Yi Pang, PhD
Associate Professor
Department:
SOM-Peds-Neonatology
Email:
ypang@umc.edu
Work Phone:
(601) 984-2786
Biography
Dr. Pang obtained his MD from LanZhou Medical College in 1992 and his PhD from the Chinese Academy of Medical Sciences in 1998. After completing his postdoctoral training in 2001, he joined the Department of Pediatrics, University of Mississippi Medical Center as a faculty member. With over 25 years of dedicated research in the developmental neuroscience field, Dr. Pang’s pioneering work in undercovering molecular mechanisms of oligodendrocyte development and myelination impairments in animal models has significantly advanced our understanding of Brain White Matter Injury, a devastating condition affecting millions of very premature infants. His reputation as a leading scholar in the field is evidenced by more than 65 publications with over 5,400 citations.
Dr. Pang is actively engaged in serving the scientific community. He serves on the editorial boards of three scientific journals. He has participated in ad hoc reviews of manuscripts for more than 30 neuroscience journals and grant applications for private and government agencies such as Parkinson UK, the French MS Research Society, the March of Dimes, and the Department of Defense (DOD). In addition to his research, Dr. Pang is deeply committed to the education mission of the Medical Center. He has trained and mentored many undergraduate, graduate, and postgraduate (neonatal fellows) students.
Education
| Chinese Academy of Medical Sciences, PhD, Pathophysiology | 1998 |
| Kunming Medical college, MS, Pathophysiology | 1995 |
| LanZhou Medical college, MD, Medicine | 1992 |
Current Positions
| Associate Professor, School of Medicine, Department of Pediatrics | 07/2017 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Pediatrics | 07/2004 - 06/2017 |
| Instructor, University of Mississippi Medical Center, School of Medicine | 07/2001 - 06/2004 |
Sponsored Program Funding
| Intramural, (Mentor) A novel animal model of diffuse white matter injury, Department of Pediatrics | 04/2021 - 03/2022 |
| Extramural, (Co-investigator) Mechanisms of blast-induced vestibular injury, NIH-NIDCD | 09/2020 - 08/2025 |
| Intramural, (Mentor)Innovative, reproducible, and clinically relevant mouse model of white matter damage in very low birth infants, Agent: Intradepartmental Discovery Support Program (IDOG) | 07/2019 - 06/2020 |
| Extramural, (Pilot project PI)Maternal immune activation disrupts neurodevelopment: role of microglia, NIH/MS CREB (COBRE) | 10/2018 - 12/2019 |
| Intramural, (PI) Placental mechanisms of neurodevelopmental impairments in Autism Spectrum Disorder, Department of Pediatrics, University of Mississippi Medical Center | 07/2018 - 06/2019 |
| Extramural, (Co-investigator) Astrocyte gap junctions, myelin integrity and depression-like behaviors, NIH/NIMH | 07/2017 - 06/2018 |
| Extramural, (Consultant) Hyperandrogenemia and Depression: Role of Proinflammatory Cytokines, NIH/MS PIN (COBRE) | 01/2017 - 07/2018 |
| Intramural, (Mentor) Macrolides and LPS-induced inflammatory brain injury mediated by microglia, Intradepartmental Discovery Support Program (IDOG) | 07/2016 - 08/2017 |
| Extramural, (PI) Exploring a novel neurotrophic factor to protect nigrostriatal dopaminergic neurons and alleviate motor deficits in an animal model of Parkinson's disease, Michael J Fox foundation | 01/2014 - 11/2016 |
| Intramural, (PI) Hyperoxia, inflammation, and white matter damage, UMMC Intramural Research Support Program (IRSP) | 11/2013 - 10/2014 |
| Extramural, (co-investigator) Early life brain inflammation and vulnerability to neurodegeneration in late life, NIH/NINDS | 07/2013 - 03/2018 |
| Extramural, (co-investigator) Perinatal infection, cytokines and brain injury, NIH/NINDS | 07/2011 - 06/2012 |
| Extramural, (co-investigator) Serotonin, Corpus Callosum, and Autism, NIH/NIMH | 07/2008 - 04/2012 |
| Extramural, (co-investigator) Perinatal infection, Cytokines and brain injury, NIH/NICHD | 07/2005 - 06/2012 |
| Intramural, (PI) Effect of TNF-alpha on the development of oligodendrocytes, UMMC/Department of Pediatrics | 06/2003 - 05/2004 |
| Extramural, (co-investigator) Perinatal hypoxia-ischemia, glutamate receptors and NOS, NIH/NICDH | 05/2003 - 06/2010 |
Publications
Journal Article | |
| Loayza1 M, Lin S, Carter K, Ojeda N, Fan LW, Ramarao S, Bhatt A*, Pang Y*. Maternal immune activation alters fetal and neonatal microglia phenotype and disrupts neurogenesis in mice. Pediatric Research 2023; 93(5):1216-1225 | 2023 |
| Ramarao S, Pang Y*, Carter K, Bhatt A*. Azithromycin Protects Oligodendrocyte Progenitor Cells against Lipopolysaccharide-activated Microglia-induced damage Dev Neurosci 2021;Sep 22021 Sep 27. doi: 10.1159/000519874. Online ahead of print. | 2021 |
| Ou Y, Clifton BA, Li JH, Sandlin D, Li N, Wu L, Zhang CM, Chen TW, Huang J, Yu Y, Allison J, Fan F, Roman RJ, Shaffery J, Zhou W, Pang Y*, Zhu H*. Traumatic brain injury induced by exposure to blast overpressure via ear canal. Neural Regeneration Research 2022 Jan;17(1):115-121. doi: 10.4103/1673-5374.314311. | 2021 |
| Rains, ME, Muncie, CB, Pang Y, Fan LW, Tien LT, Ojeda NB. Oxidative Stress and Neurodevelopmental Outcomes in Rats Offspring with Intrauterine Growth Restriction Induced by Reduced Uterine Perfusion. Brain Sci. 2021, 11, 78. | 2021 |
| Yu Y, Huang J, Tang X, Allison J, Sandlin D, Ding D, Pang Y, Zhang C, Chen T, Yin N, Chen L, Mustain W, Zhou W, Zhu H. Exposure to blast shock waves via the ear canal induces deficits in vestibular afferent function in rats. J Otol. 2020 Sep;15(3):77-85. doi: 10.1016/j.joto.2020.01.003. Epub 2020 Jan 22. | 2020 |
| Miguel-Hidalgo J, Carter K, Deloach P, Sanders L, Pang Y. Glucocorticoid-induced reductions of myelination and connexin 43 in mixed central nervous system cell cultures are prevented by mifepristone. Neuroscience. 2019; 411:255-269. | 2019 |
| Narang R, Carter K, Muncie C, Pang Y, Fan LW, Feng Y, Ojeda NB, Bhatt AJ. Intrauterine growth restriction and neonatal hypoxic ischemic brain injury causes sex-specific long-term neurobehavioral abnormalities in rats. J Neurosci Res. 2019;7. doi: 10.1002/jnr.24389. | 2019 |
| Fan LW, Carter K, Bhatt A, Pang Y. Rapid transport of insulin to the brain following intranasal administration in rats. Neural regeneration research. 2019; 14(6):1046-1051. | 2019 |
| Tien LT, Lee YJ, Pang Y, Lu S, Lee JW, Tseng CH, Bhatt AJ, Savich RD, Fan LW. Neuroprotective effects of intranasal IGF-1 against neonatal lipopolysaccharide-induced neurobehavioral deficits and neuronal inflammation in the substantia nigra and locus coeruleus of juvenile rats. Dev Neuroscience 2017;39:443-459 | 2017 |
| Yi Pang, Xuemei Dai, Anna Roller, Kathleen Carter, Ian Paul, Abhay J. Bhatt, Rick C.S. Lin, Lir-Wan Fan Early postnatal lipopolysaccharide exposure leads to enhanced neurogenesis and impaired communicative functions in rats PLoS ONE 2016; 11(10): e0164403. doi:10.1371/journal.pone.0164403 | 2016 |
| Pang Y, Lin S, Wright C, Shen J, Carter K, Bhatt A, Fan LW Intranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in rats Neuroscience. 2016; 318:157-65. | 2016 |
| Lan KM, Tien LT, Cai Z, Lin S, Pang Y, Tanaka S, Rhodes PG, Bhatt AJ, Savich RD, Fan LW. Erythropoietin ameliorates neonatal hypoxia-ischemia-induced neurobehavioral deficits, neuroinflammation, and hippocampal injury in the juvenile rat Int J Mol Sci 2016;17:(3). doi:10.3390/ijms17030289. | 2016 |
| Fan LW, Bhatt A, Tien LT, Zheng B, Simpson K, Cai Z, Lin R, Kumar P, Pang Y Exposure to serotonin adversely affects oligodendrocyte development and myelination in vitro Journal of Neurochemistry 2015;133(4):532-43 | 2015 |
| Lan KM, Tien LT, Pang Y, Bhatt AJ, Fan LW IL-1 receptor antagonist attenuates neonatal lipopolysaccharide-induced long-lasting learning impairment and hippocampal injury in adult rats Toxicol Lett. 2015; 234: 30-9 | 2015 |
| Pang Y, Tien LT, Zhu H, Shen J, Wright CF, Jones TK, Mamoon SA, Bhatt AJ, Cai Z, Fan LW. Interleukin-1 receptor antagonist reduces neonatal lipopolysaccharide-induced long-lasting neurobehavioral deficits and dopaminergic neuronal injury in adult rats. Int J Mol Sci. 2015; 16(4):8635-54. doi: 10.3390/ijms16048635. | 2015 |
| Bhatt A, Fan LW, Pang Y Strategies for myelin regeneration, lessons learned from development. Neural Regen Res 2014;9:1347-1350 (invited review) | 2014 |
| Pang Y, Fan LW, Tien LT, Dai X, Zheng B, Cai Z, Lin R, Bhatt A Differential roles of astrocyte and microglia in supporting oligodendrocyte development and myelination in vitro Brain and Behavior 2013. 3:503-514 | 2013 |
| Kaizaki A, Tien LT, Pang Y, Cai Z, Tanaka S, Numazawa S, Bhatt AJ, Fan LW Celecoxib reduces brain dopaminergic neuronal dysfunction, and improves sensorimotor behavioral performance in neonatal rats exposed to systemic lipopolysaccharide J Neuroinflammation 2013;10:45. | 2013 |
| Wang K, Fan LW, Kaizaki A, Pang Y, Cai Z, Tien LT. Neonatal lipopolysaccharide exposure induces long-lasting learning impairment, less anxiety-like response and hippocampal injury in adult rats Neuroscience; 2013;234:146-157 | 2013 |
| Cai Z, Fan LW, Kaizaki A, Tien LT, Ma T, Pang Y, Lin S, Lin R, Simpson K Neonatal systemic exposure to lipopolysaccharide enhances susceptibility of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in late life Dev Neuroscience. 2013;35:155-171 | 2013 |
| Fan LW, Kaizaki A, Tien LT, Pang Y, Tanaka S, Numazawa S, Bhatt AJ, Cai Z Celecoxib attenuates systemic lipopolysaccharide-induced brain inflammation and white matter injury in the neonatal rats Neuroscience 2013; 240:27-38 | 2013 |
| Tien LT, Kaizaki A, Pang Y, Cai Z, Bhatt A, Fan LW Neonatal exposure to lipopolysaccharide enhances accumulation of alpha-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in response to rotenone challenge in late life. Toxicology 2013; 308:96-103 | 2013 |
| Campbell LR, Pang Y, Ojeda NB, Zheng B, Rhodes PG, Alexander BT Intracerebral lipopolysaccharide induces neuroinflammatory change and augmented brain injury in growth-restricted neonatal rats. Pediatr Res. 2012;71:645-52. | 2012 |
| Pang Y, Fan LW, Zheng B, Campbell LR, Cai Z, Rhodes PG. Dexamethasone and betamethasone protect against lipopolysaccharide-induced brain damage in neonatal rats. Pediatr Res 2012;71:552-8 | 2012 |
| Pang Y, Zheng B, Kimberly SL, Cai Z, Rhodes PG, Lin RC. Neuron-oligodendrocyte myelination co-culture derived from embryonic rat spinal cord and cerebral cortex. Brain Behav. 2012;2:53-67. | 2012 |
| Simpson KL, Weaver KJ, de Villers-Sidani E, Lu JY, Cai Z, Pang Y, Rodriguez-Porcel F, Paul IA, Merzenich M, Lin RC Perinatal antidepressant exposure alters cortical network function in rodents. Proc Natl Acad Sci U S A. 2011;108:18465-70. | 2011 |
| Cai Z, Fan LW, Lin S, Pang Y, Rhodes PG Intranasal administration of insulin-like growth factor-1 protects against lipopolysaccharide-induced injury in the developing rat brain. Neuroscience. 2011;194:195-207. | 2011 |
| Fan LW, Tien LT, Zheng BY, Pang Y, Lin R, Simpson K, Ma T, Rhodes P, and Cai Z Dopaminergic neuronal injury in the adult rat brain following neonatal exposure to lipopolysaccharide and the silent neurotoxicity. Brain Behav Immun. 2011 Feb;25(2):286-97. | 2011 |
| Pang Y, Zheng B, Campbell L, Fan L, Cai Z and Rhodes P. IGF-1 can either protect against or increase LPS-induced damage in the developing rat brain Pediatric Res 2010; 67:579-84. | 2010 |
| Fan LW, Tien LT, Zheng B, Pang Y, Rhodes PG, Cai Z Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitrone. Neuroscience. 2010. 168: 240-252 | 2010 |
| Pang Y, Campbell L, Zheng B, Fan L, Cai Z, Rhodes P. LPS-activated microglia induce death of oligodendrocyte progenitor cells and impede their development Neuroscience. 2010; 166:464-475. | 2010 |
| Fan LW, Mitchell HJ, Tien LT, Zheng B, Pang Y, Rhodes, Cai Z alpha-phenl-n-tert-butyl-nitrone reduces lipopolysaccharide-induced white matter injury in the neonatal rat brain Dev Neurobio. 2008; 68:365-78 | 2008 |
| Pang Y, Zheng B, Fan LW, Rhodes PG, Cai Z. IGF-1 protects oligodendrocyte progenitors against TNF-alpha-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway Glia. 2007; 55:1099-1107. | 2007 |
| Fan LW, Lin S, Pang Y, Rhodes PG, Cai Z. Minocycline attenuates hypoxia-ischemia-induced neurological dysfunction and brain injury in the juvenile rat. Eur J Neurosci. 2006;24:341-50 | 2006 |
| Cai Z, Lin S, Fan LW., Pang Y, Rhodes PG Minocycline alleviates hypoxic-ischemic injury to developing oligodendrocytes in the neonatal rat brain. Neuroscience. 2006; 137:425-435 | 2006 |
| Pang Y, Fan LW., Zheng BY, Cai ZW, Rhodes PG Role of Interleukin-6 in lipopolysaccharide-induced brain injury and behavioral dysfunction in neonatal rats Neuroscience. 2006; 141:745-755 | 2006 |
| Fan LW, Lin S, Pang Y, Lei M, Zhang F, Rhodes PG, Cai Z. Hypoxia-ischemia induced neurological dysfunction and brain injury in the neonatal rat. Behav Brain Res. 2005;165:80-90. | 2005 |
| Pang Y, Cai Z and Rhodes PG. Effect of TNF-alpha on developing optic nerve oligodendrocyte in culture. J Neurosci Res. 2005;80 :226-234 | 2005 |
| Lin S, Fan LW, Pang Y, Rhodes PG., Mitchell HJ., Cai Z. IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal rat. Brain Res 2005; 1063:15-26. | 2005 |
| Fan LW, Pang Y, Lin S, Rhodes PG, Cai Z. Minocycline attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain. Neuroscience. 2005; 133:159-168. | 2005 |
| Fan LW, Pang Y, Lin S, Tie LT, Ma TG, Rhodes PG and Cai Z. Minocycline reduces lipopolysaccharide-induced neurological dysfunction and brain injury in the neonatal rat. J Neurosci Res.2005; 82:71-82 | 2005 |
| Pang Y, Rodts-Palenik S, Cai Z, Bennett WA., Rhodes P.G. Suppression of glial activation is involved in the protection of IL-10 on maternal E.coli induced neonatal white matter injury. Dev. Brain Res. 2005; 157:141-149 | 2005 |
| Cai ZW, Lin S, Pang Y and Rhodes PG. Brain Injury Induced by Intracerebral Injection of Interleukin-1beta and Tumor Necrosis Factor-alpha in the Neonatal Rat. Pediatr Res. 2004; 56: 377-384 | 2004 |
| Rodts-Palenik S, Wyatt-Ashmead J, Pang Y, Thigpen B, Cai Z, Rhodes P, Martin JN, Granger J, Bennett WA. Maternal infection-induced white matter injury is reduced by treatment with interleukin-10. Am J Obstet Gynecol. 2004; 191:1387-92 | 2004 |
| Pang Y, Cai ZW, Rhodes PG. Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide. Brain Res Dev Brain Res. 2003; 140; 205-214 | 2003 |
| Cai ZW, Pang Y, Lin S, Rhodes PG. Differential roles of tumor necrosis factor-alpha and interleukin-1 beta in lipopolysaccharide-induced brain injury in the neonatal rat. Brain Res. 2003; 975 :37-47. | 2003 |
| Zhang F, Liu H, Stile F, Lei MP, Pang Y, Oswald TM, Beck J, Dorsett-Martin W, Lineaweaver WC. Effect of vascular endothelial growth factor on rat Achilles tendon healing. Plast Reconstr Surg. 2003;112:1613-9. | 2003 |
| Pang Y, Lineaweaver WC, Lei MP, Oswald T, Shamburger S, Cai Z, Zhang F. Evaluation of the mechanism of vascular endothelial growth factor improvement of ischemic flap survival in rats. Plast Reconstr Surg. 2003; 112:556-64. | 2003 |
| Zhang F, Lei MP, Oswald TM, Pang Y, Blain B, Cai ZW, Lineaweaver WC The effect of vascular endothelial growth factor on the healing of ischaemic skin wounds. Br J Plast Surg. 2003; 56:334-41 | 2003 |
| Zhang F, Pang Y, Buntic RF, Jones M, Cai Z, Buncke HJ, Lineaweaver WC. The Effect of Sequence, Timing of Vascular Anastomosis, and Clamp Removal on Survival of Microsurgical Flaps. J Reconstr Microsurg. 2002; 18:697-701. | 2002 |
| Pang Y, Cai ZW, Rhodes PG. Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arrays. Brain Res. 2001; 914:15-22 | 2001 |
| Cai ZW, Pang Y, Xiao F, and Rhodes PG. Chronic ischemia preferentially causes white matter injury in the neonatal rat brain. Brain Res. 2001; 898:126-35 | 2001 |
| Pang Y, Cai ZW, Rhodes PG. Effects of lipopolysaccharide on oligodendrocyte progenitor cells are mediated by astrocytes and microglia. J Neurosci Res. 2000; 62:510-520 | 2000 |
| Pang Y, Xu S, Xue Q Effect of Oxidized LDL, Hypoxia and 5-hydroxytraptamin on 5-HT2A receptor and Intracellular Free Calcium in Cultured Smooth Muscle Cells Zhongguo Yi Xue Ke Xue Yuan Xue Bao (Acta Academiae Medicinae Sinicae). 2000; 22:20-24. (Article in Chinese, abstract in English) | 2000 |
| Cai ZW, Pan ZL, Pang Y, Evans OB, and Rhodes PG. Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatric Res. 2000; 47:64-72 | 2000 |
| Pang Y, Li Lin-Xian, Wang Zi-Can. Monoamines and ischemic brain damage Journal of Kunming Medical College 1999;20(1):63-66. (Article in Chinese). | 1999 |
| Pang Y, Li Lin-Xian, Wang Zi-Can The neuroprotective effects of dextromethorphan on experimental cerebral ischemia Chinese Journal of Pathophysiology. 1999, 15(4):315-317 (Article in Chinese). | 1999 |
| Pang Y, Xu S, Xue Q. Study of platelet 5-HT2A receptor in patients suffer from coronary artery disease Basic Medical Sciences and Clinics. 1998;18:38-42. (Article in Chinese) | 1998 |
| Yang L, Lin S, Pang Y, Nan J, Xue S. Changes of 5-HT2A receptor binding on platelet of patients with CAD and the effects of exercise test. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1997;19:337-41. (abstract in English | 1997 |
| Loayza1 M, Lin S, Carter K, Ojeda N, Fan LW, Ramarao S, Bhatt A*, Pang Y* Maternal immune activation alters fetal and neonatal microglia phenotype and disrupts neurogenesis in mice Pediatric Research 2023; 93(5):1216-1225 | |
| Loayza1 M, Lin S, Carter K, Ojeda N, Fan LW, Ramarao S, Bhatt A*, Pang Y*. Maternal immune activation alters fetal and neonatal microglia phenotype and disrupts neurogenesis in mice. Pediatric Research 2023; 93(5):1216-1225 | |
Review Article | |
| Miguel-Hidalgo J, Pang Y. Role of neuroinflammation in establishing neurogenic microenvironment in brain diseases. Current Tissue Microenvironment Reports. 2021 (Invited review, submitted). | 2021 |
| Lu SL, Tien LT, Tu YC, Pang Y, Fan LW Mucus Secretion and Calcium Mobilization in Airway Submucosal Gland Cell FJJM. 2017;15:45-57. DOI: 10.3966/181020932017031501007. | 2017 |
| Fan LW, Pang Y. Dysregulation of neurogenesis by neuroinflammation: key differences in neurodevelopmental and neurological disorders. Neural Regen Res. 2017;12:366-71 | 2017 |
| Lu S, Shaffery JP, Pang Y, Tien LT, Fan LW. Rapid Eye Movement Sleep Homeostatic Response: A Potential Marker for Early Detection of Parkinson’s Disease J Alzheimers Dis Parkinsonism 2016, 6:4. DOI: 10.4172/2161-0460.1000255 | 2016 |
| Pang Y, Xu S Dysregulation of serotonin 2A receptor signaling in cardiovascular disease Foreign Medical Sciences (Geriatrics) 1998 (04):152-158 | 1998 |
Book Chapter | |
| Miguel-Hidalgo J.J., Pang Y*. Myelination In: Pfaff D.W., Volkow N.D., Rubenstein J. (eds) Neuroscience in the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6434-1_178-1 | 2022 |
| Pang Y*, Simpson K., Miguel-Hidalgo J.J., Savich R. Neuron/Oligodendrocyte Myelination Coculture. In: Woodhoo A. (eds) Myelin. Methods in Molecular Biology. 2018, vol 1791. Humana Press, New York, NY. DOI. https://doi.org/10.1007/978-1-4939-7862-5_10. | 2018 |
| Kalikkot R, Bhatt A, Ramarao S, Cai Z, Pang Y*. Combined therapy of hypothermia for hypoxic encephalopathy in neonates. In “Frontiers in clinical drug research-CNS and Neurological Disorders”. Bentham Science Publishers. 2018. Chapter 6. P35-71. | 2018 |
| Simpson K, Pang Y, Lin R. Multi-facet application with light and electron microscopic approaches to study abnormal circuitry maturation in the rodent models Invited book chapter, Neuromethods. 2015: 1-14. Published by Springer Science. DOI: 10.1007/7657_2015_80 | 2015 |
Presentations
| Platform Presentations, Spatiotemporal distribution of insulin following intranasal application in rats, 37th Southern Biomedical Engineering Conference, New Orleans, LA | 12/2021 |
| Regional Invited Seminars/Lectures, Role of neuroinflammation in neurological disorders, Department of Neurology, UMMC | 06/2021 |
| Platform Presentations, A NOVEL RAT MODEL OF INFLAMMATION DRIVEN DIFFUSE WHITE MATTER INJURY, 2021 Virtual Western Medical Research Conference | 01/2021 |
| Platform Presentations, Maternal immune activation promotes aberrant neural growth in offspring rats, Southern Biomedical Engineering Conference, New Orleans, LA | 03/2020 |
| Poster Presentation, Maternal immune challenge enhances neural progenitor cell proliferation and increases hippocampal volume in neonatal rats., Society for Neuroscience, Chicago, IL. | 11/2019 |
| Poster Presentation, Reductions of Myelination and Connexin 43 by Glucocorticoids Are Prevented by Mifepristone in Mixed Central Nervous System Cell Cultures. Annual meeting of Biological Psychiatry, Annual Meeting of Biological Psychiatry, Chicago, IL | 05/2019 |
| Poster Presentation, Brain insulin distribution in rats following intranasal application., Society for Neuroscience, San Diego, CA | 11/2018 |
| Poster Presentation, Early postnatal lipopolysaccharide exposure leads to enhanced neurogenesis and impaired communicative functions in rats. . program number: 294.04, Society for Neuroscience, San Diego, CA | 11/2016 |
| Poster Presentation, Intranasal insulin protects against 6-OHDA-induced dopaminergic neuron loss in the substantia nigra and alleviates motor behavioral deficits in rats., Society for Neuroscience, Chicago, IL. | 11/2015 |
| State/Local Invited Seminars/Lectures, Early life infection, brain development and behavior, University of Mississippi, Research day 3 minutes lecture, Oxford, MS | 05/2015 |
| Regional Invited Seminars/Lectures, Microglia on oligodendrocyte development: friends or foes?, Department of Psychiatry and Human behavior, University of Mississippi Medical Center, Jackson, MS | 11/2014 |
| Poster Presentation, Hyperoxia activates microglia but reduces apoptosis in the neonatal rat brain, SFN, Washington, DC | 11/2014 |
| Regional Invited Seminars/Lectures, Microglia: the good, the bad, and the ugly, Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center. Jackson, MS. | 09/2014 |
| Platform Presentations, The role of microglia in myelination: a friend or a foe?, Pediatric Academic Society Annual Meeting, Vancouver, Canada | 05/2014 |
| Poster Presentation, Do microglia play a role in myelination during development?, Society for Neuroscience (SFN), San Diego | 11/2013 |
| Regional Invited Seminars/Lectures, Neurological consequences of early life infection/inflammation, UMMC Dept. of Pediatrics, Jackson, MS | 04/2013 |
| Poster Presentation, Sex-specific effect of serotonin on cortical neuron development in vitro, Society for Neuroscience (SFN), New Orleans, LA | 10/2012 |
| Poster Presentation, Dissociated oligodendrocyte-neuron co-cultures from embryonic rat CNS tissue: an improved in vitro myelination model, Society for Neuroscience (SFN), Washington, DC | 10/2011 |
| Poster Presentation, IGF-1 can either protect against or increase LPS-induced damage in the developing rat brain, Pediatric Academy Society Annual Meeting, Vancouver, Canada | 05/2010 |
| Poster Presentation, Dexamethasone and betamethasone protect against LPS-induced white matter damage and behavioral deficits in neonatal rats., Society for Neuroscience (SFN), Chicago, IL | 2009 |
| Poster Presentation, Activated microglia induces oligodendrocyte progenitor cell death through two phases: an acute damage mediated by nitric oxide and a delayed injury by cytokines., Society of Neuroscience (SFN), Washington, DC | 2008 |
| Poster Presentation, Differential expression of anti-apoptotic proteins during oligodendrocyte maturation, Society for Neuroscience (SFN), San Diego, CA | 2007 |
| Poster Presentation, IGF-1 protects TNF-alpha-induced oligodendrocyte progenitor damage through Akt/cFLIP., Society for Neuroscience (SFN), Atlanta, GA | 2006 |
| Regional Invited Seminars/Lectures, Effects of TNF-alpha on the developing oligodendrocyte, UMMC Dept. of Pediatrics, Jackson, MS | 02/2004 |
| Poster Presentation, Mechanisms involved in the protective effect of IGF-1 on TNF-α induced oligodendrocyte progenitor injury., Society for Neuroscience, San Diego, CA | 2004 |
| Poster Presentation, Anti-inflammatory mechanism of protective effect of IL-10 following inflammatory insult to fetal rat brains via uterine injection of E. coli to pregnant rats., Society for Neuroscience (SFN), New Orleans, LA | 2003 |
| Poster Presentation, Differential vulnerability of oligodendrocyte to TNF-alpha cytotoxicity., Society for Neuroscience (SFN), Orlando, FL | 2002 |
| Poster Presentation, Periventricular leukomalacia-like brain injury induced by intracerebral injection of lipopolysaccharide in the neonatal rat brain., Society for Neuroscience (SFN), San Diego, CA | 2001 |
Honors, Awards, and Recognition
| Ad hoc grant review, Discovery Research Grant Request for Application, March of Dimes, Preterm Birth Panel | 2024 |
| Ad hoc grant review, Congressionally Directed Medical Research Programs, DOD, Trauma Immunology review panel | 2024 |
| Neuroscience Session Co-Chair, Southern Biomedical Engineering Conference | 2023 |
| Ad hoc review, grant application, Congressionally Directed Medical Research Programs (CDMPR), Department of Defense, Parkinson's Research Program Treatment and Therapy TT Pannel | 2022 |
| Ad hoc reviewer, U.S. Army Medical Research and Materiel Command (USAMRDC) Broad Agency Announcement, Chemical, Biological, Radiological and Nuclear (CBRN) Review panel | 2022 |
| Neuroscience Session Chair, Southern Biomedical Engineering Conference | 2021 |
| Ad hoc grant reviewer, Peer Reviewed Medical Research Program (PRMPR) – Sleep Disorder and Restriction Discovery Award review panel. Department of Defense | 2021 |
| Ad hoc grant reviewer, Peer Reviewed Medical Research Program (PRMRP) Pre-application – Sleep Disorders and Restriction pre-application peer review panel. Department of Defense | 2021 |
| Ad hoc grant reviewer, ARSEP Foundation, French Multiple Sclerosis Research Society | 2020 |
| Top 10% of most cited PLoS One authors of 2016, PloS One | 2020 |
| Neuroscience session chair, Southern Biomedical Engineering Conference | 2020 |
| Scientific co-chair, Annual Meeting of ISCM, International Society for Ceramic | 2019 |
| Ad hoc grant reviewer, Parkionson UK | 2018 |
| Ad hoc grant reviewer, Parkionson UK | 2016 |
| Cover Image, Journal of Neurochemistry 2015;133(4):532-43 | 2015 |
| Research Highlight, UMMC publication CenterView, Nov. 2013 | 2013 |
| 2013 SFN poster highlight, Simons Foundation | 2013 |
| Award Tenure, UMMC | 2007 |
| Outstanding graduate student of the year, 1998, Chinese Academy of Medical Sciences | 1997 |
Professional Membership and Service
| International Society for Neurochemistry, Member, Membership since 2013 | 2013 - Present |
| Program in Neuroscience (PIN), Member, Faculty in the Neuroscience Program since 2010 to present | 2010 - Present |
| Society for Neuroscience, Member, Membership since 2000 | 2000 - Present |
Committee Service
| Program committee member and Scientific chair, 37th Southern Biomedical Engineering Conference, New Orleans, LA, Member | 2021 - 2021 |
| SCHOOL OF MEDICINE-ADMISSIONS FILE REVIEW SUBCOMMITTEE, Member | 2021 - Present |
| Pediatric Faculty Development Advisory Committee, Member | 2020 - Present |
| Program committee member and Scientific chair, 36th Southern Biomedical Engineering Conference, New Orleans, LA, Member | 2020 - 2020 |
| NICU Research Subcommittee, Member | 2020 - Present |
| Program committee member and Scientific co-chair, 31th annual meeting of International Society of Ceramics in Medicine (ISCM), New Orleans, LA, Co-Chair | 2019 - 2019 |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-MD/PHD ADVISORY, Member | 2015 - 2019 |
Community Service
| Pediatric Research Day Presentation, Judge | 07/2024 - Present |
| SHRP Research Day, Poster Judge | 04/2021 - Present |
| 84th annual meeting, Mississippi Academy of Science, Judge | 02/2020 - 02/2020 |
| Mississippi Alliance to End Suicide (Madison, MS), Volunteer, fundraiser | 07/2019 - 07/2019 |
| Chinese Culture Spring Festival 2016 (Jackson, Mississippi), volunteer | 02/2019 - 02/2019 |
| High school science fair, Hartfield Academy, Brandon, MS, judge | 05/2018 - Present |
| Chinese Culture Spring Festival 2016 (Jackson, Mississippi), volunteer | 02/2018 - 02/2018 |
| Chinese Culture Spring Festival 2016 (Jackson, Mississippi), volunteer | 01/2016 - Present |
| 2015 Delta Dragon Boat Festival Gala (Greenville, Mississippi), Volunteer | 07/2015 - Present |
| Tase of U (UMMC), Volunteer | 02/2014 - Present |
Other Service
| Brain Sciences | 07/2024 - Present |
| Neural Regeneration Research (reviewer) | 12/2021 - 12/2021 |
| Neuropharmacology (Reviewer) | 05/2021 - 05/2021 |
| Brain Research (Reviewer) | 04/2021 - 04/2021 |
| Judge, The school of Health Related Professions 2021 Research Day | 04/2021 - 04/2021 |
| Immuno (Editorial Board) | 04/2021 - Present |
| Meeting manuscript judge, 58th Annual Rocky Mountain Bioengineering Symposium, Virtual (Referee) | 04/2021 - 04/2021 |
| Neural Regeneration Research (reviewer) | 09/2020 - Present |
| Acta Biomateria (reviewer) | 06/2020 - 07/2020 |
| Neonatology and Clinical Pediatrics (reviewer) | 05/2020 - Present |
| Molecular Neurobiology (reviewer) | 05/2020 - 05/2020 |
| Neuroregeneration Research (reviewer) | 03/2020 - 03/2020 |
| J Alzheimei's Disease (reviewer) | 07/2019 - 08/2019 |
| Neuroscience Letter (reviewer) | 04/2019 - 05/2019 |
| Neural Regeneration Research (reviewer) | 05/2018 - Present |
| Molecular Neuroscience (reviewer) | 01/2018 - 04/2018 |
| Brain Behav Immune (reviewer) | 07/2017 - Present |
| Scientific Report (reviewer) | 06/2017 - Present |
| Review, 2017 Pediatric Academic Societies Meeting | 01/2017 - 01/2017 |
| Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) (reviewer) | 11/2016 - 11/2016 |
| Brain Research (reviewer) | 10/2016 - Present |
| Biomedicine and Pharmacotherapy (reviewer) | 10/2016 - 10/2016 |
| Grant review: Parkionson's UK | 08/2016 - Present |
| International Journal of Develpmental Neuroscience (reviewer) | 2016 - Present |
| Neurotoxicity Research (reviewer) | 2016 - Present |
| Neural Regeneration Research (reviewer) | 2016 - Present |
| Journal of Neonatology and Clinical Pediatrics (Section Editor) | 2015 - Present |
| Int Dev Neurosci (reviewer) | 2015 - Present |
| Int Integrative Pediatrics and Envionmental Medicine (editorial board member) | 2015 - Present |
| ScienceOpen Research (reviewer) | 2015 - Present |
| Int J Mol Sci (reviewer) | 2015 - Present |
| Pediatric Research (reviewer) | 05/2014 - Present |
| Eur J Neurosci (reviewer) | 2014 - Present |
| Food and Function (reviewer) | 2014 - Present |
| Int J Dev Neurosci (reviewer) | 2014 - Present |
| Int J Bio Sci (Reviewer) | 2014 - Present |
| Life Science (reviewer) | 2014 - Present |
| Pediatric Research (reviewer) | 2014 - Present |
| PlosOne (reviewer) | 2014 - Present |
| Neural Regeneration Research (Editorial Board Member) | 2014 - Present |
| Discovery Council, Department of Pediatrics (Grant review), member | 2014 - 01/2014 |
| Eur J Pharm (reviewer) | 2013 - Present |
| Pediatric Res (reviewer) | 2013 - Present |
| Dev Neurosci (reviewer) | 2012 - Present |
| Neuroscience (reviewer) | 2012 - Present |
| Manuscript reviewer (Neuroregeneration Research) |
Teaching Experience
| 615, Medicine, Lab, Lab Presenter, Medical Neurobiology (615) | Spring 2014 |
| 701, Graduate, Lecture, Lecturer, Dev Neuroscience (NSI 701) | Spring 2014 |
| 615, Medicine, Small Group, Lab Presenter, Medical Neurobiology (615) | Spring 2013 |
| 704, Graduate, Lecture, Lecturer, Dev Neuroscience (NSCI 704) | Spring 2013 |
| 704, Graduate, Lecture, Lecturer, Dev Neuroscience (NSCI 704) | Spring 2012 |
| 704, Graduate, Lecture, Lecturer, Dev Neuroscience (NSCI 704) | Spring 2011 |
Directed Student Learning
| Internship Advisor, Advised: Catherine Zhou | 2024 - 2024 |
| Dissertation Committee Member, Advised: Gena Mazique | 2023 - Present |
| Internship Advisor, Advised: Aaron Hayes | 2023 - 2023 |
| Supervised Research, Advised: Madeline Griffin | 2022 - 2022 |
| Supervised Research, Advised: Sarah Boone | 2022 - 2022 |
| Internship Advisor, Advised: May Hebert | 2022 - 2022 |
| Internship Advisor, Advised: Tina Truong | 2021 - 2021 |
| Supervised Research, Advised: Joseph Araujo | 2014 - 2015 |
Fellows supervised
| Neonatology fellowship, Research Advisor, 1 fellows supervised | 07/2019 - Present |
| Neonatology fellowship, Research Advisor, 1 fellows supervised | 07/2017 - 06/2020 |
| Neonatology fellowship, Research Advisor, 1 fellows supervised | 07/2016 - 06/2019 |
| Neonatology fellowship, Research Advisor, 1 fellows supervised, Independent original research | 07/2009 - 06/2011 |