funding programs they might target in subsequent extramural funding applications and why their project is a good fit for such funding.

In addition to the potential for future peer-reviewed funding, recommendations for funding will be based upon: potential impact, innovation, scientific merit, interdisciplinary nature of the project, and commitment to team science.

The NIH scoring system from 1 (exceptional) to 9 (poor) will be used for scoring purposes. It is expected that each application will be reviewed and scored by 2-3 assigned reviewers.

Eligibility

Applicants (PIs) are limited to investigators who are full-time faculty of UMMC. Other key members of the research team (co-investigator; consultants) are not required to be UMMC full-time faculty. Faculty at the Assistant Professor or early Associate Professor level are especially encouraged to apply.

Applicants who have received a NIH R01-type grant (or equivalent from other sources) as a Principal Investigator are not eligible for this award unless they demonstrate that the proposal focuses upon a new (unfunded) area of research.

While a faculty member may be involved in more than one application for this initiative, they may submit only one application in the PI or co-PI role.

Application Information

Preliminary data may be included but are not essential for this pilot work. However, information related to the feasibility of completing the proposed work is welcome.

Research projects involving human subjects, animals, or hazardous materials can be submitted without the relevant approvals in place. However, dates for such review should be in place and approvals must be obtained by the appropriate University committee before funds are released.

Application Timeline

Applications will be accepted until Monday, April 18th, 2022, 11:59 pm.

Submission Link:  Intramural Research Support Program Application

Anticipated notification date: June 1st, 2022

Period of Award: July 1, 2022 – June 30, 2023. Unless an extension is requested in writing 10 days prior to the end date, any unexpended balance will be returned to the main account.

Final Progress Report: October 1, 2022

The final progress report will include an update of presentations and publications from this funded pilot grant and information related to the submission of “next step” research for extramural funding based upon the funding for this initiative

It is expected that each funded team will present their results at a UMMC seminar series or special meeting at the completion of the project.

Questions?

Questions related to the application forms or process itself (problems entering data, “how to” enter categories of information) should be directed to Cari Fowler

Other questions (where or if a given project “fits” into one of the three research programs; whether focus of the project is relevant to translational research; questions about the review process) may best be directed to one of the following: James Rowlett or Michael Hall