Brian M. Kirmse, MD
Professor
Department:
SOM-Peds-Genetics
Email:
bkirmse@umc.edu
Work Phone:
(601) 984-1900
Biography
Born in Miami, FL. Attended University of Miami as undergraduate (Biology/Chemistry) and University of Miami School of Medicine for Medical School. Louisiana State University Health Sciences Center for Pediatrics Internship; Pediatrics Residency at University of Florida/Shands Hospital. Clinical Genetics and Clinical Biochemical Genetics Fellowships at Ichan School of Medicine at Mount Sinai in New York.
Joined University of Mississippi Medical Center first as Telehealth Provider in 2014 based at Children's National Medical Center in Washington, DC and then moved to Jackson in 2015 to direct the Program for Inherited Disorders of Metabolism. Appointed Division Chief of Pediatric Medical Genetics in 2017.
Education
| George Washington University, MS, Clinical Translational Science | 2015 |
| Mount Sinai School of Medicine, MD, Clinical Biochemical Genetics | 2010 |
| Mount Sinai School of Medicine, MD, Medical Genetics & Genomics | 2007 |
| University of Fla./Shands, MD, Pediatrics | 2004 |
| Louisiana State Health Sciences Center, MD, Pediatrics | 2002 |
| University of Miami SOM, MD, Medicine | 2001 |
| University of Miami, BS, Biology, Chemistry | 1997 |
Specialty Certification Licensure
| Certification, Clinical Biochemical Genetics, American Board of Medical Genetics | 01/2011 - Present |
| Certification, American Board of Medical Genetics | 09/2009 - 12/2019 |
| Re-certification, Board Certification, American Board of Pediatrics | 07/2015 - Present |
| Licensure, Ms. State Medical | 06/2020 |
Current Positions
| Fellowship Director, School of Medicine, Department of Pediatrics | 11/2018 - Present |
| Division Chief, School of Medicine, Department of Pediatrics | 12/2017 - Present |
| Associate Professor, School of Medicine, Department of Pediatrics | 08/2015 - Present |
| Director, School of Medicine | 08/2015 - Present |
| Director for Inherited Disorders of Energy Metabolism Program, School of Medicine | 07/2017 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Director Newborn Screening Program, Children's National Medical Center, School of Medicine | 07/2010 - 07/2015 |
| Assistant Professor, George Washington University, Division of Medical Genetics & Metabolism, School of Medicine | 07/2010 - 07/2015 |
| Course Director, Mount Sinai, Medical Genetics, School of Medicine | 07/2007 - 06/2010 |
| Assistant Professor, Mt. Sinai Division of Medical Genetics, Dept. of Genetics & Genomic Sciences, School of Medicine | 07/2007 - 06/2010 |
| Attending, Mt. Sinai Program for Inherited Metabolic Diseases, School of Medicine | 07/2007 - 06/2010 |
| Associate Director, Mt. Sinai Center for Fabry Disease, School of Medicine | 07/2007 - 06/2010 |
| Instructor, New York Medical College, School of Medicine | 07/2004 - 06/2005 |
| Assistant Residency Program Director, Mt. Sinai Dept. Genetics & Genomics, School of Medicine |
Sponsored Program Funding
| Extramural, PopSeq: Return of Genomic Results and Estimating Penetrance in Population-Based Cohorts, Jackson Heart Study | 03/2021 - 06/2022 |
| Extramural, SouthSeq: DNA Sequencing for Newborn across the Deep South (CSER2) | 08/2017 - 05/2022 |
| Extramural, Genetics of metabolism in antiretroviral treated children (KL2), NIH/Clinical Translational Science Institute | 07/2011 - 06/2014 |
| Extramural, NIH Loan Repayment Program in Pediatric Research: Metabolic effects of HIV drugs in Children, NIH | 07/2011 - 06/2018 |
| Extramural, Genetics of metabolism in antiretroviral treated children, DC Center for AIDS Research | 05/2011 - 04/2012 |
| Extramural, National Research Service Award (NRSA) "Research Training for Medical Geneticists", NIH | 07/2009 - 06/2010 |
| Extramural, Exploratory evaluation of mitochondrial dysfunction in children exposed to NRTI-based therapy to reduce perinatal transmission of HIV, Thrasher Research Fund | 02/2009 - 01/2011 |
| Extramural, Mitochondrial dysfunction and NRTI therapy in children, New York State | 12/2008 - 07/2010 |
Publications
Journal Article | |
| Boothe E, West B, Hendon LG, Kaplan JD, Kirmse B. Asynchronous telemedicine for clinical genetics consultations in the NICU: a single center's solution. J Perinatol. 2021 Jul 23. doi: 10.1038/s41372-021-01070-1. | 2021 |
| Goodman LD, Cope H, Nil Z, Ravenscroft TA, Charng WL, Lu S, Tien AC, Pfundt R, Koolen DA, Haaxma CA, Veenstra-Knol HE, Wassink-Ruiter JSK, Wevers MR, Jones M, Walsh LE, Klee VH, Theunis M, Legius E, Steel D, Barwick KES, Kurian MA, Mohammad SS, Dale RC, Terhal PA, van Binsbergen E, Kirmse B, Robinette B, Cogné B, Isidor B, Grebe TA, Kulch P, Hainline BE, Sapp K, Morava E, Klee EW, Macke EL, Trapane P, Spencer C, Si Y, Begtrup A, Moulton MJ, Dutta D, Kanca O; Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Bellen HJ, Tan QK. TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila. Am J Hum Genet. 2021 Jul 19:S0002-9297(21)00267-6. doi: 10.1016/j.ajhg.2021.06.019. | 2021 |
| Kour S, Rajan DS, Fortuna TR … Kirmse B … et al. Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder. Nature Communications | 2021 |
| Whalen S, Shaw M, Mignot C… Kirmse B … et al. Further delineation of BCAP31-linked intellectual disability: description of 17 new families with LoF and missense variants. European Journal Human Genetics (Nature Publishing Co.) | 2021 |
| Hobbs CV, Martin LM, Kim SS, Kirmse B, et al Factors Associated with Positive SARS-CoV-2 Test Results in Outpatient Health Facilities and Emergency Departments Among Children and Adolescents Aged <18 Years - Mississippi, September-November 2020 MMWR Morb Mortal Wkly Rep 2020;69:1925-9. | 2020 |
| Bradbury RS, Arguello I, Lane M, Cooley G, Handali S, Dimitrova SD, Kirmse B, et. al Parasitic Infection Surveillance in Mississippi Delta Children American Journal Tropical Medical Hygene | 2020 |
| Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents New England Journal of Medicine | 2020 |
Presentations
| State/Local Invited Seminars/Lectures, Genetics of SARS-CoV2 infection and its complications in children, MS Pediatric Pandemic Education Network, Remote (Statewide Access) | 09/2020 |
| National and International Invited Seminars/Lectures, Expanding Access to Clinical Genetics Services: Lessons from Mississippi, Nuffield Department of Clinical Neurosciences, Oxford, UK | 07/2019 |
| State/Local Invited Seminars/Lectures, Inherited disorders of energy metabolism in Mississippi, Pediatrics Grand Rounds, Jackson, MS | 10/2018 |
| Poster Presentation, Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism., American College of Medical Genetics Clinical Genetics Meeting, Phoenix, AZ | 03/2017 |
| Poster Presentation, Placental metabolomics in HIV-infected and uninfected women reveal differences in multiple pathways of intermediary energy metabolism., American College of Medical Genetics Clinical Genetics Meeting, Phoenix, AZ | 03/2017 |
| State/Local Invited Seminars/Lectures, Newborn Screening Follow up in Mississippi, MS Department of Health, Jackson, MS | 09/2016 |
Honors, Awards, and Recognition
| Innovation Award, Department of Pediatrics, UMMC | 2018 |
| Resident as Teacher Award, Dept. of Pediatrics, University of Florida | 2004 |
| Excellence in Teaching Award, Aesculaptian Society, LSU School of Medicine | 2002 |
| Henry Stanford Scholarship, University of Miami, College of Arts & Sciences | 1993 |
Professional Membership and Service
| Mitochondrial Medicine Society, Member | 2017 - Present |
| Society for Inherited Metabolic Diseases, Member, Member Education Committee | 2010 - Present |
| Society for the Study of Inborn Errors of Metabolism, Member | 2010 - Present |
| Mitochondrial Research Society, Member | 2008 - Present |
| American Society of Human Genetics, Member | 2007 - Present |
| American Academy of Pediatrics, Member | 2001 - Present |
Committee Service
| Genetic Testing Stewardship Committee, Member | 2021 - Present |
| MSDH Genetics Advisory Committee, Vice Chair | 2016 - Present |
| MSDH Genetics Advisory Board, Member | 2015 - Present |
| Pediatric Discovery Counsel, Member | 2015 - Present |
Community Service
| District of Columbia Developmental Center for AIDS Research, Member | 11/2010 - 06/2015 |
Other Service
| Pediatric HIV/AIDS Cohort Study (PHACS), Maternal Exposures Working Group | 10/2010 - Present |
Teaching Experience
| Medicine, Small Group, Guest Presenter, Clinical Bioethics | Annual M4 |
| Medicine, Lecture, Lecturer, Genetics: Mitochondrial Disorders | Spring M2 - 2018 |
| Medicine, Lecture, Lecturer, Genetics: Clinical Applicability of Genetics II | Spring M2 - 2018 |
| Medicine, Lecture, Lecturer, Genetics: Mitochondrial Disorders | Spring M2 - 2019 |
| Medicine, Lecture, Lecturer, Biochemistry | Fall M1 |
Directed Student Learning
| Doctoral Advisory Committee Member, To be determined Advised: Bethany Robinette | 2019 - Present |
| Doctoral Advisory Committee Member, Comorbid depression in patients with PKU Advised: Michelle Tharp | 2017 - 2019 |
| Clinic Attending Physician | 2015 - Present |
| Clinic Attending Physician | 2015 - 2019 |
Fellows supervised
| Clinical Genetics, Research Advisor, 1 fellows supervised | 12/2017 - Present |
| Clinical Genetics, Research Advisor, 1 fellows supervised | 08/2015 - Present |
Residency Training
| Medical Genetics, Program Director | 2017 - 05/2021 |
| Maternal Fetal Medicine, Attending Physician | 2015 - Present |
| Child Neurology, Attending Physician | 2015 - Present |
| Pediatrics, Attending Physician | 2015 - Present |