Clayton T. Brady

University at Buffalo, Jacobs School of Medicine and Biomedical Science (JSMBS)

Buffalo, NY

I am currently an M.D./Ph.D. candidate in the department of Physiology and Biophysics. For my thesis research, I am investigating the role of the electrogenic sodium/bicarbonate co-transporter (NBCe1) in kidney and heart. Dr. Mark Parker, principal investigator.

June 2018 – Present

(Doctoral candidacy – August 26, 2020)

ASN Kidney TREKS Program

Mount Desert Island Biological Laboratory, Bar Harbor, ME

Week long, immersive, short course covering aspects of classic experimental nephrology. Directed by Dr. Mark Zeidel.

June 9, 2018 – June 16, 2018

Brockport Zebrafish Laboratory

Brockport, NY

Independent research conducted during my undergraduate education. We investigated the role of the calcium-activated chloride channel, Anoctamin-1, in gastrointestinal transit regulation utilizing Zebrafish as a model system. Dr. Adam Rich, principal investigator.

September 2013 – May 2017

Mayo Clinic Summer Undergraduate Research Fellow

Rochester, MN

I completed two ten-week summer research fellowships at the Mayo Clinic. My project involved validating and modifying a cyanide-nitroprusside assay for clinical use in monitoring patient’s predisposed/diagnosed with cystinuria. Dr. John Lieske, principal investigator.

May 25 - August 1, 2015

May 31 - August 6, 2016

Alsufayan TA, Myers EJ, Quade BN, Brady CT, Marshall A, Haque N, Duffey ME,

Parker MD. Revisiting the Role of Ser982 Phosphorylation in Stoichiometry Shift of the Electrogenic Na⁺/qHCO3- Cotransporter NBCe1. International Journal of Molecular Sciences. 2021;22(23):12817. doi:10.3390/ijms222312817

November, 2021

Wilson EM, Lipp SN, Brady CT, Ishibe S, Romero MF. Feeding the kidney researcher pipeline through R25-NIDDK funded summer undergraduate research fellowships: a student perspective. Kidney360. (2021) doi:10.34067/KID.0001272021 (perspective).

October, 2021

Brady C. Ammonia and bicarbonate: potential mechanisms underlying the benefits of alkali therapy in chronic kidney disease. Renal Fellow Network – Basic Science Series https://www.renalfellow.org/2021/04/19/ammonia-and-bicarbonate-potential-mechanisms-underlying-the-benefits-of-alkali-therapy-in-chronic-kidney-disease/ (perspective).

April, 2021

Brady CT, Dugandžić A, Parker MD, Romero MF. NBCe1: An Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia. In: Hamilton K.L., Devor D.C. (eds) Studies of Epithelial Transporters and Ion Channels. Physiology in Health and Disease. Springer, Cham. (2020) https://doi.org/10.1007/978-3-030-55454-5_4 (book chapter).

March, 2021

Brady C, Chemaly ER, Lohr JW, Parker MD. Veverimer: an advance in base therapy for metabolic acidosis. Annals of Translational Medicine. 2020;0(0). doi:10.21037/atm-20-2827 (editorial).

May, 2020

Brady C, Denora M, Shannon I, Clark KJ, Rich A. Intestinal Transit Time and Cortisol-Mediated Stress in Zebrafish. Zebrafish. 2017;14(5):404-410. doi:10.1089/zeb.2017.1440

October, 2017

Brady CT, Giesen CD, Voskoboev N, Chirackal RS, Gavrilov DK, Flanagan RM, Lieske JC. Cyanide-Nitroprusside Colorimetric Assay: A Rapid Colorimetric Screen for Urinary Cystine. The Journal of Applied Laboratory Medicine: An AACC

Publication. 2017;2(1):55-64. doi:10.1373/jalm.2016.022582.

July, 2017

Brady C, Parker M. Back to Basics: The importance of Bicarbonate Transport.

University at Buffalo JSMBS Department of Physiology Seminar series – Oral Presentation.

October 7, 2021

Brady C, Marshall A, Parker M. The importance of renal NBCe1-B during metabolic acidosis. Experimental Biology – APS renal section, Posters and Professor’s – Oral presentation. *Excellence in Renal Research - Predoctoral Award, 2^nd place.

April 26, 2021

Brady C, Pearson M, Marshall A, Parker M. Cellular remodeling of cardiomyocytes: an unappreciated phenotype of congenital pRTA? American Society of Nephrology - Kidney Week Conference – Poster presentation. Walter

E. Washington Convention Center; Washington, D.C. (Kidney STARS participant).

November 9, 2019

Brady C, Pearson M, Marshall A, Parker M. Consequences of Altered Bicarbonate Transport. Tri-Institutional Research Day – Poster presentation. UB Jacobs School of Medicine and Biomedical Sciences; Buffalo, NY.

October 12, 2019

Brady C, Alsufayan T, Marshall A, Parker M. Loss of Electrogenic Sodium-Bicarbonate Cotransporter Produces Signs of Cardiac Hypertrophy in Mice. Tri-Institutional Research Day – Poster presentation. Upstate Medical University; Syracuse, NY.

October 13, 2018

Brady C, Rich A. Expression of Anoctamin 1 in Adult Zebrafish. National Conference for Undergraduate Research – Poster presentation. University of Memphis; Memphis, TN.

April 8, 2017

Brady C, Giesen C, Voskoboev N, Chirackal R, Gavrilov D, Flanagan R, Lieske JC. Cyanide-Nitroprusside Colorimetric Assay: A Rapid Screen for Urinary Cystine. American Society of Nephrology-Kidney Week Conference – Poster presentation. McCormick Place; Chicago, IL

November 18, 2016

Brady C, Mahoney A, Smith T, Rich A. Calcium Activity in the Zebrafish Neuromast. Rochester Academy of Science – Poster presentation. Roberts Wesleyan College; Rochester, NY.

November 12, 2016

Brady C, Giesen C, Voskoboev N, Chirackal R, Gavrilov D, Flanagan R, Lieske JC. Cyanide-Nitroprusside Colorimetric Assay: A Rapid Screen for Urinary Cystine. Mayo Clinic nuSURF Symposium – Oral presentation. The Mayo Clinic; Rochester, MN. *1^st place presentation award competition

August 2, 2016

Brady C, Rich A. Expression of Anoctamin-1 in Adult Zebrafish.

Scholar’s Day – Poster presentation. The College at Brockport, State University of New York; Brockport, NY.

April 6, 2016

Brady C, Voskoboev N, Lieske JC. A Rapid Colorimetric Assay to Accurately Measure Urinary Cystine. Kidney, Urologic, and Hematologic Diseases Research Conference – Poster presentation. Emory University School of Medicine; Atlanta, GA.

July 30, 2015

Brady C. Spatial Expression Patterns of Anoctamin-1 in Adult Zebrafish. SUNY

Undergraduate Research Day – Oral presentation. The College at Brockport, State University of New York; Brockport, NY.

April 10, 2015

Brady C, Rich A. Stress does not Interfere with Gastrointestinal Motility in the Zebrafish. Rochester Academy of Science – Oral presentation. The College at Brockport, State University of New York; Brockport, NY.

November 15, 2014

Brady C, Shannon I, Rich A. The Physiological Role of Anoctamin-1.

Scholar’s Day – Oral presentation. The College at Brockport, State University of New York; Brockport, NY.

April 10, 2014

MD/PhD steering committee – student ambassador

JSMBS, Buffalo, NY

Represented MD/PhD student body in a student/faculty committee, with input on curriculum design, academic affairs, funding, and social programs regarding the UB MD/PhD program. Worked with faculty to design and implement a longitudinal clinical preceptorship for MD/PhD students in their graduate years.

2021-2022

MD/PhD Graduate Student Association Club Officer

JSMBS, Buffalo, NY

Involves funding, organizing, and implementing academic and social events to bring together UB MD/PhD students.

VP, 2020-2021

Treasurer, 2019-2020

Lighthouse Free Medical Clinic – Volunteer

JSMBS, Buffalo, NY

Provided free primary care services to city of Buffalo residents. Involves working in groups of two under supervision of an on-site attending physician.

March 2018 – Present

(~25 hours)

First Year Medical Student Tutor

JSMBS, Buffalo, NY

As a second-year medical student, I tutored a small group of first year students through biochemistry, immunology, hematology, and gastroenterology modules.

October 2018 – April 2019

(~30 hours)

Floating Doctors – Volunteer

Bocas Del Toro, Panama

Week long medical mission trip providing free medical care to rural regions of Panama. Worked along side physicians, residents, nurses, and other medical students.

April 8^th – 14^th, 2018

Emergency Medical Technician - Basic

Perinton Volunteer Ambulance Corps, Perinton, NY

Provided emergency medical care to the Perinton community. Gained experience in patient care and rapid decision-making in high acuity situations. Interacted directly with health care professionals such as paramedics, nurses, and physicians.

June, 2014 – May, 2017

(~500 hours)

Teaching Assistant - Organic Chemistry II

The College at Brockport, State University of New York

Assisted students in working through organic chemistry laboratory curriculum. Involved both clarifying material and helping students with general lab procedures.

January, 2016 – May, 2016

Honors Peer Mentor

The Honors College at The College at Brockport, State University of New York Provide mentorship to incoming freshmen Honors students. Led weekly meetings over the fall semesters. Helped students in classwork, class

registration, and aided in the high school to college transition.

August, 2014 – December, 2016

American Physiology Society

2021 – present

American Medical Association

2018 – present

American Physician Scientists Association

2017 – present

American Society of Nephrology

2016 – present

Alpha Chi National Honors Society

Inducted November 11, 2016

Tri-Beta National Biology Honors Society

Inducted May 11, 2016

Omicron Delta Kappa National Leadership Honors Society

Inducted May 7, 2016

SUNY GREAT award – Graduate Research Empowering and Accelerating Talent

March, 2021

Jacobs School of Medicine and Biomedical Sciences Deans Letter of Commendation (Pre-clinical M1 and M2 years)

October, 2018 & 2019

SUNY Chancellors Award

May, 2017

The College at Brockport - School of Science and Mathematics Undergraduate Award

April, 2017

The College at Brockport President’s List (4 semesters), Dean’s List with Honors (2 semesters), Dean’s List (2 semesters)

2013 - 2017

The College at Brockport - Francis Claffey Departmental Biology Award

February, 2016

Stephen Besch Scholarship

February, 2021

Brockport Honors Scholarship (full tuition award)

2013-2017

Alpha Chi, H.Y. Benedict Fellowship Award

November, 2017

Henry L. Bretton and Marian More Bretton Pre-Med Scholarship

June, 2016

Dr. and Mrs. Herbert S. (Inez W.) Bailey Pre-Med Scholarship

June, 2016

Elizabeth More Bretton Pre-Med Scholarship

May, 2014 & 2015

Brockport Physics, Mathematics, and Computer Science Scholarship recipient

September, 2015

Institute for Engaged Learning Summer Research Scholarship recipient

June, 2013