Keli Xu, PhD
Associate Professor
Department:
SOM-Cell and Molecular Biology
Email:
kxu@umc.edu
Work Phone:
(601) 815-3083
Biography
Dr. Keli Xu received his Ph.D. in Biochemistry from Rutgers University and postdoctoral training in Developmental and Stem Cell Biology at the Hospital for Sick Children in Toronto. He joined UMMC in 2011 as Assistant Professor of Neurobiology and Anatomical Sciences with full membership in the Cancer Institute. Currently he is Associate Professor of Cell and Molecular Biology. Dr. Xu’s research interest focuses on the roles of Notch signaling in development and cancer, with over 40 peer-reviewed research articles including first or senior author papers in Neuron, Cancer Cell, Cancer Research, Oncogene, and Development. His research has been funded by National Cancer Institute and Department of Defense. Dr. Xu is an active reviewer for numerous journals and serves as grant reviewer for Breast Cancer Now (United Kingdom), Fund for Scientific Research (Belgium), Italian Ministry for Education, University and Research, and the Research Grant Council of Hong Kong.
Education
| Rutgers University, PhD, Biochemistry | 2001 |
| Shanghai Institute of Biochemistry, Chinese Academy of Sciences, MS, Molecular Biology | 1992 |
| Nanjing University, BS, Biochemistry | 1989 |
| The Hospital for Sick Children, Toronto, Postdoctoral Fellow, Developmental and Cancer Biology |
Current Positions
| Associate Professor, School of Medicine | 07/2020 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Mississippi Medical center, School of Medicine, Department of Neurobiology and Anatomical Sciences | 07/2011 - 06/2020 |
Sponsored Program Funding
| Extramural, Dissecting roles of Lunatic Fringe-dependent Notch signaling in pancreatic cancer, NIH/NCI | 05/2024 - 04/2029 |
| Extramural, Lunatic Fringe-modulated Notch signaling in pancreatic cancer, The Joe W. and Dorothy Dorsett Brown Foundation | 09/2019 - 08/2022 |
| Extramural, Exploiting the Twist1 network in cancer cachexia, NIH/NCI | 07/2019 - 06/2024 |
| Extramural, Notch3 as a tumor suppressor in the postpartum mammary gland, Department of Defense | 04/2019 - 12/2023 |
| Intramural, Roles of Lunatic Fringe in putative cell of origin and cancer stem cells of pancreatic cancer, UMMC | 09/2016 - 08/2017 |
| Extramural, Targeting multiple diseases through gamma secretase, NIH/NCI | 09/2013 - 08/2018 |
| Extramural, Pterostilbene, a potent analogue of resveratrol, as a therapeutic agent in prostate cancer: epigenetic mechanisms of action, Department of Defense | 09/2013 - 08/2016 |
| Extramural, Functional analysis of Manic Fringe in the claudin-low breast cancer, NIH/NCI | 04/2013 - 03/2016 |
Publications
Journal Article | |
| Chung WC, Zhang S, Atfi A, Xu K. Lfng-expressing centroacinar cell is a unique cell-of-origin for p53 deficient pancreatic cancer Oncogene. 2024 Nov 15. doi: 10.1038/s41388-024-03226-7. Online ahead of print. | 2024 |
| Hossain F, Ucar DA, Monticone G, Ran Y, Majumder S, Larter K, Luu H, Wyczechowska D, Heidari S, Xu K, Shanthalingam S, Matossian M, Xi Y, Burow M, Collins-Burow B, Del Valle L, Hicks C, Zabaleta J, Golde T, Osborne B, Miele L. Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer Front Immunol. 2023;13:14:1244159. | 2023 |
| Hurwitz E, Parajuli P, Ozkan S, Prunier C, Nguyen TL, Campbell D, Friend C, Bryan A, Lu T-X, Razzaque MS, Xu K, Atfi A. Antagonism between Prdm16 and Smad4 specifies the trajectory and fitness of pancreatic cancer J Cell Biol. 2023;222(4):e202203036 | 2023 |
| Ramakrishnan G, Parajuli P, Singh P, Friend C, Hurwitz E, Prunier C, Razzaque MS, Xu K, Atfi A. NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma Cell Rep. 2022;41(6):111623 | 2022 |
| Chung W-C, Egan SE, Xu K. A tumor-suppressive function for Notch3 in the parous mammary gland Development. 2022;149(19):dev200913 | 2022 |
| Monticone G, Huang Z, Csibi F, Leit S, Ciccone D, Champhekar AS, Austin JE, Ucar DA, Hossain F, Ibba SV, Boulares AH, Carpino N, Xu K, Majumder S, Osborne BA, Loh C, Miele L. Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses Front Immunol. 2022;13:987298 | 2022 |
| Wang X, Xu K, Wang J, Zhou Y LCLE: a web portal for lncRNA network analysis in liver cancer Int. J. Computational Biology and Drug Design. 2020;13(5/6):520-528. | 2021 |
| Chung W-C, Challagundla L, Zhou Y, Li M, Atfi A, Xu K Loss of Jag1 cooperates with mutant Kras to induce pancreatic cystic neoplasm Life Science Alliance. 2020;4(2):e201900503. | 2021 |
| Chung W-C, Zhou X, Atfi A, Xu K Pik3cg is a potential therapeutic target in androgen receptor-indifferent metastatic prostate cancer Am J Pathol. 2020;190(11):2194-2202. | 2020 |
| Wang J, Wang X, Chen Y, Xu X, Mo Y-Y, Yi S, Zhou Y Comprehensive network analysis reveals alternative splicing-related lncRNAs in hepatocellular carcinoma Front Genet. 2020;11:659. | 2020 |
| Nguyen TL, Parajuli P, Prunier C, Razzaque MS, Xu K, Atfi A Pancreatic cancer triggers diabetes through TGF-b-mediated selective depletion of islet b-cells Life Science Alliance. 2020;3(6):e201900573. | 2020 |
| Chang J, Hong L, Liu Y, Pan Y, Yang H, Ye W, Xu K, Li Z, Zhang S Targeting PIK3CG in combination with paclitaxel as a potential therapeutic regimen in claudin-low breast cancer Cancer Management and Research. 2020;12:2641-2651. | 2020 |
| Chung W-C, Zhou Y, Atfi A, Xu K. Downregulation of Notch signaling in Kras-induced gastric metaplasia Neoplasia. 2019; 21:810-821 | 2019 |
| Parajuli P, Singh P, Wang Z, Li L, Eragamreddi S, Ozkan S, Ferrigno O, Prunier C, Razzaque MS, Xu K, Atfi A. TGIF1 functions as a tumor suppressor in pancreatic ductal adenocarcinoma EMBO J. 2019 Jul 1;38(13):e101067. doi: 10.15252/embj.2018101067. Epub 2019 May 31. | 2019 |
| Zhang S, Wang J, Xu K, York M, Mo Y-Y, Chen Y, Zhou Y A comparative study of multiclass feature selection on RNAseq and microarray data International Journal of Computational Biology and Drug Design. 2019;12(2):128-142 | 2019 |
| Garg A, Hannan A, Wang Q, Collins T, Teng S, Bansal M, Zhong J, Xu K, Zhang X FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination PLOS Genetics. 2018;14(9):e1007660 | 2018 |
| Murthy PKL, Srinivasan T, Bochter MS, Xi R, Varanko AK, Tung KL, Semerci F, Xu K, Maletic-Savatic M, Cole SE, Shen X Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis eLife. 2018 Apr 9;7. pii: e35710 | 2018 |
| Zhang S, Liu J, Xu K, Li Z Notch signaling via regulation of RB and p-AKT but not PIK3CG contributes to MIA PaCa-2 cell growth and migration to affect pancreatic carcinogenesis Oncol Lett. 2018;15(2):2105-2110 | 2018 |
| Chung W-C, Zhang S, Challagundla L, Zhou Y, Xu K Lunatic Fringe and p53 cooperatively suppress mesenchymal stem-like breast cancer Neoplasia. 2017;19(11):885-895 | 2017 |
| Chung W-C, Wang J, Zhou Y, Xu K KrasG12D upregulates Notch signaling to induce gallbladder tumorigenesis in mice Oncoscience. 2017;4(9-10):131-38 | 2017 |
| Zhang S, Chung W-C, Xu K Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer Oncogene. 2016; 35(19):2485-95 | 2016 |
| Zhang S, Chung W-C, Wu G, Egan SE, Miele L, Xu K Manic Fringe promotes a claudin-low breast cancer phenotype through Notch-mediated PIK3CG induction Cancer Res. 2015; 75(10):1936-43 | 2015 |
| Zhang S, Chung W-C, Miele L, Xu K Targeting Met and Notch in the Lfng-deficient, Met-amplified triple negative breast cancer Cancer Biol Ther. 2014; 15(5):633-42 | 2014 |
| Zhang S, Chung W-C, Wu G, Egan SE, Xu K Tumor suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation Neoplasia. 2014; 16(2):158-167 | 2014 |
| Zhang S, Loch AJ, Radtke F, Egan SE, Xu K Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways Dev Dyn. 2013; 242(6):678-86 | 2013 |
| Xu K, Usary J, Kousis P, Prat A, Wang D-Y, Adams JR, Wang W, Loch AJ, Deng T, Zhao W, Cardiff RD, Yoon K, Gaiano N, Ling V, Beyene J, Zacksenhaus E, Gridley T, Leong WL, Guidos CJ, Perou CM, Egan SE Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer Cancer Cell. 2012; 21(5):626-41 | 2012 |
| Suliman S, Tan J, Xu K, Kousis PC, Kowalski PE, Chang G, Egan SE, Guidos C Notch3 is dispensable for thymocyte b-selection and Notch1-induced leukemogenesis PLoS One. 2011; 6(9): e24937 | 2011 |
| Raafat A, Goldhar AS, Klauzinska M, Xu K, Amirjazil I, McCurdy D, Salomon D, Vonderhaar BK, Egan SE, Callahan R Expression of Notch receptors, ligands and target genes during development of the mouse mammary gland J Cell Physiol. 2011; 226(7):1940-52. | 2011 |
| Adams JR, Xu K, Liu JC, Agamez NR, Loch AJ, Wong RG, Wang W, Wright KL, Lane TF, Zacksenhaus E, Egan SE Cooperation between PIK3Cα and p53 mutations in mouse mammary tumor formation Cancer Res. 2011; 71(7):2706-2717 | 2011 |
| Yuan JS, Tan JB, Visan I, Matei IR, Urbanellis P, Xu K, Danska JS, Egan SE, Guidos CJ Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors Blood. 2011; 117(4):1184-95 | 2011 |
| Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis Am J Physiol Lung Cell Mol Physiol. 2010; 298:L45-56. | 2010 |
| Tan JB, Xu K, Cretegny K, Visan I, Yuan JS, Egan SE, Guidos CJ Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches Immunity. 2009; 30:254-63 | 2009 |
| Wang W, Bouhours M, Gracheva EO, Liao EH, Xu K, Sengar AS, Xin X, Roder J, Boone C, Richmond JE, Zhen M, Egan SE ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1 Traffic. 2008; 9:742-54. | 2008 |
| Syntichaki P, Xu K, Driscoll M, Tavernarakis N Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans Nature. 2002; 419:939-44 | 2002 |
| Xu K, Tavernarakis N, Driscoll M Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca2+ release from the endoplasmic reticulum Neuron. 2001; 31:957-971 | 2001 |
| Xu K, Yu X, Kong Y, Wang Y, Li Z HBV surface antigen proteins with deletions in the preS region Sci China B. 1995; 38:320-327. | 1995 |
Review Article | |
| Chung W-C, Xu K. Notch signaling pathway in pancreatic tumorigenesis Adv Cancer Res. 2023;159:1-36 | 2023 |
| Xu K Breast cancer regulated by Fringe Oncoscience. 2015; 2(10):829-30 | 2015 |
| Xu K, Bägli DJ, Egan SE NOTch just a bladder control problem Cancer Cell. 2014; 26(4):452-54 | 2014 |
| Xu K, Moghal N, Egan SE Notch signaling in lung development and disease Adv Exp Med Biol. 2012; 727:89-98 | 2012 |
| Xu K, Yu X Biological functions of the HBV surface antigen proteins preS region Foreign Medicine Ser. Molecular Biology (China). 1992; 14:185-188 | 1992 |
Book Chapter | |
| Xu K, Egan SE Out on the Fringe: Modulation of Notch Signaling by Glycosylation Targeting Notch in Cancer: From the Fruit Fly to the Clinic. Edited by Miele L and Artavanis-Tsakonas S. Springer Nature. 2018, p. 87-126 | 2018 |
| Xu K, Moghal N, Egan SE Notch Signaling in Lung Development and Disease Notch Signaling in Embryology and Cancer. Edited by Reichrath J and Reichrath S. Springer. 2011. p. 89-98 | 2012 |
Presentations
| Poster Presentation, Notch3 functions as a tumor suppressor in ER-positive breast cancer, AACR 2021 Annual Meeting, Virtual Meeting | 04/2021 |
| Poster Presentation, Investigating tumor infiltrating immune cells signature in obese triple negative breast cancer, AACR Annual Meeting 2020, Philadelphia, PA | 04/2020 |
| Poster Presentation, Expression of Lunatic Fringe in endogenous stem cells after spinal cord injury in mice, Summer Undergraduate Research Symposium, University of Mississippi Medical Center | 08/2019 |
| Platform Presentations, LCLE: a web portal for comprehensive gene distance analysis for correlation networks in liver cancer, International Conference on Intelligent Biology and Medicine, Columbus, OH | 06/2019 |
| Poster Presentation, Repurposing sulindac sulfide as a notch inhibitor to target cancer stem-like cells in triple negative breast cancer, 2018 San Antonio Breast Cancer Symposium, San Antonio, Texas | 12/2018 |
| Poster Presentation, A phenotypical switch between pancreatic ductal adenocarcinoma and cystic neoplasms regulated by Jagged1, Gordon Research Conference: Notch Signaling in Development, Regeneration and Disease, Bates College in Lewiston, ME | 07/2018 |
| Invited Symposia, Fringe-modulated Notch signaling in the oncogenesis of breast, prostate, and pancreas, Scientific Retreat of the Cancer Institute, University of Mississippi Medical Center, Jackson, MS | 06/2018 |
| Poster Presentation, A tumor suppressive role of Jagged1 in Kras-induced pancreatic cancer, Gordon Research Conference: Pancreatic Diseases, Waterville Valley, NH | 06/2017 |
| Poster Presentation, Identifying progression of aggressive prostate cancer originating from Lunatic Fringe/Notch‐regulated mice models, Emerging Researchers National (ERN) Conference in STEM, Washington, DC | 03/2017 |
| Poster Presentation, Tgif inactivation defines a synthetic lethal interaction among oncogenic Kras and Twist1 in pancreatic ductal adenocarcinoma, Proceedings of the AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer, San Diego, CA | 01/2017 |
| Poster Presentation, Identifying progression of aggressive prostate cancer originating from Lunatic Fringe/Notch‐regulated mice models, Annual Biomedical Research Conference for Minority Students, Tampa, FL | 11/2016 |
| Invited Symposia, Potential roles of Lunatic Fringe and Notch in aggressive prostate cancer, 2016 Prostate Cancer Research Mini Symposium, University of Mississippi Medical Center | 08/2016 |
| Platform Presentations, Identifying progression of aggressive prostate cancer originating from Lunatic Fringe/Notch‐regulated mice models, 2016 Prostate Cancer Research Mini Symposium, University of Mississippi Medical Center | 08/2016 |
| National and International Invited Seminars/Lectures, Fringe modulated Notch signaling in cancer cell-of-origin and cancer stem cells of multiple tissues, State Key Laboratory of Medical Genetics and School of Life Sciences, Central South University, Changsha, China | 06/2016 |
| Poster Presentation, Lunatic Fringe and p53 cooperatively prevent development of claudin-low breast cancer, AACR 2016 Annual Meeting, New Orleans, Louisiana | 04/2016 |
| Platform Presentations, Effects of Notch3 in aggressiveness of prostate cancer, 2015 Prostate Cancer Research Mini Symposium, University of Mississippi Medical Center | 07/2015 |
| National and International Invited Seminars/Lectures, Out on the Fringe: How Lunatic and Manic Fringes conspire to change the destiny of cells, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center | 05/2015 |
| State/Local Invited Seminars/Lectures, Fringe-modulated Notch: a developmental signaling pathway in cells-of-origin for cancer and cancer stem cells, UMMC Hematology/Oncology Fellows’ Research Conference, University of Mississippi Medical Center | 11/2014 |
| Poster Presentation, A tumor-suppressive role of Lunatic Fringe through crosstalk between Notch and TGF-β in pancreatic cancer, 14th Oncology Meeting of The Chinese Association of Pathophysiology, Hangzhou, China | 11/2014 |
| Poster Presentation, The role of Met amplification and Lfng deletion in the development of basal-like breast cancers, 15th International Biennial Congress of the METASTASIS RESEARCH SOCIETY, Heidelberg, Germany | 06/2014 |
| Poster Presentation, A tumor-suppressive role of Lunatic Fringe through crosstalk between Notch and TGF-β in pancreatic cancer, UMMC Research Day 2014, University of Mississippi Medical Center | 04/2014 |
| Poster Presentation, Targeting Notch and c-Met in the basal-like and claudin-low breast cancer models, UMMC Cancer Research Day, University of Mississippi Medical Center | 11/2012 |
| Invited Symposia, Fringe-Modulated Notch Activation in the Triple Negative Breast Cancer, UMMC Cancer Research Day, University of Mississippi Medical Center | 11/2012 |
| State/Local Invited Seminars/Lectures, Fringe-modulated Notch signaling in mammary development and breast cancer, UMMC Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center | 10/2012 |
| State/Local Invited Seminars/Lectures, Fringes and Notch signaling in mammary development and breast cancer, UMMC Department of Pharmacology and Toxicology, University of Mississippi Medical Center | 01/2012 |
| Poster Presentation, Alteration of Notch-Dependent Hematopoietic Stem Cell Fates by Fringe Glycosyltransferases, Annual Conference of the Society for Glycobiology, St. Pete Beach, FL | 11/2010 |
| State/Local Invited Seminars/Lectures, Notch signaling in lung alveogenesis, mammary gland development and breast cancer, UMMC Cancer Institute, University of Mississippi Medical Center | 07/2010 |
| State/Local Invited Seminars/Lectures, Lunatic Fringe controls Notch activation in mammary basal cells and functions as a tumor suppressor, Campbell Family Cancer Research Institute, Toronto, Canada | 04/2010 |
| State/Local Invited Seminars/Lectures, Genetic analysis of Lfng-dependent Notch signaling in mammary gland, Campbell Family Cancer Research Institute, Toronto, Canada | 03/2007 |
| Poster Presentation, Notch activation/signaling in breast cancer, Gordon Research Conference on Mammary Gland Biology, Lucca (Barga), Italy | 05/2006 |
| State/Local Invited Seminars/Lectures, Regulation of mammary gland development and breast cancer by Notch signaling, Campbell Family Cancer Research Institute, Toronto, Canada | 03/2006 |
| Platform Presentations, Lunatic Fringe controls Notch signaling to promote pulmonary vascular development and alveogenesis, Great Lakes Mammalian Development Meeting, Toronto, Canada | 03/2006 |
| Poster Presentation, Genetic Analysis of Fringe genes in mammary development and breast cancer, US Army Conference Washington DC 2004, Washington DC | 01/2004 |
| Poster Presentation, Regulation of mammary gland development and breast cancer by Notch activation, Gordon Research Conference on Mammary Gland Biology, Roger Williams University | 06/2003 |
| Poster Presentation, One goal-three approaches: exploring genetics of necrotic-like cell death in C. elegans, 2002 East Coast Worm Meeting, University of New Hampshire, Durham, NH | 06/2002 |
| Platform Presentations, mec-4(d)-induced necrotic-like cell death in C. elegans requires calreticulin and regulators of ER-mediated Ca2+ release, 13th International C. elegans Meeting, University of California, Los Angeles | 06/2001 |
| Platform Presentations, Execution of necrotic-like cell death in C. elegans requires the activity of specific aspartyl proteases, 13th International C. elegans Meeting, University of California, Los Angeles | 06/2001 |
| Poster Presentation, Exploring necrotic cell death in C. elegans, 13th International C. elegans Meeting, Univertsity of California, Los Angeles | 06/2001 |
| Poster Presentation, Necrotic neurodegeneration in Caenorhabditis elegans, Miami Nature Biotechnology Winter Symposium "Cell Death and Aging", Miami Beach, FL | 02/2001 |
| Poster Presentation, Execution of necrotic-like cell death in Caenorhabditis elegans requires cathepsin D activity, Miami Nature Biotechnology Winter Symposium "Cell Death and Aging", Miami Beach, FL | 02/2001 |
| Platform Presentations, Mutations that suppress degenerative cell death can extend lifespan, 12th International C. elegans Meeting, University of Wisconsin, Madison, WI | 06/1999 |
| Platform Presentations, Suppressors of degenerative cell death can also affect aging, 1998 East Coast Worm Meeting, Boston University, Boston, MA | 06/1998 |
| Poster Presentation, A suppressor of degenerative cell death extends lifespan in C. elegans, 1998 East Coast Worm Meeting, Boston University, Boston, MA | 06/1998 |
| Poster Presentation, Genetic dissection of neurodegenerative death mechanisms, 11th International C. elegans Meeting, University of Wisconsin, Madison, WI | 06/1997 |
| Poster Presentation, unc-8 encodes a degenerin expressed in motorneurons and nose touch receptors, 1996 East Coast C. elegans Meeting, Rutgers University, New Brunswick, NJ | 06/1996 |
| Poster Presentation, An Anti-death Crusade: Screening for Suppressors of mec-4 (d)-induced Neurodegeneration, 1996 East Coast C. elegans Meeting, Rutgers University, New Brunswick, NJ | 06/1996 |
| Invited Symposia, Reduce, Reuse, Recycle: Repurposing NSAIDS to Inhibit Inflammation and Enhance Tumor Immunity in Cancer, 2018 Salerno Medical School Symposium, Salerno, Italy |
Honors, Awards, and Recognition
| Excellence in Research Award (Gold), University of Mississippi Medical Center | 2024 |
| Cancer Researcher of the Year, UMMC Cancer Center and Research Institute | 2024 |
| Excellence in Research Award (Silver), University of Mississippi Medical Center | 2019 |
| Excellence in Research Award (Bronze), University of Mississippi Medical Center | 2014 |
| Xu K, Usary J, Kousis P, Prat A, Wang D-Y, Adams JR, Wang W, Loch AJ, Deng T, Zhao W, Cardiff RD, Yoon K, Gaiano N, Ling V, Beyene J, Zacksenhaus E, Gridley T, Leong WL, Guidos CJ, Perou CM, Egan SE. 2012, Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell. 21(5):626-41. Recommended by Faculty of 1000, Faculty of 1000 | 2012 |
| Tan JB, Xu K, Cretegny K, Visan I, Yuan JS, Egan SE, Guidos CJ. 2009, Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity. 30:254-63. Recommended by Faculty of 1000, Faculty of 1000 | 2009 |
| CIHR Postdoctoral Fellowship, Canadian Institutes of Health Research (CIHR) | 2003 |
| Syntichaki P, Xu K, Driscoll M, Tavernarakis N. 2002, Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature 419:939-44. Recommended by Faculty of 1000, Faculty of 1000 | 2002 |
| Restracomp Fellowship, The Hospital for Sick Children, Toronto | 2001 |
| Research Achievement Award, Robert Wood Johnson Medical School | 2001 |
| President's Award, Chinese Academy of Sciences | 1993 |
Professional Membership and Service
| American Association for Cancer Research (AACR), Member | 2015 - Present |
| Asia-Pacific Association of Medical Research (APAMR), Member | 2015 - Present |
Committee Service
| Mentoring Committee for Junior Faculty (Dr. Ramona Moles ), Member | 2024 - Present |
| Graduate Committee of Cell and Molecular Biology, Member | 2023 - Present |
| Promotion and Tenure committee, Dept. of Neurobiology and Anatomical Sciences, Member | 2020 - 2022 |
| Scientific Leadership Council of the UMMC Cancer Institute, Member | 2018 - Present |
| MEDICAL CENTER-ANIMAL CARE AND USE, Member | 2013 - 2019 |
Community Service
| Served as a mentor in the ‘Summer of Research’ Medical Student Research Program (MSRP), Mentor | 06/2023 - 07/2023 |
| Served as a mentor in the UMMC's SURE program, Mentor | 06/2022 - 08/2022 |
| Served as a mentor in Mississippi Prostate Cancer HBCU Undergraduate Research Training Program, Mentor | 05/2016 - 08/2016 |
| Served as a mentor in Mississippi Prostate Cancer HBCU Undergraduate Research Training Program, Mentor | 05/2015 - 07/2015 |
| Served as a mentor for a graduate student from Mississippi College (as Research Volunteer), Mentor | 08/2014 - 07/2015 |
Other Service
| Gastrointestinal Cancer Working Group, Leader | 12/2024 - Present |
| The Fund for Scientific Research-FNRS (Belgium) | 08/2024 - 09/2024 |
| Breast Cancer Now (United Kingdom) | 08/2024 - 08/2024 |
| UMMC Intramural Research Support Program | 05/2023 - 07/2023 |
| Frontiers in Oncology | 07/2022 - Present |
| UMMC Intramural Research Support Program | 09/2021 - 11/2021 |
| Panel Reviewer for Jackson State University Research Centers in Minority Institutions (RCMI)-Center for Health Disparities Research (CHDR) Pilot Project Program | 11/2020 - 12/2020 |
| External reviewer for faculty promotion and tenure at Virginia Commonwealth University | 06/2020 - 07/2020 |
| The Italian Ministry for Education, University and Research | 09/2018 - 10/2018 |
| Scientific Leadership Council of the Cancer Institute, Member | 03/2018 - Present |
| Journal of Cancer Metastasis and Treatment, Editorial Board Member | 05/2015 - 05/2017 |
| The Research Grant Council of Hong Kong | 03/2015 - 03/2015 |
| Cancer Institute “Grant in Progress” Meeting, Coordinator | 10/2013 - 09/2014 |
| The Research Grant Council of Hong Kong, Reviewer, Grant Proposal | 04/2013 - 04/2013 |
| Cancer Research Day, Session Chair | 11/2012 - 11/2012 |
| Oncogene | |
| American Journal of Pathology | |
| Physiological Genomics | |
| FEBS Letters, Reviewer, Journal Article | |
| Cellular Signaling, Reviewer, Journal Article | |
| Frontiers in Oncology, Reviewer, Journal Article | |
| Molecular Cancer Therapeutics, Reviewer, Journal Article | |
| Cellular Physiology and Biochemistry, Reviewer, Journal Article | |
| International Journal of Molecular Sciences, Reviewer, Journal Article | |
| Cancers, Reviewer, Journal Article | |
| Cancer Letters, Reviewer, Journal Article | |
| Molecular Cancer, Reviewer, Journal Article | |
| Current Drug Targets, Reviewer, Journal Article | |
| Oncotarget, Reviewer, Journal Article | |
| Stem Cells, Reviewer, Journal Article |
Teaching Experience
| CMB740, Graduate, Lecture, Lecturer, Cell and Molecular Biology Methods | Fall 2024 - 2024 |
| SOM610, Medicine, Course, Course Presenter, Fundamentals of Biomedical Sciences | Fall 2024 |
| CMB740, Graduate, Lecture, Lecturer, Cell and Molecular Biology Methods | Fall 2023 - 2023 |
| SOM610, Medicine, Course, Course Presenter, Fundamentals of Biomedical Sciences | Fall 2023 |
| CMB744, Graduate, Lecture, Lecturer, Cell and Molecular Biology | Spring 2023 - 2023 |
| CMB740, Graduate, Lecture, Lecturer, Cell and Molecular Biology Methods | Fall 2022 - 2022 |
| ANAT 613, Medicine, Course, Course Presenter, Medical Histology and Cell Biology | Fall 2022 |
| ANAT 613, Medicine, Course, Course Presenter, Medical Histology and Cell Biology | Fall 2021 |
| ANAT 613, Medicine, Course, Course Presenter, Medical Histology and Cell Biology | Fall 2020 |
| Medicine, Course, Guest Presenter, Medical Histology and Cell Biology | Fall 2019 - 2019 |
| Medicine, Course, Guest Presenter, Medical Histology and Cell Biology | Fall 2018 - 2018 |
| PATH 748, Graduate, Course, Lecturer, Problems in Cancer Biology | Spring 2017 - 2017 |
| Medicine, Course, Guest Presenter, Medical Histology and Cell Biology | Fall 2017 - 2017 |
| CONJ 611, Medicine, Lab, Facilitator, Medical Neurobiology | Spring 2016 - 2016 |
| Medicine, Course, Guest Presenter, Medical Histology and Cell Biology | Fall 2016 - 2016 |
| Graduate, Course, Lecturer, Molecular Oncology | Spring 2015 - 2015 |
| Medicine, Lecture, Guest Presenter, Hematology/Oncology Fellows’ Research Conference | Fall 2014 - 2014 |
| Graduate, Course, Lecturer, Molecular Oncology | Spring 2013 - 2013 |
Directed Student Learning
| Research Advisor, Wnt and Notch crosstalk in pregnancy-associated breast cancer Advised: Charles Moore | 2024 - Present |
| Supervisor for rotation student, Advised: Ali Akbari | 2024 - 2024 |
| Supervisor for rotation student, Advised: Charles Moore | 2023 - 2024 |
| Research Advisor, Advised: Jalexis Evans | 2023 - 2023 |
| Research Advisor, Advised: Likhitha Polepalli | 2022 - 2022 |
| Dissertation Committee Member, MHC class I polypeptide related sequence A (MICA) in the context of aggressive prostate cancer Advised: Marcelo Sakiyama | 2016 - 2019 |
| Research Advisor, Advised: Courtney Mangum | 2016 - 2016 |
| Research Advisor, Advised: Deion Fields | 2015 - 2015 |
| Research Advisor, Advised: Megan Fuller | 2014 - 2015 |
| Dissertation Committee Member, Advised: Kandis Backus | 2013 - 2013 |
| Supervisor for rotation student, Advised: Chen Liu | 2013 - 2013 |
Fellows supervised
| Cell and Molecular Biology, Research Advisor, 1 fellows supervised | 10/2024 - Present |
| Tumor Cell Biology, Research Advisor, 1 fellows supervised | 04/2013 - 03/2016 |
| Tumor Cell Biology, Research Advisor, 1 fellows supervised | 03/2012 - 07/2014 |