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Granger Biosketch

OMB No. 0925-0001 and 0925-0002 (Rev. 03/2020 Approved Through 02/28/2023)

BIOGRAPHICAL SKETCH

NAME: Joey P. Granger, Ph.D.

eRA COMMONS USER NAME (credential, e.g., agency login): joey_granger

POSITION TITLE: Professor of Physiology and Medicine

EDUCATION/TRAINING

Personal Statement

Joey P. Granger is the Billy S. Guyton Distinguished Professor, Professor of Physiology and Medicine, Director of the in Cardiovascular-Renal Research Center, and Dean of the School of Graduate Studies in the Health Sciences at the University of Mississippi Medical Center in Jackson, MS. He earned his doctorate from Arthur Guyton’s Physiology Department at the University of Mississippi Medical Center and where John E. Hall served as his Ph.D. mentor. He received his postdoctoral training in physiology in the laboratory of Franklyn G. Knox at the Mayo Clinic from 1983–1985. He was appointed Assistant Professor of Physiology at Mayo Medical School in 1985. In 1986, he joined the faculty of the Department of Physiology at Eastern Virginia Medical School. In 1990, he moved back to the University of Mississippi Medical Center.

Granger’s research has focused on the role of the kidneys in the pathogenesis of hypertension. His early research examined the importance of renal interstitial hydrostatic pressure in mediating renal pressure natriuresis. He also examined the importance of atrial natriuretic peptide (ANP) in long-term control of sodium balance and arterial pressure. He demonstrated that ANP had potent actions on the renin-angiotensin system and that chronic physiological elevations in plasma ANP produced long-term improvement in renal pressure natriuresis and reductions in arterial pressure. His later work investigated the role of the renal endothelin and nitric oxide systems in various models of salt-sensitive hypertension. His current research focuses on the role of endothelial and neurohormonal factors in mediating hypertension in animal models of pregnancy-induced hypertension or preeclampsia. Utilizing the RUPP (Reduced Uterine Perfusion Pressure) model of placental ischemia, which was developed by the Granger laboratory, they demonstrated that placental ischemia in the pregnant rat has many of the features of preeclampsia in women. They are currently using this model for the investigation of the mechanisms linking placental ischemia and cardiovascular dysfunction in preeclampsia and for identifying potential drug targets for the treatment of preeclampsia. His laboratory has been continuously funded by the National Heart, Lung and Blood Institute (NHLBI) since 1985. Granger also currently serves as the principal investigator of a NHLBI Institutional Training Grant entitled “Hypertension and Cardiorenal Diseases Research Training Program”. Dr. Granger has mentored many outstanding investigators at UMMC and other academic institutions (>40 trainees). Many of his trainees have obtained positions in the academic and biotechnology industry. Granger has authored or co-authored over 250 peer-reviewed publications. His researchcited more than 20,000 times and his H-index is 72. He has served on numerous scientific program committees including Council on Hypertension, American Physiological Society, InterAmerican Society of Hypertension, American Society of Hypertension, APS Pan American meetings, International Endothelin meetings, FASEB Summer Conferences on renal hemodynamics and the International Society of Hypertension in Pregnancy. He has also served a chair or co-chair of programming for FASEB Summer Conferences, International Society of Hypertension in Pregnancy and the AHA Council on Hypertension Scientific sessions.

Positions and Honors

Professional Experience:

1985-86 Asst. Professor, Dept. of Physiology and Biophysics, Mayo Med. School, Rochester, MN 1985-86 Associate Consultant, Mayo Clinic and Foundation, Rochester, MN

1986-88 Assistant Professor, Dept. of Physiology, Eastern Virginia Medical School, Norfolk, VA 1988-90 Assoc. Professor, Dept. of Physiology, Eastern Virginia Med. School, Norfolk, VA

1990-Pr. Professor, Dept. of Physiology and Biophysics, Univ. Mississippi Medical Center, Jackson, MS

2008-Pr. Dir., Center for Excellence in Cardiovascular Renal Research, Univ. of MS Med.Center

2004-Pr. Billy S. Guyton Distinguished Professor, Univ. of Mississippi Medical Center

Honors and Awards (Selected):

Granger is currently an Associate Editor for Hypertension and serves as Co-Editor with his brother, Neil Granger, on the eBook series entitled Integrative Systems Physiology. He has also served as the Editor of the Council for High Blood Pressure Newsletter and an Associate Editor for News in Physiological Sciences and American Journal of Physiology: Regulatory and Integrative Physiology. He is serving or has served as a member of Editorial Boards of American Journal of Hypertension, American Journal of Physiology: Renal Physiology, American Journal of Physiology: Regulatory and Integrative Physiology, Journal of CardioMetabolic Syndrome and the Journal of the American Society of Hypertension.

Granger served as President of the American Physiology Society in 2012 and was currently serves as Chair ofthe Council on Hypertension of the American Heart Association. He also currently serves on Leadership committees of the Inter-American Society of Hypertension. He also served on numerous scientific committees of the Council for High Blood Pressure Research, Inter-American Society of Hypertension, American Society of Hypertension, and the American Physiological Society. Within the American Physiological Society he has served as a Councilor, Chair of Committee on Committees, Long-Range Planning Committee, Career Opportunities Committee, Program Committee, President of the Gulf Coast Physiological Society, Chair of the Water and Electrolyte Homeostasis Section, Section Advisory Committee, Nominating Committee, Publication Committee, Finance Committee, Strategic Planning Committee, and as a mentor for the Frontiers in Physiology program and APS/NIDDK minority fellowship program and the APS Summer Undergraduate Research program. Granger has also served on scientific study sections for the American Heart Association, National Institutes of Health, NASA, and the Veterans Administration. He recently served as chair of the Hypertension and Microcirculation NIH study section. He also served on the National Board Medical Exam Physiology Test Development Committee.

Granger has received numerous research awards including the 2010 American Heart Association Distinguished Scientist Award, American Physiological Society 2008 E.H. Starling Distinguished Lecture Award, American Physiological Society 2008 Bodil M. Schmidt-Nielsen Distinguished Mentor and Scientist Award, Dahl Memorial Lecture of the American Heart Association, American Society of Hypertension Young Scholar Award, the International Society of Hypertension Demuth Research Award, Inter-American Society of Hypertension Young Investigator Award, the Regulatory and Integrative Physiology Young Investigator Award of the American Physiological Society Water and Electrolyte Section, the Harold Lamport Award of the Cardiovascular Section of the American Physiological Society, the Henry Pickering Bowditch Lecture of the American Physiological Society, and the Established Investigator Award of the American Heart Association.

Contribution to Science

Granger’s overall research program over the last 30 years has examined molecular mechanisms in the pathogenesis of hypertension. His early research demonstrated the importance of renal interstitial hydrostatic pressure in mediating renal pressure natriuresis and how this mechanism is deranged in various models of hypertension. He was also one of the first to demonstrate the importance of atrial natriuretic peptide (ANP) in long-term control of sodium balance and arterial pressure. He also demonstrated the intrarenal actions of synthetic ANP He also demonstrated that ANP had potent actions on the renin- angiotensin system and that chronic physiological elevations in plasma ANP produced long-term improvement in renal pressure natriuresis and reductions in arterial pressure

1. Granger, J. P., T. J. Opgenorth, J. Salazar, J. C. Romero, and J. C. Burnett, Jr. Long-term hypotensive and renal effects of chronic infusions of atrial natriuretic peptide in conscious dogs. Hypertension 8:II-112-II-116, 1986
2. Granger, J. P., J. Haas, and F. G. Knox. Effects of direct increase in renal interstitial hydrostatic pressure on sodium excretion. Am. J. Physiol. 254:F527-F532, 1988

His later work investigated the role of the renal endothelin and nitric oxide systems in various models of salt- sensitive hypertension. His laboratory demonstrated that nitric oxide plays a critical role in protecting the preglomerular vessels from ANGII and norepinephrine vasoconstriction and loss of nitric oxide leads to renal failure and hypertension. They also demonstrated that nitric oxide regulated renin release via a macula densa mediated mechanism. Finally, in a series of studies the Granger laboratory demonstrated an important effect of endothelin on renal function and blood pressure regulation in a number of models of models of hypertension.

1. Kato, T., S. Kassab, F. C. Wilkins, K. Kirchner, J. Keiser, and J. P. Granger. Endothelin antagonist improve renal function in spontaneously hypertensive rats. Hypertension 25(2):883-887, 1997
2. Granger, J. P., C. G. Schnackenberg, J. Novak, B. Tucker, T. Miller, S. Morgan, and S. E. Kassab. Role of nitric oxide in modulating the long-term renal and hypertensive action of norepinephrine. Hypertension 29(2):205-209, 1997
3. Kassab, S., J. Novak, T. Miller, K. A. Kirchner, and J. Granger. Cardiovascular and renal actions of endothelin receptor antagonism in Dahl salt-sensitive hypertension. Hypertension 30(3):682-686 1997

His current research focuses on the role of endothelial and neurohormonal factors in mediating hypertension in animal models of pregnancy-induced hypertension or preeclampsia. His laboratory over the last 5 years has published over 50 peer-reviewed manuscripts on the topic of pathophysiology of preeclampsia. Utilizing the RUPP (Reduced Uterine Perfusion Pressure) model of placental ischemia, which was developed by the Granger laboratory, they demonstrated that placental ischemia in the pregnant rat has many of the features of preeclampsia in women. They are currently using this model for the investigation of the mechanisms linking placental ischemia and cardiovascular dysfunction in preeclampsia and for identifying potential drug targets for the treatment of preeclampsia. They are also investigating molecular mechanisms whereby obesity increases the risk for developing preeclampsia. Dr. Granger was recently appointed by American College of Obstetricians and Gynecologists on Hypertension in Pregnancy Working Group, where he was responsible for outlining future directions in preeclampsia research.

1. Alexander, B. T., S. E. Kassab, M. T. Miller, S. R. Abram, J. F. Reckelhoff, A. Bennett, and J. P. Granger. Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide. Hypertension. 37: 1191-1195, 2001.
2. Alexander, T., A. N. Rinewalt, K. L. Cockrell, W. A. Bennett, and J. P. Granger. Endothelin-A receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure. Hypertension. 37:485-489, 2001
3. Murphy SR, BB LaMarca, K Cockrell, JP Granger. Soluble fms-Like Tyrosine-1 Induced Hypertension: Role of Endothelin. Hypertension 2010 Feb;55(2):394-8. NIHMS172853

Complete List of Published Work in My Bibliography
My NCBI - Bibliography: http://www.ncbi.nlm.nih.gov/pubmed/?term=granger+jp

Research Support

ACTIVE

NIH 1T32HL105324 2010-2022 Hypertension and Cardiorenal Diseases
Research Training Program PI: J.P. Granger
The major goal of this project is to train graduate students and postdocs in cardiovascular-renal research.

NIH 1P20 GM 104357 2013-2020 Cardiorenal and Metabolic Diseases
Research Center Hall (PI)
Co-Investigator: J.P. Granger
The major goal of this COBRE grant is to develop a Cardiorenal and Metabolic Resources Research Center.

R01 HL136684 2017-2021 Placental Ischemia, Hypertension and Hemodynamics
Ryan (PI)
Co-Principle Investigator: J.P. Granger
The goal of this project is to determine the role of placental factors causing cerebral vascular dysfunction in response to placental ischemia.

U54 GM115428 2016 - 2021 Mississippi Center for Clinical and Translational Research
PI: JP Granger
The goal of this project is to develop the infrastructure needed to support a sustained and growing program of clinical, translational, population, and community-engaged research into obesity and related disorders at the University of Mississippi Medical Center, Tougaloo College, and the University of Southern Mississippi.

R01HL137987 2018- 2022 Renal hemodynamics and hypertension during Pregnancy
Liu (PI)
Co-Investigator
The goal is to determine the role of macula densa in NOS in pregnancy and preeclampsia.