Eric M. George

Eric M. George

Associate Professor

Department:
SOM-Physiology & Biophysics

Email:
egeorge@umc.edu

Work Phone:
(601) 984-5299

Education

University of Mississippi Medical Center, PhD, Biochemistry2010
University of Mississippi Medical Center, MS, Biological Sciences2009
University of Mississippi, BA, Biochemistry/History2002

Current Positions

Assistant Professor, School of Medicine, Department of Biochemistry08/2013 - Present
Assistant Professor, School of Medicine, Department of Physiology And Biophysics03/2013 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Instructor, University of Mississippi Medical Center, School of Medicine, Department of Physiology And Biophysics07/2011 - 07/2011

Sponsored Program Funding

Extramural, A novel Therapy for Preeclampsia, NIH/NLBI07/2017 - 06/2022
Extramural, A novel proangiogenic therapy for preeclampsia, AHA07/2016 - 06/2018
Extramural, A novel proangiogenic therapy for preeclampsia, NIGMS03/2014 - 03/2016
Extramural, Hypertensive Mechanisms in Preeclampsia, NHLBI03/2014 - 02/2017
Extramural, A Novel Protein Delivery System for Therapy of Preeclampsia, NHLBI01/2014 - 12/2018
Intramural, Development of an anti-angiogenic sFlt-1 miniprotein for treatment of corneal neovascularization, IRSP05/2013 - 04/2014
Extramural, The Kidney and Pregnancy, American Heart Association07/2011 - 06/2013

Publications

Letter

George EM, Granger JP, Response to: Using Carbon Monoxide Releasing Molecules in Models of Pre-Eclampsia: When Should We Be Monitoring Vascular Effects? American journal of hypertension, 2017 Oct 1;30(10):e112017

News

George EM, Granger JP, Hypertension: A new genetic clue to unravel the origins of pre-eclampsia. Nature reviews. Nephrology, 2017 Oct;13(10):599-6002017

Journal Article

George EM The disease of theories: unravelling the mechanisms of preeclampsia The Biochemist. 39:1: 22-25.2017
Eddy AC, Chapman H, George EM, Acute Hypoxia and Chronic Ischemia Induce Differential Total Changes in Placental Epigenetic Modifications. Reproductive sciences (Thousand Oaks, Calif.), 2019 Jun;26(6):766-7732019
Eddy AC, Bidwell GL 3rd, George EM, Pro-angiogenic therapeutics for preeclampsia. Biology of sex differences, 2018 Aug 25;9(1):362018
George EM, Cockrell K, Arany M, Stec DE, Rimoldi JM, Gadepalli RSV, Granger JP, Carbon Monoxide Releasing Molecules Blunt Placental Ischemia-Induced Hypertension. American journal of hypertension, 2017 Sep 1;30(9):931-9372017
Logue OC, Mahdi F, Chapman H, George EM, Bidwell GL 3rd, A Maternally Sequestered, Biopolymer-Stabilized Vascular Endothelial Growth Factor (VEGF) Chimera for Treatment of Preeclampsia. Journal of the American Heart Association, 2017 Dec 8;6(12)2017
Logue OC, George EM, Bidwell GL 3rd, Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia. Clinical science (London, England : 1979), 2016 Aug 1;130(16):1417-342016
Logue OC, McGowan JW, George EM, Bidwell GL 3rd, Therapeutic angiogenesis by vascular endothelial growth factor supplementation for treatment of renal disease. Current opinion in nephrology and hypertension, 2016 Sep;25(5):404-92016
Flanagan TW, Files JK, Casano KR, George EM, Brown DT, Photobleaching studies reveal that a single amino acid polymorphism is responsible for the differential binding affinities of linker histone subtypes H1.1 and H1.5. Biology open, 2016 Feb 24;5(3):372-802016
George EM, Mahdi F, Logue OC, Robinson GG, Bidwell GL 3rd, Corneal Penetrating Elastin-Like Polypeptide Carriers. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2016 Apr;32(3):163-712016
Warrington JP, Coleman K, Skaggs C, Hosick PA, George EM, Stec DE, Ryan MJ, Granger JP, Drummond HA, Heme oxygenase-1 promotes migration and β-epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas. American journal of physiology. Regulatory, integrative and comparative physiology, 2014 May;306(9):R641-62014
George EM, Garrett MR, Granger JP, Placental ischemia induces changes in gene expression in chorionic tissue. Mammalian genome : official journal of the International Mammalian Genome Society, 2014 Jun;25(5-6):253-612014
George EM, Warrington JP, Spradley FT, Palei AC, Granger JP, The heme oxygenases: important regulators of pregnancy and preeclampsia. American journal of physiology. Regulatory, integrative and comparative physiology, 2014 Oct 1;307(7):R769-772014
Chinthalapudi K, Rangarajan ES, Patil DN, George EM, Brown DT, Izard T, Lipid binding promotes oligomerization and focal adhesion activity of vinculin. The Journal of cell biology, 2014 Dec 8;207(5):643-562014
George EM, New approaches for managing preeclampsia: clues from clinical and basic research. Clinical therapeutics, 2014 Dec 1;36(12):1873-18812014
Hammond BR, Johnson BA, George ER, Oxidative photodegradation of ocular tissues: beneficial effects of filtering and exogenous antioxidants. Experimental eye research, 2014 Dec;129:135-502014
George EM, Liu H, Robinson GG, Bidwell GL, A polypeptide drug carrier for maternal delivery and prevention of fetal exposure. Journal of drug targeting, 2014 Dec;22(10):935-472014
Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira AS, Burke SD, George EM, Granger JP, Karumanchi SA, Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014 Oct;28(10):4324-342014
George EM, Granger JP, Heme oxygenase in pregnancy and preeclampsia. Current opinion in nephrology and hypertension, 2013 Mar;22(2):156-622013
George EM, Hosick PA, Stec DE, Granger JP, Heme oxygenase inhibition increases blood pressure in pregnant rats. American journal of hypertension, 2013 Jul;26(7):924-302013
George EM, Palei AC, Dent EA, Granger JP, Sildenafil attenuates placental ischemia-induced hypertension. American journal of physiology. Regulatory, integrative and comparative physiology, 2013 Aug 15;305(4):R397-4032013
Warrington JP, George EM, Palei AC, Spradley FT, Granger JP, Recent advances in the understanding of the pathophysiology of preeclampsia. Hypertension (Dallas, Tex. : 1979), 2013 Oct;62(4):666-732013
George EM, Arany I, Induction of heme oxygenase-1 shifts the balance from proinjury to prosurvival in the placentas of pregnant rats with reduced uterine perfusion pressure. American journal of physiology. Regulatory, integrative and comparative physiology, 2012 Mar 1;302(5):R620-62012
George EM, Palei AC, Granger JP, Endothelin as a final common pathway in the pathophysiology of preeclampsia: therapeutic implications. Current opinion in nephrology and hypertension, 2012 Mar;21(2):157-622012
George EM, Granger JP, Linking placental ischemia and hypertension in preeclampsia: role of endothelin 1. Hypertension (Dallas, Tex. : 1979), 2012 Aug;60(2):507-112012
Hall JE, Granger JP, do Carmo JM, da Silva AA, Dubinion J, George E, Hamza S, Speed J, Hall ME, Hypertension: physiology and pathophysiology. Comprehensive Physiology, 2012 Oct;2(4):2393-4422012
George EM, Cockrell K, Aranay M, Csongradi E, Stec DE, Granger JP, Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension. Hypertension (Dallas, Tex. : 1979), 2011 May;57(5):941-82011
Tam Tam KB, George E, Cockrell K, Arany M, Speed J, Martin JN Jr, Lamarca B, Granger JP, Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance. American journal of obstetrics and gynecology, 2011 Apr;204(4):330.e1-42011
George EM, Granger JP, Mechanisms and potential therapies for preeclampsia. Current hypertension reports, 2011 Aug;13(4):269-752011
Speed JS, LaMarca B, Berry H, Cockrell K, George EM, Granger JP, Renal medullary endothelin-1 is decreased in Dahl salt-sensitive rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2011 Aug;301(2):R519-232011
George EM, Granger JP, Endothelin: key mediator of hypertension in preeclampsia. American journal of hypertension, 2011 Sep;24(9):964-92011
George EM, Arany M, Cockrell K, Storm MV, Stec DE, Granger JP, Induction of heme oxygenase-1 attenuates sFlt-1-induced hypertension in pregnant rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2011 Nov;301(5):R1495-5002011
Ryan MJ, Gilbert EL, Glover PH, George EM, Masterson CW, McLemore GR Jr, LaMarca B, Granger JP, Drummond HA, Placental ischemia impairs middle cerebral artery myogenic responses in the pregnant rat. Hypertension (Dallas, Tex. : 1979), 2011 Dec;58(6):1126-312011
Hall ME, George EM, Granger JP, [The heart during pregnancy]. Revista espanola de cardiologia, 2011 Nov;64(11):1045-502011
George EM, Brown DT, Prothymosin alpha is a component of a linker histone chaperone. FEBS letters, 2010 Jul 2;584(13):2833-62010
George EM, Izard T, Anderson SD, Brown DT, Nucleosome interaction surface of linker histone H1c is distinct from that of H1(0). The Journal of biological chemistry, 2010 Jul 2;285(27):20891-62010
George EM, Cockrell K, Adair TH, Granger JP, Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants. American journal of physiology. Regulatory, integrative and comparative physiology, 2010 Dec;299(6):R1629-332010
George EM, Granger JP, Recent insights into the pathophysiology of preeclampsia. Expert review of obstetrics & gynecology, 2010 Sep 1;5(5):557-5662010
Hearst SM, Gilder AS, Negi SS, Davis MD, George EM, Whittom AA, Toyota CG, Husedzinovic A, Gruss OJ, Hebert MD, Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines. Journal of cell science, 2009 Jun 1;122(Pt 11):1872-812009
Meshorer E, Yellajoshula D, George E, Scambler PJ, Brown DT, Misteli T, Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Developmental cell, 2006 Jan;10(1):105-162006
Speed JS, George EM, Arany M, Cockrell K, Granger JP, Role of 20-hydroxyeicosatetraenoic acid in mediating hypertension in response to chronic renal medullary endothelin type B receptor blockade. PloS one, 2011;6(10):e26063
George EM, Colson D, Dixon J, Palei AC, Granger JP, Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin. International journal of hypertension, 2012;2012:486053
George EM, Stout JM, Stec DE, Granger JP, Heme oxygenase induction attenuates TNF-α-induced hypertension in pregnant rodents. Frontiers in pharmacology, 2015;6:165
George EM, Liu H, Robinson GG, Mahdi F, Perkins E, Bidwell GL 3rd, Growth factor purification and delivery systems (PADS) for therapeutic angiogenesis. Vascular cell, 2015;7(1):1
Bidwell GL 3rd, George EM, Maternally sequestered therapeutic polypeptides - a new approach for the management of preeclampsia. Frontiers in pharmacology, 2014;5:201

Review Article

Palei AC, Spradley FT, Warrington JP, George EM, and Granger JP Pathophysiology of Hypertension in Preeclampsia: A Lesson in Integrative Physiology Acta Physiol (Oxf). 2013 Apr 16. Epub ahead of print2013

Abstracts

Colson AS, DixonJ, George EM, and Granger JP Heme oxygenase-1 attenuates hypoxia-induced superoxide production in placental villi FASEB J March 17, 2011 25:836.92011
George EM, Cockrell K, Arany M, Stec DE, and Granger JP Heme oxygenase-1 induction attenuates sFlt-1 induced hypertension in pregnant rats FASEB J March 17, 2011 25:836.72011
George EM, Adair TH, and Granger JP Regulation of sFlt-1 secretion by adenosine receptor signaling in rat placental villous explants FASEB J, Apr 2010: 24: 1041.112010

Book Chapter

George EM and Granger JP Animal models for investigating pathophysiological mechanisms of preeclampsia In Lindheimer MD, Roberts JM, and Cunningham FG (Eds.), Chesley’s Hypertensive Disorders of Pregnancy, 4th Edition. Elsevier.2015
Granger JP and George EM Role of the Kidneys in Hypertension In Schrier RW, Coffman TM, Falk RJ, Molitoris BA, and Neilson EG. (Eds.), Schrier’s Diseases of the Kidney, 9th ed. Lippincott Williams & Wilkins.2012
George EM and Granger JP Vascular Mechanisms of Hypertension in the Pathophysiology of Preeclampsia In Hill, J.A., Griendling, K., and Olson, E.N. (Eds.), Muscle: Fundamental Biology and Mechanisms and Disease. Elsevier.2012

Editorial

George EM, Bidwell GL, STOX1: a new player in preeclampsia? Hypertension (Dallas, Tex. : 1979), 2013 Mar;61(3):561-32013

Presentations

National and International Invited Seminars/Lectures, Shedding of the Placental Glycocalyx in Response to Ischemia and Hypoxia., International Society for Hypertension in Pregnancy 2018, Amsterdam, The Netherlands10/2018
State/Local Invited Seminars/Lectures, Preeclampsia: Unanswered Questions and New Opportunities, UMMC Department of Physiology, Jackson, MS07/2018
National and International Invited Seminars/Lectures, Animal Models for Preeclampsia, Predicting, Preventing and Treating Preeclampsia Workshop. NIH., Bethesda Maryland03/2018
State/Local Invited Seminars/Lectures, Preeclampsia: Challenges and Opportunities, UMMC Department of Physiology, Jackson, MS06/2017
State/Local Invited Seminars/Lectures, The Placental Glycocalyx in Pregnancy and Preeclampsia, UMMC Department of Physiology, Jackson, MS05/2016
National and International Invited Seminars/Lectures, Extracellular Matrix Remodeling in the Etiology of Preeclampsia., Experimental Biology 2016, Boston, MA04/2016
State/Local Invited Seminars/Lectures, Novel anti-angiogenic therapies for ocular disorders, UMMC CRRC, Jackson, MS05/2015
State/Local Invited Seminars/Lectures, New Molecular Mechanisms in the Pathogenesis of Preeclampsia., UMMC Department of Pharmacology, Jackson, MS11/2014
National and International Invited Seminars/Lectures, Preeclampsia and Cardiovascular Disease., International Society for Hypertension 2014, Athens, Greece06/2014
State/Local Invited Seminars/Lectures, New Pathogenic Mechanisms in Preeclampsia, Department of Biochemistry, Jackson, MS10/2013
National and International Invited Seminars/Lectures, Transcriptomics of placental ischemia/new peptide therapies for preeclampsia, Tox Talx 2013, Mill Valley, CA06/2013
National and International Invited Seminars/Lectures, Hypoxia-induced Heparanase Regulates sFlt-1 Release from Placental Chorionic Villi, American Heart Association’s Council on High Blood Pressure Research 2012 Scientific Sessions, Washington, DC09/2012
National and International Invited Seminars/Lectures, Is HO-1 a potential therapeutic of pre-eclampsia, 7th International Congress on Heme Oxygenases and Related Enzymes, Edinburgh, Scotland05/2012
National and International Invited Seminars/Lectures, Heme Oxygenase-1 as a Potential Therapeutic Target for the Treatment of Preeclampsia, • APS Physiology of Cardiovascular Disease: Gender Disparities, Jackson MS10/2011
Invited Symposia, Heme Oxygenase-1 Negatively Regulates sFlt-1 Production in Placental Villi by its Metabolic Byproducts Carbon Monoxide and Bilirubin, American Heart Association, Council on High Blood Pressure Research, Orlando, FL09/2011
Invited Symposia, Heme oxygenase-1 induction attenuates sFlt-1 induced hypertension in pregnant rats, FASEB, Washington, DC04/2011
State/Local Invited Seminars/Lectures, New insights into the function of linker histones, • Engineer Research and Development Center, US Army Corps of Engineers, Visksburg, MS02/2011

Honors, Awards, and Recognition

University of Mississippi Medical Center Excellence in Research Award-Gold Medal, UMMC2018
APS Early Career Advocacy Fellowship, American Physiological Society2016
APS WEH New Investigator Award, American Physiological Society2015
University of Mississippi Medical Center Excellence in Research Award-Silver Medal, UMMMC2015
University of Mississippi Medical Center Excellence in Research Award – Bronze Medal, UMMC2014
HBPR Trainee Advocacy New Investigator Travel Award, American Heart Association2011
American Heart Association Hypertension Summer School Travel Award, American Heart Association2010

Professional Membership and Service

Society for Reproductive Investigation, Member2018 - Present
American Heart Association, Member2010 - Present
American Physiological Society, Member2009 - Present

Committee Service

AHA High Blood Pressure Council Leadership Committee Advocacy Representative, Steering Comittee Member2018 - Present
AHA Vascular Biology and Blood Pressure Fellowship Study Section, Member2018 - Present
University of Mississippi Medical Center Postdoctoral Advisory Committee, Member2015 - 2016
Trainee Advocacy Committee, APS Sex and Gender Research Interest Group, Steering Comittee Member2015 - Present
University of Mississippi Medical Center School of Graduate Studies in the Health Sciences Alumni Board of Directors, Member2013 - 2016
AHA Summer Undergraduate Fellowship Study Section, Member2012 - Present
Research Trainee Advisory Subcommittee for the AHA’s Council on High Blood Pressure, Member2010 - 2017

Other Service

AHA Vascular Biology and Blood Pressure Fellowship Study Section07/2018 - Present
Physiological Genomics05/2017 - Present
MSU Veterinary School Intramural Research Grant Review Panel07/2016 - 06/2017
Hypertension07/2015 - Present
Medical Research Council, United Kingdom2015 - Present
French National Research Agency2015 - Present
Italian National Research Agency2015 - Present
Obstetric and Pediatric Pharmacology2015 - Present
Intramural Research Support Program (IRSP) Reviewer2013 - Present
AHA Summer Undergraduate Research Fellowship Study Section07/2011 - Present
Reproduction, Fertility and Development
Redox Report
Frontiers in Pharmacology
Clinical Biochemistry
Journal of Molecular Histology
Experimental Physiology
PLOS ONE
Reproductive Sciences
Journal of Cardiovascular Pharmacology
Clinical and Experimental Hypertension
BioMed Research International
Current Molecular Medicine
Gynecology and Obstetrics: Current Research
Placenta
Biochemistry and Cell Biology
International Journal of Hypertension
European Journal of Obstetrics & Gynecology and Reproductive Biology
Clinical Sciences
American Journal of Hypertension
International Journal of Biological Sciences

Teaching Experience

PHYSIO611, Graduate, Course, Lecturer, Advanced EndocrinologyAnnual 2018
NSCI708, Graduate, Course, Guest Presenter, Special Topics in NeuroscienceSummer 2018
PHYSIO717, Graduate, Course, Lecturer, Circulatory PhysiologyFall 2017
PHYSIO611, Medicine, Lecture, Guest Presenter, Medical PhysiologySpring 2016
PHYSIO727, Graduate, Course, Lecturer, Physiological Applications of Molecular BiologyfAnnual 2015
ID709, Graduate, Course, Lecturer, Responsible Conduct of ResearchAnnual 2015 - 2016
PHYSIO725, Graduate, Lecture, Lecturer, Principles of PhysiologyAnnual 2014
PHYSIO611, Medicine, Small Group, Preceptor, Medical PhysiologyAnnual 2014
BCH740, Graduate, Lecture, Lecturer, Research Tools in Molecular BiologyAnnual 2013
PHYSIO625, Dentistry, Lecture, Lecturer, Principles of PhysiologyAnnual 2013

Directed Student Learning

Dissertation Committee Member, Advised: Subhi Younes2018 - Present
Dissertation Committee Member, Advised: Jason Engel2018 - Present
Dissertation Committee Member, Advised: Tyler Lomax2018 - Present
Supervised Research, Advised: Haley Murphy2018 - 2018
Dissertation Committee Chair, Advised: Kyle Moore2018 - Present
Dissertation Committee Member, Advised: Erika Guise2017 - Present
Dissertation Committee Member, Advised: Ashley Newsome2016 - 2018
Dissertation Committee Member, Advised: Marija Kuna2016 - 2018
Supervised Research, Advised: London Williams2016 - 2017
Dissertation Committee Chair, Advised: Adrian Eddy2016 - Present
Master's Thesis Committee Member, Advised: Jeremy McGowan2015 - 2017
Preceptor, Advised: William Stewart2015 - 2018
Supervised Research, Advised: Kevin Garman2014 - 2014
Supervised Research, Advised: Logan Wilson