Jan M. Williams, PhD
Professor
Department:
SOM-Pharmacology/Toxicology
Email:
jmwilliams5@umc.edu
Work Phone:
(601) 984-1175
Education
| Medical College of Wisconsin, Postdoctoral Fellowship, Hypertension-induced renal disease | 2009 |
| Medical College of Georgia, PhD, Biomedical Sciences | 2005 |
| Georgia Southern University, BS, Chemistry | 1999 |
Current Positions
| Associate Professor, School of Medicine, Department of Pharmacology / Toxicology | 07/2015 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 10/2009 - 06/2015 |
| Assistant Professor, Medical College of Wisconsin, School of Graduate, Department of Physiology And Biophysics | 05/2009 - 09/2009 |
Sponsored Program Funding
| Extramural, Mechanisms involved in the early development of renal disease associated with prepubertal obesity, NIDDK | 06/2017 - 04/2022 |
| Extramural, Cardiorenal and Metabolic Disease Center, NIH | 09/2013 - 04/2018 |
| Extramural, Discovering new therapies for the treatment of diabetic nephropathy, AHA | 01/2012 - 12/2015 |
| Extramural, Matrix Metalloproteinases in Diabetic Nephropathy, PhRMA Foundation | 01/2011 - 12/2011 |
| Intramural, Mechanisms of Diabetic Nephropathy, UMMC | 11/2010 - 10/2011 |
| Extramural, Blood Pressure: Determinants and Controllers, NIH | 09/2009 - 08/2011 |
Publications
Abstracts | |
| Denise C Cornelius, Olivia Travis, Dakota White, Cedar Baik, Willie Thompson, Chelsea Giachelli, Jan Michael Williams, Babbette LaMarca IL-17 Signaling Mediates Cytolytic Natural Killer Cell Activation in Response to Placental Ischemia AHA Hypertension Council 2019 Scientific Sessions | 2019 |
| Travis O, Baik C, Jackson C, Giachelli C, Williams JM, Cornelius DC Cytolytic Natural Killer Cells Play a Direct Role in Causing Hypertension and Intrauterine Growth Restriction in Pregnant Rats AHA Hypertension Council 2019 Scientific Sessions | 2019 |
| Cornelius DC, Travis O, White D, Baik C, Thompson W, Giachelli C, Williams JM Suppression of TH17 Cells Blunts Preeclampsia-Associated Cytolytic Natural Killer Cells during Pregnancy 2019 Experimental Biology, Orlando, FL | 2019 |
| Shields CA, Poudel B, Browning E, and Williams JM Effects of Gemfibrozil on the Progression of Proteinuria in Obese Dahl Salt-Sensitive Rats Volume 33, Issue 1_supplement01 Apr 2019, The FASEB Journal | 2019 |
| Poudel B, Shields CA, Pennington AP, Cornelius DC, and Williams JM Depletion of macrophages with clodronate partially reduces the progression renal injury in obese Dahl salt-sensitive rats during prepubertal obesity Volume 33, Issue 1_supplement01 Apr 2019, The FASEB Journal | 2019 |
| Pennington AP, Poudel B, Shields CA, Thompson WL, Williams JM Treatment with lisinopril slows the early progression of proteinuria in obese Dahl salt-sensitive rats independent of lowering arterial pressure and GFR Volume 33, Issue 1_supplement01 Apr 2019, The FASEB Journal | 2019 |
| Borges-Rodriguez M, Tramel R, Travis OK, Baik C, Greer M, Lemon JP, Williams JM, Cornelius DC Platelet Inhibition Prevents NLRP3 Inflammasome Activation and Sepsis-Induced Multi-Organ Injury 2019 Society of Critical Care Meeting, San Diego, CA | 2019 |
| Williams JM, McPherson KC, Shields CA, Poudel B, Cornelius DC, Garrett MR Early Renal Hyperfiltration in Obese Dahl Salt-Sensitive Leptin Receptor Mutant Rats is Associated with Glomerular Leukocyte Extravasation and Renal Disease 2018; Hypertension Volume 72, Issue Suppl_1 | 2018 |
| Travis O, White D, Pierce WA, Ge Y, Young C, Spradley F, Williams JM, Cornelius DC Interleukin-17 Mediates Hypertension, Intrauterine Growth Restriction, Cytolytic Natural Killer Cells and Vascular Dysfunction in Pregnant Rats AHA Hypertension Council 2018 | 2018 |
| Poudel B, Shields CA, Cornelius DC, and Williams JM Sex Differences in the Development of Renal Injury in Obese SSLepRmutant Rats during Prepubertal Obesity FASEB J. 2018 April; 32:906.5 | 2018 |
| Shields CA, Poudel B, McPherson KC, Garrett MR, and Williams JM Altered Immune Cell Programming in the Kidneys of Obese SSLepRmutant Rats Prior to Puberty FASEB J. 2018 April; 32:718.13 | 2018 |
| Wallace K, Szczepanski J, Spencer S, Williams JM, Jayaram A, and Novotny S Acute Kidney Injury in Pregnancy and HELLP Syndrome FASEB J. 2018 April; 32:LB347 | 2018 |
| 13. McPherson K, Pennington A, and Williams JM Treatment with Lisinopril Delays the Early Progression of Proteinuria in a Novel Model of Prepubertal Obesity | 2017 |
| McPherson K, Taylor L, Spires D, Johnson A, Guillory D, Garrett MR, and Williams JM. Decreased survival rate in female obese leptin receptor mutant Dahl salt-sensitive rats that develop chronic kidney disease. Hypertension Scientific Sessions 2015 | 2015 |
| McPherson K, Taylor L, Spires D, Szabo-Johnson A, and Williams JM. Evaluation of endothelin A receptor (ETA) blockade on the progression of renal injury in various models of metabolic disorders with pre-existing renal disease. Endothelin 14 Meeting 2015 | 2015 |
| McPherson K, Cornelius D, Thomas D, Taylor L, Spires D, Johnson A, Lamarca B, Garrett MR, and Williams JM. Early development of glomerular injury in Dahl salt-sensitive rats with metabolic syndrome independent of diabetes and hypertension. FASEB J April 2015 29:964.8 | 2015 |
| Taylor L, Fizer B, McPherson K, and Williams JM. The effects of atorvastatin on the progression of metabolic syndrome associated kidney disease. FASEB J April 2015 29:964.4 | 2015 |
| Spires D, Taylor L, McPherson K, and Williams JM. Effects of Endothelin-A Receptor and Angiotensin Converting Enzyme Inhibition on the Development of Progressive Proteinuria in Diabetic Dahl SS Rats with Pre-existing Renal Disease FASEB J April 2015 29:959.8 | 2015 |
| Murphy S, Wu W, White TN, Williams JM, Mayoux E, and Roman RJ Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy with hypertension Diabetes June 2014 63: Supplement 1 A217:850-P | 2014 |
| McPherson K, White TN, Johnson A, Geurts AM, Jacob HJ, Garrett MR and Williams JM Initial characterization of leptin receptor knockout Dahl salt-sensitive (SS) rats | 2014 |
| White TN, Spires D, Roman RJ and Williams JM Effects of hyperglycemia and cyclic stretching on MMP-2 and TGF-β in rat mesangial cells | 2014 |
| Spires D, White TN, Taylor L and Williams JM Contrasting differences of chronic endothelin A receptor (ETA) blockade during the progression of renal injury in type-1 and type-2 diabetic nephropathy | 2014 |
| Slaughter TN, Kojima N, Roman RJ and Williams JM Alterations in renal hemodynamics are associated with increased renal MMP-2 expression during the early phase of diabetic nephropathy Faseb J 27: 1183.2, 2013 | 2013 |
| Spires D, Slaughter TN, Taylor L and Williams JM Chronic ETA receptor blockade prevents the progression of renal injury in diabetic Dahl salt-sensitive (SS) rats Faseb J 27: 702.10, 2013 | 2013 |
| Gillis E, Mooney J, Roman RJ, Williams JM and Sasser JM Using the T2DN rat as a model to determine therapeutic efficacy of Serelaxin (recombinant human relaxin-2) for Diabetic Nephropathy Faseb J 27:LB889, 2013 | 2013 |
| Kojima N, Williams JM, Takahashi T, Miyata N and Roman RJ Renoprotective effects of SGLT2 inhibitor, Luseogliflozin, on the progression of diabetic nephropathy in T2DN rats Hypertension. 2012;60:A221 | 2012 |
| Slaughter TN, Paige A, Fan F, Kyle PB, Geurts AM, Howard JJ, Roman RJ and Williams JM Involvement of MMP-2 during the progression of renal disease in diabetic Dahl salt-sensitive rats Hypertension. 2012;60:A55 | 2012 |
| Williams JM, Slaughter TN, Paige A, Chen CC, Fan F, Geurts AM, Howard JJ, Roman RJ The role of MMP-2 during the development of hypertension-induced renal injury Dahl salt-sensitive rats Hypertension. 2012;60:A347 | 2012 |
| Slaughter TN, Paige A, Rucker C, Kyle PB, Kojima N, Garrett MR, Roman RJ and Williams JM Temporal characterization of the development diabetic-induced renal disease in strains of Goto-Kakizaki rats Hypertension. 2012;60:134 | 2012 |
| Williams JM, Slaughter TN, Wells A, Rucker C, Spires D, Kyle PB and Roman RJ Increased MMP-9 activity during the progression of renal injury in Type-2 Diabetic Nephropathy rats Faseb J 26: 687.4, 2012 | 2012 |
| Slaughter TN, Spires D, Rucker C, Wells A, Kyle PB, Roman RJ and Williams JM The reduction of renal injury in diabetic Dahl salt-sensitive rats with insulin is associated with decreased MMP activity Faseb J 26: 687.3, 2012 | 2012 |
| Williams JM, Wells A, Spires D. The progression of diabetes-induced renal injury in Dahl salt-sensitive rats Faseb J 25: 664.7, 2011 | 2011 |
Book Chapter | |
| Williams JM, Poudel B, Shields CA. Sex Differences in Autoimmune Type-1 Diabetes. In: Sex Differences in Cardiovascular Physiology and Pathophysiology. | 2019 |
| Williams JM and Pollock DM. Renal Endothelin In: Handbook of Biologically Active Peptides A.J. Kastin, Editgor, Elsevier, San Diego, 2006 | 2006 |
Presentations
| National and International Invited Seminars/Lectures, Sex differences in renal injury in a rat model of prepubertal obesity, APS, Knoxville, TN | 10/2018 |
| Regional Invited Seminars/Lectures, Using animal models to explore mechanisms involved in the development of renal disease associated with obesity, Fort Worth, TX | 08/2018 |
| State/Local Invited Seminars/Lectures, Using animal models to explore mechanisms involved in the development of renal disease associated with obesity, Jackson, MS | 02/2018 |
| National and International Invited Seminars/Lectures, Discovering mechanisms involved in the development of renal injury associated with prepubertal obesity, Renal Hemodynamics and Cardiovascular Function in Health and Disease, FASEB, Big Sky, MT | 06/2016 |
| Invited Symposia, Involvement of MMPs in the progression of diabetic nephropathy, FASEB Summer Conference, Saxtons River, VT | 07/2013 |
| Poster Presentation, The role of MMP-2 during the development of hypertension-induced renal injury Dahl salt-sensitive rats, High Blood Pressure Council Meeting, Wasington, D.C. | 09/2012 |
| Invited Symposia, Involvement of MMP-2 during the progression of renal disease in diabetic Dahl salt-sensitive rats, High Blood Pressure Council Meeting, Washington, D.C. | 09/2012 |
| Poster Presentation, Temporal characterization of the development diabetic-induced renal disease in strains of Goto-Kakizaki rats, High Blood Pressure Council Meeting, Washington, D.C. | 09/2012 |
| State/Local Invited Seminars/Lectures, Using genetic rodent models to study diabetic nephropathy, Augusta, GA | 06/2012 |
Honors, Awards, and Recognition
| Excellence in Research Award at the University of Mississippi Medical Center, UMMC | 2016 |
| Excellence Research Award, University of Mississippi Medical Center | 2014 |
| Fellow of the American Heart Association, American Heart Association | 2012 |
| Outstanding Poster Award, 12th Winter Eicosanoid Conference 2010 | 2010 |
| FASEB Young Investigator Award, FASEB Summer Conference 2007 | 2007 |
| UNCF Merck Postdoctoral Fellowship Award, UNCF-Merck Foundation | 2006 |
| The American Physiological Society Minority Travel Fellowship Award, Experimental Biology 2005 | 2005 |
| Forest Pharmaceutical New Investigator Travel Award, Cardiovascular-Renal Meeting 2008 | |
| Kidney Council New Investigator Award, High Blood Pressure Research Conference 2008 | |
| Who's Who Among Students in American College and Universities | |
| Award of Excellence in Physiology, Graduate Research Day 2004 | |
| Award of Excellence in Physiology, Medical College of Georgia, Graduate Reserach Day 2004 | |
| American Physiological Society Water and Electrolyte Award, Experimental Biology 2003 | |
| The American Physiological society Minority Travel Fellowship Award, Experimental Biology 2003 | |
| The American Physiological "Society Minority Travel "Fellowship Award, Experimental Biology 2002 |
Professional Membership and Service
| American Heart Association, Member | 2006 - Present |
| American Physiological Society, Member, Water and Electrolyte | 2004 - Present |
Committee Service
| Department of Pharmacology Admissions and Curriculum Committee, Chair | 2019 - Present |
| Department of Pharmacology Promotion and Tenure Committee, Vice Chair | 2017 - Present |
| AHA Vascular Endothelial Biology – Clinical Peer Review Committee, Chair | 2017 - Present |
| Medical Student Research Program Committee, Member | 2016 - Present |
| American Physiological Society Porter Physiology Development & Minority Committee, Member | 2016 - Present |
| AHA Vascular Endothelial Biology – Clinical Peer Review Committee, Member | 2015 - 2016 |
| Department of Pharmacology Graduate Admissions and Curriculum Committee, Member | 2013 - 2019 |
| American Heart Association Cardiorenal 3 Peer Review Committee, Member | 2013 - 2015 |
| UMMC Graduate School Alumni Committee, Member | 2012 - 2015 |
| American Physiological Society Awards Committee, Member | 2011 - 2014 |
Community Service
| Wolfpack Youth Basketball Program, Organizer and Mentor | 2013 - Present |
Other Service
| PLOS ONE Journal | 07/2016 - Present |
| AJP Renal Physiology | 07/2015 - Present |
| SURE Program, Mentor | 06/2015 - Present |
| AJP Regulatory Integrative Comparative Physiology | 07/2011 - Present |
| Journal of Hypertension | 07/2011 - Present |
| Base Pair Program, Mentor | 2010 - Present |
| Hypertension | 07/2009 - Present |
Teaching Experience
| Graduate, Course, Lecturer, Fundamental Pharmacology | Spring 2019 |
| Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2019 |
| Graduate, Course, Lecturer, Experimental Design and Methods | Spring 2019 |
| Graduate, Course, Lecturer, Fundamental Pharmacology | Spring 2018 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2018 |
| Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2018 |
| Graduate, Course, Lecturer, Experimental Design and Methods | Spring 2018 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2017 |
| Graduate, Course, Lecturer, Mechanisms of Drug Actions | Spring 2017 |
| PHARM 726, Graduate, Course, Lecturer, Fundamental Pharmacology | Spring 2017 |
| PHARM 724, Graduate, Course, Lecturer, Experimental Design and Methods | Spring 2017 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2016 |
| Dentistry, Course, Lecturer, Dental Pharmacology | Spring 2016 |
| Graduate, Course, Lecturer, Mechanisms of Drug Actions | Spring 2016 |
| Dentistry, Lecture, Lecturer, Dental Pharmacology | Spring 2015 |
| Graduate, Lecture, Lecturer, Mechanism of Drug Action | Spring 2015 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2015 |
| Dentistry, Lecture, Lecturer, Dental Pharmacology | Spring 2014 - 2014 |
| Graduate, Lecture, Lecturer, Mechanisms of Drug Action | Spring 2014 - 2014 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2014 |
| Graduate, Lecture, Lecturer, Mechanisms of Drug Action | Spring 2013 - 2013 |
| Dentistry, Lecture, Lecturer, Dental Pharmacology | Spring 2013 - 2013 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2013 |
| Dentistry, Course, Assistant Course Director, Dental Pharmacology | Annual 2013 |
Directed Student Learning
| Dissertation Committee Chair, The role of macrophages in the progression of renal injury associated with obesity Advised: Bibek Poudel | 2018 - Present |
| Dissertation Committee Chair, Effects of glomerular hyperfiltration on lipid accumulation during the progression renal injury associated with obesity Advised: Corbin Shields | 2018 - Present |
| Research Advisor, Effects of lisinopril on the development of renal injury associated with obesity Advised: Alyssa Pennington | 2016 - 2019 |
| Research Advisor, Role of dyslipidemia in chronic kidney disease Advised: Brianca Fizer | 2014 - 2014 |
| Research Advisor, Effects of statin therapy on the development of diabetic nephropathy Advised: Destenee Green | 2014 - 2014 |
| Dissertation Defense Committee Chair, Evaluating temporal changes in renal hemodynamics during obesity related kidney disease Advised: Kasi McPherson | 2013 - 2017 |
| Research Advisor, Inflammation during diabetic nephropathy Advised: Judson Womack | 2013 - 2014 |
| Research Advisor, Role of TNF-alpha in the development of diabetic kidney disease Advised: Alyssa Pennington | 2013 - 2014 |
| Research Advisor, Effects endothelin receptor A blockade on the progression diabetes-induced renal disease Advised: Denisha Spires | 2012 - 2015 |
| Research Advisor, Inhibition of MMP activity on kidney disease associated with diabetes Advised: Carlos Rucker | 2012 - 2013 |
| Dissertation Defense Committee Chair, Role of MMP-2 in the Progression of Diabetes-inudced Renal Disease Advised: Tiffani White | 2011 - 2014 |
| Research Advisor, The effects of high fat diet on the development of renal disease in diabetic Dahl salt-sensitive rats Advised: Denisha Spires | 2010 - 2011 |