Jan M. Williams, PhD
Professor
Department:
SOM-Pharmacology/Toxicology
Email:
jmwilliams5@umc.edu
Work Phone:
(601) 984-1175
Education
| Medical College of Wisconsin, Postdoctoral Fellowship, Hypertension-induced renal disease | 2009 |
| Medical College of Georgia, PhD, Biomedical Sciences | 2005 |
| Georgia Southern University, BS, Chemistry | 1999 |
Current Positions
| Associate Professor, School of Medicine, Department of Pharmacology / Toxicology | 07/2015 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 10/2009 - 06/2015 |
| Assistant Professor, Medical College of Wisconsin, School of Graduate, Department of Physiology And Biophysics | 05/2009 - 09/2009 |
Sponsored Program Funding
| Extramural, Mechanisms involved in the early development of renal disease associated with prepubertal obesity, NIDDK | 06/2017 - 04/2022 |
| Extramural, Cardiorenal and Metabolic Disease Center, NIH | 09/2013 - 04/2018 |
| Extramural, Discovering new therapies for the treatment of diabetic nephropathy, AHA | 01/2012 - 12/2015 |
| Extramural, Matrix Metalloproteinases in Diabetic Nephropathy, PhRMA Foundation | 01/2011 - 12/2011 |
| Intramural, Mechanisms of Diabetic Nephropathy, UMMC | 11/2010 - 10/2011 |
| Extramural, Blood Pressure: Determinants and Controllers, NIH | 09/2009 - 08/2011 |
Publications
Journal Article | |
| McPherson KC, Shields CA, Poudel B, Fizer B, Pennington A, Szabo-Johnson A, Thompson WL, Cornelius DC, Williams JM, Impact of obesity as an independent risk factor for the development of renal injury: implications from rat models of obesity. American journal of physiology. Renal physiology, 2019 Feb 1;316(2):F316-F327 | 2019 |
| Travis OK, White D, Pierce WA, Ge Y, Stubbs CY, Spradley FT, Williams JM, Cornelius DC, Chronic infusion of interleukin-17 promotes hypertension, activation of cytolytic natural killer cells, and vascular dysfunction in pregnant rats. Physiological reports, 2019 Apr;7(7):e14038 | 2019 |
| Cornelius DC, Baik CH, Travis OK, White DL, Young CM, Austin Pierce W, Shields CA, Poudel B, Williams JM, NLRP3 inflammasome activation in platelets in response to sepsis. Physiological reports, 2019 May;7(9):e14073 | 2019 |
| Zhang C, He X, Murphy SR, Zhang H, Wang S, Ge Y, Gao W, Williams JM, Geurts AM, Roman RJ, Fan F, Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury. The Journal of pharmacology and experimental therapeutics, 2019 Aug;370(2):206-217 | 2019 |
| Cunningham MW Jr, Castillo J, Ibrahim T, Cornelius DC, Campbell N, Amaral L, Vaka VR, Usry N, Williams JM, LaMarca B, AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) Blockade Prevents Preeclamptic Symptoms in Placental Ischemic Rats. Hypertension (Dallas, Tex. : 1979), 2018 May;71(5):886-893 | 2018 |
| Shields CA, McCalmon M, Ibrahim T, White DL, Williams JM, LaMarca B, Cornelius DC, Placental ischemia-stimulated T-helper 17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy. American journal of physiology. Regulatory, integrative and comparative physiology, 2018 Aug 1;315(2):R336-R343 | 2018 |
| Spires D, Poudel B, Shields CA, Pennington A, Fizer B, Taylor L, McPherson KC, Cornelius DC, Williams JM, Prevention of the progression of renal injury in diabetic rodent models with preexisting renal disease with chronic endothelin A receptor blockade. American journal of physiology. Renal physiology, 2018 Oct 1;315(4):F977-F985 | 2018 |
| Wang Z, do Carmo JM, Aberdein N, Zhou X, Williams JM, da Silva AA, Hall JE, Synergistic Interaction of Hypertension and Diabetes in Promoting Kidney Injury and the Role of Endoplasmic Reticulum Stress. Hypertension (Dallas, Tex. : 1979), 2017 May;69(5):879-891 | 2017 |
| Morris R, Spencer SK, Kyle PB, Williams JM, Harris A, Owens MY, Wallace K, Hypertension in an Animal Model of HELLP Syndrome is Associated With Activation of Endothelin 1. Reproductive sciences (Thousand Oaks, Calif.), 2016 Jan;23(1):42-50 | 2016 |
| Wang X, Johnson AC, Sasser JM, Williams JM, Solberg Woods LC, Garrett MR, Spontaneous one-kidney rats are more susceptible to develop hypertension by DOCA-NaCl and subsequent kidney injury compared with uninephrectomized rats. American journal of physiology. Renal physiology, 2016 May 1;310(10):F1054-64 | 2016 |
| Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A, p66Shc regulates renal vascular tone in hypertension-induced nephropathy. The Journal of clinical investigation, 2016 Jul 1;126(7):2533-46 | 2016 |
| McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM, Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. American journal of physiology. Renal physiology, 2016 Oct 1;311(4):F793-F804 | 2016 |
| Bean C, Spencer SK, Bowles T, Kyle PB, Williams JM, Gibbens J, Wallace K, Inhibition of T-cell activation attenuates hypertension, TNFα, IL-17, and blood-brain barrier permeability in pregnant rats with angiogenic imbalance. American journal of reproductive immunology (New York, N.Y. : 1989), 2016 Oct;76(4):272-9 | 2016 |
| Cunningham MW Jr, Williams JM, Amaral L, Usry N, Wallukat G, Dechend R, LaMarca B, Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor Enhance Angiotensin II-Induced Renal Vascular Sensitivity and Reduce Renal Function During Pregnancy. Hypertension (Dallas, Tex. : 1979), 2016 Nov;68(5):1308-1313 | 2016 |
| Wang X, Johnson AC, Williams JM, White T, Chade AR, Zhang J, Liu R, Roman RJ, Lee JW, Kyle PB, Solberg-Woods L, Garrett MR, Nephron Deficiency and Predisposition to Renal Injury in a Novel One-Kidney Genetic Model. Journal of the American Society of Nephrology : JASN, 2015 Jul;26(7):1634-46 | 2015 |
| Gillis EE, Williams JM, Garrett MR, Mooney JN, Sasser JM, The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia. American journal of physiology. Regulatory, integrative and comparative physiology, 2015 Jul 1;309(1):R62-70 | 2015 |
| Kojima N, Williams JM, Slaughter TN, Kato S, Takahashi T, Miyata N, Roman RJ, Renoprotective effects of combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats. Physiological reports, 2015 Jul;3(7) | 2015 |
| Fan F, Chen CC, Zhang J, Schreck CM, Roman EA, Williams JM, Hirata T, Sharma M, Beard DA, Savin VJ, Roman RJ, Fluorescence dilution technique for measurement of albumin reflection coefficient in isolated glomeruli. American journal of physiology. Renal physiology, 2015 Dec 15;309(12):F1049-59 | 2015 |
| Westbrook L, Johnson AC, Regner KR, Williams JM, Mattson DL, Kyle PB, Henegar JR, Garrett MR, Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. Journal of the American Society of Nephrology : JASN, 2014 Nov;25(11):2499-510 | 2014 |
| Ge Y, Murphy SR, Fan F, Williams JM, Falck JR, Liu R, Roman RJ, Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats. American journal of physiology. Renal physiology, 2014 Sep 1;307(5):F509-15 | 2014 |
| Burke M, Pabbidi M, Fan F, Ge Y, Liu R, Williams JM, Sarkis A, Lazar J, Jacob HJ, Roman RJ, Genetic basis of the impaired renal myogenic response in FHH rats. American journal of physiology. Renal physiology, 2013 Mar 1;304(5):F565-77 | 2013 |
| Kojima N, Williams JM, Takahashi T, Miyata N, Roman RJ, Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats. The Journal of pharmacology and experimental therapeutics, 2013 Jun;345(3):464-72 | 2013 |
| Mathis KW, Venegas-Pont M, Flynn ER, Williams JM, Maric-Bilkan C, Dwyer TM, Ryan MJ, Hypertension in an experimental model of systemic lupus erythematosus occurs independently of the renal nerves. American journal of physiology. Regulatory, integrative and comparative physiology, 2013 Oct 1;305(7):R711-9 | 2013 |
| Slaughter TN, Paige A, Spires D, Kojima N, Kyle PB, Garrett MR, Roman RJ, Williams JM, Characterization of the development of renal injury in Type-1 diabetic Dahl salt-sensitive rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2013 Oct 1;305(7):R727-34 | 2013 |
| Kojima N, Slaughter TN, Paige A, Kato S, Roman RJ, Williams JM, Comparison of the Development Diabetic Induced Renal Disease in Strains of Goto-Kakizaki Rats. Journal of diabetes & metabolism, 2013 May 30;Suppl 9(5) | 2013 |
| Williams JM, Fan F, Murphy S, Schreck C, Lazar J, Jacob HJ, Roman RJ, Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2012 May 15;302(10):R1209-18 | 2012 |
| Murphy SR, Dahly-Vernon AJ, Dunn KM, Chen CC, Ledbetter SR, Williams JM, Roman RJ, Renoprotective effects of anti-TGF-β antibody and antihypertensive therapies in Dahl S rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2012 Jul 1;303(1):R57-69 | 2012 |
| Regner KR, Harmon AC, Williams JM, Stelloh C, Johnson AC, Kyle PB, Lerch-Gaggl A, White SM, Garrett MR, Increased susceptibility to kidney injury by transfer of genomic segment from SHR onto Dahl S genetic background. Physiological genomics, 2012 Jun 15;44(12):629-37 | 2012 |
| Fernandez MM, Gonzalez D, Williams JM, Roman RJ, Nowicki S, Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine. European journal of pharmacology, 2012 Jul 5;686(1-3):97-103 | 2012 |
| Sawyer RT, Flynn ER, Hutchens ZM Jr, Williams JM, Garrett MR, Maric-Bilkan C, Renoprotective effects of C-peptide in the Dahl salt-sensitive rat. American journal of physiology. Renal physiology, 2012 Sep 15;303(6):F893-9 | 2012 |
| Williams JM, Johnson AC, Stelloh C, Dreisbach AW, Franceschini N, Regner KR, Townsend RR, Roman RJ, Garrett MR, Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat. Hypertension (Dallas, Tex. : 1979), 2012 Nov;60(5):1157-68 | 2012 |
| Williams JM, Burke M, Lazar J, Jacob HJ, Roman RJ, Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains. American journal of physiology. Renal physiology, 2011 Feb;300(2):F330-8 | 2011 |
| Williams JM, Zhang J, North P, Lacy S, Yakes M, Dahly-Vernon A, Roman RJ, Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. American journal of physiology. Renal physiology, 2011 Apr;300(4):F983-98 | 2011 |
| Moreno C, Williams JM, Lu L, Liang M, Lazar J, Jacob HJ, Cowley AW Jr, Roman RJ, Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains. American journal of physiology. Heart and circulatory physiology, 2011 Apr;300(4):H1530-5 | 2011 |
| Williams JM, Murphy S, Burke M, Roman RJ, 20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertension. Journal of cardiovascular pharmacology, 2010 Oct;56(4):336-44 | 2010 |
| Williams JM, Sarkis A, Hoagland KM, Fredrich K, Ryan RP, Moreno C, Lopez B, Lazar J, Fenoy FJ, Sharma M, Garrett MR, Jacob HJ, Roman RJ, Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. American journal of physiology. Renal physiology, 2008 Dec;295(6):F1764-77 | 2008 |
| Elmarakby AA, Williams JM, Imig JD, Pollock JS, Pollock DM, Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. Vascular pharmacology, 2007 Feb;46(2):144-51 | 2007 |
| Williams JM, Sarkis A, Lopez B, Ryan RP, Flasch AK, Roman RJ, Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis. Hypertension (Dallas, Tex. : 1979), 2007 Mar;49(3):687-94 | 2007 |
| Williams JM, Sharma M, Anjaiahh S, Falck JR, Roman RJ, Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier. American journal of physiology. Renal physiology, 2007 Aug;293(2):F501-5 | 2007 |
| Williams JM, Pollock DM, Contribution of prostanoid tp receptors to the pressor and intrarenal haemodynamic response to endothelin. Clinical and experimental pharmacology & physiology, 2006 Mar;33(3):253-7 | 2006 |
| Williams JM, Zhao X, Wang MH, Imig JD, Pollock DM, Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade. Hypertension (Dallas, Tex. : 1979), 2005 Aug;46(2):366-71 | 2005 |
| Williams JM, Pollock JS, Pollock DM, Arterial pressure response to the antioxidant tempol and ETB receptor blockade in rats on a high-salt diet. Hypertension (Dallas, Tex. : 1979), 2004 Nov;44(5):770-5 | 2004 |
| Elmarakby AA, Williams JM, Pollock DM, Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension. Current opinion in investigational drugs (London, England : 2000), 2003 Mar;4(3):282-90 | 2003 |
| Wingard CJ, Husain S, Williams J, James S, RhoA-Rho kinase mediates synergistic ET-1 and phenylephrine contraction of rat corpus cavernosum. American journal of physiology. Regulatory, integrative and comparative physiology, 2003 Nov;285(5):R1145-52 | 2003 |
| Murphy S, Williams JM, Impaired renal autoregulation in susceptible models of renal disease. Current vascular pharmacology, 2014;12(6):859-66 | |
| Fan F, Sun CW, Maier KG, Williams JM, Pabbidi MR, Didion SP, Falck JR, Zhuo J, Roman RJ, 20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels. PloS one, 2013;8(12):e82482 | |
Abstracts | |
| Denise C Cornelius, Olivia Travis, Dakota White, Cedar Baik, Willie Thompson, Chelsea Giachelli, Jan Michael Williams, Babbette LaMarca IL-17 Signaling Mediates Cytolytic Natural Killer Cell Activation in Response to Placental Ischemia AHA Hypertension Council 2019 Scientific Sessions | 2019 |
| Travis O, Baik C, Jackson C, Giachelli C, Williams JM, Cornelius DC Cytolytic Natural Killer Cells Play a Direct Role in Causing Hypertension and Intrauterine Growth Restriction in Pregnant Rats AHA Hypertension Council 2019 Scientific Sessions | 2019 |
| Cornelius DC, Travis O, White D, Baik C, Thompson W, Giachelli C, Williams JM Suppression of TH17 Cells Blunts Preeclampsia-Associated Cytolytic Natural Killer Cells during Pregnancy 2019 Experimental Biology, Orlando, FL | 2019 |
| Shields CA, Poudel B, Browning E, and Williams JM Effects of Gemfibrozil on the Progression of Proteinuria in Obese Dahl Salt-Sensitive Rats Volume 33, Issue 1_supplement01 Apr 2019, The FASEB Journal | 2019 |
| Poudel B, Shields CA, Pennington AP, Cornelius DC, and Williams JM Depletion of macrophages with clodronate partially reduces the progression renal injury in obese Dahl salt-sensitive rats during prepubertal obesity Volume 33, Issue 1_supplement01 Apr 2019, The FASEB Journal | 2019 |
| Pennington AP, Poudel B, Shields CA, Thompson WL, Williams JM Treatment with lisinopril slows the early progression of proteinuria in obese Dahl salt-sensitive rats independent of lowering arterial pressure and GFR Volume 33, Issue 1_supplement01 Apr 2019, The FASEB Journal | 2019 |
| Borges-Rodriguez M, Tramel R, Travis OK, Baik C, Greer M, Lemon JP, Williams JM, Cornelius DC Platelet Inhibition Prevents NLRP3 Inflammasome Activation and Sepsis-Induced Multi-Organ Injury 2019 Society of Critical Care Meeting, San Diego, CA | 2019 |
| Williams JM, McPherson KC, Shields CA, Poudel B, Cornelius DC, Garrett MR Early Renal Hyperfiltration in Obese Dahl Salt-Sensitive Leptin Receptor Mutant Rats is Associated with Glomerular Leukocyte Extravasation and Renal Disease 2018; Hypertension Volume 72, Issue Suppl_1 | 2018 |
| Travis O, White D, Pierce WA, Ge Y, Young C, Spradley F, Williams JM, Cornelius DC Interleukin-17 Mediates Hypertension, Intrauterine Growth Restriction, Cytolytic Natural Killer Cells and Vascular Dysfunction in Pregnant Rats AHA Hypertension Council 2018 | 2018 |
| Poudel B, Shields CA, Cornelius DC, and Williams JM Sex Differences in the Development of Renal Injury in Obese SSLepRmutant Rats during Prepubertal Obesity FASEB J. 2018 April; 32:906.5 | 2018 |
| Shields CA, Poudel B, McPherson KC, Garrett MR, and Williams JM Altered Immune Cell Programming in the Kidneys of Obese SSLepRmutant Rats Prior to Puberty FASEB J. 2018 April; 32:718.13 | 2018 |
| Wallace K, Szczepanski J, Spencer S, Williams JM, Jayaram A, and Novotny S Acute Kidney Injury in Pregnancy and HELLP Syndrome FASEB J. 2018 April; 32:LB347 | 2018 |
| 13. McPherson K, Pennington A, and Williams JM Treatment with Lisinopril Delays the Early Progression of Proteinuria in a Novel Model of Prepubertal Obesity | 2017 |
| McPherson K, Taylor L, Spires D, Johnson A, Guillory D, Garrett MR, and Williams JM. Decreased survival rate in female obese leptin receptor mutant Dahl salt-sensitive rats that develop chronic kidney disease. Hypertension Scientific Sessions 2015 | 2015 |
| McPherson K, Taylor L, Spires D, Szabo-Johnson A, and Williams JM. Evaluation of endothelin A receptor (ETA) blockade on the progression of renal injury in various models of metabolic disorders with pre-existing renal disease. Endothelin 14 Meeting 2015 | 2015 |
| McPherson K, Cornelius D, Thomas D, Taylor L, Spires D, Johnson A, Lamarca B, Garrett MR, and Williams JM. Early development of glomerular injury in Dahl salt-sensitive rats with metabolic syndrome independent of diabetes and hypertension. FASEB J April 2015 29:964.8 | 2015 |
| Taylor L, Fizer B, McPherson K, and Williams JM. The effects of atorvastatin on the progression of metabolic syndrome associated kidney disease. FASEB J April 2015 29:964.4 | 2015 |
| Spires D, Taylor L, McPherson K, and Williams JM. Effects of Endothelin-A Receptor and Angiotensin Converting Enzyme Inhibition on the Development of Progressive Proteinuria in Diabetic Dahl SS Rats with Pre-existing Renal Disease FASEB J April 2015 29:959.8 | 2015 |
| Murphy S, Wu W, White TN, Williams JM, Mayoux E, and Roman RJ Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy with hypertension Diabetes June 2014 63: Supplement 1 A217:850-P | 2014 |
| McPherson K, White TN, Johnson A, Geurts AM, Jacob HJ, Garrett MR and Williams JM Initial characterization of leptin receptor knockout Dahl salt-sensitive (SS) rats | 2014 |
| White TN, Spires D, Roman RJ and Williams JM Effects of hyperglycemia and cyclic stretching on MMP-2 and TGF-β in rat mesangial cells | 2014 |
| Spires D, White TN, Taylor L and Williams JM Contrasting differences of chronic endothelin A receptor (ETA) blockade during the progression of renal injury in type-1 and type-2 diabetic nephropathy | 2014 |
| Slaughter TN, Kojima N, Roman RJ and Williams JM Alterations in renal hemodynamics are associated with increased renal MMP-2 expression during the early phase of diabetic nephropathy Faseb J 27: 1183.2, 2013 | 2013 |
| Spires D, Slaughter TN, Taylor L and Williams JM Chronic ETA receptor blockade prevents the progression of renal injury in diabetic Dahl salt-sensitive (SS) rats Faseb J 27: 702.10, 2013 | 2013 |
| Gillis E, Mooney J, Roman RJ, Williams JM and Sasser JM Using the T2DN rat as a model to determine therapeutic efficacy of Serelaxin (recombinant human relaxin-2) for Diabetic Nephropathy Faseb J 27:LB889, 2013 | 2013 |
| Kojima N, Williams JM, Takahashi T, Miyata N and Roman RJ Renoprotective effects of SGLT2 inhibitor, Luseogliflozin, on the progression of diabetic nephropathy in T2DN rats Hypertension. 2012;60:A221 | 2012 |
| Slaughter TN, Paige A, Fan F, Kyle PB, Geurts AM, Howard JJ, Roman RJ and Williams JM Involvement of MMP-2 during the progression of renal disease in diabetic Dahl salt-sensitive rats Hypertension. 2012;60:A55 | 2012 |
| Williams JM, Slaughter TN, Paige A, Chen CC, Fan F, Geurts AM, Howard JJ, Roman RJ The role of MMP-2 during the development of hypertension-induced renal injury Dahl salt-sensitive rats Hypertension. 2012;60:A347 | 2012 |
| Slaughter TN, Paige A, Rucker C, Kyle PB, Kojima N, Garrett MR, Roman RJ and Williams JM Temporal characterization of the development diabetic-induced renal disease in strains of Goto-Kakizaki rats Hypertension. 2012;60:134 | 2012 |
| Williams JM, Slaughter TN, Wells A, Rucker C, Spires D, Kyle PB and Roman RJ Increased MMP-9 activity during the progression of renal injury in Type-2 Diabetic Nephropathy rats Faseb J 26: 687.4, 2012 | 2012 |
| Slaughter TN, Spires D, Rucker C, Wells A, Kyle PB, Roman RJ and Williams JM The reduction of renal injury in diabetic Dahl salt-sensitive rats with insulin is associated with decreased MMP activity Faseb J 26: 687.3, 2012 | 2012 |
| Williams JM, Wells A, Spires D. The progression of diabetes-induced renal injury in Dahl salt-sensitive rats Faseb J 25: 664.7, 2011 | 2011 |
Book Chapter | |
| Williams JM, Poudel B, Shields CA. Sex Differences in Autoimmune Type-1 Diabetes. In: Sex Differences in Cardiovascular Physiology and Pathophysiology. | 2019 |
| Williams JM and Pollock DM. Renal Endothelin In: Handbook of Biologically Active Peptides A.J. Kastin, Editgor, Elsevier, San Diego, 2006 | 2006 |
Presentations
| National and International Invited Seminars/Lectures, Sex differences in renal injury in a rat model of prepubertal obesity, APS, Knoxville, TN | 10/2018 |
| Regional Invited Seminars/Lectures, Using animal models to explore mechanisms involved in the development of renal disease associated with obesity, Fort Worth, TX | 08/2018 |
| State/Local Invited Seminars/Lectures, Using animal models to explore mechanisms involved in the development of renal disease associated with obesity, Jackson, MS | 02/2018 |
| National and International Invited Seminars/Lectures, Discovering mechanisms involved in the development of renal injury associated with prepubertal obesity, Renal Hemodynamics and Cardiovascular Function in Health and Disease, FASEB, Big Sky, MT | 06/2016 |
| Invited Symposia, Involvement of MMPs in the progression of diabetic nephropathy, FASEB Summer Conference, Saxtons River, VT | 07/2013 |
| Poster Presentation, The role of MMP-2 during the development of hypertension-induced renal injury Dahl salt-sensitive rats, High Blood Pressure Council Meeting, Wasington, D.C. | 09/2012 |
| Invited Symposia, Involvement of MMP-2 during the progression of renal disease in diabetic Dahl salt-sensitive rats, High Blood Pressure Council Meeting, Washington, D.C. | 09/2012 |
| Poster Presentation, Temporal characterization of the development diabetic-induced renal disease in strains of Goto-Kakizaki rats, High Blood Pressure Council Meeting, Washington, D.C. | 09/2012 |
| State/Local Invited Seminars/Lectures, Using genetic rodent models to study diabetic nephropathy, Augusta, GA | 06/2012 |
Honors, Awards, and Recognition
| Excellence in Research Award at the University of Mississippi Medical Center, UMMC | 2016 |
| Excellence Research Award, University of Mississippi Medical Center | 2014 |
| Fellow of the American Heart Association, American Heart Association | 2012 |
| Outstanding Poster Award, 12th Winter Eicosanoid Conference 2010 | 2010 |
| FASEB Young Investigator Award, FASEB Summer Conference 2007 | 2007 |
| UNCF Merck Postdoctoral Fellowship Award, UNCF-Merck Foundation | 2006 |
| The American Physiological Society Minority Travel Fellowship Award, Experimental Biology 2005 | 2005 |
| Forest Pharmaceutical New Investigator Travel Award, Cardiovascular-Renal Meeting 2008 | |
| Kidney Council New Investigator Award, High Blood Pressure Research Conference 2008 | |
| Who's Who Among Students in American College and Universities | |
| Award of Excellence in Physiology, Graduate Research Day 2004 | |
| Award of Excellence in Physiology, Medical College of Georgia, Graduate Reserach Day 2004 | |
| American Physiological Society Water and Electrolyte Award, Experimental Biology 2003 | |
| The American Physiological society Minority Travel Fellowship Award, Experimental Biology 2003 | |
| The American Physiological "Society Minority Travel "Fellowship Award, Experimental Biology 2002 |
Professional Membership and Service
| American Heart Association, Member | 2006 - Present |
| American Physiological Society, Member, Water and Electrolyte | 2004 - Present |
Committee Service
| Department of Pharmacology Admissions and Curriculum Committee, Chair | 2019 - Present |
| Department of Pharmacology Promotion and Tenure Committee, Vice Chair | 2017 - Present |
| AHA Vascular Endothelial Biology – Clinical Peer Review Committee, Chair | 2017 - Present |
| Medical Student Research Program Committee, Member | 2016 - Present |
| American Physiological Society Porter Physiology Development & Minority Committee, Member | 2016 - Present |
| AHA Vascular Endothelial Biology – Clinical Peer Review Committee, Member | 2015 - 2016 |
| Department of Pharmacology Graduate Admissions and Curriculum Committee, Member | 2013 - 2019 |
| American Heart Association Cardiorenal 3 Peer Review Committee, Member | 2013 - 2015 |
| UMMC Graduate School Alumni Committee, Member | 2012 - 2015 |
| American Physiological Society Awards Committee, Member | 2011 - 2014 |
Community Service
| Wolfpack Youth Basketball Program, Organizer and Mentor | 2013 - Present |
Other Service
| PLOS ONE Journal | 07/2016 - Present |
| AJP Renal Physiology | 07/2015 - Present |
| SURE Program, Mentor | 06/2015 - Present |
| AJP Regulatory Integrative Comparative Physiology | 07/2011 - Present |
| Journal of Hypertension | 07/2011 - Present |
| Base Pair Program, Mentor | 2010 - Present |
| Hypertension | 07/2009 - Present |
Teaching Experience
| Graduate, Course, Lecturer, Fundamental Pharmacology | Spring 2019 |
| Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2019 |
| Graduate, Course, Lecturer, Experimental Design and Methods | Spring 2019 |
| Graduate, Course, Lecturer, Fundamental Pharmacology | Spring 2018 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2018 |
| Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2018 |
| Graduate, Course, Lecturer, Experimental Design and Methods | Spring 2018 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2017 |
| Graduate, Course, Lecturer, Mechanisms of Drug Actions | Spring 2017 |
| PHARM 726, Graduate, Course, Lecturer, Fundamental Pharmacology | Spring 2017 |
| PHARM 724, Graduate, Course, Lecturer, Experimental Design and Methods | Spring 2017 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2016 |
| Dentistry, Course, Lecturer, Dental Pharmacology | Spring 2016 |
| Graduate, Course, Lecturer, Mechanisms of Drug Actions | Spring 2016 |
| Dentistry, Lecture, Lecturer, Dental Pharmacology | Spring 2015 |
| Graduate, Lecture, Lecturer, Mechanism of Drug Action | Spring 2015 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2015 |
| Dentistry, Lecture, Lecturer, Dental Pharmacology | Spring 2014 - 2014 |
| Graduate, Lecture, Lecturer, Mechanisms of Drug Action | Spring 2014 - 2014 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2014 |
| Graduate, Lecture, Lecturer, Mechanisms of Drug Action | Spring 2013 - 2013 |
| Dentistry, Lecture, Lecturer, Dental Pharmacology | Spring 2013 - 2013 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2013 |
| Dentistry, Course, Assistant Course Director, Dental Pharmacology | Annual 2013 |
Directed Student Learning
| Dissertation Committee Chair, The role of macrophages in the progression of renal injury associated with obesity Advised: Bibek Poudel | 2018 - Present |
| Dissertation Committee Chair, Effects of glomerular hyperfiltration on lipid accumulation during the progression renal injury associated with obesity Advised: Corbin Shields | 2018 - Present |
| Research Advisor, Effects of lisinopril on the development of renal injury associated with obesity Advised: Alyssa Pennington | 2016 - 2019 |
| Research Advisor, Role of dyslipidemia in chronic kidney disease Advised: Brianca Fizer | 2014 - 2014 |
| Research Advisor, Effects of statin therapy on the development of diabetic nephropathy Advised: Destenee Green | 2014 - 2014 |
| Dissertation Defense Committee Chair, Evaluating temporal changes in renal hemodynamics during obesity related kidney disease Advised: Kasi McPherson | 2013 - 2017 |
| Research Advisor, Inflammation during diabetic nephropathy Advised: Judson Womack | 2013 - 2014 |
| Research Advisor, Role of TNF-alpha in the development of diabetic kidney disease Advised: Alyssa Pennington | 2013 - 2014 |
| Research Advisor, Effects endothelin receptor A blockade on the progression diabetes-induced renal disease Advised: Denisha Spires | 2012 - 2015 |
| Research Advisor, Inhibition of MMP activity on kidney disease associated with diabetes Advised: Carlos Rucker | 2012 - 2013 |
| Dissertation Defense Committee Chair, Role of MMP-2 in the Progression of Diabetes-inudced Renal Disease Advised: Tiffani White | 2011 - 2014 |
| Research Advisor, The effects of high fat diet on the development of renal disease in diabetic Dahl salt-sensitive rats Advised: Denisha Spires | 2010 - 2011 |