Patrick B. Kyle

Patrick B. Kyle

Professor

Department:
SOM-Pathology

Email:
pkyle@umc.edu

Work Phone:
(601) 984-2352

Biography

Dr. Kyle is a Professor of Pathology and the Director of the Clinical Chemistry, Special Chemistry, Serology and Toxicology laboratories at the University of Mississippi Medical Center. He is board certified as a Clinical Chemist (ABCC), Toxicological Chemist (ABCC), and Forensic Toxicology Specialist (ABFT). In addition to providing oversight to the laboratory, he also teaches medical students, dental students and Pathology residents. He is an international speaker, has authored over 50 peer-reviewed journal articles and book chapters, and serves as a reviewer for several scientific journals. His research interests include pharmaceutical toxicity, analytical method development, laboratory management and emerging biomarkers of disease.

Education

University of Mississippi, PhD, Pharmacology/Toxicology2006
Mississippi College, BS, Biology1991

Specialty Certification Licensure

Certification, Forensic Toxicology Specialist, American Board of Forensic Toxicology10/2011 - Present
Certification, Clinical Chemistry, American Board of Clinical Chemistry07/2012 - Present
Certification, Toxicological Chemistry, American Board of Clinical Chemistry07/2011 - Present
Certification, Clinical Chemist, National Registry of Certified Chemists02/2009 - Present
Certification, Toxicological Chemist, National Registry of Certified Chemists11/2006 - Present

Current Positions

Associate Professor, School of Medicine, Department of Pathology07/2014 - Present
Director of Clinical Chemistry, Special Chemistry, and Toxicology, Department of Pathology2012 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Pathology03/2009 - 06/2014
Interim Laboratory Director, Mississippi Public Health Laboratory06/2008 - 05/2009
Instructor, University of Mississippi Medical Center, School of Medicine, Department of Pathology03/2006 - 03/2009
Associate Director of Clinical Chemistry and Toxicology, University of Mississippi Medical Center, Department of Pathology03/2006 - 12/2011
School of Medicine, Department of Pathology

Sponsored Program Funding

Intramural, Interdisciplinary Quality Improvement Measures in Treating Cystic Fibrosis Patients, UMMC - Faculty Scholarship Exchange Award08/2013 - 07/2014
Extramural, Role of Eicosanoids in the Progression of Renal Disease in African Americans, NIH - COBRE07/2013 - 06/2016
Extramural, Methods Comparison for Systematic Toxicology Analysis by GC/MS, Thermo Scientific Inc.03/2013 - 02/2014
Extramural, Measureable Cardiotoxicity resulting from Therapeutic Micafungin Infusion, Astellas Pharma U.S., Inc.07/2011 - 06/2012
Extramural, Jackson Heart Study - Subcontract for Laboratory Services, NHLBI08/2010 - 12/2012
Extramural, Analgesic Technique on Pain and Biomarkers, National Institute of Health01/2010 - 12/2011
Extramural, Center for Research Excellence in Psychiatric Neuroscience, National Institutes of Health / National Center for Research Resources07/2007 - 06/2012

Publications

Statewide Newsletter

Kyle PB. Mississippi Toxicology Bulletin Mississippi Toxicology Bulletin. 2018. 3:1.2018
Kyle PB, Kaur J. Mississippi Toxicology Bulletin. Mississippi Toxicology Bulletin. 2017. 2:2.2017
Spencer L, Walley R, Kyle PB. Mississippi Toxicology Bulletin. Mississippi Toxicology Bulletin. 2017. 2:1.2017
Kyle PB. Mississippi Toxicology Newsletter. Mississippi Toxicology Newsletter. 2016. 1:12016

Journal Article

Morris R, Spencer SK, Barnes A, Bowles T, Kyle PB, Wallace K. Attenuation of oxidative stress and hypertension in an animal model of HELLP syndrome. European Journal of Pharmacology. 2018. 834:136-141.2018
Spencer S, Shaffery J, Kyle PB, Wallace K. Hypertension, anxiety and blood brain barrier permeability are increased in post-partum severe preeclampsia/HELLP syndrome rats. Hypertension. 20182018
Kasper AM,Ridpath AD, Gerona RR, Cox R, Galli R, Kyle PB, Parker C, Arnold JK, Chatham-Stephens K, Morrison MA, Olayinka O, Preacely N, Kieszak SM, Martin C, Schier JG, Wolkin A, Byers P, Dobbs T. Severe illness associated with reported use of synthetic cannabinoids: a public health investigation (Mississippi, 2015). Clinical Toxicology. 2018. 10:1-9.2018
Bean C, Spencer SK, Bowles T, Kyle PB, Williams JM, Gibbens J, Wallace K. Inhibition of T-cell activation attenuates hypertension, TNFα, IL-17, and blood-brain barrier permeability in pregnant rats with angiogenic imbalance. American Journal of Reproductive Immunology. 2016. 76(4):272-9.2016
Morris R, SPencer L, Kyle PB, Williams JM, Harris A, Owens MY, Wallace K. Hypertension in an Animal Model of HELLP Syndrome is Associated With Activation of Endothelin 1. Reproductive Sciences. 2016. 23(1):42-50.2016
Kasper AM, Ridpath AD, Arnold JK, Chatham-Stephens K, Morrison M, Olayinka O, Parker C, Galli R, Cox R, Preacely N, Anderson J, Kyle PB, Gerona R, Martin C, Schier J, Wolkin A, Dobbs T. Severe Illness Associated with Reported Use of Synthetic Cannabinoids - Mississippi, April 2015. Morbidity Mortality Weekly Report. 2015. 64(39):1121-2.2015
Jia Z, Johnson AC, Wang X, Guo Z, Driesbach AW, Lewin J, Kyle PB, Garrett MR. Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat. PLOS One. 2015. 10(7):e0132553.2015
Rajkowska G, Mahajan G, Sathyanesan M, Iyo AH, Moulana M, Kyle PB, Woolverton WL, Miguel-Hidalgo JJ, Stockmeier CA, and Newton SS. Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder. Journal of Psychiatric Research. 2015;65:53-62.2015
Wang X, Johnson A, Williams J, White T, Chade A, Zhang J, Liu R, Roman R, Lee J, Kyle P, Solberg W, and Garrett M. Nephron deficiency and predisposition to renal injury in a novel one-kidney genetic model. Journal of the American Society of Nephrology. 2014. In Press.2014
Driesbach AW, Smith SV, Kyle PB, Ramaiah M, Amenuke M, Garrett MR, Lirette ST, Griswold ME, and Roman RJ. Urinary CYP eicosanoid excretion correlates with glomerular filtration in African-Americans with chronic kidney disease. Prostaglandins and Other Lipid Mediators. 2014. In Press.2014
Westbrook L, Johnson AC, Regner KR, Williams JM, Mattson DL, Kyle PB, Henegar JR, and Garrett MR. Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. Journal of the American Society of Nephrology. 2014. In Press.2014
Wallace K, Morris R, Kyle PB, Cornelius D, Darby M, Scott J, Moseley J, Chatman K, and LaMarca B. Hypertension, Inflammation and T Lymphocytes are Increased in a Rat Model of HELLP Syndrome. Hypertension in Pregnancy.2014
Stover KR, Farley JM, Kyle PB, Cleary J. Cardiac Toxicity of Some Echinocandin Antifungals. Expert Opinion on Drug Safety. 2014. 13(1):5-14.2014
Slaughter TN, Paige A, Spires D, Kojima N, Kyle PB, Garrett MR, Roman RJ, Williams JM. Characterization of the Development of REnal Injury in Type-1 Diabetic Dahl Salt-sensitive Rats. Am J Physiol Regul Integr Comp Physiol. 2013; In Press2013
Cleary JD, Stover KR, Farley J, Daley W, Kyle PB, Hosler J. Cardiac toxicity of azole antifungals. Pharmacology and Pharmacy. 2013; 4:362-368.2013
Regner KR, Harmon AC, Williams JM, Stelloh C, Johnson AC, Kyle PB, Lerch-Gabbl A, White SM, Garrett MR. Increased Susceptibility ot Kidney Injury by transfer of Genomic Segment from SHR onto Dahl S genetic background. Physiol Genomics. 2012;44:629-637.2012
Kyle PB, Brown KB, Bailey AP, Stevenson JL. Reactivity of commercial Benzodiazepine Immunoassays to Phenazepam. J Anal Toxicol. 2012; 36:207-209.2012
Kyle PB, Lawrence TJ. Aberrant Lamellar Body Counts noted on teh Beckman Coulter Unicel DxH 800. Clin chem Lab Med. 2012;50:1631-1633.2012
Kyle PB, Smith SV, Baker RC, Kramer RE. Mass Spectrometric detection of CYP450 adducts following oxidative desulfuration of Methyl Parathion. J Appl Toxicol. 2013;33:644-651.2012
Kyle PB, Iverson RB, Gajagowni RG, Spencer L. Illicit Bath Salts: not for Bathing. J Miss State Med Assoc. 2011; 52:375-377.2011
Bogdan R, Fitzgibbon H, Woolverton WL, Bethea CL, Iyo AH, Stockmeier CA, Kyle PB, Austin MC. 5-HTTLPR Genotype and Gender, but not Chronic Fluoxetine Administration, are associated with Cortical TREK1 Protein Expression in Rhesus Macaques. Neurosci Lett. 2011; 503:83-86.2011
Cox RD, Kyle PB, Brackin B, Snazelle T, Surkin J. Blood Lead Levels in Mississippi Children. J Miss State Med Assoc. 2010; 51:206-210.2010
Szeczyk B, Albert PR, Rogaeva A, Fitzgibbon H, May WL, Rajkowska G, Miguel-Hidalgo JJ, Stockmeier CA, Woolverton WL, Kyle PB, Wang Z, Austin MC. Decreased expression of Freud-1/CC2D1A, aa transcriptional repressor of the 5-HT1A receptor in the prefrontal cortex of subjects with major depression. Int J Neuropsychopharmacol. 2010; 13:1089-1101.2010
Kyle PB. Beware of Carryover in Modern Chemistry Analyzers. Clinical Chemistry and Laboratory Medicine. 2010. 48(4):519-521.2010
Feyissa AM, Woolverton WL, Miguel-Hidalgo JJ, Wang Z, Kyle PB, Hasler G, Stockmeier CA, Iyo AH, Karolewicz B. Elevated level of Metabotropic Glutamate Receptor 2/3 in teh Prefrontal Cortex in Major Depression. Prog Neuropsychopharmacol Biol Psychiatry. 2010; 34:279-283.2010
Kyle PB, Daley WP. Domestic Abuse of the European Rave Drug Prolintane. J Anal toxicol. 2007; 31:415-418.2007
Adcock KG, Kyle PB, Deaton JS, Olivier JH, Hogan SM. Pharmacokinetics of Intranasal and Intratracheal Pentoxifylline in Rabbits. Pharmacotherapy. 2007; 27:200-206.2007
Glisson JK, Wood RL, Kyle PB, Cleary JD. Bioavailability of Promethazine in a topical Pluronic Lecithin Organogel: A Pilot Study. Int J Pharm Compd. 2005; 9:242-246.2005
Kyle PB, Adcock KG, Kramer RE, Baker RC. Use of Liquid Chromatography-Tandem Mass Spectrometry for the analysis of Pentoxifylline and Lisofylline in Plasma. Biomed Chromatogr. 2005; 19:231-236.2005
Zhu MY, Kyle PB, Hume AS, Ordway GA. The Persistent Membrane Retention of Desipramine causes lasting Inhibition of Norepinephrine. Neurochem Res. 2004; 29:419-427.2004
Kyle PB, Spencer JL, Purser CM, Hume AS. Drugs Detected in Suspected Pediatric Ingestions: a three-year review. J Miss State Med Assoc. 2004; 45:35-40.2004
Kyle PB, Spencer JL, Purser CM, Eddleman KC, Hume AS. Suspected Pediatric Ingestions: Effectiveness of Immunoassay Screens vs. Gas Chromatography/Mass Spectroscopy in the Detection of Drugs and Chemicals. J Toxicol Clin Toxicol. 2003; 41:919-925.2003
Kasper AM, Ridpath AD, Gerona RR, Cox R, Galli R, Kyle PB, Parker C, Arnold JK, Chatham-Stephens K, Morrison MA, Olayinka O, Preacely N, Kieszak SM, Martin C, Schier JG, Wolkin A, Byers P, Dobbs T, Severe illness associated with reported use of synthetic cannabinoids: a public health investigation (Mississippi, 2015). Clinical toxicology (Philadelphia, Pa.), 2019 Jan;57(1):10-182019
Morris R, Spencer SK, Barnes A, Bowles T, Kyle PB, Wallace K, Attenuation of oxidative stress and hypertension in an animal model of HELLP syndrome. European journal of pharmacology, 2018 Sep 5;834:136-1412018
Morris R, Spencer SK, Kyle PB, Williams JM, Harris A, Owens MY, Wallace K, Hypertension in an Animal Model of HELLP Syndrome is Associated With Activation of Endothelin 1. Reproductive sciences (Thousand Oaks, Calif.), 2016 Jan;23(1):42-502016
Bean C, Spencer SK, Bowles T, Kyle PB, Williams JM, Gibbens J, Wallace K, Inhibition of T-cell activation attenuates hypertension, TNFα, IL-17, and blood-brain barrier permeability in pregnant rats with angiogenic imbalance. American journal of reproductive immunology (New York, N.Y. : 1989), 2016 Oct;76(4):272-92016
Wang X, Johnson AC, Williams JM, White T, Chade AR, Zhang J, Liu R, Roman RJ, Lee JW, Kyle PB, Solberg-Woods L, Garrett MR, Nephron Deficiency and Predisposition to Renal Injury in a Novel One-Kidney Genetic Model. Journal of the American Society of Nephrology : JASN, 2015 Jul;26(7):1634-462015
Rajkowska G, Mahajan G, Maciag D, Sathyanesan M, Iyo AH, Moulana M, Kyle PB, Woolverton WL, Miguel-Hidalgo JJ, Stockmeier CA, Newton SS, Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder. Journal of psychiatric research, 2015 Jun;65:53-622015
Kasper AM, Ridpath AD, Arnold JK, Chatham-Stephens K, Morrison M, Olayinka O, Parker C, Galli R, Cox R, Preacely N, Anderson J, Kyle PB, Gerona R, Martin C, Schier J, Wolkin A, Dobbs T, Severe Illness Associated with Reported Use of Synthetic Cannabinoids - Mississippi, April 2015. MMWR. Morbidity and mortality weekly report, 2015 Oct 9;64(39):1121-22015
Stover KR, Farley JM, Kyle PB, Cleary JD, Cardiac toxicity of some echinocandin antifungals. Expert opinion on drug safety, 2014 Jan;13(1):5-142014
Wallace K, Morris R, Kyle PB, Cornelius D, Darby M, Scott J, Moseley J, Chatman K, Lamarca B, Hypertension, inflammation and T lymphocytes are increased in a rat model of HELLP syndrome. Hypertension in pregnancy, 2014 Feb;33(1):41-542014
Westbrook L, Johnson AC, Regner KR, Williams JM, Mattson DL, Kyle PB, Henegar JR, Garrett MR, Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. Journal of the American Society of Nephrology : JASN, 2014 Nov;25(11):2499-5102014
Dreisbach AW, Smith SV, Kyle PB, Ramaiah M, Amenuke M, Garrett MR, Lirette ST, Griswold ME, Roman RJ, Urinary CYP eicosanoid excretion correlates with glomerular filtration in African-Americans with chronic kidney disease. Prostaglandins & other lipid mediators, 2014 Oct;113-115:45-512014
Kyle PB, Smith SV, Baker RC, Kramer RE, Mass spectrometric detection of CYP450 adducts following oxidative desulfuration of methyl parathion. Journal of applied toxicology : JAT, 2013 Jul;33(7):644-512013
Slaughter TN, Paige A, Spires D, Kojima N, Kyle PB, Garrett MR, Roman RJ, Williams JM, Characterization of the development of renal injury in Type-1 diabetic Dahl salt-sensitive rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2013 Oct 1;305(7):R727-342013
Kyle PB, Brown KB, Bailey AP, Stevenson JL, Reactivity of commercial benzodiazepine immunoassays to phenazepam. Journal of analytical toxicology, 2012 Apr;36(3):207-92012
Regner KR, Harmon AC, Williams JM, Stelloh C, Johnson AC, Kyle PB, Lerch-Gaggl A, White SM, Garrett MR, Increased susceptibility to kidney injury by transfer of genomic segment from SHR onto Dahl S genetic background. Physiological genomics, 2012 Jun 15;44(12):629-372012
Kyle PB, Lawrence TJ, Aberrant lamellar body counts noted on the Beckman Coulter Unicel DxH 800. Clinical chemistry and laboratory medicine, 2012 Mar 9;50(9):1631-32012
Bogdan R, Fitzgibbon H, Woolverton WL, Bethea CL, Iyo AH, Stockmeier CA, Kyle PB, Austin MC, 5-HTTLPR genotype and gender, but not chronic fluoxetine administration, are associated with cortical TREK1 protein expression in rhesus macaques. Neuroscience letters, 2011 Oct 3;503(2):83-62011
Kyle PB, Iverson RB, Gajagowni RG, Spencer L, Illicit bath salts: not for bathing. Journal of the Mississippi State Medical Association, 2011 Dec;52(12):375-72011
Feyissa AM, Woolverton WL, Miguel-Hidalgo JJ, Wang Z, Kyle PB, Hasler G, Stockmeier CA, Iyo AH, Karolewicz B, Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression. Progress in neuro-psychopharmacology & biological psychiatry, 2010 Mar 17;34(2):279-832010
Kyle PB, Beware of carryover in modern chemistry analyzers. Clinical chemistry and laboratory medicine, 2010 Apr;48(4):519-212010
Szewczyk B, Albert PR, Rogaeva A, Fitzgibbon H, May WL, Rajkowska G, Miguel-Hidalgo JJ, Stockmeier CA, Woolverton WL, Kyle PB, Wang Z, Austin MC, Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression. The international journal of neuropsychopharmacology, 2010 Sep;13(8):1089-1012010
Cox RD, Kyle PB, Brackin B, Snazelle T, Surkin J, Blood lead levels in Mississippi children. Journal of the Mississippi State Medical Association, 2010 Aug;51(8):206-102010
Adcock KG, Kyle PB, Deaton JS, Olivier JH, Hogan SM, Pharmacokinetics of intranasal and intratracheal pentoxifylline in rabbits. Pharmacotherapy, 2007 Feb;27(2):200-62007
Kyle PB, Daley WP, Domestic abuse of the European rave drug prolintane. Journal of analytical toxicology, 2007 Sep;31(7):415-82007
Kyle PB, Adcock KG, Kramer RE, Baker RC, Use of liquid chromatography-tandem mass spectrometry for the analysis of pentoxifylline and lisofylline in plasma. Biomedical chromatography : BMC, 2005 Apr;19(3):231-62005
Zhu MY, Kyle PB, Hume AS, Ordway GA, The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function. Neurochemical research, 2004 Feb;29(2):419-272004
Kyle PB, Spencer JL, Purser CM, Hume AS, Drugs detected in suspected pediatric ingestions: a three-year review. Journal of the Mississippi State Medical Association, 2004 Feb;45(2):35-402004
Kyle PB, Spencer JL, Purser CM, Eddleman KC, Hume AS, Suspected pediatric ingestions: effectiveness of immunoassay screens vs. gas chromatography/mass spectroscopy in the detection of drugs and chemicals. Journal of toxicology. Clinical toxicology, 2003;41(7):919-25
Adeosun SO, Hou X, Jiao Y, Zheng B, Henry S, Hill R, He Z, Pani A, Kyle P, Ou X, Mosley T, Farley JM, Stockmeier C, Paul I, Bigler S, Brinton RD, Smeyne R, Wang JM, Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease. PloS one, 2012;7(11):e50040
Glisson JK, Wood RL, Kyle PB, Cleary JD, Bioavailability of promethazine in a topical pluronic lecithin organogel: a pilot study. International journal of pharmaceutical compounding, 2005 May-Jun;9(3):242-6
Jia Z, Johnson AC, Wang X, Guo Z, Dreisbach AW, Lewin JR, Kyle PB, Garrett MR, Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat. PloS one, 2015;10(7):e0132553

Abstracts

Kyle PB, Kaur J. Evaluation of new specimen validity markers. Journal of Analytical Toxicology. Annual Meeting Abstracts. 20182018
Gibbens JD, SPencer SK, Bowles T, Kyle PB, Morris R, Wallace K. Anti-angiogenic imbalance during pregnancy: is the Fas/FasL system a contributor? American Journal of Obstetrics and Gynecology. 2017. 216(1):S546.2017
Bean C, Spencer SK, Bowles T, Kyle PB, Evidence that perinatal hypertension and inflammation leads to chronic inflammation, hypertension and neurological changes in an animal model of HELLP syndrome. 37th Annual Meeting of the Society for Maternal Fetal Medicine: The Pregnancy Meeting. January 23-28, 2017.2017
Kasper AM, Gerona R, Ridpath A, Galli R, Arnold J, Cox R, Anderson J, Kyle P, Martin C, Shier J, Wolkin A, Dobbs T. Severe illness associated with a novel synthetic cannabinoid - Mississippi, April 2015. 65th Annual Epidemic Intelligence Service Conference. May 2-5, 2016. page 98.2016
Kyle PB, Chekuri S. Laboratory utilization of HbA1c, PSA and BMP in an academic medical center. Clinical Chemistry. 2015. 61(10):s170.
2015 Annual Meeting Abstracts. American Assocaition for Clinical Chemistry.
2015
Kyle PB and Brown KB. Using Technological Advances to Improve Laboratory Turn around Times. Clinical Chemistry. 2014 Annual Meeting Abstracts. S201, #B171.2014
Kyle PB, Bhaijee F, Magee L, Booth D. A highly sensitive quadrupole GC-MS for quantitative and qualitative toxicology. Mass Spectrometry: Applications to the Clinical Lab. 2014.2014
Kyle PB, Bhaijee F, Magee L, and Booth D. A highly sensitive quadrupole GC-MS for quantitative and qualitative toxicology. Journal of Analytical Toxicology. 2013;37(8):xx.2014
Kyle PB, Bhaijee F, Magee L, Booth D. A Quadrupole GC/MS with Dual-Role Toxicology Capability. Journal of Analytical Toxicology2013
Johnson AC, Guo Z, Kyle PB, and Garrett MR. Use of Congenic Strains, Comparative Genome Hybridization, and Whole Genomic Sequencing to Dissect the Genetic Basis of Chronic Kidney Disease in teh Dahl S. Hypertension. 2013;62:A517.2013
Wallace K, Darby M, Kyle PB, Morris R, Moseley J, Frazier K, Scott J, and LaMarca B. Hypertension in a rat model of HELLP syndrome is associated with increased TNF-alfa, IL-6, and CD4 T cell activation. FASEB Journal, 2013;27:1115.72013
Slaughter T, Paige A, Fan F, Kyle P, Geurts AM, Jacob HJ, Roman RJ, and Williams JM> Involvement of Matrix Metalloproteinase-2 During the Progression of Renal Disease in Diabetic Dahl Salt-Sensitive Rats. Hypertension. 2012; 60(3):A55.2012
Dreisbach AW, Smith SV, Kyle PB, Ramaiah M, Amenuke M, Garrett MR, Lirette ST Griswold ME, and Roman RJ. Urinary CYP Eicosanoid Excretion Correlates with Glomerular Filtration Rate in African-Americans with Chronic Kidney Disease. Hypertension. 2012; 60(3):A348.2012
Slaughter T, Paige A, Rucker C, Kyle P, Kojima N, Garrett MR, Roman RJ, and Williams JM. Temporal Characterization of the Development of Diabetic-Induced Renal Disease in Strains of Goto-kakizaki Rats. Hypertension. 2012; 60(3):A134.2012
Wallace K, Darby M, Kyle P, Scott J, Moseley J, Brewer J, Owens MY, and LaMarca B. Hypertension in a Rat Model of HELLP Syndrome is Associated with T Helper 1 Type Immune Activation. Hypertension. 2012; 60:A1762012
Westbrook L, Regner KR, Johnson A, Lee J, Kyle PB, Mattson DL, and Garrett MR. Loss of Nr4a1 on a Hypertensive Genetic Background Promotes Immune-Mediacted Renal Injury. Hypertension. 2012; 60(3 Abstracts):A1.2012
Kyle PB, Bhaijee F, and Booth DD. Clinical Toxicology Results after Supplementation of Commercial GC/MS Libraries. Clinical Chemistry. 2012; 58(9):A193.2012
Williams JM, Slaughter T, Wells A, Rucker C, spires D, Kyle PB, and Roman RJ. Increased MMP-9 Activity During the Progression of Renal Injury in Type-2 Diabetic Nephropathy Rats. FASEB Journal. 2012; 26(supplement):687.42012
Slaughter T, Spires D, Rucker C, WElls A, Kyle P, Roman RJ, and Williams JM. The Reduction of Renal Injury in Diabetic Dahl Salt-Sensitive Rats with Insulin is Associated with Decreased MMP Activity. FASEB Journal. 2012; 26:687.32012
Rucker C, Spires D, Slaughter T, Wells A, Kyle PB, Roman R, and Williams J. Involvement of Matrix Metalloproteinases During the Progression of Renal Injury in Type-II diabetic Nephropathy Rats. Journal of the Mississippi Academy of Sciences. 2012; 57(1):1092012
Spires D, Slaughter T, Rucker C, Wells A, Kyle PB, roman RJ, and Williams JM. Controlling Plasma Glucose LEvels Reduces Renal Injury in Diabetic Dahl Salt-Sensitive Rats. Journal of the Mississippi Academy of Sciences. 2012; 57(1):1092012
Stover KR, Kyle PB, Farley J, and Cleary JD. Echinocandin Myocardial Toxicity.2011
Kyle PB, Booth D, Magee L, and Spencer JL. Comparison of Six Extraction methods for Emergency Toxicology Screening. Clinical Chemistry. 2011;57(S10):A552011
Wang J, Adeosun S, Jiao Y, Henry S, Hill R, Zheng B, Sun c, Hou X, Pani A, Kyle P, Bigler S, Farley S, Stockmeier C, Paul I, Brinton RD, Smeyne R. The Impact of a Neurogenic Agen, Allopregnanolone in Rodent Models of Alzheimer's and Parkinson's Disease. Alzheimer's & Dementia. 2011;7(4):s667.2011
Austin MC, Goswami DB, Fitzgibbon H, Woolverton WL, Stockmeier CA, Kyle PB, Bethea CL, and Barth J. Microarray Gene Expression Profiling of Prefrontal Cortex in Chronic Fluoxetine-Treated Rhesus Monkeys: Sex Differences. Biological Psychiatry. 2011; 69:56s.2011
Spires D, Wells A, Zhang J, Kyle PB, Roman RJ, and Williams JM. Progression of Diabetic-Induced Renal Injury in Diabetic Dahl Salt-Sensitive Rats Journal of the Mississippi Academy of Sciences. 2011; 69:56s.2011
Brown J, Wells A, Kyle PB, Roman RJ, and Williams JM. Effects of a High Salt Diet on the Progression of Renal Injury in Diabetic Dahl Salt-Sensitive Rats. Journal of the Mississippi Academy of Science. 2011. 56(1):141.2011
Legutko B, Abel K, Migual-Hidalgo J, Wang Z, Kyle P, Woolverton W, Maciag D, Stockmeier C, and Rajkowska G. Fluoxetine Treatment Does Not Alter Density or Size of CNPase-Immunoreactive Oligodendrocytes in Prefrontal White Matter in Rhesus Monkeys Biol Psychiatry. 2010. 67(9):54s. Accepted for Publication2010
Feyissa AM, Chandran A, Legutko B, Woolverton WL, Wang Z, Austin M, Miguel-Hidalgo JJ, Rajkowska G, Kyle P, Stockmeier CA, and Karolewicz B. Reduced Level of Metabotropic Glutamate Receptor 5 (mGlu5R) Protein in the Prefrontal Cortex in Major Depressive Disorder. Soc Neuroscience. 2009. 34:156.4.2009
Adcock KG, Kyle PB, Deaton JS, and Olivier J. Pentoxifylline Pharmacokinetics Following Two Novel Delivery Techniques American College of Clinical Pharmacy. 2004. 24(10):1453 abstract 219.2004

Book Chapter

Kyle PB. Toxicology: GC-MS. Mass Spectrometry for the Clinical Laboratory. Elsevier, Academy Press. San Diego, CA. Eds. Nair H. and Clarke W. 2017. ISBN: 978-0-12-800871-3.2017

Book

Kyle PB, Fuller DC, Garg U, Hammett-Stabler CA, Hoess E, Johnson-Davis K, Kapur BM, Langman LJ, LeGatt DF, Loughmiller D, Pesce A, Sadek W, Smith MP, Watson ID, Wolf CE, Wu A, Zhang YV. Toxicology and Drug Testing in the Medical Laboratory. CLSI. Toxicology and Drug Testing in the Medical Laboratory. 3rd ed. CLSI Guideline C52 (ISBN 1-56238-808-8 [Print]; ISBN 1-56238-809-6 [Electronic). Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087 USA, 2017.2017

Presentations

National and International Invited Seminars/Lectures, Accurate Results in Clinical Laboratories: Addressing Pre-Analytical, Analytical, and Post Analytical Errors, American Society for Clinical Pathology, Chicago, IL09/2024
State/Local Invited Seminars/Lectures, Toxicology: Mississippi has a Problem You can help Solve through Testing, Pathology for Primary Care Specialists, Ridgeland, MS03/2024
National and International Invited Seminars/Lectures, Illicit Opioids: What you Should Know, National Opioid Awareness Day, Abbott Diagnostics, Webinar - Worldwide09/2023
National and International Invited Seminars/Lectures, Navigating Laboratory Issues in the Preanalytical, Analytical and Postanalytical Phases, American Association for Clinical Chemistry, Anaheim, CA07/2023
National and International Invited Seminars/Lectures, Biotin Interference in Laboratory Assays, International Federation for Clinical Chemistry, Rome, Italy05/2023
State/Local Invited Seminars/Lectures, Toxicology: Options in Testing and Interpretation of Results, Pathology for Primary Care Specialists, Flowood, MS05/2023
National and International Invited Seminars/Lectures, Strategies for Improving Laboratory Turnaround Times, American Association for Clinical Chemistry, Chicago, IL07/2022
State/Local Invited Seminars/Lectures, Pharmacokinetics of THC and effects on Driving, Juvenile Drug Court, Web Conference - Hattiesburg, MS07/2022
National and International Invited Seminars/Lectures, Beautiful skin but erroneous test results: The AACC Academy Guidance Document on
Biotin Interference in Laboratory Immunoassays, American Association for Clinical Chemistry, Anaheim, California
08/2019
National and International Invited Seminars/Lectures, Biotin Interference in Laboratory Immunoassays, Canadian Society of Clinical Chemists, Saint John, Canada06/2019
National and International Invited Seminars/Lectures, Evaluating New Specimen Validity Markers., Society of Forensic Toxicology, Annual Meeting, Minneapolis, MN10/2018
State/Local Invited Seminars/Lectures, Toxicology: Drug Trends and Ways People Avoid Detection., UMMC Advance Practice Providers, Annual Regional Meeting, Jackson, MS10/2018
Regional Invited Seminars/Lectures, Addressing the Opioid Epidemic: Understanding the Problem and How to Fix It., American Society of Clinical Laboratory Sciences, Annual Bi State (MS & LA) Meeting, Biloxi, MS04/2018
State/Local Invited Seminars/Lectures, Toxicology Testing in Pain Management., Physician Prescriber Series, University of MS Medical Center, Jackson, MS03/2018
National and International Invited Seminars/Lectures, Applications of High Resolution Mass Spectrometry in Forensic Toxicology., Society of Forensic Toxicology, Annual Meeting, Dallas, TX10/2016
National and International Invited Seminars/Lectures, The recently Revised CLSI C52 - Toxicology and Drug Testing in the Clinical Laboratory., American Association for Clinical Chemistry, Annual Meeting, Philadelphia, PA08/2016
National and International Invited Seminars/Lectures, Tactics for Reducing Laboratory Turn-Around Times., American Association for Clinical Chemistry, Annual Meeting, Philadelphia, PA08/2016
National and International Invited Seminars/Lectures, Laboratory Utilization of HbA1c, PSA and BMP in an Academic Medical Center., Americal Association for Clinical Chemstry, Annual Meeting, Atlanta, GA07/2015
Regional Invited Seminars/Lectures, Immunoassay Interactions and Interferences., Americal Association for Clinical Chemistry - Southeast Section, Orange Beach, AL05/2015
Psychiatry Grand Rounds, Toxicology Testing: Differentiating False-Positive and False-Negative Results., UMMC Department of Psychiatry, University of Mississippi Medical Center06/2014
Regional Invited Seminars/Lectures, Toxicology in the Modern World: From synthetic opiods to bath salts., American Society for Clinical Laboratory Science, Annual Bi-State Meeting, Biloxi, MS05/2014
Regional Invited Seminars/Lectures, Tactics for Reducing Laboratory Turn Around Times., Annual Tri-State American Society for Clinical Laboratory Science Region 3 meeting, Biloxi, MS11/2013
National and International Invited Seminars/Lectures, Issues in Providing Regional Toxicology Services., American Association for Clinical Chemistry - Annual Meeting, Houston, TX, USA07/2013
Regional Invited Seminars/Lectures, Current Methods for Fetal Lung Maturity Testing., Annual Tri-State American Society for Clinical Laboratory Science Region 3 meeting, Tunica, MS04/2012
Scientific Presentations, Assay Harmonization - Why do we need it, Where are we going?, University of North Carolina, Chapel Hill, North Carolina05/2011

Honors, Awards, and Recognition

Clinical Pathology Attending of the Year, University of Mississippi Medical Center, Pathology2024
Excellence in Research Award, University of MS Medical Center2020
Clinical Pathology Attending of the Year, University of Mississippi Medical Center, Pathology2019
Leadership and Service Recognition Award, Clinical and Laboratory Standards Institute2018
2015 Outstanding Speaker Award, American Association for Clinical Chemistry2015
2013 Outstanding Speaker Award, American Association for Clinical Chemistry2014
Clinical Chemist Recognition Award, American Association for Clinical Chemistry2011
Young Investigator Scholarship, GenNext Technologies Inc.2006

Professional Membership and Service

Association for Diagnostics and Laboratory Medicine, Member2024 - Present
Association for Diagnostics and Laboratory Medicine, Fellow2024 - Present
American Board of Clinical Chemistry, Board of Directors of a Company2014 - 2019
American Association for Clinical Chemistry, Fellow2013 - 2023
Clinical and Laboratory Standards Institute, Member2013 - Present
Society of Forensic Toxicologists, Member2007 - Present
American Association for Clinical Chemistry, Member2006 - 2023
American Association for Mass Spectrometry, Member2006 - Present

Committee Service

Annual Meeting Organizing Committee, Association for Diagnostics and Laboratory Medicine, Member2023 - 2024
Document Development Committee, Association for Diagnostics and Laboratory Medicine, Co-Chair2022 - Present
UMMC COVID-19 Biosurveillance Task Force, Member2021 - 2023
Annual Meeting Organizing Committee, American Association for Clinical Chemistry, Member2019 - 2020
Toxicology Exam Committee, American Board of Clinical Chemistry, Chair2019 - 2019
Document Development Committee on Biotin Interference, AACC Academy Council, American Assocation for Clinical Chemistry, Chair2018 - 2020
AACC Academy Council, American Association for Clinical Chemistry, Director2018 - 2021
Clinical Chemistry Expert Panel, Clinical and Laboratory Standards Institute, Member2018 - 2019
UMMC Opioid Task Force, Member2018 - Present
Lab Test Utilization Committee, Member2017 - Present
Chemistry/Toxicology Expert Advisory Panel, The Joint Commission, Member2016 - 2016
Abstract Review Committee, National Academy for Clinical Biochemistry, Member2015 - 2015
Annual Meeting Program Committee, American Association for Clinical Chemistry, Southeast Section, Member2015 - 2015
Toxicology Exam Subcommittee, American Board of Clinical Chemistry, Member2014 - 2019
Exam Credentialing Committee, American Board of Clinical Chemistry, Member2014 - 2019
Board of Directors, American Board of Clinical Chemistry, Member2014 - 2019
C52 Document Revision Committee, Clinical and Laboratory Standards Institute, Chair2014 - 2016
American Association for Clinical Chemistry - Southeast Section, Chair2014 - 2014
Annual Meeting Abstract Review Committee, American Association for Clinical Chemistry, Member2014 - 2016
Annual Meeting Program Committee, American Association for Clinical Chemistry - Southeast Section, Chair2014 - 2014
Laboratory Steering Committee for Ebola Preparation, Member2014 - 2015
Interdisciplinary Quality Improvement Committee for treatment of cystic fibrosis patients with aminoglycoside antibiotics, Member2014 - 2015
Clinical Chemistry Committee, Clinical and Laboratory Standards Institute, Member2013 - 2016
American Association for Clinical Chemistry TDM/Toxicology Division, Board of Directors2013 - 2015
Medical Student Research Program Commitee, Member2012 - 2015
Jackson Heart Study - Laboratory Subcommittee, Member2011 - Present
MEDICAL CENTER-FACULTY SENATE, Chair2010 - 2011
MEDICAL CENTER-SACS LEADERSHIP, Member2010 - 2011
Medical Center - Quality Enhancement Plan Development Committee, Member2010 - 2014
MEDICAL CENTER-FACULTY DEVELOPMENT, Member2010 - 2011
UMMC Laboratory Safety Committee, Chair2010 - Present
Graduate Alumni Association - Board of Directors, Member2009 - 2013
THE UNIVERSITY HOSPITALS AND CLINICS-PHARMACY AND THERAPEUTICS, Member2008 - Present
MEDICAL CENTER-RADIATION/LASER SAFETY, Member2008 - Present
MEDICAL CENTER-FACULTY SENATE, Member2008 - 2014
Center for Psychiatric Neuroscience, Animal Core Supervisor2007 - 2010

Community Service

BSA Troop 178, Boy Scouts of America, Scoutmaster03/2014 - 05/2022

Other Service

Practical Laboratory Medicine2017 - 12/2017
Drug and Alcohol Dependence2016 - 12/2016
American Journal of Forensic Science2016 - 12/2016
Annual School of Medicine Research Day, Judge2013 - 12/2015
Journal of Applied Toxicology2013 - 12/2013
Journal of Obstetrics and Gynaecology Research2013 - 2013
Clinica Chimica Acta2012 - Present
Clinical Chemistry and Laboratory Medicine2012 - Present
Journal of Clinical Toxicology2012 - 12/2012
Laboratory Inspection, College of American Pathologists, Laboratory Inspector07/2011 - 07/2011
Clinical Biochemistry2011 - 12/2011
Journal of Analytical Toxicology2011 - 12/2019
Laboratory Inspection, College of American Pathologists, Laboratory Inspector05/2009 - 05/2009
Annual SHRP Research Day, Judge2009 - 12/2012
Pediatrics International2009 - 12/2009
Laboratory Inspection, College of American Pathologists08/2007 - 08/2007
American Journal of Clinical Pathology2007 - 12/2007
Laboratory Inspection, College of American Pathologists, Laboratory Inspection10/2006 - 10/2006
Rapid Communications in Mass Spectrometry2006 - 12/2006
Chemical Terrorism Registry, Society of Toxicology, Member2004 - 12/2008

Teaching Experience

637, Dentistry, Course, Lecturer, Dental PathologySummer 2018
621, Medicine, Course, Lecturer, Medical PathologySpring 2018
637, Dentistry, Course, Lecturer, Dental PathologySummer 2017
621, Medicine, Course, Lecturer, Medical PathologySpring 2017
637, Dentistry, Course, Lecturer, Dental PathologyFall 2016
621, Medicine, Course, Lecturer, Medical PathologySpring 2016
621, Medicine, Course, Lecturer, Medical PathologySpring 2015
637, Dentistry, Course, Lecturer, Dental PathologyFall 2015
621, Medicine, Course, Lecturer, Medical PathologySpring 2014
621, Medicine, Course, Lecturer, Medical PathologySpring 2013
621, Medicine, Course, Lecturer, Medical PathologySpring 2012
621, Medicine, Course, Lecturer, Medical PathologySpring 2011
621, Medicine, Course, Lecturer, Medical PathologySpring 2010
621, Medicine, Course, Lecturer, Medical PathologySpring 2009
621, Medicine, Course, Lecturer, Medical PathologySpring 2008
703, Graduate, Course, Lecturer, Orientation to Pharmacological ResearchFall 2008 - 2010
621, Medicine, Course, Lecturer, Medical PathologySpring 2007 - 2011

Directed Student Learning

Preceptor2008 - 2008

Residency Training

Anatomic/Clinical Pathology Residency, Training Faculty2006 - Present