Daniela Rueedi-Bettschen, PhD

Daniela Rueedi-Bettschen, PhD

Assistant Professor

Department:
SOM-Psychiatry

Email:
drueedibettschen@umc.edu

Work Phone:
(601) 984-5890

Education

Neuroscience Center Zurich, Switzerland, PhD, International Ph.D. Program in Neuroscience2004
Laboratory of Behavioral Neurobiology, ETH Zurich, Zuric, PhD, Ph.D Behavioral Neuroscience2004
ETH Zurich (Eidgenössische Technische Hochschule Zürich), Zurich, Switzerland, MS, Biology of Behavior Studies2000
University of Bern, Bern, Switzerland, Veterinary Medicine Studies1995

Current Positions

Director Animal Behavior Core, School of Medicine11/2021 - Present
Assistant Professor, School of Medicine, Department of Psychiatry07/2021 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Associate Director CPN Animal Behavior Core, University of Mississippi Medical Center, School of Medicine, Department of Psychiatry08/2016 - 10/2021
Instructor, University of Mississippi Medical Center, School of Medicine, Department of Psychiatry10/2013 - 06/2021
Instructor, University of Arkansas for Medical Sciences, School of Medicine, Department of Pharmacology / Toxicology05/2008 - 08/2013
Postdoctroal Research Fellow, Harvard Medical School, New England Primate Research, School of Medicine01/2006 - 04/2008
Postdoctoral Research Fellow, ETH Zurich (Eidgenössische Technische Hochschule Zürich)2005 - 09/2005

Sponsored Program Funding

Extramural, Consequences of fentanyl self-administration during pregnancy, NIH/NIDA04/2021 - 03/2023
Extramural, GABA-A receptor subtype mechanisms and the abuse-related effects of alcohol, NIH/NIAAA09/2020 - 07/2025
Intramural, Methamphetamine use during pregnancy, NIH/NIGMS06/2020 - 05/2022
Intramural, Consequences of methamphetamine use during pregnancy, NIH/NIGMS06/2018 - 05/2019
Intramural, Long-term consequences of in utero methamphetamine exposure, NIH/NIGMS09/2014 - 07/2017
Extramural, Opioid Receptor Polymorphisms and Nonhuman Primate Models of Alcohol Abuse, NIH / NIAAA01/2009 - 01/2014
Extramural, Active Immunization for Treating Methamphetamine Abuse, NIH / NIDA01/2007 - 01/2013
Extramural, GABA-A receptor subtype mechanisms and the abuse-related effects of alcohol., NIH/NIAAA09/2006 - 07/2025
Extramural, GABAA-Receptor Subtype Mechanisms in Nonhuman Primate Models of Alcohol Abuse, NIH / NIAAA01/2006 - 01/2017
Extramural, Immunotherapy for Drug Abuse., NIH / NIDA01/1992 - 01/2009

Publications

Journal Article

Pareek T, Platt DM, Rüedi-Bettschen D, Daily, limited access to methamphetamine self-administration during pregnancy leads to increased methamphetamine sensitivity in adult offspring. Developmental psychobiology, 2023 Jan;65(1):e223502023
Golani L, Platt D, Rüedi-Bettschen D, Edwanker C, Huang S, Poe M, Furtmuller R, Sieghart W, Cook JM, Rowlett JK 8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABA A Receptor Front Pharmacol. 2021; 12:6252332021
Cook JE, Chandler C, Rüedi-Bettschen D, Taylor I, Patterson S, Platt DM, Changes in the elimination and resurgence of alcohol-maintained behavior in rats and the effects of naltrexone. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2020 Feb;34(1):10-222020
Meng Z, Berro LF, Sawyer EK, Rüedi-Bettschen D, Cook JE, Li G, Platt DM, Cook JM, Rowlett JK, Evaluation of the anti-conflict, reinforcing, and sedative effects of YT-III-31, a ligand functionally selective for α3 subunit-containing GABA(A) receptors. Journal of psychopharmacology (Oxford, England), 2020 Mar;34(3):348-3572020
Berro LF, Rüedi-Bettschen D, Cook JE, Golani LK, Li G, Jahan R, Rashid F, Cook JM, Rowlett JK, Platt DM, GABA(A) Receptor Subtypes and the Abuse-Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators. Alcoholism, clinical and experimental research, 2019 May;43(5):791-8022019
Stevens MW, Rüedi-Bettschen D, Gunnell MG, Tawney R, West CM, Owens SM, Antibody production and pharmacokinetics of METH in rats following vaccination with the METH vaccine, IXT-v100, adjuvanted with GLA-SE. Drug and alcohol dependence, 2019 Nov 1;204:1074842019
Rüedi-Bettschen D, Platt DM, Detrimental effects of self-administered methamphetamine during pregnancy on offspring development in the rat. Drug and alcohol dependence, 2017 Aug 1;177:171-1772017
Hambuchen MD, Rüedi-Bettschen D, Gunnell MG, Hendrickson H, Owens SM, Chronic treatment of (+)-methamphetamine-induced locomotor effects in rats using one or a combination of two high affinity anti-methamphetamine monoclonal antibodies. Human vaccines & immunotherapeutics, 2016 Sep;12(9):2240-82016
Hambuchen MD, Carroll FI, Rüedi-Bettschen D, Hendrickson HP, Hennings LJ, Blough BE, Brieaddy LE, Pidaparthi RR, Owens SM, Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response. Journal of medicinal chemistry, 2015 Jun 11;58(11):4665-772015
Rüedi-Bettschen D, Spealman RD, Platt DM, Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors. Psychopharmacology, 2015 Aug;232(16):2959-682015
Hambuchen MD, Rüedi-Bettschen D, Williams DK, Hendrickson H, Owens SM, Treatment of rats with an anti-(+)-methamphetamine monoclonal antibody shortens the duration of action of repeated (+)-methamphetamine challenges over a one month period. Vaccine, 2014 Oct 29;32(47):6213-92014
Rüedi-Bettschen D, Wood SL, Gunnell MG, West CM, Pidaparthi RR, Carroll FI, Blough BE, Owens SM, Vaccination protects rats from methamphetamine-induced impairment of behavioral responding for food. Vaccine, 2013 Sep 23;31(41):4596-6022013
Rüedi-Bettschen D, Rowlett JK, Rallapalli S, Clayton T, Cook JM, Platt DM, Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys. Alcoholism, clinical and experimental research, 2013 Apr;37(4):624-342013
Gentry WB, Rüedi-Bettschen D, Owens SM, Anti-(+)-methamphetamine monoclonal antibody antagonists designed to prevent the progression of human diseases of addiction. Clinical pharmacology and therapeutics, 2010 Sep;88(3):390-32010
Vallender EJ, Rüedi-Bettschen D, Miller GM, Platt DM, A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys. Drug and alcohol dependence, 2010 Jun 1;109(1-3):252-62010
Rüedi-Bettschen D, Rowlett JK, Spealman RD, Platt DM, Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms. Psychopharmacology, 2010 Jun;210(2):169-772010
Licata SC, Platt DM, Rüedi-Bettschen D, Atack JR, Dawson GR, Van Linn ML, Cook JM, Rowlett JK, Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes. Neuropharmacology, 2010 Feb;58(2):357-642010
Gentry WB, Rüedi-Bettschen D, Owens SM, Development of active and passive human vaccines to treat methamphetamine addiction. Human vaccines, 2009 Apr;5(4):206-132009
Valdez GR, Platt DM, Rowlett JK, Rüedi-Bettschen D, Spealman RD, Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms. The Journal of pharmacology and experimental therapeutics, 2007 Nov;323(2):525-332007
Leventopoulos M, Rüedi-Bettschen D, Knuesel I, Feldon J, Pryce CR, Opacka-Juffry J, Long-term effects of early life deprivation on brain glia in Fischer rats. Brain research, 2007 Apr 20;1142:119-262007
Rüedi-Bettschen D, Zhang W, Russig H, Ferger B, Weston A, Pedersen EM, Feldon J, Pryce CR, Early deprivation leads to altered behavioural, autonomic and endocrine responses to environmental challenge in adult Fischer rats. The European journal of neuroscience, 2006 Nov;24(10):2879-932006
Pryce CR, Rüedi-Bettschen D, Dettling AC, Weston A, Russig H, Ferger B, Feldon J Long-term effects of early-life environmental manipulations in rodents and primates: Potential animal models in depression research. Neurosci Biobehav Rev. 2005;29(4-5):649-742005
Mintz M, Rüedi-Bettschen D, Feldon J, Pryce CR, Early social and physical deprivation leads to reduced social motivation in adulthood in Wistar rats. Behavioural brain research, 2005 Jan 30;156(2):311-202005
Rüedi-Bettschen D, Pedersen EM, Feldon J, Pryce CR, Early deprivation under specific conditions leads to reduced interest in reward in adulthood in Wistar rats. Behavioural brain research, 2005 Jan 30;156(2):297-3102005
Rüedi-Bettschen D, Feldon J, Pryce CR, The impaired coping induced by early deprivation is reversed by chronic fluoxetine treatment in adult fischer rats. Behavioural pharmacology, 2004 Sep;15(5-6):413-212004
Rüedi-Bettschen D, Feldon J, Pryce CR, Circadian- and temperature-specific effects of early deprivation on rat maternal care and pup development: short-term markers for long-term effects? Developmental psychobiology, 2004 Sep;45(2):59-712004
Pryce CR, Bettschen D, Nanz-Bahr NI, Feldon J, Comparison of the effects of early handling and early deprivation on conditioned stimulus, context, and spatial learning and memory in adult rats. Behavioral neuroscience, 2003 Oct;117(5):883-932003
Pryce CR, Rüedi-Bettschen D, Dettling AC, Feldon J, Early life stress: long-term physiological impact in rodents and primates. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 2002 Aug;17:150-52002
Pryce CR, Bettschen D, Feldon J, Comparison of the effects of early handling and early deprivation on maternal care in the rat. Developmental psychobiology, 2001 May;38(4):239-512001
Pryce CR, Bettschen D, Bahr NI, Feldon J, Comparison of the effects of infant handling, isolation, and nonhandling on acoustic startle, prepulse inhibition, locomotion, and HPA activity in the adult rat. Behavioral neuroscience, 2001 Feb;115(1):71-832001
Lehmann J, Pryce CR, Bettschen D, Feldon J, The maternal separation paradigm and adult emotionality and cognition in male and female Wistar rats. Pharmacology, biochemistry, and behavior, 1999 Dec;64(4):705-151999
Golani LK, Platt DM, Rüedi-Bettschen D, Edwanker C, Huang S, Poe MM, Furtmüller R, Sieghart W, Cook JM, Rowlett JK, 8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABA(A) Receptor. Frontiers in pharmacology, 2021;12:625233

Abstracts

Sasser J, Platt DM, Rüedi-Bettschen D Extended access to methamphetamine self-administration leads to altered maternal physiology and impaired offspring development College on Problems of Drug Dependence 82nd Annual Meeting, Hollywood, FL.2020
Platt DM, Rüedi-Bettschen D, Cook LE, Li G, Poe M, Methuku K and Cook JM Contribution of alpha 2/3 GABA-A receptors to the abuse-related effects of ethanol in rhesus monkeys. Alcoholism: Clinical and Experimental Research. 2017; 41(S1):1A-363A2017
Rüedi-Bettschen D, Rallapalli S, Clayton T, Cook J, Platt D Reinforcing effects of ethanol are attenuated by α5GABAA receptor inverse agonists in monkeys Alcoholism: Clinical and Experimental Research. 2015; 39(S1): 12A–249A2015
Platt DM, Rüedi-Bettschen D, Rallapalli S, Cook JM Role of alpha-5/GABA(A) receptor mechanisms in the reinforcing effects of ethanol in monkeys. Behav Pharmacol 18, S29-302007
Rüedi-Bettschen D, Zhang W, Weston A, Feldon J, Pryce CR Postnatal Manipulation leads to increased behavioural and cardiophysiological reactivity to aversive challenge in adult Fischer rats Acta Neurobiologiae Experimentalis. 2003; 63(5): E342003

Book Chapter

Chandler CM, Overton JS, Rüedi-Bettschen D, Platt DM GABAA Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence Grant K., Lovinger D. (eds) The Neuropharmacology of Alcohol. Handbook of Experimental Pharmacology, vol 248. Springer, Cham, 20182017
Pryce CR, Rüedi-Bettschen D, Dettling AC, Feldon J Early-life environmental manipulations in rodents and primates: potential animal models in depression research. Handbook on Stress, Immunology and Behaviour Vol. 2. (Steckler T, Reul H, Kalin NH, eds). Amsterdam: Elsevier science, pp. 23-50.2005

Presentations

State/Local Invited Seminars/Lectures, Drug use during pregnancy: lessons from a translationally- relevant rat model, Psychiatry Grand Rounds, UMMC02/2022
Platform Presentations, Sex differences in offspring of maternal methamphetamine use, American Physiological Society; New Trends in Sex and Gender Medicine, Virtual Meeting10/2021
Poster Presentation, Fentanyl abuse during pregnancy: deleterious effects on offspring development, MS IdeA, Jackson, MS07/2018
Poster Presentation, Combination with pregnanolone increases the sedative effects of triazolam and zolpidem in rhesus macaques, CPDD, San Diego, CA06/2018
Platform Presentations, In utero exposure to moderate doses of methamphetamine alters sensitivity to the same drug in adults, College on Problems of Drug Dependence, Montreal, Canada07/2017
Poster Presentation, Methamphetamine self-administration during pregnancy in the rat: effects on dams and offspring., NIH, NIGMS Biennial IdeA Symposium of Biomedical Research Excellence, Washington, DC07/2016
Poster Presentation, Consequences of self-administered methamphetamine throughout pregnancy on rat dams and their offspring., SE Regional IDeA Meeting, Biloxi, MS11/2015
Poster Presentation, Consequences of self-administered methamphetamine throughout pregnancy on rat dams and their offspring., Society for Neuroscience, Chicago, IL10/2015
Poster Presentation, Reinstatement of drug-seeking behavior in rats trained to self-administer intravenous injections of midazolam, The College on Problems of Drug Dependence, Phoenix, AZ06/2015
Poster Presentation, Safety and efficacy of a novel anti-(+)-methamphetamine (METH) vaccine, The Collegeon Problems of Drug Dependence, Palm Springs, CA06/2012
Poster Presentation, Efficacy and safety of chronic anti(+)-methamphetamine mAb7F9 treatment of (+)-methamphetamine (METH) induced locomotor activity in rats., AAPS National Biotechnology Conference, San Diego, CA05/2012
Poster Presentation, Effects of early life stress on behaviour and hippocampal volume in adult Wistar and Lewis rats, Federation of European Neuroscience Societies, Amsterdam, Netherlands07/2010
Poster Presentation, Alpha-5/GABAA receptor mechanisms and the reinforcing effects of ethanol in monkeys, College on Problems of Drug Dependence, San Juan, Puerto Rico06/2008
National and International Invited Seminars/Lectures, The use of non-human primates in addiction research: Impact of receptor mechanisms on substance abuse and relapse, Universitäre Psychiatrische Kliniken, Basel, Switzerland04/2008
Poster Presentation, Involvement of 5-HT2C receptor mechanisms in the serotonergic modulation of cocaine priming-induced reinstatement in squirrel monkeys, Society for Neuroscience, San Diego, CA10/2007
Poster Presentation, Serotonergic modulation of cocaine priming-induced reinstatement: focus on 5-HT2C receptor mechanisms, College on Problems of Drug Dependence, Quebec City, Canada06/2007
Poster Presentation, Early deprivation leads to reduced motivation for reward that can be restored with fluoxetine in adult Wistar rats, Society for Neuroscience, San Diego, CA10/2006
Poster Presentation, Mu opioid receptor polymorphisms and naltrexone response in rhesus monkeys trained to self-administer alcohol, Society for Neuroscience, Atlanta, GA10/2006
Poster Presentation, Effects of early maternal deprivation on anxiety- and depression-like behaviour and regional density of insulin receptors in adult Wistar rats, Federation of European Neuroscience Societies, Lisbon, Portugal07/2004
Poster Presentation, Postnatal Manipulation leads to increased behavioural and cardiophysiological reactivity to aversive challenge in adult Fischer rats, Society for Neuroscience, New Orleans, LA11/2003
Platform Presentations, Early Deprivation leads to reduced motivation and increased behavioural despair in the adult rat, International Behavioral Neuroscience Society06/2002

Honors, Awards, and Recognition

Excellence in Research – Silver Medal Award, University of Mississippi Medical Center2021
Young Investigator Travel Award, NIH, NIGMS Biennial National IdeA Symposium of Biomedical Research Excellence2016
Travel Award, The College on Problems of Drug Dependence2007
Smotherman-Hennessey-Wiley Award, Best student paper published in Developmental Psychobiology2005
Travel Award, Swiss Society for Neuroscience2003
Travel Award, International Behavioral Neuroscience Society2002

Professional Membership and Service

The College on Problems of Drug Dependence, Member2019 - Present
American Association of Pharmaceutical Scientists, Member2012
International Study Group Investigating Drugs as Reinforcers, Member2010 - Present
Society for Neuroscience, Member2008 - Present
Swiss Society for Neuroscience, Member2003 - 2005

Committee Service

MEDICAL CENTER-ANIMAL CARE AND USE, Member2022 - Present
Institutional Animal Care and Use Committee, Member2012 - 2013
Department of Animal Laboratory Medicine Advisory Committee, Member2009 - 2013
Needle stick Committee, Member2007 - 2008

Teaching Experience

NSCI701, Graduate, Course, Lecturer, Foundations of NeuroscienceSpring 2022
NSCI 701, Graduate, Course, Lecturer, Foundations of NeuroscienceSpring 2021
NSCI 708, Graduate, Course, Lecturer, Special Topics in NeuroscienceSummer 2020
NSCI 701, Graduate, Course, Lecturer, Foundations of NeuroscienceSpring 2020
701, Graduate, Course, Lecturer, Foundations of NeuroscienceSpring 2019
NSCI 701, Graduate, Course, Lecturer, Foundations of NeuroscienceSpring 2018
NSCI 701, Graduate, Course, Lecturer, Foundations in NeuroscienceSpring 2017
NSCI 701, Graduate, Course, Lecturer, Foundations in NeuroscienceSpring 2016
NSCI 701, Graduate, Course, Lecturer, Foundations in NeuroscienceSpring 2015

Directed Student Learning

Supervised Research, Advised: David Majure2019 - 2019
Supervised Research, Advised: Ray Antonyraj2018 - 2018
Supervised Research, Advised: Mitchell Read2017 - 2017
Supervised Research, Advised: Brett Westbrook2009 - 2009
Supervised Research, Advised: Eileen Kessler2007 - 2007
Supervised Research, Advised: Anna Weston2003 - 2003