Jeannette Simino
Associate Professor
Department:
SPH-Dept of Data Science
Email:
jsimino@umc.edu
Work Phone:
(601) 815-8128
Education
| Washington University School of Medicine, St. Louis, Missouri, MS, Genetic Epidemiology | 2012 |
| Florida State University, Tallahassee, Florida, PhD, Statistics | 2009 |
| Florida State University, Tallahassee, Florida, MS, Statistics | 2007 |
| Case Western Reserve University, Cleveland, Ohio, MS, Biostatistics | 2001 |
| Texas A&M University School of Medicine, Regents Fellow (23 credit hours didactic and wet lab training), Molecular Pathology | 1999 |
| University of Missouri, Columbia, Missouri, BS, Mathematics | 1998 |
| University of Missouri, Columbia, Missouri, BS, Biochemistry | 1998 |
Current Positions
| Associate Professor, School of Population Health, Department of Data Science | 07/2021 - Present |
| Associate Professor, School of Graduate School in the Health Sciences | 07/2021 - Present |
| Investigator, Gertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, School of Medicine | 10/2014 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Mississippi Medical Center, School of Population Health, Department of Data Science (Grew from the Center for Biostatistics & Bioinformatics in the School of Medicine) | 04/2016 - 06/2021 |
| Assistant Professor, University of Mississippi Medical Center, School of Graduate School in the Health Sciences | 11/2015 - 06/2021 |
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Medicine, Center for Biostatistics & Bioinformatics | 07/2015 - 06/2021 |
| Biostatistician III, University of Mississippi Medical Center, School of Medicine | 10/2014 - 07/2015 |
| Research Instructor, Washington University, School of Medicine, Department of Biostatistics | 07/2012 - 06/2014 |
| Post-doctoral Fellow in Cardiovascular Genetic Epidemiology, Washington University, School of Medicine, Department of Biostatistics | 07/2009 - 06/2012 |
Sponsored Program Funding
| Extramural, Master of Science in Biostatistics & Data Science Scholarship, Robert M Hearin Foundation | 08/2022 - 05/2026 |
| Extramural, Master of Science in Biostatistics & Data Science Scholarship, Robert M Hearin Foundation, Role: Principal Investigator | 07/2019 - 05/2022 |
| Extramural, 1RF1AG059421: Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC); (PI: Sudha Sehadri), Role: Subaward PI, NIA | 01/2019 - 03/2023 |
| Extramural, R01 HL142003 Subaward 0013477D: Trans-omics analysis to unravel molecular underpinnings of heart, lung, and blood disease risk factors (PI: Bing Yu); Role: Subaward PI., NHLBI | 05/2018 - 04/2021 |
| Intramural, Neurogenetics Core Member, Memory Impairment and Neurodegenerative Dementia (MIND) Center | 10/2014 - Present |
| Extramural, R01 HL111249: Rare Variants for Hypertension in Taiwan Chinese (PI:DC Rao), Role: Genetic Epidemiologist, NHLBI | 07/2012 - 06/2014 |
| Extramural, R01 HL107552: Gene-Environment Interactions in the Longitudinal Framingham Heart Study (PI: DC Rao), Role: Genetic Epidemiologist, NHLBI | 08/2011 - 03/2014 |
| Extramural, R01 HL086694:Genome-Wide Association Analysis in Essential Hypertension (FEHGAS2; PI: Aravinda Chakravarti), Role: Genetic Epidemiologist, NHLBI | 07/2010 - 05/2014 |
| Extramural, T32 HL091823: Post-doctoral Research Training in Genetic Epidemiology (PI: DC Rao), Role: Post-doctoral fellow, NHLBI | 07/2009 - 06/2012 |
| Extramural, Pre-doctoral Fellowship- Florida/Puerto Rico Affiliate, Role: Pre-doctoral fellow, American Heart Association | 07/2003 - 06/2005 |
| Extramural, Undergraduate Summer Research Scholar, Role: Undergraduate Summer Research Scholar, Howard Hughes | 05/1997 - 08/1997 |
Publications
Collaborator, part of banner authorship | |
| Kessler MD, Loesch DP, Perry JA, Heard-Costa NL, Taliun D, Cade BE, Wang H, Daya M, Ziniti J, Datta S, Celedón JC, Soto-Quiros ME, Avila L, Weiss ST, Barnes K, Redline SS, Vasan RS, Johnson AD, Mathias RA, Hernandez R, Wilson JG, Nickerson DA, Abecasis G, Browning SR, Zöllner S, O'Connell JR, Mitchell BD, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium**, TOPMed Population Genetics Working Group., O'Connor TD. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population. Proceedings of the National Academy of Sciences of the United States of America, 2020 Feb 4;117(5):2560-2569.** Simino is part of the TOPMed Neurocognitive Group and listed as a collaborator in PubMed. | 2020 |
| Sarnowski C, Satizabal CL, DeCarli C, Pitsillides AN, Cupples LA, Vasan RS, Wilson JG, Bis JC, Fornage M, Beiser AS, DeStefano AL, Dupuis J, Seshadri S; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Neurocognitive Working Group**. Whole genome sequence analyses of brain imaging measures in the Framingham Study Neurology. 2018 Jan 16;90(3):e188-e196. ** Simino is part of the TOPMed Neurocognitive Group and listed as a collaborator in PubMed. | 2018 |
Banner Authorship | |
| McGee, DL, The Diverse Populations Collaboration*. Body mass index and mortality: a meta-analysis based on person-level data from twenty-six observational studies. Annals of Epidemiology. 2005 February; 15(2): 87-97. * Simino is listed as part of the Diverse Populations Collaboration. | 2005 |
| The Diverse Populations Collaboration*. Smoking, body weight, and CHD mortality in diverse populations Preventive Medicine. 2004 June; 38(6): 834-840. * Simino is listed as part of the Diverse Populations Collaboration. | 2004 |
Undergoing co-author reviews | |
| George KM, Lutsey PL, Johnson EL, Pankow JS, Tang W, Fornage M, Simino J, Vossel KA.Association of Genetic Risk Scores for Alzheimer’s Disease With Incidence of Late-Onset Epilepsy; the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). (submitted) Association of Genetic Risk Scores for Alzheimer’s Disease With Incidence of Late-Onset Epilepsy; the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). | |
| Mei H*, Simino J*, et al. * Authors contributed equally Pathway Analyses of Genome-wide Associations Implicate Immunity in Verbal Declarative Memory Performance; the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. | |
Journal Article | |
| Frenzel S, Bis JC, Gudmundsson EF, O’Donnell A, Simino J, Yaqub A, Bartz TM, Brusselle GGO, Bülow R, DeCarli CS, Ewert R, Gharib SA, Ghosh S, Gireud-Goss M, Gottesman RF, Ikram MA, Knopman DS, Launer LJ, London SJ, Longstreth WT, Lopez O, Melo van Lent D, O’Connor G, Satizabal CL, Shrestha S, Sigurdsson S, Stubbe B, Talluri R, Vasan RS, Vernooij MW, Völzke H, Wiggins KL, Yu B, Beiser AS, Gudnason V, Mosley TH, Psaty BM, Wolters FJ, Grabe HJ, Seshadri S Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis; Cross-Cohort Collaboration Consortium (accepted to the Journal of Alzheimer’s Disease) | 2022 |
| Tin A, Sullivan KJ, Walker KA, Bressler J, Talluri R, Yu B, Simino J, Gudmundsdottir V, Emilsson V, Jennings LL, Launer L, Mei H, Boerwinkle E, Windham BG, Gottesman R, Gudnason V, Coresh J, Fornage M, Mosley TH Proteomic analysis identifies circulating proteins associated with plasma amyloid βeta and incident dementia (accepted to Biological Psychiatry: Global Open Science) | 2022 |
| Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, van der Lee SJ, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Anne C Böhmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Hartmann AM, Hatzimanolis A, Heiss G, Holliday EG, Joshi PK, Kähönen M, Kardia SLR, Karlsson I, Kleineidam L, Knopman DS, Kochan NA, Konte B, Kwok JB, Le Hellard S, Lee T, Lehtimäki T, Li SC, Liu T, Koini M, London E, Longstreth WT, Lopez OL, Loukola A, Luck T, Lundervold AJ, Lundquist A, Lyytikäinen LP, Martin NG, Montgomery GW, Murray AD, Need AC, Noordam R, Nyberg L, Ollier W, Papenberg G, Pattie A, Polasek O, Poldrack RA, Psaty BM, Reppermund S, Riedel-Heller SG, Rose RJ, Rotter JI, Roussos P, Rovio SP, Saba Y, Sabb FW, Sachdev PS, Satizabal C, Schmid M, Scott RJ, Scult MA, Simino J, Slagboom PE, Smyrnis N, Soumaré A, Stefanis NC, Stott DJ, Straub RE, Sundet K, Taylor AM, Taylor KD, Tzoulaki I, Tzourio C, Uitterlinden A, Vitart V, Voineskos AN, Kaprio J , Wagner M, Wagner H, Weinhold L, Wen KH, Widen E, Yang Q, Zhao W, Adams HHH, Arking DE, Bilder RM, Bitsios P, Boerwinkle E, Chiba-Falek O, Corvin A, De Jager PL, Debette S, Donohoe G, Elliott P, Fitzpatrick AL, Gill M, Glahn DC, Hägg S, Hansell NK, Hariri AR, Ikram MK, Jukema JW, Vuoksimaa E, Keller MC, Kremen WS, Launer L, Lindenberger U, Palotie A, Pedersen NL, Pendleton N, Porteous DJ, Räikkönen K, Raitakari OT, Ramirez A, Reinvang I, Rudan I, Rujescu D, Schmidt R, Schmidt H, Schofield PW, Schofield PR, Starr JM, Steen VM, Trollor JN, Turner ST, Van Duijn CM, Villringer A, Weinberger DR, Weir DR, Wilson JF, Malhotra A, McIntosh AM, Gale CR, Seshadri S, Mosley TH, Bressler J, Lencz T, Deary IJ. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function Nat Commun. 2018 May 29;9(1):2098. | 2018 |
| West N, Tingle J, Simino J, Selvin E, Bressler J, Mosley TH. The PPAR-γ Pro12Ala Polymorphism and 20-Year Cognitive Decline: Race and Sex Heterogeneity. Alzheimer Dis Assoc Disord. 2018 Apr-Jun;32(2):131-136 | 2018 |
| Marioni R, McRae A, Colicino E, Hannon E, Li S, Prada D, Smith J, Trevisi L, Tsai PC, Vojinovic D, Bressler J, Simino J, Liu C, Mendelson M, Satizabal C, Yang Q, Jhun MA, Kardia S, Zhao W, Bandinelli S, Ferrucci L, Hernandez D, Singleton A, Harris S, Starr J, Kiel D, McLean R, Just A, Schwartz J, Spiro A, Vokonas P, Amin N, Ikram MA, Uitterlinden A, van Meurs J, Spector T, Steves C, Baccarelli A, Bell J, van Duijn C, Fornage M, Hsu YH, Mill J, Mosley T, Seshadri S, Deary I, and Levy D Meta-analysis of epigenome-wide association studies of cognitive abilities Mol Psychiatry. 2018. Nov; 23(11)2133-2144. | 2018 |
| Graff-Radford J*, Simino J*, Mosley TH, Griswold ME, Windham BG, Gottesman RF, Sharrett AR, Albert M, Jack C, Kantarci K, Vemuri P Neuroimaging correlates of cerebral microbleeds: The ARIC Study (Atherosclerosis Risk in Communities). Stroke. 2017 Nov;48(11):2964-2972.* authors contributed equally | 2017 |
| Simino J, Wang Z, Bressler J, Chouraki V, Yang Q, Younkin SG, Seshadri S, Fornage M, Boerwinkle E, Mosley TH Whole exome sequence-based association analyses of plasma amyloid-beta in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study. PLoS One 2017. 12(7):e0180046. | 2017 |
| Mei H, Li L, Jiang F, Simino J, Griswold M, Mosley TH, and Liu S. snpGeneSets: An R Package for Genome-Wide Study Annotation G3 (Bethesda). 2016 Dec 7;6(12):4087-4095. | 2016 |
| Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Scharnagl H, Shi J, Smith AV, Southam L, Stančáková A, Steinthorsdottir V, Strawbridge RJ, Sung YJ, Tachmazidou I, Tanaka T, Thorleifsson G, Trompet S, Pervjakova N, Tyrer JP, Vandenput L, van der Laan SW, van der Velde N, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Vlachopoulou E, Waite LL, Wang SR, Wang Z, Wild SH, Willenborg C, Wilson JF, Wong A, Yang J, Yengo L, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Andersson EA, Bakker SJ, Baldassarre D, Banasik K, Barcella M, Barlassina C, Bellis C, Benaglio P, Blangero J, Blüher M, Bonnet F, Bonnycastle LL, Boyd HA, Bruinenberg M, Buchman AS, Campbell H, Chen YD, Chines PS, Claudi-Boehm S, Cole J, Collins FS, de Geus EJ, de Groot LC, Dimitriou M, Duan J, Enroth S, Eury E, Farmaki AE, Forouhi NG, Friedrich N, Gejman PV, Gigante B, Glorioso N, Go AS, Gottesman O, Gräßler J, Grallert H, Grarup N, Gu YM, Broer L, Ham AC, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Heath AC, Henders AK, Hernandez D, Hillege H, Holmen O, Hovingh KG, Hui J, Husemoen LL, Hutri-Kähönen N, Hysi PG, Illig T, De Jager PL, Jalilzadeh S, Jørgensen T, Jukema JW, Juonala M, Kanoni S, Karaleftheri M, Khaw KT, Kinnunen L, Kittner SJ, Koenig W, Kolcic I, Kovacs P, Krarup NT, Kratzer W, Krüger J, Kuh D, Kumari M, Kyriakou T, Langenberg C, Lannfelt L, Lanzani C, Lotay V, Launer LJ, Leander K, Lindström J, Linneberg A, Liu YP, Lobbens S, Luben R, Lyssenko V, Männistö S, Magnusson PK, McArdle WL, Menni C, Merger S, Milani L, Montgomery GW, Morris AP, Narisu N, Nelis M, Ong KK, Palotie A, Pérusse L, Pichler I, Pilia MG, Pouta A, Rheinberger M, Ribel-Madsen R, Richards M, Rice KM, Rice TK, Rivolta C, Salomaa V, Sanders AR, Sarzynski MA, Scholtens S, Scott RA, Scott WR, Sebert S, Sengupta S, Sennblad B, Seufferlein T, Silveira A, Slagboom PE, Smit JH, Sparsø TH, Stirrups K, Stolk RP, Stringham HM, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Thorand B, Tönjes A, Tremblay A, Tsafantakis E, van der Most PJ, Völker U, Vohl MC, Vonk JM, Waldenberger M, Walker RW, Wennauer R, Widén E, Willemsen G, Wilsgaard T, Wright AF, Zillikens MC, van Dijk SC, van Schoor NM, Asselbergs FW, de Bakker PI, Beckmann JS, Beilby J, Bennett DA, Bergman RN, Bergmann S, Böger CA, Boehm BO, Boerwinkle E, Boomsma DI, Bornstein SR, Bottinger EP, Bouchard C, Chambers JC, Chanock SJ, Chasman DI, Cucca F, Cusi D, Dedoussis G, Erdmann J, Eriksson JG, Evans DA, de Faire U, Farrall M, Ferrucci L, Ford I, Franke L, Franks PW, Froguel P, Gansevoort RT, Gieger C, Grönberg H, Gudnason V, Gyllensten U, Hall P, Hamsten A, van der Harst P, Hayward C, Heliövaara M, Hengstenberg C, Hicks AA, Hingorani A, Hofman A, Hu F, Huikuri HV, Hveem K, James AL, Jordan JM, Jula A, Kähönen M, Kajantie E, Kathiresan S, Kiemeney LA, Kivimaki M, Knekt PB, Koistinen HA, Kooner JS, Koskinen S, Kuusisto J, Maerz W, Martin NG, Laakso M, Lakka TA, Lehtimäki T, Lettre G, Levinson DF, Lind L, Lokki ML, Mäntyselkä P, Melbye M, Metspalu A, Mitchell BD, Moll FL, Murray JC, Musk AW, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Oostra BA, Palmer LJ, Pankow JS, Pasterkamp G, Pedersen NL, Pedersen O, Penninx BW, Perola M, Peters A, Polašek O, Pramstaller PP, Psaty BM, Qi L, Quertermous T, Raitakari OT, Rankinen T, Rauramaa R, Ridker PM, Rioux JD, Rivadeneira F, Rotter JI, Rudan I, den Ruijter HM, Saltevo J, Sattar N, Schunkert H, Schwarz PE, Shuldiner AR, Sinisalo J, Snieder H, Sørensen TI, Spector TD, Staessen JA, Stefania B, Thorsteinsdottir U, Stumvoll M, Tardif JC, Tremoli E, Tuomilehto J, Uitterlinden AG, Uusitupa M, Verbeek AL, Vermeulen SH, Viikari JS, Vitart V, Völzke H, Vollenweider P, Waeber G, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Zeggini E; CHARGE Consortium; DIAGRAM Consortium; GLGC Consortium; Global-BPGen Consortium; ICBP Consortium; MAGIC Consortium, Chakravarti A, Clegg DJ, Cupples LA, Gordon-Larsen P, Jaquish CE, Rao DC, Abecasis GR, Assimes TL, Barroso I, Berndt SI, Boehnke M, Deloukas P, Fox CS, Groop LC, Hunter DJ, Ingelsson E, Kaplan RC, McCarthy MI, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Hirschhorn JN, Lindgren CM, Heid IM, North KE, Borecki IB, Kutalik Z, Loos RJ. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet. 2015 Oct 1;11(10):e1005378. doi: 10.1371/journal.pgen.1005378. eCollection 2015 Oct. | 2015 |
| Li C, Chen W, Jiang F, Simino J, Srinivasan SR, Berenson GS, Mei H. Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study. Gene. 2015 May 15;562(2):226-31. | 2015 |
| Sung YJ, de Las Fuentes L, Schwander KL, Simino J, Rao DC. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. Am J Hypertens. 2015 Mar;28(3):343-54. | 2015 |
| Simino J*, Shi G*, Bis JC*, Chasman DI*, Ehret GB*, Gu X*, Guo X*, Hwang SJ*, Sijbrands E*, Smith AV*, Verwoert GC*, Bragg-Gresham JL, Cadby G, Chen P, Cheng CY, Corre T, de Boer RA, Goel A, Johnson T, Khor CC; LifeLines Cohort Study, Lluís-Ganella C, Luan J, Lyytikäinen LP, Nolte IM, Sim X, Sõber S, van der Most PJ, Verweij N, Zhao JH, Amin N, Boerwinkle E, Bouchard C, Dehghan A, Eiriksdottir G, Elosua R, Franco OH, Gieger C, Harris TB, Hercberg S, Hofman A, James AL, Johnson AD, Kähönen M, Khaw KT, Kutalik Z, Larson MG, Launer LJ, Li G, Liu J, Liu K, Morrison AC, Navis G, Ong RT, Papanicolau GJ, Penninx BW, Psaty BM, Raffel LJ, Raitakari OT, Rice K, Rivadeneira F, Rose LM, Sanna S, Scott RA, Siscovick DS, Stolk RP, Uitterlinden AG, Vaidya D, van der Klauw MM, Vasan RS, Vithana EN, Völker U, Völzke H, Watkins H, Young TL, Aung T, Bochud M, Farrall M, Hartman CA, Laan M, Lakatta EG, Lehtimäki T, Loos RJ, Lucas G, Meneton P, Palmer LJ, Rettig R, Snieder H, Tai ES, Teo YY, van der Harst P, Wareham NJ, Wijmenga C, Wong TY, Fornage M, Gudnason V, Levy D, Palmas W, Ridker PM, Rotter JI, van Duijn CM, Witteman JC, Chakravarti A, Rao DC. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. Am J Hum Genet. 2014 Jul 3;95(1):24-38. * Authors contributed equally | 2014 |
| Simino J*, Kume R*, Kraja AT, Turner ST, Hanis CL, Sheu WH, Chen YD, Jaquish CE, Cooper RS, Chakravarti A, Quertermous T, Boerwinkle E, Hunt SC, Rao DC. Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program. Atherosclerosis. 2014 Jul;235(1):84-93.* Authors contributed equally | 2014 |
| Simino J, Shi G, Weder A, Boerwinkle E, Hunt SC, Rao DC. Body mass index modulates blood pressure heritability: the Family Blood Pressure Program. Am J Hypertens. 2014 Apr;27(4):610-9. | 2014 |
| Basson J, Sung YJ, Schwander K, Kume R, Simino J, de las Fuentes L, Rao D. Gene-education interactions identify novel blood pressure loci in the Framingham Heart Study. Am J Hypertens. 2014 Mar;27(3):431-44. | 2014 |
| Sung YJ*, Simino J*, Kume R, Basson J, Schwander K, Rao DC. Comparison of two methods for analysis of gene-environment interactions in longitudinal family data: the Framingham heart study. Front Genet. 2014 Jan 30;5:9. doi: 10.3389/fgene.2014.00009. eCollection 2014.* Authors contributed equally | 2014 |
| Simino J, Sung YJ, Kume R, Schwander K, Rao DC. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. Front Genet. 2013 Dec 12;4:277. | 2013 |
| Simino J, Hollander M, McGee D. Calibration of proportional hazards and accelerated failure time models Comm Statist Simulation Comput 2012 ; 41(6):922-941 | 2012 |
| Shi G, Simino J, Rao DC. Enriching rare variants using family-specific linkage information. BMC Proc. 2011 Nov 29;5 Suppl 9:S82. | 2011 |
| Simino J, Shi G, Arnett D, Broeckel U, Hunt SC, Rao DC. Variants on chromosome 6p22.3 associated with blood pressure in the HyperGEN study: follow-up of FBPP quantitative trait loci. Am J Hypertens. 2011 Nov;24(11):1227-33. | 2011 |
| Simino J, Shi G, Kume R, Schwander K, Province MA, Gu CC, Kardia S, Chakravarti A, Ehret G, Olshen RA, Turner ST, Ho LT, Zhu X, Jaquish C, Paltoo D, Cooper RS, Weder A, Curb JD, Boerwinkle E, Hunt SC, Rao DC. Five blood pressure loci identified by an updated genome-wide linkage scan: meta-analysis of the Family Blood Pressure Program. Am J Hypertens. 2011 Mar;24(3):347-54. | 2011 |
Review Article | |
| Simino J, Rao DC, Freedman BI. Novel findings and future directions on the genetics of hypertension. Curr Opin Nephrol Hypertens. 2012 Sep;21(5):500-7. | 2012 |
| Basson J, Simino J, Rao DC. Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics. Curr Hypertens Rep. 2012 Feb;14(1):46-61 | 2012 |
Electronic Publications | |
| Simino J Xanax on Standby: The Semester an Anxiety-Prone Genetic Epidemiologist Taught Statistical Inference. On STATtrak September 28,2018. http://stattrak.amstat.org/2018/09/28/xanaxonstandby/ | 2018 |
Presentations
| State/Local Invited Seminars/Lectures, Simino J (oral presentation by J. Simino ). Sex Differences in Alzheimer’s Disease. MIND Center Neuroepidemiology Core Meeting, University of Mississippi Medical Center, June 24, 2022., MIND Center Neuroepidemiology Core, Jackson, MS | 06/2022 |
| Platform Presentations, Whalen Q**, Simino J (oral presentation by J. Simino ). Inflammation and dementia-free survival to age 80. Cross- Cohort Collaboration (CCC) Neurocognition Meeting, April 27, 2022 (face-to-face participants in Philadelphia, presented virtual though Zoom).** Q. Whalen is a graduate student in our Biostatistics & Data Science Ph.D. program | 04/2022 |
| Invited Symposia, Nicholas J, Alkis T, Bis JC, Brody J, Gao Y, Guo X, Larson M, Ramachandran V,Rong J, Rotter J, Simino J, Smith NL, Wilson J, Yao J, Morrison A, Yu B, Raffield L on behalf of the CHARGE Hemostasis Working Group. Fibrinogen Associated Plasma Metabolites and Implications for Cardiovascular Disease Risk., CHARGE Meeting, Philadelphia | 04/2022 |
| Poster Presentation, Gao Y** (eposter presented by Y Gao), Simino JM, Hsu CH, Correa A, Min, N. Obesity and Incident Cardiovascular Disease (CVD): The Jackson Heart Study. American Heart Association's Epidemiology and Prevention/Lifestyle and Cardiometabolic Health 2022 Scientific Session. Virtual. ** Y. Gao is a graduate student in our Biostatistics & Data Science Ph.D., American Heart Association's Epidemiology and Prevention/Lifestyle and Cardiometabolic Health 2022 Scientific Session, Virtual | 03/2022 |
| Platform Presentations, Whalen Q (Research Mentor: Simino J). Inflammation and dementia-free survival in the oldest old., University of Mississippi Medical Center | 12/2021 |
| Poster Presentation, Zhu X (poster presented by X Zhu), Shafi T, Norris KC, Simino J, Griswold ME, Lirette S. Three new race-free, community-based equations to estimate GFR: the machine learning estimation of renal function (MLERF) equations. American Society of Nephrology Kidney Week 2021, November 4, 2021. | 11/2021 |
| Platform Presentations, Mahmud S (oral presentation by S. Mahmud), Mei H, Tin A, Bressler J, Pruett WA, Fornage M, Huang J, Boerwinkle E, Mosley T, and Simino J. Whole Exome Sequence Study of Mild Cognitive Impairment in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study. Alzheimer’s Association International Conference Neuroscience Next, October 12, 2021. | 10/2021 |
| State/Local Invited Seminars/Lectures, The Genetics of Alzheimer's Disease, MIND Center Genomics Core Monthly Meeting, University of Mississippi Medical Center | 06/2021 |
| State/Local Invited Seminars/Lectures, A genome-wide association analysis of Mild cognitive impairment in African and European Americans; the Atherosclerosis Risk in Communities Neurocognitive Study, MIND Center Genomics Core, Virtual | 12/2020 |
| State/Local Invited Seminars/Lectures, Plasma Amyloid-Beta: Data Description and Issues, MIND Center Genomics Core, Virtual | 09/2020 |
| Poster Presentation, Yu B, Alkis T, Ma Y, Moon JY, Bartz T, Rong J, Simino J, Larson MG, Brody J, Fornage M, Kaplan RC, Manichaikul A, London SJ, Trans-Omics for Precision Medicine (TOPMed) Program. Metabolomic Associations with Pulmonary Function: Findings from the TOPMed Program, American Thoracic Society International Conference, Presented Virtually. | 08/2020 |
| National and International Invited Seminars/Lectures, Mei H, Simino J, Mosley T. Pathway Analyses of Genome-wide Associations Implicate Immunity in Verbal Declarative Memory Performance, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Cognitive Working Group Face-to-Face Meeting, Houston, TX | 01/2020 |
| Platform Presentations, Yu B, Ma Y, Moon JY, Bartz T, Jian R, Gao Y, Simino J, Larson M, Brody J, Kaplan R, Manichaikul A, London S (on behalf of the TOPMed Metabolomics and Lung Working Group). Metabolomics of Lung Function, TOPMed F2F Meeting, Tysons, VA | 04/2019 |
| State/Local Invited Seminars/Lectures, Am I Next? Genetic Considerations of Alzheimer's, 19th Annual Conference on Alzheimer's Disease and Other Dementias, Tupelo, MS | 08/2018 |
| State/Local Invited Seminars/Lectures, Our Frankenstats Crew: What the Department of Data Science Can Do For You, UMMC Cancer Institute Scientific Leadership Retreat: The Power of Serendipity. How Cross-Disciplinary Interactions Advance the Science of Cancer, University of Mississippi Medical Center | 06/2018 |
| Wang S, Yu H, Wenshan L, Li L, Mims PN, Maeda KJ, Wang Y, Rajkowska GK, Williams JM, Paul I, Simino J, Auchus AP, Mosley TH, Jacob H, Roman RJ, Fan F. Role of autoregulation of cerebral blood flow in diabetes-related Alzheimer-Like Cognitive Deficits., Experimental Biology, Chicago, IL | 04/2017 |
| Platform Presentations, Graff-Radford J, Simino J, Mosley TH, Griswold ME, Windham BG, Gottesman RF, Sharrett AR, Albert M, Jack C, Kantarci K, Vemuri P. Prevalence and distinct imaging correlates of deep versus lobar cerebral microbleeds: The Atherosclerosis Risk in Communities (ARIC) Study, International Stoke Conference, Houston, TX | 02/2017 |
| National and International Invited Seminars/Lectures, Simino J, Wang Z, Bressler J, Chouraki V, Yang Q, Younkin SG, Seshadri S, Fornage M, Boerwinkle E, Mosley TH. Whole exome sequence analysis of plasma amyloid-beta in African and European Americans, National Institutes of Health, ARIC Observational Study Monitoring Board, Rockville, MD | 11/2016 |
| State/Local Invited Seminars/Lectures, Simino J, Wang Z, Bressler J, Chouraki V, Yang Q, Younkin SG, Seshadri S, Fornage M, Boerwinkle E, Mosley TH. Whole Exome Sequence Analysis of Plasma Amyloid-beta in African and European Americans; the ARIC Neurocognitive Study, MIND Center Meeting, University of Mississippi Medical Center, Jackson, MS | 04/2016 |
| Poster Presentation, F Fan, J Simino, AP Auchus, DS Knopman, E Boerwinkle, M Fornage, TH Mosley, and RJ Roman. Functional Variants in CYP4A11 and CYP4F2 are Associated with Cognitive Impairment and Dementia Endophenotypes in the Elderly, International Winter Eicosanoid Conference, Baltimore, MD | 03/2016 |
| Poster Presentation, F Fan, J Simino, AP Auchus, DS Knopman, E Boerwinkle, M Fornage, TH Mosley, RJ Roman. Functional Variants In CYP4A11 AND CYP4F2 Are Associated With Cognitive Impairment and Related Dementia Endophenotypes In The Elderly, Annual Neuroscience Research Day, Jackson, MS | 03/2016 |
| Regional Invited Seminars/Lectures, Simino J (webinar). A Large-Scale Investigation of Gene-Age Interactions in Blood Pressure Regulation, Center of Biostatistics and Bioinformatics at the University of Mississippi Medical Center., Jackson, MS | 07/2014 |
| Poster Presentation, Simino J. Genome-wide association analysis of blood pressure incorporating gene-age interactions in the CHARGE, GBPgen, and ICBP Consortia, American Society of Human Genetics, San Francisco, CA | 11/2012 |
| Poster Presentation, Simino J. Five blood pressure loci identified by an updated genome-wide linkage scan: Meta analysis of the Family blood Pressure Program, American Heart Association Scientific Sessions, Chicago, IL | 11/2010 |
| Platform Presentations, Simino J, Hollander M., McGee D. (presented by Dr. Myles Hollander). Calibration of proportional hazards models, 6th St. Petersburg Workshop on Simulation, St. Petersburg, Russia | 07/2009 |
| National and International Invited Seminars/Lectures, Nicholas J, Alkis T, Bis JC, Brody J, Gao Y, Guo X, Larson M, Ramachandran V,Rong J, Rotter J, Simino J, Smith NL, Wilson J, Yao J, Morrison A, Yu B, Raffield L on behalf of the CHARGE Hemostasis Working Group. Fibrinogen Associated Plasma Metabolites and Implications for Cardiovascular Disease Risk. CHARGE Meeting April 2022 (submitted). |
Honors, Awards, and Recognition
| Pillars Beacon Award, Office of Diversity and Inclusion, University of Mississippi Medical Center | 2022 |
| TEACH (Toward Educational Advancement in Care and Health) Prize Nominee, Regions Bank | 2020 |
| Nelson Order Inductee, UMMC | 2020 |
| Graduation Faculty Marshal, John D. Bower School of Population Health | 2019 |
| Co-winner of the Best First Year Graduate Student Award in Applied Statistics, Department of Statistics, Florida State University | 2002 |
| Honors Scholar, University of Missouri | 1998 |
| Golden Key National Honor Society, University of Missouri | 1997 |
Professional Membership and Service
| Cross Cohort Collaboration (led by Sudha Seshadri at University of Texas Health Science Center at San Antonio), Member | 2019 - Present |
| Trans-Omics for Precision Medicine (TOPMed) Metabolomics Working Group, Member | 2019 - Present |
| Trans-Omics for Precision Medicine (TOPMed) Neurocognitive Working Group, Member | 2017 - Present |
| European Society of Human Genetics, Member | 2017 - Present |
| Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), Member | 2016 - Present |
| Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Cognitive Working Group (led by Jan Bressler at University of Texas Health Science Center in Houston), Officer, Secretary | 2015 - 2019 |
| Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Cognitive Working Group (led by Jan Bressler at University of Texas Health Science Center in Houston), Member | 2015 - Present |
| American Society of Human Genetics, Member | 2012 - Present |
| American Statistical Association, Member | 2008 - Present |
| American Heart Association, Member | 2003 - Present |
| Alpha Chi Sigma Professional Chemistry Fraternity, Member, Historian | 1996 - 1998 |
Committee Service
| Second-Year Qualifying Examination Committee for Taylor Ward, Member | 2022 - 2022 |
| Second-Year Qualifying Examination Committee for David Lee, Member | 2022 - 2022 |
| Academy of Academic Excellence, Member | 2022 - Present |
| Second-Year Qualifying Examination Committee for Jack Liu, Member | 2022 - 2022 |
| MEDICAL CENTER-FACULTY SENATE, President | 2022 - 2023 |
| School of Population Health Awards and Recognition Committee, Member | 2022 - Present |
| Second-Year Qualifying Examination Committee for Tran Le, Member | 2021 - 2021 |
| Second-Year Qualifying Examination Committee for Mengna Zhang, Member | 2021 - 2021 |
| Second-Year Qualifying Examination Committee for Quest Whalen, Chair | 2021 - 2021 |
| MEDICAL CENTER-FACULTY SENATE, Secretary | 2021 - 2022 |
| SCHOOL OF POPULATION HEALTH - ACADEMIC COUNCIL, Member | 2021 - Present |
| UMMC Faculty Senate Task Force on Diversity and Inclusion, Member | 2020 - Present |
| UMMC Faculty Senate Task Force on Diversity and Inclusion, Task Force Chair | 2020 - 2021 |
| MEDICAL CENTER-FACULTY SENATE, Member | 2020 - Present |
| Second-Year Qualifying Examination Committee for Md Roungu Ahmmad, Member | 2020 - 2020 |
| Second-Year Qualifying Examination Committee for Phi Le, Member | 2020 - 2020 |
| Second-Year Qualifying Examination Committee for Yan Gao, Chair | 2020 - 2020 |
| Second-Year Qualifying Examination Committee for Shamsed Mahmud, Chair | 2020 - 2020 |
| Second-Year Qualifying Examination Committee for Md. Mohiuddin Adnan, Member | 2019 - 2019 |
| Distinguished Population Health Lectureship Committee, John D Bower School of Population Health, Member | 2018 - 2019 |
| Biostatistician Search/Curriculum Vitae Committee, Department of Data Science, School of Population Health, Member | 2018 - Present |
| Curriculum Committee, School of Population Health, Member | 2017 - 2020 |
| First-Year Qualifying Exam Committee, Biostatistics & Data Science PhD Program, Chair | 2017 - Present |
| Admissions Commitee, Biostatistics & Data Science Graduate (PhD and MS) Programs, Chair | 2017 - 2020 |
| Academic/Leadership Council, School of Population Health, Member | 2017 - 2020 |
| Curriculum Committee, Biostatistics & Data Science Graduate (PhD and MS) Programs (except 02/13/2019-05/28/2019), Chair | 2017 - 2020 |
| Curriculum Committee, Biostatistics and Data Science (PhD and MS) Programs, School of Population Health, Member | 2016 - Present |
| Admissions Committee, Biostatistics and Data Science Graduate (PhD and MS) Programs, School of Population Health, Member | 2016 - Present |
| Faculty Search Committee, Department of Data Science, School of Population Health, Member | 2015 - 2021 |
| Admissions Committee, Division of Biostatistics, Washington University School of Medicine, Member | 2013 - 2014 |
Community Service
| EversCare Food Pantry, Volunteer | 12/2019 - 12/2019 |
| Alzheimer's Association Walk Participant (part of Team MIND Center); Annually | 09/2015 - Present |
Other Service
| Frontiers in Dementia, Review Editor | 06/2022 - Present |
| University of Mississippi Medical Center Student Chapter of the American Statistical Association, Faculty Advisor | 10/2019 - 08/2022 |
| ARIC Study Manuscripts, Ad Hoc Reviewer | 08/2016 - Present |
| American Society of Human Genetics DNA Day Essay Contest, Round 1 Judge (Annually) | 03/2016 - Present |
| Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Cognitive Working Group, Secretary | 2015 - 02/2019 |
| Biostatistics Seminar Series, Coordinator | 11/2012 - 06/2014 |
| PLoS Genetics, Ad Hoc Reviewer | |
| American Journal of Human Genetics, Ad Hoc Reviewer | |
| American Journal of Hypertension, Ad Hoc Reviewer | |
| Jackson Heart Study Manuscript, Ad Hoc Reviewer | |
| Atherosclerosis, Ad Hoc Reviewer | |
| Genetic Epidemiology, Ad Hoc Reviewer | |
| Center for Psychiatric Neuroscience, Center of Biomedical Research Excellence (COBRE) Pilot Program, University of Mississippi Medical Center, Grant Proposal Reviewer |
Teaching Experience
| BDS 741, Population Health, Course, Course Director, BDS 741: Statistical Inference I | Fall 2022 |
| BDS 797, Population Health, Course, Course Director, BDS 797: Biostatistics & Data Science Internship | Summer 2021 - 2021 |
| Population Health, Course, Course Director, BDS 741: Statistical Inference I | Fall 2021 |
| BDS 797, Population Health, Course, Course Director, BDS 797: Biostatistics and Data Science Internship | Summer 2020 - 2020 |
| BDS 761, Population Health, Course, Co-Course Director, BDS 761: Data Science | Spring 2020 - 2020 |
| BDS 741, Population Health, Course, Course Director, BDS 741: Statistical Inference I | Fall 2020 - 2020 |
| BDS 791, Population Health, Course, Course Director, BDS 791: Special Topics (Independent Study of Convolutional Neural Networks) | Fall 2020 - 2020 |
| BDS 741, Population Health, Course, Course Director, BDS 741: Statistical Inference I | Fall 2019 - 2019 |
| BDS 796, Population Health, Course, Course Director, BDS 796: Directed Research | Fall 2019 - 2019 |
| BDS 797, Population Health, Course, Course Director, BDS 797: Biostatistics & Data Science Internship | Summer 2018 - 2018 |
| MSCI 711, Graduate, Lecture, Guest Presenter, MSCI 711: Epidemiology II | Spring 2018 - 2018 |
| BDS 741, Population Health, Course, Course Director, BDS 741: Statistical Inference I | Fall 2018 - 2018 |
| MSCI 711, Graduate, Lecture, Guest Presenter, MSCI 711: Epidemiology II | Spring 2017 - 2017 |
| BDS 741, Population Health, Course, Course Director, BDS 741: Statistical Inference I | Fall 2017 - 2017 |
Directed Student Learning
| Doctoral Advisory Committee Member, Advised: Xiaojian (Jack) Liu | 2022 - Present |
| Dissertation Committee Member, Advised: Tran Le | 2021 - Present |
| Dissertation Committee Member, Advised: Mengna Zhang | 2021 - Present |
| Dissertation Committee Member, Advised: Quest Whalen | 2021 - Present |
| Internship Advisor, Advised: Quest Whalen | 2021 - Present |
| Internship Advisor, Advised: Jenny Ogden | 2021 - 2021 |
| Doctoral Advisory Committee Chair, Continuity of Care in Patients with Obesity-Associated Chronic Conditions Advised: Phi Le | 2020 - Present |
| Academic Advisor, Advised: Phi Le | 2020 - Present |
| Doctoral Advisory Committee Chair, Obesity in Blacks in the Southern US: Demographic Correlates and Associations with CVD incidence in Jackson Heart Study Advised: Yan Gao | 2020 - 2022 |
| Academic Advisor, Advised: Kendall Niles | 2020 - 2021 |
| Academic Advisor, Advised: Jenny Ogden | 2020 - Present |
| Academic Advisor, Advised: Mengna Zhang | 2020 - Present |
| Doctoral Advisory Committee Member, Genomic Prediction of Complex Phenotypes in Pathogenic Bacteria Advised: Iftekhar M Rafiqullah | 2020 - Present |
| Doctoral Advisory Committee Chair, Genetic Architecture of Mild Cognitive Impairment in ARIC-NCS Advised: Shamsed Mahmud | 2020 - 2022 |
| Doctoral Advisory Committee Member, A Classification and Design Framework for Run-in Phases in Comparative Therapeutic Efficacy (CTE) Trials with Quantitative Performance Assessment Advised: Md. Mohiuddin Adnan | 2019 - 2022 |
| Academic Advisor, Advised: Kendell Churchwell | 2019 - Present |
| Doctoral Advisory Committee Member, Comparison of Different Approaches to Estimate Glomerular Filtration Rate Advised: Xiaoqian (Jenna) Zhu | 2019 - 2022 |
| Academic Advisor, Advised: Morenike Irving | 2018 - 2018 |
| Academic Advisor, Advised: Shamsed Mahmud | 2018 - Present |
| Internship Advisor, Advised: Yan Gao | 2018 - 2019 |
| Internship Advisor, Advised: Shamsed Mahmud | 2018 - 2019 |
| Academic Advisor, Advised: Yan Gao | 2017 - Present |