John Clemmer, PhD

John Clemmer, PhD

Assistant Professor

Department:
SOM-Physiology & Biophysics

Email:
jclemmer@umc.edu

Work Phone:
(601) 984-1802

Education

University of Mississippi Medical Center, PhD, Physiology2015
Mississippi State, MS, Biomedical Engineering2010
Mississippi State, BS, Biological Engineering2008

Sponsored Program Funding

Extramural, Modeling physiological changes associated with aging, Brown Foundation12/2020 - 11/2021
Extramural, Improving Hypertension Treatment in African Americans Using Computational Modeling and Predictive Analytics, NIH09/2020 - 04/2022
Intramural, Simulation to Guide Implementation of Telemedicine Cardiorenal Interventions to Reduce Health Disparities, UMMC TeleHealth Center10/2019 - 04/2021
Extramural, Sycamore: A real-time simulation for continuity of care training, Hearin Foundation04/2019 - 03/2021
Extramural, Computational Modeling to Improve the Treatment of Resistant Hypertension, American Heart Association06/2017 - 05/2019
Extramural, Exaggerated Pulmonary Edema after Hemorrhage and Resuscitation in the Obese Zucker Rat, American Heart Association05/2014 - 04/2016

Publications

Journal Article

Clemmer JS, Pruett WA, Hester RL In silico trial of baroreflex activation therapy for the treatment of hypertension PLOS ONE. 16(11):e0259917, 20212021
Moore KH, Clemmer JS, Questioning the renoprotective role of L-type calcium channel blockers in chronic kidney disease using physiological modeling. American journal of physiology. Renal physiology, 2021 Oct 1;321(4):F548-F5572021
Clemmer JS, Pruett WA, Lirette ST Racial and sex differences in the response to antihypertensive monotherapy Front Cardiovasc Med. 17 (7):608037, 20202020
Pruett WA, Clemmer JS, Hester RL, Physiological Modeling and Simulation-Validation, Credibility, and Application. Annual review of biomedical engineering, 2020 Jun 4;22:185-2062020
Clemmer JS, Faulkner JL, Mullen AJ, Butler KR, Hester RL, Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females. Biology of sex differences, 2019 May 9;10(1):242019
Xiang L, Thompson MS, Clemmer JS, Mittwede PN, Khan T, Hester RL, Early treatment with GLP-1 after severe trauma preserves renal function in obese Zucker rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2019 May 1;316(5):R621-R6272019
Clemmer JS, Pruett WA, Hester RL, Lohmeier TE, Preeminent role of the cardiorenal axis in the antihypertensive response to an arteriovenous fistula: an in silico analysis. American journal of physiology. Heart and circulatory physiology, 2019 Nov 1;317(5):H1002-H10122019
Hester RL, Pruett W, Clemmer J, Ruckdeschel A, Simulation of integrative physiology for medical education. Morphologie : bulletin de l'Association des anatomistes, 2019 Dec;103(343):187-1932019
Clemmer JS, Pruett WA, Hester RL, Iliescu R, Lohmeier TE, Role of the heart in blood pressure lowering during chronic baroreflex activation: insight from an in silico analysis. American journal of physiology. Heart and circulatory physiology, 2018 Nov 1;315(5):H1368-H13822018
Clemmer JS, Hester RL, Pruett WA, Simulating a virtual population's sensitivity to salt and uninephrectomy. Interface focus, 2018 Feb 6;8(1):201601342018
Clemmer JS, Pruett WA, Coleman TG, Hall JE, Hester RL, Mechanisms of blood pressure salt sensitivity: new insights from mathematical modeling. American journal of physiology. Regulatory, integrative and comparative physiology, 2017 Apr 1;312(4):R451-R4662017
Blair ET, Clemmer JS, Harkey HL, Hester RL, Pruett WA, Physiologic Mechanisms of Water and Electrolyte Disturbances After Transsphenoidal Pituitary Surgery. World neurosurgery, 2017 Nov;107:429-4362017
Pruett WA, Clemmer JS, Hester RL, Validation of an integrative mathematical model of dehydration and rehydration in virtual humans. Physiological reports, 2016 Nov;4(22)2016
Clemmer JS, Xiang L, Lu S, Mittwede PN, Hester RL, Hyperglycemia-Mediated Oxidative Stress Increases Pulmonary Vascular Permeability. Microcirculation (New York, N.Y. : 1994), 2016 Apr;23(3):221-92016
Mittwede PN, Xiang L, Lu S, Clemmer JS, Hester RL, Oxidative stress contributes to orthopedic trauma-induced acute kidney injury in obese rats. American journal of physiology. Renal physiology, 2015 Jan 15;308(2):F157-632015
Clemmer JS, Xiang L, Lu S, Mittwede PN, Hester RL, β2-adrenergic regulation of stress hyperglycemia following hemorrhage in the obese Zucker rat. Physiological reports, 2014 Dec 1;2(12)2014
Lu S, Xiang L, Clemmer JS, Mittwede PN, Hester RL, Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels. Microcirculation (New York, N.Y. : 1994), 2014 Nov;21(8):754-602014
Xiang L, Lu S, Mittwede PN, Clemmer JS, Husband GW, Hester RL, β(2)-Adrenoreceptor blockade improves early posttrauma hyperglycemia and pulmonary injury in obese rats. American journal of physiology. Heart and circulatory physiology, 2014 Aug 15;307(4):H621-72014
Xiang L, Lu S, Mittwede PN, Clemmer JS, Hester RL, Inhibition of NADPH oxidase prevents acute lung injury in obese rats following severe trauma. American journal of physiology. Heart and circulatory physiology, 2014 Mar 1;306(5):H684-92014
Mittwede PN, Xiang L, Lu S, Clemmer JS, Hester RL, A novel experimental model of orthopedic trauma with acute kidney injury in obese Zucker rats. Physiological reports, 2013 Oct;1(5):e000972013
Lu S, Xiang L, Clemmer JS, Gowdey AR, Mittwede PN, Hester RL, Impaired vascular KATP function attenuates exercise capacity in obese zucker rats. Microcirculation (New York, N.Y. : 1994), 2013 Oct;20(7):662-92013

Presentations

National and International Invited Seminars/Lectures, Physiological modeling of hypertensive kidney disease in African Americans, Society for Mathematical Biology Meeting, Virtual06/2021
Invited Symposia, An in silico analysis using physiological models of hypertensive African Americans, American Physiological Society, Virtual Experimental Biology04/2021
State/Local Invited Seminars/Lectures, Racial and sex differences in the response to antihypertensive monotherapy, UMMC09/2020
Poster Presentation, Preeminent Role of the Cardiorenal Axis in the Antihypertensive Response to an Arteriovenous Fistula: An In Silico Analysis, AHA-Council on Hypertension, New Orleans, LA09/2019
Poster Presentation, In silico trial of baroreflex activation therapy for the treatment of resistant hypertension, FDA/BMES Frontiers Conference, Washington D.C.03/2019

Honors, Awards, and Recognition

Hypertension Scientific Sessions Poster Competition Award, AHA2019
Regions Outstanding Research Award, UMMC2015
Featured Topic Presentation Selection for Recent Advances in Obesity Research, American Physiological Society2015
Travel Award, International Academy of Cardiovascular Sciences2015
Young Investigator Award, Society for Experimental Biology and Medicine2014
Caroline tum Suden/Hellebrandt Professional Award, American Physiological Society2014

Professional Membership and Service

Society for Mathematical Biology, Member2020 - 2022
Society for Experimental Biology and Medicine, Member, Experimental Biology2013 - 2016
American Heart Association, Member2011 - 2022
American Physiological Society, Member2011 - 2022
Microcirculatory Society, Member2011 - 2015
BiomedicaL Engineering Society, Member2008 - 2014

Committee Service

Integrated Medical School Curriculum-Renal Section, Co-Chair2021 - 2023
APS Water and Electrolyte Homeostasis Section, Co-Chair2021 - 2022
Postdoctoral Advisory Committee, Member2019 - 2020
Associated Student Body Mentoring Committee, Chair2014 - 2015
SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-CURRICULUM, Member2013 - 2014

Community Service

UMMC Discover U, Volunteer08/2015 - 05/2018
Physiology Understanding (PhUn) Week, Volunteer08/2011 - 05/2020

Other Service

Review Editor for Frontiers in Physiology04/2020 - 12/2022

Teaching Experience

PHYSIO 744, Graduate, Course, Lecturer, Simulation of Physiological MechanismsSpring 2022
Medicine, Lab, Facilitator, Medical PhysiologySpring 2021
Medicine, Lab, Lecturer, Medical PhysiologyFall 2020
PHYSIO 701, Medicine, Lab, Lecturer, Medical PhysiologySpring 2019
PHYSIO 731, Graduate, Course, Lecturer, Renal and Body Fluid PhysiologySpring 2019
PHYSIO 717, Graduate, Course, Lecturer, Circulatory PhysiologyFall 2018
PHYSIO 715, Graduate, Course, Lecturer, Advanced EndocrinologySpring 2018
PT601, SHRP, Course, Lecturer, Physiologic Basis of Physical TherapyFall 2020