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Cardiorenal and Metabolic Diseases Research Center

The Cardiorenal and Metabolic Diseases Research Center (CMDRC) at the University of Mississippi Medical Center has been supported for over 10 years by an award from the National Institute of General Medical Sciences (NIGMS). The NIGMS is a part of the National Institutes of Health (NIH) that supports thematic, multidisciplinary Centers of Biomedical Research Excellence (COBRE) across the country through its Institutional Development Award (IDeA) program.

Cardiovascular, renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. These disorders usually cluster together and are highly interdependent. For example, obesity and associated metabolic disorders, such as diabetes, are major causes of cardiovascular and renal disease.

A major objective in developing the Cardiorenal and Metabolic Diseases Research Center is to provide infrastructure for a multidisciplinary, diverse group of basic, clinical and population scientists working on the common synergistic theme of obesity, cardiorenal and metabolic diseases and to facilitate their collaborations.


Congratulations to Dr. Alexandre da Silva on receiving an R01 from the National Heada-Silva,-Alex-150x175.jpgrt, Lung and Blood Institute NIH/NHLBI. Dr. da Silva's grant titled "Cardiac protective mechanisms of melanocortin system activiation" will test the hypothesis that activation of brain melanocortin 4 receptors improve cardiac function and protect the heart against progressive heart failure after myocardial infarction.