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Summary of Research

I investigate the neuronal control of immune responses during acute myocardial infarction. Myocardial infarction possesses a significant risk for morbidity and mortality despite a wide variety of available medication. Although myocardial infarction results in significant myocardial inflammation, no available drug targets this aspect of the pathology. Direct immunosuppressive therapies were deemed unsuccessful, thus we aim to understand, and employ in the future, mechanisms of neuronal control upon the immune system. In order to achieve this goal, we use MI surgeries to model the disease, genetic approaches to untangle the interorgan communications, different flow cytometric technics to study cellular and subcellular dynamics, and bioinformatics to identify potential molecular and cellular targets.