Brian Akerley, PhD
Associate Professor
Department:
SOM-Cell and Molecular Biology
Email:
bakerley@umc.edu
Work Phone:
(601) 815-1235
Education
| Harvard Medical School, Postdoctoral Training, Postdoc | 1999 |
| University of California, Los Angeles, PhD, Microbiology and Immunology | 1995 |
| Bates College, BS, Biology | 1988 |
Current Positions
| Associate Professor, School of Medicine, Department of Microbiology | 11/2013 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Michigan Medical School, School of Medicine, Department of Microbiology | 06/1999 - 07/2003 |
| Assistant Professor, University of Massachusetts Medical School, School of Medicine, Department of Medicine | 07/2003 - 11/2013 |
| Instructor, Harvard Medical School, School of Medicine, Department of Microbiology | 1999 - 06/1999 |
Sponsored Program Funding
| Extramural, A novel Th17-enhancing adjuvant and conserved antigen for protection against viral/bacterial co-infection, NIH NIAID | 04/2025 - 03/2027 |
| Extramural, Targeted delivery of novel miRNA-based therapeutics for pneumonia-induced acute lung injury, NIH NIAID | 09/2023 - 08/2024 |
| Extramural, The oxidation of heme-carrying proteins in the pathophysiology of pneumococcal disease, NIH/NIAID | 09/2023 - 08/2028 |
| Extramural, Mechanisms underlying adhesion and colonization in pneumococcal keratitis, NIH NEI | 07/2023 - 06/2025 |
| Extramural, Broadly protective multi-subunit vaccines against Haemophilus influenzae (SMART Business ACT award), State of Mississippi IHL | 03/2023 - 03/2025 |
| Extramural, “Hemoglobin-induced virulence in Streptococcus pneumoniae”, NIH/NIAID | 03/2021 - 02/2024 |
| Extramural, RO1 AI095740-01 (MPI: Akerley, Shen) "Mechanisms of Haemophilus influenzae pathogenesis in the lung" (Contact PI: Akerley), NIH/NIAID | 02/2012 - 01/2018 |
| Extramural, "Protein–protein interaction essential for bacterial growth and virulence" R21 (PI: Saper), Univ. of Michigan/NIH (NIAID) | 02/2012 - 01/2014 |
| Extramural, R56 "Mechanisms of Haemophilus influenzae pathogenesis in the lung"(PI: Akerley), NIH/NIAID | 07/2011 - 02/2012 |
| Extramural, "Global Regulatory Interactions in Bacterial Pathogenesis" R56 (PI: Akerley), NIH/NIAID | 09/2009 - 08/2010 |
| Extramural, “Genome-scale genetic deletion system for virulent Y. pestis” (PI: Akerley), NERCE/NIH NIAID (Harvard U54 subaward) | 07/2005 - 06/2008 |
| Extramural, "Signaling Responses by Haemophilus influenzae During Stages of Infection" Scientist Development Grant (PI: Akerley), American Heart Association | 07/2002 - 06/2006 |
| Extramural, RO1 "Global Regulatory Interactions in Bacterial Pathogenesis" (PI:Akerley), NIH/NIAID | 06/2002 - 05/2008 |
| Extramural, “Genetic Mechanisms of H. influenzae Pathogenesis in a Model of Respiratory Tract Infection” (PI: Akerley), Philip Morris Inc. | 06/2002 - 12/2006 |
| Extramural, Adaptation to Anaerobiosis During H. influenzae Pathogenesis (NRSA R. Tyler), NIH NIDCD | 05/2002 - 04/2004 |
| Extramural, Identification of Strain-Specific Virulence Factors in Haemophilus influenzae (N. Bergman, Postdoc fellowship), PhRMA | 01/2002 - 12/2002 |
Publications
Journal Article | |
| Li, Y., Yang, Y., Chen, D., Wang, Y., Zhang, X., Li, W., Chen, S., Wong, S.M., Shen, M., Akerley, B.J.*, Shen, H.*. Memory Th17 cell-mediated protection against lethal secondary pneumococcal pneumonia following influenza infection mBio. 2023 May 24:e0051923. *co-corresponding author | 2023 |
| Wong, S.M., Gawronski, J., Akerley, B.J. Copper efflux system required in murine lung infection by Haemophilus influenzae composed of a canonical ATPase gene and tandem chaperone gene copies. Infect Immun. 2023 May 16;91(5):e0009123 | 2023 |
| Zhang, X., Yang, Y., Chen, S., Li, W., Li, Y., Akerley, B.J., Shao, L., Zhang, W., Shen, H., Abt, M.C. Antigen-specific memory TH17 cells promote cross-protection against Nontypeable Haemophilus influenzae following mild influenza A virus infection. Mucosal Immunol. 2023 Apr;16(2):153-166. | 2023 |
| Vidal, J.E., Wier, M.N., A. Angulo-Zamudio, U., McDevitt, E., Jop Vidal, A.G., Alibayov, B., Scasny, A., Wong, S.M., Akerley, B.J., McDaniel, L.S. Prophylactic Inhibition of Colonization by Streptococcus pneumoniae with the Secondary Bile Acid Metabolite Deoxycholic Acid Infect Immun. 2021; 89(12):e0046321. | 2021 |
| Jackson, M.D., Wong, S.M., Akerley, B.J. Sialic acid protects nontypeable Haemophilus influenzae from natural IgM and promotes survival in murine respiratory tract Infect Immun.2021; 89(6):e00676-20. | 2021 |
| Benton AH, Jackson MD, Wong SM, Dees JL, Akerley BJ, Marquart ME A Transcriptional Activator of Ascorbic Acid Transport in Streptococcus pneumoniae Is Required for Optimal Growth in Endophthalmitis in a Strain-Dependent Manner Microorganisms. 2019 Aug 24;7(9). pii: E290. doi: 10.3390/microorganisms7090290 | 2019 |
| Jackson MD, Wong SM, Akerley BJ Underlying glycans determine the ability of sialylated lipooligosaccharide to protect nontypeable Haemophilus influenzae from serum IgM and complement Infect Immun. 2019 Aug 12. pii: IAI.00456-19. doi: 10.1128/IAI.00456-19 | 2019 |
| Wong SM, Jackson MD, Akerley BJ. Suppression of Alternative Lipooligosaccharide Glycosyltransferase Activity by UDP-Galactose Epimerase Enhances Murine Lung Infection and Evasion of Serum IgM Front Cell Infect Microbiol. 2019 May 15;9:160. doi: 10.3389/fcimb.2019.00160. | 2019 |
| Li W, Zhang X, Yang Y, Yin Q, Wang Y, Li Y, Wang C, Wong SM, Wang Y, Goldfine H, Akerley BJ*, Shen H*. Recognition of conserved antigens by Th17 cells provides broad protection against pulmonary Haemophilus influenzae infection Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7149-E7157. (*co-corresponding authors) | 2018 |
| Wong SM, Shaughnessy J, Ram S, Akerley BJ. Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae Front Cell Infect Microbiol. 2016 Apr 13;6:40. | 2016 |
| Rosadini CV, Ram S, Akerley BJ Outer membrane protein P5 is required for resistance of nontypeable Haemophilus influenzae to both the classical and alternative complement pathways Infect Immun. 2014 Feb;82(2):640-9 | 2014 |
| Wong SM, Bernui M, Shen H, Akerley BJ. Genome-wide fitness profiling reveals adaptations required by Haemophilus in coinfection with influenza A virus in the murine lung Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15413-8. (recommended in F1000Prime) | 2013 |
| Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog. 2011 Sep;7(9):e1002251. (cited >1000 times. Recommended in F1000Prime) | 2011 |
| Rosadini CV, Gawronski JD, Raimunda D, Argüello JM, Akerley BJ. A novel zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae in a murine lung infection model. Infect Immun. 2011 Aug;79(8):3366-76. | 2011 |
| Wong SM, St Michael F, Cox A, Ram S, Akerley BJ. ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae. Infect Immun. 2011 May;79(5):1971-83. | 2011 |
| Gawronski JD, Wong SM, Giannoukos G, Ward DV, Akerley BJ. Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16422-7. (Cited >380 times and in 4 patents. Featured in Future Microbiology; 5(2):313-328 and in Nature 461:1177) | 2009 |
| Harrington JC, Wong SM, Rosadini CV, Garifulin O, Boyartchuk V, Akerley BJ. Resistance of Haemophilus influenzae to reactive nitrogen donors and gamma interferon-stimulated macrophages requires the formate-dependent nitrite reductase regulator-activated ytfE gene Infect Immun. 2009 May;77(5):1945-58. | 2009 |
| Vijayalakshmi J, Akerley BJ, Saper MA Structure of YraM, a protein essential for growth of Haemophilus influenzae Proteins. 2008 Oct;73(1):204-17. | 2008 |
| Rosadini CV, Wong SM, Akerley BJ The periplasmic disulfide oxidoreductase DsbA contributes to Haemophilus influenzae pathogenesis Infect Immun. 2008 Apr;76(4):1498-508. | 2008 |
| Wong SM, Alugupalli KR, Ram S, Akerley BJ The ArcA regulon and oxidative stress resistance in Haemophilus influenzae Mol Microbiol. 2007 Jun;64(5):1375-90 | 2007 |
| Wong SM, Akerley BJ. Environmental and genetic regulation of the phosphorylcholine epitope of Haemophilus influenzae lipooligosaccharide Mol Microbiol. 2005 Feb;55(3):724-38 | 2005 |
| Raghunathan A, Price ND, Galperin MY, Makarova KS, Purvine S, Picone AF, Cherny T, Xie T, Reilly TJ, Munson R Jr, Tyler RE, Akerley BJ, Smith AL, Palsson BO, Kolker E. In Silico Metabolic Model and Protein Expression of Haemophilus influenzae Strain Rd KW20 in Rich Medium OMICS. 2004 Spring;8(1):25-41 | 2004 |
| Wong SM, Akerley BJ Inducible expression system and marker-linked mutagenesis approach for functional genomics of Haemophilus influenzae Gene. 2003 Oct 16;316:177-86. (handling editor: Allan M. Campbell) | 2003 |
| Bergman NH, Akerley BJ. Position-based scanning for comparative genomics and identification of genetic islands in Haemophilus influenzae type b Infect Immun. 2003 Mar;71(3):1098-108 | 2003 |
| Kolker E, Purvine S, Picone A, Cherny T, Akerley BJ, Munson RS Jr, Palsson BO, Daines DA, Smith AL H. influenzae Consortium: integrative study of H. influenzae-human interactions OMICS. 2002;6(4):341-8 | 2002 |
| Akerley BJ, Rubin EJ, Novick VL, Amaya K, Judson N, Mekalanos JJ. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):966-71. (cited > 470 times) | 2002 |
| Georgellis D, Kwon O, Lin EC, Wong SM, Akerley BJ. Redox signal transduction by the ArcB sensor kinase of Haemophilus influenzae lacking the PAS domain J Bacteriol. 2001 Dec;183(24):7206-12 | 2001 |
| Hendrixson DR, Akerley BJ, DiRita VJ. Transposon mutagenesis of Campylobacter jejuni identifies a bipartite energy taxis system required for motility Mol Microbiol. 2001 Apr;40(1):214-24 (cited >250 times) | 2001 |
| Lampe DJ, Akerley BJ, Rubin EJ, Mekalanos JJ, Robertson HM Hyperactive transposase mutants of the Himar1 mariner transposon Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11428-33. (cited >320 times) | 1999 |
| Rubin EJ*, Akerley BJ*, Novik VN, Lampe DJ, Husson RN, Mekalanos JJ In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4): 1645–1650 (*equal contributions; cited > 450 times) | 1999 |
| Cotter PA, Yuk MH, Mattoo S, Akerley BJ, Boschwitz J, Relman DA, Miller JF. Filamentous hemagglutinin of Bordetella bronchiseptica is required for efficient establishment of tracheal colonization Infect Immun. 1998 Dec;66(12):5921-9 | 1998 |
| Akerley BJ, Rubin EJ, Camilli A, Lampe DJ, Robertson HM, Mekalanos JJ. Systematic identification of essential genes by in vitro mariner mutagenesis Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8927-32. (cited >360 times and by 13 patents) | 1998 |
| Martinez de Tejada G1, Cotter PA, Heininger U, Camilli A, Akerley BJ, Mekalanos JJ, Miller JF. Neither the Bvg- phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice Infect Immun. 1998 Jun;66(6):2762-8 | 1998 |
| Giardina PC, Foster LA, Musser JM, Akerley BJ, Miller JF, Dyer DW Repression of alcaligin synthesis in Bordetella bronchiseptica is associated with phylogenetic lineage. J Bacteriol. 1995 Nov;177(21):6058-63 | 1995 |
| Akerley BJ, Cotter PA, Miller JF Ectopic expression of the flagellar regulon alters development of the Bordetella-host interaction Cell. 1995 Feb 24;80(4):611-20. (cited >330 times. featured in Current Biology 1995; July 1;5(7)706-9) | 1995 |
| Akerley BJ, Miller JF Flagellin gene transcription in Bordetella bronchiseptica is regulated by the BvgAS virulence control system J Bacteriol. 1993 Jun;175(11):3468-79 | 1993 |
| Akerley BJ, Monack DM, Falkow S, Miller JF. The bvgAS locus negatively controls motility and synthesis of flagella in Bordetella bronchiseptica J Bacteriol. 1992 Feb;174(3):980-90 | 1992 |
| Pollack S1, Ledbetter JA, Katz R, Williams K, Akerley B, Franklin K, Schieven G, Nel AE. Evidence for involvement of glycoprotein-CD45 phosphatase in reversing glycoprotein-CD3-induced microtubule-associated protein-2 kinase activity in Jurkat T-cells Biochem J. 1991 Jun 1;276 ( Pt 2):481-5. | 1991 |
| Nel, A.E., Ledbetter, J. A, Williams, K., Ho, P., Akerley, B., Franklin, K., and R. Katz. Activation of MAP-2 Kinase Activity by the CD2 Receptor in Jurkat T Cells can be Reversed by CD45 Phosphatase. Immunology. 73:129-133 | 1991 |
| Nel AE, Pollack S, Landreth G, Ledbetter JA, Hultin L, Williams K, Katz R,Akerley B. CD-3-mediated activation of MAP-2 kinase can be modified by ligation of the CD4 receptor. Evidence for tyrosine phosphorylation during activation of this kinase. J. Immunol. 145: 971-979. | 1990 |
Review Article | |
| Wong SM, Akerley BJ. Genome-scale approaches to identify genes essential for Haemophilus influenzae pathogenesis Front Cell Infect Microbiol. 2012 Mar 5;2:23. doi: 10.3389/fcimb.2012.00023. | 2012 |
| Akerley BJ, Miller JF Understanding signal transduction during bacterial infection Trends Microbiol. 1996 Apr;4(4):141-6 | 1996 |
Book Chapter | |
| Wong, S.M.S. and B. J. Akerley. Coordinate Regulation of Stress and Virulence Adaptations in Stages of Haemophilus Pathogenesis In S. Kidd. (ed.) Stress Responses in Pathogenic Bacteria. CABI International. Advances in Molecular and Cellular Microbiology. 2011. Oxfordshire, UK. | 2011 |
| Wong SM, Gawronski JD, Lapointe D, Akerley BJ High-throughput insertion tracking by deep sequencing for the analysis of bacterial pathogens Methods Mol Biol. 2011;733:209-22. doi: 10.1007/978-1-61779-089-8_15 | 2011 |
| Wong SM, Akerley BJ Identification and analysis of essential genes in Haemophilus influenzae Methods Mol Biol. 2008;416:27-44. doi: 10.1007/978-1-59745-321-9_3. (featured on cover) | 2008 |
| Akerley BJ, Lampe DJ Analysis of gene function in bacterial pathogens by GAMBIT Methods Enzymol. 2002;358:100-8 | 2002 |
| Cotter, P. A., Akerley, B., and J. F. Miller BvgAS Dependent Phenotypic Modulation of Bordetella Species. In:R. Rappuoli, V. Scarlato, and B. Arico (eds) Signal Transduction and Bacterial Virulence Austin: R. G. Landes Co., 21-34. (featured on cover) | 1995 |
Editorial Commentary | |
| Akerley BJ No-Go Zones for Mariner Transposition MBio. 2016 Oct 11;7(5). pii: e01690-16. | 2016 |
| De Wulf P, Akerley BJ, Lin EC Presence of the Cpx system in bacteria Microbiology. 2000 Feb;146 ( Pt 2):247-8 | 2000 |
Presentations
| Regional Invited Seminars/Lectures, Bacterial Immune Evasion in the Lungs of Healthy and Virally Infected Hosts: Mechanisms and Countermeasures, Dept. of Microbiol. & Immunol. & Parasitol. & Louisianna Vaccine Ctr., Louisiana State Univ. | 03/2024 |
| Poster Presentation, Deletion of genes mediating LOS and outer-membrane biogenesis in Haemophilus influenzae confers sensitivity to clarithromycin in a resistant background., South Central Am. Soc. for Microbiology, Little Rock, AR | 11/2023 |
| State/Local Invited Seminars/Lectures, Evasion of Antimicrobial Immune Responses by Haemophilus influenzae, Dept. of Cell and Molecular Biology, UMMC | 06/2023 |
| State/Local Invited Seminars/Lectures, Evasion of Antimicrobial Immune Responses by Haemophilus influenzae, Dept. of Cell and Molecular Biology, Table 100, Flowood, MS | 01/2023 |
| Poster Presentation, Uncovering immune targets of Haemophilus influenzae concealed by sialic acid., Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. | 09/2019 |
| State/Local Invited Seminars/Lectures, Development of immunotherapeutic factor H-Fc fusion proteins against Haemophilus influenzae, Mississippi IDeA Conference, Hilton Jackson in Jackson, MS | 08/2019 |
| invention description presentation, Developing a vaccine against nontypeable Haemophilus influenzae, Intellectual Property Committee, UMMC | 07/2019 |
| Poster Presentation, Clarithromycin resistance genes in the Haemophilus influenzae core genome, South Central Branch Am. Society for Microbiology Conference, UMMC | 11/2018 |
| Poster Presentation, Mechanisms of Sialic Acid in Complement Evasion by Nontypeable Haemophilus influenzae, South Central Branch Am. Society for Microbiology Conference, UMMC | 11/2018 |
| Poster Presentation, Suppression of alternative lipooligosaccharide glycosyltransferase activity by UDP-Galactose Epimerase enhances murine lung infection and evasion of serum antibody., South Central Branch Am. Society for Microbiology Conference, UMMC | 11/2018 |
| Poster Presentation, Mechanisms of Sialic Acid in Complement Evasion by Nontypeable Haemophilus influenzae., School of Graduate Studies in the Health Sciences Research Day, UMC | 10/2018 |
| Poster Presentation, Construction and Validation of a Transposon Insertion Library in a Pneumococcal Ocular Isolate, UMMC Rsearch Day, UMMC | 10/2017 |
| Regional Invited Seminars/Lectures, Breaking Codes and Countermeasures of Bacterial Immune Evasion (U. Kentucky), Dept. of Microbiology and Immunology, University of Kentucky, Louisville, KY | 09/2016 |
| Poster Presentation, Pneumococcal Genes Indicated for Fitness in the Vitreous Humor, American Soc. for Microbiology, Boston, MA | 06/2016 |
| Regional Invited Seminars/Lectures, A fastidious bacterium’s guide to survival in healthy and virally infected lungs (SPS meeting), Southeastern Pneumococcal Symposium, Starkville, MS | 05/2016 |
| Regional Invited Seminars/Lectures, Defining genetic networks in bacterial pathogenesis by single-molecule transposon insertion sequencing (UPenn), University of Pennsylvania, Department of Microbiology and Immunology, Philadelphia, PA | 11/2015 |
| State/Local Invited Seminars/Lectures, Bacterial Pneumonia in an Influenza Coinfection Model: Pathogenic Mechanisms and Antimicrobial Targets Revealed by Single-Molecule Transposon Insertion Sequencing (UMMC, CMB), Department of Cell and Molecular Biology, UMMC, Jackson, MS | 04/2015 |
| Regional Invited Seminars/Lectures, Bacterial adaptations in lung colonization and viral co-infection revealed by genome-scale approaches (Texas A+M), Microbial and Molecular Pathogenesis Annual Retreat, College of Medicine at the Texas A+M Health Science Center, College Station, TX | 04/2014 |
| Regional Invited Seminars/Lectures, Bacterial Adaptations in Lung Colonization and Viral Co-Infection Revealed by Genome-Scale Approaches (UAB), Department of Microbiology and Immunology, University of Alabama, Birmingham, AL | 08/2013 |
| Regional Invited Seminars/Lectures, Behind every successful bacterium is a good virus: H.influenzae partners with Flu in the pandemic business (HMS), Mekalanos Lab Anniversary Retreat, Harvard Medical School, Harvard Medical School, Boston, MA | 07/2012 |
| Regional Invited Seminars/Lectures, Boston Conference on Microbial Biology, Pathogenicity and Immunity. (HMS), Harvard Medical School, Boston, MA. | 2012 |
| Regional Invited Seminars/Lectures, Understanding pathogenesis of Hemophilus influenzae using genomic approaches (Dartmouth Medical School), Department of Microbiology and Immunology, Dartmouth Medical School, Department of Microbiology and Immunology, Hanover, NH | 11/2011 |
| Regional Invited Seminars/Lectures, Molecular Pathogenesis of Haemophilus influenzae in the lung (Penn State, Huck Institute), Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA | 09/2010 |
| National and International Invited Seminars/Lectures, "Genome-based approaches to understand bacterial pathogens and host defense", ASM 110th Annual Meeting, San Diego, ASM 110th Annual Meeting, San Diego, CA | 05/2010 |
| Regional Invited Seminars/Lectures, Genome Sequence-Based Approaches to Bacterial Pathogenesis and Monitoring Transposon ‘HITS’ in Mutant Libraries During Infection (Tufts), Tufts University Medical School, Tufts University Medical School, Department of Molecular Biology and Microbiology, Boston, MA. | 10/2008 |
| Poster Presentation, Genome Scale Deletion System for Yersinia pestis, Assumption College, Assumption College, Worcester, MA | 04/2008 |
| State/Local Invited Seminars/Lectures, Factors in complement resistance of Haemophilus influenzae, Boston Univ. SOM, Department of Pediatric Infectious Diseases, Boston University School of Medicine, Boston, MA | 04/2008 |
| Regional Invited Seminars/Lectures, Haemophilus influenzae: a persistent scavenger that eludes surveillance and resists arrest by antibacterial immunity (Dartmouth), Dartmouth Medical School, Dartmouth Medical School, Department of Microbiology and Immunology, Hanover, NH. | 01/2008 |
| National and International Invited Seminars/Lectures, High-throughput genetic deletion system for Yersinia pestis, Fourth Annual Regional Centers for Excellence National Meeting, St. Louis, MO | 2007 |
| Regional Invited Seminars/Lectures, Boston Microbial Pathogenesis Seminar Series, Harvard Medical School, Boston, MA | 01/2004 |
| State/Local Invited Seminars/Lectures, Genomic Approaches to Understanding Haemophilus influenzae Pathogenesis, Department of Molecular Genetics and Microbiology Seminar Series, University of Massachusetts Medical School, Worcester, MA | 09/2002 |
| Regional Invited Seminars/Lectures, Divisional Group Symposium, American Society for Microbiology 102cnd General Meeting, Salt Lake City, UT | 05/2002 |
| Regional Invited Seminars/Lectures, Bad Bug Club Seminar Series (MSU), Michigan State University, East Lansing, MI | 05/2002 |
| Regional Invited Seminars/Lectures, Essential Gene Identification for Therapeutic Target Discovery (Pfizer International), Pfizer Inc., Ann Arbor, MI | 02/2002 |
| State/Local Invited Seminars/Lectures, Haemophilus influenzae: A Model Organism for Functional Genomics of Bacterial Pathogens, University of Michigan Medical School, Nephrology Division Basic Science Seminar., Ann Arbor, MI | 05/2001 |
| Regional Invited Seminars/Lectures, Genome-scale Analysis of Genes Critical for Growth and Survival in Haemophilus influenzae, Institute for Molecular Pathogenesis and Therapeutics, and Dept. of Microbiology and Immunology, College Station, TX | 2001 |
| National and International Invited Seminars/Lectures, Functional Genomics for Understanding Haemophilus Biology and Pathogenesis, Institute for Molecular Pathogenesis and Therapeutics and The Department of Medical Microbiology and Immunology. Texas A&M University, College Station, TX | 2001 |
| Regional Invited Seminars/Lectures, One Small Step in Global Analysis of Bacterial Gene Function, Seventh Annual Midwest Microbial Pathogenesis Meeting. Children’s Research Institute, Ohio State University, Columbus, OH. | 10/2000 |
| National and International Invited Seminars/Lectures, Genes, Tissues, Bugs, and Bytes, Eight Annual MBC Biotechnology Symposium, Museum of Science, Boston, MA | 06/1999 |
| State/Local Invited Seminars/Lectures, Circumnavigating a Bacterial Genome with a Eukaryotic Mariner (UMich), Microbiology and Immunology Departmental Seminar Series, University of Michigan, Ann Arbor | 04/1999 |
| State/Local Invited Seminars/Lectures, Systematic Analysis of Essential Genes and Microbial Pathogenesis by in vitro mariner Mutagenesis (UPenn), Prokaryotic Seminar Series. University of Pennsylvania Medical School, University of Pennsylvania, Philadelphia, PA | 05/1998 |
| National and International Invited Seminars/Lectures, The BvgAS controlled motility regulon in Bordetella, 94th Annual American Society for Microbiology General Meeting, Los Vegas, NV | 05/1994 |
| National and International Invited Seminars/Lectures, BvgAS Controls the Motility Regulon of Bordetella bronchiseptica, 93rd Annual American Society for Microbiology General Meeting, Atlanta, Georgia | 05/1993 |
Honors, Awards, and Recognition
| US Patent #11,357,845: PROTEIN ANTIGENS FOR VACCINATING AGAINST NONTYPEABLE HAEMOPHILUS INFLUENZAE, US Patent Office | 2022 |
| Inventor Award, UMMC | 2019 |
| Research Excellence Award (Gold), University of Mississippi Medical Center | 2016 |
| Research Excellence Award (Silver), University of Mississippi Medical Center | 2015 |
| Research Excellence Award (Bronze), University of Mississippi Medical Center | 2014 |
| U.S. Patent# 7,838,502 B2. Compositions and Methods to Modulate H. influenzae pathogenesis., US Patent Office | 2010 |
| U.S. patent #6,368,830. Hyperactive Mutants of Himar1 Transposase and Methods for Making Same, US Patent Office | 2002 |
| American Heart Association Scientist Development Award, American Heart Association | 2002 |
| U.S. Patent# 6,207,384. Systematic Identification of Essential Genes by in vitro Transposon Mutagenesis., US Patent Office | 2001 |
| Dade Microscan Young Investigator Award, Am. Soc. for Microbiology | 2000 |
| Biological Sciences Scholars Award, University of Michigan | 1999 |
| Helen-Hay Whitney Postdoctoral Fellowship (declined), Helen-Hay Whitney Foundation | 1996 |
| Damon Runyon-Walter Winchell Postdoctoral Fellowship, Damon-Runyon Cancer Research Foundation | 1996 |
| Microbial Pathogenesis Training Grant, NIH NIAID/UCLA | 1992 |
| Tumor Immunology Training Grant, NIH/National Cancer Institute/UCLA | 1989 |
| National Merit Scholarship, National Merit Scholarship | 1984 |
Professional Membership and Service
| NIH NIAID, ad-hoc reviewer, LCMI study section | 2024 |
| NIH NIAID, ad-hoc reviewer, LCMI study section | 2023 |
| mBio, guest editor | 2019 |
| Mississippi State University, ad hoc grant reviewer, CVM ORGS Internal Grants Program | 2017 |
| NIH NIAID, ad hoc grant reviewer, NIH Lung Cellular, Molecular, and Immunobiology Study Section | 2017 |
| Infection and Immunity, Editorial Board Member | 2017 - Present |
| Frontiers in Cellular and Infection Microbiology, Associate Editor | 2015 - Present |
| NIH NIAID, ad hoc grant reviewer, NIH Host Interaction with Bacterial Pathogens (HIBP) study section | 2015 |
| GENETICS, ad hoc reviewer | 2014 - Present |
| NIH NIAID, ad-hoc grant reviewer, LCMI study section | 2014 |
| Journal of Bacteriology, Editorial Board Member | 2013 - 2022 |
| PLoS Pathogens, Guest editor | 2011 - 2012 |
| Institute for Drug Resistance, Member | 2009 - 2013 |
| American Heart Association Grant Review Panel, Member, Microbiology Grant Review Panel | 2008 - 2009 |
| NIH New England Regional Centers of Excellence Review Panel, ad hoc grant reviewer, NERCE Developmental Grant Review Panel | 2006 |
| NIH Oral, Dental and Craniofacial Sciences, ad hoc grant reviewer, Special Emphasis Panel/Scientific Review Group | 2006 |
| NIH NIGMS Consortium for Functional Glycomics, Member, Consortium for Functional Glycomics | 2006 - Present |
| NIH Oral, Dental and Craniofacial Sciences, ad hoc grant reviewer, Special Emphasis Panel/Scientific Review Group | 2005 |
| NIH NIDCD, ad hoc grant reviewer, NIDCD special emphasis panel. "Otitis Media: New Approaches" | 2004 |
| NIH NIDCD, ad hoc grant reviewer, NIDCD special emphasis panel. "Otitis Media: New Approaches." | 2003 |
| NIH NIDCD, ad hoc grant reviewer, NIDCD special emphasis panel. "Hearing and Balance Feasibility Grants." | 2002 |
| NIH NIDCD, ad hoc grant reviewer, NIDCD special emphasis panel. "Otitis Media: New Approaches." | 2002 |
| BIATECH, Seattle, Washington, Member, Haemophilus influenzae Consortium | 2002 - 2006 |
| Proc. National Academy of Sciences, ad hoc reviewer | 1999 - Present |
| GENE, Microbiology, BMC Genomics, Molecular Microbiology, ad hoc reviewer | 1999 - Present |
| Frontiers in Immunology, Nature Biotechnology, Gut Microbes, ad hoc reviewer | 1999 - Present |
| Cellular Microbiology, Antioxidants and Redox Signalling, ad hoc reviewer | 1999 - Present |
| American Society for Microbiology, Member | 1992 - Present |
Committee Service
| Intellectual Property Education Subcommittee, Chair | 2023 - Present |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-GRADUATE COUNCIL, Member | 2023 - Present |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-CURRICULUM, Member | 2023 - Present |
| Membership Committee, Center for Immunology and Microbial Research, Member | 2023 - Present |
| Microbiology and Immunology Graduate Studies Committee, Chair | 2022 - Present |
| Microbiology and Immunology Graduate Admissions Committee, Chair | 2022 - Present |
| Intellectual Property Committee, Member | 2019 - Present |
| Microbiology and Immunology Faculty Recruitment committee, Member | 2018 - 2019 |
| Microbiology and Immunology Seminar Committee, Member | 2017 - 2020 |
| Microbiology and Immunology Graduate Studies Committee, Member | 2017 - 2022 |
| Microbiology and Immunology Graduate Admissions Committee, Member | 2016 - 2022 |
| Microbiology and Immunology Qualifying exam committees, Member | 2015 - Present |
| New England Association of Schools and Colleges (NEASC) self-study panel, Site visit preparation | 2013 - 2013 |
| Liaison Committee on Medical Education (LCME) self study group, faculty representative | 2012 - 2012 |
| Department of Molecular Genetics and Microbiology Bacterial Pathogenesis Faculty Search Committee (UMass), Member | 2009 - 2011 |
| Library and Learning Resources Committee (UMass), Member | 2005 - 2012 |
| Extramural Seminar Series - UMass, Chair | 2004 - 2013 |
| Bacterial Pathogenesis Faculty Search Committee (UMich), Member | 2002 - 2003 |
| Microarray and Microchip Advisory Committee (UMich), Member | 2001 - 2002 |
| Departmental Promotions and Awards Committee (UMich), Member | 2001 - 2002 |
| Graduate admissions committee (UMich), Member | 2001 - 2002 |
Community Service
| Annual Graduate Program Overview for Master's students, Invited Speaker | 11/2023 - 11/2024 |
| Graduate Program Welcome Luncheon for SURE students, Introductory Speaker | 06/2023 - 06/2023 |
| Annual Program Directors’ “Graduate School Showcase” for neighboring schools, Bacteriology faculty overview presentation | 09/2018 - 09/2019 |
| NIH/SURE program, SURE preceptor | 05/2018 - 08/2018 |
| NIH/SURE program, preceptor | 05/2012 - 08/2012 |
Other Service
| NIH Lung Cellular, Molecular, and Immunobiology Study Section | 05/2024 - 06/2024 |
| European Science Foundation | 06/2023 - 06/2023 |
| NIH Lung Cellular, Molecular, and Immunobiology Study Section | 05/2023 - 06/2023 |
| Convener, Convener, ASM South-Central Branch Annual Meeting Symposium entitled, “Pathogenesis and Host Response”. | 11/2018 - 11/2018 |
| NIH Lung Cellular, Molecular, and Immunobiology Study Section, Reviewer, Grant Proposal | 05/2017 - 06/2017 |
| Infection and Immunity, Editorial Review Board Member | 2017 - Present |
| Frontiers in Cellular and Infection Microbiology, Associate Editor | 11/2015 - Present |
| NIH Host Interaction with Bacterial Pathogens (HIBP) study section | 10/2015 - 10/2015 |
| NIH Host Interaction with Bacterial Pathogens (HIBP) study section, Reviewer, Grant Proposal | 02/2015 - 02/2015 |
| GENETICS Journal, Ad Hoc Reviewer | 05/2014 - Present |
| Journal of Bacteriology | 2013 - 12/2019 |
| Frontiers in Cellular and Infection Microbiology, Editorial Review Board Member | 2010 - 11/2015 |
Teaching Experience
| SOM 621, Medicine, Course, Lecturer, Respiratory System | Fall 2024-2025 |
| SOM 610, Medicine, Course, Lecturer, Fundamentals of Biomedical Science | Fall 2024-2025 |
| MICRO 611, Medicine, Course, Lecturer, Medical Microbiology and Immunology | Fall 2023-2024 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology and Immunology | Fall 2023-2024 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2023-2024 |
| DENT 641, Dentistry, Course, Lecturer, Dental Microbiology and Immunology | Fall 2023-2024 |
| DENT 641, Dentistry, Lab, Facilitator, Dental Microbiology and Immunology | Fall 2023-2024 |
| SOM 610, Medicine, Course, Lecturer, Fundamentals of Biomedical Science | Fall 2023-2024 |
| MICRO 741, Graduate, Course, Lecturer, Graduate Fundamentals of Microbiology | Spring 2023-2024 |
| MICRO 750, Graduate, Course, Course Director, Proposal in Microbiology and Immunology | Spring 2023-2024 |
| MICRO 750, Graduate, Course, Course Director, Proposal in Microbiology and Immunology | Spring 2022-2023 |
| MICRO 725, Graduate, Course, Lecturer, Bacterial Structure and Function | Spring 2022-2023 |
| DENT 641, Dentistry, Course, Lecturer, Dental Microbiology and Immunology | Fall 2022-2023 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology and Immunology | Fall 2022-2023 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2022-2023 |
| MICRO 611, Medicine, Course, Lecturer, Medical Microbiology and Immunology | Fall 2022-2023 |
| MICRO 741, Graduate, Course, Lecturer, Graduate Fundamentals in Microbiology and Immunology | Spring 2022-2023 |
| M611, Medicine, Course, Lecturer, Medical Microbiology and Immunology | Fall 2021-2022 |
| DENT641, Dentistry, Course, Lecturer, Dental Microbiology and Immunology | Fall 2021-2022 |
| M611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2021-2022 |
| M611, Medicine, Lab, Facilitator, Medical Microbiology and Immunology | Fall 2021-2022 |
| M741, Graduate, Course, Lecturer, Graduate Fundamentals of Microbiology | Spring 2021-2022 |
| M750, Graduate, Course, Course Director, Proposal in Microbiology and Immunology | Fall 2021-2022 |
| MICRO 611, Medicine, Course, Lecturer, Medical Microbiology and Immunology | Fall 2020-2021 |
| DENT641, Dentistry, Course, Lecturer, Dental Microbiology and Immunology | Fall 2020-2021 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2020-2021 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology and Immunology | Fall 2020-2021 |
| M725, Graduate, Course, Lecturer, Bacterial Structure and Function | Spring 2020-2021 |
| MICRO 741, Graduate, Course, Lecturer, Graduate Fundamentals of Microbiology and Immunology | Spring 2020-2021 |
| MICRO 703, Graduate, Course, Course Director, Seminar in Microbiology and Immunology | Spring 2020-2021 |
| MICRO 611, Medicine, Course, Lecturer, Medical Microbiology and Immunology | Fall 2019-2020 |
| MICRO 703, Graduate, Course, Course Director, Seminar in Microbiology and Immunology | Spring 2019-2020 |
| MICRO 725, Graduate, Course, Lecturer, Bacterial Structure and Function | Spring 2019-2020 |
| DENT641, Dentistry, Lecture, Lecturer, Dental Microbiology and Immunology | Spring 2019-2020 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology and Immunology | Fall 2019-2020 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2019-2020 |
| DENT641, Dentistry, Lecture, Lecturer, Dental Microbiology and Immunology | Fall 2019-2020 |
| MICRO 741, Graduate, Course, Lecturer, Graduate Fundamentals in Microbiology | Spring 2019-2020 |
| MICRO 611, Medicine, Course, Lecturer, Medical Microbiology and Immunology | Fall 2018-2019 |
| MICRO 703, Graduate, Course, Course Director, Seminar in Microbiology | Spring 2018-2019 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology and Immunology | Fall 2018-2019 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2018-2019 |
| MICRO 741, Graduate, Course, Lecturer, Graduate Fundamentals in Microbiology | Spring 2018-2019 |
| MICRO 703, Graduate, Course, Course Director, Seminar in Microbiology and Immunology | Spring 2017-2018 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology and Immunology | Fall 2017-2018 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2017-2018 |
| MICRO 725, Graduate, Course, Lecturer, Bacterial Structure and Function | Spring 2017-2018 |
| ID 713, Graduate, Course, Lecturer, Bioinformatics and Genomics | Spring 2017-2018 |
| MICRO 611, Medicine, Lecture, Lecturer, Medical Microbiology and Immunology | Fall 2017-2018 |
| MICRO 741, Graduate, Course, Lecturer, Graduate Fundamentals of Microbiology | Spring 2017-2018 |
| 611, Medicine, Course, Lecturer, Medical Microbiology and Immunology | Fall 2016-2017 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology and Immunology | Fall 2016-2017 |
| 611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2016-2017 |
| 611, Medicine, Course, Exam Proctor, Medical Microbiology and Immunology | Fall 2016-2017 |
| MICRO 741, Graduate, Course, Lecturer, Graduate Fundamentals of Microbiology | Spring 2016-2017 |
| MICRO 611, Medicine, Course, Lecturer, Medical Microbiology and Immunology | Fall 2015-2016 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology and Immunology | Fall 2015-2016 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2015-2016 |
| MICRO 725, Graduate, Course, Lecturer, Bacterial Structure and Function | Spring 2015-2016 |
| MICRO 611, Medicine, Course, Lecturer, Medical Microbiology and Immunology | Fall 2014 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology and Immunology | Fall 2014 |
| MICRO 611, Medicine, Lecture, Lecturer, Medical Microbiology and Immunology | Fall 2013 |
Directed Student Learning
| Supervised Research, Advised: Azia McKenzie | 2024 - 2024 |
| Research Advisor, Advised: Cameron Huhn | 2023 - Present |
| Dissertation Committee Member, Insights into Toll-like Receptor (TLR) Signaling in Channel Catfish Advised: Kristianna Felch | 2021 - 2024 |
| Supervised Research, Advised: Anna Scasny | 2020 - 2020 |
| Supervised Research, Advised: Christian Yu | 2020 - 2020 |
| Doctoral Advisory Committee Member, Advised: Iftekhar Rafiqullah | 2020 - Present |
| Supervised Research, Advised: Kristianna Saelens | 2019 - 2019 |
| Preceptor, Advised: Charles Davis | 2018 - 2018 |
| Supervised Research, Advised: Jonathan Crider | 2017 - 2017 |
| Dissertation Committee Member, Insights into the Dynamics of Memory, Effector, and Apoptotic Cytotoxic T Lymphocytes in Channel Catfish, Ictalurus punctatus Advised: David Spencer | 2017 - 2018 |
| Dissertation Committee Member, Virulence Determinants of Nonencapsulated Streptococcus pneumoniae and the Consequences of Intra-Species Genetic Exchange Advised: Haley Pipkins | 2017 - 2018 |
| Dissertation Committee Member, Mechanisms Enhancing Persistence and Virulence of Streptococcus pneumoniae: Impact on Mucosal Infections and Invasive Potential Advised: Jessica Bradshaw | 2017 - 2018 |
| Dissertation Committee Member, Metabolic and Genetic Factors Impacting Intraocular Growth of Streptococcus pneumoniae Advised: Angela Benton | 2016 - 2019 |
| Research Advisor, Sialic Acid-Mediated Mechanisms of Complement Evasion in Nontypeable Haemophilus influenzae Advised: Mary Darby Jackson | 2016 - 2020 |
| Supervised Research, Advised: Hasan Mohammad | 2014 - 2014 |
| Supervised Research, Advised: David Spencer | 2014 - 2014 |
| Supervised Research, Advised: Jessica Bradshaw | 2014 - 2014 |
| Dissertation Committee Member, Advised: Srinjoy Chakraborty | 2012 - 2016 |
| Preceptor, Advised: Sandra Smart | 2012 - 2012 |
| Doctoral Advisory Committee Member, Advised: Srinjoy Chakraborti | 2012 - 2017 |
| Master's Thesis Committee Member, Advised: Michelle Harris | 2012 - 2013 |
| Preceptor, Advised: Juan Ramirez | 2011 - 2011 |
| Dissertation Committee Member, Advised: D.E. Cameron | 2010 - 2010 |
| Doctoral Advisory Committee Member, Advised: Bingling Xu | 2009 - 2012 |
| Dissertation Committee Chair, Advised: Emily Mallick | 2009 - 2012 |
| Dissertation Defense Committee Member, Advised: Francisca Cerda | 2008 - 2008 |
| Directed Individual/Independent Study, Advised: Cindy Lai | 2008 - 2008 |
| Preceptor, Advised: Christopher Doyle | 2007 - 2007 |
| Research Advisor, Roles of Secreted Virulence Factors in Pathogenicity of Haemophilus influenzae Advised: Charles Rosadini | 2006 - 2011 |
| Doctoral Advisory Committee Member, Advised: Vivian Banoit | 2005 - 2010 |
| Doctoral Advisory Committee Member, Advised: Joshua Fisher | 2004 - 2007 |
| Doctoral Advisory Committee Member, Advised: Kimberly Trimble | 2004 - 2005 |
| Dissertation Committee Member, Advised: Yi-Lin Yang | 2004 - 2009 |
| Dissertation Committee Member, Advised: Yi-Lin Yang | 2004 - 2004 |
| Doctoral Advisory Committee Member, Advised: Brian Skehan | 2004 - 2006 |
| Dissertation Committee Member, Advised: Robin Marty-Roix | 2004 - 2010 |
| Dissertation Committee Chair, Advised: Nang Muang | 2004 - 2011 |
| Research Advisor, Regulation of Reactive Nitrogen Species (RNS) Metabolism and Resistance Mechanisms in Haemophilus influenzae Advised: Jane Harrington | 2003 - 2008 |
| Dissertation Defense Committee Member, Advised: Aaron Fiorved | 2003 - 2003 |
| Dissertation Defense Committee Member, Advised: Rudi Fratti | 2003 - 2003 |
| Dissertation Defense Committee Member, Advised: Lisa Tatterson | 2002 - 2002 |
| Research Advisor, Advised: Ryan Tyler | 2001 - 2003 |
Fellows supervised
| Microbiology and Immunology (UMMC), Post-Doc Advisor, 1 fellows supervised | 05/2017 - 02/2019 |
| Microbiology and Molecular Genetics (UMASS), Post-Doc Advisor, 1 fellows supervised | 08/2004 - 02/2012 |
| Microbiology and Molecular Genetics (UMASS), Post-Doc Advisor, 1 fellows supervised | 11/2003 - 01/2005 |
| Microbiology and Immunology (UMICH), Post-Doc Advisor, 1 fellows supervised | 08/2001 - 09/2002 |