James K. Rowlett, PhD

James K. Rowlett, PhD

Professor

Department:
SOM-Psychiatry

Email:
jrowlett@umc.edu

Work Phone:
(601) 984-4488

Education

University of Kentucky, PhD, Experimental Psychology1993
University of Kentucky, MS, Experimental Psychology1991
Morehead State University, BA, Psychology1988

Current Positions

Vice Chair for Research-Department of Psychiatry & Human Behavior, Department of Psychiatry04/2017 - Present
Professor (adjunct)-Department of Neurobiology & Anatomical Sciences, Department of Neurobiology and Anatomical Sciences2015 - Present
Core Scientist-Tulane National Primate Research Center2014 - Present
Professor, School of Medicine, Department of Psychiatry08/2013 - Present
Director of Mentoring, Center for Psychiatric Neuroscience, School of Medicine, Department of Psychiatry08/2013 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Co-Director, Laboratory of Behavioral Biology, New England Primate Research Center, School of Medicine, Department of Division of Neuroscience2008 - 08/2013
Associate Professor, Harvard Medical School/Beth Israel Deaconess Medical Center, School of Medicine, Department of Psychiatry2007 - 08/2013
Member, Center for Neurodegeneration and Repair, Harvard Medical School, School of Medicine2004 - 08/2013
Consultant, Merck Research Laboratories, Department of Laboratory2002 - 2004
Associate scientist, Neuroscience and Behavior Program, University of Massachusetts, Amherst, School of Medicine, Department of Psychiatry2001 - 08/2013
Assistant Professor, Harvard Medical School/Beth Israel Deaconess Medical Center, School of Medicine, Department of Psychiatry1999 - 2007
Supervisor, Behavioral Pharmacology Laboratory, New England Regional Primate Reseasrch Center, School of Medicine, Department of Psychiatry1999 - 2007
Instructor, Harvard Medical School, School of Medicine, Department of Psychiatry1997 - 1999
Senior Research Associate, University of Mississippi Medical Center, School of Medicine, Department of Behavioral Pharmacology/Neuropharmacology1993 - 1997
Research Assistant, University of Kentucky1989 - 12/1989
Research Assistant, Morehead State University, School of Medicine1986 - 1988
Core Scientist and Chief, Behavioral Pharmacology Unit, New England Regional Primate Research Center, School of Medicine, Department of Psychiatry1997 - 1999

Sponsored Program Funding

Extramural, Tolerance and Physical Dependence after Chronic Benzodiazepine Treatment, NIDA/R01 DA043204-01A101/2017 - 01/2022
Extramural, Unpredictable drug and non-drug alternatives as determinants of cocaine choice, NIDA/1F32 DA037619-0101/2014 - 01/2017
Extramural, Center for Psychiatric Neuroscience, NIGMS/1P30 GM103328-0101/2013 - 01/2018
Extramural, Neurosteroid-BZ Combinations: Strategy for reducing abuse and sedation, NIDA/1R01 DA033795-0201/2012 - 01/2017
Extramural, GDNF for Parkinson's Disease: Next Steps in Preclinical Development, Michael J. Fox Foundation for Parkinson's Research01/2011 - 01/2012
Extramural, Efficacy of GABAA alpha 5 receptor inverse agonists in learning impaired rats, NIMH/1R43 MH085378-0101/2011 - 12/2011
Extramural, Novel GABA-A Modulators as Cognitive Enhancers, NIA/R01 AG035361-0501/2010 - 01/2016
Extramural, A Metabolic Model of Aging in the Common Marmoset, NIA/1R01 AG038746-0301/2010 - 01/2015
Extramural, Effects of test Compound (RO) in the Object Retrieval with Detours Task in Monkeys, F. Hoffman-La Roche Ltd A13461 (Research Contract)01/2010 - 01/2011
Extramural, New England Primate Research Centr Base Grant: NCRR ARRA Supplement-Translational, NCRR/P51 RR00168-48S201/2009 - 01/2013
Extramural, Anxiolytic and Abuse-Related effectsd of BZ Ligands, NIDA/R01 DA11792-11S101/2009 - 01/2011
Extramural, GABAA Receptor Subtypes, Hypnotics, and Cognition, Sepracor SRC Grant Program ESCR092 (individual Research Agreement)01/2008 - 01/2010
Extramural, Molecular and Genetic Adaptations Associated with Compulsive Cocaine intake, NIDA/R01 DA2142001/2007 - 01/2010
Extramural, Conflict Studies in Rhesus Monkeys, Neurogen Corporation (Research Agreement)01/2007 - 01/2008
Extramural, GABA-A Receptor Subtype Mechanisms in Nonhuman Primate Models of Alcohol Abuse, NIAAA/R01 AA016179-0601/2006 - 01/2017
Extramural, GABA-A Receptor Mechanisms in Benzodiazepine Dependence, NIDA/F31 DA2030401/2006 - 01/2008
Extramural, Evaluation of Compounds for Abuse Potential, AstraZeneca Drug Discovery (Research Agreement)01/2006 - 01/2008
Extramural, Abuse of Benzodiazepine/Heroin Combinations, NIDA/F32 DA1847301/2005 - 01/2006
Extramural, Primate MOdel of the Transition to Cocaine Addiction, NIDA/R21 DA01708701/2004 - 01/2007
Extramural, Evaluation of Novel Compounds for Abuse Potential, Merck, Sharp & Dohme Research Laboratories-Terlings Park (UK) (Research Agreement)01/2003 - 01/2005
Extramural, Evaluation of Novel Anxiolytics for Merck-San Diego, Merck Research Laboratories-San Diego (Research Agreement)01/2002 - 01/2003
Extramural, Nonhuman Primate Model of Benzodiazepine Relapse, NIDA/R03 DA1359101/2001 - 01/2004
Extramural, Evaluation of Compounds for Abuse and Anxiolytic Activity, Sepracor Inc. Master study Agreement (Individual Research Project)01/2000 - 01/2009
Extramural, Anxiolytic Effects and Abuse of BZ Receptor Ligands, NIDA/R01 DA11792-1901/1998 - 01/2019
Extramural, Anxiolytic Effects and Abuse of BZ Receptor Ligands, NIDA/R01 DA11792-1401/1998 - 01/2014
Extramural, Primate Models of Speedball Abuse: Mechanisms & Treatment., NIDA/R01 DA1192801/1998 - 01/2009
Extramural, Analysis of Behavior Controlled by Drug Injections., NIDA/R01 DA0049901/1997 - 01/2004
Extramural, Self-Administation of Cocaine-Heroin Combinatins., NiDA/F32 DA0562501/1993 - 01/1996

Publications

Journal Article

Townsend EA, Platt DM, Rowlett JK, Roma PG, Freeman KB Reinforcing effectiveness of midazolam, ethanol, and sucrose: behavioral economic comparison of a mixture relative to its component solutions. Behav Pharmacol. 2017 May 19. doi: 10.1097/FBP.0000000000000308. [Epub ahead of print]2017
Huskinson SL, Naylor JE, Townsend EA, Rowlett JK, Blough BE, Freeman KB Self-administration and behavioral economics of second-generation synthetic cathinones in male rats. Psychopharmacology (Berl). 2017, 234(4):589-598.2017
Vallender EJ, Goswami DB, Shinday NM, Westmoreland SV, Yao WD, Rowlett JK Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration. Drug Alcohol Depend. 2017, 175:9-23.2017
Huskinson SL, Freeman KB, Petry NM, Rowlett JK Choice between variable and fixed cocaine injections in male rhesus monkeys. Psychopharmacology (Berl). 2017, doi: 10.1007/s00213-017-4659-9. [Epub ahead of print]2017
Chandler CM, Follett ME, Porter NJ, Liang KY, Vallender EJ, Miller GM, Rowlett JK, Platt DM Persistent negative effects of alcohol drinking on aspects of novelty-directed behavior in male rhesus macaques Alcohol. 2017, 63: 19-262017
Fischer BD, Platt DM, Rallapalli SK, Namjoshi OA, Cook JM, Rowlett JK Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis. Drug Alcohol Depend. 2016, 158:22-9.2016
Meng Z, Rowlett JK Self-administration of progesterone and synthetic neuroactive steroids by male rhesus monkeys. Drug Alcohol Depend. 2016, 165:265-92016
Huskinson SL, Myerson J, Green L, Rowlett JK, Woolverton WL, Freeman KB Shallow discounting of delayed cocaine by male rhesus monkeys when immediate food is the choice alternative. Exp Clin Psychopharmacol. 2016, 24:456-463.2016
Gunter BW, Jones SA, Paul IA, Platt DM, Rowlett JK Benzodiazepine and neuroactive steroid combinations in rats: anxiolytic-like and discriminative stimulus effects. Psychopharmacology (Berl). 2016, 233:3237-47.2016
Yasuda K, Oh K, Ren B2, Tickle TL, Franzosa EA, Wachtman LM, Miller AD, Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM, Rowlett JK, Gevers D, Huttenhower C, Morgan XC Biogeography of the intestinal mucosal and luminal microbiome in the rhesus macaque. Cell Host Microbe 2015, 17: 385-91.2015
Gunter BW, Platt DM, Rowlett JK Differential interactions engendered by benzodiazepine and neuroactive steroid combinations on schedule-controlled responding in rats. Pharmacol Biochem Behav 2015, 137: 53-9.2015
Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model. Int J Med Chem. 2015, 430248. doi: 10.1155/2015/430248. (Epub).2015
Zhang J, Saur T, Duke AN, Grant SG, Platt DM, Rowlett JK, Isacson O, Yao WD Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95. J Neurogenet 2014, 28: 98-1112014
Huskinson SL, Naylor JE, Rowlett JK, Freeman KB Predicting abuse potential of stimulants and other dopaminergic drugs: Overview and recommendations. Neuropharmacology, Special Issue on CNS stimulants 2014, 87: 66-80.2014
Licata SC1, Shinday NM2, Huizenga MN3, Darnell SB3, Sangrey GR3, Rudolph U1, Rowlett JK2, Sadri-Vakili G3. Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment. PLoS One. 2013 Dec 19;8(12):e84806. doi: 10.1371/journal.pone.0084806. eCollection 2013.2013
Lynch LJ1, Sullivan KA, Vallender EJ, Rowlett JK, Platt DM, Miller GM. Trace amine associated receptor 1 modulates behavioral effects of ethanol Subst Abuse. 2013 Jun 4;7:117-26. doi: 10.4137/SART.S12110. Print 2013.2013
Fischer BD1, Teixeira LP, van Linn ML, Namjoshi OA, Cook JM, Rowlett JK. Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation. Psychopharmacology (Berl). 2013 May;227(2):347-54. doi: 10.1007/s00213-013-2975-2. Epub 2013 Jan 26.2013
Shinday NM, Sawyer EK, Fischer BD, Platt DM, Licata SC, Atack JR, Dawson GR, Reynolds DS, Rowlett JK. Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys. Neuropsychopharmacology. 2013 May;38(6):1006-14. doi: 10.1038/npp.2012.265. Epub 2012 Dec 272013
Makaron L1, Moran CA, Namjoshi O, Rallapalli S, Cook JM, Rowlett JK. Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys. Pharmacol Biochem Behav. 2013 Mar;104:62-8. doi: 10.1016/j.pbb.2012.12.018. Epub 2013 Jan 2.2013
Rüedi-Bettschen D, Rowlett JK, Rallapalli S, Clayton T, Cook JM, Platt DM. Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys. Alcohol Clin Exp Res. 2013 Apr;37(4):624-34. doi: 10.1111/acer.12018. Epub 2012 Nov 52013
Namjoshi OA1, Wang ZJ, Rallapalli SK, Johnson EM Jr, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM. Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes. Bioorg Med Chem. 2013 Jan 1;21(1):93-101. doi: 10.1016/j.bmc.2012.10.057. Epub 2012 Nov 15.2013
Platt DM, Rowlett JK Nonhuman primates in drug and alcohol addiction research. In: Abee c, Mansfield K, Morris T, Tardif S, eds. Nonhuman Primates in Biomedical Research, Volume 2, Elsevier Press 2012.2012
Birkett MA, Shinday NM, Kessler EJ, Meyer JS, Ritchie S, Rowlett JK. Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice. Pharmacol Biochem Behav. 2011 Jun;98(4):544-51. doi: 10.1016/j.pbb.2011.03.006. Epub 2011 Mar 212011
Fischer BD, Rowlett JK. Anticonflict and reinforcing effects of triazolam + pregnanolone combinations in rhesus monkeys. J Pharmacol Exp Ther. 2011 Jun;337(3):805-11. doi: 10.1124/jpet.111.180422. Epub 2011 Mar 16.2011
Fischer BD1, Atack JR, Platt DM, Reynolds DS, Dawson GR, Rowlett JK. Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys. Psychopharmacology (Berl). 2011 May;215(2):311-9. doi: 10.1007/s00213-010-2142-y. Epub 2010 Dec 302011
Rowlett JK1, Kehne JH, Sprenger KJ, Maynard GD. Emergence of anti-conflict effects of zolpidem in rhesus monkeys following extended post-injection intervals. Psychopharmacology (Berl). 2011 Apr;214(4):855-62. doi: 10.1007/s00213-010-2093-3. Epub 2010 Nov 202011
Licata SC, Rowlett JK. Self-administration of bretazenil under progressive-ratio schedules: behavioral economic analysis of the role intrinsic efficacy plays in the reinforcing effects of benzodiazepines. Drug Alcohol Depend 2011; 113: 157-642011
Fischer BD1, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM Jr, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, Rowlett JK. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology. 2010 Dec;59(7-8):612-8. doi: 10.1016/j.neuropharm.2010.08.011. Epub 2010 Aug 182010
Rüedi-Bettschen D, Rowlett JK, Spealman RD, Platt DM. Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms. Psychopharmacology (Berl). 2010 Jun;210(2):169-77. doi: 10.1007/s00213-009-1705-2. Epub 2009 Oct 27.2010
Platt DM, Rowlett JK, Spealman RD. Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle. J Pharmacol Exp Ther. 2010 Mar;332(3):985-95. doi: 10.1124/jpet.109.162941. Epub 2009 Dec 4.2010
Licata SC, Platt DM, Rüedi-Bettschen D, Atack JR, Dawson GR, Van Linn ML, Cook JM, Rowlett JK. Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes. Neuropharmacology. 2010 Feb;58(2):357-64. doi: 10.1016/j.neuropharm.2009.10.004. Epub 2009 Oct 22.2010
Achat-Mendes C, Valdez GR, Platt DM, Rowlett JK, Spealman RD. Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine. Psychopharmacology (Berl). 2009 Jun;204(3):489-98. doi: 10.1007/s00213-009-1480-0. Epub 2009 Feb 19.2009
Licata SC, Platt DM, Cook JM, Van Linn ML, Rowlett JK. Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys. Psychopharmacology (Berl). 2009 Apr;203(3):539-46. doi: 10.1007/s00213-008-1401-7. Epub 2008 Nov 25.2009
Platt DM, Rowlett JK, Spealman RD. Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine. Psychopharmacology (Berl). 2008 Oct;200(2):167-76. doi: 10.1007/s00213-008-1191-y. Epub 2008 May 29.2008
Han D1, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, Weed MR, Cook JM. A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. Bioorg Med Chem. 2008 Oct 1;16(19):8853-62. doi: 10.1016/j.bmc.2008.08.072. Epub 2008 Sep 2.2008
Licata SC1, Rowlett JK. Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond. Pharmacol Biochem Behav. 2008 Jul;90(1):74-89. doi: 10.1016/j.pbb.2008.01.001. Epub 2008 Jan 12.2008
Rowlett JK Subtype-selective GABAA/benzodiazepine receptor ligands for the treatment of anxiety disorders. In: Blanchard RJ, Blanchard DC, Griebel G, Nutt D, editors. Handbook of anxiety and fear. New York: Academic Press; 2008. p.223-40. (Huston JP, editor. Handbook of behavioral neuroscience: vol.17.).2008
Valdez GR, Platt DM, Rowlett JK, Rüedi-Bettschen D, Spealman RD. Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms. J Pharmacol Exp Ther. 2007 Nov;323(2):525-33. Epub 2007 Aug 16.2007
Platt DM, Rowlett JK, Spealman RD Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys. J Pharmacol Exp Ther. 2007 Aug;322(2):894-902. Epub 2007 May 152007
Rowlett JK, Lelas S. Comparison of zolpidem and midazolam self-administration under progressive-ratio schedules: consumer demand and labor supply analyses. Exp Clin Psychopharmacol. 2007 Aug;15(4):328-37.2007
Rowlett JK1, Platt DM, Yao WD, Spealman RD. Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys. J Pharmacol Exp Ther. 2007 Jun;321(3):1135-43. Epub 2007 Mar 9.2007
Rowlett JK, Duke AN, Platt DM Abuse and dependence liability of GABAA receptor modulators: Antecedents and pharmacology. IN; Enna SJ, Mohler H, editors. The GABA receptors. Totowa: Humana Press: 2007.p.143-682007
Duke AN, Platt DM, Cook JM, Huang S, Yin W, Mattingly BA, Rowlett JK. Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes. Psychopharmacology (Berl). 2006 Aug;187(3):321-30. Epub 2006 Jun 17.2006
Rowlett JK1, Lelas S, Tornatzky W, Licata SC. Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors. Psychopharmacology (Berl). 2006 Jan;184(2):201-11. Epub 2005 Dec 242006
Tiefenbacher S1, Fahey MA, Rowlett JK, Meyer JS, Pouliot AL, Jones BM, Novak MA. The efficacy of diazepam treatment for the management of acute wounding episodes in captive rhesus macaques. Comp Med. 2005 Aug;55(4):387-922005
Licata SC1, Platt DM, Cook JM, Sarma PV, Griebel G, Rowlett JK Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one]. J Pharmacol Exp Ther. 2005 Jun;313(3):1118-25. Epub 2005 Feb 1.2005
Platt DM1, Duggan A, Spealman RD, Cook JM, Li X, Yin W, Rowlett JK. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys. J Pharmacol Exp Ther. 2005 May;313(2):658-67. Epub 2005 Jan 13.2005
Lee B1, Platt DM, Rowlett JK, Adewale AS, Spealman RD Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine. J Pharmacol Exp Ther. 2005 Mar;312(3):1232-40. Epub 2004 Nov 182005
Rowlett JK1, Rodefer JS, Spealman RD. Self-Administration of cocaine-opioid combinations by rhesus monkeys: evaluation of the role of mu receptor efficacy using labor supply analysis J Pharmacol Exp Ther. 2005 Mar;312(3):1289-97. Epub 2004 Nov 18.2005
Rowlett JK, Platt DM, Lelas S, Atack JR, Dawson GR. Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):915-20. Epub 2005 Jan 11.2005
Rowlett JK1, Cook JM, Duke AN, Platt DM. Selective antagonism of GABAA receptor subtypes: an in vivo approach to exploring the therapeutic and side effects of benzodiazepine-type drugs. CNS Spectr. 2005 Jan;10(1):40-8.2005
Rowlett JK Getting back to basics: Commentary on McSweeney, Murphy, and Kowal “Regulation of drug taking by sensitization and habituation”. Exp Clin Psychopharmacol 2005; 13: 187-9.2005
Rowlett JK1, Platt DM, Spealman RD. Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J Pharmacol Exp Ther. 2004 Jul;310(1):342-8. Epub 2004 Feb 252004
de Almeida RM, Rowlett JK, Cook JM, Yin W, Miczek KA. GABAA/alpha1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice. Psychopharmacology (Berl). 2004 Mar;172(3):255-63. Epub 2003 Nov 25.2004
Platt DM1, Rowlett JK, Izenwasser S, Spealman RD. Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys. J Pharmacol Exp Ther. 2004 Mar;308(3):1030-9. Epub 2003 Nov 21.2004
Spealman RD, Lee B, Tiefenbacher S, Platt DM, Rowlett JK, Khroyan TV Triggers of relapse: nonhuman primate models of reinstated drug seeking. In: Bevins R, Bardo MT, editors. Motivational factors in the etiology of drug abuse. Lincoln (NE): University of Nebraska Press; 2004; p. 57-84. (Nebraska symposium on motivation; vol. 50.).2004
Khroyan TV, Platt DM, Rowlett JK, Spealman RD. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology (Berl). 2003 Jul;168(1-2):124-31. Epub 2003 Feb 27.2003
Platt DM, Rodefer JS, Rowlett JK, Spealman RD. Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys. Psychopharmacology (Berl). 2003 Mar;166(3):298-305. Epub 2003 Feb 13.2003
Rowlett JK, Spealman RD, Lelas S, Cook JM, Yin W. Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors. Psychopharmacology (Berl). 2003 Jan;165(3):209-15. Epub 2002 Nov 6.2003
Platt DM, Rowlett JK, Spealman RD, Cook J, Ma C Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys. Psychopharmacology (Berl). 2002 Nov;164(2):151-9. Epub 2002 Sep 42002
Rowlett JK, Rodefer JS, Spealman RD. Self-administration of cocaine, alfentanil, and nalbuphine under progressive-ratio schedules: consumer demand and labor supply analyses of relative reinforcing effectiveness. Exp Clin Psychopharmacol. 2002 Nov;10(4):367-75.2002
Platt DM1, Rowlett JK, Spealman RD. Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development. Psychopharmacology (Berl). 2002 Oct;163(3-4):265-82. Epub 2002 Jul 17.2002
Lelas S1, Rowlett JK, Spealman RD, Cook JM, Ma C, Li X, Yin W. Role of GABAA/benzodiazepine receptors containing alpha 1 and alpha 5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys. Psychopharmacology (Berl). 2002 May;161(2):180-8. Epub 2002 Mar 13.2002
Park WK, Bari AA, Jey AR, Anderson SM, Spealman RD, Rowlett JK, Pierce RC. Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. J Neurosci. 2002 Apr 1;22(7):2916-25.2002
Lelas S, Rowlett JK, Spealman RD. Isobolographic analysis of chlordiazepoxide and triazolam combinations in squirrel monkeys discriminating triazolam. Psychopharmacology (Berl). 2001 Nov;158(2):181-9.2001
Platt DM, Rowlett JK, Spealman RD. Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms. J Pharmacol Exp Ther. 2001 Nov;299(2):760-7.2001
Platt DM, Rowlett JK, Spealman RD. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology (Berl). 2001 Sep;157(2):208-16.2001
Rowlett JK, Spealman RD, Platt DM. Similar enhancement of the discriminative stimulus effects of cocaine and GBR 12909 by heroin in squirrel monkeys. Psychopharmacology (Berl). 2001 Sep;157(3):313-9.2001
Rowlett JK, Tornatzky W, Cook JM, Ma C, Miczek KA. Zolpidem, triazolam, and diazepam decrease distress vocalizations in mouse pups: differential antagonism by flumazenil and beta-Carboline-3-carboxylate-t-butyl ester (beta-CCt). J Pharmacol Exp Ther. 2001 Apr;297(1):247-53.2001
Lelas S, Rowlett JK, Spealman RD. Triazolam discrimination in squirrel monkeys distinguishes high-efficacy agonists from other benzodiazepines and non-benzodiazepine drugs. Psychopharmacology (Berl). 2001 Feb;154(1):96-1042001
Rowlett JK1, Woolverton WL. Discriminative stimulus effects of panadiplon (U-78875), a partial agonist at the benzodiazepine site, in pentobarbital-trained rhesus monkeys. Drug Alcohol Depend. 2001 Feb 1;61(3):229-362001
Wilcox KM, Rowlett JK, Paul IA, Ordway GA, Woolverton WL. On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns. Psychopharmacology (Berl). 2000 Dec;153(1):139-47.2000
Rowlett JK. A labor-supply analysis of cocaine self-administration under progressive-ratio schedules: antecedents, methodologies, and perspectives. Psychopharmacology (Berl). 2000 Dec;153(1):1-16.2000
Rowlett JK, Lelas S, Spealman RD. Transduction of the discriminative stimulus effects of zolpidem by GABA(A)/alpha1 receptors. Eur J Pharmacol. 2000 Oct 6;406(1):R9-R10.2000
Lelas S1, Spealman RD, Rowlett JK. Using behavior to elucidate receptor mechanisms: a review of the discriminative stimulus effects of benzodiazepines. Exp Clin Psychopharmacol. 2000 Aug;8(3):294-311.2000
Rowlett JK. Regulation of drug-maintained behavior: comment on Meisch (2000)relative persistence of behavior. Exp Clin Psychopharmacol. 2000 Aug;8(3):355-6; discussion 362-5.2000
Rowlett JK, Spealman RD, Platt DM. Cocaine-like discriminative stimulus effects of heroin in squirrel monkeys: role of active metabolites and opioid receptor mechanisms. Psychopharmacology (Berl). 2000 Jun;150(2):191-92000
Rush CR1, Baker RW, Rowlett JK. Discriminative-stimulus effects of zolpidem, triazolam, pentobarbital, and caffeine in zolpidem-trained humans. Exp Clin Psychopharmacol. 2000 Feb;8(1):22-36.2000
Woolverton WL, Rowlett JK, Wilcox KM, Paul IA, Kline RH, Newman AH, Katz JL. 3'- and 4'-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys. Psychopharmacology (Berl). 2000 Jan;147(4):426-352000
Khroyan TV, Barrett-Larimore RL, Rowlett JK, Spealman RD Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists. J Pharmacol Exp Ther 2000; 294: 680-7.2000
Platt DM, Rowlett JK, Spealman RD Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J Pharmacol Exp Ther 2000; 293: 1017-26.2000
Rowlett JK, Spealman RD, Lelas S. Discriminative stimulus effects of zolpidem in squirrel monkeys: comparison with conventional benzodiazepines and sedative-hypnotics. J Pharmacol Exp Ther. 1999 Dec;291(3):1233-41.1999
Spealman RD1, Barrett-Larimore RL, Rowlett JK, Platt DM, Khroyan TV. Pharmacological and environmental determinants of relapse to cocaine-seeking behavior. Pharmacol Biochem Behav. 1999 Oct;64(2):327-36.1999
Platt DM, Grech DM, Rowlett JK, Spealman RD Discriminative stimulus effects of morphine in squirrel monkeys: stimulants, opioids, and stimulant-opioid combinations. J Pharmacol Exp Ther. 1999 Sep;290(3):1092-1001999
Rowlett JK1, Wilcox KM, Woolverton WL. Discriminative stimulus effects of ethyl-beta-carboline-3-carboxylate at two training doses in rats. Psychopharmacology (Berl). 1999 Aug;145(3):324-321999
Rowlett JK1, Winger G, Carter RB, Wood PL, Woods JH, Woolverton WL Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys. Psychopharmacology (Berl). 1999 Jul;145(2):205-12.1999
Woolverton WL, Rowlett JK, Winger G, Woods JH, Gerak LR, France CP. Evaluation of the reinforcing and discriminative stimulus effects of gamma-hydroxybutyrate in rhesus monkeys. Drug Alcohol Depend. 1999 Apr 1;54(2):137-43.1999
Rowlett JK1, Spealman RD. Opioid enhancement of the discriminative stimulus effects of cocaine: evidence for involvement of mu and delta opioid receptors. Psychopharmacology (Berl). 1998 Nov;140(2):217-241998
Rowlett JK, Wilcox KM, Woolverton WL. Self-administration of cocaine-heroin combinations by rhesus monkeys: antagonism by naltrexone. J Pharmacol Exp Ther. 1998 Jul;286(1):61-9.1998
Woolverton WL, Rowlett JK. Choice maintained by cocaine or food in monkeys: effects of varying probability of reinforcement. Psychopharmacology (Berl). 1998 Jul;138(1):102-6.1998
Rowlett JK1, Woolverton WL Discriminative stimulus effects of benzodiazepine agonists and partial agonists in pentobarbital-trained rhesus monkeys. Behav Pharmacol. 1998 Mar;9(2):81-92.1998
Robinet PM, Rowlett JK, Bardo MT Individual differences in novelty-induced activity and the rewarding effects of novelty and amphetamine in rats. Behav Pro 1998; 44: 1-9.1998
Rowlett JK1, Woolverton WL Self-administration of cocaine and heroin combinations by rhesus monkeys responding under a progressive-ratio schedule. Psychopharmacology (Berl). 1997 Oct;133(4):363-711997
Rowlett JK1, Mattingly BA, Bardo MT. Locomotor activity and dopamine synthesis following 1 and 15 days of withdrawal from repeated apomorphine treatments. Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):13-8.1997
Rowlett JK, Woolverton WL. Discriminative stimulus effects of zolpidem in pentobarbital-trained subjects: I. Comparison with triazolam in rhesus monkeys and rats. J Pharmacol Exp Ther. 1997 Jan;280(1):162-73.1997
Rush CR1, Madakasira S, Goldman NH, Woolverton WL, Rowlett JK Discriminative stimulus effects of zolpidem in pentobarbital-trained subjects: II. Comparison with triazolam and caffeine in humans. J Pharmacol Exp Ther. 1997 Jan;280(1):174-881997
Rowlett JK1, Woolverton WL Assessment of benzodiazepine receptor heterogeneity in vivo: apparent pA2 and pKB analyses from behavioral studies. Psychopharmacology (Berl). 1996 Nov;128(1):1-16.1996
Acteo MD1, Bowman E, Butelman E, Englis JA, Harrish L, Jacobson AE, Mattson MV, Medzihradsky F, Patrick G, Rowlett JK, Smith CB, Winger G, Woods JH, Woolverton WL. Zipeprol: preclinical assessment of abuse potential. Drug Alcohol Depend. 1996 Oct;42(2):93-104.1996
Rowlett JK1, Massey BW, Kleven MS, Woolverton WL. Parametric analysis of cocaine self-administration under a progressive-ratio schedule in rhesus monkeys. Psychopharmacology (Berl). 1996 Jun;125(4):361-70.1996
Mattingly BA1, Fields SE, Langfels MS, Rowlett JK, Robinet PM, Bardo MT. Repeated 7-OH-DPAT treatments: behavioral sensitization, dopamine synthesis and subsequent sensitivity to apomorphine and cocaine. Psychopharmacology (Berl). 1996 May;125(1):33-42.1996
Mattingly BA1, Rowlett JK, Ellison T, Rase K Cocaine-induced behavioral sensitization: effects of haloperidol and SCH 23390 treatments. Pharmacol Biochem Behav. 1996 Mar;53(3):481-61996
Rowlett JK1, Woolverton WL. Evaluation of the effects of cocaine, heroin and naltrexone, alone and in combination, on milk drinking in rats. Behav Pharmacol. 1995 Dec;6(8):821-8291995
English JA1, Rowlett JK, Woolverton WL. Unit-price analysis of opioid consumption by monkeys responding under a progressive-ratio schedule of drug injection. J Exp Anal Behav. 1995 Nov;64(3):361-71.1995
Pierce RC1, Rowlett JK, Rebec GV, Bardo MT. Ascorbate potentiates amphetamine-induced conditioned place preference and forebrain dopamine release in rats. Brain Res. 1995 Aug 7;688(1-2):21-6.1995
Rowlett JK1, Mattingly BA, Bardo MT. Repeated quinpirole treatment: locomotor activity, dopamine synthesis, and effects of selective dopamine antagonists. Synapse. 1995 Jul;20(3):209-16.1995
Bardo MT1, Bowling SL, Rowlett JK, Manderscheid P, Buxton ST, Dwoskin LP. Environmental enrichment attenuates locomotor sensitization, but not in vitro dopamine release, induced by amphetamine. Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):397-405.1995
Bardo MT1, Rowlett JK, Harris MJ. Conditioned place preference using opiate and stimulant drugs: a meta-analysis. Neurosci Biobehav Rev. 1995 Spring;19(1):39-511995
Rowlett JK1, Gibson TR, Bardo MT. Dissociation of buprenorphine-induced locomotor sensitization and conditioned place preference in rats. Pharmacol Biochem Behav. 1994 Sep;49(1):241-5.1994
Crawford CA1, Rowlett JK, McDougall SA, Bardo MT. Age-dependent differences in the rate of recovery of striatal dopamine D1 and D2 receptors after inactivation with EEDQ. Eur J Pharmacol. 1994 Feb 3;252(2):225-31.1994
Neisewander JL1, Nonneman AJ, Rowlett JK, Bardo MT. Impaired supersensitivity to morphine following chronic naltrexone treatment in senescent rats. Neurobiol Aging. 1994 Jan-Feb;15(1):91-7.1994
Rowlett JK1, Mattingly BA, Bardo MT. Neurochemical correlates of behavioral sensitization following repeated apomorphine treatment: assessment of the role of D1 dopamine receptor stimulation. Synapse. 1993 Jun;14(2):160-81993
Bardo MT, Bowling SL, Robinet PM, Rowlett JK, Lacy M, Mattingly BA Role of D1 and D2 receptors in novelty-maintained place preference. Exp Clin Psychopharmacol 1993;1: 101-9.1993
Mattingly BA1, Rowlett JK, Lovell G. Effects of daily SKF 38393, quinpirole, and SCH 23390 treatments on locomotor activity and subsequent sensitivity to apomorphine. Psychopharmacology (Berl). 1993;110(3):320-61993
Bowling SL, Rowlett JK, Bardo MT The effects of environmental enrichment on amphetamine-stimulated locomotor activity, dopamine synthesis and dopamine release. Neuropharmacology 1993; 32: 885-93.1993
Crawford CA1, McDougall SA, Rowlett JK, Bardo MT. Depletion of dopamine binding sites and changes in dopamine and dihydroxyphenylacetic acid levels in 17- and 90-day-old rat striatum after irreversible receptor antagonism. Neurosci Lett. 1992 Mar 30;137(2):265-9.1992
Blanchard DC1, Cholvanich P, Blanchard RJ, Clow DW, Hammer RP Jr, Rowlett JK, Bardo MT. Serotonin, but not dopamine, metabolites are increased in selected brain regions of subordinate male rats in a colony environment. Brain Res. 1991 Dec 24;568(1-2):61-6.1991
Rowlett JK1, Pedigo NW Jr, Bardo MT. Catalepsy produced by striatal microinjections of the D1 dopamine receptor antagonist SCH 23390 in neonatal rats. Pharmacol Biochem Behav. 1991 Dec;40(4):829-34.1991
Rowlett JK1, Mattingly BA, Bardo MT. Neurochemical and behavioral effects of acute and chronic treatment with apomorphine in rats. Neuropharmacology. 1991 Feb;30(2):191-7.1991
Mattingly BA1, Rowlett JK, Graff JT, Hatton BJ. Effects of selective D1 and D2 dopamine antagonists on the development of behavioral sensitization to apomorphine. Psychopharmacology (Berl). 1991;105(4):501-7.1991
Pierce RC1, Rowlett JK, Bardo MT, Rebec GV. Chronic ascorbate potentiates the effects of chronic haloperidol on behavioral supersensitivity but not D2 dopamine receptor binding. Neuroscience. 1991;45(2):373-8.1991
Mattingly BA, Rowlett JK. Effects of repeated apomorphine and haloperidol treatments on subsequent behavioral sensitivity to apomorphine.1989
Neisewander JL1, Rowlett JK, Nonneman AJ, Bardo MT. Up-regulation of opiate receptors following chronic naltrexone treatment in mature and aged male and female rats. Prog Clin Biol Res. 1989;292:471-6.1989
France CP, Gerak LR, Rowlett JK, Woolverton WL, Winger G, Briscoe RJ Progress report from the testing program for stimulant and depressant drugs (1999). In: Harris LS, editor. Problems of drug dependence 1999: 67th annual scientific meeting, The College on Problems od Drug dependence, Inc., NIDA Research Monograph 180, 2000. p. 423-33.1999
Winger G, Rowlett JK, Woolverton WL, France CP, Gerak LR Progress report from the testing program for stimulant and depresant drugs (1998). In: Harris LS, editor. Problems of drug dependence 1998: 60th annual scientfic meeting, The College on Problems of Drug Dependence, Inc., NIDA Research Monograph 179, 1998. p. 381-92.1998
France CP, Gerak LR, Rowlett JK, Woolverton W, Winger G, Woods JH Progess report from the testing program for stimulant and depressant drugs (1997). In: Harris LS, editor. Problems of drug dependence 1997:59th annual scintific meeting, The College on Problems of Drug Dependence, Inc., NIDA Research Monograph 178, 1997.p.429-39.1997
Rowlett JK, Negus SS, Shippenbet TS, Mello NK, Walsh SL, Spealman RD Combined cocaine and opioid abuse: from neurobiology to the clinic. In: Harris LS, editor. Problems of drug depencence 1997:59th annual scientific meeting, The College on Problems of Drug Dependence, Inc., NIDA Research Monograph 178, 1998. p. 55-7.1997
English JA, Rowlett JK, Woolverton WL, Patrick GA, Harris LS, Winger G, Woods JH Progress report from the testing program for stimulant and depressant drugs (1995). In: Harris LS, editor. Problems of drug dependence 1995: 57th annual scientific meeting, The College on Problems of Drug Dependence, Inc., NIDA Research Monograph 162, 1996. p. 452-68.1995
Winger g, Woolverton WL, Rowlett JK, English JA, Patrick GA, Nader MA, McDaniel RE, Hawkins WT, Massey BW, Harris LS, Woods JH Progress report from the testing program for stimulant and depressant drugs (1994). In: Harris LS, editor. Problems of drug dependence 1994: 56th annual scientific meeting, The College on Problems of Drug Dependence, Inc., NIDA Research Monograph 152, 1995.p. 105-16.1994

Presentations

Paper Presentation, Self-administration of benzodiazepine and cocaine combinations by monkeys in a choice procedure: Role of GABA-A receptor subtypes., 06/01/2017, Montreal, Canada06/2017
National and International Invited Seminars/Lectures, Therapeutic Effects and Abuse of Benzodiazepine: Insights from Primate Research, University of Kentucky School of Medicine, Lexington, KY2017
Invited Symposia, Delay discounting of drug and non-drug reinforcers in rhesus monkeys: Toward a more rapid procedure. In Translational Models of Choice., International Study Group Investigating Drugs as Reinforcers (ISGIDAR), Palm Springs, CA06/2016
National and International Invited Seminars/Lectures, Benzodiazepines – at the Crossroads of Behavior and Pharmacology., President’s Invited Address at the annual meeting of the International Study Group Investigating Drugs as Reinforcers (ISGIDAR), Palm Springs, CA06/2016
Paper Presentation, Variable availability as a determinant of cocaine choice in rhesus monkeys., 78th Annual Meeting for the College on Problems of Drug Dependence, Palm Springs, California06/2016
Paper Presentation, Self-administration of benzodiazepines in cocaine-experienced monkeys: Role of GABAA receptor subtypes., 42nd Annual Convention for the Association for Behavior Analysis International, Chicago, Illinois05/2016
Invited Symposia, Bill Woolverton’s Greatest Hits: Drugs, Choice, and Consequences. Memorial Symposium honoring Dr. William Woolverton., College on Problems of Drug Dependence Annual Meeting, San Juan, Puerto Rico06/2014
National and International Invited Seminars/Lectures, Metabolic disease and cognition: unexpected links., Department of Anatomy, Boston University School of Medicine, Boston, MA2013
National and International Invited Seminars/Lectures, Mediators of cognitive processes in nonhuman primates, Tulane National Primate Research Center, Covington, LA2013
Regional Invited Seminars/Lectures, Altered expression alpha 1 and alpha2 subunits of the GABAA receptor after long-term cocaine self-administration by rhesus monkeys., The 74th Annual Meeting of the College on Problems of Drug Dependence, Inc., Palm Springs, CA06/2012
Regional Invited Seminars/Lectures, The reinforcing effects of NS11808, a novel functionally-selective GABAA receptor modulator., The 74th Annual Meeting of the College on Problems of Drug Dependence, Inc., Palm Springs, CA06/2012
Poster Presentation, Benzodiazepine self-administration in rhesus monkeys: role of alpha-1subunit-containing GABA-A receptors.FAseb J 2012; 26:660.9.2012
Regional Invited Seminars/Lectures, Acute and chronic administration of the the sedative/hypnotic zolpidem alters gene expression differentially in the mouse hippocampus. Program No. 563.01.2012 Neuroscience Meeting Planner. Online, Society for Neuroscience, New Orleans, LA2012
Regional Invited Seminars/Lectures, Individual differences in the effects of alprazolam on intradimenisional / extradimensional set shifting in rhesus monkeys. Program No. 204.09.2012 Neuroscience Meeting Planner. Online, Society for Neuroscience, New Orleans, LA2012
Regional Invited Seminars/Lectures, Insulin resistance and abdominal fat are associated with cognitive deficits in non-diabetic, aged rhesus monkeys. Program No. 921.17.2012 Neuroscience Meeting Planner. online, Society for Neuroscience, New Orleans, LA2012
Regional Invited Seminars/Lectures, Intransal GDND for Parkinson's disease: Next step in preclinical development. Program No. 856.10.2012 Neruoscience Meeting Planner. Online, Society for Neuroscience, New Orleans, LA2012
Regional Invited Seminars/Lectures, Influence of OPRM1 genotype on performance on cognitive tasks in rhesus monkeys (Macaca mulatta). Program No. 814.17.2012 Online, Society for Neuroscience, New Orleans, LA2012
Regional Invited Seminars/Lectures, Effects of triazolam on caudate and nucleus accembens dopamine levels at doses that are self-administered by rhesus monkeys. Program No. 924.10.2012. Online, Society for Neuroscience, New Orleans, LA2012
Regional Invited Seminars/Lectures, Self-administration of compounds lacking intrinsic efficacy at alpha1 subunit-containing GABAA receptors. Program No. 868.07.2012 Neuroscience Meeting Planner. Online, Society for Neuroscience, New Orleans, LA2012
Poster Presentation, Long-term cocaine self-administration by rhesus monkeys results increased expression of a1 subunits of the GABAA receptor., The 73rd Annual Meeting of the College on Problems of Drug Dependence, Inc., Hollywood, FL06/2011
Poster Presentation, Physical dependence following acute benzodiazepine administration: Role of a1 GABAA receptors., The 73th Annual Meeting of the College on Problems of Drug Dependence, Inc., Hollywood, FL06/2011
National and International Invited Seminars/Lectures, Valium Revisited: Therapeutic Implications of benzodiazepine pharmacology in monkeys., Candidate for Head of Division of Neuroscience Oregon National Primate Research Center, Beaverton, OR2011
National and International Invited Seminars/Lectures, Valium Revisited: Therapeutic Implications of benzodiazepine pharmacology in monkeys, Department of Pharmacology, University of North Texas Health Sciences Center, Dallas, TX2011
Technological Innovations, "Novel drug combinations for anxiolysis" US Provisional Patent Application 61/327,323.

This patent application is for intellectual property protection of a potential combination product, consisting of a benzodiazepine and neurozctive steroid, for the treatment of anxiety and related disorders.
2011
Poster Presentation, Behavioral pharmacology of th ea3 GABAA receptor positive modulator TP003 in monkeys. FASEB J 2011; 25: 795.1.2011
Poster Presentation, GABA-A receptor subtypes and the cognition-impairing efects of benzodiazepine-type drugs. Behav Pharmacol 2011;22 (Suppl A):e36-7., Behav Pharmacolo2011
Poster Presentation, Role of GABA-A receptor subtypes in acute physical dependence following benzodiazepine administration in squirrel monkeys. Behav Pharmacol 2011;22 (Suppl A):e41., Behav Pharmacol2011
Poster Presentation, Altered expression of a1 subunits of the GABAA receptor long-term cocaine self-administration by rhesus monkeys., Society for Neuroscience Meeting Planner, Washington, DC2011
Regional Invited Seminars/Lectures, Valium Revisited: GABAA Receptors and Abuse Potential/Invited seminar, "Frontiers in Neuroscience"., Emory Univesity and Yerkes National Primate Research Center, Atlanta, GA2009
State/Local Invited Seminars/Lectures, Valium Revisited: Therapeutic and Side Effects of GABAA Receptor Modulators., Johns Hopkins School of Medicine, Behavioral Pharmacology Research Unit, Department of Psychiatry, Baltimore, MD2009
National and International Invited Seminars/Lectures, Therapeutic and Side Effects of benzodiazepines: GABAA Receptor-Medicated Mechanisms in Primates., University Central del Caribe, Bayamon, Puerto Rico2008
State/Local Invited Seminars/Lectures, Valium Revisited: New Treatments for Anxiety., Shrewsbury High School "In-House Field Trip", Shrewsbury, MA2007
State/Local Invited Seminars/Lectures, Sedation and GABAA Modulators: Dilemmas of Definitions., CNS Discovery Division: Sepracor, Inc., Marlborough, MA2006
Regional Invited Seminars/Lectures, Therapeutic and Side Effects of Benzodiazepines: GABAA Receptor Subtype-Medicated Effects in Primeates., Department of Pharmacology, Louisiana State University School of Medicine, Shreveport, LA2006
Regional Invited Seminars/Lectures, Keynote Speaker:, Kentucky Academy Sciences Annual Meeting, Morehead, KY2006
Regional Invited Seminars/Lectures, Benzodiazepines and GABAA Receptors: Insights from Drug Discrimination Studies., Society for Stimulus Properties of Drugs Meetings, Washington, DC2005
National and International Invited Seminars/Lectures, Primate Models in Pharmacology., Neuroscience Research Centre; Merck, Sharp & Dohme, Terlings Park: Harlow, Essex, United Kingdom2005
Invited Symposia, Symposium Chair: Glutamate-what's the excitement? Annual Meeting, College on Problems of Drug Dependence, San Juan, Puerto Rico2004
Regional Invited Seminars/Lectures, Triggers of relapse: nonhuman primate models of reinstated cocaine seeking., University of Nebraska Press, Nebraska2004
State/Local Invited Seminars/Lectures, Therapeutic and side effects of benzodiazepines: Role of GABAA receptor subtypes., Colloquium Series, Department of Pharmaceutical Sciences, Northeaster University, Boston, MA2003
State/Local Invited Seminars/Lectures, Therapeutic and side effects of benzodiazepines: GABAA receptor-medicated mechanisms in primates., CNS Discovery Division, Bristol-Myers Squibb Pharma, Wallingford, CT2003
State/Local Invited Seminars/Lectures, Pharmacology of cocaine relapse: Monoamine and opioid mechanisms., Lecture Series for Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, MD2003
National and International Invited Seminars/Lectures, Relationship between the anxiolytic-like and reinforcing effects of benzodiazepine agonists on monkeys., American College of Neuropsychopharmacology Annual Meeting, San Juan, Puerto Rico2003
National and International Invited Seminars/Lectures, Which GABAA receptor medicates the behavioral effects of benzodiazepines?, Department of Experimental Psychology Invited Lecture, University of Sussex, Brighton, United Kingdom2003
State/Local Invited Seminars/Lectures, Benzodiazepines, Anxiety and Addiction: Role of GABA-A Receptors., Neuroscience and Behavior Program, University of Massachusetts-Amherst2002
National and International Invited Seminars/Lectures, Benzodiazepines, Anxiety, and Addiction: Role of GABA-A Receptors., Departments of Psychology and Pharmacy, University of Kentucky, Lexington, KY2002
National and International Invited Seminars/Lectures, Speedball Addictin: Opioid and Dopaminergic Mechanisms., Department of Psychology, University of Kentlucky, Lexington, KY2002
National and International Invited Seminars/Lectures, Benzodiazepines and anxiety: A comparative perspective., American Psychological Association Annual Meeting, Chicago, IL2002
Invited Symposia, Therapeutic and side effects of benzodiazepines: GABAA subtype-mediated mechanisms in primates., American College of Neuropsychopharmacology, San Juan, Puerto Rico2002
National and International Invited Seminars/Lectures, Behavioral pharmacology of benzodiazepines in monkeys: Role of GABA-A receptor subtypes., Neuroscience Division, Merch Research Laboratories, San Diego, CA2001
National and International Invited Seminars/Lectures, Unique pharmacology of benzodiazepine ligands in monkeys., Neuroscience Research Centre; Merck, Sharp & Dohme, Terlings Park; Harlow, Essex, United Kingdom2001
National and International Invited Seminars/Lectures, Behavioral pharmacology of novel benzodiazepine ligands in non-human primates., Pharmacology Division, Merck & Co., West Point, Pennsylvania2000
State/Local Invited Seminars/Lectures, Measurement of reinforcing effectsof drugs with progressive-ratio schedules., Behavioral Pharmacology Society and European Behavioural Pharmacology Society, Boston, MA1999
State/Local Invited Seminars/Lectures, Control Behavior by Drugs: Determinants of drug Reinforcement., Behavioral Pharmacology Society and European Behavioural Pharmacology Society, Boston, MA1999
State/Local Invited Seminars/Lectures, Abuse of cocaine-heroin combinatins ("speedballs"): mechanisms and treatment., Department of Psychology, Boston University, Boston, MA1999
National and International Invited Seminars/Lectures, Behavioral pharmacology of benzodiazepine ligands in non-human primates., Neuroscience Research Centre; Merch Sharp & Dohme, Terlings Park: Harlow, Essex, United Kingdom1999
State/Local Invited Seminars/Lectures, Anxiolytic-and abuse-related effects of benzodiazepine ligands., Department of Ps;ychology, University of Massachusetts, Amherst1998
National and International Invited Seminars/Lectures, Pharmacological manipulation of speedball self-administration under progressive-ratio schedules.

Symposium: "Pharmacological Manipulation of Drug-Seeking Behaviour"., European Behavioural Pharmacology Society 7th Biennial Meeting, Brno, Czech Republic
1998

Honors, Awards, and Recognition

Meritorious Research Award, Gold Level, University of Mississippi Medical Center2015
Fellow, Division 28 Psychopharmacology and Substance Abuse, American Psychological Association2007
Joseph Cochin Young Investigator Award, College on Problems of Drug Dependence2005
Distinguished Alumni Lecture, First Annual Founder's Day Celebration, Morehead State University, Department of Psychology2003
Outstanding Psychology Graduating Senior Award, Morehead State University1998
Director's Award, For travel to 1996 College on Problems of Drug Dependence meeting, National Institute on Drug Abuse1996
Travel Fellowship, College on Problems of Drug Dependence1995
Dissertation Year Fellowship, University of Kentucky1992
Honors Convocation Invited Address, Morehead State University1988
President Merit Scholarship, Scholarship based on academic merit, Morehead State University1984
Honor Society, Morehead State University1984

Professional Membership and Service

College on Problems of Drug Dependence, Member, Animals in Research Committee2016 - 2019
American Psychological Association, Chair, Chair, Committee on Animal Research and Ethics (CARE)2014 - 2017
Journal of the Experimental Analysis of Behavior, Editorial Review Board Member2011 - 2014
American Psychological Association, Member, Committee on Animal Research and Ethics (CARE)2007 - 2008
Fellow, Division 28: Psychoparmacology and Substance Abuse, Member2007 - Present
American College of Neuropsychopharmacology, Member2004 - 2012
International Study Group Investigating Drugs as Reinforcers, Member2004 - Present
American Psychological Association, Member, Chair, Committee on Animal Research and Ethics (CARE)2003 - 2008
National Alliance for Biomedical Research, Member2003 - Present
Behavioral Pharmacology Society, Member2002 - Present
National Research Council, Ad hoc member, Committee on National Needs for Biomedical and Behavioral Sciences, office of Scientific and Engineering Personnel1997
American Association for the Advancement of Science, Member1997 - Present
College on Problems of Drug Dependence, Member1994 - Present
Society for Stimulus Properties of Drugs, Member1993 - Present
American Psychological Association, Member1993 - Present
Society for Neuroscience, Member1989 - Present

Committee Service

Flagship Constellation-Brain Wellness, Member2017 - Present
University Research Advisory Council2016 - Present
Faculty Search Committee, Department of Neurobiology & Anatomical Sciences, Member2014 - Present
Member, Workstream Group to select Electronic IACUC form vendor, Harvard Medical School, Member2012 - 2012
Chair, Rodent Use Steering Committee, New England Primate Research Center, Chair2011 - 2012
Chair, Committee on Resource-Related Research Program, New England Primate Research Center, Chair2010 - 2013
Chair, Committee on Pilot Project Programs, New England Primate Research Center, Chair2008 - 2013
Chair, Cognitive Neuroscience Faculty Search Committee, New England Primate Research Center, Chair2008 - 2010
Faculty Search Committee, New England Primate Research Center, Member2004 - 2005
Resource and Animal Allocation Committee, New England Primate Rsearch Center, Member2000 - 2011
Herpes B Virus Policy Committee, New England Primate Research Center, Member1999 - 2013
Committee on National Needs for Biomedical and Behavioral Sciences, Office of Scientific and Engineering Personnel, Ad hoc Member1997 - 1997
Animal Reserch Review Committee, New England Primate Research Center, Member1997 - 2013

Other Service

ETTM-11, Small Business Grants Panel2015 - 12/2017
ZDA1 GXM-A (09) S, Cutting-Edge Basic Research Awards03/2014 - 03/2014
Journal of the Experimental Analysis of Behavior2011 - 12/2014
ZRG1 BBBP-R (32) Special Emphasis Panel for Shared Instrumentation Grants10/2009 - 10/2009
ZRG1 BBBP-R (95) Recovery Act of 2009 Study Section06/2009 - 06/2009
Biobehavioral Regulation, Learning and Ethology (BRLE), Charter Member2005 - 12/2012
NIDA Contract Review, RFP N01DA-1-7725, Contract review01/2001 - 01/2001
Psychopharmacology Special Issue on Reinforcing Effects of Drugs, Issue 153 (1), 2000, Guest Editor
Translational Psychiatry
Science
F1000 Reviews
Psychoneuroendocrinology
Psychopharmacology
PLOS ONE
Physiology and Behavior
Pharmacological Research
Pharmacology, Biochemistry, and Behavior
Neuropsychopharmacology
Nature Neuroscience
Molecular Psychiatry
Journal of Pharmacology and Experimental Therapeutics
Journal of the Experimental Analysis of Behavior
Experimental and Clinical Psychopharmacology
European Journal of Pharmacology
Drug and Alcohol Dependence
Behavioural Pharmacology
Brain Research
Biological Psychiatry
Behavioral Neuroscience Fellowship Panel, 2014
ZRG1 BBBP-Y (03) M; Center for Scientific Review Special Emphasis Panel, 2014

Teaching Experience

NSCI 721, Medicine, Lecture, Course Presenter, Scientific Writing in NeuroscienceAnnual 2016
Medicine, Lecture, Course Presenter, Anxiolytics and Drug AbuseAnnual 2015
NSCI 701, Medicine, Lecture, Course Presenter, AnxiolyticsAnnual 2014

Directed Student Learning

Research Advisor, Advised: Lais Berro2017 - Present
Dissertation Committee Member, Advised: Edward Townsend2015 - 2017
Research Advisor, Advised: James Cook2014 - Present
Research Advisor, Advised: Sally Huskinson2013 - 2015
Dissertation Committee Chair, Advised: Barack Gunter2013 - 2016
Dissertation Committee Member, Advised: Jennifer Naylor2013 - 2015
Master's Thesis Committee Member, Advised: Sarah McKenzie2013 - 2013
Research Advisor, Advised: Eileen Sawyer2012 - 2013
Research Advisor, Advised: Zhiqiang Meng2010 - 2015
Research Advisor, Advised: Leah Makaron2009 - 2011
Dissertation Committee Member, Advised: Eileen Sawyer2008 - 2011
Research Advisor, Advised: Bradford Fischer2008 - 2012
Research Advisor, Advised: Angela Duke2008 - 2009
Master's Thesis Committee Member, Advised: Yibei Chen2007 - 2008
Dissertation Committee Chair, Advised: Nina Shinday2006 - 2013
Master's Thesis Committee Member, Advised: Dominik Biezonski2005 - 2006
Dissertation Committee Chair, Advised: Melissa Birkett2005 - 2008
Research Advisor, Advised: Stephanie Licata2004 - 2006
Dissertation Committee Chair, Advised: Angela Duke2003 - 2008
Dissertation Committee Member, Advised: Brian Piper2003 - 2006
Dissertation Defense Committee Member, Advised: Ausaf Bari2003 - 2005
Qualifying Exam Committee, Advised: Yolanda Black2000 - 2001
Dissertation Committee Member, Advised: Stephanie Collins Reed1998 - 1999
Research Advisor, Advised: Snjezana Lelas1998 - 2001
Dissertation Committee Member, Advised: Stefan Tiefenbacher1998 - 1999
Supervised Research, Advised: Summer Undergraduate Student Internship program1998 - 2003
Dissertation Committee Member, Advised: Kristin Wilcox1997 - 1999