Heng Zeng, MD
Associate Professor
Department:
SOM-Pharmacology/Toxicology
Email:
hzeng@umc.edu
Work Phone:
(601) 984-1611
Biography
Dr. Zeng received an M.D degree in medical school from the University of South China in 1987. After that time, Dr. Zeng worked as a Surgeon at the Department of Surgery of Hengyang Medical First Hospital for ten years. In 1997, she came to the U.S.A. to study postdoctoral training at Southern Illinois University School of Medicine. In 1999-2011, she worked at Vanderbilt University Medical Center. She joined the University of Mississippi Medical Center in 2011. She has been an assistant professor at the Department of Pharmacology and Toxicology since 2020.
Her research interest focuses on elucidating the novel roles of the mitochondrial frataxin-Sirtuin 3-TIGAR signaling pathway and mitochondrial ferroptosis/iron-sulfur cluster that regulate vascular endothelial metabolisms, mitochondrial dysfunction, and heart failure of diabetic cardiomyopathy, cardiomyopathy of Friedreich’s Ataxia by using endothelial-specific knockout, cardiomyocyte-specific knockout mouse models. She is also interested in gender differences in pressure-induced coronary autoregulation in heart failure, and exploring cardiac adaptation disorders during pregnancy in rats with preeclampsia. She has published a total of 62 papers in peer-reviewed journals (including 7 Senior Authors, 4 Co-Senior Authors, 11 First Authors, and 1 Co-First Author)
Education
| University of South China, MD, Medicine | 1987 |
| University of Southern Illinois, USA , School of Medicine, postdoctoral, Pharmacology |
Current Positions
| Associate Professor, School of Medicine, Department of Pharmacology / Toxicology | 07/2026 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, UMMC, School of Medicine | 07/2020 - 06/2026 |
| Scientist, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 09/2011 - 06/2020 |
| Scientist, Vanderbilt University, School of Medicine, Department of Pediatrics | 07/2005 - 08/2011 |
| Research Associate, Vanderbilt University, School of Medicine, Department of Medicine | 10/1999 - 06/2005 |
| Postdoctoral fellow, South Illinois University, School of Medicine, Department of Pharmacology / Toxicology | 10/1997 - 09/1999 |
| Assistant Professor, University of South China, School of Medicine, Department of Surgery | 07/1987 - 09/1997 |
Sponsored Program Funding
| Extramural, Exploring TIGAR in cardiomyopathy of Friedreich's ataxia, NHLBI RO1 | 09/2027 - 08/2031 |
| Extramural, Mitochondrial Regulation of Coronary Function in Friedreich Ataxia, NHLBI RO1 | 09/2027 - 08/2031 |
| Extramural, Endothelial TIGAR-Frataxin Signaling in Diabetic Coronary Microvascular Dysfunction, NHLBI RO1 | 09/2027 - 08/2031 |
| Extramural, Endothelial PHD2 in the coronary autoregulation., NHLBI RO1 | 09/2027 - 08/2031 |
| Extramural, Beyond the Placenta: Coronary Endothelial Dysfunction in Maternal Cardiac and Fetal Adaptation Failure, NHLBI RO1 | 09/2027 - 08/2031 |
| Extramural, Immune and Vascular Mechanisms of Maternal Cardiac Dysfunction During Preeclampsia and Postpartum., NIH PPG | 07/2027 - 06/2032 |
| Extramural, Coronary Microvascular Dysfunction in Friedreich's Ataxia, NHLBI RO1 | 04/2027 - 03/2031 |
| Intramural, p53 acetylation in microvascular rarefaction and heart failure, UMMC | 11/2023 - 11/2025 |
| Extramural, p53 acetylation in microvascular rarefaction and heart failure, NHLBI | 09/2022 - 08/2024 |
| Extramural, Endothelial glucose metabolism and Coronary microvascular dysfunction in aged female, P20NIH/GM104357 pilot grant | 12/2021 - 04/2023 |
| Extramural, Endothelial PHD2 in hypertensive vascular remodeling, NHLBI | 09/2021 - 12/2025 |
| Extramural, Coronary microvascular rarefaction in diabetic/obese heart, NHLBI | 03/2017 - 02/2022 |
Publications
Preprint | |
| He X, Cantrell AC, Williams QA, Gu W, Chen Y, Chen JX, Zeng H, P53 Acetylation Exerts Critical Roles In Pressure Overload Induced Coronary Microvascular Dysfunction and Heart Failure. bioRxiv : the preprint server for biology, 2023 Feb 9; | 2023 |
Journal Article | |
| Bhattarai U, Niu Z, Pan L, He X, Wang D, Orman TC, Wang H, Zeng H, Chen JX, Xu X, Speed JS, Clemmer JS, Hall JE, Chen Y, Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac oxidative stress, inflammation, and heart failure development. Redox biology, 2026 Apr;91:104082 | 2026 |
| Bhattarai U, He X, Niu Z, Pan L, Wang D, Wang H, Zeng H, Chen JX, Speed JS, Clemmer JS, Chen Y, Pharmacological inhibition of IL12β is effective in treating pressure overload-induced cardiac inflammation and heart failure. Frontiers in immunology, 2025;16:1624940 | 2025 |
| Pan L, He X, Xu R, Bhattarai U, Wang D, Wang H, Niu Z, Zeng H, Clemmer JS, Speed JS, Chen JX, Chen Y, PHD2 Deletion in CD8(+) T Cells Worsens TAC-Induced Cardiac Inflammation, Heart Failure, and Pulmonary Remodeling. Hypertension (Dallas, Tex. : 1979), 2025 Nov;82(11):2040-2054 | 2025 |
| Bhattarai U, He X, Niu Z, Pan L, Wang D, Wang H, Zeng H, Chen JX, Speed JS, Clemmer JS, Hall JE, Chen Y, Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development. bioRxiv : the preprint server for biology, 2025 Sep 11; | 2025 |
| Cantrell AC, Williams QA, Chen JX, Zeng H, Mutation of p53 Acetylation Protects Against Angiotensin-II-Induced Cardiac Dysfunction and Fibrosis. International journal of molecular sciences, 2025 Oct 3;26(19) | 2025 |
| He X, Cantrell AC, Williams QA, Gu W, Chen Y, Chen JX, Zeng H, p53 Acetylation Exerts Critical Roles in Pressure Overload-Induced Coronary Microvascular Dysfunction and Heart Failure in Mice. Arteriosclerosis, thrombosis, and vascular biology, 2024 Apr;44(4):826-842 | 2024 |
| Cantrell AC, Zeng H, Chen JX, The Therapeutic Potential of Targeting Ferroptosis in the Treatment of Mitochondrial Cardiomyopathies and Heart Failure. Journal of cardiovascular pharmacology, 2024 Jan 1;83(1):23-32 | 2024 |
| He X, Williams QA, Cantrell AC, Besanson J, Zeng H, Chen JX, TIGAR Deficiency Blunts Angiotensin-II-Induced Cardiac Hypertrophy in Mice. International journal of molecular sciences, 2024 Feb 19;25(4) | 2024 |
| Pan L, He X, Xu R, Bhattarai U, Niu Z, do Carmo J, Sun Y, Zeng H, Clemmer JS, Chen JX, Chen Y, Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance. GeroScience, 2024 Aug;46(4):3945-3956 | 2024 |
| Cantrell AC, Besanson J, Williams Q, Hoang N, Edwards K, Bishop GR, Chen Y, Zeng H, Chen JX, Ferrostatin-1 specifically targets mitochondrial iron-sulfur clusters and aconitase to improve cardiac function in Sirtuin 3 cardiomyocyte knockout mice. Journal of molecular and cellular cardiology, 2024 Jul;192:36-47 | 2024 |
| Liu B, Zeng H, Su H, Williams QA, Besanson J, Chen Y, Chen JX, Endothelial Cell-Specific Prolyl Hydroxylase-2 Deficiency Augments Angiotensin II-Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice. Journal of the American Heart Association, 2024 Aug 20;13(16):e035769 | 2024 |
| Bhattarai U, Xu R, He X, Pan L, Niu Z, Wang D, Zeng H, Chen JX, Clemmer JS, Chen Y, High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure. Redox biology, 2024 Oct;76:103325 | 2024 |
| Chen JX, Zhang J, Chen Y, Zeng H, Knockout of Sirtuin 3 in endothelial cells impairs endothelial-dependent relaxation and myogenic response in mice. Physiological reports, 2024 Oct;12(20):e70060 | 2024 |
| Chen JX, Li L, Cantrell AC, Williams QA, Zeng H, High Glucose Activates Prolyl Hydroxylases and Disrupts HIF-α Signaling via the P53/TIGAR Pathway in Cardiomyocyte. Cells, 2023 Mar 31;12(7) | 2023 |
| Su H, Cantrell AC, Chen JX, Gu W, Zeng H, SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation. Cells, 2023 May 19;12(10) | 2023 |
| He X, Xu R, Pan L, Bhattarai U, Liu X, Zeng H, Chen JX, Hall ME, Chen Y, Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling. Frontiers in immunology, 2023;14:1215855 | 2023 |
| He X, Cantrell AC, Williams QA, Chen JX, Zeng H, TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury. Physiological reports, 2022 Apr;10(8):e15234 | 2022 |
| He X, Zeng H, Cantrell AC, Williams QA, Chen JX, Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure. Journal of cellular physiology, 2022 Aug;237(8):3317-3327 | 2022 |
| He X, Zeng H, Cantrell AC, Chen JX, Regulatory role of TIGAR on endothelial metabolism and angiogenesis. Journal of cellular physiology, 2021 Nov;236(11):7578-7590 | 2021 |
| Su H, Cantrell AC, Zeng H, Zhu SH, Chen JX, Emerging Role of Pericytes and Their Secretome in the Heart. Cells, 2021 Mar 4;10(3) | 2021 |
| Li L, Zeng H, He X, Chen JX, Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism. Journal of the American Heart Association, 2021 Feb;10(5):e018913 | 2021 |
| Zeng H, He X, Chen JX, A Sex-Specific Role of Endothelial Sirtuin 3 on Blood Pressure and Diastolic Dysfunction in Female Mice. International journal of molecular sciences, 2020 Dec 21;21(24) | 2020 |
| Feng X, Su H, He X, Chen JX, Zeng H, SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis. Cells, 2020 Nov 20;9(11) | 2020 |
| Su H, Zeng H, He X, Zhu SH, Chen JX, Histone Acetyltransferase p300 Inhibitor Improves Coronary Flow Reserve in SIRT3 (Sirtuin 3) Knockout Mice. Journal of the American Heart Association, 2020 Sep 15;9(18):e017176 | 2020 |
| Zhao Y, Zeng H, Liu B, He X, Chen JX, Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury. American journal of physiology. Renal physiology, 2020 Aug 1;319(2):F345-F357 | 2020 |
| Zeng H, He X, Chen JX, Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload-Induced Heart Failure. Journal of the American Heart Association, 2020 Jun 2;9(11):e015895 | 2020 |
| Su H, Zeng H, Liu B, Chen JX, Sirtuin 3 is essential for hypertension-induced cardiac fibrosis via mediating pericyte transition. Journal of cellular and molecular medicine, 2020 Jul;24(14):8057-8068 | 2020 |
| Zeng H, Chen JX, Sirtuin 3, Endothelial Metabolic Reprogramming, and Heart Failure With Preserved Ejection Fraction. Journal of cardiovascular pharmacology, 2019 Oct;74(4):315-323 | 2019 |
| Zeng H, Chen JX, Microvascular Rarefaction and Heart Failure With Preserved Ejection Fraction. Frontiers in cardiovascular medicine, 2019;6:15 | 2019 |
| He X, Zeng H, Chen JX, Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease. Journal of cellular physiology, 2019 Mar;234(3):2252-2265 | 2019 |
| He X, Zeng H, Roman RJ, Chen JX, Inhibition of prolyl hydroxylases alters cell metabolism and reverses pre-existing diastolic dysfunction in mice. International journal of cardiology, 2018 Dec 1;272:281-287 | 2018 |
| Zhou LY, Zeng H, Wang S, Chen JX, Regulatory Role of Endothelial PHD2 in the Hepatic Steatosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018;48(3):1003-1011 | 2018 |
| He X, Zeng H, Chen ST, Roman RJ, Aschner JL, Didion S, Chen JX, Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. Journal of molecular and cellular cardiology, 2017 Nov;112:104-113 | 2017 |
| Wang S, Zeng H, Chen ST, Zhou L, Xie XJ, He X, Tao YK, Tuo QH, Deng C, Liao DF, Chen JX, Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. Journal of cellular and molecular medicine, 2017 Sep;21(9):1967-1978 | 2017 |
| Tao YK, Zeng H, Zhang GQ, Chen ST, Xie XJ, He X, Wang S, Wen H, Chen JX, Notch3 deficiency impairs coronary microvascular maturation and reduces cardiac recovery after myocardial ischemia. International journal of cardiology, 2017 Jun 1;236:413-422 | 2017 |
| Wang S, Zeng H, Xie XJ, Tao YK, He X, Roman RJ, Aschner JL, Chen JX, Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. Oncotarget, 2016 Sep 13;7(37):58848-58861 | 2016 |
| He X, Zeng H, Chen JX, Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia. International journal of cardiology, 2016 Jul 15;215:349-57 | 2016 |
| Zeng H, He X, Tuo QH, Liao DF, Zhang GQ, Chen JX, LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. Scientific reports, 2016 Feb 12;6:20931 | 2016 |
| Hou X, Zeng H, Tuo QH, Liao DF, Chen JX, Apelin Gene Therapy Increases Autophagy via Activation of Sirtuin 3 in Diabetic Heart. Diabetes research (Fairfax, Va.), 2015 Oct;1(4):84-91 | 2015 |
| Zeng H, Vaka VR, He X, Booz GW, Chen JX, High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. Journal of cellular and molecular medicine, 2015 Aug;19(8):1847-56 | 2015 |
| Hou X, Zeng H, He X, Chen JX, Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes. Journal of cellular and molecular medicine, 2015 Jan;19(1):53-61 | 2015 |
| Zeng H, Chen JX, Conditional knockout of prolyl hydroxylase domain protein 2 attenuates high fat-diet-induced cardiac dysfunction in mice. PloS one, 2014;9(12):e115974 | 2014 |
| Zeng H, Li L, Chen JX, Loss of Sirt3 limits bone marrow cell-mediated angiogenesis and cardiac repair in post-myocardial infarction. PloS one, 2014;9(9):e107011 | 2014 |
| Zeng H, He X, Hou X, Li L, Chen JX, Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3. American journal of physiology. Heart and circulatory physiology, 2014 Feb 15;306(4):H585-97 | 2014 |
| Caito S, Zeng H, Aschner JL, Aschner M, Methylmercury alters the activities of Hsp90 client proteins, prostaglandin E synthase/p23 (PGES/23) and nNOS. PloS one, 2014;9(5):e98161 | 2014 |
| Li L, Zeng H, Hou X, He X, Chen JX, Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction. PloS one, 2013;8(9):e71041 | 2013 |
| Li L, Zeng H, Chen JX, Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction. American journal of physiology. Heart and circulatory physiology, 2012 Sep 1;303(5):H605-18 | 2012 |
| Zeng H, Li L, Chen JX, Overexpression of angiopoietin-1 increases CD133+/c-kit+ cells and reduces myocardial apoptosis in db/db mouse infarcted hearts. PloS one, 2012;7(4):e35905 | 2012 |
| Chen JX, Tuo Q, Liao DF, Zeng H, Inhibition of protein tyrosine phosphatase improves angiogenesis via enhancing Ang-1/Tie-2 signaling in diabetes. Experimental diabetes research, 2012;2012:836759 | 2012 |
| Chen JX, Zeng H, Reese J, Aschner JL, Meyrick B, Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model. American journal of physiology. Heart and circulatory physiology, 2012 Feb 15;302(4):H1003-12 | 2012 |
| Tuo QH, Xiong GZ, Zeng H, Yu HD, Sun SW, Ling HY, Zhu BY, Liao DF, Chen JX, Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition. Acta pharmacologica Sinica, 2011 Jan;32(1):45-51 | 2011 |
| Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B, Requirement of argininosuccinate lyase for systemic nitric oxide production. Nature medicine, 2011 Nov 13;17(12):1619-26 | 2011 |
| Vadivel A, Aschner JL, Rey-Parra GJ, Magarik J, Zeng H, Summar M, Eaton F, Thébaud B, L-citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats. Pediatric research, 2010 Dec;68(6):519-25 | 2010 |
| Fike CD, Pfister SL, Slaughter JC, Kaplowitz MR, Zhang Y, Zeng H, Frye NR, Aschner JL, Protein complex formation with heat shock protein 90 in chronic hypoxia-induced pulmonary hypertension in newborn piglets. American journal of physiology. Heart and circulatory physiology, 2010 Oct;299(4):H1190-204 | 2010 |
| Aschner JL, Zeng H, Kaplowitz MR, Zhang Y, Slaughter JC, Fike CD, Heat shock protein 90-eNOS interactions mature with postnatal age in the pulmonary circulation of the piglet. American journal of physiology. Lung cellular and molecular physiology, 2009 Mar;296(3):L555-64 | 2009 |
| Tuo QH, Zeng H, Stinnett A, Yu H, Aschner JL, Liao DF, Chen JX, Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis. American journal of physiology. Heart and circulatory physiology, 2008 Jun;294(6):H2547-57 | 2008 |
| Zeng H, Ornatowska M, Joo MS, Sadikot RT, TREM-1 expression in macrophages is regulated at transcriptional level by NF-kappaB and PU.1. European journal of immunology, 2007 Aug;37(8):2300-8 | 2007 |
| Aschner JL, Foster SL, Kaplowitz M, Zhang Y, Zeng H, Fike CD, Heat shock protein 90 modulates endothelial nitric oxide synthase activity and vascular reactivity in the newborn piglet pulmonary circulation. American journal of physiology. Lung cellular and molecular physiology, 2007 Jun;292(6):L1515-25 | 2007 |
| Chen JX, Zeng H, Tuo QH, Yu H, Meyrick B, Aschner JL, NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation. American journal of physiology. Heart and circulatory physiology, 2007 Apr;292(4):H1664-74 | 2007 |
| Sadikot RT, Zeng H, Azim AC, Joo M, Dey SK, Breyer RM, Peebles RS, Blackwell TS, Christman JW, Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. European journal of immunology, 2007 Apr;37(4):1001-9 | 2007 |
| Chen JX, Zeng H, Lawrence ML, Blackwell TS, Meyrick B, Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase. American journal of physiology. Heart and circulatory physiology, 2006 Oct;291(4):H1563-72 | 2006 |
| Sadikot RT, Zeng H, Joo M, Everhart MB, Sherrill TP, Li B, Cheng DS, Yull FE, Christman JW, Blackwell TS, Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. Journal of immunology (Baltimore, Md. : 1950), 2006 Apr 15;176(8):4923-30 | 2006 |
| Everhart MB, Han W, Parman KS, Polosukhin VV, Zeng H, Sadikot RT, Li B, Yull FE, Christman JW, Blackwell TS, Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation. Journal of leukocyte biology, 2005 Feb;77(2):173-80 | 2005 |
| Sadikot RT, Zeng H, Yull FE, Li B, Cheng DS, Kernodle DS, Jansen ED, Contag CH, Segal BH, Holland SM, Blackwell TS, Christman JW, p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. Journal of immunology (Baltimore, Md. : 1950), 2004 Feb 1;172(3):1801-8 | 2004 |
| Chen JX, Zeng H, Chen X, Su CY, Lai CC, Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage. Pharmacological research, 2001 Jan;43(1):63-9 | 2001 |
Presentations
| Poster Presentation, Loss of Endothelial Oxygen Sensing Causes Peripartum Cardiomyopathy and Fetal Growth Restriction: A Novel Role for PHD2 in the Cardiovascular‐Placental Axis, AHA hypertension meeting, Arlington, Virginia | 10/2026 |
| Poster Presentation, Sex Differences of Cardiac Mitochondrial Function in Endothelial PHD2 Deficient Mice, UMMC& AU NIH SCORE: 3rd Annual Workshop & Symposium, UMMC | 06/2026 |
| Regional Invited Seminars/Lectures, The emerging role of p53 acetylation in heart failure, Seminar of Department Pharmacology/Toxicology of UMMC, UMMC | 03/2026 |
| National and International Invited Seminars/Lectures, Endothelial PHD2 Deficiency Impairs Nitric Oxide Signaling and Cardiomyocyte Mitochondrial Ca²⁺ Uptake, Leading to Diastolic Dysfunction, The Academy Of Cardiovascular Research Excellence, Honolulu, Hawaii | 01/2026 |
| Poster Presentation, Genetic and pharmacological inhibition of IL-12β attenuates pressure overload-induced cardiac inflammation and heart failure, American Heart Association Scientific Sessions 2025, New Orleans, Louisiana | 11/2025 |
| Poster Presentation, Sex Differences of Cardiac Mitochondrial Function in Endothelial PHD2 Deficient Mice, 2025 Sex Differences and Women’s Health Research Conference, New Orleans | 10/2025 |
| Poster Presentation, Failure of Cardiac Adaptation to Pregnancy in a Superimposed Preeclampsia Model Potentially Leads to Placental Insufficiency and Fetal Growth Restriction, AHA Hypertension 2025, Baltimore, Maryland, USA | 09/2025 |
| Poster Presentation, Shifts in Energy Metabolism Potentially Lead to Cardiac Dysfunction in PHD2ECKO Male Mice, American Society for Pharmacology and Experimental Therapeutics (ASPET), Portland, Oregon, USA | 04/2025 |
| Regional Invited Seminars/Lectures, Emerging role of endothelial SIRT3 on the vascular function, Department of Pharmacology and Toxicology, UMMC | 03/2025 |
| Platform Presentations, Endothelial Phd2 Deficiency Impairs Endothelial-Dependent Relaxation And Promotes Coronary, International Vascular Biology Meeting - IVBM, Amsterdam, Netherlands | 07/2024 |
| State/Local Invited Seminars/Lectures, P53 acetylation in cardiac fibrosis microvascular dysfunction, and heart failure in mice, Department of Pharmacology, Department of Pharmacology, UMMC | 02/2024 |
| Poster Presentation, Deficiency Of Sirtuin 3 In Endothelium Reduces Endothelial-Dependent Relaxation And Impairs Myogenic Response In Coronary And Middle Cerebral Arteries Of Mice., AHA, Philadelphia. PA | 11/2023 |
| Poster Presentation, Endothelial Phd2 Deficiency Promotes Angiotensin-Ii-Induced Arterial Stiffness And Coronary Microvascular Dysfunction., NAVB, Newport, Ri | 10/2023 |
| Poster Presentation, Treatment with PFKFB3 inhibitor potentially improves diastolic function and arterial stiffness in PHD2ECKO mice., APS Physiology, Long Beach, LA | 04/2023 |
| State/Local Invited Seminars/Lectures, Sex differences of endothelial Sirt3 in Angiotensin-II induced perivascular fibrosis and cardiac dysfunction., Department of Pharmacology, Department of Pharmacology, UMMC | 02/2023 |
| Platform Presentations, Sex differences of endothelial Sirt3 in Angiotensin-II induced perivascular fibrosis and cardiac dysfunction, External Advisory Board (EAC) meeting, UMMC | 09/2022 |
| Poster Presentation, Ferrostatin-1 Ameliorates Cardiac Dysfunction in a Cardiomyocyte-Specific SIRTUIN 3 Knockout Mouse Model., AHA hypertension meeting, San Diego, CA | 09/2022 |
| Poster Presentation, Regulatory Role Of Endothelial Phd2 On Hypertensive Arterial Stiffness And Vascular Calcification. Vascular Discovery: From Genes to Medicine, Scientific Sessions, Seattle, WA | 05/2022 |
| Poster Presentation, Treatment with PFKFB3 inhibitor potentially improves diastolic function and arterial stiffness in PHD2ECKO mice., APS Physiology, Long Beach, LA | 04/2022 |
| Poster Presentation, Novel Regulatory Role Of SIRT3 On Cardiomyocyte Mitochondrial Frataxin And Ferroptosis., Experimental Biology Meeting, Philadelphia, PA | 04/2022 |
| State/Local Invited Seminars/Lectures, Sirt3 deficiency in blood pressure, diastolic dysfunction, and renal fibrosis. Department of Pharmacology, Department of Pharmacology, Department of Pharmacology, UMMC | 02/2022 |
| Platform Presentations, DEFICIENCY OF SIRTUIN3 DISRUPTS ENDOTHELIAL GLUCOSE METABOLISM AND SENSITIZES PRESSURE OVERLOADINDUCED HEART FAILURE, AHA Scientific sessions, philadelphia, PA | 11/2019 |
| Platform Presentations, Role of p53 acetylation in mediating myocardial angiogenesis and diabetic cardiomyopathy., AHA BCVS meeting, Boston, MA | 08/2019 |
| Poster Presentation, Deficiency of sirtuin 3 accentuates angiotensin ii-induced arterail stiffness/myocardial fibrosis and hypertension., Experimental Biology, Orlando, Florida | 04/2019 |
| Platform Presentations, regulatory role of endothelial sirt3 on blood pressure and diastolic dysfunction in a female mice., AHA council on hypertension, Chicago, IL | 09/2018 |
| Poster Presentation, ablation of endothelial sirt3 exacerbates pressure overload-induced heart failure., AHA BCVS meeting, San Antonio | 08/2018 |
| Platform Presentations, Sirtuin 3 attenuates diabetic cardiomyopathy via suppression of p53 acetylation and regulating cardiomyocyte metabolism., Experimental Biology, San Diego | 04/2018 |
| Poster Presentation, Deletion of endothelial Sirt3 causes diastolic dysfunction, AHA council on hypertension, San Francisco, CA | 09/2017 |
| Poster Presentation, Treatment with Prolyl Hydroxylase Inhibitor Reverses Pre-Existing Diastolic Dysfunction in the Aged SIRT3 Knockout Mice, EB meeting, Chicago | 04/2017 |
| Poster Presentation, Deletion of Endothelial Sirt3 Causes Coronary Microvascular Dysfunction and HFpEF., Experimental Biology, San Diego, CA | 04/2016 |
| Poster Presentation, Sirt3 regulates oxygen sensors and blood vessel formation in the heart., AHA, New Orleans, LA | 09/2013 |
| Platform Presentations, Sirt3 is essential for apelin-gene therapy mediated cardiac repair in post-myocardial infarction of diabetes., AHA meeting, New orleans | 09/2013 |
| Poster Presentation, SIRT3 Deficiency Impairs Hypoxic Signaling, Reprograms Basal Glycolytic Metabolism and Exacerbates Myocardial Ischemic Injury, Experimental Biology, Boston, MA | 04/2013 |
| Poster Presentation, Apelin-13 Increases Myocardial Progenitor Cells and Improves Myocardial Remodeling of Post-myocardial, AHA meeting, New orleans | 09/2012 |
| Poster Presentation, Apelin Reduces Myocardial Infarction Size and Promotes Angiogenesis by Increasing SDF-1/CXCR4 and AKT/eNOS/VEGF pathways, AHA meeting, Dallas | 07/2012 |
| Poster Presentation, Regulation Of Sirt3 And Autophagy By Bone Marrow Cells Therapy Improves Cardiac Repair In Post-myocardial Infarction Mice, AHA meeting, Dallas | 07/2012 |
| Poster Presentation, Ang-1 reduces myocardial infarction via upregulation of SDF-1/CXCR4 and recruiting hematopoietic progenitor cells in the diabetic db/db mouse model., AHA meeting, Orlando, FL | 11/2011 |
| Platform Presentations, Hypoxia/reoxygenation-induced myocardial angiogenesis: Role of NADPH oxidase derived reactive oxygen species (ROS), AHA meeting, CIRCULATION 114: 155-155; 2006., AHA meeting, Chicago | 11/2006 |
| Poster Presentation, Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis, FASEB JOURNAL 18: A385-A385; 2004., EB meeting, Washington DC | 03/2004 |
Honors, Awards, and Recognition
| Cells Best Paper Award, Cells, MDPI | 2025 |
| Excellence in Research Award (Bronze), The University of Mississippi Medical Center | 2023 |
Professional Membership and Service
| North American Vascular Biology organization, Member | 2023 - Present |
| American Physiology Society (APS), Member | 2023 - Present |
| American Heart Association (AHA), Member | 2020 - Present |
Committee Service
| Mentor member of CRRC T32 training grant, Member | 2023 - Present |
| Cardiac Discussion group of Physiology, Member | 2023 - Present |
| Cardiac grant review member of Physiology, Member | 2023 - Present |
| Co-Mentor, PhD student's Dissertation Committee Member of Pharmacology, Mentored students: Aubrey C Cantrell, Quinesha A Williams | 2020 - Present |
Other Service
| Journal of Cardiovascular Pharmacology | 08/2025 - Present |
| Editorial Review Board of Digital Chinese Medicine | 05/2024 - Present |
| International Journal of Medical Sciences | 05/2024 - Present |
| Journal of Advanced Research | 05/2024 - Present |
| JOVE Journal | 09/2023 - Present |
Teaching Experience
| 4, Medicine, Small Group, Facilitator, pharmacology small group | Fall 2021 - 2021 |
Directed Student Learning
| lab rotation, Advised: Olabisi O. Ogunlewe | 2025 - 2025 |
| Lab rotation, Advised: Ziru Niu | 2024 - 2025 |
| Supervised Research, Advised: Jacob Hearin | 2024 - 2024 |
| Supervised Research, Advised: Kendall Curry | 2023 - 2023 |
| Supervised Research, Advised: Savanna Sheppard | 2023 - 2023 |
| Supervised Research, Advised: Bryce Little | 2023 - 2023 |
| Supervised Research, Advised: Maxwell Pappas | 2022 - 2022 |
| Supervised Research, Advised: Jessie Besanson | 2022 - 2022 |
| Dissertation Committee Member, Endothelial PHD2 in heart failure Advised: Quinesha Williams | 2021 - Present |
| Dissertation Committee Member, Targeting ferroptosis in mitochondrial cardiomyopathy Advised: Aubrey C Cantrell | 2020 - 2024 |
| Lab rotation, Advised: Ubong S Ekperikpe | 2019 - 2019 |
| Lab rotation, Advised: Nathan E campbell | 2019 - 2019 |
| Supervised Research, The role of pericyte in hypertensive heart failure Advised: Han Su | 2018 - 2020 |
| lab rotation, Advised: Sumit Sontakke | 2017 - 2017 |
| lab rotation, Advised: Venkata Ramana Vaka | 2014 - 2015 |
| Supervised Research, The Role of Endothelial SIRT3 in Cardiac Hypertrophy and Heart Failure Advised: Xiaochen He | 2012 - 2017 |
Fellows supervised
| Research Advisor, 12 fellows supervised, G754, G325 | 10/2011 - 12/2024 |