Richard J. Roman, PhD

Professor

Department:
SOM-Pharmacology/Toxicology

Email:
rroman@umc.edu

Work Phone:
(601) 984-1602

Education

University of Tennessee Centers for Health Science, PhD, Pharmacology	1977
Rutgers University, BS, Chemical Engineering	1973

Current Positions

Professor, School of Medicine, Department of Pharmacology / Toxicology	10/2009 - Present
The University of Mississippi Medical Center Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Director, Medical College of Wisconsin, Milwaukee, WI, Department of Kidney Disease Center	2004 - 2009
Professor, Medical College of Wisconsin, Milwaukee, WI, School of	1990 - 2009
Assistant Professor, Pennsylvania State University, School of Medicine, Department of Cellular and Molecular Physiology	06/1998 - 05/1999
Instructor, Pennsylvania State University, School of Medicine, Department of Cellular and Molecular Physiology	07/1997 - 06/1998
Associate Professor, Medical College of Wisconsin, Milwaukee, WI, School of , Department of Physiology And Biophysics	1986 - 1990
Assistant Professor, Medical College of Wisconsin, Milwaukee, WI, School of , Department of Physiology And Biophysics	1981 - 1986
Harvard Medical School, Boston, MA, School of	1980 - 1981
Harvard Medical School, Boston, MA, School of	1979 - 1981
Harvard Medical School, School of Medicine	1977 - 1979
Teaching Assistant and Graduate Student, University of Tennessee Center for the Health Sciences, School of	1973 - 1977

Publications

Journal Article
Akbulut T, Regner KR, Roman RJ, Avner ED, Falck JR, Park F. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through EGFR- and c-Src-dependent mechanism. Am J Physiol Renal Phys. 2009; 297(3): F662-F670.	2009
Akbulut T, Regner KR, Roman RJ, Avner ED, Falck JR, Park F 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through EGFR- and c-Src-dependent mechanism Am J Physiol Renal Phys. 2009; 297(3): F662-F670
Alonso-Galicia M, Falck JR, Roman RJ. 20-HETE agonists and antagonists in the renal circulation. Am. J. Physiol. 1999; 277:F790-F796.
Frisbee JC, Roman RJ, Falck JR, Lombard JH. 20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague Dawley rats Microvascular Res. 2001; 8: 45-55.
Roman RJ, Akbulut T, Park F, Regner KR. 20-HETE in acute renal injury. Kidney Int. 2010; 79:10-13.
Ma Y-H, Gebremedhin D, Schwartzman ML, Clark JE, Harder DR, Masters BS, Roman RJ. 20-HETE is an endogenous vasoconstrictor of dog renal arcuate arteries. Circ. Res. 1993; 72:126-136.
Nilakantan V, Maenpaa C, Jia G, Roman RJ, Park F 20-HETE mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells Am J Physiol Renal Physiol. 2008;294(3): F562-570, 2008
Nilakantan V, Maenpaa C, Jia G, Roman RJ, Park F. 20-HETE mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells. Am J Physiol Renal Physiol. 2008;294(3): F562-570, 2008.
Frisbee JC, Roman RJ, Falck JR, Lombard JH. 20-HETE modulates myogenic activation of skeletal muscle resistance arteries from hypertensive, but not normotensive Dahl S rats. Am J. Physiol.Heart Circ Physiol. 2001; 280:H1066-H1074.
Yu M, Alonso-Galicia M, Sun CW, Roman RJ, Ono N, Hirano H, Ishimoto T, Reddy YK, Reddy KM, Gopal VR, Yu J, Takhi M, and Falck JR 20-Hydroxyeicosatetraenoic Acid (20-HETE): structural determinants for renal vasoconstriction Bioorganic Med Chem. 2003; 11:2803-2821
Yu M, Alonso-Galicia M, Sun CW, Roman RJ, Ono N, Hirano H, Ishimoto T, Reddy YK, Reddy KM, Gopal VR, Yu J, Takhi M, and Falck JR. 20-Hydroxyeicosatetraenoic Acid (20-HETE): structural determinants for renal vasoconstriction. Bioorganic Med Chem. 2003; 11:2803-2821.
Zou A-P, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ. 20-hydroxyeicosatetraenoic acid is an endogenous inhibitor of the large conductance Ca++-activated K+-channel in renal arterioles. Am. J. Physiol. 1996; 270 (Reg. Int. and Comp. Physiol. 39):R228-R237.
Williams JM, Murphy S, Burke M, Roman RJ 20-hydroxyeicosatetraenoic acid: a new target for the treatment of hypertension J Cardiovasc. Pharmacol. 2010; 56:336-344
Williams JM, Murphy S, Burke M, Roman RJ. 20-hydroxyeicosatetraenoic acid: a new target for the treatment of hypertension. J Cardiovasc. Pharmacol. 2010; 56:336-344.
Guo M, Roman RJ, Fenstermacher JD Brown S Falck JR Arbab AS, Edwards PA, Scicli AG 9L Gliosarcoma Cell Proliferation and Tumor Growth are Suppressed by HET0016, a Selective Inhibitor of CYP4A J Pharmacol Exp Ther. 2006; 317:97-108
Guo M, Roman RJ, Fenstermacher JD Brown S Falck JR Arbab AS, Edwards PA, Scicli AG. 9L Gliosarcoma Cell Proliferation and Tumor Growth are Suppressed by HET0016, a Selective Inhibitor of CYP4A. J Pharmacol Exp Ther. 2006; 317:97-108.
Tunctan B, Korkmaz B, Buharalioglu CK, Firat SS, Anjaiah S, Falck J, Roman RJ, Malik KU A 20-hydroxyeicosatetraenoic acid agonist, N-[20-HYDROXYEICOSA-5(Z),14(Z)-DIENOYL]GLYCINE, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats Shock. 2008; 30(3): 329-35
Tunctan B, Korkmaz B, Buharalioglu CK, Firat SS, Anjaiah S, Falck J, Roman RJ, Malik KU. A 20-hydroxyeicosatetraenoic acid agonist, N-[20-HYDROXYEICOSA-5(Z),14(Z)-DIENOYL]GLYCINE, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats. Shock. 2008; 30(3): 329-35.
Harder DR, Roman RJ, Gebremedhin D, Lange AR. A common pathway for regulation of nutritive blood flow to the brain: Arterial muscle membrane potential and cytochrome P450 metabolites. Acta Physiol Scand. 1998; 164:527-532.
Alonso-Galicia M, Hudetz AG, Shen H, Harder DR, Roman RJ. A fall in 20-HETE contributes to the vasodilator actions of NO in the cerebral microcirculation. Stroke. 1999; 30:2727-2734.
Roman RJ, Bonventre JV Bonventre Lechene CP. A fluorometric assay for urea in urine, plasma, and tubular fluid. Anal. Biochem. 1979; 98:136-141.
Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Shork NJ, Wang Z, and Jacob HJ. A genomic-systems biology map for cardiovascular function. Science. 2001; 294: 1723-1726.
Roman RJ, and Cowley AW, Jr. Abnormal pressure-diuresis-natriuresis response in spontaneously hypertensive rats. Am. J. Physiol. 248 (Renal Fluid Electrolyte Physiol. 17): 1985; 199-205.
Moreno C, Maier KG, Hoagland KM, Wu M, Roman RJ. Abnormal pressure-natriuresis in hypertension: Role of cytochrome P450 metabolites of arachidonic acid. Am. J. Hypertension. 2001; 14:90S-97S..
Gross V, Roman RJ, Cowley Jr AW. Abnormal pressure-natriuresis in transgenic renin gene rats. J. Hypertension. 1995; 12:1029-1034, 1994.
Roman RJ. Abnormal renal hemodynamics and pressure diuresis response in Dahl salt-sensitive rats. Am. J. Physiol. 251 (Renal Fluid Electrolyte Physiol. 20). 1986; F57-F65.
Imig JD, Roman RJ, Navar LG, Falck JR. Actions of epoxygenase metabolites on the preglomerular vasculature. J.A.S.N. 1996; 7:2364-2370.
Guo AM, Arbab AS, Falck JR, Chen P, Edwards PA, Roman RJ and Scicli AG Activation of VEGF Through ROS Mediates 20-HETE-Induced Endothelial Cell Proliferation J Pharm Exp Therap. 2007; 321:18-27
Guo AM, Arbab AS, Falck JR, Chen P, Edwards PA, Roman RJ and Scicli AG. Activation of VEGF Through ROS Mediates 20-HETE-Induced Endothelial Cell Proliferation. J Pharm Exp Therap. 2007; 321:18-27.
Roman RJ, Alonso-Galicia M. Alterations in renal hemodynamics and glomerular and vascular injury in hypertension. Current Concepts in Hypertension. 1998; 2:4-5.
Parekh V, Maier KG, Roman RJ, Joshua IG, Falcone JC, Passmore JC. Altered expression and activity of G-proteins, mitogen activated protein kinases and tyrosine kinases in the kidney cortex of aging rats. J. Invest. Med. 1999; 47:462-467.
Frisbee JC, Roman RJ, Falck JR, Lombard JH. Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries between hypertensive and normotensive Dahl rats. Microcirculation. 2001; 8:115-127.
Roman RJ Altered pressure-natriuresis relationship in young spontaneously hypertensive rats. Hypertension 9 (suppl. III) 1987; 130-136.
Zawieja D, Barber BJ Barber Roman RJ. Analysis of picogram quantities of protein in subnanoliter size samples. Anal. Biochem. 1984; 142:182-188.
Reckelhoff JF, Roman RJ Androgen and hypertension: Role males and females> Hypertension. 2011; 57:681-682.
Chen JX, Stinnett A, Roman RJ Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice Diabetes. 2008; 57(12):3335-43
Chen JX, Stinnett A. Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice. Diabetes. 2008; 57(12):3335-43.
Tuo QH, Xiong GZ, Zeng H, Yu HD, Sun SW, Ling HY, Zhu BY, Liao DF, Chen JX. Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition. Acta Pharmacol Sin, 2011; 32(1):45-51
Yamaguchi Y, Fenoy FJ, Roman RJ, Nasjletti A. Angiotensin II influences the renal hemodynamic response to blockade of thromboxane A2 and prostaglandin H2 receptors. J. Pharmacol. Exp. Ther. 1992; 263:905-909, 1992.
Gans KR, Galbraith W, Roman RJ, Haber SB, Kerr JS, Schmidt WK, Smith C, Hewes WE, Roman RJ, Ackerman NR. Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin inhibitor. J. Pharmacol. Exp. Ther. 1990; 254:180-187. 1990.
Dahly AJ, Hoagland KM, Flasch AK, Jha S, Ledbetter SR, and Roman RJ. Antihypertensive effect of anti-TGF-beta antibody therapy in Dahl S rats. Am. J. Physiol. 2002; 283:R757-R767.
Yu M, Moreno-Quinn C, Hoagland K, Dahly A, Ditter K, Mistry M and Roman RJ. Antihypertensive effect of glucagon-like peptide in Dahl S rats J Hypertension. 2003; 21:1125-1135
Yu M, Moreno-Quinn C, Hoagland K, Dahly A, Ditter K, Mistry M and Roman RJ. Antihypertensive effect of glucagon-like peptide in Dahl S rats. J Hypertension. 2003; 21:1125-1135.
Xu F, Straub WO, Pak W, Su P, Maier KG, Yu M, Roman RJ. Ortiz de Montellano PR, and Kroetz DL. Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid w-hydroxylase activity. Am. J. Physiol. 2002; 283: R710-R720.
Williams JM, Fan F, Murphy S, Lazar J, Jacob HJ, and Roman RJ. Antihypertensive effects of substitution of chromosome 5 from the BN rat onto the Dahl S genetic background are associated with upregulation of the renal formation of 20-HETE. In press
Cowley AW Jr, Roman RJ, Jacob HJ Application of chromosomal substitution techniques in gene-function discovery J. Physiol. 2004; 554:46-55
Cowley AW Jr, Roman RJ, Jacob HJ. Application of chromosomal substitution techniques in gene-function discovery. J. Physiol. 2004; 554:46-55.
Lu S, Mattson DL, Becker CB, Roman RJ, Cowley AW. Assessment of changes in intrarenal blood flow in conscious rats using laser-Doppler flowmetry Am. J. Physiol. 1993; 264 (Renal Fluid Electrolyte Physiol. 33):F956-F962.
Koehler RC, Roman RJ, Harder DR Astrocytes and the regulation of cerebral blood flow Trends in Neuroscience. 2009; 32(3):160-169
Koehler RC, Roman RJ, Harder DR. Astrocytes and the regulation of cerebral blood flow. Trends in Neuroscience. 2009; 32(3):160-169.
Takezawa K, Cowley AW Jr, Skelton MM, Roman RJ. Atriopeptin III alters renal medullary hemodynamics and the pressure diuresis response in rats. Am. J. Physiol. 252 (Renal Fluid Electrolyte Physiol. 21). 1987; F992-F1002.
Mattson DL, Roman RJ, Cowley AW. Autoregulation of blood flow in different regions of the kidney. Am. J. Physiol. 1993; 264 (Reg. Integ. Comp. Physiol. 33):R578-R583.
Roman RJ. Autoregulation of blood flow. In: Primer of Hypertension. ed by J. Izzo and H. R. Black. 1999, pp. 95-97
Roman RJ. Autoregulation of renal and cerebral blood flow. In: Hypertension Primer. ed by J.L. Izzo and H.R. Block. American Heart Association, Dallas 1993, pp. 85-87
Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, Bandou K, Kametani K, Sato M, Okuyama S, Cambj-Sapunar L, Harder DR and Roman RJ Beneficial Effects of a new 20-HETE Synthesis Inhibitor, TS-011 on hemorrhagic and Ischemic Stroke J Pharm and Exp Therap. 2005; 314:77-85
Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, Bandou K, Kametani K, Sato M, Okuyama S, Cambj-Sapunar L, Harder DR and Roman RJ. Beneficial Effects of a new 20-HETE Synthesis Inhibitor, TS-011 on hemorrhagic and Ischemic Stroke. J Pharm and Exp Therap. 2005; 314:77-85.
Kehl F, Okamoto H, K.G. Maier KG, Harder DR, Miyata N, Roman RJ. Blockade of 20-HETE formation attenuates cerebral vasospasm following subarachnoid hemorrhage in the rat. Am. J Physiol. 2002; 282:H1556-H1565.
Hoagland KM, Flasch AK, and Roman RJ Blockade of renal 20-HETE formation promotes salt-sensitive hypertension in rats Hypertension. 2003; 42:669-673
Hoagland KM, Flasch AK, and Roman RJ. Blockade of renal 20-HETE formation promotes salt-sensitive hypertension in rats. Hypertension. 2003; 42:669-673.
Tyml K, Roman RJ, Lombard JH. Blood flow measurements in skeletal muscle. In: Laser-Doppler Flowmetry. Edited by A.P. Shepard and P.A. Oberg. Norwell, MA: Kluwer Academic Press 1990, pp. 215-226, 1990.
Smits G, Roman RJ, Lombard J. Calibration of laser-doppler flowmeter for measurement of microvascular flows. J. Appl. Physiol. 1986; 61:666-671.
Roman RJ, Harder DR. Cellular and ionic signal transduction pathways for mechanical activation of renal arterial vascular smooth muscle. J. Am. Soc. Nephrol. 1993; 4:986-996.
Gebremedhin D, Ma Y-H, Roman RJ, Rollins M Van, Falck JR, Harder DR. Cellular mechanism of cerebral epoxyeicosatrienoic acids (EETs) on cat cerebral arterial smooth muscle. Am. J. Physiol. 1992; 263 (Heart Circ. Physiol. 32):H519-H525.
Yu M, Sun CW, Maier K, Harder DR, Roman RJ. cGMP-dependent desensitization to calcium contributes to the vasodilator response to NO in rat middle cerebral arteries. Am J. Physiol Heart Circ Physiol. 2002; 282:H1724-H1731.
Roman, RJ, and Cowley AW, Jr. Characterization of a new model for the study of pressure-natriuresis in the rat. Am. J. Physiol. 248 (Renal Fluid Electrolyte Physiol. 17). 1985 F190-F198.
Roman RJ, Hoagland KM, Alonso-Galicia M, Maier KM, Flasch AK, Aebly MR, Jacob HJ, Garrett MR, Rapp JP, and Roman RJ Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats Am J Physiol. 2006; 290: F1463-71
Roman RJ, Hoagland KM, Alonso-Galicia M, Maier KM, Flasch AK, Aebly MR, Jacob HJ, Garrett MR, Rapp JP, and Roman RJ. Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. Am J Physiol. 2006; 290: F1463-71.
Mattson DL, Dwinell MR, Green AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats Am J Physiol . 2007; 293:F1905-1914
Mattson DL, Dwinell MR, Green AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ. Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. Am J Physiol . 2007; 293:F1905-1914.
Stekiel TA, Contney SJ, Bosnjak ZJ, Kampine JP, Roman RJ, Stekiel WJ Chromosomal substitution-dependent differences in cardiovascular responses tosodium pentobarbital Anesth Analg. 2006; 102(3):799-805
Stekiel TA, Contney SJ, Bosnjak ZJ, Kampine JP, Roman RJ, Stekiel WJ. Chromosomal substitution-dependent differences in cardiovascular responses tosodium pentobarbital. Anesth Analg. 2006; 102(3):799-805.
Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob H, and Cowley, AW Jr Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease Am J Physiol. 2008; 295(3): F837-F842
Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob H, and Cowley, AW Jr. Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. Am J Physiol. 2008; 295(3): F837-F842.
Park F, Sweeney WE, Jia G, Akbulut T, Mueller B, Falck JR, Birudaraju S, Roman RJ, Avner EA Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD Am J Physiol. 2009; 296: F575-582
Park F, Sweeney WE, Jia G, Akbulut T, Mueller B, Falck JR, Birudaraju S, Roman RJ, Avner EA. Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. Am J Physiol. 2009; 296: F575-582.
Roman RJ, Ma Y-H, Frohlich B, Markham B. Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats. Hypertension. 1993; 21:985-988.
Wang M-H, Stec DE, Mastyugin V, Yang CS, Roman RJ, Schwartzman L. Cloning, sequencing and cDNA-directed expression of the rat renal CYP4A2 as an arachidonic acid w-hydroxylase. Biochem Biophys Acta. 1996; 336:240-250.
Gebremedhin D, Kaldunski M, Jacobs ER, Harder DR, Roman RJ. Coexistence of two types of Ca++-activated K+ channels in rat renal arterioles. Am. J. Physiol. 1996; 270 (Renal Fluid and Electrolyte Physiol. 39): F69-F81.
Roman RJ, Dahly-Vernon AJ, Dunn KM, Williams JM, Schreck C., Ledbetter S. Combination therapy of anti-TGF-β antibody and antihypertensive treatments on the development of hypertension and renal disease in Dahl S rats. Am J Physiology Renal Physiol 00:000-000, 2012 (In press).
Cowley AW Jr, Liang M, Roman RJ, Greene AS, Jacob HJ Consomic rat model systems for physiological genomics Acta Physiol Scand. 2004; 181: 585-92
Cowley AW Jr, Liang M, Roman RJ, Greene AS, Jacob HJ. Consomic rat model systems for physiological genomics. Acta Physiol Scand. 2004; 181: 585-92.
Hoagland KM, Maier KG and Roman RJ. Contribution of 20-HETE to the antihypertensive effects of tempol in Dahl salt-sensitive rats. Hypertension. 2003; 41:697-702.
Park F, Sweeney WE, Jia G, Roman RJ and Avner ED Contribution of 20-HETE tp the abnormal proliferation of renal epithelial cells in the BPK mouse JASN 19(10): 2008; 1929-1039
Park F, Sweeney WE, Jia G, Roman RJ and Avner ED. Contribution of 20-HETE tp the abnormal proliferation of renal epithelial cells in the BPK mouse. JASN 19(10): 2008; 1929-1039.
Campur-Sapunar L, Yu M, Maier KM, Harder DR and Roman RJ Contribution of 5HT1b receptors and 20-HETE to the fall in cerebral blood flow following SAH Stroke. 200334:1269-1275
Campur-Sapunar L, Yu M, Maier KM, Harder DR and Roman RJ. Contribution of 5HT1b receptors and 20-HETE to the fall in cerebral blood flow following SAH. Stroke. 200334:1269-1275.
Sun C-W, Falck JR, Harder DR, Roman RJ. Contribution of cGMP versus 20-HETE in mediating K+ channel and vasodilator responses to NO in rat middle cerebral arteries. Am J Physiol Heart Circ Physiol. 2000; 279:H339 50.
Frisbee JC, Roman RJ, Falck JR, Lombard JH. Contribution of cytochrome P4504A enzymes to skeletal muscle resistance arterial oxygen and myogenic responses. Microvasc. Res. 2000; 60:37-48.
Nakanishi K, Mattson DL, Gross V, Roman RJ, Cowley Jr AW. Control of renal medullary blood flow by V1 and V2 receptors. Am. J. Physiol. 1995; 269 (Reg. Int. Comp. Physiol. 39):R193-R200.
Cowley AW Jr, Roman RJ. Countercurrent exchange in the renal medulla Am J Physiol Regul Integr Comp Physiol. 2003; 284:R1151
Cowley AW Jr and Roman RJ. Countercurrent exchange in the renal medulla. Am J Physiol Regul Integr Comp Physiol. 2003; 284:R1151.
Cowley AW Jr, Roman RJ. Countercurrent exchange in the renal medulla. Am J Physiol Regul Integr Comp Physiol. 2003; 284:R1151.
Tuo QH, Zeng H, Stinnett A, Yu HD, Aschner JL, Chen JX Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis Am J Physiol Heart Circ Physiol, 2008; 294(6):H2547-57
Tuo QH, Zeng H, Stinnett A, Yu HD, Aschner JL, Chen JX Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis. Am J Physiol Heart Circ Physiol, 2008; 294(6):H2547-57.
Chen JX, Stinnett A. Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high fat diet-induced obesity Lab Invest. 2008; 88:1316-1328
Chen JX, Stinnett A. Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high fat diet-induced obesity. Lab Invest. 2008; 88:1316-1328.
Amaral SL, Maier KG, Roman RJ, and Greene AS. CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis. Am J Physiol. Heart Circ Physiol. 2003; 284:H1528-H1535.
Kunert MP, Roman RJ, Alonso-Galicia M, Falck JR, Lombard JH. Cytochrome P-450 w-hydroxylase: A potential O2 sensor in rat arterioles and skeletal muscle cells. Am J. Physiol. 2001; 280:280:H1840-1845.
Pavlov TS, Ilatovskay DV, Roman RJ and Staruschenko A. Cytochrome P-450 metabolites of arachidonic acid inhibit the epithelial Na+ channel (ENaC). Am J Physiol Renal Physiol 2011; 301:F672-F681.
Lombard JH, Roman RJ, Harder DR, Jackson WF. Cytochrome P-450 ω-hydroxylase senses O2 in hamster muscle, but not in cheek pouch epithelium. Am J Physiol. 1999; 276:H503-H507.
Sarkis A, Ito O, Mori T, Kohzuki M, Ito S, Verbalis J, Cowley AW Jr and Roman RJ Cytochrome P45 dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus Am J Physiol. 2005; 289: F1333-40
Sarkis A, Ito O, Mori T, Kohzuki M, Ito S, Verbalis J, Cowley AW Jr and Roman RJ. Cytochrome P45 dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus. Am J Physiol. 2005; 289: F1333-40.
Messer I, Bernard N, Roman RJ, Sassard J, Benzoni D. Cytochrome P450 arachidonate metabolite inhibition improves renal function in Lyon hypertensive rats. Am. J. Hypertens. 1999; 12:398-404.
Harder DR, Lange A, Gebremendhin D, Roman RJ. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. J. Vasc. Res. 1997; 34:237-243.
Yousif MH, Benter IF, Roman RJ. Cytochrome P450 metabolites of arachidonic acid play a role in cardiac dysfunction in diabetic rats following ischaemic reperfusion injury J Auton and Autacoid Pharmacolog. 2009; 29:33-41
Yousif MH, Benter IF, Roman RJ. Cytochrome P450 metabolites of arachidonic acid play a role in cardiac dysfunction in diabetic rats following ischaemic reperfusion injury. J Auton and Autacoid Pharmacolog. 2009; 29:33-41.
Hoagland KM, Maier KG, Moreno C, Yu M, Roman RJ. Cytochrome P450 metabolites of arachidonic acid: novel regulators of renal function. Nephrol Dial Transplant. 2001; 16:2283-2285.
Stec DE, DengAY, Rapp JP, Roman RJ. Cytochrome P4504A genotype cosegregates with hypertension in Dahl S rats. Hypertension. 1996; 27 (part 2):564-568.
Park SW, Shen X, Tien L-T, Roman RJ, Ma T. Differential action of methamphetamine on tyrosine hydroxylase and dopamine transport in the nigrostriatal pathway of mu-opioid receptor knockout mice. Int J. Neuroscience 2012 (in press) 00:000-000
Kunert MP, Roman RJ, Falck JR, Lombard JH. Differential effect of cytochrome P-450 w-hydroxylase inhibition on O2 induced constriction of arterioles in SHR with early and established hypertension. Microcirculation. 2001; 8: 435-443.
Strick DM, Ficksen-Olsen MJ, Lockhart JC, Roman RJ, Romero JC. Direct measurement of renal medullary blood flow in the dog. Am. J. Physiol. 1994; 267 (Reg. Int. Comp. Phyisol. 36):R253-R259.
Roman RJ, Carmines PK, Loutzenhiser R, Conger JD. Direct studies on the control of the renal microcirculation. J. Am. Soc. Nephrology. 1991; 2:136-149.
Chen JX, Stinnett A Disruption of Ang-1/Tie-2 signaling contributes to the impaired myocardial vascular maturation and angiogenesis in type II diabetic mice Arterioscler Thromb Vasc Biol, 28:1606-1613, 2008
Chen JX, Stinnett A. Disruption of Ang-1/Tie-2 signaling contributes to the impaired myocardial vascular maturation and angiogenesis in type II diabetic mice. Arterioscler Thromb Vasc Biol, 28:1606-1613, 2008
Wiessner JH, Garrett MR, Roman RJ and Mandel NS Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains Am J Physiol Renal Physiol. 2009; 297: F301-306
Wiessner JH, Garrett MR, Roman RJ and Mandel NS. Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains. Am J Physiol Renal Physiol. 2009; 297: F301-306.
Stec DE, Flasch A, Roman RJ, White JA Distribution of Cytochrome P450 4A and 4F isoforms along the nephron in mice. Am J Physiol Renal Physiol. 2003; 284: F95-F102.
Roman RJ, Lombard JH Does 20-hydroxyeicosatetraenoic acid contribute to sex differences in cardiovascular risk by increasing oxidative stress? Hypertension. 2007; 50:37-38
Roman RJ and Lombard JH. Does 20-hydroxyeicosatetraenoic acid contribute to sex differences in cardiovascular risk by increasing oxidative stress? Hypertension. 2007; 50:37-38.
Alexanian A, Rufanova VA, Miller B, Flasch A, Roman RJ, Sorokin A Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth Anticancer Res. 2009; 29:3819-24
Alexanian A, Rufanova VA, Miller B, Flasch A, Roman RJ, Sorokin A. Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth. Anticancer Res. 2009; 29:3819-24.
Chen JX, Chen Y, DeBusk L, Lin W, Lin PC. Dual functional roles of Tie-2/angiopoietin in TNF-alpha-mediated angiogenesis. Am J Physiol Heart Circ Physiol. 2004; 287(1):H187-95.
Lu L, Li P, Yang C, Kurth T, Misale M, Skelton MM, Moreno C, Roman RJ, Greene AS, Jacob HJ, Lazar J, Liang M, Cowley Jr AW Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension Physiol Genomics. 2010; 41: 63-70
Lu L, Li P, Yang C, Kurth T, Misale M, Skelton MM, Moreno C, Roman RJ, Greene AS, Jacob HJ, Lazar J, Liang M, Cowley Jr AW. Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiol Genomics. 2010; 41: 63-70.
Evans RG, Day K, Roman RJ, Hopp KH, Anderson WP. Efects of intrarenal infusion of 17-ODYA on renal antihypertensive mechansims in anesthetized rabbits. Am J Hypertenison. 1998; 11:803-812.
Renic M , Klaus JA, Omura T, Kawashima N, Onishi M, Miyata N, Koehler RC, Harder DR, and Roman RJ. Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. J Cerebral Blood Flow and Metabolism. 2009; 29:629-639.
Omura T, Tanaka Y, Miyata N, Koizumi C, Sakurai T, Fukasawa M, Hachiuma K, Minagawa T, Susumu T, Yosida S, Nakaike S, Shigeru O, Harder DR and Roman RJ Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury Stroke. 2006; 37:1307-13
Omura T, Tanaka Y, Miyata N, Koizumi C, Sakurai T, Fukasawa M, Hachiuma K, Minagawa T, Susumu T, Yosida S, Nakaike S, Shigeru O, Harder DR and Roman RJ. Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. Stroke. 2006; 37:1307-13.
Fenoy FJ, Scicli G, Carretero O, Roman RJ. Effect of angiotensin II and kinin receptor antagonists on the renal hemodynamic and excretory responses to captopril. Hypertension. 1991; 17:1038-1044.
Fenoy FJ, Milicic I, Mistry M, Mecca TE, Roman RJ. Effect of clintiazem on arterial pressure and renal function in normotensive and hypertensive rats. J. Pharmacol. Exp. Ther. 1992; 261:470-475.
Garcia-Estañ J, Roman RJ, Garancis J, Lianos E. Effect of complement depletion on glomerular eicosanoid synthesis and renal hemodynamics in nephrotoxic serum nephritis. J. Lab. Clin. Med. 1989; 114:389-393.
Lombard JH, Roman RJ. Effect of hemorrhage upon skeletal muscle perfusion assessed via laser-Doppler flowmetry in spontaneously hypertensive rats. Am. J. Physiol. 259 (Heart Circ. Physiol. 28). 1990; H860-H865.
Wang J, Roman RJ, Falck JR, de la Cruz L, Lombard JH Effect of High Salt Diet on Cytochrome P450-4A hydroxylase Expression and Active Tone in Mesenteric Resistance Arteries Am J Physiol. 2005; 288:H1557-H1565
Wang J, Roman RJ, Falck JR, de la Cruz L, Lombard JH. Effect of High Salt Diet on Cytochrome P450-4A hydroxylase Expression and Active Tone in Mesenteric Resistance Arteries. Am J Physiol. 2005; 288:H1557-H1565.
Fenoy FJ, Roman RJ. Effect of kinin antagonists on the papillary blood flow and renal excretory responses to volume expansion. Am. J. Physiol. 1992; 263 (Reg. Integ. Comp. Physiol. 32):R1136-R1140.
Wilson TW, Alonso-Galicia M, Roman RJ. Effect of lipid lowering agents on arterial pressure and renal function in Dahl Salt-sensitive rats. Hypertension. 1998; 31:225-231.
Abe M, O’Connor P, Kaldunski M, Liang M, Roman RJ and Cowley AW Jr Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb Am J Physiol. 2006; 291:F350-7
Abe M, O’Connor P, Kaldunski M, Liang M, Roman RJ and Cowley AW Jr. Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb. Am J Physiol. 2006; 291:F350-7.
Bonventre JV, Roman, RJ, Lechene CP. Effect of urea concentration of pelvic fluid on renal concentrating ability. Am. J. Physiol. 239 (Renal Fluid Electrolyte Physiol. 8). 1980; F609-F618.
Ma Y-, Harder DR, Clark JE, Roman RJ. Effects of 12-hydroxeicosatetraenoic acid (12-HETE) on isolated dog renal arcuate arteries. Am. J. Physiol. 1991; 261 (Heart Circ. Physiol. 30):H451-H456.
Zou A-P, Ma Y-H, Ortiz de Montellano PR, Clark JE, Masters BS, Roman RJ. Effects of 17-ODYA, a suicide-substrate inhibitor of P450 fatty acid w-hydroxylase on renal function of rats. J. Pharmacol. Exp. Therap. 1994; 268:474-481.
Yu M, Lopez B, Santos EA, Falck JR, Roman RJ Effects of 20-HETE on Na-K-ATPase activity in the thick ascending loop of Henle Am J Physiol. 2007; 292:R2400-R2405
Yu M, Lopez B, Santos EA, Falck JR, Roman RJ. Effects of 20-HETE on Na-K-ATPase activity in the thick ascending loop of Henle. Am J Physiol. 2007; 292:R2400-R2405.
Yu M, Cambj-Sapunar, L, Kehl F, Maier KG, Takeuchi K, Miyata N, Ishimoto T, Reddy M, Falck JR, Gebremendhin D, Harder DR, Roman RJ Effects of a 20-HETE antagonist and agonists on cerebral vascular tone Eur J of Pharmacol. 2004; 486297-306
Yu M, Cambj-Sapunar, L, Kehl F, Maier KG, Takeuchi K, Miyata N, Ishimoto T, Reddy M, Falck JR, Gebremendhin D, Harder DR, Roman RJ. Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J of Pharmacol. 2004; 486297-306.
Williams JM, Zhang J, North P, Lacy S, Yakes M, Dahly-Veron AD, Roman RJ. Effects of a selective metalloprotease inhibitor on hypertension and diabetic nephropathy. Am J Physiology Renal Physiol 2011; 300: F983-F998
Ito O, Omata K, Ito S, Roman. Effects of angiotensin converting enzyme inhibitors on the renal P450 metabolism of arachidonic acid. Am. J. Physiol. 2001; 280:R822-R830.
Fenoy FJ, Milicic I, Smith RD, Wong P, Timmermans PBMWM, Roman RJ. Effects of DuP 753 on renal function of normotensive and spontaneously hypertensive rats. J. Am. Soc. Hypertens. 1991; 4:321s-326s.
St. Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu SL, Jacobs H, Roman RJ, Stec DE, Wang JM, Ried I, Kurtz TW. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. J. Clin. Invest. 1996; 97:522-527.
Fenoy F, Roman RJ Effects of volume expansion on papillary blood flow and sodium excretion. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol. 29). 1991; F813-F822.
Michalkiewicz M, Michalkiewicz T, Guertz AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM and Cowley AW Jr Efficient rat production by a lentiviral vector Am J Physiol. 2007; 293:H881-H894
Michalkiewicz M, Michalkiewicz T, Guertz AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM and Cowley AW Jr. Efficient rat production by a lentiviral vector. Am J Physiol. 2007; 293:H881-H894.
Lombard JH, Bizub DM, Liu Y, Fredricks KT, Roman RJ, Rusch NJ. Electrical and Mechanical Response of rat middle cerebral arteries to reduced PO2 and prostacyclin. Am J. Physiol. 1999; 276:H509-H516.
Hoagland KM, Flasch AK, Dahly-Vernon AJ, dos Santos EA, Knepper MA, Roman RJ Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys Hypertension. 2004; 43:860-5
Hoagland KM, Flasch AK, Dahly-Vernon AJ, dos Santos EA, Knepper MA, Roman RJ. Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys. Hypertension. 2004; 43:860-5.
Dunn KM, Renic M, Flasch AK, Harder DR, Falck J, Roman RJ Elevated production of 20-HETE in the cerebral vasculature enhances severity of ischemic stroke in spontaneously hypertensive rats Am J Physiol. Heart Circ Phys. 2008; 295(6): 2455-2465
Dunn KM, Renic M, Flasch AK, Harder DR, Falck J, Roman RJ. Elevated production of 20-HETE in the cerebral vasculature enhances severity of ischemic stroke in spontaneously hypertensive rats. Am J Physiol. Heart Circ Phys. 2008; 295(6): 2455-2465.
Imig JD, Falck JR, Roman RJ. Elevated renovascular tone in young spontaneously hypertensive rats: Role of cytochrome P450. Hypertension. 1993; 22:357-364.
Williams JM, Sarkis A, Lopez B, Ryan RP, Flasch AK and Roman RJ Elevations in renal interstitial hydrostatic pressure and 20-HETE contribute to pressure natriuresis Hypertension. 2007; 48: 1-8
Williams JM, Sarkis A, Lopez B, Ryan RP, Flasch AK and Roman RJ. Elevations in renal interstitial hydrostatic pressure and 20-HETE contribute to pressure natriuresis. Hypertension. 2007; 48: 1-8.
Zou, A-P, Imig JD, Ortiz de Montellano PR, Sui Z, Falck JR, Roman RJ. Endogenous P450 metabolites of arachidonic acid modulate tubuloglomerular feedback. Am. J. Physiol. 1994; 267 (Renal Fluid and Electrolyte Physiol. 35):F934-F941.
Harder DR, Roman RJ Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus Circ Res. 2006; 98:866-7
Harder DR, Roman RJ. Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. Circ Res. 2006; 98:866-7.
Cao S, Wang LC, Kwansa H, Roman RJ, Harder DR, Koehler RC Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion Am J Physiol Regul Integr Comp Physiol. 2009; 296(5): R1412-R1418
Cao S, Wang LC, Kwansa H, Roman RJ, Harder DR, Koehler RC. Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion. Am J Physiol Regul Integr Comp Physiol. 2009; 296(5): R1412-R1418.
Okamoto H, Roman RJ, Kampine JP, Hudetz AG. Endotoxin augments cerebral hyperemic response to halothane by inducing nitric oxide synthase and cyclooxygenase. Anesth and Analg. 2000; 91:896-903.
Roman RJ, Hatchell Ml. Energy dispersive X-ray microanalysis of aqueous biologic samples on bulk supports. J. Electron Microsc. Techniques 1984; 1:141-150.
Roman RJ, andHatchell M. Energy-dispersive X-ray microanalysis of aqueous biologic samples on bulk supports. Edax Editor 1984; 14:30-34.
Roman RJ, Kaldunski ML. Enhanced chloride reabsorption in the loop of Henle in Dahl salt-sensitive rats. Hypertension. 1991;17:1018-1024.
Gebremedhin D, Fenoy FJ, Harder DR, Roman RJ Enhanced myogenic response in the renal vasculature of spontaneously hypertensive rats. Hypertension 1990; 16:648-654.
Liu X, Li C, Gebremedhin D, Hwang SH, Hammock BD, Falck Jr, Roman RJ, Harder DR, Koehler RC. Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. Am J Physiol 2011; 301:H373-383.
Liu X, Li C, Gebremedhin D, Hwang SH, BD, Falck JR, Roman RJ, Harder DR, Koehler RC. Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. Am. J Physiol. 2011; H373-383
Lombard JH, Frisbee JC, Roman RJ, Falck JR Evaluation of cytochrome P450-4A omega-hydroxylase and 20-hydroxyeicosatetraenoic acid as an O2 sensing mechanism in the microcirculation Methods Enzymol. 2004; 381:140-65
Lombard JH, Frisbee JC, Roman RJ, Falck JR. Evaluation of cytochrome P450-4A omega-hydroxylase and 20-hydroxyeicosatetraenoic acid as an O2 sensing mechanism in the microcirculation. Methods Enzymol. 2004; 381:140-65.
Kauker ML, Zawada ED, Kauker LM, Roman RJ, Rosivall L. Evidence for distal tubular inhibition of calcium efflux by nisoldipine in the SHR rat. Experimental Nephrology. 1997; 5:384-389.
Roman RJ, Renic M, Dunn KD, Takeuchi K and Hacein-Bey L Evidence that 20-HETE Contributes to the Development of Acute and Delayed Cerebral Vasospasm Neuroradiol Res. 2006; 28:38-749
Roman RJ, Renic M, Dunn KD, Takeuchi K and Hacein-Bey L. Evidence that 20-HETE Contributes to the Development of Acute and Delayed Cerebral Vasospasm. Neuroradiol Res. 2006; 28:38-749.
Guo AM, Sheng J, Scicli GM, Arbab AS, Lehman NL, Edwards PA, Falck JR, Roman RJ, Scicli AG Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo J Pharmacol Exp Ther. 2008; 327(1): 10-19
Guo AM, Sheng J, Scicli GM, Arbab AS, Lehman NL, Edwards PA, Falck JR, Roman RJ, Scicli AG. Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo. J Pharmacol Exp Ther. 2008; 327(1): 10-19.
Wang J, Maier KG, Roman RJ, De La Cruz L, Zhu J, Henderson L, Lombard JH Expression of Cytochrome P450-4A Isoforms in the Rat Cremaster Muscle Microcirculation Microcirculation. 2004; 11:89-96
Wang J, Maier KG, Roman RJ, De La Cruz L, Zhu J, Henderson L, Lombard JH. Expression of Cytochrome P450-4A Isoforms in the Rat Cremaster Muscle Microcirculation. Microcirculation. 2004; 11:89-96.
Amin RP, Vickers AE, Sistare F, Thompson K, Roman RJ, Lawton M, Kramer J, Hamadeh HK, Collins J, Grissom S, Bennett L, Tucker CJ, Wilde S, Oreffo V, Davis J, Curtiss S, Naciff JM, Cunningham M, Tennant R, Stevens J, Car B, Bertram TA, Afshari CA Expression Profiles Associated With Nephrotoxicity Enviromental Health Perspectives. 2004; 112:465-479
Amin RP, Vickers AE, Sistare F, Thompson K, Roman RJ, Lawton M, Kramer J, Hamadeh HK, Collins J, Grissom S, Bennett L, Tucker CJ, Wilde S, Oreffo V, Davis J, Curtiss S, Naciff JM, Cunningham M, Tennant R, Stevens J, Car B, Bertram TA, Afshari CA. Expression Profiles Associated With Nephrotoxicity. Enviromental Health Perspectives. 2004; 112:465-479.
Vera T, Taylor M, Bohman Q, Flash A,.Roman RJ, Stec DE Fenofibrate prevents the development of Angiotensin II-dependent hypertension in mice Hypertension. 2005; 45:730-735
Vera T, Taylor M, Bohman Q, Flash A,.Roman RJ, Stec DE. Fenofibrate prevents the development of Angiotensin II-dependent hypertension in mice. Hypertension. 2005; 45:730-735.
Kalkoff RK, Yorde DE, Roman RJ, Siegesmund KA, Dragen RF. Fluctuations of alpha cell calcium, potassium, and sodium during amino acid perfusion of rat pancreatic islets. Endocrinology 1987; 121:429-431.
Mroz EA, Roman, RJ, Lechene CP. Fluorescence assay for picomole quantities of ammonia Kidney Int. 1982; 21:524-527.
Maier KG, Henderson L, Narayanan J, Alonso-Galicia M, Falck JR, Roman RJ. Fluroescent HPLC assay for 20-HETE and other P450 metabolites of arachidonic acid. Am J Physiol Heart Circ Physiol. 2000; 279:H863 71.
Imig JD, Zou AP, Stec DE, Harder DR, . Falck JR, Roman RJ. Formation and action of 20-HETE on in rat renal arterioles. Am. J. Physiol. 1996; 270 (Regulatory and Integrative Physiol. 39):R217-R227.
Harder DR, Gehemendhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB, Roman RJ. Formation and action of a P450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am. J. Physiol. 1994; 266 (Heart and Circulatory Physiology 35):H2098-H2107.
Masters BSS, Clark JE, Roman LJ, Nishimoto M, McCabe TJ, Ortiz de Montellano PR, Plopper CG, Ma Y-H, Harder DR, Roman RJ. Functional aspects of eicosanoid hydroxylation by lung and kidney cytochromes P450. Expression of cDNAs in mammalian cells and E. coli. J Lipid Mediators. 1993; 6:353-360.
Harder DR, Alkayed N, Lange AR, Roman RJ. Functional hyperemia in the brain: role for astrocyte derived vasodilatory metabolites. Stroke. 1998; 29:229-234.
Stec DE, Roman RJ, Falsch A and Rieder MJ Functional polymorphisms in human CYP4F2 decrease 20-HETE production Physiologic Genomics. 2007; 30:74-81
Stec DE, Roman RJ, Falsch A and Rieder MJ. Functional polymorphisms in human CYP4F2 decrease 20-HETE production. Physiologic Genomics. 2007; 30:74-81.
Roman RJ Gene Therapy and Heme Oxygenase Coming of Age Hypertension. 2004; 43: 1173-1174, 2004
Roman RJ. Gene Therapy and Heme Oxygenase Coming of Age. Hypertension. 2004; 43: 1173-1174, 2004.
St. Lezin M Pravenec, Wong A, Wang JM , Merriouns Newton TS, Stec DE, Roman RJ, Lau D, Morris RC Jr, Kurtz TW. Genetic contamination of Dahl SS/Jr rats: Impact on studies of salt sensitive hypertension. Hypertension. 1994; 23:786-790.
Fenoy FJ, St. Lezin E, Kurtz TW, Roman RJ Genetic heterogeneity and differences in glomerular hemodynamics between inbred colonies of Munich-Wistar rats. J. Am. Soc. Nephrol. 1992; 3:66-72.
Cowley AW, Jr, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, Schork NJ, Dumas P, Jacob HJ. Genetically defined risk of salt-sensitivity within a population of F2 rats from a Brown Norway and Dahl S derived intercross. Physiol. Genomics. 2000; 2:107-115.
Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW Jr Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats Physiol Genomics. 2003; 11:243-257
Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW Jr. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics. 2003; 11:243-257.
Kotchen TA, Piering AW, Cowley Jr AW, Grim CE , Gaudet D, Hamet P, Kaldunski ML, Kotchen JM, Roman RJ. Glomerular hyperfiltration in hypertensive African Americans. Hypertension. 2000; 35:822 6.
Krieger JE, Cowley AW Jr, Roman RJ. Hemodynamics, fluid volume and hormonal responses to chronic high salt intake in dogs. Am. J. Physiol. 257 (Heart Circ. Physiol. 26). 1989; H1402-H1412.
Takeuchi K, Miyata N, Renic M, Harder DR, and Roman RJ Hemogloblin, NO and 20-HETE interactions in medicating cerebral vasoconstriction following SAH Am J Physiol. 2006; 290:R84-R89
Takeuchi K, Miyata N, Renic M, Harder DR, and Roman RJ. Hemogloblin, NO and 20-HETE interactions in medicating cerebral vasoconstriction following SAH. Am J Physiol. 2006; 290:R84-R89.
Fu Y, Roman RJ, Lu D, Zhu X, Liu R. High salt intake-induced TGF suppression is partially mediated by primary cilia on the macula densa Hypertension. 2010; 55: e159
Pei J, Yan PK, Chen JX, Zhu BY, Lei XY, Yin WD, Liao DF. High-density lipoprotein 3 inhibits oxidized low- density lipoprotein-induced apoptosis via promoting cheolesterol efflux in RAW264.7 cells Acta Pharmacological Sin. 2006 27(2):151-7.
Guo M, Roman RJ, Falck JR, Edwards PA, Scicli AG. Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl) formamidine], a selective inhibitor of CYP4A. J Pharmacol Exp Ther. 2005; 31:526-33.
Guo M, Roman RJ, Falck JR, Edwards PA, Scicli AG. Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl) formamidine], a selective inhibitor of CYP4A J Pharmacol Exp Ther. 2005; 31:526-33
Messer-Letienne I, Bernard N, Roman RJ, Sassard J, Benzoni D. Hydroxy-eicosatetraenoic acids contribute to the renal alterations in the Lyon hypertensive rat. Eur. J. Pharmacol. 1999; 378:291-297.
Grim CE, Cowley AW Jr, Hamet P, Gaudet D, Kaldunski ML, Kotchen JM Krishnaswami S, Pausova Z, Roman RJ, Tremblay J, Kotchen TA Hyperaldosteronism and hypertension. Ethnic differences Hypertension. 2005; 45:766-772
Grim CE, Cowley AW Jr, Hamet P, Gaudet D, Kaldunski ML, Kotchen JM Krishnaswami S, Pausova Z, Roman RJ, Tremblay J, Kotchen TA. Hyperaldosteronism and hypertension. Ethnic differences. Hypertension. 2005; 45:766-772.
Chen JX, Meyrick BO Hypoxia Increases Hsp90 Binding to eNOS via a PI3Kinase-Akt Pathway in Porcine Coronary Artery Endothelium Lab Invest. 2004; 84(2):182-190.
Zhu D, Birks EK, Dawson CA, Patel M, Falck JR, Presberg K, Roman RJ, Jacobs ER. Hypoxic pulmonary vasoconstriction is modified by P 450 metabolites Am J Physiol Heart Circ Physiol. 2000; 279:H1526 H1533.
Harder DR, Narayanan J, Birks E, Liard JF, Imig J, Lombard JL, Lange A, Roman RJ. Identification of a putative oxygen sensor. Circ. Res. 1996; 79:54-61.
Lopez B, Ryan RP, Moreno C, Sarkis A, Lazar J, Proovost AP, Jacob HJ, Roman RJ Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in Fawn Hooded-Hypertensive rats Am J Physiol 290. 2006; F1213-F1218
Lopez B, Ryan RP, Moreno C, Sarkis A, Lazar J, Proovost AP, Jacob HJ, Roman RJ. Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in Fawn Hooded-Hypertensive rats. Am J Physiol 290. 2006; F1213-F1218.
VanDokkum RPE, Provoost AP, Jacob HJ, Roman RJ. Impaired autoregulation of renal blood flow in the Fawn-Hooded rat. Am. J. Physiol. 1999; 276:R189-R196.
VanDokkum, RPE, Sun CW, Jacobs HJ, Roman RJ. Impaired renal myogenic responses in the Fawn-Hooded rat. Am. J. Physiol. 1999; 276:R855-R863.
Frisbee JC, Roman RJ, Falck JR, Linderman JR, Lombard JH. Impairment of flow induced dilation of skeletal muscle arterioles with elevated oxygen in normotensive andhypertensive rats. Microvasc Res. 2000; 60:37-48.
Seki T, Ishimoto T, Sakurai T, Yasuda Y, Taniguchi K, Doi M, Sato M, Roman RJ, Miyata N Increased excretion of urinary 20-HETE in rats with cyclosporine-induced nephrotoxicity J Pharmacol Sci. 2005; 97:132-137
Seki T, Ishimoto T, Sakurai T, Yasuda Y, Taniguchi K, Doi M, Sato M, Roman RJ, Miyata N. Increased excretion of urinary 20-HETE in rats with cyclosporine-induced nephrotoxicity. J Pharmacol Sci. 2005; 97:132-137.
Makino A, Skeleton MM, Zou A-P, Roman RJ, Cowley AW Jr. Increased renal medullary oxidative stress produces hypertension. Hypertension. 2002; 39:667-672.
Alonso-Galicia M, Frohlich B, Roman RJ. Induction of P4504A activity normalizes pressure-natriuresis and prevents hypertension in Dahl S rats. Hypertension. 1998; 31:232-236.
Lu G, Mazet B, Sun C, Qian X, Johnson CP, Adams MB, Roman RJ, Sarna SK. Inflammatory modulation of calcium-activated potassium channels in canine colonic smooth muscle cells. Gastroenterology. 1999; 116:884-892.
Mattson DL, Raff H, Roman RJ. Influence of angiotensin II on pressure-natriuresis and renal hemodynamics in volume-expanded rats. Am. J. Physiol. 260 (Reg. Integ. Comp. Physiol. 29). 1991; R1200-R1209.
Santos EA, Annette Dahly A, Hoagland KM, and Roman RJ Influence of CYP metabolites of arachidonic acid on pressure natriuresis Am J Physiol. 2004; 287:R58-R68
Santos EA, Annette Dahly A, Hoagland KM, and Roman RJ. Influence of CYP metabolites of arachidonic acid on pressure natriuresis. Am J Physiol. 2004; 287:R58-R68.
Mattson DL, Kunert MP, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ and Cowley AW Jr Influence of diet and genetics on hypertension and renal disease in Dahl Salt-sensitive rats Physiol Genomics. 16:194-203, 2004
Mattson DL, Kunert MP, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ and Cowley AW Jr. Influence of diet and genetics on hypertension and renal disease in Dahl Salt-sensitive rats. Physiol Genomics. 16:194-203, 2004.
Roman RJ, Kaldunski ML, Scicli AG, Carretero OA . Influence of kinins and angiotensin II on the regulation of papillary blood flow. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24):1988; F690-F698.
Roman RJ, Lianos E. Influence of renal prostaglandins on papillary blood flow, renal interstitial pressure and the pressure-natriuretic response. Hypertension. 1990; 15:29-35.
Roman RJ, Kaldunski ML, Mattson DL, Mistry M, Nasjletti A. Influence of renal prostanoids on renal function of Doca-Salt hypertensive rats. Hypertension 1988; 12:287-294.
Roman RJ, Zou A-P. Influence of the renal medullary circulation on the control of sodium excretion. Am. J. Physiol. 1993; 265 (Reg. Int. Comp. Physiol. 34):R963-R973.
Alonso-Galicia, M, Drummond HA, Catipally KR, Falck JR, Roman RJ. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Hypertension. 1997; 29 (2):320-326.
Alonso-Galicia M, Sun CW, Falck JR, Harder DR Roman RJ. Inhibition of 20-HETE production mediates the cGmp-independent effects of nitric oxide in the renal circulation. Am J. Physiol. 1998;275 (Renal Physiol. 44) F370-F378.
Alkayed NJ, Birks EK, Roman RJ, Harder DR. Inhibition of P450 epoxygenase decreases cerebral blood flow. Am. J. Physiol. 1996; (Heart Circ. Physiol. 40) 271:H1541-H1546.
Stec DE, Mattson DL, Roman RJ. Inhibition of renal outer medullary 20-HETE production produces hypertension in Lewis Rats. Hypertension. 1997; 29(2):315-320.
Roman RJ, Kauker ML, Terragno NA, Wong PY-K. Inhibition of renal prostaglandin synthesis and metabolism by indomethacin in rats. Proc. Soc. Exp. Biol. Med. 1978; 159:165-170.
Zou A-P, Imig JD, Kaldunski M, Ortiz de Montellano PR, Sui Z, Roman RJ. Inhibition of renal vascular production of 20-hydroxyeicostetraenoic acid impairs autoregulation of renal blood flow. Am. J. Physiol. 1994; 266 (Renal Fluid and Electrolyte Physiol. 35): F275-F282.
Kauser K, Clark JE, Ma YH, Montellano P Ortiz, Masters BSS, Harder DR, Roman RJ. Inhibitors of arachidonic acid metabolism attenuate the myogenic response in dog renal arcuate arteries. Circ. Res. 1991; 68:1154-1163.
Chen P, Guo M, Wygle D, Edwards P, Falck JR, Roman RJ and Scicli AG Inhibitors of Cytochrome P450 4A suppress angiogenic responses Am J Pathol. 2005; 166:615-624
Chen P, Guo M, Wygle D, Edwards P, Falck JR, Roman RJ and Scicli AG. Inhibitors of Cytochrome P450 4A suppress angiogenic responses. Am J Pathol. 2005; 166:615-624.
Imig J, Zou A-P, Ortiz de Montellano PR, Sui Z, Roman RJ. Inhibitors of cytochrome P450 alter afferent arteriolar responses to elevations in pressure. Am. J. Physiol. 1994; 266 (Heart Circ. Physiol. 35):H1879-H1885.
Nobrega MA, Fleming S, Roman RJ1, Shiozawa M, Schlick N, Lazar J and Jacob HJ Initial Characterization of a Rat Model of Diabetic Nephropathy Diabetes. 2004; 53:735-742
Nobrega MA, Fleming S, Roman RJ1, Shiozawa M, Schlick N, Lazar J and Jacob HJ. Initial Characterization of a Rat Model of Diabetic Nephropathy. Diabetes. 2004; 53:735-742.
Frisbee JC, Maier KG, Falck JR, Roman RJ, and Lombard JH. Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries. Am. J. Physiol. 2002; 283: R309-R319.
Liu X, Li C, Falck JR, Roman RJ, Harder DR, Koehler RC Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex Am J Physiol Heart Circ Physiol. 2008; 295(2): H619-31
Liu X, Li C, Falck JR, Roman RJ, Harder DR, Koehler RC. Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. Am J Physiol Heart Circ Physiol. 2008; 295(2): H619-31.
Okamoto H, Meng W, Ma J, Ayata C, Roman RJ, Bosnjak Z, Huang P, Moskowitz MA, Hudetz AG. Isoflurane-induced cerebral hyperremia in neuronal nitric oxide synthase gene deficient mice. Anesthesiology. 1997; 86:875-884.
Kehl F, Shen H, Moreno C, Farber NE, Roman RJ, Kampine JP and Hudetz AG. Isoflurane-induced hyperemia is partially mediated by nitric oxide and epoxyeicosatrienoic acids in mice in vivo. Anesthesiology. 2002; 97:1528-1533.
Roman RJ, Smits C. Laser Doppler determination of papillary blood flow in young and adult rats. Am. J. Physiol. 251 (Renal Fluid Electrolyte Physiol. 20). 1986; F115-F124.
Bylund J, Harder AG, Maier KM, Roman RJ and Harder DR. Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6. Archiv Biochem Biophys 2003; 412:34-41.
Yang Y, Dahly-Vernon AJ, Blomme EA, Lai-Zhang J, Kempf DJ, Marsh KC, Harrington YA, Nye SH, Evans DL, Roman RJ, Jacob HJ, Waring JF Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats Vet J. 2010; 185: 75-82
Yang Y, Dahly-Vernon AJ, Blomme EA, Lai-Zhang J, Kempf DJ, Marsh KC, Harrington YA, Nye SH, Evans DL, Roman RJ, Jacob HJ, Waring JF. Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats. Vet J. 2010; 185: 75-82.
Ito O, Alonso-Galicia M, Hopp KA, Roman RJ. Localization of cytochrome P4504A isoforms along the rat nephron. Am J. Physiol. 1998; 274 (Renal Physiol. 43):F395-F404.
Jiang J, Roman RJ. Lovastatin prevents the development of hypertension in Spontaneously Hypertensive rats. Hypertension. 1997; 30:968-974.
Jiang J, Roman RJ. Lovastatin reduces renal vascular reactivity in spontaneously hypertensive rats. Am. J. Hypertension. 1998; 11:1222-1231.
Stadnicka A, Contney SJ, Moreno C, Weihrauch D, Bosnjak ZJ, Roman RJ and Stekiel TA Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway and chromosome 13 substituted consomic rat strains: role of large conductance Ca2+ and valtage activated potassium channels J Pharm Exp Therap. 2009; 330:727-735
Stadnicka A, Contney SJ, Moreno C, Weihrauch D, Bosnjak ZJ, Roman RJ and Stekiel TA. Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway and chromosome 13 substituted consomic rat strains: role of large conductance Ca2+ and valtage activated potassium channels. J Pharm Exp Therap. 2009; 330:727-735.
Osborn JL, Roman RJ, Harland RW. Mechanisms of antinatriuresis during low frequency renal nerve stimulation in anesthetized dogs. Am. J. Physiol. 249 (Reg. Integ. Comp. Physiol. 18). 1985;R360-367.
Roman RJ, Lechene CP. Meclofenamate and urine concentration with and without exposure of the renal papilla. Am. J. Physiol. 240 (Renal Fluid Electrolyte Physiol. 9). 1981; F423-F429.
Bresnahan BA, Roman RJ, Bagchus W, Lianos EA. Mesangial cell immune injury: Effects of thromboxane receptor antagonism. J. Am. Soc. Nephrology. 1991;1:1041-1047.
Breshnahan BA, Wu S, Fenoy FJ, Roman RJ, Lianos EA. Mesangial cell immune injury: Hemodynamic role of leukocyte and platelet-derived eicosanoids. J. Clin. Invest. 1992; 90:2304-2312.
Park SW, Shen X, Tien L-T, Roman RJ, Ma T. Methamphetamine-induced changes in the striatal dopamine pathway in mu-opioid receptor knockout mice J Biomed Sci 2011; 18:83-87.
Lombard JH, Greene AS, Hudetz AG, Roman RJ, Tonellato PJ. Microvascular bood flow and tissue P02 in rats with chronic reduced renal mass hypertension. Am. J. Physiol. 2006; Nov;279 (5): H2295-302.
Lombard, JH, Frisbee JC, Greene AS, Hudetz AG, Roman RJ, Tonellato PJ. Microvascular flow and tissue PO2 in skeletal muscle of chronic reduced renal mass hypertensive rats. Am. J. Physiol Heart Circ Physiol. 2000; 279:H2295-H2302.
Raffai G, Wang J, Roman RJ, Anjaiah S, Weinberg B, Falck JR, Lombard JH Modulation by cytochrome P450-4A ω-hydroxylase enzymes of adrenergic vasoconstriction and response to reduced PO₂ in mesenteric resistance arteries of Dahl salt-sensitive rats Microcirculation. 2010; 17:525-35
Raffai G, Wang J, Roman RJ, Anjaiah S, Weinberg B, Falck JR, Lombard JH. Modulation by cytochrome P450-4A ω-hydroxylase enzymes of adrenergic vasoconstriction and response to reduced PO₂ in mesenteric resistance arteries of Dahl salt-sensitive rats. Microcirculation. 2010; 17:525-35.
Rajapakse NW, Roman RJ, Falck JR, Oliver JJ, Roger G Evans Modulation of V1-receptor-mediated vasoconstriction by epoxyeicosatrienoic acids Am J Physiol. 2004; 287:R181-R187
Rajapakse NW, Roman RJ, Falck JR, Oliver JJ and Roger G Evans. Modulation of V1-receptor-mediated vasoconstriction by epoxyeicosatrienoic acids. Am J Physiol. 2004; 287:R181-R187.
Wang J, Schmidt JR, Roman RJ, Anjaiah S, Falck JR, Lombard JH Modulation of vascular O2 responses by cytochrome 450-4A omega-hydroxylase metabolites in Dahl salt-sensitive rats Microcirculation. 2009; 16(4): 345-354
Wang J, Schmidt JR, Roman RJ, Anjaiah S, Falck JR, Lombard JH. Modulation of vascular O2 responses by cytochrome 450-4A omega-hydroxylase metabolites in Dahl salt-sensitive rats. Microcirculation. 2009; 16(4): 345-354.
Wang J, Schmidt JR, Roman RJ, Anjaiah S, Falck JR, Lombard JH Modulation of vascular O2 responses by cytochrome P4504A w-hydroxylase metabolites in Dahl salt-sensitive rats Microcirculation J. 2009; 16(4): 345-354
Wang J, Schmidt JR, Roman RJ, Anjaiah S, Falck JR, Lombard JH. Modulation of vascular O2 responses by cytochrome P4504A w-hydroxylase metabolites in Dahl salt-sensitive rats. Microcirculation J. 2009; 16(4): 345-354.
Alkayed NJ, J. Narayanan J, Gebremendhin D, Medhora M, Roman RJ, Harder DR. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke. 1996 27:971-979.
Harder DR, Roman RJ, Gebremedhin D. Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes. Acta Physiol Scand. 2000; 68:543 9.
Renic M, Kumar S, Gebremedhin D, Florence MA, Gerges NZ, Falck JR, Harder DR, Roman RJ Molecular mechanisms of the myogenic response and TGF in autoregulation of RBF Current Vasc Pharmacol 00:000-000, 2012 (in press)
Moreno C, Kaldunski ML, Wang T, Roman RJ, Greene AS, Lazar J, Jacob HR, Cowley AW Jr Multuiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat Physiologic Genomics. 2007; 31:228-235
Moreno C, Kaldunski ML, Wang T, Roman RJ, Greene AS, Lazar J, Jacob HR, Cowley AW Jr. Multuiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. Physiologic Genomics. 2007; 31:228-235.
Chen JX, Zeng H, Qin-Hui Tuo, Heidi Yu, Meyrick B, Judy Aschner. NADPH oxidase mediates myocardial Akt, ERK1/2 activation and angiogenesis after hypoxia/reperfusion. Am J Physiol Heart Circ Physiol, 2007; 292:H1664-1674.
Moreno, C, Williams JM, Lu L, Liang M, Lazar J, Jacob HJ, Cowley AW Jr, Roman, RJ Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl S-13 congenic strains Am J Physiol. 00: H000-H000, Jan 21,2011
Garcia-Estañ J, Takezawa K, Roman RJ. Natriuretic effect of atriopeptin III in rats with papillary necrosis. Am. J. Physiol. 257 (Renal Fluid Electrolyte Physiol. 26). 1989; F859-F865.
Roman RJ, Sias F. Network computer analysis of the human kidney. Math. Modelling. 1986; 7:1045-1069.
Okamoto H, Hudetz AG, Roman RJ, Bosnjak ZJ, Kampine JP. Neuronal NOS-derived NO plays a permissive role in the cerebral blood flow response to hypercapnia. Am. J. Physiol. 1996; (Heart Circ Physiol 40) 271:H1541-H1546.
Yang Z-J, Carter EL, Kibler KK, Kwansa,H Crafa,DA, Martin LJ, Roman, RJ, Harder,DR Koehler RC. Neuroprotective effect of a 20-HETE synthesis inhibitor in selectively vulnerable putamen after neonatal hypoxia-ischemia. Am J Physiol 2012. (In press) 000:H000-H000.
Yu M, McAndrew RP, Al-Saghir R, Maier KG, Medhora M, Roman RJ, and Jacobs ER. Nitric oxide contributes to 20-HETE induced relaxation of pulmonary arteries. J. Appl. Physiol. 2002; 93:1391-1399.
Imig JD, Roman RJ. Nitric oxide modulates renal vascular tone in renal preglomerular arterioles. Hypertension. 1992; 19:770-774.
Sun C-W, Alonso-Galicia M, Taheri MR, Falck JR, Harder DR, Roman RJ. Nitric Oxide-20-HETE Interaction in the Regulation of K+ Channel Activity and Vascular Tone in Renal Arterioles. Circ. Res. 1998; 83:1069-1079.
Taylor NE, Maier KG, Roman RJ, Cowley AW Jr NO synthase uncoupling in the kidney of Dahl S rats-role of dihydrobiopterin Hypertension. 2006; 48: 1066-71
Taylor NE, Maier KG, Roman RJ, Cowley AW Jr. NO synthase uncoupling in the kidney of Dahl S rats-role of dihydrobiopterin. Hypertension. 2006; 48: 1066-71.
Fenoy FJ, Kauker ML, Milicic I, Roman RJ. Normalization of pressure-natriuresis by nisoldipine in spontaneously hypertensive rats. Hypertension. 1992; 19:49-55.
Roman RJ, Alonso-Galicia M. P450 eicosanoids: A novel signaling pathway regulating renal function. NIPS. 1999; 14:238-241.
Roman RJ, Kaldunski ML. Papillary blood flow during the development of hypertension in the spontaneously hypertensive rat. Hypertension. 1988; 11: 657-663.
Cowley AW Jr, Roman RJ, Krieger JE. Pathways linking renal excretion, arterial pressure with vascular structure and function. Clin. Exp. Pharmacol. Physiol. 1991; 18:21-27.
Stekiel, TA, Contney SJ, Roman RJ, Weber CA, Stadnicka A, Bosnjak ZJ, Greene AS, Moreno C. Pharmacogenic strain differences in cardiovascular sensitivity to propofol. Anesthesiology 2011;115:1-9.
Yanes LL, Lima R, Moulana M, Romero DG, Yuan K, Ryan MJ, Baker R, Zhang H, Fan F, Davis DD, Roman RJ, Reckelhoff JF Postmenopausal hypertension: role of 20-HETE. Am J Physiol. 2011;300:R1543-R1548.
Roman RJ Pressure diuresis mechanism in the control of renal function and arterial pressure. Fed. Proc. 1986; 45:2878-2884.
Sanchez-Ferrer C, Roman RJ Roman, Harder DR. Pressure-dependent contraction of rat juxtamedullary afferent arterioles. Circ. Res. 1989; 64: 790-798.
Roman RJ, Lombard JH, Cowley AW Jr, Garcia-Estan J. Pressure-diuresis in volume-expanded rats: Cortical and medullary hemodynamics Hypertension. 1988; 12: 168-176.
Roman RJ Pressure-diuresis in volume-expanded rats: Tubular reabsorp¬tion in superficial and deep nephrons. Hypertension. 1988; 12:177-183.
Harder DR, Roman RJ. Pressure-induced activation of cerebral and renal arteries. In: Endothelial Regulation of Vascular Tone. Edited by U. Ryan and G. Rubanyi. New York: Marcel Dekker, 1991, pp. 265-271
Roman RJ, Kaldunski M. Pressure-natriuresis and cortical and papillary blood flow in inbred Dahl rats. Am. J. Physiol. 1991; 261 (Reg. Integ. Comp. Physiol. 30):R595-R602.
Narayanan J, Imig M, Roman RJ, Harder DR. Pressurization of isolated renal arteries increases inositol triphosphate and diacylglycerol concentrations. Am. J. Physiol. 266. 1994; (Heart Circ. Physiol. 35):H1840-H1845.
Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, Narayanan J, Falck JR, Okamoto H, Roman RJ, Nithipatikom K, Campbell WB, Harder DR. Production of 20 HETE and its role in autoregulation of cerebral blood flow. Circ Res. 2000; 87: 60-65.
Roman RJ, and Lechene CP. Prostaglandin E2 and F2α reduces urea reabsorption from the rat collecting duct. Am. J. Physiol. 241 (Renal Fluid Electrolyte Physiol. 10), 1981; F53-F60.
Roman RJ, Skelton M, and Lechene C. Prostaglandin-ADH interactions on the renal handling of calcium and magnesium. J. Pharmacol. Exp. Ther. 1984; 230:295-301.
Carmines PK, Bell PD, Roman RJ, Work J, Navar LG. Prostaglandins in the sodium excretory response to altered renal arterial pressure in dogs. Am. J. Physiol. 248 (Renal Fluid Electrolyte Physiol. 17) 1985; F8-F14.
Regner KR, Zuk A, Shames BD, Van Why SK, Ryan RP, Roman RJ Protective effect of 20-HETE analogues in experimental renal ischemia-reperfusion injury Kidney Int. 2009; 75: (5)11-517
Regner KR, Zuk A, Shames BD, Van Why SK, Ryan RP, Roman RJ. Protective effect of 20-HETE analogues in experimental renal ischemia-reperfusion injury. Kidney Int. 2009; 75: (5)11-517.
Regner KR, Nilakantan V, Ryan RP, Mortensen J, White SM, Shames BD, Roman RJ. Protective effect of lifor solution in experiment renal ischemia-reperfusion injury J Surg Res. 2010;164:291-297
Regner KR, Nilakantan V, Ryan RP, Mortensen J, White SM, Shames BD, Roman RJ. Protective effect of lifor solution in experiment renal ischemia-reperfusion injury. J Surg Res. 2010;164:291-297.
Nye SH, Wittenburg AL, Evans DL, O Connor JA, Roman RJ and Jacob HJ Rat survival to anthrax lethal toxin is likely controlled by a single gene Pharmacogenomics J. 2008; 8(1): 16-22
Nye SH, Wittenburg AL, Evans DL, O Connor JA, Roman RJ and Jacob HJ. Rat survival to anthrax lethal toxin is likely controlled by a single gene. Pharmacogenomics J. 2008; 8(1): 16-22.
Ito O, Roman RJ. Regulation of 20-hydroxyeicosatetraenoic acid formation in the glomerulus of the rat. Am J Physiol. 1999; 276:R1749-R1758.
Gebroth JR, Effros RM, Roman RJ, Jacobs ER. Regulation of intracellular PH and calcium in type II pulmonary epithelial cells. Am J. Physiol. 1993; 264 (Lung and Respiration 8): L448-L457.
Frisbee JC, Roman RJ, Krishna UM, Falck JR, Lombard JH. Relative contributions of cyclooxygenase and cytochrome P-450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries. J. Vasc. Res. 2001; 38:305-314.
Maier KG, Roman RJ. Renal actions of P450 metabolites of arachidonic acid. Current Opinion in Nephrol. 10:81-87, 2001.
Roman RJ, Maier KG, Sun CW, Harder DR, Alonso-Galicia M. Renal and cardiovascular actions of 20-HETE and EETs. Clinical Exp. Pharmacol. Physiol. 2000; 27:855-865.
Stec DE, Trolliet MR, Krieger JE, Jacob HJ, Roman RJ. Renal cytochrome P4504A activity and salt-sensitivity in Spontaneously Hypertensive rats. Hypertension. 1996; 27:1329-1336.
Cowley AW Jr., Roman RJ. Renal dysfunction in essential hypertension - implications of experimental studies. Am. J. Nephrol. 1983; 3:59-72.
Roman RJ, and Kauker ML. Renal effect of prostaglandin synthetase inhibition in rats: micropuncture studies. Am. J. Physiol. 235 (Renal Fluid Electrolyte Physiol. 4). 1978; F111-F118.
Moreno C, Mistry M, and Roman RJ. Renal effects of glucagon-like peptide in rats. Eur. J. Physiol. 2002; 11:163-167.
Roman RJ, Osborn JL. Renal function and sodium balance in conscious Dahl S and R rats. Am. J. Physiol. 252 (Reg. Integ. Comp. Physiol. 21) 1987; R833-R841.
Cowley AW, Jr, Mattson D, Lu S-H, Roman RJ. Renal medulla in the development of hypertension. Hypertension. 1995; 25:663-673.
Lu S-H, Roman RJ, Mattson D, Cowley Jr AW. Renal medullary interstitial infusion of diltiazem alters sodium and water excretion in the rat. Am. J. Physiol. 1992; 263 (Reg. Integ. Comp. Physiol. 32): R1064-R1070.
Szentivany M Jr, Zou AP, Mattson DL, Soares P, Moreno C, Roman RJ and Cowley AW Jr. Renal medullary NO deficit of Dahl S rats enhances the hypertensive actions of angiotensin II. Am. J. Physiol. 2002; 283: R266-R272.
Ma Y-H, Schwartzman ML, Roman RJ. Renal metabolism of arachidonic acid in Dahl rats. Am. J. Physiol. 1994; 267 (Reg Int. Comp. Physiology 36):R579--R589.
Roman RJ, Alonso-Galicia M, Wilson TW. Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl S rats. Am. J. Hypertension. 1997; 10:63S-67S.
Roman RJ, Carter, JR, North, WC North and Kauker ML. Renal tubular site of action of fluoride in Fisher 344 rats. Anesthesiology. 1977; 46:260-264.
Roman RJ and Kauker ML. Renal tubular transport of 3H-digoxin in saline diuretic rats as evaluated by micropuncture Circ. Res. 1976; 38:185-191.
Amaral SL, Roman RJ, Greene AS. Renin gene transfer restores angiogensis and VEGF expression in Dahl S rats. Hypertension. 2001; 37:386-390.
Kramer JA, Petit S, Amin RP, Bertram TA, Car B, Cunningham M, Curtiss SW, Davis J, Lawton M, Naciff J, Oreffo V, Roman RJ, Sistare FD, Stevens J, Thompson K, Vickers AE,Wild S, and Afshari CA Report on the application of transcription profiling using selected nephrotoxicants for toxicology assessment Enviromental Health Perspectives. 2004; 112:460-464
Kramer JA, Petit S, Amin RP, Bertram TA, Car B, Cunningham M, Curtiss SW, Davis J, Lawton M, Naciff J, Oreffo V, Roman RJ, Sistare FD, Stevens J, Thompson K, Vickers AE,Wild S, and Afshari CA. Report on the application of transcription profiling using selected nephrotoxicants for toxicology assessment. Enviromental Health Perspectives. 2004 112:460-464.
Liu YP, Fredricks KT, Roman RJ, Lombard JH. Response of resistance arteries to reduced PO2 and vasodilators during hypertension and elevated salt intake. Am. J. Physiol. .1997; 273 (Heart Circ. Physiol. 42):H869-H877.
Takeuchi K, Renic M, Bohman QC, Harder DR, Miyata N and Roman RJ Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE Am J Physiol. 2005; 289:H2203-H2210
Takeuchi K, Renic M, Bohman QC, Harder DR, Miyata N and Roman RJ. Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE. Am J Physiol. 2005; 289:H2203-H2210.
Hacein-Bey L, Harder DR, Meier HT, Varelas PN, Miyata N, Lauer KK, Cusick JF, Roman RJ Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage AJNR Am J Neuroradiol. 2006; 27:1350-4
Hacein-Bey L, Harder DR, Meier HT, Varelas PN, Miyata N, Lauer KK, Cusick JF, Roman RJ. Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2006; 27:1350-4.
Stekiel TA, J Contney S, Bosnjak ZJ, Kampine JP, Roman RJ, Stekiel WJ Reversal of minimum alveolar concentrations of volatile anesthetics by chromosomal substitution Anesthesiology. 2004; 101: 796-798
Stekiel TA, J Contney S, Bosnjak ZJ, Kampine JP, Roman RJ, Stekiel WJ. Reversal of minimum alveolar concentrations of volatile anesthetics by chromosomal substitution. Anesthesiology. 2004; 101: 796-798.
Rieder MJ, Lombard JH, Roman RJ, Greene AS. Reversal of reduced renal mass hypertension and microvascular rarefaction. Hypertension. 1997; 30:120-127.
Ito O, Roman RJ. Role of 20-HETE in elevating chloride transport in the thick ascending limb of Dahl SS/Jr rats. Hypertension. 1999; 33:419-423.
Zou, A-P, Drummond H, Roman RJ. Role of 20-HETE in elevating loop chloride transport in Dahl SS/Jr rats. Hypertension. 1996; 27 (part 2):631-635, 1996
Qin X, Kwansa, H, Bucci E, Roman RJ, Koehler RC Role of 20-HETE in the pial arteriolar constrictor reponse to decrease hematocrit after exchange transfusion of cell-free polymeric hemoglobin J Appl Physiol. 2006; 100:336-42
Qin X, Kwansa, H, Bucci E, Roman RJ, Koehler RC. Role of 20-HETE in the pial arteriolar constrictor reponse to decrease hematocrit after exchange transfusion of cell-free polymeric hemoglobin. J Appl Physiol. 2006; 100:336-42.
Miyata N, Roman RJ Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system J Smooth Muscle Res. 2005; 41:175-93
Miyata N, Roman RJ. Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. J Smooth Muscle Res. 2005; 41:175-93.
Yousif MHM, Benter IF, Dunn KM, Dahly-Vernon AJ, Akhatar S, Roman RJ Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes J Autonomic and Autacoid Pharmacology. 2009; 29:1-12
Yousif MHM, Benter IF, Dunn KM, Dahly-Vernon AJ, Akhatar S, Roman RJ. Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes. J Autonomic and Autacoid Pharmacology. 2009; 29:1-12.
Alonso-Galicia M, Maier KG, Greene AS, Cowley AW Jr, Roman, RJ. Role of 20-hydroxyeicosatrienoic acid in the renal and vasoconstrictor actions of angiotensin II. Am. J. Physiol. 2002; 283:R60-R68.
Zou A-P, Muirhead EE, Cowley Jr AW, Mattson DL , Falck JR, Jian J, Roman RJ. Role of changes in renal hemodynamics and P450 metabolites of arachidonic acid in the reversal of 1K, 1C- hypertension. J. Hypertension. 1995; 13:557-566.
Harder DR, Campbell WB, Roman RJ. Role of cytochrome P450 enzymes in the control of vascular tone. J. Vasc. Research. 1995; 32:79-92.
Gebremedhin D, Ma Y-H, Imig JD, Harder DR, Roman RJ. Role of cytochrome P450 in the enhanced tone in the juxtamedullary vasculature of SHR. J. Vasc. Res. 1993; 30:53-60.
Sarkis A, Roman RJ Role of cytochrome P450 metabolites of arachidonic acid in hypertension Current Drug Metabolism 2004; 5:245-256
Sarkis A, Roman RJ. Role of cytochrome P450 metabolites of arachidonic acid in hypertension. Current Drug Metabolism 2004; 5:245-256.
Williams JM, Sharma M, Anjaiahh S, Falck JR, Roman RJ Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular permeability barrier Am J Physiol. 2007; 293:501-505
Williams JM, Sharma M, Anjaiahh S, Falck JR, Roman RJ. Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular permeability barrier. Am J Physiol. 2007; 293:501-505.
Lopez B, Moreno C, Salom MG, Roman RJ, and Fenoy FJ. Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide. Am J Physiol. 2001; 281:F420-F427.
Okamoto H, Ito O, Roman RJ, Hudetz AG. Role of inducible isoforms of nitric oxide synthase and cyclooxygenase in endotoxin-induced cerebral hyperemia. Stroke. 1998; 29:1209-1218.
Mattson DL, Roman RJ. Role of kinins and prostaglandins in the renal hemodynamic response to captopril. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol. 29). 1991; F670-F679.
Regner KR, Roman RJ. Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury. Current Opin Nephrol and Hypertension. 2012; 21:33-38.
Chen JX, Zeng H, Lawrence ML, Sadikot RT, Blackwell TS, Meyrick B. Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis. Am J Physiol Heart Circ Physiol, 2006; 291:1563-1572.
Imig JD, Gebremedhin D, Harder DR and Roman RJ. Role of nitric oxide in the renal vasoconstrictor response to erythrocytes. Am. J. Physiol. 1993; 264 (Heart Circ. Physiol. 33):H190-H195.
Mattson DL, Roman RJ, Cowley Jr AW. Role of nitric oxide on renal juxtamedullary blood flow and sodium excretion. Hypertension. 1992; 19:766-769.
Garcia-Estañ J, Roman RJ. Role of renal interstitial pressure in the pressure-natriuresis response. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 25). 1989; F57-F63.
Zhu J, Drenjancevic-Peric I, McEwen S, Friesema J, Schulta D, Yu M, Roman RJ, Lombard JH Role of superoxide and angiotensin II suppression in salt-induced changes in endothelial Ca2+ signaling and NO production in rat aorta Am J Physiol. 2006; 291:H929-38
Zhu J, Drenjancevic-Peric I, McEwen S, Friesema J, Schulta D, Yu M, RomanRJ, Lombard JH. Role of superoxide and angiotensin II suppression in salt-induced changes in endothelial Ca2+ signaling and NO production in rat aorta. Am J Physiol. 2006; 291:H929-38.
Cowley AW Jr, Roman RJ. Role of the kidney in hypertension. JAMA. 1996; 275:1581-1589.
Cowley AW, Mattson DL, Fenoy FJ, Roman RJ. Role of the renal medulla in the long-term control of arterial pressure. J. Hypertension. 1992; 10:S187-S193.
Osborn JL, Ewens J, Roman RJ. Role of the renal nerves in the development of hypertension in the Dahl S rat. Hypertension. 1988; 11: 523-527.
Sun C-W, Falck JR, Harder DR, Roman RJ. Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles. Hypertension. 1999; 33:414-418.
Renic M, Kumar S, Gebremedhin D, Florence MA, Gerges NZ, Falck JR, Harder DR Roman RJ. Protective effect of 20-HETE in a model of oxygen-glucose deprivation in hippocampal slice cultures Am J Physiol 2012 (In press) 000:H000-H000
Zhu J, Yu M, Friesema J, Huang T, Roman RJ, Lombard JH Salt-Induced Angiotensin II Suppression Impairs the Response of Cerebral Artery Smooth Muscle Cells to Prostacyclin Am J Physiol. 2005; 288:H908-H913
Zhu J, Yu M, Friesema J, Huang T, Roman RJ, Lombard JH. Salt-Induced Angiotensin II Suppression Impairs the Response of Cerebral Artery Smooth Muscle Cells to Prostacyclin. Am J Physiol. 2005; 288:H908-H913.
Stiemke MM, Roman RJ, Palmer M, Edelhauser H. Sodium activity of the aqueous humor and corneal stroma of the rabbit. Exp. Eye Res. 1992; 55:428-433.
Roman RJ, Bonventre JV, Silva P, Lenchene CP. Sodium ortho-vanadate diuresis in rats. J. Pharmacol. Exp. Ther. 1981; 218:168-174.
Hudetz AG, Roman RJ, Harder DR. Spontaneous flow oscillations in the cerebral cortex during acute changes in mean arterial pressure. J. Cereb. Blood Flow. 1992; 12:491-499.
Zou A-P, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ. Stereospecific effects of epoxyeicosatrienoic acids on vascular tone and K+-channel activity. Am. J. Physiol. 1996; 270 (Renal Fluid and Electrolyte Physiol. 39): F822-F832.
Mattson DL, Kunert MP, Roman RJ, Jacob HJ and Cowley AW Jr Substitution of chromosome 1 amelorates L-Name hypertension and renal disease in Fawn Hooded Hypertensive Rat Am J Physiol. 2005; 288:F1015-F1022
Mattson DL, Kunert MP, Roman RJ, Jacob HJ and Cowley AW Jr. Substitution of chromosome 1 amelorates L-Name hypertension and renal disease in Fawn Hooded Hypertensive Rat. Am J Physiol. 2005; 288:F1015-F1022.
Williams JM, Burke M, Lazar J, Jacob HJ, Roman RJ Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains Am. J. Physiol 00:000-000, Nov 3, 2010
Williams JM, Burke M, Lazar J, Jacob HJ, Roman RJ. Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains. Am. J. Physiol 00:000-000, Nov 3, 2010.
Dahly AJ, Sharma M, McCarthy ET, Savin VJ, Ledbetter S and Roman RJ TGF-β, 20-HETE interaction and glomerular injury in Dahl S rats Hypertension. 2005; 45:643-648
Dahly AJ, Sharma M, McCarthy ET, Savin VJ, Ledbetter S and Roman RJ. TGF-β, 20-HETE interaction and glomerular injury in Dahl S rats. Hypertension. 2005; 45:643-648.
Kwitek AE, Jacob HJ, Baker JE, Dwindell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA, Roman RJ, Tonellato PH, Cowley AW Jr The BN Phenome: Detailed characterization of the cardiovascular, renal and pulmonary systems of the Sequenced Rat Physiologic Genomics. 2006; 102:799-805
Kwitek AE, Jacob HJ, Baker JE, Dwindell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA, Roman RJ, Tonellato PH, Cowley AW Jr. The BN Phenome: Detailed characterization of the cardiovascular, renal and pulmonary systems of the Sequenced Rat. Physiologic Genomics. 2006; 102:799-805.
Guo AM, Branilava J, Sheng J, Falck JR, Roman RJ, Edwards PA, Arbab AS and Scicli G The CYP4A-20-HETE system in the regulation of endothelial precursor cell derived from human umbilical cord blood J Pharm Exp Therap 2011; 338:421-429
Zagorac D, Yamaura K, Zhang C, Roman RJ, Harder DR The effect of superoxide anion on autoregulation of cerebral blood flow Stroke. 2005; 36:2589-94
Zagorac D, Yamaura K, Zhang C, Roman RJ, Harder DR. The effect of superoxide anion on autoregulation of cerebral blood flow. Stroke. 2005; 36:2589-94.
Rangel-Filho A, Sharma M, Datta Y, Moreno C, Roman RJ, Iwamoto, Y, Provoost A, Lazar J, Jacob HJ The Rf-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the Fawn Hooded Hypertensive rat JASN. 2005; 16:852-856
Rangel-Filho A, Sharma M, Datta Y, Moreno C, Roman RJ, Iwamoto, Y, Provoost A, Lazar J, Jacob HJ. The Rf-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the Fawn Hooded Hypertensive rat. JASN. 2005; 16:852-856.
Zhu D, Effros R, Harder RD, Roman RJ, Jacobs ER. Tissue sources of cytochrome P4504A and 20-HETE synthesis in rabbit lungs. Am J Respir Cell Mol Biol. 1998; 19:121-128.
Harder DR, Narayanan J, Gebremedhin D, Roman RJ. Transduction of Physical Forces by the vascular wall: Role of Phospholipase C and Cytochrome P450 metabolites of Arachidonic Acid. Trends in Cardiovascular Medicine. 1995; 5: 7-14.
Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob H, Roman RJ. Transfer of a salt-resistant renin allele raises arterial pressure in Dahl salt-sensitive rats. Hypertension. 1997; 29:619-628.
Cowley AW Jr, Roman RJ, Kaldunski ML, Dumas P, Greene AS, Jacob HJ. Transfer of Brown Norway rat chromosome 13 into Dahl S genetic background confers protection from a high salt diet. Hypertension. 2001; 37:456-461.
Williams JM, Sarkis A, Hoagland KM, Fredrich K, Ryan RP, Moreno C, Lopez B, Lazar J, Fenoy FJ, Sharma M, Garrett MJ, Jacob HJ, Roman RJ Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury Am J Physiology Renal Physiol. 2008; 295(6): 1764-1777
Williams JM, Sarkis A, Hoagland KM, Fredrich K, Ryan RP, Moreno C, Lopez B, Lazar J, Fenoy FJ, Sharma M, Garrett MJ, Jacob HJ, Roman RJ. Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. Am J Physiology Renal Physiol. 2008; 295(6): 1764-1777.
Hudetz AG, Fenoy F, Roman RJ. Use of fluorescently-labeled erythrocytes and digital cross-correlation for the measurement of flow velocity in the cerebral microcirculation. Microvasc. Res. 1992; 43:343-341.
Roman RJ, Cowley AW Jr., Lechene CP. Water diuretic and natriuretic effect of clonidine in the rat. J. Pharmacol. Exp. Ther. 1979; 211:385-393.
Review Article
Roman RJ. Does 20-HETE mediate the cGMP independent actions of NO? High Blood Pressure Research Newsletter. 1999; 1:20-22.
Roman, RJ. P450 metabolites of arachidonic acid in the control of cardiovascular function. Physiologic Reviews. 2002; 82:131-185.
Sarkis A, Lopez B, Roman RJ Role of 20-HETE and EETS in hypertension Current Opinion in Nephrology and Hypertension. 2004; 13:205-214
Sarkis A, Lopez B, Roman RJ. Role of 20-HETE and EETS in hypertension. Current Opinion in Nephrology and Hypertension. 2004; 13:205-214.
Abstracts
Alonso-Galicia M, Falck JR, Roman RJ 20-HETE agonists and antagonists in the renal circulation Hypertension. 1999; 34:362
Moulana M, Zhang H, Yanes LL, Romero GG, Fan F, Purser CA, Baker R, Roman RJ, Reckelhoff JF 20-HETE and CYP 4A isoforms in a model of postmenopausal hypertension Faseb J. 2011; 25:000
Moulana M, H. Zhang H, Yanes LL, Romero GG, Fan F, Purser CA, Baker R,R.J. Roman, J.F. Reckelhoff. 20-HETE and CYP 4A isoforms in a model of postmenopausal hypertension. Faseb J. 2011; 25:000.
Sun CW, Roman RJ 20-HETE contributes to the inhibition of K channel activity and the vasoconstrictor effect of angiotensin II in rat renal arterioles Hypertension. 1999; 34:338
Alonso-Galicia M, Greene AS, Kurth TM, Cowley AW, Roman RJ 20-HETE contributes to the renal vasoconstrictor actions of angiotensin II FASEB J. 1999; 13:000
Ito O, Roman RJ A deficiency in the formation of 20-HETE elevates chloride transport in isolated perfused thick ascending loop of Henle of Dahl S rats Hypertension. 1998; 32:616
Alonso-Galicia M, Sun CW, Harder DR, Roman RJ A fall in 20-HETE levels contributes to the vasodilator actions of nitric oxide in the cerebral microcirculation Hypertension. 1998; 32:599
Maier KG, Henderson L, Narayanan J, Falck JR, Harder DR, Roman RJ A rapid and sensitive fluorescent HPLC assay for HETEs and EETs FASEB J. 2000;14:A140
Zou AP, Nithipatikon K, Li PL, Roman RJ, Cowley Jr AW Altered renal adenosine metabolism and glomerular hypertension in Dahl S/Jr rats FASEB J 11:000A; 1997.
Maier KG, JC Falcone, IG Joshua, RJ Roman and JC Passmore Altered renal vascular signaling associated with age. FASEB J. 1999; 13:000.
Tuo, QH; Chen, JX; Liao, DF Angiopoietin-1 protects ischemic heart exacerbated by hyperglycemia via increase of angiogenesis JOURNAL OF PHARMACOLOGICAL SCIENCES. 2010; 260P-260P.
Wilson TW, Alonso-Galicia M, Hopp KA, Roman RJ Antihypertensive and renoprotective effects of antilipidemic agents in Dahl S rats Hypertension 29:000, 1997
Zhang J, Williams JM, Roman RJ Assessment of changes in glomerular permeability to albumin in rat models of glomerular disease Faseb. 2011; J 25: 000
Zhang J, Williams JM, Roman RJ. Assessment of changes in glomerular permeability to albumin in rat models of glomerular disease. Faseb. 2011; J 25: 000.
Alonso-Galicia M, Sun CW, Harder DR, Roman RJ Blockade of 20-HETE formation mimics the vasodilator response to nitric oxide in renal arterioles Hypertension. 1998; 32:616
Lombard JH, Fleming JT, Liard JF, Roman RJ Blockade of arachdionic acid metabolism by cytochrome P450 inhibits constriction of rat cremasteric arterioles in response to elevated PO2 FASEB J. 1995; 9:000.
Lu G, Mazet B, Sun C, Qian X, Telford GL, Roman RJ, Sarna SK Characterization of calcium activated potassium currents in human colonic circular smooth muscle cells Am Gastoenterological Association 00:000; 1997
Moreno C, Mattson DL,Guertz A, Dwinell M, Lazar J, Schilling R, Hoffman M, Roman RJ, Cowley AW Jr., Jacob HJ. Characterization of Nap5 KO rat for blood pressure and associated phenotypes. Faseb J 25: 000, 2011.
Zhu D, Khayat R, Raza T, Tomas L Sto, Presberg K, Roman RJ, Harder DR, Baker J, Jacobs ER Chronic hypoxia induces epoxyeicostrienoic acids in neonatal rabbit lungs Am. J. Respiratory:Critical Care Med. 1999; 158:A000
Sun CW, Harder DR, Roman RJ Contribution of cGMP versus 20-HETE in the vasodilator response to NO in rat middle cerebral arterioles FASEB J. 1999; 13:000
Evans RG, Day K, Roman RJ, Hopp KH, Anderson WP Cytochrome P450 arachidonate w-hydroxylase and responses to increased renal perfusion pressure in anaesthetised rabbits J Hypertension 16:000; 1998
Maier KG, Passmore J, Joshua I, Roman RJ Differential effects of 20-HETE and nitroprusside on renal cortical G protein activity FASEB J. 1999; 13:000.
Raza T, Tomas L St, Zhu D, Effros RM, Presberg K, Roman RJ, Jacobs ER Distribution of 20-HETE in lavage fluid of rabbits Am J Respiratory:Critical Care Med. 157:A365; 1998
Maier K, Passmore J, Sun JX, Roman RJ Dysfunction of rho and Gq/11 signal transduction mechansims in rthe reanl cortex in aging FASEB J 11:000; 1997
Pavlov TS, Ilatovskaya D, Roman RJ, Staruschenko A Effects of CYP P450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC) JASN. 2010; 21, 259A
Pavlov TS, Ilatovskaya D, Roman RJ, Staruschenko A. Effects of CYP P450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). JASN. 2010; 21, 259A.
Pavlov TS, Ilatovskaya D, Roman RJ, Staruschenko A Effects of cytochrome P450 metabolites of arachidonic acid on epithelial sodium channel FASEB J. 2010; 24:611.3
Pavlov TS, Ilatovskaya D, Roman RJ, Staruschenko A. Effects of cytochrome P450 metabolites of arachidonic acid on epithelial sodium channel. FASEB J. 2010; 24:611.3.
Pabbidi MR, Juncos J, Burke M, Farley JM, Harder DR, Roman RJ. Enhanced BK (IK(ca)) Channel Activity contributes to lack of myogenic response in the cerebral circulation of Fawn Hooded Hypertensive (FHH) rats Faseb J . 2011; 25: 000
Pabbidi MR, Juncos J, Burke M, Farley JM, Harder DR, Roman RJ. Enhanced BK (IK(ca)) Channel Activity contributes to lack of myogenic response in the cerebral circulation of Fawn Hooded Hypertensive (FHH) rats. Faseb J . 2011; 25: 000.
Zhu D, Roman RJ, Harder DR, Rossi R,Rossi RM, Jacobs ER Epoxyeicosatrienoics acids (EETs) increase the state of activation of rabbit pulmonary arteries FASEB J. 1999; 13:000
Okamoto H, Roman RJ, Kampine JP, Hudetz AG Expression of inducible isoforms of nitric oxide synthase and cyclooxygenase plays an important role in endotoxin-induced cerebral hyperremia in rats J Cerebral Blood Flow and Metab 00:000; 1997
Fan F, Jacob HJ, Guertz A, Murphy S, Roman RJ Generation of CYP4A1 transgenic rats using the Sleeping Beauty transposon system Faseb. 2011; J 25: 000
Fan F, Jacob HJ, Guertz A, Murphy S, Roman RJ. Generation of CYP4A1 transgenic rats using the Sleeping Beauty transposon system. Faseb. 2011; J 25: 000.
Cowley AW Jr, Jacob HJ, Roman RJ, Greene AS, Kaldunski ML, Stoll M, Tonellato PJ Genetic and phenotypic differences of Dahl S/MCW and Brown Norway/MCW inbred rats FASEB J. 1999; 13:000
Roman RJ, Liu R, Williams JM, Burke M, Lazar J, Jacob HJ Genetic basis of alterations in renal hemodynamics and the pathogenesis of glomerular disease in FHH rats Abstracts Renal Hemodynamics Meeting, Saxton River, Vermont, June 2010
Roman RJ, Liu R, Williams JM, Burke M, Lazar J, Jacob HJ. Genetic basis of alterations in renal hemodynamics and the pathogenesis of glomerular disease in FHH rats. Abstracts Renal Hemodynamics Meeting, Saxton River, Vermont, June 2010
Burke M, Pabbidi MR, Williams JM, Liu R, Lazar J, Jacob HJ, Roman RJ Genetic basis of altered myogenic response and renal injury in FHH rats Faseb J. 2011; 25: 000
Burke M, Pabbidi MR, Williams JM, Liu R, Lazar J, Jacob HJ, Roman RJ. Genetic basis of altered myogenic response and renal injury in FHH rats. Faseb J. 2011; 25: 000.
Roman RJ, Williams JM, Burke M, Juncos J, Renic M, Harder D Genetic basis of impaired myogenic response and cerebral blood flow autoregulation FHH rats Faseb. 2011; J 25: 000
Roman RJ, Williams JM, Burke M, Juncos J, Renic M, Harder D. Genetic basis of impaired myogenic response and cerebral blood flow autoregulation FHH rats. Faseb. 2011; J 25: 000
Kaldunski ML, Bork K, Stoll M, Jacob HJ, Roman RJ, Greene AS, Cowley Jr AW Genetic linkage of blood pressure responsiveness in an F2 population derived from Brown Norway and Dahl SS rat intercross FASEB J. 2000; 14:A52
Williams JM, Stelloh C, Regner KR, Roman RJ, Garrett MR Genetic Variants in Arhgef11 linked to Proteinuria, Renal Hemodynamic Parameters, and GFR in the Dahl Salt-Sensitive Rats JASN. 2010; 21: 732A
Williams JM, Stelloh C, Regner KR, Roman RJ, Garrett MR. Genetic Variants in Arhgef11 linked to Proteinuria, Renal Hemodynamic Parameters, and GFR in the Dahl Salt-Sensitive Rats JASN. 2010; 21: 732A.
Jacob HJ, Runte M, Peiffere MM, Granados OS, Roman RJ, Cowley Jr AW Genome cassette system for determining genes and their function in hypertension J Hypertension. 16:000; 1998
Cowley AW Jr, Stoll M, Kaldunski ML, Kurth TM, Greene AS, Roman RJ Genomic scan analysis reveals QTLs on chromosomes 2 and 18 for salt sensitivity of blood pressure in Brown Norway and Dahl S rat F2 intercross Hypertension. 1999; 34:333
Kotchen TA, Piering AW, Bell K, Cowley Jr AW, Grim CE, Gaudet D, Hamet P, Kaldunski ML, Kotchen JM, Roman RJ Glomerular hyperfiltration in hypertensive African Americans Hypertension. 1999 34:334
Nadig V, Kotchen TA, Cowley AW, Grim CE, Hamet P, Jacob H, KotchenJ M, Roman RJ Heritability of blood pressure and blood pressure determineants in hypertensive-dyslipidemic African Americans Am J Hypertension 11: 195A; 1998
Tuo,QH; Yu,H; Chen, JX High glucose blunts angiopoietin-1 (Ang-1)-induced angiogenesis in myocardial endothelial cells via impairment of Akt and eNOS phosphorylation FASEB JOURNAL 2007; 21: A130-A131
Tuo,QH; Yu,H; Chen, JX. High glucose blunts angiopoietin-1 (Ang-1)-induced angiogenesis in myocardial endothelial cells via impairment of Akt and eNOS phosphorylation. FASEB JOURNAL 2007; 21: A130-A131.
Cowley AW Jr, Roman RJ, Green A, Tonellato P, Kotchen T, Hamet P, Gaudet D, Jacob H Hunting for genes of hypertension: A novel paradigm Am J Hypertension. 11,242A; 1998
Chen JX, Meyrick B Hypoxia increases heat shock protein 90 binding (Hsp90) to endothelial nitric oxide synthase (eNOS) via a P13-Akt pathway in porcine coronary artery endothelium (PCAEC) FASEB JOURNAL 2003; 17 : A805-A805
Chen,JX; Meyrick,B. Hypoxia increases heat shock protein 90 binding (Hsp90) to endothelial nitric oxide synthase (eNOS) via a P13-Akt pathway in porcine coronary artery endothelium (PCAEC). FASEB JOURNAL 2003; 17 : A805-A805.
Chen, JX; Zeng, H; Meyrick, B. Hypoxia/reoxygenation-induced myocardial angiogenesis: Role of NADPH oxidase derived reactive oxygen species (ROS) CIRCULATION 114: 2006. 155-155.
Chen JX, Zeng H Meyrick B, Roman RJ Hypoxia/reoxygenation-induced myocardial angiogenesis: Role of NADPH oxidase derived reactive oxygen species (ROS). CIRCULATION 114: 2006. 155-155
Van Dokkum RPE, Sun CW, Provoost AP, Jacob HJ, Roman RJ Impaired autoregulationof RBF and myogenic response in the Fawn Hooded (FHH) rat Hypertension. 1998; 32:602
VanDokkum RPE, Provoost AP, Sun CW, Jacob HJ, Roman RJ Impaired renal vascular responses in the Fawn Hooded hypertensive rat JASN. 1998; 00:000-000
VanDokkum RPE, Jacob HJ, Provoost AP, Roman RJ Increased intraglomerular pressure in Fawn-Hooded hypertensive rats due to impaired autoregulation of renal blood flow J Hypertension 16:189; 1998
Marthaler B, White SM, Van Why SK, Garrett MR, Roman RJ, Regner KR Increased renal CYP4A expression and 20-HETE production promotes resistance to renal ischemia-reperfusion injury in rats JASN. 2010; 21: 788A
Marthaler B, White SM, Van Why SK, Garrett MR, Roman RJ, Regner KR. Increased renal CYP4A expression and 20-HETE production promotes resistance to renal ischemia-reperfusion injury in rats. JASN. 2010; 21: 788A.
Alonso-Galicia M, Frohlich B, Roman RJ Induction of renal P4504A activity with clofibrate normalizes pressure-natriuresis and prevents hypertension in Dahl S rats Hypertension 29 :000; 1997
Ito O, Omata K, Ito S, Roman RJ Induction of the formation of P450 metabolites of arachidonic acid in the kidney by angiotensin converting enzyme inhibitor Hypertension. 1999; 34:360
Lu G, Mazet B, Sun C, Qian X, Johnson CP, Adams MB, Roman RJ Inflammation modulates calcium ativated potassium channel activity in canine colonic circular smooth muscle cells Am Gastroenterological Society 00:000; 1997
Roman RJ Inhibition of 20-HETE formation contributes to the vasodilator effect of NO in the renal and cerebral arterioles Physiologist. 1998; 41:270
Chen JX, Yu H Tuo Q Inhibition of protein tyrosine phosphatase improves hyperglycemic impaired angiogenesis CIRCULATION. 2007; 16: 25-25
Chen, JX; Yu, H; Tuo, Q. Inhibition of protein tyrosine phosphatase improves hyperglycemic impaired angiogenesis CIRCULATION. 2007; 16: 25-25.
Alonso-Galicia, M, Sun CW, Roman RJ Inhibiton of 20-HETE production mediates the cGMP-independent effects of nitric oxide in the renal microcirculation. JASN 8:343A; 1997
SunC, Harder DR, Roman RJ Inhibitory action of 20-HETE on Ca-activated K channel may involve a G-protein dependent mechanism FASEB J 11:A503; 1997
Van Dokkum RPE, Provoost AP, Jacob HJ, Roman RJ Intraglomerular hypertension and hyperfiltration due to impaired renal autoregulation in the Fawn-Hooded rat Am J Hypertension. 11: 1A; 1998
Williams JM, Lazar J, Jacob HJ, Roman RJ Involvement of 20-HETE in Salt-sensitive Hypertension Abstracts Renal Hemodynamics Meeting, Saxton River, Vermont, June 2010
Williams JM, Lazar J, Jacob HJ, Roman RJ. Involvement of 20-HETE in Salt-sensitive Hypertension. Abstracts Renal Hemodynamics Meeting, Saxton River, Vermont, June 2010.
Moreno C, Mattson DL,Guertz A, Dwinell M, Lazar J, Schilling R, Hoffman M, Roman RJ, Cowley AW Jr Jacob HJ. Characterization of Nap5 KO rat for blood pressure and associated phenotypes Faseb J 25: 000, 2011
Chen JX, Yu H, Tuo QH Leptin stimulates angiogenesis in myocardial endothelial cells: Involvement of p47phox NADPH oxidase FASEB JOURNAL 2007; 21: A180-A180
Chen, JX; Yu, H; Tuo, QH Leptin stimulates angiogenesis in myocardial endothelial cells: Involvement of p47phox NADPH oxidase. FASEB JOURNAL 2007; 21: A180-A180.
Hopp KA, Ito O, Roman RJ Localization and quanitation of P4504A mRNA in microdissected nephron segments by RT-PCR FASEB J 11:197; 1997
Ito O, Alonso-Galicia M, Hopp KA, Roman RJ Localization of cyotchrome P4504A isoforms along the rat nephron JASN 8:414A; 1997
Wu F, Ito O, Li PL, Roman RJ, Zou AP, Cowley Jr AW Microassay of 5'-Nucleotidase and adenosine deaminase in microdissected nephron segments of rats FASEB J 11:000; 1997
Sun C, Alonso-Galicia M, Falck JR, Harder DR, Roman RJ NO-20-HETE interaction in the regulation of K channel activity in renal arterioles FASEB J 12:A107; 1998
Roman RJ P450 eicosanoids: Novel signaling pathways regulating renal function and vascular tone Circulation (suppl I). 1998; 98:IB
Roman RJ P450 metabolites of arachidonic acid in the control of vascular tone IOVS. 1998; 39:S9
Omato H, Wang X, Harder DR, Roman RJ Regional differences in cytochrome P4504A1,2,3,8 and 2C11 mRna expression in the rat cerebral microcirculation FASEB J. 2000; 14:A152
Roman RJ , Cowley Jr AW, Mattson D Renal medullary mechanisms in hypertension Am. J. Hypertension. 1995; 8:24A
Cowley AW Jr, Roman RJ, Greene AS, Jacob HJ, Kaldunski ML Renal phenotypic and gender differences between Dahl S/MCW and Brown Norway/MCW rats FASEB J. 1999; 13:000
Beehner K, Falck JR, Roman RJ, Lomwbard JH Role of 20-hete in differential effects of a high salt diet on resistance artery function in Dahl salt-sensitive rats and SS-5BN consomic rats FASEB J. 2010; 24:976.6
Beehner K, Falck JR, Roman RJ, Lomwbard JH. Role of 20-hete in differential effects of a high salt diet on resistance artery function in Dahl salt-sensitive rats and SS-5BN consomic rats. FASEB J. 2010; 24:976.6.
Lombard J.H., R.J. Roman, D.R. Harder, and W.F. Jackson Role of 20-HETE in mediating )2-induced constriction of arterioles in the hamster microcirculation FASEB J 11:000;1997
Chen, JX; Zeng, H; Lawrence, ML. Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis FASEB JOURNAL. 2004;18: A385-A385
Chen, JX; Zeng, H; Lawrence, ML. Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis. FASEB JOURNAL. 2004;18: A385-A385.
Sun CW, Roman RJ Role of PKC and tyrosine kinase in mediating the effects of 20-HETE on K channels and vascular tone in renal arterioles Hypertension. 1998; 32:622
Roman, RJ Role of renal cytochrome P450 pathway in hypertension. Am J Hypertension. 1999; 12: 215A
Raffai G, Wang J, Falck JR, Roman RJ, Lombard JH Salt induced increase in 20-HETE production alters vascular function of mesenteric resistance arteries of Dahl Salt-sensitive rats FASEB J. 2010; 24:979.7
Raffai G, Wang J, Falck JR, Roman RJ, Lombard JH. Salt induced increase in 20-HETE production alters vascular function of mesenteric resistance arteries of Dahl Salt-sensitive rats. FASEB J. 2010; 24:979.7.
Trolliet MR, Krieger JE, Koike G, Simon J, Krieger EM, Stec D, Roman R, Lander ES, Dzau VJ, Jacob HJ Sex specific and sex linked influences on blood pressure in the SHR Hypertension. 1995; 25:1375
Alonso-Galicia M, Falck JR, Harder DR, Roman RJ Structural determinants of the renal vascular response to 20-hydroxyeicosatetraenoic acid (20-HETE) FASEB J 11:A244; 1997
Williams JM, Wells A, Spires D, Roman RJ The progression of diabetes-induced renal injury in Dahl salt-sensitive rats Faseb. 2011; J 25: 000
Williams JM, Wells A, Spires D, Roman RJ. The progression of diabetes-induced renal injury in Dahl salt-sensitive rats. Faseb. 2011; J 25: 000.
Murphy S, Fan F, Jacob HJ, Guertz A, Baker R, Roman RJ Upregulation of the renal production of 20-HETE opposes the development of hypertension in CYP4A1 transgenic Dahl S rats Faseb J. 2011 25: 000
Murphy S, Fan F, Jacob HJ, Guertz A, Baker R, Roman RJ. Upregulation of the renal production of 20-HETE opposes the development of hypertension in CYP4A1 transgenic Dahl S rats. Faseb J. 2011 25: 000.
Book Chapter
Roman RJ Blood flow measurements in the renal circulation. In: Laser-Doppler Flowmetry. Edited by A.P. Shepard and P.A. Oberg. Norwell, MA: Kluwer Academic Press, pp. 289-304, 1990.
Harder DR, Roman RJ, Lombard JH. Cellular and biochemical mechanisms of pressure-induced myogenic tone in arteries. In: Resistance Arteries, Structure and Function. Edited by M.J. Mulvany. Elsevier Science Publishers, 1991, pp. 178-182.
Cowley AW Jr, Roman RJ. Control of blood and extracellular volume. In: Bailliere's Clinical Endocrinology and Metabolism, Vol. 3(2), Chapter 4. London: Harcourt Brace Jovanovich Publishers, 1990, pp. 331-369.
Roman RJ, Harder DJ Cytochrome P450 metabolites of arachidonic acid in the control of renal vascular tone. In: Mechanoreception by the Vascular Wall. Edited by G.M. Rubanyi. Mount Kisco, NY: Futura Pub. Inc., 1993, pp. 155-172
Roman, RJ, Lechene CP. Electron probe microanalysis in health research. In: Yearbook of Science and Technology. New York: McGraw-Hill, pp. 52-61, 1980.
Masters BS, Clark JE, Roman LJ, Roman, RJ, Griffin KJ, Muerhoff AS, Johnson EF. Functional and molecular biological aspects of extrahepatic w-hydroxylation of fatty acids and eicosanoids. In: Proceedings of the VIII International Symposium of Microsomes and Drug Oxidations, Stockholm, 1990.
Chen JX, Zeng H, Chen X, Su CY, Lai CC Heme oxygenase, Ginkgo biloba extract and its terpenoids protect myocytes against oxidative injury. In: Heme Oxygenase in Biology and Medicine NG Abraham, ed., 2002, pp. 399-408
Chen JX, Zeng H, Chen X, Su CY, Lai CC Heme oxygenase, Ginkgo biloba extract and its terpenoids protect myocytes against oxidative injury. In: Heme Oxygenase in Biology and Medicine NG Abraham, ed., 2002, pp. 399-408
Harder DR, Roman RJ, Koehler RC, Alkayed N, Gebremedhin D, Munzenmaier D, Medhora M, Narayanan J. Hyperpolarizing factors and membrane potential in cerebral arterioles: A role for astrocytes and cytochrome P450 genes. In: Hyperpolarizing Factors Edited by P.M..Vanhoute Plenumn Press, NY, 1999, pp 61-67.
Harder DR, Gebremedhin D, Roman RJ. Influence of physical and enviromental factors on ion channels in arterial muscle. In: Ion flux in pulmonary vascular control. ed. by E.K. Weir, Plenum Pub. Co., NY, 1993.
Roman RJ, Mattson DL, Cowley Jr AW. Measurement of regional blood flow in the kidney using laser-Doppler flowmetry. In: Methods in Molecular Medicine, vol 51: Angiotensin Protocols Edited by D. Wang , Humana Press Inc, Totowa, NJ 2000, pp 407-426.
Kauker ML, Zawada ET, Roman RJ. Nisoldipine influence on renal excretory and hemodynamic functions. In: Diuretics III: Chemistry, Pharmacology and Clinical Applications. Edited by J.B. Puschett and A. Greenberg. Amsterdam: Elsevier Scientific Publishing Co., pp. 282-284, 1989.
Harder DR, Sanchez-Ferrer C, Lombard JH, Roman RJ. Pressure-dependent activation in renal arteries and arterioles. In: Proceedings of the 2nd Int. Symposium on Resistance Arteries. Edited by W. Halpern. New York: Perinatology Press, 1988, pp. 369-375.
Harder DR, Kauser K, Lombard JH, Roman RJ, Rubanyi G. Pressure-induced activation of renal and cerebral arteries depends upon an intact endothelium. In: Endothelium-derived Contracting Factors. Edited by G.M. Rubanyi and P. Vanhoutte. Basel: Karger, Volume 2, 1990, pp. 8-13.
Kauser K, Rubanyi GM ,Roman RJ Roman, Harder DR. Pressure-induced endothelium dependent contraction in cat cerebral arteries. In: Neurotransmission and Cerebrovascular Function. Edited by J. Seylaz and E.T. MacKenzie. New York: Excerpta Medica, 1989, pp. 71-76.
Cowley AW Jr, Roman RJ. Renal Mechanisms in Hypertension. In: Handbook of Hypertension, vol 17, Pathophysiology of Hypertension, ed. by A. Zanchetti and G. Mancia, Elsiver Pub. Co., Amsterdam, 1997, pp 740-783
Harder DR, Gebremedhin D, Ma Y-H, Roman RJ. Signal transduction responses to pressure in arterial muscle: A possible role for arachidonic acid metabolites. In: Ion Channels of Vascular and Endothelial Cells. Edited by M. Sperelakis and H. Kuriyama. New York: Elsevier Publishing Co., 1992, pp. 235-238.
Masters BSS, Clark JE, Roman LJ, McCabe TJ, Helm CB, Johnson EF, Ma Y-H, Harder DR, Roman RJ. Structure-function studies and physiological roles of eicosanoids metabolized by cytochrome P-450 w-Hydroxylases. In: Prostaglandin, Leukotrienes, Lipoxins and PAF. ed. by J.M. Bailey, Plenum Press, NY, 1991 pp 59-66.
Cowley, A.W. Jr., and R.J. Roman. The pressure diuresis-natriuresis mechanism in normal and hypertensive states. In: Handbook of HypertensionVol. 8, Pathophysiology of Hypertension-Regulatory Mechanisms. Edited by A. Zanchetti and R.C. Tarazi. Amsterdam: Elsevier Science Publishers B.V., 1986, pp. 295-314.

Presentations

Poster Presentation, Angiopoietin-1 protects ischemic heart exacerbated by hyperglycemia via increase of angiogenesis	2010
National and International Invited Seminars/Lectures, High glucose blunts angiopoietin-1 (Ang-1)-induced angiogenesis in myocardial endothelial cells via impairment of Akt and eNOS phosphorylation., Experimental Biology Meeting, Washington DC	2007
National and International Invited Seminars/Lectures, Leptin stimulates angiogenesis in myocardial endothelial cells: Involvement of p47phox NADPH oxidase., Experimental Biology Meeting, Washington DC	2007
National and International Invited Seminars/Lectures, Hypoxia/reoxygenation-induced myocardial angiogenesis: Role of NADPH oxidase derived reactive oxygen species (ROS), American Heart Association Meeting, Chicago, IL	2006
National and International Invited Seminars/Lectures, Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis, Experimental Biology Meeting, Washington DC	2004
National and International Invited Seminars/Lectures, Hypoxia increases heat shock protein 90 binding (Hsp90) to endothelial nitric oxide synthase (eNOS) via a P13-Akt pathway in porcine coronary artery endothelium (PCAEC)., Experimental Biology Meeting, San Diego, CA	2003

Honors, Awards, and Recognition

UMC excellence in research, Univ of MS Medical Center	2010
NIH Merit Award, National institutes of health heart lung and blood	2005
Program Representative, Water and Electrolyte Section of American Physiological Society	2002
Program Representative, Water and Electrolyte Section of American Physiological Society	2002
Starling Lecture -American Physiological Society	2001
Lewis Dahl Lecture, American Heart Association	1998
Lewis Dahl Lecture-American Heart Association	1998
Program Committee, American Physiological Society	1997
Program Committee APS	1997
Established Investigator American Heart Association	1986
Established Investigator American Heart Association	1986
Starling Lecture, American Physiological Society

Professional Membership and Service

NIH CMBK, Study Section	2010 - 2016
Hypertension, Editor, Associate Editor	2007 - Present
NIH O'Brien Center Grants, Reviewer, Grant Proposal	2007
NIH PKD Center Grants	2005 - 2007
NIH PKD Center Grants, Reviewer, Grant Proposal	2005 - 2007
Physiological Genomics, Editor, Associate Editor	2003 - 2009
Hypertension, Editorial Review Board Member	2002 - 2007
NIH O'Brien Center Grants, Reviewer, Grant Proposal	2002 - 2003
Hypertension, Editor, Associate Editor	2000 - 2003
Hypertension, High blood pressure council meeting edition, Associate Guest Editor	2000 - 2003
NIH NHLBI PPGs, Reviewer, Grant Proposal	1999 - 2010
Am. J. Physiol., Functional Genomics, Editorial Review Board Member	1999 - 2004
Am. J. Physiol., Renal, Fluid and Electrolyte Section, Editorial Review Board Member	1998 - 2008
American Journal Physiology Heart and Cir Physiology, Editor, Associate Editor	1998 - 2003
American Journal Physiology Heart and Circ Physiology, Editor, Associate Editor	1998 - 2003
Am. J. Hypertension, Editorial Review Board Member	1996 - Present
APS Program Committee, Committee Member	1996 - 1999
NIH Cardiovascular-Renal Study Section, Member	1994 - 1999
NIH Cardiovascular-Renal, Reviewer, Grant Proposal, Study Section	1994 - 1999
Am. J. Physiol., Renal, Fluid and Electrolyte Section, Editorial Review Board Member	1992 - 1996
NIH Technology and Innovation Special Study Section, Reviewer, Ad Hoc Reviewer	1992 - 1995
Veterans Administration Merit Review-Nephrology, Reviewer, Grant Proposal	1992 - 1995
Am J. Physiol., Regulatory, Integrative and Comparative Section, Editorial Review Board Member	1991 - 2008
American Heart Association CardioRenal Study Section, Study Section	1991 - 1995
Hypertension, Editorial Review Board Member	1991 - 1995
Am. J. of Med., Reviewer, Journal Article
Am. J. Physiol., Heart and Circulatory; Regulatory and Integrative; Functional Genomics and Fluid and Electrol¬yte Sections., Reviewer, Ad Hoc Reviewer
American Society of Hypertension, American Society of Hypertension
American Society of Hypertension, Member
American Society of Nephrology, Member
American Society of Nephrology, Member
American Society of Physiology, Member
American Society of Physiology, Member
Circ. Res., Reviewer, Journal Article
Council for the Kidney in Cardiovascular Diseases, Fellow
Council on High Blood Pressure Research, Fellow
Electron Microscopy Society of America, Member
Electron Microscopy Society of America, Member
Established Investigator - American Heart Association, Member
Established Investigator - American Heart Association, Member
Europ. J. Pharmacol., Reviewer, Journal Article
Fellow - Council for the Kidney in Cardiovascular Diseases, Member
Fellow Council on High Blood Pressure Research, Member
Hypertension, Reviewer, Ad Hoc Reviewer
International Society of Nephrology, Member
International Society of Nephrology, Member
J Cardiovascular Pharmacology, Reviewer, Journal Article
J. Clin. Invest., Reviewer, Journal Article
J. Lab. Clin. Med., Reviewer, Journal Article
J. of Am. Soc. of Nephrology, Reviewer, Journal Article
J. Pharmacol. Exp. Ther., Reviewer, Journal Article
J. Vascular Res., Reviewer, Journal Article
James Slade Scholar - Rutgers University, Member
James Slade Scholar - Rutgers University, Member
Kidney International, Reviewer, Journal Article
Microcirculatory Society, Member
Microcirculatory Society, Member
NIH Cardiovascular A, Reviewer, Ad Hoc Reviewer
NIH Cardiovascular A, Reviewer, Ad Hoc Reviewer
NIH NHLBI PPGs, Reviewer, Grant Proposal
NIH O’Brien Center Grants, Reviewer
NIH Technology and Innovation, Reviewer, Ad Hoc Reviewer, Special Study Section
Proc. Soc. Exp. Biol., Reviewer, Journal Article
Society for Experimental Biology and Medicine, Member
Society for Experimental Biology and Medicine, Member
Tau Beta Pi, Member
Tau Beta Pi, Member

Committee Service

Graduate Council, Member	2010 - Present
Medical Science Training Program Admission Committee, Member	2010 - Present
Center for Excellence in Cardiovascular Renal Research, Member	2009 - Present
Medical Center - Research Advisory Committee, Member	2009 - Present
Research Strategic Plan Subcommittee: Core Facilities, Chair	2009 - Present
Research Strategic Plan Subcommittee: Research Park/Tech Transfer and Contract based Research, Chair	2009 - Present
School Of Medicine - Executive Faculty, Member	2009 - Present

Teaching Experience

Directed Student Learning

Dissertation Committee Chair, Advised: jin zhang	2009 - Present
Dissertation Committee Chair, Advised: Marylin burke	2009 - Present
Dissertation Committee Chair, The Effects of Phospholipase D Activity and Phosphatidic Acid Synthesis on the Production of Pro-inflammatory Cytokine Production Advised: Michelle Tucci	1995 - 1999
Dissertation Committee Chair, The Effect of Ethanol on the Mobilization of Arachidonic Acid in a Macrophage Cell Line Advised: Chia-Yu Chang	1993 - 2000
Dissertation Committee Chair, Effects of Halothane on Kainate-induced Glutamate Release Uptake in Cultured Cerebellar Granule Cells Advised: Shoumin Zhu	1990 - 1995

Fellows supervised

Pharmacology, Post doctoral research advisor, 3 fellows supervised

Extramural, Regulation of vascular maturation/regression in diabetes, NIH/NHLBI	07/2010 - 05/2014
Extramural, Role of Natriuretic Peptides in the Ductus Arteriosus, NIH/NHLBI	04/2010 - 03/2015
Extramural, (PI) 20-HETE TGFB in hypertension-induced renal injury, NHLBI 7 R37 HL036279-24 (Transfer)	01/2010 - 03/2015
Extramural, Integrative Biology of Childhood Kidney Disease.	10/2009 - 05/2012
Extramural, (Cowley-PI) Blood Pressure – Determinants & Controllers Project 3: Role of Cytochrome P450 eicosanoids in altering pressure natriuresis in hypertension. Role PI project 3., Subaward to P01 HL29587-26 (NIH/NHLBI)	03/2008 - 02/2013
Extramural, Blood Pressure: Determinants & Controllers; Role of CYP Eicosanoids in altering Pressure Natiruesis in Hypertension	03/2008 - 02/2013
Extramural, (Avner-PI) Integrative Biology of Childhood Kidney Disease, Genetic Basis of Altered Renal Hemodynamics and the Development of Glomerular Disease in FHH rats. Role: Co-Investigator on project 2., P50 DK079306-03 (NIDDK)	08/2007 - 06/2012
Extramural, 20-HETE-TGF-beta in Hypertension-Induced Renal Injury., NIH	04/2005 - 03/2015
Extramural, (Harder-PI) Mechanisms Regulating Nutritive Cerebral Blood Flow. Role: Project 2 leader, Biochemical Core Director, Project 2: 20-HETE in hemorrhagic stroke, 1-PO1 HL59996-07 (NIH/NHLBI)	02/2005 - 01/2010

Richard J. Roman, PhD

Education

Current Positions

Academic Appointments or Other Previous Appointments

Sponsored Program Funding

Publications

Journal Article

Review Article

Abstracts

Book Chapter

Presentations

Honors, Awards, and Recognition

Professional Membership and Service

Committee Service

Teaching Experience

Directed Student Learning

Fellows supervised