Wu Zhou

Wu Zhou

Professor

Department:
SOM-Otolaryngology - Head and Neck Surgery

Email:
wzhou@umc.edu

Work Phone:
(601) 815-4735

Education

University of Science and Technology of China, Hefei, Anhui, P. R. China, BS, Biophysics1990
School of Medicine and Dentistry, University of Rochester, PhD, Neuroscience

Current Positions

Professor, School of Medicine, Department of Otolaryngology And Communicative Science07/2006 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Sponsored Program Funding

Extramural, Multiplicative Computation in Vestibulo-Ocular Reflex (VOR), National Institutes of Health05/2007 - 04/2012
Extramural, Neuronal Mechanisms of Opioid Action, NIDA(Co-PI)04/2003 - 03/2005
Extramural, Motor Learning and Neural Plasticity in Vestibular System, National Institutes of Health10/2002 - 09/2008
Intramural, Neural Mechanisms of Opioid Action, UMC Intramural Support Programs(Co-PI)07/2002 - 06/2003
Extramural, Signal Processing in Central Otolith Pathways, NSBRI/NASA (Subcontract)06/2002 - 08/2003
Extramural, The Oculomotor System: Neural Structure and Function, NIH (Subcontract)06/2002 - 08/2003
Extramural, Otolith function on Cardiovascular System, American Hearing Research Foundation01/2002 - 12/2002
Intramural, Neural Mechanisms of Otolith Function on Cardiovascular System, UMC Intramural Research Support Program07/2001 - 07/2002
Extramural, Oculomotor System-Neural Structure and Function, NIH R01 EY04045(Co-PI)12/2000 - 11/2004
Extramural, Context-Specificity and Other Approaches to Neurovestibular Adaptation, NSBRI/NASA12/2000 - 01/2004
Intramural, Motor Learning and Neural Plasticity in Vestibular System, UMC Intramural Research Support Programs07/2000 - 06/2001
Extramural, Signal Processing and Adaptation in Central Otolith Pathways, NIH Program for the Support of Vestibular Research(Co-PI)09/1999 - 08/2003

Publications

Journal Article

Jeffcoat B, Shelukin A, Fong A, Mustain W, Zhou W. Alexander’s Law Revisited Journal of Neurophysiology. 2008; 100(1):154-1592008
Zhou W, Xu Y, Simpson I, Cai YD. Multiplicative computation in the vestibulo-ocular reflex (VOR) Journal of Neurophysiology. 2007; 97:2780-27892007
Mao L, Zhou B, Zhou W, Han S. Neural correlates of covert orienting of visual spatial attention along vertical and horizontal dimensions Brain Research. 2007; 1136:142-1532007
Zhu H, Jordan JR, Hardy S, Fulcher B, Childress C, Varner C, Windham B, Jeffcoat B, Rockhold RW, Zhou W. Linear acceleration-evoked cardiovascular responses in awake rats Journal of Applied Physiology. 2007;103(2):646-6542007
Zhou W, Tang BF, Newlands SD, King WM. Responses of monkey vestibular-only neurons to translation and angular rotation Journal of Neurophysiology. 2006;96: 2915-29302006
Zhou W, Simpson I, Xu Y, Fong A. Activity-dependent modulation: a non-linearity in the unilateral vestibulo-ocular reflex (VOR) pathways Experimental Brain Research. 2005;163: 267–2722005
Zhu H, Zhou W. Excitatory amino acid receptors are involved in the morphine-induced synchronous oscillatory discharges in the locus coeruleus European Journal of Pharmacology. 2005; 528(1-3):73-782005
Zhu H, Zhou W, X Li, T Ma, Ho IK, Rockhold RW. Methyl parathion increases neuronal activities in the rat locus coeruleus J. Biomed. Sci. 2004;11:732-7382004
Zhou W, Mustain W, Simpson I. Sound-evoked vestibulo-ocular reflexes (VOR) in trained monkeys Experimental Brain Research. 2004;156:129-1342004
Zhu H, Zhou W. Morphine induced long-term potentiation in the dentate gyrus of the hippocampus involves norepinephrine European Journal of Pharmacology. 2003;467:141-1442003
Zhou W, Weldon P, Tang BF, King WM. Rapid motor learning in the translational vestibulo-ocular reflex Journal of Neuroscience. 2003; 23(10):4288-42982003
Zhou W, King WM. Attentional sensitivity and asymmetries of vertical saccade generation in monkey Vision Research. 2002; 42:771-7792002
Zhu H, Zhou W. Morphine induces synchronous oscillatory discharges in the rat locus coeruleus Journal of Neuroscience. 2001; 21(21):RC1792001
Zhou W, Tang BF, King WM. Responses of rostral fastigial neurons to linear acceleration in an alert monkey Experimental Brain Research. 2001;139(1):111-1152001
King WM, Zhou W. New ideas about binocular coordination of eye movements: is there a chameleon in the primate family tree? New Anatomist Review. 2000; 261(4):153-1612000
Zhou W, King WM. Monocular and binocular mechanisms of saccade generation Brain and Behavioral Sciences. 1999; 22(4):704-7051999
Zhou W, King WM. Premotor commands encode monocular eye movements Nature. 1998; 393:692-6961998
Zhou W, King WM. Binocular eye movement not coordinated during REM sleep Experimental Brain Research. 1997;117:153-1601997
Chen L, Zhou W. Holes in illusory conjunction Psychonomic Bulletin & Review. 1997;4:507-5111997
King WM, Zhou W. Initiation of disjunctive smooth pursuit in monkeys: evidence that Hering’s Law of Equal Innervation is not obeyed by the smooth pursuit system Vision Research. 1995;35:3389-34001995
King WM, Zhou W, Tomlinson RD, McConville KMV, Page WK, Paige GD, Maxwell JS. Eye position signals in the abducens and oculomotor nuclei of monkeys during ocular convergence Journal of Vestibular Research. 1994;4:401-4081994
Xu Y, Simpson I, Tang X, Zhou W. Acoustic clicks activate both the canal and otolith vestibulo-ocular reflex pathways in behaving monkeys J Assoc Res Otolaryngol. 2009;10(4):569-77
Zhu H, Tang Z, Wei W, Xu Y, Mustain W and Zhou W. Clicked-evoked responses in vestibular afferents in rats J. Neurophysiol. 106(2):754-763, 2011
Zhu H and Zhou W. Discharge activities of neurons in the nucleus paragigantocellularis during the development of morphine tolerance and dependence: a single unit study in chronically implanted rats Eur J Pharmacol. 2010;636(1-3):65-72
Lewis A, Mustain W, Xu Y, Eby T, Zhou W. Frequency tuning in the tone burst-evoked myogenic potentials in extraocular muscles in normal human subjects J Otolaryngol Head Neck Surg. 2010;39(5):491-497
Tang X, Xu Y, Simpson I, Jeffcoat B, Mustain W, Zhou W. The conjugacy of the vestibulo-ocular reflex evoked by single labyrinth stimulation in awake monkeys Exp Brain Res. 2010;206(3):249-55

Book Chapter

King WM, Zhou W. Neural basis for disjunctive eye movements. Ann. N.Y. Acad. Sci. Neurobiology of Eye Movement: From Molecules to Behavior 20022002
Zhou W, Weldon P, Tang BF, King WM. Rapid adaptation of translational vestibulo-ocular reflex: Independence of retinal slip; Ann. N.Y. Acad. Sci. Neurobiology of Eye Movement: From Molecules to Behavior Wiley InterScience, 20022002
Zhou W, Weldon P, Tang BF, King WM. Rapid adaptation of translational vestibulo-ocular reflex: time course, consolidation and specificity. Ann. N.Y. Acad. Sci. Neurobiology of Eye Movement: From Molecules to Behavior Wiley InterScience, 20022002
King WM, Zhou W, Tomlinson RD, McConville KMV, Page WK, Paige GD, Maxwell JS. Eye position signals in the abducens and oculomotor nuclei of monkeys during ocular convergence. Contemporary Ocular Motor and Vestibular Research: A Tribute to David A. Robinson Thieme Medical Publishers, New York, 19931993
Zhou W, King WM. Ocular selectivity in oculomotor pathways. New Directions in Vestibular Research, Ann. N.Y. Acad. Sci, 1996

Presentations

Abstract, Click-evoked responses in vestibular afferents in rats, Society for Neuroscience Annual Meeting, Chicago, IL10/2009
Abstract, Vestibular sound-evoked myogenic potentials (VEMP) recorded from trapezius and extraocular muscles in an awake monkey, Society for Neuroscience Annual Meeting, Chicago, IL10/2009
Abstract, Frequency tuning of bone conducted tone burst-evoked myogenic potential in extraocular muscles (BOVEMP) in normal human subjects, The Triological Society Annual Meeting05/2009
Abstract, Re-Examination of VEMP Frequency Tuning in Normal Subjects, American Academy of Audiology Annual Meeting, Charlotte, NC04/2008
Abstract, Re-examination of the effect of tonic EMG level on the tone-evoked vestibular myogenic responses in the sternocleidomastoid muscles (SCM) in normal human subjects, XXV Barany Society Meeting2008
Abstract, Extra-ocular myogenic potentials (OVEMP) evoked by acoustic tone pips with different frequencies, The Triological Society Annual Meeting2008
Abstract, Non-linear interaction of vestibular and eye position signals in the vestibular nuclei, Society for Neuroscience Annual Meeting, San Diego, CA11/2007
Abstract, Nonlinear interaction of vestibular and eye position signals in the abducens neurons, Society for Neuroscience Annual Meeting, Atlanta, GA10/2006
National and International Invited Seminars/Lectures, Multiplicative computation in the vestibulo-ocular reflex (VOR), Johns Hopkins University, Hear and Balance Lecture Series, Baltimore, MD08/2006
National and International Invited Seminars/Lectures, Multiplicative computation in the vestibulo-ocular reflex (VOR), University of Michigan, Hearing, Balance and Chemical Senses Lecture Series, Ann Arbor, MI05/2006
Abstract, Effect of aging on the otolith-driven cardiovascular responses in rat, Association of Research in Otolaryngology2006
Abstract, Acoustic click evokes short-latency excitatory responses in the ipsilateral abducens neurons in behaving monkeys, Neural Control of Movement Annual Meeting2005
Abstract, Alexander’s Law Revisited, Association of Research in Otolaryngology2005
Abstract, Effects of morphine on norepinephrine release in rat hippocampus: an in vivo voltammetry study, Society for Neuroscience Annual Meeting2005
Abstract, Multiplicative computation in the vestibulo-ocular reflex (VOR), Society for Neuroscience Annual Meeting2005
Abstract, Bilateral labyrinthectomy reduces linear acceleration-evoked cardiovascular responses in awake rats, Association of Research in Otolaryngology2004
Abstract, Characteristics of sound-evoked vestibulo-ocular reflexes in awake and trained monkeys, Association of Research in Otolaryngology2004
Abstract, Coding of intention to shift fixation in frontal pursuit area (FPA), Society for Neuroscience Annual Meeting2004
Abstract, Expression of VOR motor learning following translabyrinthine electrical stimulation in monkeys, Society for Neuroscience Annual Meeting2003
Abstract, Eye movements evoked by electrical stimulation to labyrinth in monkeys, Neural Control of Movement Annual Meeting2003
Abstract, Mechanisms underlying the morphine-induced synchronous oscillatory discharges in the locus coeruleus, Society for Neuroscience Annual Meeting2003
Abstract, Shared gain control for multiple eye movements, Society for Neuroscience Annual Meeting2003
Abstract, Sound-evoked vestibulo-ocular reflexes are modulated by gaze eccentricity and vergence angle, Neural Control of Movement Annual Meeting2003
Abstract, Tone-evoked eye movements are modulated by tone frequency, Neural Control of Movement Annual Meeting2003
Abstract, Translational vestibulo-ocular reflex (TVOR) signal processing by monkey vestibular neurons, Society for Neuroscience Annual Meeting2003
Abstract, Cerebellar lesions impair rapid vestibulo-ocular reflex (VOR) motor learning in monkey, Society for Neuroscience Annual Meeting2002
Abstract, Effects of methyl parathion on the firing pattern of the rat locus coeruleus, FASEB2002
Abstract, Hebbian learning in the rapid adaptation of the translational vestibulo-ocular reflex, Society for Neuroscience Annual Meeting2002
Invited Symposia, Learning by purposefully doing. Vestibular influences on eye movements., Satellite Meeting to Barany Society Meeting2002
Abstract, Morphine-induced potentiation in the hippocampus involves norepinephrine, Society for Neuroscience Annual Meeting2002
Abstract, Otolith function on cardiovascular system, Society of Barany Meeting2002
Abstract, The medial and inferior vestibular nuclei mediate otolith-cardiovascular reflex in rats, Society for Neuroscience Annual Meeting2002
National and International Invited Seminars/Lectures, Rapid Motor Learning in the Linear Vestibulo-Ocular Reflex (LVOR), Johns Hopkins University, Hearing and Balance Lecture Series, Baltimore, MD02/2001
Abstract, Initiation of the linear vestibulo-ocular reflex (LVOR), Neural Control of Movement Annual Meeting2001
Abstract, Morphine induces synchronous oscillatory discharges in the locus coeruleus, Society for Neuroscience Annual Meeting2001
Abstract, Retinal Slip Not Required for Rapid Adaptation of the Translational Vestibulo-Ocular Reflex, Society for Neuroscience Annual Meeting2001
Invited Symposia, Do vestibular neurons discriminate translation from tilt?, Neural Control of Movement2000
Invited Symposia, New concepts of final common pathways, Investigative Ophthalmology & Visual Science Annual Meeting2000
Abstract, Responses of eye movement related vestibular neurons to linear acceleration, Society for Neuroscience Annual Meeting2000
Abstract, Vestibular neurons encode linear translation and head tilt with respect to gravity, Society for Neuroscience Annual Meeting2000
Abstract, Initial eye speed during vestibulo-ocular reflexes (VOR) is modulated by prior experience, Neural Control of Movement Annual Meeting1999
Poster Presentation, Rapid motor learning in vestibulo-ocular reflex guided by context cues, Society for Neuroscience, 1999;25:6611999
Poster Presentation, Characteristics of angular and linear motion signals in the macaque vestibular nuclei, Society for Neuroscience, 1998;24:17441998
Poster Presentation, Initiation of macaque linear vestibular ocular reflex (LVOR): dependence on target location and non-visual cues, Society for Neuroscience, 1998;24:16581998
Invited Symposia, New Concepts of Strabismus: Neurophysiology of binocular coordination of horizontal eye movements., Investigative Ophthalmology & Visual Science Annual Meeting1998
Poster Presentation, An ocular selectivity model of eye movement control: implications for strabismus, Society for Neuroscience, 1997;23:8931997
Invited Symposia, Binocular coordination of eye movements, Society for Neuroscience Annual Meeting1997
Poster Presentation, Monocular rather than conjugate saccade burst generators in paramedian pontine reticular formation (PPRF), Society for Neuroscience, 1997;23:10221997
Abstract, Binocular coordination during REM sleep, 10th APSS Annual Meeting1996
Poster Presentation, Ocular selectivity of bursts in horizontal burst-tonic units during disjunctive saccades, Society for Neuroscience, 1996;22:20221996
Poster Presentation, Binocular coordination of eye movements during wakefulness, non-REM and REM sleep in monkeys, Society for Neuroscience, 1995;21:9221995
Poster Presentation, Encoding of eye movement parameters by burst-tonic neurons during disjunctive smooth pursuit and saccades, Society for Neuroscience, 1995;21:6931995
Abstract, Encoding of monocular eye movement signals by burst-tonic units during disjunctive saccades and smooth pursuit. New Directions in Vestibular Research, The New York Academy of Sciences1995
Abstract, Do monkeys use retinal slips from each eye to initiate disjunctive smooth pursuit movements?, Binocular Oculomotor Coordination & Plasticity: Implications for Strabismus, Santorini10/1994
Poster Presentation, Modulation of motion aftereffect (MAE) by engagement of attention in an auditory task, Investigative Ophthalmology & Visual Science, 1994;35:18381994
Poster Presentation, Visual surface perception of untextured cross stereogram determined by fixation point in depth in near viewing conditions, Society for Neuroscience, 1994;20:16661994
Poster Presentation, Eye position signals in the abducens nucleus of monkeys during ocular convergence, Society for Neuroscience, 1993;19:6881993
Abstract, Shape transformation in illusory conjunction, Investigative Ophthalmology & Visual Science, 1993;34:10821993
Poster Presentation, Topological perception: holes in illusory conjunction and visual search, Investigative Ophthalmology & Visual Science, 1992;33:9581992

Professional Membership and Service

Journal of Vision, Reviewer, Journal Article2008
Journal of Neuroscience, Reviewer, Journal Article2007
Neuroscience Research, Reviewer, Journal Article2007
The IEEE Transactions on Biomedical Engineering, Reviewer, Journal Article2005 - 2006
Association of Research in Otolaryngology, Member2003 - Present
New York Academy of Sciences, Member2002 - Present
Journal of Neurophysiology, Reviewer, Journal Article2002 - 2009
Neural Control of Movement, Member1996 - Present
Society for Neuroscience, Member1993 - Present
Experimental Brain Research, Reviewer, Journal Article2007
Reviewer, Ad Hoc Reviewer, NIH Study Section IFCN-22007
Neuroscience, Reviewer, Journal Article2006
Experimental Brain Research, Reviewer, Journal Article2004
Journal of Applied Physiology, Reviewer, Journal Article2004
Journal of Motor Disorders, Reviewer, Journal Article2004
Vision Research, Reviewer, Journal Article2004
Brain Research, Reviewer, Journal Article2002
Journal of Experimental Biology, Reviewer, Journal Article2001
Investigative Ophthalmology & Visual Science, Reviewer, Journal Article2000
Netherlands Organization for Scientific Research, Reviewer, Journal Article1999