Jawed A. Siddiqui, PhD

Jawed A. Siddiqui, PhD

Assistant Professor

Department:
SOM-Cell and Molecular Biology

Email:
jsiddiqui@umc.edu

Work Phone:
(601) 984-4309

Biography

One of the major objectives of our laboratory is to elucidate biological mechanisms underlying bone metastasis of different malignancies. Bone metastases or dissemination of cancer cells within the bone are considered an advanced, debilitating, and incurable disease. Despite its high morbidity and mortality, the biology of bone metastasis signifies one of the most multifaceted and fascinating processes in several malignancies. Prostate, breast, lung, and kidney cancers have characteristics of selective bone tropism.
The convolution of bone metastases derives from the intricately organized bone microenvironment where numerous vital processes, including hematopoiesis, osteogenesis, and osteolysis, are conjointly regulated with spatial limitations. Dissemination and homing of tumor cells in the bone microenvironment are uniquely primed to destabilize the homeostasis of the bone microenvironment and fuel the pathological osteolytic and osteoblastic lesions. The bone metastasis process can be separated into three key steps (seeding, dormancy, and outgrowth), and targeting dormancy and outgrowth in bone microenvironments offers the most therapeutic promise.
Our lab has developed unique techniques and experimental models that allow us to decipher bone metastasis. Metastatic tumors attain the skill to blunt or overturn the functions of the immune system. We are interested in dissecting how metastatic cancers evolve to persuade the immune system's dysfunctionality in primary and metastatic sites among tumors of diverse genetic backgrounds. Unraveling the mechanisms of the immune system and bone cell cross-talk offers therapeutic possibilities for bone metastasis. We study how cancer cells influence bone resident macrophages (Osteomacs) for their colonization and growth within the bone microenvironment and design therapeutic strategies accordingly.
Current projects in the lab include:
1. Molecular mechanism of bone metastasis (Prostate, Breast, and Lung cancer)
2. Bone Microenvironment
3. Osteoimmunology and Tumor Dormancy.
4. Development of the Bone metastasis Therapeutics
Research Opportunities:
If you are excited about contributing to bone metastasis research, join our collaborative team. We always look for a highly enthusiastic researcher to join as graduate students, summer fellows, clinical fellows, and postdoctoral fellows. We are continuously open to collaboration.

Education

Central Drug Research Institute/JNU, India, PhD, Endocrinology and Bone Biology

Academic Appointments or Other Previous Appointments

Assistant Professor, University of Nebraska Medical Center, School of Medicine

Sponsored Program Funding

Intramural, Targeting Mitochondrial metabolism to overcome enzalutamide resistance in Prostate cancer bone metastasis, 05. American Cancer Society (ACS)02/2024 - 02/2025
Extramural, Therapeutic Targeting of GFRAL/RET Axis to Overcome Bone Metastasis of Breast Cancer, METAvivor09/2022 - 07/2025
Intramural, Targeting Aryl Hydrocarbon Receptor, a Novel Immunotherapeutic Approach for Lung Cancer-Bone Metastasis, Fred and Pamela Buffett Cancer (FPBCC)02/2022 - 02/2024
Extramural, Targeting Novel GDF15/GFRAL/RET Axis in Prostate Cancer Bone Metastasis, DoD07/2021 - 07/2025
Extramural, Targeting MUC5AC Mucin in breast cancer brain metastasis, NCI02/2021 - 01/2026

Publications

Journal Article

Raza S, Siddiqui JA, Srivastava A, Chattopadhyay N, Sinha RA, Chakravarti B, Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective. Autophagy reports, 2024 Dec 31;3(1)2024
Kaushal JB, Raut P, Muniyan S, Siddiqui JA, Alsafwani ZW, Seshacharyulu P, Nair SS, Tewari AK, Batra SK, Racial disparity in prostate cancer: an outlook in genetic and molecular landscape. Cancer metastasis reviews, 2024 Dec;43(4):1233-12552024
Chaudhary S, Siddiqui JA, Appadurai MI, Maurya SK, Murakonda SP, Blowers E, Swanson BJ, Nasser MW, Batra SK, Lakshmanan I, Ganti AK, Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma. Experimental & molecular medicine, 2024 Jun;56(6):1450-14602024
Kaushal JB, Takkar S, Batra SK, Siddiqui JA, Diverse landscape of genetically engineered mouse models: Genomic and molecular insights into prostate cancer. Cancer letters, 2024 Jul 1;593:2169542024
Takkar S, Sharma G, Kaushal JB, Abdullah KM, Batra SK, Siddiqui JA, From orphan to oncogene: The role of GPR35 in cancer and immune modulation. Cytokine & growth factor reviews, 2024 Jun;77:56-662024
Abdullah KM, Sharma G, Qais FA, Khan I, Takkar S, Kaushal JB, Kanchan RK, Sarwar T, Chakravarti B, Siddiqui JA, Hydroxychloroquine interaction with phosphoinositide 3-kinase modulates prostate cancer growth in bone microenvironment: In vitro and molecular dynamics based approach. International journal of biological macromolecules, 2024 May;266(Pt 1):1309122024
Abdullah KM, Kaushal JB, Takkar S, Sharma G, Alsafwani ZW, Pothuraju R, Batra SK, Siddiqui JA, Copper metabolism and cuproptosis in human malignancies: Unraveling the complex interplay for therapeutic insights. Heliyon, 2024 Mar 15;10(5):e274962024
Abdullah KM, Sharma G, Takkar S, Kaushal JB, Pothuraju R, Chakravarti B, Batra SK, Siddiqui JA, α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation. Scientific reports, 2024 Feb 22;14(1):44042024
Malakar P, Shukla S, Mondal M, Kar RK, Siddiqui JA, The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations. RNA biology, 2024 Jan;21(1):1-202024
Sharma G, Sultana A, Abdullah KM, Pothuraju R, Nasser MW, Batra SK, Siddiqui JA, Epigenetic regulation of bone remodeling and bone metastasis. Seminars in cell & developmental biology, 2024 Feb 15;154(Pt C):275-2852024
Maurya SK, Rehman AU, Zaidi MAA, Khan P, Gautam SK, Santamaria-Barria JA, Siddiqui JA, Batra SK, Nasser MW, Epigenetic alterations fuel brain metastasis via regulating inflammatory cascade. Seminars in cell & developmental biology, 2024 Feb 15;154(Pt C):261-2742024
Barkeer S, Pothuraju R, Malakar P, Pimentel TC, Siddiqui JA, Nair SA, Gum acacia dietary fiber: Significance in immunomodulation, inflammatory diseases, and cancer. Phytotherapy research : PTR, 2024 Mar;38(3):1509-15212024
Sharma G, Abdullah KM, Qais FA, Khan P, Cox JL, Sarwar T, Nasser MW, Batra SK, Siddiqui JA, Clofazimine inhibits small-cell lung cancer progression by modulating the kynurenine/aryl hydrocarbon receptor axis. International journal of biological macromolecules, 2024 Dec;282(Pt 3):1369212024
Chakravarti B, Rajput S, Srivastava A, Sharma LK, Sinha RA, Chattopadhyay N, Siddiqui JA, A Systematic Review and Meta-Analysis of the Effects of Dietary Isoflavones on Female Hormone-Dependent Cancers for Benefit-Risk Evaluation. Phytotherapy research : PTR, 2024 Dec;38(12):6062-60812024
Malik JR, Podany AT, Khan P, Shaffer CL, Siddiqui JA, Baranowska-Kortylewicz J, Le J, Fletcher CV, Ether SA, Avedissian SN, Chemotherapy in pediatric brain tumor and the challenge of the blood-brain barrier. Cancer medicine, 2023 Dec;12(23):21075-210962023
Khan P, Siddiqui JA, Kshirsagar PG, Venkata RC, Maurya SK, Mirzapoiazova T, Perumal N, Chaudhary S, Kanchan RK, Fatima M, Khan MA, Rehman AU, Lakshmanan I, Mahapatra S, Talmon GA, Kulkarni P, Ganti AK, Jain M, Salgia R, Batra SK, Nasser MW, MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis. Molecular cancer, 2023 Jan 4;22(1):12023
Benjamin M, Malakar P, Sinha RA, Nasser MW, Batra SK, Siddiqui JA, Chakravarti B, Molecular signaling network and therapeutic developments in breast cancer brain metastasis. Advances in cancer biology - metastasis, 2023 Jul;7:1000792023
Bhatia R, Siddiqui JA, Ganguly K, Thompson CM, Cannon A, Aithal A, Perumal N, Maurya SK, Li X, Cox JL, Gurumurthy CB, Rachagani S, Jain M, Nasser MW, Batra SK, Kumar S, Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis. Oncogene, 2023 Mar;42(10):759-7702023
Chakravarti B, Akhtar Siddiqui J, Anthony Sinha R, Raza S, Targeting autophagy and lipid metabolism in cancer stem cells. Biochemical pharmacology, 2023 Jun;212:1155502023
Lakshmanan I, Marimuthu S, Chaudhary S, Seshacharyulu P, Rachagani S, Muniyan S, Chirravuri-Venkata R, Atri P, Rauth S, Nimmakayala RK, Siddiqui JA, Gautam SK, Shah A, Natarajan G, Parte S, Bhyravbhatla N, Mallya K, Haridas D, Talmon GA, Smith LM, Kumar S, Ganti AK, Jain M, Ponnusamy MP, Batra SK, Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma. Oncogene, 2022 Nov;41(48):5147-51592022
Bhatia R, Thompson CM, Clement EJ, Ganguly K, Cox JL, Rauth S, Siddiqui JA, Mashiana SS, Jain M, Wyatt TA, Mashiana HS, Singh S, Woods NT, Kharbanda KK, Batra SK, Kumar S, Malondialdehyde-Acetaldehyde Extracellular Matrix Protein Adducts Attenuate Unfolded Protein Response During Alcohol and Smoking-Induced Pancreatitis. Gastroenterology, 2022 Oct;163(4):1064-1078.e102022
Rehman AU, Khan P, Maurya SK, Siddiqui JA, Santamaria-Barria JA, Batra SK, Nasser MW, Liquid biopsies to occult brain metastasis. Molecular cancer, 2022 May 10;21(1):1132022
Pothuraju R, Pai P, Chaudhary S, Siddiqui JA, Cox JL, Kaur S, Rachagani S, Roy HK, Bouvet M, Batra SK, Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer. Aging, 2022 Mar 7;14(5):2025-20462022
Mughees M, Kaushal JB, Sharma G, Wajid S, Batra SK, Siddiqui JA, Chemokines and cytokines: Axis and allies in prostate cancer pathogenesis. Seminars in cancer biology, 2022 Nov;86(Pt 3):497-5122022
Sharma G, Pothuraju R, Kanchan RK, Batra SK, Siddiqui JA, Chemokines network in bone metastasis: Vital regulators of seeding and soiling. Seminars in cancer biology, 2022 Nov;86(Pt 3):457-4722022
Siddiqui JA, Seshacharyulu P, Muniyan S, Pothuraju R, Khan P, Vengoji R, Chaudhary S, Maurya SK, Lele SM, Jain M, Datta K, Nasser MW, Batra SK, GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation. Bone research, 2022 Jan 20;10(1):62022
Siddiqui JA, Pothuraju R, Khan P, Sharma G, Muniyan S, Seshacharyulu P, Jain M, Nasser MW, Batra SK, Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia. Cytokine & growth factor reviews, 2022 Apr;64:71-832022
Khan P, Ebenezer NS, Siddiqui JA, Maurya SK, Lakshmanan I, Salgia R, Batra SK, Nasser MW, MicroRNA-1: Diverse role of a small player in multiple cancers. Seminars in cell & developmental biology, 2022 Apr;124:114-1262022
Khan P, Siddiqui JA, Maurya SK, Lakshmanan I, Jain M, Ganti AK, Salgia R, Batra SK, Nasser MW, Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease. Seminars in cancer biology, 2022 Aug;83:57-762022
Chaudhary S, Pothuraju R, Rachagani S, Siddiqui JA, Atri P, Mallya K, Nasser MW, Sayed Z, Lyden ER, Smith L, Gupta SD, Ralhan R, Lakshmanan I, Jones DT, Ganti AK, Macha MA, Batra SK, Dual blockade of EGFR and CDK4/6 delays head and neck squamous cell carcinoma progression by inducing metabolic rewiring. Cancer letters, 2021 Jul 10;510:79-922021
Khan P, Siddiqui JA, Lakshmanan I, Ganti AK, Salgia R, Jain M, Batra SK, Nasser MW, RNA-based therapies: A cog in the wheel of lung cancer defense. Molecular cancer, 2021 Mar 19;20(1):542021
Siddiqui JA, Le Henaff C, Johnson J, He Z, Rifkin DB, Partridge NC, Osteoblastic monocyte chemoattractant protein-1 (MCP-1) mediation of parathyroid hormone's anabolic actions in bone implicates TGF-β signaling. Bone, 2021 Feb;143:1157622021
Gautam SK, Kanchan RK, Siddiqui JA, Maurya SK, Rauth S, Perumal N, Atri P, Venkata RC, Mallya K, Mirza S, Ponnusamy MP, Band V, Mahapatra S, Jain M, Batra SK, Nasser MW, Blocking c-MET/ERBB1 Axis Prevents Brain Metastasis in ERBB2+ Breast Cancer. Cancers, 2020 Oct 1;12(10)2020
Muniyan S, Rachagani S, Parte S, Halder S, Seshacharyulu P, Kshirsagar P, Siddiqui JA, Vengoji R, Rauth S, Islam R, Mallya K, Datta K, Xi L, Das A, Teply BA, Kukreja RC, Batra SK, Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling. Clinical cancer research : an official journal of the American Association for Cancer Research, 2020 Nov 1;26(21):5720-57342020
Siddiqui JA, Pothuraju R, Jain M, Batra SK, Nasser MW, Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions. Biochimica et biophysica acta. Reviews on cancer, 2020 Apr;1873(2):1883592020
Pothuraju R, Rachagani S, Krishn SR, Chaudhary S, Nimmakayala RK, Siddiqui JA, Ganguly K, Lakshmanan I, Cox JL, Mallya K, Kaur S, Batra SK, Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance. Molecular cancer, 2020 Feb 25;19(1):372020
Kanchan RK, Siddiqui JA, Mahapatra S, Batra SK, Nasser MW, microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy. Molecular cancer, 2020 Feb 15;19(1):292020
Vengoji R, Macha MA, Nimmakayala RK, Rachagani S, Siddiqui JA, Mallya K, Gorantla S, Jain M, Ponnusamy MP, Batra SK, Shonka N, Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells. Journal of experimental & clinical cancer research : CR, 2019 Jun 18;38(1):2662019
Seshacharyulu P, Rachagani S, Muniyan S, Siddiqui JA, Cruz E, Sharma S, Krishnan R, Killips BJ, Sheinin Y, Lele SM, Smith LM, Talmon GA, Ponnusamy MP, Datta K, Batra SK, FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis. Oncogene, 2019 Jun;38(26):5265-52802019
Qazi AK, Siddiqui JA, Jahan R, Chaudhary S, Walker LA, Sayed Z, Jones DT, Batra SK, Macha MA, Emerging therapeutic potential of graviola and its constituents in cancers. Carcinogenesis, 2018 Apr 5;39(4):522-5332018
Siddiqui JA, Johnson J, Le Henaff C, Bitel CL, Tamasi JA, Partridge NC, Catabolic Effects of Human PTH (1-34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism. Scientific reports, 2017 Nov 10;7(1):153002017
Siddiqui JA, Partridge NC, Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement. Physiology (Bethesda, Md.), 2016 May;31(3):233-452016
Bandyopadhyay GK, Lu M, Avolio E, Siddiqui JA, Gayen JR, Wollam J, Vu CU, Chi NW, O'Connor DT, Mahata SK, Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance. Diabetes, 2015 Jan;64(1):104-162015
Vu CU, Siddiqui JA, Wadensweiler P, Gayen JR, Avolio E, Bandyopadhyay GK, Biswas N, Chi NW, O'Connor DT, Mahata SK, Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. Endocrinology, 2014 Oct;155(10):3793-8052014
Dev NB, Mir SA, Gayen JR, Siddiqui JA, Mustapic M, Vaingankar SM, Cardiac electrical activity in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension. Journal of cardiovascular translational research, 2014 Jul;7(5):483-4932014
Chakravarti B, Akhtar T, Rai B, Yadav M, Akhtar Siddiqui J, Dhar Dwivedi SK, Thakur R, Singh AK, Singh AK, Kumar H, Khan K, Pal S, Rath SK, Lal J, Konwar R, Trivedi AK, Datta D, Mishra DP, Godbole MM, Sanyal S, Chattopadhyay N, Kumar A, Thioaryl naphthylmethanone oxime ether analogs as novel anticancer agents. Journal of medicinal chemistry, 2014 Oct 9;57(19):8010-252014
Swarnkar G, Sharan K, Siddiqui JA, Mishra JS, Khan K, Khan MP, Gupta V, Rawat P, Maurya R, Dwivedi AK, Sanyal S, Chattopadhyay N, A naturally occurring naringenin derivative exerts potent bone anabolic effects by mimicking oestrogen action on osteoblasts. British journal of pharmacology, 2012 Mar;165(5):1526-422012
Dixit P, Chand K, Khan MP, Siddiqui JA, Tewari D, Ngueguim FT, Chattopadhyay N, Maurya R, Phytoceramides and acylated phytosterol glucosides from Pterospermum acerifolium Willd. seed coat and their osteogenic activity. Phytochemistry, 2012 Sep;81:117-252012
Chakravarti B, Maurya R, Siddiqui JA, Bid HK, Rajendran SM, Yadav PP, Konwar R, In vitro anti-breast cancer activity of ethanolic extract of Wrightia tomentosa: role of pro-apoptotic effects of oleanolic acid and urosolic acid. Journal of ethnopharmacology, 2012 Jun 26;142(1):72-92012
Ngueguim FT, Khan MP, Donfack JH, Siddiqui JA, Tewari D, Nagar GK, Tiwari SC, Theophile D, Maurya R, Chattopadhyay N, Evaluation of Cameroonian plants towards experimental bone regeneration. Journal of ethnopharmacology, 2012 May 7;141(1):331-72012
Balaramnavar VM, Khan IA, Siddiqui JA, Khan MP, Chakravarti B, Sharan K, Swarnkar G, Rastogi N, Siddiqui HH, Mishra DP, Chattopadhyay N, Saxena AK, Identification of novel 2-((1-(benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)benzoic acid analogues as BMP-2 stimulators. Journal of medicinal chemistry, 2012 Oct 11;55(19):8248-592012
Swarnkar G, Sharan K, Siddiqui JA, Chakravarti B, Rawat P, Kumar M, Arya KR, Maurya R, Chattopadhyay N, A novel flavonoid isolated from the steam-bark of Ulmus wallichiana planchon stimulates osteoblast function and inhibits osteoclast and adipocyte differentiation. European journal of pharmacology, 2011 May 11;658(2-3):65-732011
Chakravarti B, Siddiqui JA, Dwivedi SK, Deshpande S, Samanta K, Bhatta RS, Panda G, Prabhakar YS, Konwar R, Sanyal S, Chattopadhyay N, Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative. Molecular and cellular endocrinology, 2011 May 16;338(1-2):68-782011
Siddiqui JA, Sharan K, Swarnkar G, Rawat P, Kumar M, Manickavasagam L, Maurya R, Pierroz D, Chattopadhyay N, Quercetin-6-C-β-D-glucopyranoside isolated from Ulmus wallichiana planchon is more potent than quercetin in inhibiting osteoclastogenesis and mitigating ovariectomy-induced bone loss in rats. Menopause (New York, N.Y.), 2011 Feb;18(2):198-2072011
Siddiqui JA, Swarnkar G, Sharan K, Chakravarti B, Gautam AK, Rawat P, Kumar M, Gupta V, Manickavasagam L, Dwivedi AK, Maurya R, Chattopadhyay N, A naturally occurring rare analog of quercetin promotes peak bone mass achievement and exerts anabolic effect on osteoporotic bone. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011 Dec;22(12):3013-272011
Kumar A, Tripathi VD, Kumar P, Gupta LP, Akanksha, Trivedi R, Bid H, Nayak VL, Siddiqui JA, Chakravarti B, Saxena R, Dwivedi A, Siddiquee MI, Siddiqui U, Konwar R, Chattopadhyay N, Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents. Bioorganic & medicinal chemistry, 2011 Sep 15;19(18):5409-192011
Sharan K, Mishra JS, Swarnkar G, Siddiqui JA, Khan K, Kumari R, Rawat P, Maurya R, Sanyal S, Chattopadhyay N, A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011 Sep;26(9):2096-1112011
Sharan K, Siddiqui JA, Swarnkar G, Tyagi AM, Kumar A, Rawat P, Kumar M, Nagar GK, Arya KR, Manickavasagam L, Jain GK, Maurya R, Chattopadhyay N, Extract and fraction from Ulmus wallichiana Planchon promote peak bone achievement and have a nonestrogenic osteoprotective effect. Menopause (New York, N.Y.), 2010 Mar;17(2):393-4022010
Sharma A, Chakravarti B, Gupt MP, Siddiqui JA, Konwar R, Tripathi RP, Synthesis and anti breast cancer activity of biphenyl based chalcones. Bioorganic & medicinal chemistry, 2010 Jul 1;18(13):4711-202010
Siddiqui JA, Swarnkar G, Sharan K, Chakravarti B, Sharma G, Rawat P, Kumar M, Khan FM, Pierroz D, Maurya R, Chattopadhyay N, 8,8''-Biapigeninyl stimulates osteoblast functions and inhibits osteoclast and adipocyte functions: Osteoprotective action of 8,8''-biapigeninyl in ovariectomized mice. Molecular and cellular endocrinology, 2010 Jul 29;323(2):256-672010
Trivedi R, Kumar S, Kumar A, Siddiqui JA, Swarnkar G, Gupta V, Kendurker A, Dwivedi AK, Romero JR, Chattopadhyay N, Kaempferol has osteogenic effect in ovariectomized adult Sprague-Dawley rats. Molecular and cellular endocrinology, 2008 Jul 16;289(1-2):85-932008
Sharan K, Siddiqui JA, Swarnkar G, Chattopadhyay N, Role of calcium-sensing receptor in bone biology. The Indian journal of medical research, 2008 Mar;127(3):274-862008
Siddiqui JA, Partridge NC, CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone. Frontiers in endocrinology, 2017;8:49
Siddiqui JA, Singh A, Chagtoo M, Singh N, Godbole MM, Chakravarti B, Phytochemicals for breast cancer therapy: current status and future implications. Current cancer drug targets, 2015;15(2):116-35
Sharan K, Siddiqui JA, Swarnkar G, Maurya R, Chattopadhyay N, Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharma-cokinetic studies. Current medicinal chemistry, 2009;16(9):1138-57
Sharan K, Swarnkar G, Siddiqui JA, Kumar A, Rawat P, Kumar M, Nagar GK, Manickavasagam L, Singh SP, Mishra G, Wahajuddin, Jain GK, Maurya R, Chattopadhyay N, A novel flavonoid, 6-C-beta-d-glucopyranosyl-(2S,3S)-(+)-3',4',5,7-tetrahydroxyflavanone, isolated from Ulmus wallichiana Planchon mitigates ovariectomy-induced osteoporosis in rats. Menopause (New York, N.Y.), 2010 May-Jun;17(3):577-86

Editorial

Siddiqui JA, Nasser MW, Editorial: Role of chemokines in tumor heterogeneity. Seminars in cancer biology, 2023 Jul;92:128-1292023
Sharma G, Ponzetti M, Siddiqui JA, Editorial: Bone metastasis in the milieu of osteoimmunology. Frontiers in immunology, 2023;14:1265434
Sharma G, Dal Col J, Siddiqui JA, Editorial: Rising stars in molecular and cellular oncology 2022. Frontiers in oncology, 2023;13:1136335
Sharma G, Barbieri I, Blandino G, Poli V, Siddiqui JA, Editorial: Roles of non-coding RNAs in tumor growth and development. Frontiers in oncology, 2022;12:1098315

Honors, Awards, and Recognition

Young Investigator Award, Society for Basic Urologic Research (SBUR)2024
New Investigator Award, University of Nebraska Medical Center, Omaha
Young Investigator Award, American Association of Indian Scientists in Cancer Research (AAISCR), USA
Outstanding performance award, University of Nebraska Medical Center, Omaha, NE
Alice L. Jee Young Investigator Award, Orthopedic Research Society, USA
Young Investigator Grant, British Bone Research and ASBMR
Eight Fellows Forum on Metabolic Bone Diseases, Endocrine Fellows Foundation , USA

Professional Membership and Service

NYU Center for Skeletal and Craniofacial Biology, Member
Society for Basic Urologic Research, Member
Cancer Center Research Institute (CCRI), Member
American Society of Bone and Mineral research, Member
The New York Academy of Science, Member
The Endocrine Society, Fellow
International Bone and Mineral Society, Member
Endocrine Fellows Foundation, Member
Indian Society of Bone and Mineral Research, Member

Committee Service

SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-CURRICULUM, Member2024 - Present
Postdoc Mentoring Committee, Member

Fellows supervised

Cancer Research, Post-Doc Advisor, 3 fellows supervised