Donna "Donna Platt" M. Rowlett, PhD

Donna "Donna Platt" M. Rowlett, PhD

Division Chief

Department:
SOM-Psychiatry

Email:
dplatt@umc.edu

Work Phone:
(601) 984-5896

Education

University of Massachusetts-Amherst, PhD, Zoology1997
University of Massachusetts-Amherst, MA, Zoology1994
Franklin & Marshall College, BA, Biology1991

Current Positions

Professor, School of Medicine, Department of Psychiatry07/2018 - Present
Director, School of Graduate School in the Health Sciences07/2016 - Present
Associate Professor, School of Medicine, Department of Neurobiology and Anatomical Sciences2014 - Present
Associate Professor, School of Medicine, Department of Psychiatry08/2013 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Associate Director, University of Mississippi Medical Center, School of Graduate School in the Health Sciences, Department of Graduate Program in Neuroscience, SGSHS10/2014 - 06/2016
Assistant Professor, Harvard Medical School/New England Regional Primate Research Center, School of Medicine, Department of Psychiatry2009 - 08/2013
Instructor, Harvard Medical School/New England Regional Primate Research Center, School of Medicine, Department of Psychiatry2002 - 2009
Core Scientist, Harvard Medical School/New England Regional Primate Research Center, School of Medicine2002 - 08/2013
Research Fellow, Harvard Medical School/New England Regional Primate Research Center, School of Medicine1997 - 2002
Research Assistant II, Harvard Medical School/New England Regional Primate Research Center, School of Medicine, Department of Behavioral Biology1996 - 1997
Research Assistant, University of Massachusetts - Amherst, Department of Psychology1992 - 1996
Teaching Assistant, University of Massachusetts - Amherst, Department of Zoology1991 - 1995

Sponsored Program Funding

Extramural, Genome-Based Approaches to Understanding Behaviors Underlying Addiction in an Animal Model, NIDA07/2018 - 06/2023
Extramural, R21 AA 26001, Behavioral and molecular effects of early-life alcohol exposure: GABA-A receptor mechanisms, NIAAA04/2018 - 03/2020
Extramural, R01 DA 43204, Tolerance and physical dependence after chronic benzodiazepine treatment, NIDA07/2017 - 06/2022
Extramural, R01 DA 45022, Short- and long-term consequences of methamphetamine use during pregnancy, NIDA04/2017 - 03/2022
Extramural, Local Chapter Award, Society for Neuroscience06/2016 - 05/2017
Extramural, R01 DA 39167, Deterrents for prescription opioid abuse, NIDA09/2015 - 08/2020
Extramural, R01 DA 33795, Neurosteriod-BZ combinations: Strategy for reducing abuse and sedation., NIDA06/2012 - 04/2018
Extramural, NPY Ligands for the Treatment of Cocaine Addiction, Addiction Therapeutix01/2011 - 12/2011
Extramural, R01 AG 35361, Novel GABAA modulators as cognitive enhancers., NIA08/2010 - 07/2015
Extramural, Novel GABAergic Compounds as Anti-Alcohol Pharmacotherapies, Addiction Therapeutix01/2010 - 12/2011
Extramural, 5P51 RR 0168-48S5, New England Primate Research Center Base Grant: ARRA Pilot Project. "Development of a cognitive biomarker for alcoholism", NCRR01/2010 - 12/2011
Extramural, R01 AA 16828, Opioid receptor polymorphisms and nonhuman primate models of alcohol abuse., NIAAA06/2009 - 07/2016
Extramural, P51 RR 00168, NEPRC Base grant: Pilot research project: Naturalistic modeling of alcoholism genotype/phenotype relationships and naltrexone pharmacogenomics in rhesus monkey"., NCRR09/2008 - 08/2009
Extramural, R01 DA 11054, Nonhuman Primate Models of Reinstated Cocaine Seeking., NIDA08/2007 - 07/2012
Extramural, R21 AA 016194, Alcohol Abuse Pharmacogenomics: Building Naturalistic Rhesus Monkey Models., NIAAA03/2007 - 02/2009
Extramural, R01 DA 24315, Strategies for Enhancing Extinction of Drug-Seeking Behavior., NIDA01/2007 - 12/2012
Extramural, R01 DA 17700, MGluR Mechanisms in Primate Models of Cocaine Abuse., NIDA08/2006 - 07/2011
Extramural, R01 AA 16179, GABAA receptor subtype mechanisms in nonhuman primate models of alcohol abuse., NIAAA06/2006 - 08/2018
Extramural, R01 DA 11928, Nonhuman Primate Models of Speedball Abuse., NIDA07/2003 - 06/2008
Extramural, R21 AA 13850, GABAA/a5 Ligands in Primate Models of Alcohol Abuse., NIAAA03/2003 - 02/2006
Extramural, R01 DA 00499, Analysis of Behavior Controlled by Drug Injections., NIDA02/1999 - 12/2004
Extramural, R01 DA 11792, Anxiolytic Effects and Abuse of Benzodiazepine Receptor Ligands., NIDA06/1998 - 12/2019
Extramural, MH 14275, Research Training- Biological Sciences., NIMH01/1998 - 12/1999

Publications

Journal Article

Platt DM, Novak MA Perception of novel changes in a familiar environment by socially-housed rhesus monkeys. Am J Primatol. 1999;47(2):117-31
Platt DM, Grech DM, Rowlett JK, Spealman RD. Discriminative stimulus effects of morphine in squirrel monkeys: stimulants, opioids, and stimulant-opioid combinations. J Pharmacol Exp Ther. 1999 Sep;290(3):1092-100.
Rowlett JK, Spealman RD, Platt DM. Cocaine-like discriminative stimulus effects of heroin in squirrel monkeys: role of active metabolites and opioid receptor mechanisms. Psychopharmacology (Berl). 2000 Jun;150(2):191-9.
Platt DM, Rowlett JK, Spealman RD. Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J Pharmacol Exp Ther. 2000 Jun;293(3):1017-26.
Platt DM, Rowlett JK, Spealman RD. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology (Berl). 2001 Sep;157(2):208-16.
Rowlett JK1, Spealman RD, Platt DM. Similar enhancement of the discriminative stimulus effects of cocaine and GBR 12909 by heroin in squirrel monkeys. Psychopharmacology (Berl). 2001 Sep;157(3):313-9.
Platt DM, Rowlett JK, Spealman RD. Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms. J Pharmacol Exp Ther. 2001 Nov;299(2):760-7.
Platt DM, Rowlett JK, Spealman RD, Cook J, Ma C Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys. Psychopharmacology (Berl). 2002 Nov;164(2):151-9. Epub 2002 Sep 4
Platt DM, Rodefer JS, Rowlett JK, Spealman RD. Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys. Psychopharmacology (Berl). 2003 Mar;166(3):298-305. Epub 2003 Feb 13.
Khroyan TV, Platt DM, Rowlett JK, Spealman RD. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology (Berl). 2003 Jul;168(1-2):124-31. Epub 2003 Feb 27.
Lee B, Tiefenbacher S, Platt DM, Spealman RD. Role of the hypothalamic-pituitary-adrenal axis in reinstatement of cocaine-seeking behavior in squirrel monkeys. Psychopharmacology (Berl). 2003 Jul;168(1-2):177-83. Epub 2003 Mar 22.
Spealman RD, Lee B, Tiefenbacher S, Platt DM, Rowlett JK, Khroyan TV. Triggers of relapse: nonhuman primate models of reinstated cocaine seeking. Nebr Symp Motiv. 2004;50:57-84.
Platt DM, Novak MA Videostimulation as enrichment for captive rhesus monkeys (Macaca Mulatta). Appl Anim Behav Sci. 1997; 52:139-155.
Platt DM, Rowlett JK, Izenwasser S, Spealman RD. Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys. J Pharmacol Exp Ther. 2004 Mar;308(3):1030-9. Epub 2003 Nov 21.
Lee B, Tiefenbacher S, Platt DM, Spealman RD. Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys. Neuropsychopharmacology. 2004 Apr;29(4):686-93.
Rowlett JK, Platt DM, Spealman RD. Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J Pharmacol Exp Ther. 2004 Jul;310(1):342-8. Epub 2004 Feb 25.
Lee B, Platt DM, Rowlett JK, Adewale AS, Spealman RD. Attenuation of behavioral effects of cocaine by the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine. J Pharmacol Exp Ther. 2005 Mar;312(3):1232-40. Epub 2004 Nov 18.
Platt DM, Duggan A, Spealman RD, Cook JM, Li X, Yin W, Rowlett JK. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys. J Pharmacol Exp Ther. 2005 May;313(2):658-67. Epub 2005 Jan 13.
Rowlett JK, Platt DM, Lelas S, Atack JR, Dawson GR. Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):915-20. Epub 2005 Jan 11.
Licata SC, Platt DM, Cook JM, Sarma PV, Griebel G, Rowlett JK. Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one]. J Pharmacol Exp Ther. 2005 Jun;313(3):1118-25. Epub 2005 Feb 1.
Platt DM, Carey G, Spealman RD. Intravenous self-administration techniques in monkeys. Curr Protoc Neurosci. 2005 Aug;Chapter 9:Unit 9.21. doi: 10.1002/0471142301.ns0921s32.
Hodge CW, Grant KA, Becker HC, Besheer J, Crissman AM, Platt DM, Shannon EE, Shelton KL. Understanding how the brain perceives alcohol: neurobiological basis of ethanol discrimination. Alcohol Clin Exp Res. 2006 Feb;30(2):203-13.
Duke AN, Platt DM, Cook JM, Huang S, Yin W, Mattingly BA, Rowlett JK. Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes. Psychopharmacology (Berl). 2006 Aug;187(3):321-30. Epub 2006 Jun 17.
Adewale AS, Platt DM, Spealman RD. Pharmacological stimulation of group II metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys. J Pharmacol Exp Ther. 2006 Aug;318(2):922-31. Epub 2006 May 4.
Rowlett JK, Platt DM, Yao WD, Spealman RD. Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys. J Pharmacol Exp Ther. 2007 Jun;321(3):1135-43. Epub 2007 Mar 9.
Platt DM, Rowlett JK, Spealman RD. Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys. J Pharmacol Exp Ther. 2007 Aug;322(2):894-902. Epub 2007 May 15
Valdez GR, Platt DM, Rowlett JK, Rüedi-Bettschen D, Spealman RD. Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms. J Pharmacol Exp Ther. 2007 Nov;323(2):525-33. Epub 2007 Aug 16.
Platt DM, Rowlett JK, Spealman RD. Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine. Psychopharmacology (Berl). 2008 Oct;200(2):167-76. doi: 10.1007/s00213-008-1191-y. Epub 2008 May 29.
Licata SC, Platt DM, Cook JM, Van Linn ML, Rowlett JK. Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys. Psychopharmacology (Berl). 2009 Apr;203(3):539-46. doi: 10.1007/s00213-008-1401-7. Epub 2008 Nov 25
Achat-Mendes C, Valdez GR, Platt DM, Rowlett JK, Spealman RD. Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine. Psychopharmacology (Berl). 2009 Jun;204(3):489-98. doi: 10.1007/s00213-009-1480-0. Epub 2009 Feb 19.
Achat-Mendes C, Platt DM, Newman AH, Spealman RD. The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys. Psychopharmacology (Berl). 2009 Sep;206(1):73-84. doi: 10.1007/s00213-009-1581-9. Epub 2009 Jun 10.
Rüedi-Bettschen D, Rowlett JK, Spealman RD, Platt DM. Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms. Psychopharmacology (Berl). 2010 Jun;210(2):169-77. doi: 10.1007/s00213-009-1705-2. Epub 2009 Oct 27.
Nic Dhonnchadha BA, Szalay JJ, Achat-Mendes C, Platt DM, Otto MW, Spealman RD, Kantak KM. D-cycloserine deters reacquisition of cocaine self-administration by augmenting extinction learning. Neuropsychopharmacology. 2010 Jan;35(2):357-67. doi: 10.1038/npp.2009.139.
Licata SC1, Platt DM, Rüedi-Bettschen D, Atack JR, Dawson GR, Van Linn ML, Cook JM, Rowlett JK. Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes. Neuropharmacology. 2010 Feb;58(2):357-64. doi: 10.1016/j.neuropharm.2009.10.004. Epub 2009 Oct 22.
Vallender EJ, Rüedi-Bettschen D, Miller GM, Platt DM. A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys. Drug Alcohol Depend. 2010 Jun 1;109(1-3):252-6. doi: 10.1016/j.drugalcdep.2010.01.005. Epub 2010 Feb 13.
Platt DM, Rowlett JK, Spealman RD. Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle. J Pharmacol Exp Ther. 2010 Mar;332(3):985-95. doi: 10.1124/jpet.109.162941. Epub 2009 Dec 4.
Achat-Mendes C, Grundt P, Cao J, Platt DM, Newman AH, Spealman RD. Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. J Pharmacol Exp Ther. 2010 Aug;334(2):556-65. doi: 10.1124/jpet.110.167619. Epub 2010 May 21.
Yin W, Majumder S, Clayton T, Petrou S, VanLinn ML, Namjoshi OA, Ma C, Cromer BA, Roth BL, Platt DM, Cook JM. Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. doi: 10.1016/j.bmc.2010.08.049. Epub 2010 Sep 29.
Platt DM, Bano KM. Opioid receptors and the discriminative stimulus effects of ethanol in squirrel monkeys: Mu and delta opioid receptor mechanisms. Eur J Pharmacol. 2011 Jan 10;650(1):233-9. doi: 10.1016/j.ejphar.2010.09.064. Epub 2010 Oct 15.
Fischer BD, Atack JR, Platt DM, Reynolds DS, Dawson GR, Rowlett JK. Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys. Psychopharmacology (Berl). 2011 May;215(2):311-9. doi: 10.1007/s00213-010-2142-y. Epub 2010 Dec 30.
Platt DM, Carey G, Spealman RD. Models of neurological disease (substance abuse): self-administration in monkeys. Curr Protoc Pharmacol. 2011 Dec;Chapter 10:Unit10.5. doi: 10.1002/0471141755.ph1005s56.
Achat-Mendes C, Nic Dhonnchadha BÁ, Platt DM, Kantak KM, Spealman RD. Glycine transporter-1 inhibition preceding extinction training inhibits reacquisition of cocaine seeking. Neuropsychopharmacology. 2012 Dec;37(13):2837-45. doi: 10.1038/npp.2012.155. Epub 2012 Sep 5.
Achat-Mendes C, Platt DM, Spealman RD Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys. J Pharmacol Exp Ther. 2012 Oct;343(1):214-24. doi: 10.1124/jpet.112.196295. Epub 2012 Jul 18.
Rüedi-Bettschen D, Rowlett JK, Rallapalli S, Clayton T, Cook JM, Platt DM. Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys. Alcohol Clin Exp Res. 2013 Apr;37(4):624-34. doi: 10.1111/acer.12018. Epub 2012 Nov 5.
Shinday NM, Sawyer EK, Fischer BD, Platt DM, Licata SC, Atack JR, Dawson GR, Reynolds DS, Rowlett JK. Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys. Neuropsychopharmacology. 2013 May;38(6):1006-14. doi: 10.1038/npp.2012.265. Epub 2012 Dec 27.
Lynch LJ, Sullivan KA, Vallender EJ, Rowlett JK, Platt DM, Miller GM. Trace amine associated receptor 1 modulates behavioral effects of ethanol. Subst Abuse. 2013 Jun 4;7:117-26. doi: 10.4137/SART.S12110. Print 2013.
Sawyer EK, Moran C, Sirbu MH, Szafir M, Van Linn M, Namjoshi O, Tiruveedhula VVPB, Cook JM, Platt DM. Little Evidence of a Role for the α1GABAA Subunit-Containing Receptor in a Rhesus Monkey Model of Alcohol Drinking. Alcohol Clin Exp Res. 2014 Apr;38(4):1108-17. doi: 10.1111/acer.12320. Epub 2013 Dec 13.
Zhang J, Saur T, Duke AN, Grant SGN, Platt DM, Rowlett JK, Isacson O, Yao W-D Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95 J Neurogenet 2014; 28:98-111
Helms CM, Anderson SM, Bell RL, Bennett AJ, Davies DL, Chester JA, Kosten TA, Leeman RF, Panicker S, Platt DM, Weiner JL, Edwards S The importance of animals in advancing research on alcohol use disorders Alcohol Clin Exp Res. 2015; 39:575-278
Ruedi-Bettschen D, Spealman RD, Platt DM Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors Psychopharmacology. 2015; 232:2959-2968
Gunter BW, Platt DM, Rowlett JK Differential interactions engendered by benzodiazepine and neuroactive steroid combinations on schedule-controlled responding in rats Pharmacol Biochem Behav. 2015; 137:53-59
Fischer BD, Platt DM, Rallapalli SK, Namjoshi OA, Cook JM, Rowlett JK Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis Drug Alcohol Depend. 2016; 158:22-29
Gunter BW, Jones SA, Paul IA, Platt DM, Rowlett JK. Benzodiazepine and neuroactive steroid combinations in rats: Anxiolytic-like and discriminative stimulus effects. Psychopharmacology. 2016; 233:3237-3247
Sweeney CG, Rando JM, Panas HN, Miller GM, Platt DM, Vallender EJ Convergent balancing selection of the mu-opioid receptor in primates. Mol Biol Evol. 2017; 34:1629-1643
Ruedi-Bettschen D, Platt DM Detrimental effects of self-administered methamphetamine during pregnancy on offspring development in the rat. Drug Alcohol Depend. 2017; 177:171-177
Townsend EA, Platt DM, Rowlett JK, Roma PG, Freeman KB Reinforcing effectiveness of midazolam, ethanol, and sucrose: Behavioral economic comparison of a mixture relative to its component solutions. Behav Pharmacol. 2017; 28:386-393
Chandler CM, Follett ME, Porter NJ, Liang KY, Vallender EJ, Miller GM, Rowlett JK, Platt DM Persistent negative effects of alcohol drinking on aspects of novelty-directed behavior in male rhesus macaques. Alcohol. 2017; 63:19-26

Review Article

Spealman RD, Barrett-Larimore RL, Rowlett JK, Platt DM, Khroyan TV. Pharmacological and environmental determinants of relapse to cocaine-seeking behavior. Pharmacol Biochem Behav. 1999 Oct;64(2):327-36.
Platt DM, Rowlett JK, Spealman RD. Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development. Psychopharmacology (Berl). 2002 Oct;163(3-4):265-82. Epub 2002 Jul 17.
Rowlett JK, Cook JM, Duke AN, Platt DM Selective antagonism of GABAA receptor subtypes: an in vivo approach to exploring the therapeutic and side effects of benzodiazepine-type drugs. CNS Spectr. 2005 Jan;10(1):40-8.

Abstracts

Ruedi-Bettschen D, Neal MB, Platt D In utero exposure to moderate doses of methamphetamine alters sensitivity to the same drug in adults Proceedings from the 79th Annual Meeting of the College on Problems of Drug Dependence. 20172017
Chandler CM, Reeves-Darby J, Jones S, Rahman M, Li G, Cook J, Platt DM Alpha5 GABA-A receptors, a potential therapeutic target for the treatment of alcohol related disorders: Evidence from rodent studies Alcohol Clin Exp Res. 2017; 41:117A2017
Platt DM, Ruedi-Bettschen D, Cook LE, Li G, Poe M, Methuku K, Cook JM Contribution of alpha 2/3 GABA-A receptors to the abuse-related effects of ethanol in rhesus monkeys Alcohol Clin Exp Res. 2017; 41:116A2017
Chandler CM, Reeves-Darby J, Jones SA, Platt DM Involvement of GABA-A receptors expressing the alpha5 subunit in the reinstatement of alcohol seeking in rats Soc Neurosci Abstr. 2016; 828.162016
Gunter BW, Jones SA, Platt D, Rowlett JK Anxiolytic-like and discriminative stimulus effects of benzodiazepine+neuroactive steroid combinations in rats Proceedings from the 78th Annual Meeting of the College on Problems of Drug Dependence. 20162016
Townsend EA, Rowlett JK, Platt DM, Freeman KB Comparison of the reinforcing efficacy of midazolam, ethanol, and mixtures of the two in male rats Proceedings from the 78th Annual Meeting of the College on Problems of Drug Dependence. 20162016
Chandler CM, Reeves-Darby J, Rallapalli S, Cook J, Platt DM Modulation of relapse-like drinking by ligands selective for alpha5 GABA-A receptors Alcohol Clin Exp Res. 2016; 40:147A2016
Platt DM, Miller GM, Vallender EJ, Rowlett JK Relationship between cognitive performance and alcohol intake in rhesus monkeys Alcohol Clin Exp Res. 2016; 40:148A2016
Ruedi-Bettschen D, Chawla S, Washington CS, Platt DM Consequences of self-administered methamphetamine throughout pregnancy on rat dams and their offspring Soc Neurosci Abstr. 2015; 317.042015
Platt DM, Vallender EJ, Rowlett JK, Miller GM Effects of OPRM1 genotype on opioid pharmacology in rhesus monkeys: In vitro and in vivo evidence Proceedings of the 16th Biennial Meeting of the European Behavioural Pharmacology Society. 20152015
Rowlett JK, Gunter BW, Follett ME, Freeman KB, Platt DM Benzodiazepine consumption by monkeys, rats, and mice Proceedings of the 16th Biennial Meeting of the European Behavioural Pharmacology Society. 20152015
Chandler CM, Follett ME, Vallender E, Miller G, Platt DM Persistent negative effects of alcohol drinking on novel object recognition in rhesus monkeys Alcohol Clin Exp Res. 2015; 39:56A2015
Ruedi-Bettschen D, Rallapalli S, Clayton T, Cook J, Platt DM Reinforcing effects of ethanol are attenuated by alpha5 GABA-A receptor inverse agonists in monkeys Alcohol Clin Exp Res. 2015; 39:60A2015
Gunter BW, Platt DM, Freeman KB, Rowlett JK Reinstatement of drug-seeking behavior in rats trained to self-administer intravenous injections of midazolam Proceedings from the 77th Annual Meeting of the College on Problems of Drug Dependence. 20152015
Rowlett JK, Duke AN, Platt DM, Namjoshi O, Tiruveedhula VVNPB, Van Linn ML, Cook JM Evidence for sedative effects of benzodiazepines involving unexpected GABAA receptor subtypes Proceedings from the 77th Annual Meeting of the College on Problems of Drug Dependence. 20152015
Platt D, Sawyer E, Vallender E, Miller G OPRM1 genotype-dependent sensitivity to the behavioral effects of ethanol in rhesus monkeys Alcohol Clin Exp Res. 20142014
Platt D, Moran C, Sawyer E, Sirbu M, VanLinn M, Namjoshi O, Clayton T, Cook J Little role for alpha1GABA-A receptor subtypes in the reinforcing effects of ethanol in rhesus monkeys Alcohol Clin Exp Res. 2013; 37:247A2013
Sawyer EK, Sirbu MH, Vallender EJ, Miller GM, Platt DM Influence of OPRM1 genotype on induction and maintenance of alcohol drinking in monkeys Proceedings from the Annual Meeting of Experimental Biology. 20132013
Shinday NM, Sawyer EK, Fischer BD, Platt DM, Licata SC, Atack JR, Dawson GR, Reynolds DS, Rowlett JK Self-administration of compounds lacking intrinsic efficacy at alpha1 subunit containing GABAA receptors Soc Neurosci Abstr. 2012; 868.072012
Vallender EJ, Sweeney CG, Xie Z, Panas HN, Platt DM, Miller GM Functional genetic models and tools for translational research: Comparative studies of the mu-opioid receptor Soc Neurosci Abstr. 2012; 873.042012
Moran CA, Musen G, Platt DM, Wachtman LM, Leboeuf S, Liang KY, Porter NJ, Bolo NR, Jacobson AM, Kaufman MJ, Miller A, Sawyer EK, Simonson DC, Taheri F, Yasuda K, Westmoreland SV, Rowlett JK Insulin resistance and abdominal fat are associated with cognitive deficits in non-diabetic, aged rhesus monkeys Soc Neurosci Abstr. 2012; 921.172012
Miller GM, Platt DM, Vallender EJ, Lynch LJ, Sullivan KA, Ogawa LM Trace amine associated receptor 1 (TAAR1) involvement in alcohol drinking behaviors Soc Neurosci Abstr. 2012; 454.052012
Meng Z, Duke AN, Platt DM, Rowlett JK Individual differences in the effects of alprazolam on intradimensional/extradimensional set shifting in rhesus monkeys Soc Neurosci Abstr. 2012; 204.092012
Platt DM, Miller GM, Vallender EJ, Rowlett JK, Liang KY, Lynch LJ, Porter NJ Influence of OPRM1 genotype on performance on cognitive tasks in rhesus monkeys Soc Neurosci Abstr. 2012; 814.172012
Platt D, Ruedi-Bettschen D, Vallender E, Miller G Relationship between OPRM1 genotype and the effects of alcohol and naltrexone in rhesus monkeys self-administering alcohol Alcohol Clin Exp Res. 2012; 36:263A2012
Miller GM, Madras BK, Panas HN, Platt DM, Vallender EJ Advancing the rhesus monkey model for opioid research: Discovery of a novel nonsynonomous variant in the kappa opioid receptor gene Soc Neurosci Abstr. 2011; 341.262011
Platt DM, Rüedi-Bettschen D, Vallender EJ, Miller GM OPRM1 genotype-dependent effects of alcohol and naltrexone in rhesus monkeys trained to self-administer alcohol Behav Pharmacol. 2011; 22:e482011
Achat-Mendes C, Nic Dhonnchadha BA, Hede-Brierley L, Whaley J, Platt DM, Kantak KM, Spealman RD Inhibiting glycine transporter-1 during extinction training attenuates reacquisition of cocaine self-administration in squirrel monkeys and rats Proceedings from the 73rd Annual Meeting of the College on Problems of Drug Dependence. 20112011
Vallender EJ, Xie Z, Platt DM, Miller GM A naturally occurring genetic model of human mu-opioid receptor genetic variation INRC Abstr. 20112011
Miller GM, Chen G-L, Platt DM, Vallender EJ Exploiting the parallel functional polymorphisms and pharmacogenomic responsivity between rhesus monkeys and humans for drug discovery: A new avenue for preclinical modeling to advance personalized medicine for psychiatric and addictive disease Proceedings from the NIDA/NIAAA Satellite Symposium at the World Congress of Psychiatric Genetics – Genetics and Epigenetics of Substance Abuse. 20112011
Shinday NM, Platt DM, Yao WD, Rowlett JK Evidence for an “escalation” effect, but not locomotor sensitization, in cocaine self-administering rhesus monkeys Soc Neurosci Abstr. 2010; 888.212010
Vallender EJ, Platt DM, Miller GM Comparative primate genetics: A new tool for neuroscience connecting function and disease Soc Neurosci Abstr. 2010; 323.72010
Szafir ME, Van Linn M, Namjoshi O, Yin W, Clayton T, Cook J, Platt DM Evaluation of alpha1/GABAA receptor mechanisms in the reinforcing effects of ethanol in rhesus monkeys Soc Neurosci Abstr. 2010; 66.82010
Platt DM, Ruedi-Bettschen D, Rowlett JK, Rallapalli S, Clayton T, Cook JM Alpha5/GABA-A receptor inverse agonists attenuate the abuse-related effects of ethanol in monkeys Alcohol Clin Exp Res. 2010; 34:5382010
Nic Dhonnchadha BA, Achat-Mendes C, Platt DM, Pinard E, Alberati D, Wettstein JG, Spealman RD, Kantak KM Inhibiting glycine transporter-1: Effects on extinction and reacquisition of cocaine self-administration Proceedings from the 72nd Annual Meeting of the College on Problems of Drug Dependence. 20102010
Shinday NM, Platt DM, Rowlett JK, Yao W-D Evidence for tolerance to the behavioral effects of cocaine after long-term self-administration by rhesus monkeys Proceedings from the 72nd Annual Meeting of the College on Problems of Drug Dependence. 20102010
Shinday NM, Platt DM, Yao W, Rowlett JK Locomotor-activating and other behavioral effects of long-term cocaine self-administration in rhesus monkeys Soc Neurosci Abstr. 2009; 553.16.2009
Achat-Mendes C, Platt DM, Spealman RD Attenuation of the discriminative stimulus effects of cocaine by the mGluR1 antagonist JNJ16259685 in squirrel monkeys Soc Neurosci Abstr. 2009; 551.32009
Platt DM, Ruedi-Bettschen D, Rallapalli S, Van Linn M, Namjoshi O, Cook JM Alpha-5/GABAA, but not alpha-1/GABAA, receptor mechanisms contribute to the reinforcing effects of ethanol in monkeys Behav Pharmacol. 2009; 20:S69-702009
Achat-Mendes C, Valdez GR, Platt DM, Rowlett JK, Spealman RD Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: Comparison with heroin and antagonism by naltrexone and naloxonazine Proceedings from the 71st Annual Meeting of the College on Problems of Drug Dependence. 20092009
Shinday NM, Platt DM, Rowlett JK, Yao WD Self-administered cocaine does not result in locomotor sensitization in monkeys Proceedings from the 71st Annual Meeting of the College on Problems of Drug Dependence. 20092009
Fischer BD, Platt DM, Van Linn M, Rallapalli S, Clayton T, Cook JM, Rowlett JK Role of GABAA receptor subtypes in benzodiazepine self-administration by rhesus monkeys Proceedings from the 71st Annual Meeting of the College on Problems of Drug Dependence. 20092009
Platt DM, Van Linn M, Rallapalli S, Clayton T, Cook JM GABA-A receptor subtype mechanisms in the discriminative stimulus effects of ethanol in monkeys Proceedings from the 71st Annual Meeting of the College on Problems of Drug Dependence. 20092009
Fischer BD, Bano KM, Duke AN, Platt DM, He X, Huang Q, Johnson EM, Furtmuller R, Sieghart W, Cook JM, Rowlett JK In vitro and in vivo characterization of the novel benzodiazepine analog NEP-510 Soc Neurosci Abstr. 2008; 849.52008
Achat-Mendes C, Platt DM, Newman AH, Grundt P, Spealman RD Comparison of selective dopamine D2 and D3 receptor antagonists on cocaine’s abuse-related behaviors in squirrel monkeys Soc Neurosci Abstr. 2008; 766.122008
Lemere CA, Rowlett JK, Carville A, Platt DM, Licata SC, Harper-Castle S, Westmoreland SV, Curran EH, Sun J, Pepivani I, Hagen M, Eldridge JH, Jacobsen J, Pangalos MN, Seubert P, Johnson-Wood K, Motter R, Schenk D, Games D, Mansfield KG Beneficial effects of active amyloid-beta immunotherapy on cognition and plaque burden in aged Caribbean vervets Soc Neurosci Abstr. 2008; 11.102008
Ruedi-Bettschen D, Harper-Castle S, Clayton T, Rallapalli S, Cook JM, Platt DM Alpha-5/GABA(A) receptor mechanisms and the reinforcing effects of ethanol in monkeys Proceedings from the 70th Annual Meeting of the College on Problems of Drug Dependence. 20082008
Duke AN, Platt DM, Rowlett JK Tolerance develops differentially to the sedative effects of alprazolam following chronic treatment in rhesus monkeys Proceedings from the 70th Annual Meeting of the College on Problems of Drug Dependence. 20082008
Achat-Mendes C, Platt DM, Kantak KM, Spealman RD D-cycloserine augments extinction learning and delays re-acquisition of cocaine self-administration in squirrel monkeys Proceedings from the 70th Annual Meeting of the College on Problems of Drug Dependence. 20082008
Achat-Mendes C, Platt DM, Spealman RD, Newman AH Modulation of the reinforcing and discriminative stimulus effects of cocaine by the dopamine D3 receptor partial agonist CJB 090 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-4-(pyridine-2-yl)benzamide] in squirrel monkeys Proceedings from the ASPET meeting. 20082008
Ruedi-Bettschen D, Spealman RD, Platt DM Involvement of 5-HT2C receptor mechanisms in the serotonergic modulation of cocaine priming-induced reinstatement in squirrel monkeys Soc Neurosci Abstr. 2007; 912.102007
Duke AN, Platt DM, Van Linn ML, Sarma PVVS, Cook JM, Rowlett JK Evaluation of precipitated withdrawal by flumazenil and BCCT following chronic alprazolam administration in rhesus monkeys Soc Neurosci Abstr. 2007; 810.72007
Bano KM, Platt DM, Sarma PVVS, Van Linn ML, Cook JM, Rowlett JK Antagonism of the reinforcing effects of triazolam by selective antagonists in rhesus monkeys Soc Neurosci Abstr. 2007; 810.62007
Achat-Mendes C, Valdez GR, Platt DM, Teixeira L, Rowlett JK, Spealman RD Self-administration of opioid-cocaine combinations in rhesus monkeys: Effects of naltrexone and naloxonazine Soc Neurosci Abstr. 2007; 387.152007
Rowlett JK, Platt DM, Duke AN, Bano KM Cocaine self-administration under extended access conditions in rhesus monkeys: Lack of “escalation”? Behav Pharm. 2007; 18:S642007
Platt DM, Ruedi-Bettschen D, Rallapalli S, Cook JM Role of alpha-5/GABA(A) receptor mechanisms in the reinforcing effects of ethanol in monkeys Behav Pharm. 2007; 18:S29-S302007
Ruedi-Bettschen D, Bano KM, Spealman RD, Platt DM Serotonergic modulation of cocaine priming-induced reinstatement: Focus on 5-HT2C receptor mechanisms Proceedings of the College on Problems of Drug Dependence 69th Annual Meeting. 20072007
Platt DM, Van Linn M, Clayton T, Cook JM, Rowlett JK GABA-A/alpha5 receptor mechanisms in the discriminative stimulus effects of GABA-A modulators Proceedings of the College on Problems of Drug Dependence 69th Annual Meeting. 20072007
Duke AN, Platt DM, Cook JM, Van Linn ML, Rowlett JK Differential antagonism of the sedative and motor effects of zolpidem and alprazolam by BCCT Proceedings of the College on Problems of Drug Dependence 69th Annual Meeting. 20072007
Achat-Mendes C, Platt DM, Grundt P, Langer S, Bano K, Newman AH, Spealman RD Novel D3 receptor antagonists and partial agonists attenuate the discriminative stimulus effects of cocaine and reinstatement of cocaine seeking in squirrel monkeys Proceedings of the College on Problems of Drug Dependence 69th Annual Meeting. 20072007
Duke AN, Platt DM, Licata SC, Edwanker R, Huang S, Cook JM, Furtmueller R, Sieghart W, Rowlett JK Differential sedative and motor effects of GABAA subtype-selective compounds in rhesus monkeys Soc Neurosci Abstr. 2006; 168.172006
Ruedi-Bettschen D, Miller GM, Bano KM, Platt DM Mu opioid receptor polymorphisms and naltrexone response in rhesus monkeys trained to self-administer alcohol Soc Neurosci Abstr. 2006; 192.92006
Platt DM, Rowlett JK, Spealman RD Role of mu and delta opioid receptor subtypes in the discriminative stimulus effects of ethanol in monkeys Alcohol Clin Exp Res2006
Rowlett JK, Platt DM, Dawson GR, Atack JR GABA-A receptor subtypes and clinically-relevant effects of benzodiazepines: Anti-conflict and reinforcing effects of L-822,696 in primates Proceedings of the College on Problems of Drug Dependence 68th Annual Meeting. 20062006
Licata SC, Platt DM, Dawson GR, Atack JR, Rowlett JK GABA-A receptor subtypes and clinically-relevant effects of benzodiazepines: Observable behavior and discriminative stimulus effects of L-822,696 in primates Proceedings of the College on Problems of Drug Dependence 68th Annual Meeting. 20062006
Valdez GR, Platt DM, Rowlett JK, Spealman RD Kappa opioid agonist-induced reinstatement of cocaine seeking in squirrel monkeys via stress-related mechanisms Proceedings of the College on Problems of Drug Dependence 68th Annual Meeting. 20062006
Duke AN, Platt DM, Cook JM, Yin W, Rowlett JK Attenuation of the motor and sedative-like effects of alprazolam by flumazenil and BCCT in rhesus monkeys Proceedings of the College on Problems of Drug Dependence 68th Annual Meeting. 20062006
Birkett MA, Platt DM, Tiefenbacher S, Rowlett JK A “pharmacological stressor” model of anxiolysis in monkeys: Alprazolam attenuation of the behavioral and physiological effects of yohimbine Neuropsychopharmacology. 2005; 30: S2352005
Licata SC, Platt DM, Cook JM, Zhou H, Sarma PVVS, Furtmueller R, Sieghart W, Huck S, Rowlett JK Neurochemical and behavioral effects of novel 8-acetylenyl analogs of triazolam. Soc Neurosci Abstr. 2005; 1035.52005
Birkett MA, Platt DM, Tiefenbacher S, Bano KM, Rowlett JK Attenuation of the effects of a pharmacological stressor by alprazolam in squirrel monkeys Soc Neurosci Abstr. 2005; 778.82005
Platt DM, Rowlett JK, Spealman RD Discriminative stimulus effects of cocaine and heroin in rhesus monkeys: Mu and delta opioid receptor mechanisms Proceedings of the College on Problems of Drug Dependence 67th Annual Meeting. 20052005
Rowlett JK, Platt DM, Spealman RD Attenuation of cocaine self-administration by the mGluR5 antagonist MPEP: Comparison with the NMDA antagonist dizocilpine Proceedings of the College on Problems of Drug Dependence 67th Annual Meeting. 20052005
Duke AN, Platt DM, Rowlett JK Behavioral effects of alprazolam in rhesus monkeys: Relationship with anti-conflict and reinforcing effects Proceedings of the College on Problems of Drug Dependence 67th Annual Meeting. 20052005
Valdez GR, Platt DM, Rowlett JK, Spealman RD Kappa opioid agonists induce partial reinstatement of cocaine seeking-behavior via non-opioid mechanisms Proceedings of the College on Problems of Drug Dependence 67th Annual Meeting. 20052005
Licata SC, Platt DM, Rowlett JK Comparison of the discriminative stimulus effects and reinforcing effects of heroin-benzodiazepine combinations in rhesus monkeys Proceedings of the College on Problems of Drug Dependence 67th Annual Meeting. 20052005
Platt DM Role of GABAA receptor subtypes in the discriminative stimulus effects of alcohol in monkeys Alcohol Clin Exp Res. 2005; 29: 177A2005
Duke AN, Platt DM, Lelas S, Langer SE, Rowlett JK Self-administration and observable behavioral effects of zolpidem in rhesus monkeys: Comparison with midazolam Soc Neurosci Abstr. 2005; 1000.142005
Platt DM, Rowlett JK, Spealman RD Contrasting effects of the dopamine D2 receptor partial agonist terguride in behavioral studies with squirrel monkeys Soc Neurosci Abstr. 2004; 807.8.2004
Duke AN, Meyer JS, Schraut M, Sarma P, Cook JM, Platt DM, Lee B, Rowlett JK The GABAA/alpha-1 receptor-preferring antagonist BCCT does not attenuate benzodiazepine-induced suppression of locomotor activity Soc Neurosci Abstr. 2004; 1026.132004
Licata SL, Platt DM, Duke AN, Cook JM, Sarma P, Rowlett JK GABA-A receptor mechanisms underlying motor effects of benzodiazepines in squirrel monkeys Soc Neurosci Abstr. 2004; 583.152004
Valdez GR, Platt DM, Rowlett JK, Spealman RD Modulation of the discriminative stimulus effects and self-administration of cocaine by etonitazene in rhesus monkeys Soc Neurosci Abstr. 2004; 122.12004
Platt DM, Rowlett JK, Spealman RD Kappa agonist modulation of cocaine priming-induced reinstatement: Kappa opioid and serotonergic mechanisms Proceedings of the College on Problems of Drug Dependence 66th Annual Meeting. 20042004
Duke AN, Platt DM, Cook JM, Yin W, Rowlett JK GABAA/alpha1 receptor involvement in the hyperphagic effect of benzodiazepines in squirrel monkeys Proceedings of the College on Problems of Drug Dependence 66th Annual Meeting. 20042004
Licata SC, Platt DM, Rowlett JK Behavioral effects of the functionally selective GABA-A receptor agonist SL651498 in monkeys Proceedings of the College on Problems of Drug Dependence 66th Annual Meeting. 20042004
Rowlett JK, Platt DM, Spealman RD Attenuation of cocaine and food self-administration by the mGluR5 antagonist MPEP Proceedings of the College on Problems of Drug Dependence 66th Annual Meeting. 20042004
Platt DM, Rowlett JK, Spealman RD, Cook JM, Li X, Yin W GABA-A/alpha1 and alpha5 receptor mechanisms in the discriminative stimulus effects of ethanol in squirrel monkeys Alcohol Clin Exp Res. 2004; 28:62A2004
Rowlett JK, Platt DM, Spealman RD Opposite modulation of heroin self-administration by dopamine D1- and D2-like agonists Proceedings of the College on Problems of Drug Dependence 65th Annual Meeting. 20032003
Platt DM, Rowlett JK, Spealman RD Asymmetric interactions between the discriminative stimulus effects of cocaine and heroin in rhesus monkeys Proceedings of the College on Problems of Drug Dependence 65th Annual Meeting. 20032003
Duke AN, Platt DM, Spealman RD, Cook JM, Li X, Rowlett JK Elucidating benzodiazepine receptor subtype mechanisms using zolpidem and the putative GABAA/alpha5 selective agonist QH-ii-066 Proceedings of the College on Problems of Drug Dependence 65th Annual Meeting. 20032003
Platt DM, Rowlett JK, Spealman RD, Cook JM, Yin W Role of GABAA/alpha5 receptor mechanisms in the discriminative stimulus effects of ethanol in squirrel monkeys Alcohol Clin Exp Res. 2003; 27: 128A2003
Platt DM, Rowlett JK, Spealman RD Opposite modulation of reinstated cocaine seeking by mu- and kappa-opioid agonists Soc Neurosci Abstr. 2002; 806.12002
Platt DM, Rodefer JS, Khroyan TV, Rowlett JK, Spealman RD Cocaine-modulating effects of terguride in nonhuman primate models of cocaine abuse Drug Alcohol Depend. 2002; 66: S139-S1402002
Lee B, Tiefenbacher S, Platt DM, Rowlett JK, Spealman RD Role of HPA axis in relapse to cocaine-seeking behavior Soc Neurosci Abstr. 2001; 27: 978.42001
Platt DM, Rowlett JK, Spealman RD, Cook JM, Yin W Role of GABAA/alpha1 receptor mechanisms in the discriminative stimulus effects of ethanol in squirrel monkeys Proceedings of the FASEB Summer Research Conference ‘Commonalities and Differences in the Mechanisms of Alcohol and Other Drugs of Abuse’. 20012001
Rowlett JK, Spealman RD, Platt DM Cocaine-like discriminative stimulus effects of heroin: Role of monoaminergic mechanisms. Drug Alcohol Depend. 2001; 63: S1362001
Platt DM, Rowlett JK, Spealman RD Modulation of the discriminative stimulus effects of heroin by 3-methoxynaltrexone in rhesus monkeys Drug Alcohol Depend. 2001; 63: S1232001
Platt DM, Rowlett JK, Spealman RD Monoaminergic transport mechanisms in relapse to cocaine-seeking behavior Soc Neurosci Abstr. 2001; 27: 788.22001
Platt DM, Spealman RD, Rowlett JK, Malinak SA Contribution of GABAA/alpha1 receptor mechanisms to the discriminative stimulus effects of ethanol in monkeys. Soc Neurosci Abstr. 2000; 26: 2802000
Lelas S, Platt DM, Rowlett JK, Spealman RD, Cook JM, Ma C Discriminative stimulus effects of the novel 1,4-benzodiazepine QH-ii-66 in ethanol- and triazolam-trained squirrel monkeys. Soc Neurosci Abstr. 2000; 26: 2802000
Platt DM, Rowlett JK, Spealman RD Discriminative stimulus effects of intravenous heroin in rhesus monkeys. Drug Alcohol Depend. 2000; 60:S1722000
Platt DM, Rowlett JK, Spealaman RD Unconditioned behavioral effects of zolpidem and triazolam in squirrel monkeys: Differentiation by flumazenil. Behav Pharmacol. 1999; 10: S731999
Rowlett JK, Spealman RD, Platt DM Heroin and 6-monoacetylmorphine partially mimic the stimulus effects of cocaine. Pharmacol Biochem Behav. 1999; 64:6511999
Platt DM, Rowlett JK, Spealman RD Modulation of cocaine self-administration by full and partial D1 agonists. NIDA Res Monogr. 1999; 180: 1131999
Platt DM, Rowlett JK, Spealman RD Suppression of cocaine self-administration by D1 partial agonists. Soc Neurosci Abstr. 1998; 24: 21351998
Platt DM, Spealman RD, Rowlett JK Cocaine-antagonist properties of the D1 partial agonist SKF 83959 in squirrel monkeys. NIDA Res Monogr. 1998; 179: 1781998
Kinsey JH, Jorgensen MJ, Platt DM, Hazen TJ Food puzzle feeders: Effects on self-biting and stereotypy in individually housed monkeys Proceedings of the XVIth Congress of the International Primatological Society/XIXth Conference of the American Society of Primatologists. 19961996
Platt DM, Kinsey JH, Jorgensen MJ, Novak MA Factors affecting the expression of self-injurious behavior in rhesus monkeys (Macaca mulatta). Proceedings of the XVIth Congress of the International Primatological Society/XIXth Conference of the American Society of Primatologists. 19961996
Platt D, Novak M, Kinsey J, Price C, Suomi S Cognitive mapping skills in rhesus monkeys (Macaca mulatta). Am J Primatol. 1995; 36: 1491995
Platt D, Novak M Active and passive forms of video stimulation in rhesus macaques Am J Primatol. 1994; 33: 2341994
Platt D, Price C, Novak M, Suomi S Mapping skills in rhesus monkeys (Macaca mulatta) Proceedings of the 31st Annual Meeting of the Animal Behaviour Society. 19941994
Spealman RD, Khroyan TV, Barrett-Larimore RL, Rowlett JK, Platt DM Dopaminergic mechanisms in relapse to cocaine-seeking behavior: Implications for medications development. Ann NY Acad Sci. 2000; 909: 273-274

Book Chapter

Rowlett JK, Duke AN, Platt DM Abuse and dependence liability of GABAA receptor modulators: Antecedents and pharmacology, in the Receptors: The GABA Receptors, Third Edition (Enna SJ and Mohler H, eds.) Humana Press, New Jersey, 2007
Platt DM, Rowlett JK Nonhuman primates in drug and alcohol addiction research. In: Abee C, Mansfield K, Morris T, Tardif S, eds. Volume 2: Nonhuman Primates in Biomedical Research, 2nd Edition, pp. 817-840, Elsevier Press

Presentations

Poster Presentation, Contribution of alpha 2/3 GABA-A receptors to the abuse-related effects of ethanol in rhesus monkeys, Research Society on Alcoholism 69th Annual Meeting, Denver, CO06/2017
Poster Presentation, Relationship between cognitive performance and alcohol intake in rhesus monkeys, Research Society on Alcoholism 68th Annual Meeting, New Orleans, LA06/2016
State/Local Invited Seminars/Lectures, Nonhuman primates: Evolution, ecology & behavior, Center for Comparative Research, UMMC, Jackson, MS05/2016
Regional Invited Seminars/Lectures, Pharmacogenetic approaches to understanding and treating substance abuse disorders, Mississippi State University, Starkville, MS03/2016
Regional Invited Seminars/Lectures, Pursuing a career in neuroscience, Mississippi State University, Starkville, MS12/2015
Regional Invited Seminars/Lectures, Pursuing a career in neuroscience, University of Mississippi, Oxford, MS11/2015
National and International Invited Seminars/Lectures, Pharmacotherapies for cocaine abuse: Serotonergic approaches, FDA/National Center for Toxicological Research, Little Rock, AR09/2015
Poster Presentation, Effects of OPRM1 genotype on opioid pharmacology in rhesus monkeys: In vitro and in vivo evidence, 16th Biennial Meeting of the European Behavioural Pharmacology Society, Verona, Italy09/2015
Poster Presentation, Reinforcing effects of ethanol are attenuated by alpha5 GABA-A receptor inverse agonists in monkeys, Research Society on Alcoholism 67th Annual Meeting, San Antonio, TX06/2015
State/Local Invited Seminars/Lectures, Pharmacogenetic approaches to understanding and treating substance abuse disorders, Department of Neurobiology & Anatomical Sciences, Jackson, MS10/2014
Poster Presentation, OPRM1 genotype-dependent sensitivity to the behavioral effects of ethanol in rhesus monkeys, Research Society on Alcoholism 66th Annual Meeting, Bellevue, WA06/2014
National and International Invited Seminars/Lectures, Advocating for animal research, Research Sociaety on Alcoholism, Bellevue, WA06/2014
State/Local Invited Seminars/Lectures, Naltrexone & OPRM1 polymorphisms: Using pharmacogenetic approaches to treat alcohol use disorders, Center for Psychiatric Neuroscience, UMMC & School of Pharmacy, University of Mississippi, Jackson, MS05/2014
State/Local Invited Seminars/Lectures, Modeling personalized medicine for alcohol use disorders: Insights from non-human primates, Department of Psychiatry & Human Behavior, Jackson, MS04/2014
Poster Presentation, Little role for alpha1GABA-A receptor subtypes in the reinforcing effects of ethanol in rhesus monkeys, Research Society on Alcoholism 65th Annual Meeting, Orlando, FL06/2013
Poster Presentation, Influence of OPRM1 genotype on performance on cognitive tasks in rhesus monkeys, Society for Neuroscience 42nd Annual Meeting, New Orleans, LA11/2012
Poster Presentation, Relationship between OPRM1 genotype and the effects of alcohol and naltrexone in rhesus monkeys self-administering alcohol, Research Society on Alcoholism 35th Annual Meeting, San Francisco, CA06/2012
Poster Presentation, OPRM1 genotype-dependent effects of alcohol and naltrexone in rhesus monkeys trained to self-administer alcohol, 14th Biennial Meeting of the European Behavioural Pharmacology Society, Amsterdam, Netherlands09/2011
Poster Presentation, Alpha5/GABA-A receptor inverse agonists attenuate the abuse-related effects of ethanol in monkeys, Research Society on Alcoholism 33rd Annual Meeting, San Antonio, TX06/2010
Poster Presentation, Alpha-5/GABAA, but not alpha-1/GABAA, receptor mechanisms contribute to the reinforcing effects of ethanol in monkeys, 13th Biennial Meeting of the European Behavioural Pharmacology Society, Rome, Italy09/2009
Platform Presentations, GABA-A receptor subtype mechanisms in the discriminative stimulus effects of ethanol in monkeys, College on Problems of Drug Dependence 71st Annual Meeting, Reno, NV06/2009
State/Local Invited Seminars/Lectures, Using nonhuman primate models to understand alcohol use disorders, Veterinary Clinical Residency Program, NEPRC, Southborough, MA04/2009
Poster Presentation, Role of alpha-5/GABA(A) receptor mechanisms in the reinforcing effects of ethanol in monkeys, 12th Biennial Meeting of the European Behavioural Pharmacology Society, Tuebingen, Germany09/2007
Poster Presentation, GABA-A/alpha5 receptor mechanisms in the discriminative stimulus effects of GABA-A modulators., College on Problems of Drug Dependence 69th Annual Meeting, Quebec City, Canada06/2007
Poster Presentation, Role of mu and delta opioid receptor subtypes in the discriminative stimulus effects of ethanol in monkeys., Research Society on Alcoholism 29th Annual Meeting, Baltimore, MD06/2006
Poster Presentation, Discriminative stimulus effects of cocaine and heroin in rhesus monkeys: Mu and delta opioid receptor mechanisms., College on Problems of Drug Dependence 67th Annual Meeting, Orlando, FL06/2005
Invited Symposia, Role of GABAA receptor subtypes in the discriminative stimulus effects of alcohol in monkeys., Research Society on Alcoholism 28th Annual Meeting, Santa Barbara, CA06/2005
Poster Presentation, Constrasting effects of the dopamine D2 receptor partial agonist terguride in behavioral studies with squirrel monkeys., Society for Neuroscience 34th Annual Meeting, San Diego, CA11/2004
Platform Presentations, Kappa agonist modulation of cocaine priming-induced reinstatement: Kappa opioid and serotonergic mechanisms., College on Problems of Drug Dependence 66th Annual Meeting, San Juan, Puerto Rico06/2004
Poster Presentation, GABA-A/alpha1 and alpha5 receptor mechanisms in the discriminative stimulus effects of ethanol in squirrel monkeys., Research Society on Alcoholism 27th Annual Meeting, Vancouver, British Columbia06/2004
Poster Presentation, Asymmetric interactions between the discriminative stimulus effects of cocaine and heroin in rhesus monkeys., College on Problems of Drug Dependence 65th Annual Meeting, Bal Harbour, FL06/2003
Platform Presentations, Role of GABAA/a5 receptor mechanisms in the discriminative stimulus effects of ethanol in squirrel monkeys., Research Society on Alcoholism 26th Annual Meeting, Fort Laurderdale, FL06/2003
National and International Invited Seminars/Lectures, GABAergic Mechanisms and the Discriminative Stimulus Effects of Alcohol in Monkeys, University of Texas Health Sciences Center, Houston, TX05/2003
National and International Invited Seminars/Lectures, alpha1 and alpha5 GABA-A Receptor Subtypes & the Subjective Effects of Ethanol in Squirrel Monkeys, Wake Forest University, Winston-Salem, NC02/2003
Poster Presentation, Opposite modulation of reinstated cocaine seeking by mu-and kappa-opioid agonists., Society for Neuroscience 32nd Annual Meeting, Orlando, FL11/2002
Platform Presentations, Cocaine-modulating effects of terguride in nonhuman primate models of cocaine abuse., College on Problems of Drug Dependence 64th Annual Meeting, Quebec City, Canada06/2002
Platform Presentations, Monoaminergic transport mechanisms in relapse to cocaine-seeking behavior., Society for Neuroscience 31st, Annual Meeting, San Diego, CA11/2001
Poster Presentation, Role of GABAA/a1 Receptor Mechanisms in the Discriminative Stimulus Effects of Ethanol in Squirrel Monkeys., FASEB Summer Research Conference 'Commonalities and Differences in the mechanisms of Alcohol and Other Drugs of Abuse, Tucson, AZ08/2001
Platform Presentations, Modulation of the discriminative stimulus effects of heroin by 3-methoxynaltrexone in rhesus monkeys., College on Problems of Drug Dependence 63rd, Annual Meeting, Scottsdale, AZ06/2001
Platform Presentations, Contribution of GABAA/alpha1 receptor mechanisms to the discriminative stimulus effects of ethanol in monkeys., Society for Neuroscience 30th Annual Meeting, New Orleans, LA11/2000
Poster Presentation, Discriminative stimulus effects of intravenous heroin in rhesus monkeys., College on Problems of Drug Dependence 62nd Annual Meeting, San Juan, Puerto Rico06/2000
Poster Presentation, Unconditioned behavioral effects of zolpidem and triazolam in squirrel monkeys: Differentiation by flumazenil., Joint meeting of the Behavioral Pharmacology Society and the European Behavioral Pharmacological Society, Boston, MA08/1999
Platform Presentations, Modulation of cocaine self-administration by full and partial D1 agonists., College on Problems of Drug Dependence 61st Annual Meeting, Acapulco, Mexico06/1999
Poster Presentation, Suppression of cocaine self-administration by D1 partial agonists., Society for Neurosciene 28th Annual Meeting, Los Angeles, CA11/1998
Poster Presentation, Cocaine-antagonist properties of the D1 partial agonist SKF 83959 in squirrel monkeys., College on Problems of Drug Dependence 60th Annual Meeting, Scottsdale, Arizona06/1998
Platform Presentations, Factors affecting the expression of self-injurious behavior in rhesus monkeys (Macaca Mulatta)., XVIth Congress of the International Primatological Society/XIXth Conference of the American Society of Primatologists, Madison, Wisconsin06/1996
Platform Presentations, Cognitive mapping skills in rhesus monkeys (Macaca Mulatta)., American Society of Primatologists XVIIIth Conference, Scottsdale, Arizona06/1995
Poster Presentation, Mapping skills in rhesus monkeys (Macaca Mulatta)., Animal Behaviour Society 31st, Annual Meeting, Seattle, Washington06/1994
Platform Presentations, Active and passive forms of video stimulation in rhesus macaques., American Society of Primatologists XVIIth Conference, Seattle, Washington06/1994

Honors, Awards, and Recognition

Excellence in Research Award-Gold level, UMMC2016
Excellence in Research Award-Silver level, UMMC2014
Summer Research Conference Travel Award, FASEB2001
Early Career Investigator Travel Fellowship, College on Problems of Drug Dependence1998
Black Pyramid Senior Honor Society, Franklin & Marshall College1990
John Marshall Scholar, Franklin & Marshall College1987

Professional Membership and Service

Committee on Animal Research and Ethics; Research Society on Alcoholism, Officer, Other Officer2016 - Present
Mississippi Chapter of the Society for Neuroscience, Officer, President/Elect/Past2014 - Present
Committee on Animal Research and Ethics; Research Society on Alcoholism, Member2013 - 2016
Research Priorities Committee; Research Society on Alcoholism, Member2006 - 2010
Research Society on Alcoholism, Member2001 - Present
Society for Neuroscience, Member1998 - Present
College on Problems of Drug Dependence, Member1998 - Present
American Society of Primatologists, Member1994 - Present
Animal Behaviour Society, Member1994 - Present

Committee Service

Patient Advocacy Reporting System (PARS) Messenger, Messenger2016 - Present
SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-GRADUATE COUNCIL, Member2016 - Present
Executive Committee for the Program in Neuroscience, Chair2016 - Present
Curriculum Committee for the Program in Neuroscience, Chair2016 - Present
Curriculum Committee for the Program in Neuroscience, Member2015 - 2016
Recruitment/Admissions Committee for the Program in Neuroscience, Chair2014 - 2016
Promotions & Tenure Committee for Department of Psychiatry & Human Behavior, Member2014 - Present
Executive Committee for the Program in Neuroscience, Member2013 - 2016
Harvard University Laboratory Safety Committee-HMS, Member2013 - 2013
Quality Assurance/Improvement Committee-New England Primate Research Center, Member2012 - 2013
Clinical Veterinarian Search Committee-New England Primate Research Center, Member2011 - 2011
Laboratory Safety Committee-New England Primate Research Center, Chair2009 - 2013
Occupational Health and Safety Nurse Search Committee-New England Primate Research Center, Member2009 - 2009
Laboratory Safety Committee-New England Primate Research Center, Member2003 - 2013
Database Design Committee-New England Primate Research Center, Member2003 - 2004
Postdoctoral Steering Committee-Harvard Medical School, Member1999 - 2003

Community Service

Classroom visit/lecture, St. Anthony Catholic School, lecturer10/2017 - 10/2017
St. Anthony Catholic School Science Fair, judge01/2017 - 01/2017
Classroom visit/lecture, St. Anthony Catholic School, lecturer10/2016 - 10/2016

Other Service

National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel: Review/Reverse Site Visit of ARC Grant Applications (P50/P60), ZAA1 GG(60)07/2017 - 07/2017
National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel: Target of Low Dose Alcohol, ZAA1 JJ(08), ZAA1 GG(71)07/2016 - 07/2016
National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel: Review/Reverse Site Visit of ARC Grant Applications (P50/P60), ZAA1, GG(69), ZAA1 GG(71)07/2015 - 08/2015
Center for Psychiatric Neuroscience, Pilot Grant Program04/2015 - 04/2015
Center for Scientific Review, Neurobiology of Motivated Behavior (NMB) Study Section, Charter/Regular Member06/2014 - Present
National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel: Neuroscience Review Subcommittee, AA406/2014 - 06/2014
Center for Psychiatric Neuroscience, Pilot Grant Program03/2014 - 03/2014
National Center for Research resources, Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities, Chair09/2013 - 10/2013
The French National Research Agency (ANR), Programme de Recherche Translationnelle en Sante08/2013 - 08/2013
Center for Scientific Review, Neurobiology of Motivated Behavior (NMB) Study Section02/2013 - 02/2013
PLOS One2013 - Present
Biological Psychiatry2013 - Present
Addiction Biology2013 - Present
National Center for Research Resources, Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities, Chair09/2012 - 10/2012
Center for Scientific Review, Neurotoxicology and Alcohol (NAL) Study Section02/2012 - 02/2012
International Journal of Neuropsychopharmacology2012 - Present
American Institute of Biological Sciences, Peer Reviewed Medical Research Program09/2011 - 09/2011
Proceedings of the National Academy of Sciences2011 - Present
National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel: Review/Reverse Site Visit of ARC Grant Applications (P60), ZAA1 GG(92)07/2010 - 07/2010
Center for Scientific Review, RC4 Challenge Grants - Recovery Act Limited Competition: Director's Opportunity for Research in Five Thematic Areas, Stage 105/2010 - 05/2010
Pharmacology, Biochemistry and Behavior2010 - Present
Drug and Alcohol Dependence2010 - Present
National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel: Review of Alcohol Resource and Center Grant Supplement Applications, ZAA1 GG(01)09/2009 - 09/2009
National Institute on Alcohol Abuse and Alcoholism, NCI-ARRA P30 Biomedical Research Core Centers Review Committee, ZAA1 DD(02)07/2009 - 07/2009
Center for Scientific Review, Neurobiology of Motivated Behavior (NMB) Study Section06/2009 - 06/2009
Psychoneuroendocrinology2007 - Present
Journal of Medical Primatology2007 - Present
Journal of Medical Primatology2007 - Present
European Journal of Pharmacology2007 - Present
Child Development2006 - Present
Biochemical Pharmacology2006 - Present
City University of New York Internal Research Award Program11/2005 - 01/2006
Neuropsychopharmacology2005 - Present
Behavioural Brain Research2005 - Present
Alcoholism: Clinical and Experimental Research2005 - Present
National Center for Research Resources, Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities09/2004 - 06/2011
National Institute on Alcohol Abuse and Alcoholism, ZAA1 BB(12)06/2004 - 06/2004
Behavioural Pharmacology2004 - Present
European Journal of Pharmacology2003 - Present
Trends in Pharmacological Sciences2002 - Present
Psychopharmacology2002 - Present
Journal of Pharmacology & Experimental Therapeutics2000 - Present
Experimental & Clinical Psychopharmacology2000 - Present

Teaching Experience

NSCI 791, Graduate, Course, Course Director, Senior Laboratory RotationsSpring 2017
Medicine, Small Group, Facilitator, Tobacco & Inhalant UseFall 2017 - 2017
NSCI 791, Graduate, Course, Course Director, Senior Laboratory RotationsSummer 2017
NSCI 791, Graduate, Course, Course Director, Senior Laboratory RotationsFall 2017
NSCI 791, Graduate, Course, Course Director, Senior Laboratory RotationsSpring 2016
NSCI 791, Graduate, Course, Course Director, Senior Laboratory RotationsSummer 2016
NSCI 791, Graduate, Course, Course Director, Senior Laboratory RotationsFall 2016
NSCI 791, Graduate, Course, Course Director, Senior Laboratory RotationsSummer 2015
NSCI 791, Graduate, Course, Course Director, Senior Laboratory RotationsFall 2015
NSCI 719, Graduate, Course, Co-course Director, Critical Thinking & Analysis in NeuroscienceSpring 2014

Directed Student Learning

Supervised Research, Advised: Sean Patterson2017 - 2017
Internship Advisor, Advised: Ian Taylor2017 - Present
Dissertation Committee Member, Advised: Sydney Vita2017 - Present
Internship Advisor, Advised: John Overton2017 - Present
Dissertation Committee Member, Advised: Lindsey Kuiper2017 - Present
Dissertation Committee Member, Advised: Xiao Zhang2016 - Present
Internship Advisor, Advised: Jaren Reeves-Darby2015 - 2017
Doctoral Advisory Committee Member, Effects of nalfurafine on the abuse-related and antinociceptive effects of oxycodone in rats and rhesus monkeys
Advised: Edward Townsend		2014 - 2017
Doctoral Advisory Committee Chair, Advised: Cassie Chandler2014 - Present
Internship Advisor, Advised: Sherman Jones2014 - 2015
Doctoral Advisory Committee Member, The role of kruppel-like factor 11-monoamine oxidase (KLF11-MAO) pathway in ethanol-induced neurotoxicity and cell death: Evidence of neuroprotection by MAO inhibitors
Advised: Jeremy Duncan		2013 - 2015
Doctoral Advisory Committee Member, Evaluation of the anxiolytic-like, abuse-related, and sedative motor effects of benzodiazepine and neuroactive steroid combinations in rats
Advised: Barak Gunter		2013 - 2015
Master's Thesis Committee Chair, Relationship between performance on a novel object recognition test and relative expression of glucose transporters GLUT1 and GLUT3 in rhesus macaques: Support for the insulin resistance hypothesis of diabetes-induced cognitive deficits?
Advised: Shana Langer		2013 - 2015
Postdoctoral mentor, Advised: Eileen Sawyer2012 - 2013
Internship Advisor, Advised: Nicholas Porter2011 - 2012
Internship Advisor, Advised: Kevin Liang2011 - 2012
Internship Advisor, Advised: Lisa Goldberg2010 - 2011
Internship Advisor, Advised: Eileen Curran2009 - 2010
Postdoctoral Mentor, Advised: Daniela Ruedi-Bettschen2006 - 2007

Residency Training

Office of Medical Student & Resident Research, Research Advisor2017 - Present