Zhen Wang
Assistant Professor
Department:
SOM-Physiology & Biophysics
Email:
zwang3@umc.edu
Work Phone:
(601) 984-1250
Biography
My long term career goal is to become an independent scientist in the area of cardiovascular and kidney research in an academic environment that involves both research and teaching. My academic training and research experiences have provided me with an excellent background in multiple biological disciplines including molecular biology, pharmacology, and physiology. One of my M.S. research projects used the yeast two-hybrid system to identify the protein interactions of a novel gene. This project helped me to learn numerous molecular and cell biology experimental skills. As a Ph.D. student with Dr. Philip Mayeux, my research focused on the mechanisms of renal microcirculatory failure during sepsis-induced acute kidney injury. From this project, I gained expertise in animal surgical procedures and measuring kidney function. For my postdoctoral training, I joined Dr. John Hall’s laboratory, Dr. Hall, is an internationally recognized leader in cardiovascular physiology and he has an extensive record for training postdoctoral fellows. He introduced me to a new research area aimed at revealing how the CNS leptin signaling pathway differentially regulates blood pressure and metabolism. I gained additional expertise in small animal surgical procedures and broadened my knowledge related to physiology of the CNS and cardiorenal systems. In 2014, I received an AHA postdoctoral fellowship for my second project which examined the synergistic effects of hypertension and diabetes to promote kidney injury. In 2017, I received K99 grant from NIDDK for the project-synergistic interactions of hypertension and diabetes in promoting kidney injury.
Education
| University of Arkansas for Medical Sciences, PhD, Pharmacology and Toxicology | 2007 |
| Tongji Medical College, Huazhong University of Science and Technology, MS, Pharmacology | 2001 |
| Tongji Medical College, Huazhong University of Science and Technology, BS, Medicine | 1994 |
Current Positions
| Instructor, School of Graduate School in the Health Sciences, Department of Physiology And Biophysics | 2014 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Sponsored Program Funding
| Extramural, Synergistic interactions of hypertension and diabetes in promoting kidney injury, NIH/NIDDK | 05/2017 - 05/2019 |
Publications
Journal Article | |
| Jussara M. do Carmo, Alexandre A. da Silva, John Nathan Freeman, Zhen Wang, Sydney P. Moak, Michael W. Hankins, Heather A. Drummond, John E. Hall. Neuronal SOCS3 (Suppressor of Cytokine Signaling 3) Role in Modulating Chronic Metabolic and Cardiovascular Effects of Leptin Hypertension. 2018; 71:00-00 | 2018 |
| Nicola Aberdein, Robert J Dambrino, Jussara M. do Carmo, Zhen Wang, Laura E Mitchell, Heather A Drummond, and John E. Hall. Role of PTP1B in POMC Neurons during Chronic High Fat Diet: Sex Differences in Regulation of Liver Lipids and Glucose Tolerance AJP- Regulatory, Integrative and Comparative Physiology. 2018; Mar 1;314(3):R478-R488 | 2017 |
| Zhen Wang, Jussara M. do Carmo, Nicola Aberdein, Xinchun Zhou, Jan M. Williams, Alexandre A. da Silva, John E. Hall. Synergistic Interaction of Hypertension and Diabetes in Promoting Kidney Injury and the Role of Endoplasmic Reticulum Stress Hypertension. 2017; May;69(5):879-891. | 2017 |
| Jussara M. do Carmo, Alexandre A. da Silva, Zhen Wang, Nathan J. Freeman, Ammar J. Alsheik, Ahmad Adi, John E. Hall Regulation of Blood Pressure, Appetite, and Glucose by Leptin After Inactivation of Insulin Receptor Substrate 2 Signaling in the Entire Brain or in Proopiomelanocortin Neurons Hypertension. 2016; 67: 378-386. PMID:26628674. | 2016 |
| Zhen Wang, Clark R. Sims, Naeem K. Patil, Neriman Gokden and Philip R. Mayeux. Pharmacological Targeting of Sphingosine-1-Phosphate Receptor 1 Improves the Renal Microcirculation During Sepsis in the Mouse. J Pharmacol Exp Ther. 2015 January:352:61–66. | 2014 |
| Zhen Wang, Joseph H. Holthoff, Kathryn A. Seely, Horace J. Spencer, III, Neriman Gokden, Philip R. Mayeux. Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury Am J Pathol. 2012 Feb;180(2):505-516. | 2012 |
| Zhen Wang, Christan Herzog, Gur P. Kaushal, Neriman Gokden, Philip R. Mayeux. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis Shock. 2011 Feb;35(2):141-147. | 2011 |
Review Article | |
| John E. Hall, Jussara M. do Carmo, Alexandre A. da Silva, Zhen Wang and Michael E. Hall. Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms Circulation Research. 2015; 116:991-1006. | 2015 |
| Alexandre A. da Silva, Jussara M. do Carmo, Zhen Wang, and John E. Hall. The Brain Melanocortin System, Sympathetic Control and Obesity Hypertension Physiology. 2014 29:196-202. | 2014 |
Abstracts | |
| Zhen Wang, Jussara M. do Carmo, Nicola Aberdein, Taolin Fang, John E. Hall. The Role of TRPC6 Channels in Glomerular Capillary Endothelial Cell Injury Induced by Mechanic Stretch and High Glucose The FASEB Journal. 2017; Volume 31, Issue 1_supplement:Pages lb1-1091.2 | 2017 |
| Zhen Wang, Jussara M. do Carmo, Alexandre A. da Silva, Nicola Aberdein, John E. Hall. Role of Suppressor of Cytokines Signaling 3 (SOCS3) in POMC Neurons in Regulating Metabolic and Cardiovascular Functions in Dietary-Induced Obesity Hypertension. 2016;68:A077 | 2016 |
| Zhen Wang, Jussara M. do Carmo, John E. Hall. ER Stress and Mitochondrial ROS Contribute to the Development of Hypertensive-Diabetic Nephropathy The FASEB journal; Vol. 30, No. 1_supplement | 2016 |
Presentations
| National and International Invited Seminars/Lectures, Role of Suppressor of Cytokine Signaling 3 (SOCS3) in POMC Neurons in Metabolic and Cardiovascular Regulation during Chronic Leptin Infusion, Experimental Biology, San Diego | 04/2018 |
| National and International Invited Seminars/Lectures, The Role of TRPC6 Channels in Glomerular Capillary Endothelial Cell Injury Induced by Mechanic Stretch and High Glucose, Experimental Biology, Chicago | 04/2017 |
| National and International Invited Seminars/Lectures, Role of Suppressor of Cytokines Signaling 3 (SOCS3) in POMC Neurons in Regulating Metabolic and Cardiovascular Functions in Dietary-Induced Obesity, AHA Council on Hypertension Scientific Sessions/AHA, Orlando | 09/2016 |
| National and International Invited Seminars/Lectures, Mechanisms of Hypertensive Diabetic Nephropathy: Role of Mitochondrial Dysfunction and ER Stress, Kidney week/ASN, Philadelphia | 09/2014 |
Honors, Awards, and Recognition
| Trustmark Postdoctoral Publication Award, School of Graduate Studies in the Hearth Sciences, University of Misssissippi Medical Center | 2017 |
| APS Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award, American Physiological Society | 2015 |
| American Heart Association, Postdoctoral Fellowship, American Heart Association | 2014 |
| Society for Experimental Biology and Medicine (SEBM) Young Investigator Award, Society for Experimental Biology and Medicine | 2011 |
Professional Membership and Service
| American Heart Association, Member | 2012 - Present |
| American Physiological Society, Member | 2010 - Present |
Directed Student Learning
| Supervised Research, Advised: Kandice Bailey | 2017 - 2017 |