Samar Rezq, PhD
Assistant Professor
Department:
SOM-Pharmacology/Toxicology
Email:
srezq@umc.edu
Work Phone:
(601) 984-1500
Biography
Dr. Samar Rezq got her B.Sc. in Pharmaceutical Sciences in 2005 and M.Sc. in Pharmaceutical Sciences in 2010 from the Faculty of Pharmacy, Zagazig University, Egypt. She was awarded Ph.D. Scholarship to the USA from the Egyptian Ministry of Higher Education in 2012 to get her Ph.D. in Pharmacology and Toxicology from Brody School of Medicine, East Carolina University, NC, the USA in 2016. She returned to her home country Egypt in 2016 and worked as Lecturer of Pharmacology and Toxicology at the Faculty of Pharmacy, Zagazig University, Egypt. She worked as a Postdoctoral fellow (January 2019-May 2021) then as an instructor at the Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA. She was awarded Endocrinology and Metabolism Section 2020 Research Recognition award and Renal Section 2021 Research Recognition Award from the American Physiological Society, the 2021 Leadership Junior Faculty Award (WIN conference 2021), and the 2022 Early career Faculty Travel Award from the American Society of Biochemistry and Molecular Biology. Her research focuses on the role of MicroRNA-21 in the metabolic derangements in Polycystic Ovary Syndrome and the molecular mechanisms involved in androgen-mediated renal injury in females. She has a total of 30 publications, 13 as the first or co-first author and 9 as the corresponding author.
Education
| Brody School of Medicine, ECU, PhD, Pharmacology and Toxicology | 2016 |
| Zagazig university, MS, Pharmacology and Toxicology | 2010 |
| Zagazig University, BS, Pharmacy | 2005 |
Current Positions
| Assistant Professor, School of Medicine, Department of Biochemistry | 07/2022 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Instructor, University of Mississippi Medical Center, School of Medicine, Department of Biochemistry | 06/2021 - 06/2022 |
| Postdoctoral Research Fellow, University of Mississippi Medical Center, School of Medicine, Department of Biochemistry | 01/2019 - 05/2021 |
Publications
Journal Article | |
| Alsemeh AE, Ahmed MM, Fawzy A, Samy W, Tharwat M, Rezq S, Vitamin E rescues valproic acid-induced testicular injury in rats: Role of autophagy. Life sciences, 2022 May 1;296:120434 | 2022 |
| Mahmoud NM, Elshazly SM, Rezq S, Geraniol protects against cyclosporine A-induced renal injury in rats: Role of Wnt/β-catenin and PPARγ signaling pathways. Life sciences, 2022 Feb 15;291:120259 | 2022 |
| Hamoud MMS, Osman NA, Rezq S, A A Abd El-Wahab H, E A Hassan A, Abdel-Fattah HA, Romero DG, Ghanim AM, Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages. Bioorganic chemistry, 2022 Jul;124:105808 | 2022 |
| Huffman AM, Rezq S, Basnet J, Yanes Cardozo LL, Romero DG, SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19. International journal of molecular sciences, 2021 Apr 25;22(9) | 2021 |
| Ghanim AM, Rezq S, Ibrahim TS, Romero DG, Kothayer H, Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition. European journal of medicinal chemistry, 2021 Jul 5;219:113457 | 2021 |
| Badr S, Rezq S, Abdelghany RH, Endogenous β-endorphin plays a pivotal role in angiotensin II-mediated central neurochemical changes and pressor response. Chemico-biological interactions, 2021 Jun 1;342:109475 | 2021 |
| Yanes Cardozo LL, Rezq S, Pruett JE, Romero DG, Androgens, the kidney, and COVID-19: an opportunity for translational research. American journal of physiology. Renal physiology, 2021 Feb 1;320(2):F243-F248 | 2021 |
| Rezq S, Huffman AM, Basnet J, Yanes Cardozo LL, Romero DG, Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19. International journal of molecular sciences, 2021 Sep 9;22(18) | 2021 |
| Rezq S, Hassan R, Mahmoud MF, Rimonabant ameliorates hepatic ischemia/reperfusion injury in rats: Involvement of autophagy via modulating ERK- and PI3K/AKT-mTOR pathways. International immunopharmacology, 2021 Nov;100:108140 | 2021 |
| Rezq S, Mahmoud MF, El-Shazly AM, El Raey MA, Sobeh M, Anti-Inflammatory, Antipyretic, and Analgesic Properties of Potamogeton perfoliatus Extract: In Vitro and In Vivo Study. Molecules (Basel, Switzerland), 2021 Aug 10;26(16) | 2021 |
| Sakr A, Rezq S, Ibrahim SM, Soliman E, Baraka MM, Romero DG, Kothayer H, Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities. Journal of enzyme inhibition and medicinal chemistry, 2021 Dec;36(1):1810-1828 | 2021 |
| Rezq S, Alsemeh AE, D'Elia L, El-Shazly AM, Monti DM, Sobeh M, Mahmoud MF, Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats. Scientific reports, 2020 Nov 25;10(1):20559 | 2020 |
| Hegazy N, Rezq S, Fahmy A, Mechanisms Involved in Superiority of Angiotensin Receptor Blockade over ACE Inhibition in Attenuating Neuropathic Pain Induced in Rats. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020 Jul;17(3):1031-1047 | 2020 |
| Sobeh M, Rezq S, Cheurfa M, Abdelfattah MAO, Rashied RMH, El-Shazly AM, Yasri A, Wink M, Mahmoud MF, Thymus algeriensis and Thymus fontanesii: Chemical Composition, In Vivo Antiinflammatory, Pain Killing and Antipyretic Activities: A Comprehensive Comparison. Biomolecules, 2020 Apr 13;10(4) | 2020 |
| Hegazy N, Rezq S, Fahmy A, Renin-angiotensin system blockade modulates both the peripheral and central components of neuropathic pain in rats: Role of calcitonin gene-related peptide, substance P and nitric oxide. Basic & clinical pharmacology & toxicology, 2020 Dec;127(6):451-460 | 2020 |
| Elshazly SM, Alsemeh AE, Ahmad EAA, Rezq S, CoQ10 exerts hepatoprotective effect in fructose-induced fatty liver model in rats. Pharmacological reports : PR, 2020 Aug;72(4):922-934 | 2020 |
| Nasr AM, Rezq S, Shaheen A, Elshazly SM, Renal protective effect of nebivolol in rat models of acute renal injury: role of sodium glucose co-transporter 2. Pharmacological reports : PR, 2020 Aug;72(4):956-968 | 2020 |
| Sobeh M, Mahmoud MF, Rezq S, Abdelfattah MAO, Mostafa I, Alsemeh AE, El-Shazly AM, Yasri A, Wink M, Haematoxylon campechianum Extract Ameliorates Neuropathic Pain via Inhibition of NF-κB/TNF-α/NOX/iNOS Signalling Pathway in a Rat Model of Chronic Constriction Injury. Biomolecules, 2020 Mar 2;10(3) | 2020 |
| Rezq S, Nasr AM, Shaheen A, Elshazly SM, Doxazosin down-regulates sodium-glucose cotransporter-2 and exerts a renoprotective effect in rat models of acute renal injury. Basic & clinical pharmacology & toxicology, 2020 May;126(5):413-423 | 2020 |
| Sobeh M, Mahmoud MF, Rezq S, Alsemeh AE, Sabry OM, Mostafa I, Abdelfattah MAO, El-Allem KA, El-Shazly AM, Yasri A, Wink M, Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-κB/TNF-α/NOX/iNOS Pathway. Antioxidants (Basel, Switzerland), 2019 Oct 12;8(10) | 2019 |
| Hegazi NM, Sobeh M, Rezq S, El-Raey MA, Dmirieh M, El-Shazly AM, Mahmoud MF, Wink M, Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo. Scientific reports, 2019 Jul 31;9(1):11122 | 2019 |
| Sobeh M, El-Raey M, Rezq S, Abdelfattah MAO, Petruk G, Osman S, El-Shazly AM, El-Beshbishy HA, Mahmoud MF, Wink M, Chemical profiling of secondary metabolites of Eugenia uniflora and their antioxidant, anti-inflammatory, pain killing and anti-diabetic activities: A comprehensive approach. Journal of ethnopharmacology, 2019 Aug 10;240:111939 | 2019 |
| Sobeh M, Rezq S, Sabry OM, Abdelfattah MAO, El Raey MA, El-Kashak WA, El-Shazly AM, Mahmoud MF, Wink M, Albizia anthelmintica: HPLC-MS/MS profiling and in vivo anti-inflammatory, pain killing and antipyretic activities of its leaf extract. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019 Jul;115:108882 | 2019 |
| Kothayer H, Ibrahim SM, Soltan MK, Rezq S, Mahmoud SS, Synthesis, in vivo and in silico evaluation of novel 2,3-dihydroquinazolin-4(1H)-one derivatives as potential anticonvulsant agents. Drug development research, 2019 May;80(3):343-352 | 2019 |
| Sakr A, Kothayer H, Ibrahim SM, Baraka MM, Rezq S, 1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study. Bioorganic chemistry, 2019 Mar;84:76-86 | 2019 |
| Ghareeb MA, Sobeh M, Rezq S, El-Shazly AM, Mahmoud MF, Wink M, HPLC-ESI-MS/MS Profiling of Polyphenolics of a Leaf Extract from Alpinia zerumbet (Zingiberaceae) and Its Anti-Inflammatory, Anti-Nociceptive, and Antipyretic Activities In Vivo. Molecules (Basel, Switzerland), 2018 Dec 7;23(12) | 2018 |
| Rezq S, Abdel-Rahman AA, Rostral Ventrolateral Medulla EP3 Receptor Mediates the Sympathoexcitatory and Pressor Effects of Prostaglandin E2 in Conscious Rats. The Journal of pharmacology and experimental therapeutics, 2016 Nov;359(2):290-299 | 2016 |
| Rezq S, Abdel-Rahman AA, Central GPR109A Activation Mediates Glutamate-Dependent Pressor Response in Conscious Rats. The Journal of pharmacology and experimental therapeutics, 2016 Feb;356(2):456-65 | 2016 |
| Mahmoud MF, Rezq S, Alsemeh AE, Abdelfattah MAO, El-Shazly AM, Daoud R, El Raey MA, Sobeh M, Potamogeton perfoliatus L. Extract Attenuates Neuroinflammation and Neuropathic Pain in Sciatic Nerve Chronic Constriction Injury-Induced Peripheral Neuropathy in Rats. Frontiers in pharmacology, 2021;12:799444 | |
| Sobeh M, Mahmoud MF, Petruk G, Rezq S, Ashour ML, Youssef FS, El-Shazly AM, Monti DM, Abdel-Naim AB, Wink M, Syzygium aqueum: A Polyphenol- Rich Leaf Extract Exhibits Antioxidant, Hepatoprotective, Pain-Killing and Anti-inflammatory Activities in Animal Models. Frontiers in pharmacology, 2018;9:566 | |
Presentations
| Poster Presentation, MicroRNA-21 Modulates Brown Adipose Tissue Adipogenesis and Thermogenesis in a Mouse Model of Polycystic Ovary Syndrome, New Trends in Sex and Gender Medicine (2021), Virtual | 10/2022 |
| Poster Presentation, Role of the JAK/STAT3 Pathway in Obesity-Induced Renal Injury in Polycystic Ovary Syndrome, Experimental Biology (2022), Philadelphia, PA | 04/2022 |
| Poster Presentation, The neuroprotective effect of a novel 1,4-Dihydroquinazolin-3(2H)-yl benzamide derivative against chronic constriction injury-induced neuropathic pain in rats., Experimental Biology (2022)., Philadelphia, PA | 04/2022 |
| Poster Presentation, Effect of obesity on androgen-induced renal injury in Polycystic Ovary Syndrome: Role of JAK/STAT3 pathway, Basic Research Forum for Emerging Kidney Scientists (2021), Virtual | 11/2021 |
| National and International Invited Seminars/Lectures, Effect of obesity on androgen-induced renal injury in Polycystic Ovary Syndrome: Role of the JAK/STAT3 pathway., Women in Nephrology (WIN) Leadership Conference, Virtual | 09/2021 |
| National and International Invited Seminars/Lectures, Androgens and Diet Regulation of SARS-CoV-2 Viral Entry Proteins: Implications for COVID-19 Cardiorenal Outcomes Severity in Polycystic Ovary Syndrome, EXPERIMENTAL BIOLOGY 2021, Virtual | 04/2021 |
| National and International Invited Seminars/Lectures, MicroRNA-21 Modulates White Adipose Tissue Browning and Altered Thermogenesis in a Mouse Model of Polycystic Ovary Syndrome, Endo2021/Endocrine Society, Virtual | 03/2021 |
| Poster Presentation, MicroRNA-21 Modulates White Adipose Tissue Browning and Altered Thermogenesis in a Mouse Model of Polycystic Ovary Syndrome, AE-PCOS virtual meeting (2020), Virtual | 11/2020 |
| Poster Presentation, The adipose tissue depot-specific role of microRNA-21 in polycystic ovary syndrome-mediated metabolic derangements, Experimental Biology (2020)., San Diego, CA. | 04/2020 |
| Poster Presentation, Activation of the Prostanoid EP3 Receptor Mediates Central Nicotinic Acid-Evoked Pressor Response in Conscious Rats, Experimental Biology (2015), Boston, MA | 04/2015 |
| Poster Presentation, Central Nicotinic Acid Administration Increases Blood Pressure in Conscious Rats., Experimental Biology (2014), San Diego, CA. | 04/2014 |
Honors, Awards, and Recognition
| Outstanding Abstract Award, Endocrine Society | 2022 |
| Early Career Faculty Travel Award, American Society of Biochemistry and Molecular Biology (ASBMB) | 2022 |
| Leadership Junior Faculty Award (WIN conference 2021)., Women in Nephrology | 2021 |
| Renal Section Research Recognition award, American Physiology Society | 2021 |
| Business Advantage Program for Professionals-Else Scholarship, Millsaps College | 2020 |
| Endocrinology and Metabolism Section Research Recognition award, American Physiology Society | 2020 |
| 15th Annual ECU Neuroscience Symposium award, East Carolina University, NC | 2013 |
| Fully Funded PhD Scholarship, Egyptian Ministry of Higher Education | 2012 |
Professional Membership and Service
| American Society for Biochemistry and Molecular Biology (ASBMB), Member | 2021 - Present |
| American Society of Nephrology (ASN), Member | 2021 - Present |
| Endocrine Society, Member | 2020 - Present |
| American Heart Association (AHA), Member | 2020 - Present |
| American Physiology Society (APS), Member | 2019 - Present |
Committee Service
| American Physiology Society (APS)-Endocrinology and Metabolism Section Award subcommittee., Steering Comittee Member | 2021 - Present |
| Postdoctoral Studies Advisory Committee, Member | 2021 - Present |
| APS-E&M-Trainee Advisory Subcommittee, Member | 2020 - Present |
Community Service
| Editorial Duties, Guest Editor, Frontiers in Pharmacology: Cardiovascular and Smooth Muscle Pharmacology, Renal Pharmacology | 02/2022 - Present |
| Editorial Duties, Review Editor, Frontiers in Pharmacology: Ethnopharmacology | 12/2021 - Present |
| Manuscript reviewer, Review manuscripts for the following journals:1. Journal of Inflammation Research (IF: 6.922). 2. Molecular Medicine (IF: 6.354). 3. Frontiers in Pharmacology (IF: 5.810). 4. Biology of Sex Differences (IF: 5.027). 5. International Journal of Nanomedicine (IF: 5.115). 6. Journal of Translational Medicine (IF: 4.098). 7. Journal of Endocrinology (IF: 4.041). 8. American Journal of Physiology-Endocrinology and Metabolism (IF: 3.469). 9. Drug Design, Development and Therapy (IF: 3.216). 10. Journal of Pain Research (IF: 3.133). 11. Metabolic Brain Disease (IF: 2.726). 12. Cell Biochemistry & Function (IF: 2.63). 13. Experimental and Molecular Pathology (IF: 2.280). 14. Journal of Experimental Pharmacology (IF: 2.24). 15. World Journal of Surgical Oncology (IF: 1.966). 16. Future Cardiology (IF: 1.150). | 2019 - Present |
Directed Student Learning
| Master's Thesis Committee Member, Role of Imidazoline and cannabinoid receptors in hepatic reperfusion injury induced in normal and insulin resistant rats: remote effect on brain. Advised: Rana Kadous | 2018 - Present |
| Research Advisor, Role of Imidazoline and cannabinoid receptors in hepatic ischemia reperfusion injury induced in normal and insulin resistant rats Advised: Reham Hassan | 2018 - Present |
| Master's Thesis Committee Member, Neuroprotective effect of vildagliptin and metformin in metabolic syndrome-induced in rats: role of vitamin D Advised: Noha Alaa | 2018 - Present |
| Master's Thesis Committee Member, Investigating the role of endogenous opioids in blood pressure control. Advised: Safy Karam | 2018 - Present |
| Master's Thesis Committee Member, Mechanisms involved in RAAS modulation of neuropathic pain induced in rats. Advised: Nora Hegazy | 2018 - 2021 |
| Master's Thesis Committee Chair, Renal protective effects of doxazosin and nebivolol in experimental models of renal injury in rats. Advised: Ahmed Abdelhameed | 2017 - 2020 |