Center for Computational Medicine

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  • Clemmer JS, Pruett WA, Hester RL, Iliescu R, Lohmeier TE. Role of the Heart in Blood Pressure Lowering During Chronic Baroreflex Activation: Insight from an in Silico Analysis. Am J Physiol Heart Circ Physiol. 2018 Jul 13. doi: 10.1152/ajpheart.00302.2018
  • Clemmer JS, Hester RL, Pruett WA. Simulating a virtual population's sensitivity to salt and uninephrectomy. Interface Focus. 2018 Feb 6;8(1):20160134.PMID: 29285341
  • Sims CR 3rd, Delima LR, Calimaran A, Hester R, Pruett WA. Validating the Physiologic Model HumMod as a Substitute for Clinical Trials Involving Acute Normovolemic Hemodilution. Anesth Analg. 2018 Jan;126(1):93-101. PMID: 28863020
  • Blair ET, Clemmer JS, Harkey HL, Hester RL, Pruett WA. Physiological Mechanisms of Water and Electrolyte Disturbances Following Transsphenoidal Pituitary Surgery. World Neurosurg. 2017 Aug 7.  PMID: 28797976
  • Clemmer JS, Pruett WA, Coleman TG, Hall JE, Hester RL. Mechanisms of blood pressure salt sensitivity: New insights from mathematical modeling. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1;312(4):R451-R466.PMID: 27974315
  • Pruett WA, Clemmer JS, Hester RL. Validation of an integrative mathematical model of dehydration and rehydration in virtual humans, Physiol Rep. 2016 Nov;4(22). pii: e13015. PMID: 27899683
  • Barnes SL, Bukoski A, Kerby JD, Llerena L, Armstrong JH, Strayhorn C and University of Missouri Combat Casualty Training Consortium. Live tissue versus simulation training for emergency procedures: Is simulation ready to replace live tissue? Surgery. 2016 Oct;160(4):997-1007. doi: 10.1016/j.surg.2016.04.044.  PMID: 27506866
  • Pruett WA, Hester RL, The Creation of Surrogate Models for Fast Estimation of Complex Model Outcomes. PLoS One. 2016 Jun 3;11(6):e0156574. PMID: 27258010
  • Hester RL, Pruett WA. Use of Computer Simulations to Understand Female Physiology: Where's the Data? Physiology (Bethesda). 2015 Nov;30(6):404-5
  • Lerant AA, Hester RL, Coleman TG, Phillips WJ, Orledge JD, Murray WB. Preventing and Treating Hypoxia: Using a Physiology Simulator to Demonstrate the Value of Pre-Oxygenation and the Futility of Hyperventilation. Int J Med Sci. 2015 Jul 23;12(8):625-32.
  • Zhang, Song, Pruett, WA, and Hester R. "Visualization and classification of physiological failure modes in ensemble hemorrhage simulation", Proc. SPIE 9397, Visualization and Data Analysis 2015, February 8, 2015, San Francisco, CA; doi:10.1117/12.2080136;
  • Pruett, W, Husband LD and Hester RL. A Decision Support System Predicting Imminent Cardiovascular Shock.  Paper # 14343 IITSEC Conference 2014
  • Pruett WA, and Hester RL Parathyroid hormone secretion by multiple distinct cell populations, a time dynamic mathematical model Physiological Reports Volume 2, Issue 2, February 2014
  • Karaaslan F, Denizhan Y, Hester RL. A Mathematical Model of Long-Term Renal Sympathetic Nerve Activity Inhibition During an Increase in Sodium Intake. Am J Physiol Regul Integr Comp Physiol. 2014;306(4):R234-47 PMID: 24285363
  • K. Wu, J. Chen, W. A. Pruett, and R. L. Hester. HumMod Browser: An Exploratory Visualization Tool for the Analysis of Whole-Body Physiology Simulation Data. IEEE Symposium on Biological Data Visualization. October, 2013
  • Pruett WA, Husband L, Husband G, Dakhlalla M, Bellamy K, Coleman, T, and Hester RL. A Population Model of Integrative Cardiovascular Physiology, PLOS One, 2013 Sep 13;8(9):e74329. PMID: 24058546
  • Pruett WA, Hester RL, Coleman TG. The apparent hysteresis in hormone-agonist relationships. J Theor Biol. 2011 Dec 3;296C:1-5
  • Walters DK, Burgreen GW, Lavallee DM, Thompson DS, Hester RL., Efficient, physiologically realistic lung airflow simulations. IEEE Trans Biomed Eng. 2011;58(10):3016-9.
  • Hester R, Brown A, Husband L, Iliescu R, Pruett WA, Summers RL and Coleman T (2011). HumMod: A modeling environment for the simulation of integrative human physiology. Front. Physio. 2:12. doi: 10.3389/fphys.2011.00012 PMID: 21647209
  • Hester RL, Iliescu R, Summers RL, Coleman TG. Systems Biology and Integrative Physiological Modeling. J Physiol. 2011;589(Pt 5):1053-60. PMID: 21135044
  • Burgreen GW, Hester R, Soni B, Thompson D, Walters DK, Walters K. DigitalLung: application of high-performance computing to biological system simulation. Adv Exp Med Biol. 2010;680:573-84.
  • Hester RL, RL Summers, R Iliescu, J Ester, and TG Coleman. DigitalHuman (DH): An Integrative model of Human Physiology, NASA/CP-2010-216205 MODSIM World Conference, p129-134, 2010.
  • Summers RL, Coleman TG, Hester RL. An analysis of the interface between lunar habitat conditions and an acclimatized human physiology as defined by the Digital Astronaut Program. Lunar Editor:  Haym Benaroya. CRC Press 2010; 233-240,  ISBN:  9781420083323.
  • Summers RL, Ward KR, Witten T, Convertino VA, Ryan KL, Coleman TG, Hester RL. Validation of a computational platform for the analysis of the physiologic mechanisms of a human experimental model of hemorrhage. Resuscitation. 2009;80:1405-10.
  • Abram SR, Hodnett BL, Summers RL, Coleman TG, Hester RL. Quantitative Circulatory Physiology: an integrative mathematical model of human physiology for medical education. Adv Physiol Educ. 2007 Jun;31(2):202-10.