Jawed A. Siddiqui, PhD
Assistant Professor
Department:
SOM-Cell and Molecular Biology
Email:
jsiddiqui@umc.edu
Work Phone:
(601) 984-4309
Biography
One of the major objectives of our laboratory is to elucidate the biological mechanisms underlying bone metastasis of different malignancies. Bone metastases or dissemination of cancer cells within the bone are considered an advanced, debilitating, and incurable disease. Despite its high morbidity and mortality, the biology of bone metastasis signifies one of the most multifaceted and fascinating processes in several malignancies. Prostate, breast, lung, and kidney cancers have characteristics of selective bone tropism.
Our lab has developed unique techniques and experimental models that allow us to decipher bone metastasis. We are interested in dissecting how metastatic cancers evolve to persuade the immune system's dysfunctionality in primary and metastatic sites among tumors of diverse genetic backgrounds. We study how cancer cells influence bone resident macrophages (Osteomacs) for their colonization and growth within the bone microenvironment and design therapeutic strategies accordingly.
Current projects in the lab include:
1. Molecular mechanism of bone metastasis (Prostate, Breast, and Lung cancer)
2. Bone Microenvironment
3. Osteoimmunology and Tumor Dormancy.
4. Development of the Bone Metastasis Therapeutics
Research Opportunities:
We always look for highly enthusiastic researchers to join as graduate students, summer fellows, clinical fellows, and postdoctoral fellows. We are continuously open to collaboration.
Education
| Central Drug Research Institute/JNU, India, PhD, Endocrinology and Bone Biology | 2012 |
| Calicut University, Kerala, India, MS, Biotechnology | 2006 |
Specialty Certification Licensure
| Certification, Facilitating Entering Mentoring by CIMER @ UNMC | 10/2023 - Present |
Current Positions
| Assistant Professor, School of Medicine, Department of Cell and Molecular Biology | 08/2024 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Nebraska Medical Center, School of Medicine | 06/2021 - 08/2024 |
| Instructor, University of Nebraska Medical Center, School of Medicine | 10/2018 - 05/2021 |
Presentations
| National and International Invited Seminars/Lectures, Growth Factors Driving Bone Niche Formation in Prostate Cancer, Prostate Cancer Center of Excellence at Mount Sinai, New York, Mount Sinai, New York | 05/2025 |
| National and International Invited Seminars/Lectures, Growth factors from Biomarker to therapy of prostate cancer, University of Chicago, Rockford, University of Chicago, Rockford | 02/2025 |
| State/Local Invited Seminars/Lectures, From Biomarker to Therapeutic Target: GDF15 in Prostate Cancer Bone Metastasis, VA NWIHCS Friday Research Seminar, Omaha, Nebraska | 2024 |
| National and International Invited Seminars/Lectures, Growth Factors in Prostate Cancer Bone Metastasis, MSK research discovery meeting. Orthopaedic Surgery Department, UNMC, Omaha, NE | 06/2023 |
| National and International Invited Seminars/Lectures, Growth Factors and Chemokines in Niche Formation Bone Metastasis, University of North Carolina, Chapel Hill, UNC, Chapel Hill | 05/2023 |
| National and International Invited Seminars/Lectures, Multifaceted role of Chemokines and Growth Factors in Niche Formation and Bone Metastasis., Center for Research in Anabolic Skeletal Targets in Health and Illness, Lucknow, India | 06/2022 |
| Poster Presentation, I have presented scientific posters at several national and international conferences, including the American Association for Cancer Research (AACR) Annual Meeting and various regional conferences. Number of posters # 9 (AACR=5, and Other national and regional conferences (4))., AACR, Midwest, MAS and UNMC conference | 05/2021 |
| State/Local Invited Seminars/Lectures, Pathophysiological Role of Macrophage Inhibitory Cytokine-1 (MIC-1) in Prostate Cancer-Bone Metastasis at, GU Oncology Focus Group, Omaha | 05/2017 |
| National and International Invited Seminars/Lectures, Monocyte Chemoattractant Protein (MCP-1) regulates the Bone anabolic effect of the Parathyroid hormone., IUPUI, Indianapolis | 11/2015 |
| National and International Invited Seminars/Lectures, Catabolic Effect of Parathyroid Hormone on Bone: Role of Monocyte Chemoattractant Protein., Rush Medical College, Chicago, IL | 10/2015 |
| Invited Symposia, The bone anabolic effect of parathyroid hormone via Monocyte Chemoattractant Protein, British Bone Research meeting, Edinburg, Scotland | 08/2015 |
Honors, Awards, and Recognition
| TREC Fellow, Transdisciplinary Research Education Program in Energetics and Cancer | 2025 |
| Young Investigator Award, Society for Basic Urologic Research (SBUR), USA | 2024 |
| New Investigator Award, University of Nebraska Medical Center, Omaha | 2023 |
| Young Investigator Award, American Association of Indian Scientists in Cancer Research (AAISCR), USA | 2021 |
| Outstanding performance award, University of Nebraska Medical Center, Omaha, NE | 2018 |
| Alice L. Jee Young Investigator Award, Orthopedic Research Society, USA | 2015 |
| Young Investigator Grant, British Bone Research and ASBMR, UK | 2015 |
| Best Oral presentation, British Bone Research meeting, Edinburg, Scotland | 2015 |
| Eight Fellows Forum on Metabolic Bone Diseases, Endocrine Fellows Foundation , USA | 2014 |
| Young Investigator Travel Grant, The American Society of Bone and Mineral Research, USA | 2014 |
| Recognized among the Top 10 Researchers in India in the field of Osteoporosis, Annals of Library and Information Studies | 2013 |
| Senior Research Fellowship, University Grant Commission (UGC), India | 2008 |
| Junior Research Fellowship, University Grant Commission (UGC), India | 2006 |
Professional Membership and Service
| Cancer Center Research Institute (CCRI), Member | 2024 - Present |
| American Society of Bone and Mineral research, Member | 2015 - Present |
Committee Service
| Coordinator of GU Cancer Focus Group, University of Mississippi Medical center, Coordinator | 2025 - Present |
| Postdoc Mentoring Committee, UNMC, Member | 2023 - 2024 |
| UNMC-BMB Annual Symposium, Task Force Member | 2022 - 2024 |
| Master’s Student Committee, UNMC-BMB, Member | 2022 - 2024 |
| Annual Biomedical Research Conference for Minority Students, Task Force Member | 2016 - 2017 |
Other Service
| Prostate Cancer Research Foundation UK | 08/2025 - Present |
| Nature-Springer Cellular Oncology on research Topic “Tumor Microenvironment and Metastasis | 02/2025 - Present |
| GU Cancer Focus Group, University of Mississippi Medical center | 2025 - Present |
| NJDOH Cancer Program, New Jersey | 03/2024 - Present |
| Qatar Foundation Study section | 2023 - Present |
| Seminars in cancer biology editing the special issue ‘Chemokines’ | 05/2021 - 04/2022 |
| Annual Biomedical Research Conference for Minority Students (ABRCMS | 05/2017 - 08/2018 |
Teaching Experience
| SOM615, Medicine, Lecture, Lecturer, Cancers of the Renal & Genitourinary Systems | Summer 2025 |
| CMB740, Graduate, Lab, Instructor, Cell and Molecular Biology Methods | Annual 2025 |
Directed Student Learning
| INBRE UNMC, Advised: Vivian Moultrie | 2016 - 2016 |