Natalia M. Mathieu

PhD Candidate – Physiology Department

1624 N 116th St Apt 1, Wauwatosa WI - 53226

Cell Phone: (507) 2714059 • E-mail: nmarin@mcw.edu

EDUCATION

6/2019 – Present
Ph.D. (Physiology); Physiology Department, Medical College of Wisconsin, Milwaukee, USA

1/2013 – 12/2017
B.S. (Biomedical Engineering); University EIA-University CES, Medellin, Colombia.

PROFESSIONAL EXPERIENCE

6/2018 – 6/2019
Post-Baccalaureate Research Fellow (Advisor: Gary C. Sieck, Ph.D.); Department of Biomedical Engineering and Physiology, Mayo Clinic, Rochester, MN

1/2017 – 6/2017
Undergraduate Research Fellow; (Advisor: Gary C. Sieck, Ph.D.); Department of Biomedical Engineering and Physiology, Mayo Clinic, Rochester, MN

1/2017 – 12/2017
Undergraduate Research Fellow; (Advisor: Martha Londono, Ph.D.); Department of Biomedical Engineering, University EIA and University CES, Medellin, Colombia

RESEARCH GRANTS

1/2022 – American Heart Association Predoctoral Fellowship, 22PRE898004

HONORS AND AWARDS

PROFESSIONAL MEMBERSHIPS

2022 – present
National Science Policy Network

2021 – present
American Heart Association

2019 – present
American Physiological Society

PUBLICATIONS

Natalia M. Mathieu, Pablo Nakagawa, Connie C. Grobe, John J. Reho, Daniel T. Brozoski, Ko-Ting Lu, Kelsey Wackman, McKenzie Ritter, Jeffrey Segar, Justin L. Grobe and Curt D. Sigmund. β-Arrestin-2 Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation. Hypertension. In press

Vanessa Oliveira, John J. Reho, Kirthikaa Balapattabi, McKenzie Ritter, Natalia M. Mathieu, Megan A. Opichka, Ko- Ting Lu, Connie C. Grobe, Sebastiao D. Silva, Jr., Kelsey K. Wackman, Pablo Nakagawa, Jeffrey L.Segar, Curt D. Sigmund, and Justin L. Grobe. Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex- dependent effects upon intake bahviors and energy homeostasis in C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jul.

Vanessa Oliveira, Ruth A Riedl, Kristin E. Claffin, Natalia M. Mathieu, McKenzie Ritter, Kirthikaa Balapattabi, Kelsey K. Wackman, John J. Reho, Daniel T. Brozoski, Donald A. Morgan, Huxing Cui, Kamal Rahmouni, Colin M.L. Burnett, Pablo Nakagawa, Curt D. Sigmund, Lisa L. Morselli and Justin L. Grobe. Melanocortin MC4R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. Physiol Genomics. 2022 Jun 1;54(6):196-205.

Mario Zanaty, Fernando A.C. Seara, Pablo Nakagawa, Guorui Deng, Natalia M. Mathieu, Kirthikaa Balapattabi, Sadashiva S. Karnik, Justin L. Grobe, Curt D. Sigmund. B-Arrestin-Biased Agonist Targeting the Brain AT1R (Angiotensin II type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. 2021 Feb; 77(2):420-431.

Philippe Delmotte, Natalia Marin Mathieu, Y.S. Prakash and Gary C. Sieck. TNFα Induces Mitochondrial Fragmentation and Biogenesis in Human Airway Smooth Muscle. Am J Physiol Lung Cell Mol Physiol. 2021 Jan; 1;320(1):L137-L151. 

Natalia Marin Mathieu*, Matthew J. Fogarty*, Carlos B. Mantilla and Gary C. Sieck. Aging Reduces Succinate Dehydrogenase Activity in Rat Type IIx/IIb Diaphragm Muscle Fibers. J Appl Physiol. 2020 Jan; 1;128(1):70-77. *co-first author.

ABSTRACTS

National

Natalia M. Mathieu, Pablo Nakagawa, Justin L. Grobe and Curt D. Sigmund. Non-Canonical AT1R/β-Arrestin2 Activation in Brain as a Regulator of Blood Pressure. Council on Hypertension, AHA. San Diego, CA. Sept 2022 [Podium Presentation]

Natalia M. Mathieu, Pablo Nakagawa, Justin L. Grobe and Curt D. Sigmund. Role of β-Arrestin as a Regulator of Fluid Homeostasis and Blood Pressure. Experimental Biology 2022. Phyladelphia, PA. [Podium Presentation]

Pablo Nakagawa, Daniel Brozoski, Natalia M. Mathieu, Ko-Ting Lu, Javier Gomez, John Reho, Shi Fang, Jeffrey Segar, Justin L. Grobe, and Curt D. Sigmund. Deletion of Prorenin Receptor in the Rostral Ventrolateral Medulla Results in Biphasic and Sex-Dependent Pressor Responses in Deoxycorticosterone Acetate-salt Hypertension. Experimental Biology. Phyladelphia, PA.

Natalia M. Mathieu, Pablo Nakagawa, Justin L. Grobe, Curt D. Sigmund. Non-Canonical AT1R/ β-Arrestin Activation in Brain as a Regulator of Fluid Homeostasis and Blood Pressure. Council of Hypertension [e-Podium Presentation]

Pablo Nakagawa, Daniel Brozoski, Natalia M. Mathieu, Ko-Ting Lu, Javier Gomez, John Reho, Shi Fang, Jeffrey Segar, Justin L. Grobe, and Curt D. Sigmund. Biphasic and Sex-Dependent Roles of the Prorenin Receptor in the Rostral Ventrolateral Medulla in Mice Subjected to Deoxycorticostirone Acetate-salt Hypertension. Council of Hypertension Virtual Meeting 2021.

Natalia Marin Mathieu, Preethiya Seekar, Xujiao Chen, Philippe Delmotte and Gary C. Sieck. Effect of TNFα on Mitochondrial Function and Mitochondrial Biogenesis in Human Airway Smooth Muscle. Experimental Biology 2019. Orlando, FL.

Natalia Marin Mathieu, Matthew J. Fogarty, Carlos B. Mantilla and Gary C. Sieck. Aging effects on oxidative capacity in type-identified diaphragm muscle fibers. Experimental Biology 2019. Orlando, FL.

John Yap, Xujiao Chen, Natalia Mathieu Marin, Philippe Delmotte and Gary C. Sieck. TNFα Induces Endoplasmic Reticulum Stress in Human Airway Smooth Muscle Cells. American Thoracic Society Meeting 2019. Dallas, TX.

Natalia Mathieu Marin, Xujiao Chen, Philippe Delmotte and Gary C. Sieck. TNFα Increases Mitochondrial Biogenesis in Human Airway Smooth Muscle. American Thoracic Society Meeting May 2019 Dallas, TX.

Natalia Marín Mathieu, Philippe Delmotte, and Gary C. Sieck. TNFα Induces ER Stress with downstream effect on Mitochondrial Fragmentation and Mitochondrial Biogenesis in Human Airway Smooth Muscle Cells. BMES Annual Meeting 2017. Phoenix, AZ

Institutional

Natalia M. Mathieu, Pablo Nakagawa, Justin L. Grobe, Curt D. Sigmund. Role of β-Arrestin in Mediating Drinking Response Downstream of the AT1R. Cardiovascular Center Research Retreat 2021. Milwaukee, WI.

Natalia M. Mathieu, Pablo Nakagawa, Justin L. Grobe and Curt D. Sigmund. Role of β-Arrestin in mediating drinking response downstream of the AT1R. Cardiovascular Center Virtual Research Retreat 2021. Medical College of Wisconsin, Milwaukee, WI.

Natalia M. Mathieu, Pablo Nakagawa, Justin L. Grobe and Curt D. Sigmund. Role of β-Arrestin in mediating drinking response. 30^th Annual Graduate School & Office of Postdoctoral Education 2020. Medical College of Wisconsin, Milwaukee, WI.

Natalia Marín Mathieu, Philippe Delmotte, and Gary C. Sieck. TNFα Induces Mitochondrial Fragmentation and Mitochondrial Biogenesis in Human Airway Smooth Muscle Cells. Department of Physiology & Biomedical Engineering Summer Research Symposium 2017. Mayo Clinic, Rochester, MN.

LEADERSHIP POSITIONS

6/2022 – Present
Physiology Student Representative, Medical College of Wisconsin, Milwaukee, WI

6/2021 – Present
Graduate and Medical School International Student Representative, Medical College of Wisconsin, Milwaukee, WI

8/2021 – Present
Student Health Science Conference Committee, Medical College of Wisconsin, WI

8/2022 – Present
Student Wellness Committee, Medical College of Wisconsin, WI

VOLUNTEERING AND ADVOCACY

6/2022 – Present
Graduate School Science Policy Group, Medical College of Wisconsin, Milwaukee, WI

7/2022 
PhD Career Advice Panelist. Post-baccalaureate Research Education Program, Mayo Clinic, Rochester, MN

6/2020 – Present
Graduate Student Mentor; Graduate School, Medical College of Wisconsin, Milwaukee, WI

8/2019 – 8/2020
Middle School Tutor Volunteer, Christ King Catholic Church, Milwaukee, WI

8/2018 – 5/2019
Middle School Tutor Volunteer, St. John Catholic Church, Rochester, MN

LANGUAGE PROFICIENCY

Spanish: Native

English: Advanced