Donald B. Sittman

Donald B. Sittman

PROFESSOR EMERITUS

Department:
SOM-Cell and Molecular Biology

Education

University of North Carolina Chapel Hill, PhD, Zoology/Molecular Biology1978
University of North Carolina Chapel Hill, BA, Zoology1971

Current Positions

Chair, School of Medicine, Department of Biochemistry07/2010 - Present
Director, Department of Biochemistry2000 - Present
Professor, School of Medicine, Department of Biochemistry1997 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Interim Chair, UMMC, School of Medicine, Department of Biochemistry2006 - 2010
Associate Professor, UMMC, School of Medicine, Department of Biochemistry1988 - 1997
Assistant Professor, UMMC, School of Medicine, Department of Biochemistry1982 - 1988
Postdoctoral Fellow, Florida State University, Department of Chemistry1978 - 1982

Sponsored Program Funding

Extramural, Mississippi Functional Genomics Network, NIH09/2010 - 05/2013
Extramural, Mississippi Functional Genomics Network, NIH06/2004 - 05/2009

Publications

Journal Article

Bhan S, May W, Warren S, and Sittman, DB Global Gene Expression Analysis Reveals Specific and Redundant Roles for H1 Variants, H1c and H10, in Gene Expression Regulation. Gene 2008; 414:10-18.2008
Wellman SEE, Casano PJ, Pilch RR, Marzluff WF, Sittman DB Characterization of mouse H3.3-like histone genes Gene 1987: 59:29-39
Gunjan A, Sittman DB, Brown DT Core histone acetylation is regulated by linker histone stoichiometry in vivo J. Biol. Chem. 2001: 276:3635-3640
Gunjan A, Sittman DB, Brown DT Core histone acetylation is regulated by linker histone stoichiometry in vivo J. Biol. Chem.2001: 276:3635-3640
Brown DT, Alexander BT, Sittman DB Differential effect of H1 variant overexpression on cell cycle progression and gene expression Nucleic Acids Res. 1996: 24:486-493
Brown DT, Gun jan A, Alexander BT, Sittman DB Differential effect of H1 variant overproduction on gene expression is due to differences in the central globular domain
Sittman DB DNA Fingerprint Analysis: State of the Art Identification J. MS Acad. Sci. 1991: 36: 8-10
Gunjan A, Alexander BT, Sittman DB, Brown DT Effects of H1 histone variant over-expression on chromatin structure J. Biol. Chem. 1999: 274:37950-37956
Majji S, Thodima V, Arnizaut A, Deng Y, May W, Sittman D, Waldbieser GC, Hanson L, Cuchens MA, Bengten E, Chinchar VG Expression profiles of cloned channel catfish (Ictalurus punctatus) lymphoid cell lines and mixed lymphocyte cultures Dev. & Comp. Immunology 2009 33:224-234
Bhan S, May W, Warren S, Sittman Global Gene Expression Analysis Reveals Specific and Redundant Roles for H1 Variants, H1c and H10, in Gene Expression Regulation Gene 2008: 414:10-18
Brown DT, Yang Y-S, Sittman DB Histone gene switching in murine erythroleukemia cells is differentiation specific and occurs without loss of cell cycle regulation Mol. Cell. Biol. 1988: 8:4406-4415
Lu zH, Sittman DB, Brown DT, Munshi R, Leno GH Histone H1 modulates DNA replication through multiple pathways in Xenopus egg extract. J. Cell. Sci. 1997: 110:2745-2758
LLu ZH, Sittman DB, Romanowski P, Leno GH Histone H1 reduces the frequency of initiation in Xenopus egg extract by limiting the assembly of prereplication complexes on sperm chromatin Mol. Biol. Cell 1998: 9:1163-1176
Lu ZH, Sittman DB, Romanowski P, Leno GH Histone H1 reduces the frequency of initiation in Xenopus egg extract by limiting the assembly of prereplication complexes on sperm chromatin Mol. Biol. Cell 1998: 9:1163-1176
De S, Lu ZH, Wellman SE, Leno GH, Brown DT, Sittman DB Histone H1 variants differentially inhibit DNA replication through an affinity for chromatin mediated by their carboxyl-terminal domains Gene 2002: 292:173-181
Sittman DB, Graves RA, Marzluff WF Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation Proc. Natl. Acad. Sci. USA 1983: 80:1849-1852
Brown DT, Sittman DB Identification through overexpression and tagging of the variant type of the mouse H1e and H1c genes J. Biol. Chem. 1993: 268:713-718
Yabg T-S, Brown DT, Wellman SE, Sittman DB Isolation and characterization of a mouse fully replication-dependent H1 gene within a cluster of core histone genes J. Biol. Chem. 1987: 262:17118-17125
Dong Y, Sirotkin AM, Yang Y-S, Brown DT, Sittman DB, Skoultchi AI Isolation and characteriza¬tion of two replication-dependent mouse H1 histone genes Nucleic Acids Res. 1994: 22:1421-1428
Sittman DB, Chiu I-M, Pan C-J, Cohn RH, Kedes LH, Marzluff WF Isolation of two clusters of mouse histone genes Proc. Natl. Acad. Sci. USA 1981: 78:4078-4082
Christopher CS, Sittman DB, Stafford DW Phenylalanine Transfer Ribonucleic Acid Synthetase from Drosophila melanogaster Arch. Biochem. Biophys. 1975: 166: 94-101
Wellman SE, Sittman DB, Chaires JB Preferential binding of H1e histone to GC-rich DNA Biochemistry 1994: 33:384-388
Sittman DB, Stafford DW Purification and Characterization of the RNA Polymerases of the Sea Urchin Lytechinus variegatus Preparative Biochem. 1983: 13: 21-29
Sittman DB, Graves aRA, Marzluff WF Structure of a cluster of mouse histone genes Nucleic Acids Res. 1983: 11:6679-6697
Daum HA, Bragg PW, Sittman DB, Dholakia JN, Woodley CW, Wahba AJ The expression of a gene for eukaryotic elongation factor Tu in Artemia during development. Translation of Poly(A)+RNA and the use of a synthetic oligonucleotide to detect the presence of eukaryotic elongation factor Tu-specific mRNA J. Biol. Chem. 1985: 260:16347-53

Book

Davidson VL, Sittman DB Biochemistry, 3rd Ed. National Medical Series Harwal Publishing Co., Malvern, PA., 1993
Davidson VL, Sittman DB Biochemistry, 4th Ed. National Medical Series Williams & Wilkins., Malvern, PA. , 1999

Honors, Awards, and Recognition

D1 Basic Science Professor of the Year, Hembree Society2009
Excellence in Research Award Gold Level, Office of Research UMC2007
Nelson Order2007
Excellence in Research Award Silver Level, Office of Research UMC2005
Excellence in Classroom Instruction (in Dental Biochemistry), Students of UMC School Of Dentistry1998
Excellence in Classroom Instruction, Students of UMC School of Dentistry1996

Committee Service

School Of Dentistry - Executive, Member2006 - Present
School Of Graduate Studies - Graduate Council, Member2006 - Present
School Of Medicine - Executive Faculty, Member2006 - Present
School Of Dentistry - Curriculum, Member

Directed Student Learning

Doctoral Advisory Committee Chair, Global gene expression analysis reveals specific and redundant roles for H1 variants, H1c and H1-0, in gene expression regulation
Advised: Sheetal Bhan