David E. Stec

David E. Stec

Professor

Department:
SOM-Physiology & Biophysics

Email:
dstec@umc.edu

Work Phone:
(601) 815-1859

Education

University of Iowa, Molecular Genetics2000
Medical College of Wisconsin, PhD, Physiology1996
University of Scranton, BS, Biology1991

Current Positions

Director, School of Medicine07/2023 - Present
Professor, School of Medicine, Department of Physiology And Biophysics07/2017 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Physiology And Biophysics07/2009 - 06/2017
Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Physiology And Biophysics06/2001 - 06/2009

Sponsored Program Funding

Extramural, Novel Liver Signaling Pathways Controlling Adiposity, NIH-NIDDK07/2020 - 06/2024
Extramural, Integrative role of Bilirubin on Obesity, NIH-NIDDK04/2020 - 01/2024
Extramural, Novel molecules for the treatment of obesity, NIH-NIDDK02/2017 - 01/2021
Extramural, Novel protective mechanism of bilirubin in Type II diabetes, American Diabetes Association Basic Science Grant01/2017 - 12/2020
Extramural, Cardiovascular dynamics and their control. Project 1, Neurohumoral and renal mechanisms of hypertension, National Institutes of Health/National Heart, Lung, Blood Institute08/2014 - 05/2019
Extramural, Tubuloglomerular feedback and salt-sensitive hypertension, NIH-NHLBI09/2013 - 08/2018
Extramural, Cardiorenal and Metabolic Diseases Research Center, NIH/NIGM09/2013 - 04/2018
Extramural, Hypertension, Kidney and Pregnancy, National Institutes of Health/NHLBI04/2011 - 12/2015
Extramural, The Renal Medulla and Hypertension, NIH/NHLBI07/2009 - 06/2011
Extramural, The Renal Medulla and Hypertension, National Institutes of Health/National Heart,Lung, Blood Institute09/2008 - 08/2013
Extramural, Vascular Mechanosensor, National Institutes of Health/National Heart, Lung, Blood Institute07/2007 - 06/2011
Extramural, Role of renal medullary HO-1 in blood pressure regulation, American Heart Association07/2007 - 06/2009
Extramural, Abnormal Pressure Natriuresis in Hypertension, National Institutes of Health/National Heart,Lung, Blood Institute01/2006 - 12/2009

Publications

Journal Article

Kipp ZA, Martinez GJ, Bates EA, Maharramov AB, Flight RM, Moseley HNB, Morris AJ, Stec DE, Hinds TD Jr. Bilirubin nanoparticle treatment in obese mice inhibits hepatic ceramide production and remodels liver fat content. Metabolites 13(2):215, 2023.2023
Bates EA, Kipp ZA, Martinez GJ, Badmus OO, Soundarapandian MM, Foster D, Xu M, Creeden JF, Greer JR, Morris AJ, Stec DE, Hinds TD Jr. Suppressing hepatic UGT1A1 increases plasma bilirubin, lowers plasma urobilin, and improves fatty liver disease by reorganizing kinase signaling pathways. Biomolecules 13(2):252, 20232023
Martin BE, Taylor EB, Attipoe EM, Wu W, Stec DE, Showmaker KC, Garrett MR. Sex and molecular differences in cardiovascular parameters at peak influenza disease in mice. Physiol Genomics 55(2):79-89, 2023.2023
Lu Y, Stec DE, Liu R, Ryan MJ, Drummond HA βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole Am. J. Physiol. Renal Physiol. 322(5):F498-F511, 2022.2022
Hinds TD Jr., Kipp ZA, Xu Z, Yiannikouris FB, Morris AJ, Stec DF, Wahli W, Stec DE Adipose-specific PPARα knockout mice have increased lipogenesis by PASK-SREBP1 signaling and a polarity shift to inflammatory macrophages in white adipose tissue (WAT) Cells, 11(1):4, 2021.2021
Braud L, Pini M, Stec DF, Manin S, Derumeaux G, Stec DE, Foresti R, Motterlini R. Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice. Redox Biology. Jan;38:101805, 20212021
Hinds TD Jr., Creeden JF, Gordon DM, Stec DF, Donald MC, Stec DE. Bilirubin nanoparticles reduce diet-induced hepatic steatosis, improve fat utilization, and increase plasma β-hydroxybutyrate. Frontiers in Pharmacology. Dec 18;11:594574, 2020.2020
Shen HH, Alex R, Bellnar L, Raffaele M, Licari M, Vanella L, Stec DE*, Abraham NG. Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity. J. Food Biochem. Oct 12:e13522, 20202020
Hinds TD Jr., Creeden JF, Gordon DM, Spegele A, Britton SL, Koch L, Stec DE. Rats genetically selected for high aerobic exercise capacity have elevated plasma bilirubin by upregulation of hepatic biliverdin reductase-A (BVRA) and suppression of UGT1A1. Antioxidants(Basel) 9:889, 2020.2020
Raffaelle M, Licari M, Amin S, Alex R, Shen HH, Singh SP, Vanella L, Rezzani R, Bonomini F, Peterson SJ, Stec DE, Abraham NG. Cold press pomegranate seed oil attenuates dietary-obesity induced hepatic steatosis and fibrosis through antioxidant and mitochondrial pathways in obese mice. Int. J. Mol. Sci. 21(15):5469, 2020.2020
Gordon DM, Neifer KL, Hamoud AA, Hawk CF, Nestor-Kalinoski AL, Miruzzi SA, Morran M, Adeosun SO, Sarver JG, Erhardt PW, McCullumsmith RE, Stec DE, Hinds TD Jr. Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor α. J. Biol. Chem. 295(29):9804-9822,2020.2020
Shen HH, Peterson SJ, Bellnar L, Choudhary A, Levy L, Gancz L, Sasson A, Trainer J, Rezzani R, Resnick A, Stec DE, Abraham NG. Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection Against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. Antioxidants(Basel) 9(6):489, 2020.2020
Stec DE, Gordon DM, Nestor-Kalinoski AL, Donald MC, Mitchell ZL, Creeden JF, Hinds TD Jr. Biliverdin reductase A (BVRA) knockout in adipocytes induces hypertrophy and reduces mitochondria in white fat of obese mice. Biomolecules, 10(3), 2020.2020
Gordon DM, Adeosun SO, Ngwudike SI, Anderson CD, Hall JE, Hinds TD Jr., Stec DE. CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation. Archives of Biochemistry and Biophysics, 672, 15 September, 2019.2019
Stec DE, Gordon DM, Hipp JA, Hong S, Mitchell ZL, Franco NR, Robison JW, Anderson CD, Stec DF, Hinds TD Jr. The loss of hepatic PPARα promotes inflammation and serum hyperlipidemia in diet-induced obesity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 317(5):R733-R745, 2019.2019
Gordon DM, Blomquist TM, Miruzzi SA, McCullumsmith R, Stec DE, Hinds TD Jr. RNA-sequencing in human HepG2 hepatocytes reveals PPAR mediates transcriptome responsiveness of bilirubin. Physiol Genomics 51(6):234-240, 2019.2019
Peterson SJ, Rubinstein R, Faroqui M, Raza A, Boumaza I, Zhang Y, Stec D, Abraham NG Positive effects of heme oxygenase upregulation on adiposity and vascular dysfunction: Gene targeting vs. Pharmacologic Therapy. Int J Mol Sci. 20(10): 2514-2527, 2019.2019
Bisht K, Canesin G, Cheytan T, Li M, Csizmadia E, Woodruff TM, Stec DE, Bulmer AC, Otterbein LE, Weigel B. Deletion of Biliverdin Reductase A in myeloid cells promotes cytokine expression and chemotaxis in part via a complement C5a-C5aR1 pathway. J Immunol. 202(10):2982-2990, 2019.2019
Stec DF, Henry C, Stec DE, Voziyan P. Changes in urinary metabolome related to body fat involve intermediates of choline processing by gut microbiota. Heliyon 5(4):e01497, 2019.2019
Adeosun SO, Gordon DM, Weeks MF, Moore KH, Hall JE, Hinds TD Jr., Stec DE Loss of biliverdin reductase-A (BVRA) promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells. Am. J. Physiol. Renal Physiol. 315(2):F323-F331, 2018.2018
Bakrania BA, Spradley FT, Satchell SC, Stec DE, Rimoldi JM, Gadepalli RS, Granger JP Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells. Am. J. Physiol. Regul. Integr. Comp. Physiol. 314(3):R427-R43, 2018.2018
Adeosun SO, Moore KH, Lang DM, Nwaneri AC, Hinds TD Jr., Stec DE. A novel fluorescence-based assay for the measurement of biliverdin reductase activity. Reactive Oxygen Species, 5(13):35-45, 2018.2018
George EM, Cockrell K, Arany M, Stec DE, Rimoldi JM, Gadepalli RS, Granger JP Carbon monoxide releasing molecules blunt placental ischemia-induced hypertension. Am. J. Hypertens. 30(9):931-937, 2017.2017
Hosick PA, Weeks MF, Hankins MW, Moore KH, Stec DE. Sex-dependent effects of HO-1 deletion from adipocytes in mice. Int. J. Mol. Sci.18(3)E611, 2017.2017
Hinds TD Jr., Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE Mice with hyperbilirubinemia due to Gilbert’s Syndrome polymorphism are resistant to hepatic steatosis by decreases serine 73 phosphorylation of PPARα Am. J. Physiol. Endocrinol. Metab., 312(4):E244-E252, 2017.2017
Marino JS, Stechschulte LA, Stec DE, Nestor-Kalinoski A, Coleman S, Hinds TD Jr. Glucocorticoid receptor β induces hepatic steatosis by augmenting inflammation and
inhibition of the peroxisome proliferator-activated receptor (PPAR) α J Bio Chem 2016.00-00. Epub Oct 26, 2016.		2016
Hinds TD Jr, Burns KA, Hosick PA, McBeth L, Nestor-Kalinoski A, Drummond HA, AlAmodi AA, Hankins MW, Vanden Heuvel JP, Stec DE Biliverdin reductase A attenuates hepatic steatosis by inhibition of glycogen synthase kinase (GSK) 3β phosphorylation of serine 73 of peroxisome proliferator-activated receptor (PPAR) α. J Biol Chem. 2016 Oct 102016
Ryan MJ, Coleman TT, Sasser JM, Pittman KM, Hankins MW, Stec DE Vascular smooth muscle specific deletion of the leptin receptor attenuates leptin induced vascular relaxation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 310(10):R960-7, 20162016
Stec DE, Juncos LA, Granger JP Renal Intramedullary Infusion of Tempol Normalizes the Blood Pressure Response to Intrarenal Blockade of Heme Oxygenase-1 in Angiotensin II-Dependent Hypertension. J. Am. Soc. Hypertens. 10(4):346-351, 20162016
Stec DE, John K, Trabbic CJ, Luniwal A, Hankins MW, Baum J, Hinds TD Jr Bilirubin binding to PPARalphainhibits lipid accumulation PloS ONE 11(4):e0153427. Doi:10.1371/journal.prone.0153427, 20162016
Lu Y, Wei J, Stec DE, Roman RJ, Ge Y, Cheng L, Liu EY, Zhang Z, Laerkegaard Hansen PB, Fan F, Juncos LA, Wang L, Pollock J, Huang PL, Fu Y, Wang S, Liu R Macula densa nitric oxide synthase 1beta protects against salt-sensitive hypertension J Am Soc Nephrol 27(8):2345-56, 2016.2015
George EM, Stout JM, Stec DE, Granger JP Heme oxygenase induction attenuates TNF-alpha induced hypertension in pregnant rodents. Front. Pharmacol. 6:165 doi: 10.3389/fphar.2015.001652015
Hosick PA, AlAmodi AA, Hankins MW, Stec DE Chronic treatment with a carbon monoxide releasing molecule reverses dietary induced obesity in mice Adipocyte 5:1-10, 20152015
Gannon KP, McKey SE, Stec DE, Drummond HA Altered myogenic vasoconstriction and regulation of whole kidney blood flow in the ASIC2 knockout mouse. Am. J. Physiol. Renal Physiol.308(4), F339-F348, 2015.2015
Hall ME, Maready MW, Hall JE, Stec DE Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation. Am. J. Physiol. Endocrinol. Metab.,307(3),E316-25, 2014.2014
Warrington JP, Coleman K, Skaggs C, Hosick PA, Stec DE, Ryan MJ, Granger JP, Drummond HA. Heme oxygenase-1 promotes migration and beta epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas. Am. J. Physiol. Regul. Integr. Comp. Physiol.306(9),R641-6 2014.2014
Hosick PA, AlAmodi AA, Storm MV, Gousset MU, Pruett BE, Gray III W, Stout J, Stec DE Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet. Int. J. Obesity 38(1):132-139, 20142014
Hosick PA, Ahmed EK, Gousset MU, Granger JP and Stec DE Inhalation of carbon monoxide is ineffective as a long-term therapy to reduce obesity in mice fed a high fat diet BMC Obesity 1:6 20142014
Stout JM, Gousset MU, Drummond HA, Gray III W, Pruett BE, Stec DE Sex-specific effects of heme oxygenase-2 deficiency on renovascular hypertension. J. Am. Soc. Hypertens. 7(5):328-35, 2013.2013
George EM, Hosick PA, Stec DE, Granger JP Heme Oxygenase Inhibition Increases Blood Pressure in Pregnant Rats. Am J Hypertens. 2013 Apr 32013
David E. Stec; Megan V. Storm; Brandon E. Pruett; Monette U. Gousset Antihypertensive Actions of Moderate Hyperbilirubinemia: Role of Superoxide Inhibition American Journal of Hypertension 20132013
Hall ME, Smith G, Hall JE, Stec DE CARDIOMYOCYTE-SPECIFIC DELETION OF LEPTIN RECEPTORS CAUSES LETHAL HEART FAILURE IN CRE-RECOMBINASE MEDIATED CARDIOTOXICITY Am J Physiol Regul Integr Comp Physiol. 2012 303(12):R1241-502012
Chandrashekar K, Lopez-Ruiz A, Juncos R, Nath K, Stec DE, Vera T, Liu R, Juncos LA The modulatory role of heme oxygenase on subpressor angiotensin II-induced hypertension and renal injury. Int. J. Hypertens. 2012;2012:392890.2012
Stec DE, Drummond HA, Gousset MU, Storm MV, Abraham NG, Csongradi E Expression of Heme Oxygenase-1 in Thick Ascending Loop of Henle Attenuates Angiotensin II-Dependent Hypertension. J Am Soc Nephrol. 2012 Feb 9.2012
George EM, Aranay M,Cockrell K, Storm MV, Stec DE, Granger JP Induction of heme oxygenase-1 attenuates sFlt-1 induced hypertension in pregnant rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011 Nov;301(5):R1495-5002011
Csongradi E, Storm MV, Stec DE Renal inhibition of heme oxygenase-1 increases blood pressure in angiotensin-II dependent hypertension Int.J. Hypertens. 2012.2011
Rodriguez F, Lopez B, Perez C, Fenoy FJ, Hernandez I, Stec DE, Li Volti G, Garcia Salom M. Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301(5):R1540-8, 2011.2011
Drummond HA, Grifoni SC, Abu-Zaid A, Gousset M, Chiposi R, Barnard JM, Murphey B, Stec DE Renal inflammation and elevated blood pressure in a mouse model of reduced {beta}ENaC. Am J Physiol Renal Physiol. 20112011 Aug;301(2):F443-9.2011
Hall ME, Smith G, Hall JE, Stec DE Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic mice. Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H253-602011
George EM, Cockrell K,Aranay M, Csongradi E, Stec DE, Granger JP Induction of Heme Oxygenase 1 Attenuates Placental Ischemia-Induced Hypertension. Hypertension. 2011 May;57(5):941-8.2011
Csongradi E, DoCarmo JM, Dubinion JH, Vera T, Stec DE Chronic HO-1 Induction with Cobalt Protoporphyrin (CoPP) Treatment Increases Oxygen Consumption, Activity, Heat Production and Lowers Body Weight in Obese Melanocortin-4 Receptor Deficient Mice International Journal of Obesity.2011.00:002011
Cao J, Sodhi K, Inoue K, Quilley J, Rezzani R, Rodella L, Vanella L, Germinario L, Stec DE, Abraham NG, Kappas A Lentiviral human heme oxygenase targeting endothelium improved vascular function in Ang II model of hypertension. Hum Gene Ther. 22:1-12, 2011.2011
Salahudeen AK, Yang M, Huang H, Dore S, Stec DE Fenoldopam preconditioning: role of heme oxygenase-1 in protecting human tubular cells and rodent kidneys against cold-hypoxia injury. Transplantation. 2011;91(2):176-1822011
Csongradi E, Vera T, Rimoldi JM, Gadepalli RSV, Stec DE In vivo inhibition of renal heme oxygenase with an imidazole-dioxolane inhibitor Pharmacological Research. 2010; 61:525-530.2010
Bardowell SA, Stec DE, Parker RS. Common variants of cytochrome P450 4F2 exhibit altered vitamin E--hydroxylase specific activity Journal of Nutrition.2010;140(11):1901-62010
Vera T and Stec DE. Moderate hyperbilirubinemia improves renal hemodynamics in angiotensin II dependent hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010;299(4):R1044-92010
Stec DE, Vera T, Storm MV, McLemore GR Jr, Ryan MJ. Blood pressure and renal blow flow responses in heme oxygenase-2 knockout mice. Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1822-8.2009
Young SC, Storm MV, Speed JS, Kelsen S, Tiller CV, Vera T, Drummond HA, Stec DE. Inhibition of biliverdin reductase increases ANG II-dependent superoxide levels in cultured renal tubular epithelial cells. Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1546-532009
Vera T, Granger JP, Stec DE Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates Ang II-dependent hypertension in mice Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R738-43.2009
Kelsen S, Patel BJ, Parker LB, Vera T, Rimoldi JM, Gadepalli RS, Drummond HA, Stec DE Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells. Am J Physiol Renal Physiol. 2008 Oct;295(4):F1158-65.2008
Trinity Vera, Silvia Kelsen, David E. Stec Kidney Specific Induction of HO-1 Prevents Angiotensin II Hypertension Hypertension. 2008 October; 52(4): 660–665.2008
Stec DE, Vera T, McLemore GR, Kelsen S, Rimoldi JM, Gadepalli RSV, Ryan MJ Heme oxygenase-1 induction does not improve vascular relaxation in angiotensin II hypertensive mice Am. J. Hypertens. 2008; 21(2):189-93.2008
Zabalgoitia M, Colston JT, Reddy SV, Holt JW, Regan RF, Stec DE, Rimoldi JM, Chandrasekar B Carbon monoxide donors or HO-1 overexpression block interleukin 18 mediated NF-B-PTEN –dependent human cardiac endothelial cell death Free Radical Biology and Medicine. 2008;44:284-298.2008
Stec DE, Roman RJ, Flasch A, Rieder MJ A functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiological Genomics. 2007; 30(1):74-81.2007
Olszanecki R, Rezzani R, Omura S, Stec DE, Rodella L, Botros F, Goodman AI, Drummond G, Abraham NG Genetic suppression of HO-1 exacerbates renal damage: Reversed by an increase in the anti-apoptotic signaling pathway Am. J. Physiol. Renal Physiol. 292:F148-157, 20072007
Stec DE, Gannon KP, Beaird JS, Drummond HA 20-Hydroxyeicosatetraenoic Acid (20-HETE) stimulates migration of vascular smooth muscle cells. Cell Physiol Biochem. 19:121-128, 20072007
Stec DE, Bishop C, Rimoldi JM, Poreddy SR, Vera T, Salahudeen AK Carbon monoxide (CO) protects renal tubular epithelial cells against cold-rewarm apoptosis Renal Failure. 2007; 29:1-6.2007
Vera T, Kelsen S, Yanes LL, Reckelhoff JF, Stec DE HO-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin II hypertensive mice. Am.J. Physiol. Regul. Integr. Comp. Physiol. 2007;292(4): R1472-8.2007
Asija A, Peterson SJ, Stec DE, Abraham NG Targeting endothelial cells with heme oxygenase-1 gene using VE-Cadherin promoter attenuates hyperglycemia-mediated cell injury and apoptosis. Antioxidants & Redox Signaling. 2007; 9(12):2065-73.2007
Goodman AI, Olszanecki R, Yang LM, Quan S, Li M, Omura S, Stec DE, Abraham NG Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins. Kidney Int. 2007; 72(8):945-53.2007
Grifoni SD, Gannon KA, Stec DE, Drummond HA ENaC proteins contribute to VSMC migration. Am. J. Physiol. Heart Circ Physiol. 291(6):H3076-86, 20062006
Ryan MJ, Jernigan NL, Drummond HA, McLemore Jr., GR, Rimoldi JM, Poreddy SR, Gadepalli RSV, Stec DE. Renal vascular responses to CORM-A1 in the mouse Pharmacol Res. 54(1):24-9, 2006.2006
Drummond HA, Furtado MM. Myers S, Grifoni S, Parker KA, Hoover A, Stec DE. ENaC proteins are required for NGF-induced neurite growth. Am. J. Physiol. Cell Physiol.290 (2):C404-C410, 2006.2006
Tallam LS, Stec DE, Willis MA, da Silva AA, Hall JE. Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia. Hypertension 46(2): 326-332, 20052005
Vera T, Taylor M, Bohman Q, Flasch A, Roman RJ, Stec DE Fenofibrate prevents the development of angiotensin II-dependent hypertension in mice. Hypertension 45(2):730-735, 2005.2005
Vera T, Henegar JR, Drummond HA, Rimoldi JM, Stec DE Protective effect of carbon monoxide releasing compounds in ischemia-induced acute renal failure. J Am soc Nephrol 16: 950-958, 2005.2005
Zhu H, Paul IA, Stec DE, Peeler DF, Piletz JE Non-adrenergic exploratory behavior induced by moxonidine at mildy hypotensive doses. Brain Research, 964:9-20, 20032003
Stec DE , Flasch A, Roman RJ, White JA Distribution of Cytochrome P450 4A and 4F isoforms along the nephron in mice. Am. J. Physiol. Renal Physiol., 284:F95-F102, 20032003
Badmus OO, Kipp ZA, Bates EA, da Silva AA, Taylor LC, Martinez GJ, Lee WH, Creeden JF, Hinds TD Jr, Stec DE. Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease. Am J Physiol Regul Integr Comp Physiol. 2023 Jul 1;325(1):R81-R95. doi: 10.1152/ajpregu.00057.2023.2023

Review Article

Badmus OO, Hinds TD Jr, Stec DE. Mechanisms Linking Metabolic-Associated Fatty Liver Disease (MAFLD) to Cardiovascular Disease Curr Hypertens Rep. 2023 Aug;25(8):151-162. doi: 10.1007/s11906-023-01242-8.2023
Vitek L, Hinds TD Jr., Stec DE, Tiribelli C. The Physiology of Bilirubin: Health and Disease Equilibrium. Trends in Molecular Medicine 29(4):315,328, 20232023
Flack KD, Vitek L, Fry C, Stec DE, Hinds TD Jr. Cutting edge concepts: Does bilirubin enhance exercise performance? Frontiers in Sports and Active Living, section Elite Sports and Performance Enhancement Jan 11;4:1040687, 2023.2023
Badmus OO, Hillhouse SA, Anderson CD, Hinds TD Jr, Stec DE. Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways. Clin Sci (London) 136(18) 1347-1366, 2022.2022
Stec DE, Tiribelli C, Badmus OO, Hinds TD Jr. Novel function for bilirubin as a metabolic signaling molecule: Implications for kidney diseases. Kidney360 3(5):945-953, 2022.2022
Thomas DT, DelCimmuto NR, Flack KD, Stec DE, Hinds TD Jr. Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin. Antioxidants(Basel)11:179, 20222022
McClung JA, Levy L, Garcia V, Stec DE, Peterson SJ, Abraham NG. Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications Pharmacol Ther. 2021 Sep 6:1079752021
Hinds TD Jr., and Stec DE. Natural product HO-1 inducers as treatment for nonalcoholic fatty liver disease. Int. J. Mol. Sci. 21(24) 9493, 2020.2020
Creeden JF, Gordon DM, Stec DE, Hinds TD Jr. Bilirubin as a Metabolic Hormone: The Physiological Relevance of Low Levels. Am. J. Physiol. Endocrinol. Metab., 320(2)E191,E207, 2021.2020
Hinds TD Jr., Stec DE. Bilirubin safeguards cardiorenal and metabolic diseases: A protective role in health. Curr Hypertens Rep. 21(11), 2019.2019
Drummond HA, Mitchell ZL, Abraham NG, Stec DE. Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease. Antioxidants(Basel) 8(6):181, 2019.2019
Hinds TD Jr., Stec DE. Bilirubin, a Cardiometabolic Signaling Molecule. Hypertension. 72(4):788-795, 2018.2018
Sundararaghavan VL, Binepal S, Stec DE, Sindhwani P, Hinds TD Jr. Bilirubin, a new therapeutic for kidney transplant? Transplant Rev (Orlando). 32(4):234-240, 2018.2018
Hamoud AR, Weaver L, Stec DE, Hinds TD Jr. Bilirubin in the liver-gut signaling axis. Trends in Endocrinology and Metabolism. 29(3):140-150,2018.2018
Weaver L, Hamoud AA, Stec DE, Hinds TD Jr. Biliverdin Reductase and Bilirubin in Hepatic Disease. Am. J. Physiol. Gastrointest Liver Physiol. 314(6):G668-G676, 2018.2018
Hinds TD Jr., Adeosun SO, Alamodi AA, Stec DE Does bilirubin prevent hepatic steatosis through activation of the PPARalpha nuclear receptor? Medical Hypotheses. 95:54-57, 20162016
Hall ME, Harmancey R, Stec DE Lean heart: Role of leptin in cardiac hypertrophy and metabolism. World Journal of Cardiology 7(9):511-524, 20152015
Drummond HA and Stec DE. betaENaC acts as a mechanosensor in renal vascular smooth muscle cells that contributes to renal myogenic blood flow regulation, protection from renal injury and hypertension. J. of Nephrology Res 1(1):1-9, 20152015
O’Brien L, Hosick PA, John K, Stec DE, Hind Jr., TD Biliverdin reductase isozymes in metabolism. Trends in Endocrinology and Metabolism. 26(4):212-220, 20152015
Csongradi E, Juncos LA, Drummond HA, Vera T, Stec DE Role of Carbon Monoxide in Kidney Function: Is a little Carbon Monoxide Good for the Kidney? Curr Pharm Biotechnol. 2012 Sep 12012
Stec DE, Drummond HA, Vera T Role of Carbon Monoxide in Blood Pressure Regulation Hypertension. 2008; 51:1-8.2012
Stec DE, Hosick PA, Granger JP Bilirubin, Renal Hemodynamics, and Blood Pressure Front Pharmacol. 2012;3:18. Epub 2012 Feb 142012
Hosick PA and Stec DE Heme oxygenase, a novel target for the treatment of hypertension and obesity? Am J Physiol Regul Integr Comp Physiol. 2012 Jan;302(2):R207-14.2012
Hall JE, da Silva AA, do Carmo JM, Dubinion J, Hamza S, Munusamy S, Smith G, Stec DE Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. Journal of Biological Chemistry. 2010;285(23):17271-6.2010
Vera T and Stec DE Heme Oxygenase-1: A potential anti-hypertensive target. Current Hypertension Reviews. 3(1): 75-82, 20072007
Granger JP, Abram S, Stec DE, Chandler D, LaMarca B Endothelin, the Kidney,and Hypertension. Current Hypertension Reports. 8(4): 298-303, 2006.2006

Book Chapter

Hong S, Gordon DM, Stec DE, and Hinds TD, Jr. Bilirubin: A Ligand of the PPARα Nuclear Receptor. Nuclear Receptors: The Art and Science of Modulator Design and Discovery. Springer Nature, Basingstoke, United Kingdom, 2020.2020

Book

Stec DE Heme Oxygenase and the Kidney Morgan Claypool, San Francisco, 20112011

Editorial Commentary

Piñeiro-Llanes J, Stec DE, Cristofoletti R. Editorial: Insights in drug metabolism and transport: 2021. Front Pharmacol. 2023 May 9;14:1198598. doi: 10.3389/fphar.2023.1198598.2023
Hinds TD Jr, Stec DE, Tiribelli C. Powering the Powerhouse: Heme oxygenase-1 regulates mitochondrial function in non-alcoholic fatty liver disease (NAFLD). Acta Physiol (Oxf) 237(3):e13931, 2023.2023
Stec DE, Weigel B, Hinds TD Jr. Editorial: Oxidative stress, antioxidants, transcription factors, and assimilation of signal transduction pathways in obesity-related disorders. Frontiers in Pharmacology. 12:759468. doi: 10.3389/fphar.2021.759468, 2021.2021
Stec DE and Abraham NG Pharmacological and Clinical Significance of Heme Oxygenase-1 Antioxidants(Basel) 10(6):854, 2021.2021
Surh YJ, Chung HT, Na HK, Dulak J, Stec DE. Progress in heme oxygenase research. Archives of Biochemistry and Biophysics, 685:108321, May 30, 2020.2020
Adeosun SO and Stec DE. Bilirubin protects the ageing heart. Acta Physiol (Oxf), 220(4):402-403, 2017.2017
Stec DE, Ishikawa K, Sacerdoti D, Abraham NG. The emerging role of heme oxygenase and its metabolites in the regulation of cardiovascular function. Int J Hypertens. 2012;2012:5935302012
Stec DE Smart Gene Therapy for the Heart. Hypertension 43:720-721, 20042004

Presentations

State/Local Invited Seminars/Lectures, Cardiovascular Disease in NAFLD: Unraveling Mechanisms, UMMC12/2021
National and International Invited Seminars/Lectures, Nuclear Receptors and Metabolism, American Physiological Society, Virtual04/2021
State/Local Invited Seminars/Lectures, Mechanistic Insights of Bilirubin/Biliverdin Reductase Protection in NAFLD, Department of Physiology & Biophysics, UMMC, Jackson, MS12/2020
National and International Invited Seminars/Lectures, Heme Oxygenase and Related Enzymes: From Physiology to Therapeutics, International Congress on Heme Oxygenases and Related Enzymes, Los Angeles06/2020
Regional Invited Seminars/Lectures, Role of Bilirubin and Biliverdin Reductase in Metabolic Disease, New York Medical College, Vahalla, NY05/2019
State/Local Invited Seminars/Lectures, Is Serum Bilirubin the Key to Cardiovascular and Metabolic Health?, Department of Physiology & Biophysics, UMMC, Jackson, MS03/2019
National and International Invited Seminars/Lectures, Loss of biliverdin reductase-A (BVRA) promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells, 10th International Conference on Heme Oxygenase 2018, Seoul, South Korea11/2018
Regional Invited Seminars/Lectures, Role of Biliverdin Reductase-A (BVRA) in Renal Injury, Tulane University School of Medicine, New Orleans, LA10/2018
Regional Invited Seminars/Lectures, Role of Bilirubin and Biliverdin Reductase in Metabolic Disease., Tulane University School of Medicine, New Orleans, LA10/2018
State/Local Invited Seminars/Lectures, Bilirubin and Biliverdin Reductase in Metabolic Disease, Department of Physiology and Biophyiscs, UMMC, Jackson, MS03/2018
National and International Invited Seminars/Lectures, Carbon Monoxide-Releasing Molecules (CORMs) as Novel Anti-Obesity Drugs, 1st American Gasotransmitter Symposium, Atlanta, GA04/2017
Invited Symposia, Carbon Monoxide-Releasing Molecules (CORMs) as Novel Anti-Obesity Drugs, Preconditioning in Biology and Medicine, Amherst, MA04/2017
National and International Invited Seminars/Lectures, Role of Heme Oxygenase-2 in Arterial Hypertension, 9th International Congress on Heme Oxygenases and Related Enzymes, Prague, Czech Republic09/2016
National and International Invited Seminars/Lectures, Role of Biliverdin Reducatase A in Hepatic Steatosis, 9th International Congress on Heme Oxygenases and Related Enzymes, Prague, Czech Republic09/2016
State/Local Invited Seminars/Lectures, Carbon Monoxide Donors as Novel Anti-Obesity Drugs, Medical Scientist Research Program, 7A, UMMC07/2016
State/Local Invited Seminars/Lectures, Role of Bilirubin/Biliverdin Reductase in Hepatic Steatosis, Medical Student Research Program, 7A, UMMC06/2016
State/Local Invited Seminars/Lectures, Bilirubin and Biliverdin Reductase in Metabolic Disease, Department of Physiology & Biophysics, UMMC, CW30803/2016
State/Local Invited Seminars/Lectures, Bilirubin and Metabolic Disease: Novel Protective Pathway, Department of Physiology & Biophysics, CW308, UMMC07/2015
State/Local Invited Seminars/Lectures, Carbon Monoxide: Silent Killer of Obesity and Diabetes??, Department of Physiology & Biophysics, CW308, UMMC07/2014
National and International Invited Seminars/Lectures, Role of Heme Oxygenase Metabolites in Obesity, Department of Pharmacology & Physiology, University of Toledo Health Sciences Center, Toledo, Ohio05/2014
State/Local Invited Seminars/Lectures, Bilirubin: Target for the Treatment of Hypertension and Metabolic Syndrome?, Department of Physiology & Biophysics, CW308,UMMC07/2013
National and International Invited Seminars/Lectures, Renal Heme Oxygenase and its metabolites in the regulation of blood pressure, Renal Hemodynamics:Integrating with the nephron and Beyond, Saxtons River, Vermont07/2013
National and International Invited Seminars/Lectures, Emerging role of heme oxygenase in the regulation of body weight and metabolism, 7th International Congress on Heme Oxygenases and Related Enzymes, Edinburgh, Scotland06/2012
National and International Invited Seminars/Lectures, Bioenergetic and Metabolic Disorders, 7th International Congress on Heme Oxygenases and Related Enzymes, Edinburgh, Scotland06/2012
National and International Invited Seminars/Lectures, Heme oxygenase and blood pressure regulation., ASPET Symposium/Experimental Biology 2012, San Diego, California04/2012
National and International Invited Seminars/Lectures, The role of heme oxygenase and its metabolites in the regulation of blood pressure, Department of Physiology & Pharmacology, the University of Toledo College of Medicine, Toledo, Ohio02/2011
Poster Presentation, Heme Oxygenase (HO) Activity Modulates Subpressor Angiotensin II (SP-AngII)-induced Hypertension (HTN) and Renal Injury, American Soceity of Nephrology Renal Week, Denver, Colorado11/2010
Poster Presentation, Effect of chronic cobalt protoporphyrin (CoPP) treatment on body weight and metabolism in melanocortin-4-receptor knockout mice., Global Obesity Summit, Jackson, Mississippi11/2010
Poster Presentation, Rescue of the cardiac leptin receptor in db/db mice prevents cardiac lipid accumulation and subsequent diastoic dysfunction, Global Obesity Summit, Jackson, Mississippi11/2010
Scientific Presentations, Thick Ascending Loop of Henle (TALH) Specific Expression of HO-1 Attenuates the Development of AngII-dependent Hypertension, American Heart Association Council for High Blood Pressure Research, Washington, D.C.10/2010
Poster Presentation, In vivo Inhibition of Renal Heme Oxygenase-1 with an Imidazole-Dioxolane Inhibitor, QC-13., Experimental Biology 2010, Anaheim, California04/2010
Invited Symposia, Moderate Hyperbilirubinemia Improves Renal Hemodynamics in Angiotensin II-Dependent Hypertension., Experimental Biology 2010, Anahein, California04/2010
State/Local Invited Seminars/Lectures, Renal Heme Oxygenase and Hypertension, Division of Nephrology, University of Alabama-Birmingham Health Science Center, University of Alabama-Birmingham, Birmingham, Alabama03/2010
State/Local Invited Seminars/Lectures, Renal Heme Oxygenase and Hypertension, Department of Pharmacology & Toxicology, Virginia Commonwealth University, Virginia Commonwealth University, Richmond, Virginia03/2010
Poster Presentation, DETERMINATION OF DISEASE BIOMARKERS FROM MOUSE AND HUMAN, 38th Southeastern Magnetic Resonance Conference /Vanderbilt University, Nashville, TN11/2009
National and International Invited Seminars/Lectures, Development of a Transgenic Mouse Model Expressing Heme Oxgenase-1 in Renal Thick Ascending Loop of Henle Cells in vivo., Heme Oxygenases in Biology & Medicine, 6th International Congress, Miami, FL10/2009
National and International Invited Seminars/Lectures, Renal heme oxygenase and hypertension, American Society of Hypertension (ASH) 24th Annual Scientific Meeting and Exposition, San Francisco, CA05/2009
Poster Presentation, Rescue of cardiac leptin receptor improves diastolic function and prevents cardiac lipid accumulation in db/db mice., Experimental Biology 2009, New Orleans, LA04/2009
Poster Presentation, Inhibition of bilirubin metabolism attenuates angiotensin-II dependent hypertension in mice, Experimental Biology 2008/American Physiological Society, San Francisco, California04/2008
Poster Presentation, Inhibition of biliverdin reductase increases angiotensin II-mediated superoxide production in thick ascending loop of Henle cells, Experimental Biology 2008, San Francisco, California04/2008
Poster Presentation, 20-HETE contributes to hypertension in postmenopausal rats, Experimental Biology 2008/American Physiological Society, San Francisco, California04/2008
Poster Presentation, Rapid cardiac dysfunction caused by inducible cardiac-specific leptin receptor deletion., Experimental Biology 2008/American Physiological Society, San Francisco, California04/2008

Honors, Awards, and Recognition

Platinum Level for the Excellence in Research Award, University of Mississippi Medical Center2023
Chair, Hypertension Peer Review Fellowship Committee, American Heart Association2021
Co-Organizer, Heme Oxygenase and Related Enzymes: From Physiology to Therapeutics, American Physiological Society2020
Intellectual Property Recognition Award, University of Mississippi Medical Center2019
Peter Hosick-Postdoctoral Fellow Publication Award, School of Graduate Studies, University of Mississippi Medical Center2014
Peter Hosick-Caroline tum Suden/Francis Hellebrandt Professional Opportunity Award, American Physiological Society2013
Matthew Maready-Caroline tum Suden/Francis Hellebrandt Professional Opportunity Award, American Physiological Society2009
Trinity Vera-American Physiological Society-Water and Electrolyte Homeostasis Section Travel Award, American Physiological Society2007
Trinity Vera-Caroline tum Suden/Francis Hellebrandt Professional Opportunity Award, American Physiological Society2007
Gold Level for the Excellence in Research Award, University of Mississippi Medical Center
2009 Young Investigator Award, American Society of Hypertension

Professional Membership and Service

American Heart Association, Fellow, Council for High Blood Pressure Research2003 - Present
American Society of Biochemistry and Molecular Biology, Member2001 - Present
American Physiological Society, Member1992 - Present

Committee Service

AHA Transformational Project Award Vascular 1, Co-Chair2022 - 2022
Pathophysiology of Obesity and Metabolic Disease (POMD) Study Section, Member2021 - 2021
National Institutes of Health-The Hemostasis, Thrombosis, Blood Cells and Transfusion Medicine (HTBT) Study Section, ZRG1 VH-D02 Special Emphasis Panel, Member2021 - 2021
Department of Physiology and Biophysics Tenure and Promotion Committee, Member2019 - Present
Department of Physiology and Biophysics Curriculum Committee, Member2015 - Present
University of Mississippi Medical Center, Office of Research, Intramural Grant Review Committee, Member2015 - Present
Department of Physiology & Biophysics Faculty Recruitment Committee, Member2014 - Present
School of Graduate Studies in Health Sciences- Nelson Order Selection Committee, Member2014 - Present
American Physiological Society, Perkins Award Committee, Member2009 - 2011
MEDICAL CENTER-ANIMAL CARE AND USE, Member2005 - 2010
American Physiological Society, Membership Committee, Member2005 - 2008

Other Service

Multi-COBRE Seminar Series04/2023 - Present
Scientific Reports10/2016 - Present
Molecules10/2016 - Present
Center for Scientific Review Special Emphasis Panel06/2016 - 06/2016
Integrative Obesity and Diabetes Journal04/2016 - Present
Nitric Oxide: Biology & Chemistry04/2016 - Present
Kidney and Blood Pressure Research03/2016 - Present
Oncotarget03/2016 - Present
National Science Center, Poland02/2016 - 03/2016
International Journal of Molecular Science08/2015 - Present
Frontiers in Pharmacology-Drug Metabolism and Transport06/2015 - Present
Plos One03/2015 - Present
Life Sciences2015 - Present
American Heart Association, Collaborative Science Grant Proposal Initial Review Committee10/2014 - Present
Journal of the American Society of Hypertension06/2014 - Present
Obesity02/2014 - Present
American Heart Association- Council for High Blood Pressure Research Meeting Abstract Reviewer03/2013 - Present
American Journal of Hypertension09/2012 - Present
Experimental Physiology02/2012 - Present
Prostaglandins and Other Lipid Mediators2012 - Present
American Heart Association, National Cardiorenal 1 Study Section, Study Section Chair2012 - 12/2014
Molecular Vision03/2011 - Present
International Journal of Hypertension03/2011 - 2012
NHLBI Systems Biology Grant Peer Review Study Section12/2010 - 01/2011
Italian Ministry of Health09/2010 - 03/2011
Nephrology, Dialysis, and Transplantation08/2010 - Present
Kidney International07/2010 - Present
Journal of Cellular Biochemistry07/2010 - Present
Cellular and Molecular Biology07/2010 - Present
BMC-Cancer07/2010 - Present
Physiological Genomics06/2010 - Present
American Heart Association, National Cardiorenal 1 Study Section, Co-Chair2010 - 12/2011
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology2009 - Present
Journal of the American Society of Nephrology06/2006 - Present
Open Biochemistry Journal2006 - Present
Current Hypertension Reviews2005 - Present
Hypertension2003 - Present
American Journal of Physiology-Heart and Circulatory Physiology07/2001 - Present
American Journal of Physiology-Renal Physiology07/2001 - Present
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology07/2001 - Present
Hypertension06/2001 - Present

Teaching Experience

PHYSIO 731, Graduate, Course, Course Director, Renal and Body Fluid Physiology.Spring 2023 - 2023
PHYSIO 717, Graduate, Course, Lecturer, Circulatory Physiology.Fall 2022 - 2022
Dent625-Phys725, Graduate, Course, Lecturer, Fundamentals of PhysiologyFall 2022 - 2022
PHYSIO 727, Graduate, Course, Course Director, Physiological Applications of Molecular Biology.Fall 2022 - 2023
PHYSIO 725, Graduate, Course, Lecturer, Dental/Fundamental PhysiologyFall 2020 - 2020
PHYSIO 731, Graduate, Course, Course Director, Renal and Body Fluid PhysiologySpring 2019 - 2019
PHYSIO 725, Graduate, Course, Lecturer, Dental/Fundamental PhysiologyFall 2019 - 2019
PHYSIO 727, Graduate, Course, Course Director, Physiological Applications of Molecular BiologyFall 2019 - 2019
PHYSIO 725, Graduate, Course, Lecturer, Dental/Fundamental PhysiologySpring 2018 - 2018
PHYSIO 731, Graduate, Course, Course Director, Renal and Body Fluid PhysiologySpring 2018 - 2018
PHYSIO 727, Graduate, Course, Course Director, Physiological Applications of Molecular BiologyFall 2018 - 2018
PHYSIO 717, Graduate, Course, Lecturer, Circulatory PhysiologyFall 2018 - 2018
PHYSIO 715, Graduate, Course, Lecturer, EndocrinologyFall 2018 - 2018
PHYSIO 725, Graduate, Lecture, Lecturer, Dental/Fundamental PhysiologySpring 2017
PHYSIO 731, Graduate, Course, Course Director, Renal and Body Fluid PhysiologySpring 2017 - 2017
PHYSIO 727, Graduate, Course, Course Director, Physiological Applications of Molecular BiologyFall 2017 - 2017
PHYSIO 717, Graduate, Lecture, Lecturer, Circulatory PhysiologyFall 2017 - 2017
PHYSIO 731, Medicine, Course, Course Director, Renal and Body Fluid PhysiologySpring 2016 - 2016
PHYSIO 727, Medicine, Course, Course Director, Physiological Applications of Molecular BiologySpring 2016 - 2016
PHYSIO 731, Medicine, Course, Lecturer, Renal and Body Fluid PhysiologySpring 2016 - 2017
PHYSIO 727, Medicine, Course, Lecturer, Physiological Application of Molecular BiologySpring 2016 - 2106
PHYSIO 701, Medicine, Small Group, Facilitator, Medical PhysiologySpring 2016 - 2016
PHYSIO 717, Medicine, Lecture, Lecturer, Circulatory PhysiologyFall 2015 - 2015
727, Graduate, Course, Lecturer, Current Issues in Biomedical Research and Translational MedicineSpring 2011
710, Graduate, Course, Lecturer, Research Tools in Molecular BiologySpring 2011
725, Dentistry, Course, Lecturer, Dental PhysiologyFall 2010
725, Dentistry, Course, Course Presenter, Dental PhysiologyFall 2009
7004, Graduate, Course, Course Director, Molecular PhysiololgySpring 2008
Graduate, Small Group, Course Presenter, Real Time PCR for Pathology ResidentsFall 2007
Graduate, Lecture, Guest Presenter, Cardiovascular PhysiologySpring

Directed Student Learning

Preceptor, Advised: Stephan Holt2020 - 2021
Preceptor, Advised: Nicholas Childers2020 - 2021
Preceptor, Advised: Luke Wooten2020 - 2021
Preceptor, Advised: Benjamin Hubbard2020 - 2021
Preceptor, Advised: Katelyn Childers2020 - 2021
Preceptor, Advised: Scott Murphy2020 - 2021
Dissertation Committee Member, Endothelin-1 in Obesity-induced Insulin Resistance
Advised: Osvaldo Rivera-Gonzalez		2019 - 2021
Dissertation Committee Member, Impact of UCP3 Deficiency on High Fat diet-Induced Obesity and Insulin Resistance
2018 - 2020
Dissertation Committee Member, The Role of Autoimmunity in Progression of Renal Injury in a Murine Model of Systemic Lupus Erythematosus
Advised: Elena Dent		2018 - 2020
Dissertation Committee Member, Ovarian Hormones and Hypertension in Systemic Lupus Erythematosus
Advised: Victoria Wolfe		2016 - 2018
Internship Advisor, Advised: Alexander Griggs2016 - 2016
Research Advisor, Advised: Mary Francis Weeks2016 - 2016
Preceptor, Advised: Joanna Boyles2015 - Present
Preceptor, Advised: Peyton Reves2015 - Present
Research Advisor, Advised: Jacob Stout2015 - Present
Research Advisor, Advised: Abdulhadi Alamodi2015 - Present
Preceptor, Advised: Erin Smith2014 - 2016
Preceptor, Advised: Oliver Liu2014 - 2016
Preceptor, Advised: Mark Ward2014 - 2016

Fellows supervised

Physiology & Biophysics, Post-Doc Advisor, 1 fellows supervised09/2023 - Present
Physiology & Biophysics, Training Faculty, 1 fellows supervised01/2023 - Present
Physiology & Biophysics, Post-Doc Advisor, 1 fellows supervised10/2021 - 01/2023
Physiology & Biophysics, Research Advisor, 1 fellows supervised04/2016 - Present
Physiology & Biophyscis, Research Advisor, 1 fellows supervised, Peter A. Hosick08/2011 - 08/2014
Physiology & Biophysics, Training Faculty, 1 fellows supervised, Eva Csongradi06/2010 - 03/2011
Physiology & Biophysics, Training Faculty, 1 fellows supervised, Instructor/Trinity Vera07/2007 - 06/2008