Yingjie Chen
Professor
Department:
SOM-Physiology & Biophysics
Email:
ychen2@umc.edu
Work Phone:
(601) 815-3987
Education
| University of Minnesota, PhD, Kinisiology/Exercise Physiology | 1999 |
| National Res Institute of Sports Science, MS, Exercise Physiology | 1991 |
| Neimonggu Medical School, BS, Medicine | 1986 |
| University of Minnesota Medical School, Postdoctoral fellow, Heart Failure Research | |
| The 1st Teaching Hospital, Neimonggu Medical University, Neurosurgen, Neurosurgery |
Current Positions
| Professor, School of Medicine | 08/2019 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Professor, Tongji University, School of Medicine | 07/2015 - 07/2019 |
| Associate Professor, University of Minnesota, School of Medicine, Department of Medicine | 07/2012 - 08/2019 |
| Assistant Professor, University of Minnesota, School of Medicine | 07/2005 - 06/2012 |
| Assistant Professor, University of Minnesota, School of Medicine | 07/2003 - 06/2005 |
| Assistant Professor, University of Minnesota, School of Medicine | 07/2001 - 06/2003 |
| Associate Professor, National Research Institute of Sports Science | 07/1993 - 08/1995 |
| Department Chair, National Research Institute of Sports Science | 07/1993 - 08/1995 |
| Assistant Professor, National Research Institute of Sports Science, School of Health Related Professions | 07/1991 - 06/1993 |
| Neurosurgen, N, School of Medicine | 07/1986 - 06/1988 |
Sponsored Program Funding
| Extramural, Mechanism of PD-1 in cardiomyopathy and heart failure progression, NIH | 04/2021 - 06/2026 |
| Extramural, Mechanisms of Treg and IL-35 in Regulating LV Failure-induced Lung Remodeling and Right Heart Hypertrophy, NIH | 09/2018 - 06/2022 |
| Extramural, CD44 in heart failure development and progression, American Heart Association | 07/2017 - 06/2019 |
| Extramural, Effect of eIF4E3 on congestive heart failure development, American Heart Association | 07/2015 - 06/2017 |
| Extramural, Molecular mechanism of 4E-binding proteins on heart failure development, NIH | 08/2011 - 06/2016 |
| Extramural, Regulation of the novel mTOR suppressor DDIT4 in the failing heart, NIH | 04/2011 - 12/2014 |
| Extramural, DDAH1 effects on endogenous NOS inhibitors and vascular endothelial function, NIH | 08/2010 - 06/2013 |
| Extramural, DDAH1 effects on the development of congestive heart failure, NIH | 04/2010 - 03/2012 |
| Extramural, AMP-activated protein kinase effects on ventricular hypertrophy and heart failure, American Heart Association | 07/2009 - 06/2011 |
| Extramural, Effect of endothelial DDAH1 gene deletion on the development of left ventricular dysfunction, American Heart Association | 07/2009 - 10/2011 |
| Extramural, Effect of NOS uncoupling on systolic overload-induced ventricular hypertrophy and congestive heart failure, American Heart Association | 07/2007 - 06/2009 |
| Extramural, Myocardial perfusion in the hypertrophied heart, NIH | 07/2006 - 06/2011 |
| Extramural, Myocardial perfusion in the hypertrophied heart | 05/2006 - 04/2010 |
| Extramural, Effect of TMX67 on aortic banding-induced ventricular hypertrophy and congestive heart failure, TAP Pharmaceutical Products | 01/2005 - 06/2006 |
| Extramural, Coronary Vascular Response to Ischemia, NIH | 07/2003 - 06/2008 |
| Extramural, Nitric Oxide and Superoxide Effects on the Failing Heart, NIH | 07/2003 - 06/2007 |
| Extramural, Effects of Nitric Oxide, Superoxide and Peroxynitrite on Myocardial Energy Metabolism in the Failing Heart, American Heart Association | 01/2003 - 12/2003 |
| Extramural, Effects of Nitric Oxide and Peroxynitrite on Energy Metabolism in the Failing Heart, American Heart Association | 07/2001 - 12/2002 |
| Extramural, Myocardial perfusion in the hypertrophied heart, NIH | 05/2001 - 04/2006 |
Publications
Journal Article | |
| Ping Zhang, Xin Xu, Xinli Hu, Huan Wang, John Fassett, Yuqing Huo, Yingjie Chen, Robert J Bache DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis | 2013 |
| Chen YJ, Guo QF. Delayed onset muscle damage J National Res Inst Sports Sci;1991;4:103-111 | 1991 |
| Huang YM, Chen YJ, Zhong W, Guo QF. The effects of strenuous exercise on blood viscosity and deformational ability of erythrocytes in rats J Chinese Sports Med 1996;15:230-233 | 1996 |
| Chen YJ, Guo QF. Free radical injury in exercise induced delayed onset muscle damage Chinese J Sports Med 1993;12:130-138. | 1993 |
| Chen YJ, Guo QF. Calcium overload in exercise induced delayed onset muscle damage Chinese J Sports Med 1992;11:133-141. | 1992 |
| Chen YJ, Guo QF, Zhao BL, Xin WJ. Electron spinal resonance studies on free radical metabolism of rats different fiber types during muscle fatigue. Chinese J Sports Med 1991;10:135-139. (The 1st author). | 1991 |
| Yingjie Chen Calcium in exercise J National Res Inst Sports Sci 1990;3:66-69. | |
Book Chapter | |
| Chen Y, Traverse J, Bache RJ Effect of PDE-5 inhibition on coronary blood flow in experimental animals. Page 163-177; Heart Disease and Erectile Dysfunction. Edt RA. Kloner. 2004 Human Press Inc. New Jersey. | 2004 |
| Chen YJ, Quo AF. Free radical injury in exercise induced delayed onset muscle damage--a primary study of mechanism of delayed onset muscle damage Sports, Medicine and Health. The Asian Perspective. Ed. K. M. Chan 1992, 135-140, Hong Kong. (The 1st author). | 1992 |
Presentations
| National and International Invited Seminars/Lectures, Overexpression of Alanine-Glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function, AHA Scientific Sessions | 11/2019 |
| National and International Invited Seminars/Lectures, Effect of air pollution and lung remodeling on the transition from left heart failure to right heart failure, The 30th GW-OCC, Beijing | 10/2019 |
| National and International Invited Seminars/Lectures, Effect of PM2.5 on the transition from left heart failure to right heart failure, The 13th OCC, Shanghai | 06/2019 |
| National and International Invited Seminars/Lectures, Cardiovascular risk factor ADMA in regulating heart failure development, The 13th OCC | 06/2019 |
| Regional Invited Seminars/Lectures, Role of Tregs in attenuating the transition from left heart failure to right heart failure, University of Minnesota, Minneapolis | 05/2019 |
| National and International Invited Seminars/Lectures, Short term PM2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy, 2019 EB Meeting, Orlando | 04/2019 |
| National and International Invited Seminars/Lectures, Effect of T cells on heart failure development and progression, EB Meeting, Orlando | 04/2019 |
| National and International Invited Seminars/Lectures, Effect of T cell activation on heart failure progression, The 29thth GW-OCC, Beijing | 10/2018 |
| National and International Invited Seminars/Lectures, Effect of lung remodeling on the transition from left heart failure to right heart failure, The 12th Oriental Congress of Cardiology, Shanghai | 06/2018 |
| National and International Invited Seminars/Lectures, Harnessing the T cell function as a new direction in attenuating the transition from left heart failure to right heart failure, The 12th Oriental Congress of Cardiology, Shanghai | 05/2018 |
| Poster Presentation, Effect of CD44 on the transition from left heart failure to right heart failure, University of Minnesota | 04/2018 |
| National and International Invited Seminars/Lectures, Harnessing the T cell function as a new direction in attenuating the transition from left heart failure to right heart failure, Keystone Heart Failure: Crossing the Translational Divide, Keystone, Keystone | 01/2018 |
| National and International Invited Seminars/Lectures, Inhibition of eukaryotic translation initiation factor 4E-3 (eif4E3) protects the heart against heart failure development, 11th Eleventh Oriental Congress of Cardiology, Shanghai | 06/2017 |
| National and International Invited Seminars/Lectures, Role of bone marrow-derived dendritic cells in pressure overload-induced cardiac inflammation and hypertrophy, 11th Eleventh Oriental Congress of Cardiology, Shanghai | 06/2017 |
| National and International Invited Seminars/Lectures, Transgenic Overexpression of Alanine-glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function, AHA ATVB, Minneapolis | 05/2017 |
| National and International Invited Seminars/Lectures, Cd44 Plays an Important Role in Regulating Heart Failure Induced Lung Vascular Remodeling and Who Type-2 Pulmonary Hypertension, AHA Arteriosclerosis, Thrombosis and Vascular Biology/Peripheral Vascular Disease 2017 Scientific Sessions | 05/2017 |
| National and International Invited Seminars/Lectures, Transgenic Overexpression of Alanine-glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function, 2016 AHA Scientific Sessions, New Orleans, Louisiana, USA | 11/2016 |
| National and International Invited Seminars/Lectures, The important role of lung remodeling in heart failure progression, The 20th GW-OCC, Beijing | 10/2016 |
| National and International Invited Seminars/Lectures, End-stage Heart Failure Causes Severe Lung Fibrosis and Dysfunction, Basic Cardiovascular Sciences 2016 Scientific Sessions, Phoenix | 07/2016 |
Honors, Awards, and Recognition
| Fellow of American Physiology Society, American Physiology Society | 2015 |
| Excellent service award, Academy of Cardiovascular Research Excellence | 2012 |
| Dr. Marvin and Hadassah Bacaner Research Award, University of Minnesota | 2008 |
| Lillehei Scholar, School of Medicine, University of Minnesota | 2005 |
| Dean's Faculty Recruit, School of Medicine, University of Minnesota | 2005 |
| Scientist Development Award, American Heart Association | 2003 |
| Distinguished Contribution Award, Chinese Olympic Comittee | 1992 |
| Honorable mention of Sports Science Award, President of International Olympic Committee | 1992 |
Professional Membership and Service
| Free Radical Biology Society, Member | 2019 - Present |
| American Physiology Society, Fellow | 2015 - Present |
| American Heart Association, Professional Membership | 2012 - Present |
| Academy of Cardiovascular Research Excellence, Fellow | 2003 - Present |
Committee Service
| Department of physiology graduate admissions committee, Member | 2020 - Present |
| Medical Student Research Committee, Member | 2020 - Present |
| Research mentoring committee, Member | 2018 - 2019 |
| American Heart Association Center Grant Review Committee, Member | 2017 - Present |
| American Heart Association Basic Sciences Peer Review Committee, Member | 2014 - 2019 |
| Academy of Cardiovascular Research Excellence, General Secretary | 2012 - 2016 |
| ACRE-cnAHA Cardiovascular Research Symposium, Organizing committee member or co-chair | 2011 - 2018 |
| International Academy of Cardiology, Scientific advisory board | 2010 - 2019 |
| International Academy of Cardiology, Member | 2010 - 2019 |
| LHI Cardio Ploozo, Member | 2010 - 2019 |
| LHI Summer Undergraduate Research Experience, Member | 2010 - 2019 |
| Department of Medicine Research Day, Judge | 2007 - 2019 |
Community Service
| American Heart Association, Grant reviewer | 05/2014 - 06/2019 |
| INTERNATIONAL ACADEMY OF CARDIOLOGY, abstract grading | 03/2012 - 07/2018 |
| The 16th International Academy of cardiology, abstract grading | 03/2011 - 05/2011 |
| International Society for Free Radical Research, Grading abstracts | 05/2010 - Present |
| Abstract grading for 15th International Academy of cardiology, Abstract grading | 03/2010 - 04/2010 |
| Grant review fro NIH, Grant Reviewer | 06/2006 - 10/2018 |
Other Service
| 2015 NIH SBIR/STTR grant review panel | 2018 - Present |
| 2018 Summer's Wish Pediatric Cardiology Innovators Fund, 2018 Summer's Wish Pediatric Cardiology Innovators Fund, University of Minnesota | 2018 - Present |
| American Heart Association, MOLECULAR SIGNALING & CELL TRANS 2 | 2018 - 06/2019 |
| NIH ZRG1 Grant peer review study section committee member, NIH ZRG1 Vascular and Hematology AREA Application Review Panel (VH) R15 | 2018 - Present |
| 2017 AHA Center grant review | 2017 - Present |
| 2017 NIH SBIR/STTR grant review pane | 2017 - Present |
| Grant peer review committee member, NIH | 06/2015 - Present |
| NIH CCHF study section | 06/2014 - Present |
| American Heart Association, Cell Signaling 3&4, American Heart Association, Cell Signaling 3&4 | 2014 - 12/2017 |
| 2018 NIH SBIR/STTR grant review | 2008 - Present |
| Grant reviewer, Reviewer for Research Grant Management Group | 2005 - 12/2007 |
| Reviewer for 46 journals, Reviewer for 46 journals: Antioxidants and Redox Signal; Arteriosclerosis, Thrombosis, and Vascular Biology; Atherosclerosis; American Journal of Physiology; Acta Pharmaceutica Sinica; Cardiovascular Therapy; Circulation; Circulation Research; Circulation---Heart Failure; Diabetes; European Journal of Heart Failure; Eur Respir J; Experimental Biology and Medicine; Evidence-Based Complementary and Alternative Medicine; Frontier Oncology; Frontier Physiology; Free Radical Biology and Medicine Heart Failure; Hypertension; Human Gene Therapies; Journal of the American College Cardiology; Journal of Clinical Investigation; JCI Insights; International Journal of Molecular Sciences; Journal of Physiology and Pharmacology; Journal of Cardiac Failure; Journal of Cardiovascular Translational Research; Journal of Molecular and Cellular Cardiology; Lab Investigation; JOVE; Molecular and Cellular Biochemistry (MCBI); Nature Protocols; Nature Communications; Naunyn-Schmiedeberg's Archives of Pharmacology; Nitric Oxide; Nutrition & Metabolism; Nutrition, Metabolism & Cardiovascular Diseases; Oxidative Medicine and Cellular Longevity; Proceedings of the National Academy of Sciences; PLoS ONE; Redox of Biology; Sport Science; The Journal of Experimental Medicine; Tongji Xuebao; Translational Research; Trends in Cardiovascular Medicine. | 07/2001 - 08/2020 |
| Nature Communications | |
| Nature Protocols | |
| Journal of Clinical Investigation | |
| Hypertension | |
| Diabetes | |
| Circulation Research | |
| Circulation | |
| Kentucky Medical Foundation, Grant reviewer for Kentucky Medical Foundation grant reviewer from 2005 to 2007 | |
| NIH NHLBI, Study Section of Exploratory Program in Systems Biology, NIH NHLBI, Study Section of Exploratory Program in Systems Biology | |
| Grant reviewer for NIH NHLBI, 2008 NHLBI, Exploratory Program in Systems Biology | |
| Reviewer for Minnesota Medical Foundation, 2018 academic year | |
| Grant peer review study section committee member, 2012, Indiana Medical Foundation grant reviewer |
Teaching Experience
| Medicine, Lecture, Lecturer, The Effect of T Cell Activation & Lung Inflammation on Heart Failure Development and Progression | Annual 2020 - 2020 |
| Medicine, Lecture, Lecturer, The role of T Cell Activation in Heart Failure Progression | Annual 2020 - 2020 |
| Lecture, Lecturer, The Effect of T Cell Activation & Lung Inflammation on Heart Failure Development and Progression | Annual 2020 - 2020 |
| Medicine, Small Group, Lecturer, The Important Role of CD44 in Heart Failure Development | Fall 2019 |
| Medicine, Lecture, Lecturer, Effect of Inflammation on the transition from left heart failure to right heart failure | Fall 2018 - 2018 |
Directed Student Learning
| Doctoral Advisory Committee Chair, Isolevuglandin effects on lung remodeling and the transition from left heart failure to right heart failure Advised: Lin Shang | 2017 - 2020 |
| Doctoral Advisory Committee Chair, Effect of T cells on heart failure development Advised: Dongzhi Wang | 2016 - 2019 |
| Internship Advisor, NA Advised: Liuqing Yang | 2015 - 2016 |
| Research Advisor, Effect of 4E3 on heart failure development Advised: Hailing Li | 2013 - 2014 |
| Research Advisor, NA Advised: Shuo Yan | 2012 - 2013 |
| Doctoral Advisory Committee Chair, DDAH1 effects on pulmonary hypertension development Advised: Dongmin Kwak | 2010 - 2016 |
| Research Advisor, Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase Advised: Dachun Xu | 2009 - 2011 |
| Research Advisor, Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3 Advised: Haipeng Guo | 2009 - 2011 |
| Doctoral Advisory Committee Member, Coronary blood flow regulation during heart failure development Advised: Xin Xu | 2003 - 2005 |
Fellows supervised
| Cardiovascular research, Post-Doc Advisor, 0 fellows supervised | 07/2006 - 06/2015 |
| Cardiovascular research, Post-Doc Advisor, 18 fellows supervised | 05/2003 - 08/2019 |
Residency Training
| Cardiovascular Division, Research Advisor | |
| Cardiovascular Division, Research Advisor | |
| Cardiovascular research, Research Advisor |