Ian A. Paul, PhD
Professor Emeritus
Department:
SOM-Psychiatry
Email:
ipaul@umc.edu
Work Phone:
(601) 815-1136
Education
| NIDDK/NIH, Postdoctoral training, Neuropharmacology | 1993 |
| University of North Carolina at Chapel Hill, PhD, Neurobiology | 1989 |
| University of Pittsburgh, BS, Behavioral Neuroscience | 1983 |
Specialty Certification Licensure
| Licensure, Researcher Class 2, 3, 4, 5, Department of Justice | 03/1994 - 03/2020 |
| Licensure, Controlled Substance Registration | 11/2009 - 12/2012 |
Current Positions
| Director, School of Medicine, Department of Psychiatry | 10/2015 - Present |
| Professor, School of Medicine, Department of Psychiatry | 07/2005 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Director of DNBR, University of MS Medical Center, School of Medicine | 03/2014 - 09/2015 |
Sponsored Program Funding
| Intramural, Center for Psychiatric Neuroscience, Animal Behavioral Core, National Center for Research Resources Center Grant | 01/2012 - 12/2017 |
| Extramural, "Monoamines, gender and cortical network development.", National Institute of Health Public Access | 01/2011 - 12/2015 |
| Extramural, R-03/"Renal and cardiovascular function in a rodent model of autism", National Institute of Health Public Access | 01/2011 - 12/2013 |
| Extramural, Translating theory to practice to diversify the biomedical research community, NIH/NIGMS | 09/2010 - 08/2013 |
| Intramural, Center for Psychiatric Neuroscience, Rodent Behavioral Core, National Center for Research Resources Center Grant | 01/2010 - 12/2012 |
| Extramural, "Career decision-making of future minority biomedical faculty"., NIGMS/NIH | 08/2008 - 08/2012 |
| Extramural, "Serotonin, corpus callosum and autism.", National Institute of Mental Health EUREKA award | 07/2008 - 04/2012 |
| Intramural, Center for Psychiatric Neuroscience, National Center for Research Resources Center Grant | 01/2007 - 12/2012 |
| Intramural, Neuroscience Conference Attendance Teams, UMC, Office of Academic Affairs, Faculty Scholarship Exchange Award | 01/2007 - 12/2008 |
| Intramural, "Imported fire ant venom alkaloids: Behavioral response to selective nitric oxide synthase inhibitor", Department of Pediatrics University of Mississippi Medical Center | 01/2004 - 12/2006 |
| Extramural, "NOS inhibitors and antidepressants actions", National Center for Research Resources Center Grant | 01/2002 - 12/2007 |
| Intramural, Center for Psychiatric Neuroscience, Behavioral Core Faculity, National Center for Research Resources Center Grant | 01/2002 - 12/2007 |
| Intramural, Center for Psychiatric Neuroscience: "Agmatine, neuroprotection and deprssion", National Center for Research Resources | 01/2002 - 12/2007 |
| Intramural, Center for Psychiatric Neuroscience: "Galanin in locus coeruleus-ventral tegmental area axons", National Center for Research Resources Center Grant | 01/2002 - 12/2007 |
| Extramural, "Interaction of excitatory amino acid and monoamine neurotransmitters in the action of antidepressants", NARSAD-National Alliance for Research in Schizophrenia and Depression (Independent Investigator) | 01/2001 - 12/2003 |
| Intramural, "Antidepressant effects of novel therapeutic compounds", Biostream Therapeutics (contract) | 01/2000 - 12/2004 |
| Extramural, "Antidepressant effects of novel therapeutic compounds", Phamacia & Upjohn co (contract) | 01/1999 - 12/2004 |
| Extramural, "Cognitive effects of olanzapine in mice", Eli Lilly & Co (FID-US-A028 Contract) | 01/1999 - 12/2003 |
| Extramural, "Retroviral Effects on Behavorial Response to Abused Drugs", National Institute of Drug Abuse | 01/1999 - 12/2002 |
| Extramural, UMC-51239 "Nitric oxide synthase activity in major depressive disorders and suicide", UMC Suicide Research Program, American Suicide Foundation | 01/1999 - 12/2001 |
| Extramural, "Antidepressant effects of novel therapeutic compounds", SK Corporation (contact) | 01/1998 - 12/2000 |
| Extramural, "Antidepressant effects of reboxetine and pramipexol", Upjohn Pharmaceuticals (contract) | 01/1998 - 12/2000 |
| Extramural, "Dopaminergic mechanisms of stimulant self-administration.", National Institute of Drug Abuse | 01/1996 - 12/2001 |
| Extramural, "Neurobiology of Lyme Disease Encephalitis.:, National Institute of Mental Health | 01/1995 - 12/1998 |
| Extramural, "Neurobiology of the NMDA Receptor complex.", Symphony Pharmaceuticals, Inc. (contract) | 01/1995 - 12/1996 |
| Extramural, "Behavioral and Neuronal Effects of Retoviral Infection", National Institute of Mental Health | 01/1994 - 12/1999 |
| Extramural, National Research Council, National Academy of Science, Research Associateship | 01/1989 - 12/1992 |
| Extramural, National Institute of Mental Health, Awarded to UNC Curriculum in Neurobiology- Predoctoral Traineeship | 01/1983 - 12/1984 |
Publications
Journal Article | |
| Khatri N, Simpson KL, Lin RC, Paul IA, Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology, 2014 Mar;231(6):1191-200 | 2014 |
| Adeosun SO, Hou X, Zheng B, Stockmeier C, Ou X, Paul I, Mosley T, Weisgraber K, Wang JM, Cognitive deficits and disruption of neurogenesis in a mouse model of apolipoprotein E4 domain interaction. The Journal of biological chemistry, 2014 Jan 31;289(5):2946-59 | 2014 |
| Miguel-hidalgo,J.J., Paul, I.A., Wanzo,V, and Banerjee,P.K., Memantime prevents cognitive impairment and reduces Bel-2 and caspase 8 immunoreactibity in rats injected with amyloid B1-40. Eur.J. Pharmacol. 692:38-42,2012 | 2012 |
| Grunewald,M., Johnson,S., Lu,D., Want,Z., Lomberk,G., Albert, P.R., Stockmeier,C.S., Meyer,J.H., Urrutia,R., Miczek,KA., Austin,M.C., Wang,J., Paul,I.A. Woolverton,W.L.,Sittman,D.B.and Ou,X-M. Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. J. Biol. Chem.;287(29):24195-206, 2012 | 2012 |
| Wang,J.,Hou,X.,Adeosun,S.,Hill,R.,Henry,S.,Paul,I.A.,Irwin,R.,Ou,X-M,Bigler,C.S.Brinton,R.D. and Gomez-Sanchez, E. A Dominant Negative ERbeta Splice Variant Determines the Effectiveness of Early or Late Estrogen therapy after Ovariectomy in Rats. PLOS ONE 7:e33493, 2012 | 2012 |
| Harris SS, Maciag D, Simpson KL, Lin RC, Paul IA, Dose-dependent effects of neonatal SSRI exposure on adult behavior in the rat. Brain research, 2012 Jan 6;1429:52-60 | 2012 |
| Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert PR, Stockmeier CA, Meyer JH, Urrutia R, Miczek KA, Austin MC, Wang J, Paul IA, Woolverton WL, Seo S, Sittman DB, Ou XM, Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. The Journal of biological chemistry, 2012 Jul 13;287(29):24195-206 | 2012 |
| Miguel-Hidalgo JJ, Paul IA, Wanzo V, Banerjee PK, Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1-40. European journal of pharmacology, 2012 Oct 5;692(1-3):38-45 | 2012 |
| Harris, S.S., Maciag, D., Simpson, K.L., Lin, R.C.S. and Paul, I.A. Dose-dependent effects of neonatal SSRI exposure on adult behavior. Brain Res. 1429:52-60, 2012 (Online 10/20/2011). | 2011 |
| Darling, R.D., Alzghoul, L., Zhang, J., Khatri, N., Paul, I.A., Simpson, K.L. and Lin, R.C.S. Perinatal citalopram exposure selectively increases locus coeruleus circuit function in male rats. J. Neurosci. 31:16709-16715, 2011. | 2011 |
| Simpson K.L., Weaver K.J., de Villiers-Sidani E., Lu J., Cai Z., Pang Y., Green D., Rodriguez-Porcel F., Paul I.A., Merzenich M.M., Lin R.C.S. Perinatal dysregulation of serotonin alters cortical network function: Implications for autism? Proc. Nat. Acad. Sci. 108:18465-18470, 2011 (Online publication 10/24/2011) | 2011 |
| Rodriguez-Porcel, F., Green, D.L., Khatri, N., Harris, S., May, W., Lin, R.C.S. and Paul, I.A. Neonatal exposure of rats to antidepressants affects behavioral reactions to novelty and social interactions in a manner analogous to autistic spectrum disorders. Anat. Record 294:1726-1735, 2011 (Online publication 9/08/2011). | 2011 |
| Ou XM, Johnson C, Lu D, Johnson S, Paul IA, Austin MC, Iyo AH, Miguel-Hidalgo JJ, Luo J, Bell RL, Grunewald M, Wang J, Sittman DB, Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats. Neurotoxicity research, 2011 May;19(4):511-8 | 2011 |
| Zhang J, Darling RD, Paul IA, Simpson KL, Chen K, Shih JC, Lin RC, Altered expression of tyrosine hydroxylase in the locus coeruleus noradrenergic system in citalopram neonatally exposed rats and monoamine oxidase a knock out mice. Anatomical record (Hoboken, N.J. : 2007), 2011 Oct;294(10):1685-97 | 2011 |
| Rodriguez-Porcel F, Green D, Khatri N, Harris SS, May WL, Lin RC, Paul IA, Neonatal exposure of rats to antidepressants affects behavioral reactions to novelty and social interactions in a manner analogous to autistic spectrum disorders. Anatomical record (Hoboken, N.J. : 2007), 2011 Oct;294(10):1726-35 | 2011 |
| Simpson KL, Weaver KJ, de Villers-Sidani E, Lu JY, Cai Z, Pang Y, Rodriguez-Porcel F, Paul IA, Merzenich M, Lin RC, Perinatal antidepressant exposure alters cortical network function in rodents. Proceedings of the National Academy of Sciences of the United States of America, 2011 Nov 8;108(45):18465-70 | 2011 |
| Darling RD, Alzghoul L, Zhang J, Khatri N, Paul IA, Simpson KL, Lin RC, Perinatal citalopram exposure selectively increases locus ceruleus circuit function in male rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011 Nov 16;31(46):16709-15 | 2011 |
| Zhang, J., Darling, R., Paul, I.A., Simpson, K.L., Chen, K., Shih, J.C. and Lin, R.C.S. Altered expression of tyrosine hydroxylase in the locus coeruleus noradrenergic system following perinatal manipulations. Anat. Record 294:1685-1697, 2011 (Online publication 11/13/10) | 2010 |
| Weaver, K.J., Paul, I.A., Lin, R.C.S. and Simpson, K.L. Neonatal Exposure to citalopram selectively alters the expression of the serotonin transporter in the hippocampus: Dose-dependent effects. Anat. Record. 293:1920-1932, 2010 (Online publication 9/9/2010). | 2010 |
| Ou, X, Johnson, C, Lu, D, Johnson, S, Paul, IA, Austin, MC, Iyo, AH, Miguel-Hidalgo, JJ, Luo, J, Bell, RL, Grunewald, M, Wang, J and Sittman, DB Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats. Neurotoxicity Research 19:511-518, 2011. (Online publication 3/5/2010) | 2010 |
| Shen, X., Purser, C., Tien, L-T, Chiu, C-T, Paul, I.A., Baker, R., Loh, H.H., Ho, I.K. and Ma, T. μ-Opioid receptor knockout mice are insensitive to methamphetamine-induced behavioral sensitization. J. Neurosci. Res. 88:2294-2302, 2010. (Online publication 3/5/2010) | 2010 |
| Wallace, K.L., Wyatt-Ashmead, J.A., Paul, I.A. and Bennett, W.A. Interleukin-10/Ceftriaxone prevents E.Coli-induced delays in sensorimotor task learning and spatial memory in neonatal and adult Sprague Dawley rats. Brain Res. Bull. 81:141-148, 2010. | 2010 |
| Wallace KL, Lopez J, Shaffery JP, Wells A, Paul IA, Bennett WA, Interleukin-10/Ceftriaxone prevents E. coli-induced delays in sensorimotor task learning and spatial memory in neonatal and adult Sprague-Dawley rats. Brain research bulletin, 2010 Jan 15;81(1):141-8 | 2010 |
| Shen X, Purser C, Tien LT, Chiu CT, Paul IA, Baker R, Loh HH, Ho IK, Ma T, mu-Opioid receptor knockout mice are insensitive to methamphetamine-induced behavioral sensitization. Journal of neuroscience research, 2010 Aug 1;88(10):2294-302 | 2010 |
| Weaver KJ, Paul IA, Lin RC, Simpson KL, Neonatal exposure to citalopram selectively alters the expression of the serotonin transporter in the hippocampus: dose-dependent effects. Anatomical record (Hoboken, N.J. : 2007), 2010 Nov;293(11):1920-32 | 2010 |
| Siwek, M., Dudek, D., Paul, I.A., Sowa, M., Zieba, A., Pilc, A. and Nowak, G. Zinc supplementation augments efficacy of imipramine in treatment-resistant patients: A double-blind, placebo controlled study. J. Aff. Disorders 118:187-195, 2009. | 2009 |
| Siwek M, Dudek D, Paul IA, Sowa-Kućma M, Zieba A, Popik P, Pilc A, Nowak G, Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study. Journal of affective disorders, 2009 Nov;118(1-3):187-95 | 2009 |
| Sun, T., Paul, I.A.. Ho, I.K. Motor function but not acquisition and retention of active avoidance response are impaired in methyl parathion-tolerant rats. J. Biomed. Sci. 13:515-523, 2006. | 2006 |
| Feng, Y., Paul, I.A., LeBlanc, M.H. Nicotinamide reduces hypoxic ischemic brain injury in the newborn rat. Brain Res. Bull., 69:117-122, 2006 (Online publication 12/15/2005). | 2006 |
| Maciag, D., Coppinger, D. and Paul, I.A. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5 HT1 receptor stimulation during development. Brain Res. 1125, 171-175, 2006 (Online publication 11/14/2006). | 2006 |
| Maciag, D., Williams, L., Coppinger, D. and Paul, I.A. Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment. Eur. J. Pharmacol., 532: 265-270, 2006 (Online publication 2/15/2006). | 2006 |
| Maciag, D., Simpson, K.L., Coppinger, D., Lu, Y., Wang, Y., Lin, R.C.S., Paul, I.A. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 31:47-57, 2006. | 2006 |
| Maciag D, Simpson KL, Coppinger D, Lu Y, Wang Y, Lin RC, Paul IA, Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006 Jan;31(1):47-57 | 2006 |
| Maciag D, Williams L, Coppinger D, Paul IA, Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment. European journal of pharmacology, 2006 Feb 27;532(3):265-9 | 2006 |
| Feng Y, Paul IA, LeBlanc MH, Nicotinamide reduces hypoxic ischemic brain injury in the newborn rat. Brain research bulletin, 2006 Mar 31;69(2):117-22 | 2006 |
| Sun TT, Paul IA, Ho IK, Motor functions but not learning and memory are impaired upon repeated exposure to sub-lethal doses of methyl parathion. Journal of biomedical science, 2006 Jul;13(4):515-23 | 2006 |
| Maciag D, Coppinger D, Paul IA, Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development. Brain research, 2006 Dec 13;1125(1):171-5 | 2006 |
| Aricioglu, F., Paul, I.A. and Regunathan, S. Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice. Neurosci. Lett. 354:153-157, 2004. | 2004 |
| Aricioglu F, Paul IA, Regunathan S, Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice. Neuroscience letters, 2004 Jan 9;354(2):153-7 | 2004 |
| Zhu, H., Paul, I.A., Stec, D.E., Peeler, D.F., and Piletz, J.E. “Non-adrenergic” exploratory behavior induced by moxonidine at mildly hypotensive doses in mice. Brain Res. 964:9-20, 2003. | 2003 |
| Zhu H, Paul IA, Stec DE, Peeler DF, Piletz JE, Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses. Brain research, 2003 Feb 21;964(1):9-20 | 2003 |
| Paul IA, Skolnick P, Glutamate and depression: clinical and preclinical studies. Annals of the New York Academy of Sciences, 2003 Nov;1003:250-72 | 2003 |
| Woolverton, W.L., Ranaldi, R., Wang, Z., Ordway, G., Paul, I.A., Petukhov, P., Kozikowski, A. Reinforcing strength of a novel dopamine transporter ligand: Pharmacokinetic and pharmacodynamic mechanisms. J. Pharmacol. Exp. Ther. 303:211-217, 2002. | 2002 |
| Lee, B., Tumu, P. and Paul, I.A. Effects of LP-BM5 MuLV infection on errors and response time in a two-choice serial reaction time task in C57Bl/6 mice. Brain Res. 948:1-7, 2002. | 2002 |
| Woolverton WL, Ranaldi R, Wang Z, Ordway GA, Paul IA, Petukhov P, Kozikowski A, Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms. The Journal of pharmacology and experimental therapeutics, 2002 Oct;303(1):211-7 | 2002 |
| Lee B, Tumu P, Paul IA, Effects of LP-BM5 murine leukemia virus infection on errors and response time in a two-choice serial reaction time task in C57BL/6 mice. Brain research, 2002 Sep 6;948(1-2):1-7 | 2002 |
| Karolewicz, B., Paul, I.A. and Antkiewicz-Michaluk, L. Effect of NOS inhibitor on forced swim test and neurotransmitters turnover in the mouse brain. Pol. J. Pharmacology 53:587-596, 2001. | 2001 |
| Wilcox, K.M., Paul, I.A., Ordway, G.A. and Woolverton, W.L. Role of the dopamine transporter and the sodium channel in the cocaine like discriminative stimulus effects of local anesthetics in rats. Psychopharmacology 157:260-268, 2001. | 2001 |
| Karolewicz, B. and Paul, I.A. Group housing of mice increases immobility and antidepressant sensitivity in the forced swim and tail suspension tests. Eur. J. Pharmacology 415:197-201, 2001. | 2001 |
| Karolewicz B, Paul IA, Group housing of mice increases immobility and antidepressant sensitivity in the forced swim and tail suspension tests. European journal of pharmacology, 2001 Mar;415(2-3):197-201 | 2001 |
| Wilcox KM, Paul IA, Ordway GA, Woolverton WL, Role of the dopamine transporter and the sodium channel in the cocaine-like discriminative stimulus effects of local anesthetics in rats. Psychopharmacology, 2001 Sep;157(3):260-8 | 2001 |
| Paul IA, Antidepressant activity and calcium signaling cascades. Human psychopharmacology, 2001 Jan;16(1):71-80 | 2001 |
| Wilcox, K.M., Rowlett, J.K., Paul, I.A., Ordway, G.A. and Woolverton, W.L. On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: Practical and theoretical concerns. Psychopharmacology 153:139-147, 2000. | 2000 |
| Nowak, G., Li, Y. and Paul, I.A. Chronic glycine treatment desensitizes the behavioral response to 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at the strychnine-insensitive glycine site of the NMDA receptor complex. J. Neural Trans. 107:123-131, 2000. | 2000 |
| Paul, I.A., English, J.A. and Halaris, A.E. Sucrose and quinine intake by maternally-deprived and control rhesus monkeys. Behav. Brain Res. 112:127-134, 2000. | 2000 |
| Lee, B., English, J.A. and Paul, I.A. Murine LP-BM5 infection impairs short-term memory in the water maze. Brain Res. 856:129-134, 2000. | 2000 |
| Harkin, A., Nowak, G. and Paul, I.A. Noradrenergic lesion antagonizes desipramine induced adaptation of NMDA receptors. Eur J. Pharmacol. 389:187-192, 2000. Corrigendum 397:399, 2000. | 2000 |
| Woolverton, W.L., Rowlett, J.K., Wilcox, K.M., Paul, I.A., Kline, R.H., Newman, A., Katz, J. 3’- and 4’-Chloro-substituted analogs of benztropine: Intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys. Psychopharmacology 147:426-435, 2000. | 2000 |
| Woolverton WL, Rowlett JK, Wilcox KM, Paul IA, Kline RH, Newman AH, Katz JL, 3'- and 4'-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys. Psychopharmacology, 2000 Jan;147(4):426-35 | 2000 |
| Lee B, English JA, Paul IA, LP-BM5 infection impairs spatial working memory in C57BL/6 mice in the Morris water maze. Brain research, 2000 Feb 21;856(1-2):129-34 | 2000 |
| Harkin A, Nowak G, Paul IA, Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors. European journal of pharmacology, 2000 Feb 18;389(2-3):187-92 | 2000 |
| Harkin A, Nowak G, Paul IA, Corrigendum to: "Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors". European journal of pharmacology, 2000 Jun 2;397(2-3):399 | 2000 |
| Paul IA, English JA, Halaris A, Sucrose and quinine intake by maternally-deprived and control rhesus monkeys. Behavioural brain research, 2000 Jul;112(1-2):127-34 | 2000 |
| Wilcox KM, Rowlett JK, Paul IA, Ordway GA, Woolverton WL, On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns. Psychopharmacology, 2000 Dec;153(1):139-47 | 2000 |
| Cai, Z., Xiao, F., Lee, B., Paul, I.A. and Rhodes, P.G. Prenatal hypoxia-ischemia alters expression and activity of nitric oxide synthase in the young rat brain and causes learning deficits. Brain Res. Bull. 49:355-365, 1999. | 1999 |
| Harkin, A.J., English, J.A., Hemphill, K., Craft, B. and Paul, I.A. Nitric oxide synthase inhibitors have antidepressant-like properties in mice: 1. Acute treatments are active in the forced swim test. Eur. J. Pharmacol. 372:207-213, 1999. | 1999 |
| Karolewicz, B., Bruce, K.H. and Paul, I.A. Nitric oxide synthase inhibitors have antidepressant-like properties in mice: 2. Chronic treatment results in downregulation of cortical -adrenoceptors. Eur. J. Pharmacol. 372:215-220, 1999. | 1999 |
| Wilcox, K.M., Paul, I.A., Woolverton, W.L. Comparison between dopamine transporter affinity and self-administration potency of local anesthetics in rhesus monkeys. Eur. J. Pharmacol. 367:175-81, 1999. | 1999 |
| English, J.A., Hemphill, K. and Paul, I.A. Increased discriminative potency of phencyclidine in C57BL/6 mice infected with the LP-BM5 retrovirus. Eur. J. Pharmacol. 367:1-5, 1999. | 1999 |
| Wilcox KM, Paul IA, Woolverton WL, Comparison between dopamine transporter affinity and self-administration potency of local anesthetics in rhesus monkeys. European journal of pharmacology, 1999 Feb 19;367(2-3):175-81 | 1999 |
| English JA, Bruce KH, Paul IA, Increased discriminative stimulus potency of phencyclidine in C57B1/6 mice infected with the LP-BM5 retrovirus. European journal of pharmacology, 1999 Feb 12;367(1):1-5 | 1999 |
| Harkin AJ, Bruce KH, Craft B, Paul IA, Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test. European journal of pharmacology, 1999 May 21;372(3):207-13 | 1999 |
| Karolewicz B, Bruce KH, Lee B, Paul IA, Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 2. Chronic treatment results in downregulation of cortical beta-adrenoceptors. European journal of pharmacology, 1999 May 21;372(3):215-20 | 1999 |
| Cai Z, Xiao F, Lee B, Paul IA, Rhodes PG, Prenatal hypoxia-ischemia alters expression and activity of nitric oxide synthase in the young rat brain and causes learning deficits. Brain research bulletin, 1999 Jul 15;49(5):359-65 | 1999 |
| Weed, M., Woolverton, W. and Paul, I.A. Dopamine D1 and D2 receptor selectivities of phenyl-benzazepines in rhesus monkey and rat brain. Eur. J. Pharmacol. 361:129-142, 1998. | 1998 |
| English, J.A., Hemphill, K. and Paul, I.A. LP-BM5 infection impairs acquisition, but not performance, of active avoidance responding in C57Bl/6 mice. FASEB J. 12:175-179, 1998. | 1998 |
| English JA, Hemphill KM, Paul IA, LP-BM5 infection impairs acquisition, but not performance, of active avoidance responding in C57B1/6 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998 Feb;12(2):175-9 | 1998 |
| Weed MR, Woolverton WL, Paul IA, Dopamine D1 and D2 receptor selectivities of phenyl-benzazepines in rhesus monkey striata. European journal of pharmacology, 1998 Nov 13;361(1):129-42 | 1998 |
| Weed, M., Paul, I.A., Dwoskin, L.P., Moore, S.E. Woolverton, W.L. The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys. J. Pharmacol. Exp. Ther. 283:29-38, 1997. | 1997 |
| Chen, H.-H., Ma, T., Paul, I.A., Hume, A.S. and Ho, I.K. Developmental lead exposure and two-way active avoidance training alters the distribution of protein kinase C activity in the rat hippocampus. Neurochem. Res. 22:1119-1125, 1997. | 1997 |
| Zhu, H., Paul, I.A., McNamara, M., Redmond, A., Nowak, G. and Piletz, J.E. Chronic imipramine treatment upregulates IR2-imidazoline receptive sites in rat brain. Neurochem. Int. Jan:101-107, 1997. | 1997 |
| Zhu H, Paul IA, McNamara M, Redmond A, Nowak G, Piletz JE, Chronic imipramine treatment upregulates IR2-imidazoline receptive sites in rat brain. Neurochemistry international, 1997 Jan;30(1):101-7 | 1997 |
| Chen HH, Ma T, Paul IA, Spencer JL, Ho IK, Developmental lead exposure and two-way active avoidance training alter the distribution of protein kinase C activity in the rat hippocampus. Neurochemical research, 1997 Sep;22(9):1119-25 | 1997 |
| Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL, The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys. The Journal of pharmacology and experimental therapeutics, 1997 Oct;283(1):29-38 | 1997 |
| Von Lubitz, D.K., Lin, R.C., Paul, I.A., Beenhakker, M., Boyd, M., Bischofberger, N. and Jacobson, K.A. Postischemic administration of adenosine amine congener (ADAC): Analysis of recovery in gerbils. Eur. J. Pharmacol. 316:171-179, 1996. | 1996 |
| Von Lubitz, D.K., Beenhakker, M., Lin, R.C., Carter, M.F., Paul, I.A., Bischofberger, N. and Jacobson, K.A. Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist. Eur. J. Pharmacol. 302:43-48, 1996. | 1996 |
| Sei, Y., Whitesell, L., Kustova, Y., Paul, I.A., Morse, H.C., Skolnick, P. and Basile, A.S. Altered brain FYN kinase in a murine acquired immunodeficiency syndrome. FASEB J. 10:239-244, 1996. | 1996 |
| Nowak, G., Li, Y. and Paul, I.A. Adaptation of cortical but not hippocampal glutamate-NMDA receptors after chronic citalopram treatment. Eur J. Pharmacol. - Mol. Pharmacol. Sect. 295:75-85, 1996. | 1996 |
| Skolnick, P., Layer, R.T., Popik, P., Nowak, G., Paul, I.A. and Trullas, R. Adaptation of the N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: Implications for the pharmacotherapy of depression. Pharmacopsychiatry 29:23-26, 1996. | 1996 |
| Sei, Y., Paul, I.A., Saito, K., Layer, R., Hartley, J.W., Morse, H.C., Skolnick, P. and Heyes, M.P. Quinolinic acid levels in a murine retrovirus-induced immunodeficiency syndrome. J. Neurochem. 66:296-302, 1996. | 1996 |
| Sei Y, Paul IA, Saito K, Layar R, Hartley JW, Morse HC 3rd, Skolnick P, Heyes MP, Quinolinic acid levels in a murine retrovirus-induced immunodeficiency syndrome. Journal of neurochemistry, 1996 Jan;66(1):296-302 | 1996 |
| Sei Y, Whitesell L, Kustova Y, Paul IA, Morse HC 3rd, Skolnick P, Basile AS, Altered brain fyn kinase in a murine acquired immunodeficiency syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1996 Feb;10(2):339-44 | 1996 |
| Von Lubitz DK, Beenhakker M, Lin RC, Carter MF, Paul IA, Bischofberger N, Jacobson KA, Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist. European journal of pharmacology, 1996 Apr 29;302(1-3):43-8 | 1996 |
| Skolnick P, Layer RT, Popik P, Nowak G, Paul IA, Trullas R, Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression. Pharmacopsychiatry, 1996 Jan;29(1):23-6 | 1996 |
| Nowak G, Li Y, Paul IA, Adaptation of cortical but not hippocampal NMDA receptors after chronic citalopram treatment. European journal of pharmacology, 1996 Jan 4;295(1):75-85 | 1996 |
| Von Lubitz DK, Lin RC, Paul IA, Beenhakker M, Boyd M, Bischofberger N, Jacobson KA, Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils. European journal of pharmacology, 1996 Dec 5;316(2-3):171-9 | 1996 |
| Boschero, A.C., Szpak-Glasman, M., Carneiro, E.M., Bordin, S., Paul, I.A., Rojas, E., Atwater, I. Oxotremorine-M potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors. Am. J. Physiology 268:E336-E342, 1995. | 1995 |
| Nowak, G., Ordway, G.A. and Paul, I.A. Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Res. 675:157-164, 1995. | 1995 |
| Nowak, G., Redmond, A., McNamara, M. and Paul, I.A. Swim stress increases the potency of glycine at the N-methyl-D-aspartate receptor complex. J. Neurochem. 64:925-927, 1995. | 1995 |
| Nowak G, Ordway GA, Paul IA, Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain research, 1995 Mar 27;675(1-2):157-64 | 1995 |
| Nowak G, Redmond A, McNamara M, Paul IA, Swim stress increases the potency of glycine at the N-methyl-D-aspartate receptor complex. Journal of neurochemistry, 1995 Feb;64(2):925-7 | 1995 |
| Paul, I.A., Nowak, G., Layer, R.T., Popik, P. and Skolnick, P. Adaptation of the N-methyl-D-aspartate receptor complex following chronic treatment with antidepressants. J. Pharmacol. Exp. Ther. 269:95-102, 1994. | 1994 |
| von Lubitz, D.K.J.E., Paul, I.A., Ji, X.D., Carter, M., Jacobson, K.A. Chronic adenosine A1 receptor agonists and antagonists: Effect on receptor density and N-methyl-D-aspartate induced seizures in mice. Eur. J. Pharmacol. 253:95-99, 1994. | 1994 |
| Basile, A.S., de Costa, B. and Paul, I.A. Multiple binding sites for [3H]DTG in guinea pig cerebellum: Evidence for the presence of non-specific binding. Eur. J. Pharmacol. 252:139-146, 1994. | 1994 |
| Von Lubitz DK, Paul IA, Ji XD, Carter M, Jacobson KA, Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice. European journal of pharmacology, 1994 Feb 21;253(1-2):95-9 | 1994 |
| Basile AS, DeCosta B, Paul IA, Multiple [3H]DTG binding sites in guinea pig cerebellum: evidence for the presence of non-specific binding. European journal of pharmacology, 1994 Feb 3;252(2):139-46 | 1994 |
| Paul IA, Nowak G, Layer RT, Popik P, Skolnick P, Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. The Journal of pharmacology and experimental therapeutics, 1994 Apr;269(1):95-102 | 1994 |
| Duncan, G.E., Paul, I.A., Breese, G.R. Neuroanatomical differences in the rate of beta-adrenergic receptor adaptation after repeated treatment with imipramine. Psychopharmacol. Bull. 29:401-407, 1993. | 1993 |
| Paul, I.A., Layer, R.L., Skolnick, P. and Nowak, G. Adaptation of the NMDA receptor complex in rat cortex following chronic treatment with electroconvulsive shock or imipramine. Eur. J. Pharmacol. - Mol. Pharmacol. Sec. 247:305-311, 1993. | 1993 |
| von Lubitz, D.K.J.E., Paul, I.A., Bartus, R.T. and Jacobson, K.A. Effects of chronic administration of an adenosine A1 receptor agonist and antagonist on receptor density and N-methyl-D-aspartate induced seizures in mice. Eur. J. Pharmacol. 249:271-280, 1993. | 1993 |
| von Lubitz, D.K.J.E., Paul, I.A., Carter, M. and Jacobson, K.A. Effects of chronic administration of the A1 receptor agonist N6-cyclopentyladenosine and the antagonist 8-cyclopentyl-1,3-dipropylxanthine on spatial learning and memory in mice. Eur. J. Pharmacol. 249:265-270, 1993. | 1993 |
| Nowak, G., Paul, I.A., Popik, P., Young, A. and Skolnick, P. Ca+2 antagonists effect an antidepressant-like adaptation of the NMDA receptor complex. Eur. J. Pharmacol. - Mol. Pharmacol. Sect. 247:101-102, 1993. | 1993 |
| Lewin, A.H., Skolnick, P., Marvizon, J.C., Paul, I.A., and Bowen, J.P. Requirements for high affinity binding of glycine analogs to the glycine site of the N-methyl-D-aspartate receptor complex. Eur. J. Pharmacol. - Mol. Pharmacol. Sec. 247:1-10, 1993. | 1993 |
| Paul, I.A., Rojas, E., Youdim, M.B.H., De Costa, B., Skolnick, P., Pollard, H. and Kuijpers, G.A.J. Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells. FASEB J., 7:1171-1178, 1993. | 1993 |
| Nowak, G., Trullas, R., Skolnick, P. and Paul, I.A. Adaptive changes in the N-methyl-d-aspartate receptor complex following chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid. J. Pharmacol. Exp. Ther. 265:1380-1386, 1993. | 1993 |
| Paul IA, Layer RT, Skolnick P, Nowak G, Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine. European journal of pharmacology, 1993 Nov 15;247(3):305-11 | 1993 |
| Nowak G, Trullas R, Layer RT, Skolnick P, Paul IA, Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid. The Journal of pharmacology and experimental therapeutics, 1993 Jun;265(3):1380-6 | 1993 |
| Lewin AH, Skolnick P, Marvizon JC, Paul IA, Bowen JP, Requirements for high affinity binding of glycine analogs to the glycine site of the NMDA receptor complex. European journal of pharmacology, 1993 Sep 15;247(1):1-10 | 1993 |
| Nowak G, Paul IA, Popik P, Young A, Skolnick P, Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex. European journal of pharmacology, 1993 Sep 15;247(1):101-2 | 1993 |
| Von Lubitz DK, Paul IA, Carter M, Jacobson KA, Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice. European journal of pharmacology, 1993 Nov 16;249(3):265-70 | 1993 |
| Von Lubitz DK, Paul IA, Bartus RT, Jacobson KA, Effects of chronic administration of adenosine A1 receptor agonist and antagonist on spatial learning and memory. European journal of pharmacology, 1993 Nov 16;249(3):271-80 | 1993 |
| Paul IA, Basile AS, Rojas E, Youdim MB, De Costa B, Skolnick P, Pollard HB, Kuijpers GA, Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1993 Sep;7(12):1171-8 | 1993 |
| Paul, I.A., Trullas, R., Skolnick, P. and Nowak, G. Down-regulation of beta-adrenoceptors by chronic treatment with functional NMDA antagonists. Psychopharmacology 106:285-287. 1992. | 1992 |
| Basile, A.S., Paul, I.A., Mirchevich, A., Kuijpers, G. and de Costa, B. Modulation of [3H](+)-pentazocine binding by divalent cations: Evidence for 1 receptor identity as a cation channel. Mol. Pharmacol. 42: 882-889, 1992. | 1992 |
| Basile, A.S., Paul, I.A. and de Costa, B. Differential effects of cytochrome P-450 induction on ligand binding to receptors. Eur. J. Pharmacol. - Mol. Pharmacol. Sect. 227:95-98, 1992. | 1992 |
| Sei, Y., Arora, P., Skolnick, P. and Paul, I.A. Spatial learning impairment in a murine model of AIDS. FASEB J.. 6:3008-3013, 1992. | 1992 |
| Basile AS, Paul IA, Mirchevich A, Kuijpers G, De Costa B, Modulation of (+)-[3H]pentazocine binding to guinea pig cerebellum by divalent cations. Molecular pharmacology, 1992 Nov;42(5):882-9 | 1992 |
| Basile AS, Paul IA, de Costa B, Differential effects of cytochrome P-450 induction on ligand binding to sigma receptors. European journal of pharmacology, 1992 Sep 1;227(1):95-8 | 1992 |
| Sei Y, Arora PK, Skolnick P, Paul IA, Spatial learning impairment in a murine model of AIDS. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1992 Aug;6(11):3008-13 | 1992 |
| Paul, I.A., Duncan, G.E., Mueller, R.A., Hong, J. S. and Breese, G.R. Neural adaptation in response to chronic imipramine and electroconvulsive shock: Evidence for separate mechanisms. Eur. J. Pharmacol. 205:135-143, 1991. | 1991 |
| Nowak, G., Skolnick, P. and Paul, I.A. Species-specific down-regulation of dopamine1 (D1) receptors by chronic imipramine. Pharmacol. Bioc. Behav. 39:769-771, 1991. | 1991 |
| 7. Duncan, G.E., Paul, I.A., Fassberg, J.B., Powell, K.R., Stumpf, W.E. and Breese, G.R. Autoradiographic analysis of the in vivo distribution of 3H-imipramine and 3H-desipramine in brain: Comparison to in vitro binding patterns. Pharmacol. Bioc. Behav. 38:621-631, 1991. | 1991 |
| Paul IA, Duncan GE, Mueller RA, Hong JS, Breese GR, Neural adaptation in response to chronic imipramine and electroconvulsive shock: evidence for separate mechanisms. European journal of pharmacology, 1991 Nov 26;205(2):135-43 | 1991 |
| Nowak G, Skolnick P, Paul IA, Down-regulation of dopamine1 (D1) receptors by chronic imipramine is species-specific. Pharmacology, biochemistry, and behavior, 1991 Jul;39(3):769-71 | 1991 |
| Duncan GE, Paul IA, Fassberg JB, Powell KR, Stumpf WE, Breese GR, Autoradiographic analysis of the in vivo distribution of 3H-imipramine and 3H-desipramine in brain: comparison to in vitro binding patterns. Pharmacology, biochemistry, and behavior, 1991 Mar;38(3):621-31 | 1991 |
| Paul, I.A., Kuypers, G., Youdim, M. and Skolnick, P. Polyamines allosterically inhibit [3H]3 PPP binding to sigma receptors. Eur. J. Pharmacol. 184:203 204, 1990. | 1990 |
| Paul, I.A., Duncan, G.E., Mueller, R.A., Hong, J. S. and Breese, G.R. Assessment of the effects of time course, stress, rat strain, and uptake blockade on the regionally selective rapid adaptation of beta adrenergic and 5HT2 receptors in imipramine treated rats processed in the forced swim test. J. Pharmacol. Exp. Ther. 252:997 1005, 1990. | 1990 |
| Paul IA, Kuypers G, Youdim M, Skolnick P, Polyamines non-competitively inhibit [3H]3-PPP binding to sigma receptors. European journal of pharmacology, 1990 Aug 2;184(1):203-4 | 1990 |
| Paul IA, Duncan GE, Kuhn C, Mueller RA, Hong JS, Breese GR, Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake. The Journal of pharmacology and experimental therapeutics, 1990 Mar;252(3):997-1005 | 1990 |
| Duncan, G. E., Paul, I. A., Fassberg, J. B., Powell, K., Stumpf, W. E., Breese, G. R. Neuroanatomically selective down regulation of beta adrenergic receptors by chronic imipramine treatment: Relationships to the topography of [3H]imipramine and [3H]desipramine binding sites. J. Pharmacol. Exp. Ther. 248:470 477, 1989. | 1989 |
| Duncan GE, Paul IA, Powell KR, Fassberg JB, Stumpf WE, Breese GR, Neuroanatomically selective down-regulation of beta adrenergic receptors by chronic imipramine treatment: relationships to the topography of [3H]imipramine and [3H] desipramine binding sites. The Journal of pharmacology and experimental therapeutics, 1989 Jan;248(1):470-7 | 1989 |
| Paul, I.A., Duncan, G.E., Powell, K.R., Mueller, R.A., Hong, J. S. and Breese, G.R. Regionally specific neural adaptation of beta adrenergic and 5 HT2 receptors following antidepressant administration in the forced swim test and after chronic antidepressant drug treatment. J. Pharmacol. Exp. Ther. 246:956 962, 1988. | 1988 |
| Paul IA, Duncan GE, Powell KR, Mueller RA, Hong JS, Breese GR, Regionally specific neural adaptation of beta adrenergic and 5-hydroxytryptamine2 receptors after antidepressant administration in the forced swim test and after chronic antidepressant drug treatment. The Journal of pharmacology and experimental therapeutics, 1988 Sep;246(3):956-62 | 1988 |
| Duncan, G.E., Criswell, H.E., McCown, T.J., Paul, I.A., Mueller, R.A. and Breese, G.R. Behavioral and neurochemical responses to haloperidol and SCH 23390 in rats treated neonatally or as adults with 6 hydroxydopamine. J. Pharmacol. Exp. Ther. 243:1027 1034, 1987. | 1987 |
| Duncan GE, Criswell HE, McCown TJ, Paul IA, Mueller RA, Breese GR, Behavioral and neurochemical responses to haloperidol and SCH-23390 in rats treated neonatally or as adults with 6-hydroxydopamine. The Journal of pharmacology and experimental therapeutics, 1987 Dec;243(3):1027-34 | 1987 |
| Duncan, G.E., Paul, I.A., Harden, T.K., Mueller, R.A., Stumpf, W.E. and Breese, G.R. Rapid down regulation of beta adrenergic receptors by combining antidepressant drugs with forced swim: A model of antidepressant induced neural adaptation. J. Pharmacol. Exp. Ther. 234:402 408, 1985. | 1985 |
| Duncan GE, Paul IA, Harden TK, Mueller RA, Stumpf WE, Breese GR, Rapid down regulation of beta adrenergic receptors by combining antidepressant drugs with forced swim: a model of antidepressant-induced neural adaptation. The Journal of pharmacology and experimental therapeutics, 1985 Aug;234(2):402-8 | 1985 |
| Adeosun,S., Hou,X., Jiao,Y., Zheng,B., Henry,S., Hill,R., Pani,A., Kyle,P., Ou,X., Mosley,T., Farley,J.M., Stockmeier,C., Paul,I.A., Bigler,S., Brinton,R.D. Allopregnanolone reinstates tyosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's Disease. PLoS ONE7(11);e50040.doi:10.1371/journal.pone.005004. | |
| Zhang,J., Dennis,K.A., Darling,R.D., Alzghoul,L., Paul,I.A., Simpson,K.L. and Lin,R.C.S. Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female rats. Anat.Rec. (submitted) | |
| Adeosun,S., Hou,X., Jiao,Y., Zheng,B., Henry,S., Hill,R., Pani,A., Kyle,P., Mosley,t., Farley,J.M. Stockmeier,C.S., Paul,I.A., Bigler,S., Brinton,R.d., Smeyne,R. and Wang,J. The impact of a neurogenic agent, allopregnanolone, in a rodent model of Parkinson's disease. Nurobiology of Disease (submitted) | |
| Nowak G, Li Y, Paul IA, Chronic glycine treatment desensitizes the behavioral response to 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at the strychnine-insensitive glycine site of the NMDA receptor complex. Journal of neural transmission (Vienna, Austria : 1996), 2000;107(2):123-31 | |
| Karolewicz B, Paul IA, Antkiewicz-Michaluk L, Effect of NOS inhibitor on forced swim test and neurotransmitters turnover in the mouse brain. Polish journal of pharmacology, 2001 Nov-Dec;53(6):587-96 | |
| Paul IA, Trullas R, Skolnick P, Nowak G, Down-regulation of cortical beta-adrenoceptors by chronic treatment with functional NMDA antagonists. Psychopharmacology, 1992;106(2):285-7 | |
| Wallace K, Veerisetty S, Paul I, May W, Miguel-Hidalgo JJ, Bennett W, Prenatal infection decreases calbindin, decreases Purkinje cell volume and density and produces long-term motor deficits in Sprague-Dawley rats. Developmental neuroscience, 2010;32(4):302-12 | |
| Wang JM, Hou X, Adeosun S, Hill R, Henry S, Paul I, Irwin RW, Ou XM, Bigler S, Stockmeier C, Brinton RD, Gomez-Sanchez E, A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats. PloS one, 2012;7(3):e33493 | |
| Adeosun SO, Hou X, Jiao Y, Zheng B, Henry S, Hill R, He Z, Pani A, Kyle P, Ou X, Mosley T, Farley JM, Stockmeier C, Paul I, Bigler S, Brinton RD, Smeyne R, Wang JM, Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease. PloS one, 2012;7(11):e50040 | |
| Zhang J, Dennis KA, Darling RD, Alzghoul L, Paul IA, Simpson KL, Lin RC, Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats. Frontiers in cellular neuroscience, 2013;7:67 | |
| Duncan GE, Paul IA, Breese GR, Neuroanatomical differences in the rate of beta-adrenergic receptor adaptation after repeated treatment with imipramine. Psychopharmacology bulletin, 1993;29(3):401-7 | |
Book Chapter | |
| Sei, Y., Makino, M., Vitkovic, L., Chattopadhyay, S.K., Hartley, J.W., Morse III, H.C., Saito, K., Heyes, M.P., Skolnick, P. and Paul, I.A. Cognitive impairment in a retrovirus-induced immune deficiency syndrome of mice as a model of AIDS dementia. in “Animal models recapitulate aspects of HIV/CNS disease” ed. L. Vitkovic, E. Stover and S.H. Koslow. AIDS Research and Human Retroviruses 11:753-759, 1995. | 1995 |
Presentations
| Regional Invited Seminars/Lectures, “Trying to Create a Rodent Model for Studying Autistic Symptoms.”, Southeastern Child and Adolescent Consortium Annual Meeting, Jackson, MS | 04/2014 |
| Invited Symposia, "Developmental programming and SSRI antidepressants in rats: Clues to the etiology of autism?", Department of Cellular and Stuctural Biology, University of Texas Health Science Center, San Antonio, TX | 2012 |
| National and International Invited Seminars/Lectures, 2011 American Physiological Society Professional Skills Training Course on Writing for Scientific Journals., Orlando, FL | 2011 |
| State/Local Invited Seminars/Lectures, "Early Life antidepressant exposure: A rat model of autistic behaviors, neuroanatomy and physiology.", Women's Health Research Center, University of Mississippi Medical Center, Jackson, Ms | 2010 |
| Invited Symposia, The role of the NMDA receptor signaling cascade in antidepressant activity, American Society of Pharmacology and Experimental Therapeutics, San Diego, CA | 04/2008 |
| Invited Symposia, "Ethics in scientific research", Alliance for Graduate Education in Mississippi (AGEM) Winter Symposium, Oxford, MS | 2007 |
| Invited Symposia, "The role of the nitric oxide-cGMP pathway in mood and stress-related disorders: Implications for understanding their biology and treatment.", collegium Internationale Neuro-Psychopharmacologium XXV Congress, Chicago, IL | 2006 |
| State/Local Invited Seminars/Lectures, "Neurobehavioral responses to fire ant venom alkaloids in rodents., Colloquium on Imported Fire Ant research in Mississippi, Jackson, MS | 2005 |
| Grand Rounds, "Neurobehavioral teratogenicity or antidepressants", Department of Psychiatry, Grand Rounds, Jackson, MS | 2004 |
| State/Local Invited Seminars/Lectures, "Neurobiological teratogenicity of antidepressants", Seminar, UMC Department of Psychiatry Research Day, Jackson, MS | 2004 |
| Invited Symposia, "Excitatory amino acid signaling, major depressive disorders and antidepressant actions"., Symposium, Glutamate and Disorders of Cognition and Motivation (NY Academy of Science Conference), New Haven, CT | 2003 |
| State/Local Invited Seminars/Lectures, "Rubbing a raw nerve: Excitatory signaling and depression., UMC Research Seminar, Jackson, MS | 2002 |
| National and International Invited Seminars/Lectures, "Role of calcium signaling in the action of antidepressants"., Seminar, Merck Research Laboratories, Terlings Park, Essex,U.K. | 2001 |
| Regional Invited Seminars/Lectures, "Antidepressant drug development and excitatory amino acid signaling"., Seminar, Pfizer Laboratories, CNS Discovery, Groton, CT | 2001 |
| Invited Symposia, "Antidepressant activity and calcium signaling cascades"., Antidepressant Workshop-Sponsored by Human Psychopharmacology, Galway, Ireland | 1999 |
| Invited Symposia, "Post-mortem studies of the role of excitatory amino acid neurotransmitters in major depression.", Society for Biological Psychiatry Annual Meeting, Washington, DC | 1999 |
| Grand Rounds, "Excitatory amino acids, calcium and nitric oxide: Novel avenues for antidepressant treatments.", Department of Psychiatry and Human Behavior, University of Mississippi School of Medicine, Jackson, MS | 1999 |
| National and International Invited Seminars/Lectures, "Post mortem studies of the NMDA receptor in human suicide victims"., Third International Meeting of the Polish Society for Neuroscience, Lodz, Poland | 1997 |
| National and International Invited Seminars/Lectures, "The clinical relevance of the NMDA receptor in affective disorders"., Sixth International Congress on Biological Psychiatry, Nice, France | 1997 |
| Invited Symposia, "Use of MAIDS to investigate retroviral effects on learning, memory and drug discriminiation.", AIDSA and Drug Abuse-NIDA/NIH Symposium, Rockville, MD | 1997 |
| Grand Rounds, "Retroviral effects on learning, memory and drug discrimination.", Department of Psychiatry and Human Behavior, Univeristy of Mississippi School of Medicine, Jackson, MS | 1997 |
| National and International Invited Seminars/Lectures, "Major depressive disorder and the NMDA receptor - Evidence from animal models and human suicide victims"., Second International Symposium on Affective Disorders, Jerusalem, Israel | 1995 |
| Invited Symposia, "Learning and memory deficits in a murine model of AIDS and the effects of zidovudine (AZT) treatment., Burroughs-Wellcome Co., Research Triangle Park, NC | 1994 |
| Invited Symposia, "New opportunities in NeuroAIDS research: Animals models- MAIDS.", Society for Neuroscience Satellite Symposiums, Miami, FL | 1994 |
| Grands Rounds, "How antidepressants work: Neural adaptation and the N-methyl-D-aspartate receptor.", Department of Psychiatry and Human Behavior, University of Mississippi School of Medicine | 1993 |
| Invited Symposia, "Recent developments in the study of learning deficits in a murine model of AIDS.", NIAID, NIH, AIDS Therapeutics Branch, Rockville, MD | 1993 |
| Invited Symposia, "Antidepressant interactions with sigma receptors", British Association for Psychopharmacology, Annual Meeting, Cambridge, U.K. | 1993 |
| Invited Symposia, "Partial Agonists at the Glycine Recognition Site of the NMDA Receptor: Neural Adaptation and Therapeutics"., American college Neuropsychopharmacology, Annual Meeting, Honolulu, HI | 1993 |
| Invited Symposia, "Spatial learning deficits in a murine model of AIDS.", Rockefeller University, New York, NY | 1992 |
| Invited Symposia, "Competitive and non-competitive inhibition of (3H)DTG binding to o1 and o2 receptors by antidepressant drugs: A common locus for antidepressant drug activity?", European Society for Neurochemistry, Satellite Symposium, Galway,Ireland | 1992 |
| Invited Symposia, "The use of the WATERMAZ data acquistion program to assess spatial learning deficits accompanying CNS infection with a murine immunosuppressive retrovirus.", I.T.E.M. Labo, Paris, France | 1991 |
| Invited Symposia, "Sigma receptor modulation of nicotinic receptors in adrenal chromaffin cells.", Third Frenc-U.S. Joint Program: Multiple Sigma and PCP Receptor Ligands, Montpellier,France | 1991 |
| Invited Symposia, "Antidepressant effects of NMDA antagonists.", Consejo Superior de Investigaciones Cientificas, Centro de Investigacion y Desarrollo., Barcelona,Spain | 1991 |
Honors, Awards, and Recognition
| M2 All-Star Professor, Carl G. Evers Society | 2021 |
| M2 All-Star Professor, Carl G. Evers Society | 2020 |
| Trailblazer Teaching Award, School of Medicine, University of Mississippi Medical Center | 2018 |
| The Nelson Order, University of Mississippi Medical Center | 2014 |
| Regions Bank T.E.A.C.H. Prize, The University of Mississippi Medical Center | 2014 |
| Travel & Training Fellowship, National Science Foundation Model Curriculum for Land Grant Universities in Research Ethics (LANGURE) project | 2010 |
| Leadership Development Program, University of Mississippi Medical Center | 2008 |
| Excellence in Research award (Gold), University of Mississippi Medical Center | |
| Excellence in Research Award (Bronze), University of Mississippi Medical Center | |
| Co-recipient, Anna-Monika Stiftung (3rd Prize), AGNP | |
| Travel Award Honorable Mention, American college of Neuropschopharmacolgy/Mead Johnson | |
| Chancellor's Undergraduate Teaching Fellowship, University of Pittsburgh | |
| Honorable Mention, National Science Foundation Predoctoral Fellowship |
Professional Membership and Service
| Assoc. Dir. Med. Student Educ. Psychiatry, Member | 2015 - Present |
| American Psychological Association, Member | 2007 - Present |
| Society of Biological Psychiatry, Member | 1994 - Present |
| American Society of Pharmacology and Experimental Therapeutics, Member | 1993 - Present |
| Society for Neuroscience, Member | 1984 - Present |
Committee Service
| SCHOOL OF MEDICINE-CURRICULUM, Member | 2015 - Present |
| SCHOOL OF MEDICINE-MEDICAL STUDENT PROMOTIONS, Member | 2012 - 2012 |
| MEDICAL CENTER-INSTITUTIONAL REVIEW BOARD 1, Member | 2012 - 2015 |
| MEDICAL CENTER-INSTITUTIONAL ASSESSMENT, Member | 2009 - 2012 |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-CURRICULUM, Member | 2008 - 2014 |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-GRADUATE COUNCIL, Member | 2007 - 2014 |
| M.D/Ph.D Program Committee, Member | 2006 - 2009 |
| MEDICAL CENTER-ANIMAL CARE AND USE, Member | 2005 - 2008 |
| Neuroscience Scholars Summer Program, Chair | 2003 - 2012 |
| International Training and Mentoring Committee, Chair | 2002 - 2010 |
| Grand Rounds committee, Member | 2001 - 2002 |
| Promotions and Tenure Committee, Member | 2000 - 2003 |
| Common equipment Manager - DNBR, Chair | 1999 - 2006 |
| Computer Committee, Member | 1999 - 2004 |
| Academic Network Systems Committee, Member | 1996 - 1998 |
| MEDICAL CENTER-ANIMAL CARE AND USE, Member | 1994 - 1997 |
| Executive committee, Member | 1994 - 1995 |
| Graduate Faculty, Member | 1993 - Present |
| Computer Usage Committee, Chair | 1993 - 1998 |
| Curriculum Committee, Member | 1993 - 1994 |
Teaching Experience
| CONJ 638, Medicine, Course, Course Director, Medical Neuroscience & Behavior 3 (Clerkship) | Annual 2020 - 2021 |
| CONJ 628, Medicine, Course, Course Director, Medical Neuroscience & Behavior 2 | Spring 2018 |
| PSYCH 611, Medicine, Course, Course Director, Behavioral Science | Spring 2015 - 2017 |
| PSYCH 621, Medicine, Course, Course Director, Introduction to Psychiatric Diagnosis and Treatment | Spring 2015 - 2017 |
| PSYCH 611, Medicine, Course, Course Director, Junior Clerkship in Psychiatry | Annual 2015 - 2020 |
| Graduate, Course, Course Presenter, Behavioral Neuroscience | Annual 2012 - 2014 |
| Graduate, Course, Course Director, Behavioral Neuroscience | Annual 2012 - 2014 |
| Course, Course Presenter, CNS Parmacology-PIN | 2012 |
| Course, Course Presenter, Developmental Neuroscience-PIN | 2012 |
| Course, Course Presenter, Fundamental Neuroscience | 2012 |
| Course, Course Presenter, Fundamental Neuroscience-PIN | 2012 |
| Lecture, Lecturer, Medical Pharmacology-Department of Pharmacology | 2012 |
| Course, Course Presenter, Millsaps College NCS major senior interships | 2012 |
| Lecture, Lecturer, Research Ethics-SGSHS | 2012 |
| Course, Course Presenter, Special Topics in Neuroscience | 2012 |
| Course, Course Presenter, Special Topics in Neuroscience | 2012 |
| Lecture, Lecturer, Medical Pharmacology | 2010 |
| 735, Lecture, Lecturer, Pharmacology | 2010 |
| Lecture, Lecturer, Pharmacology 621 | 2010 |
| Lecture, Lecturer, Seizure Disorders and Anticonvulsants | 2010 |
| Graduate, Course, Course Director, Research Ethics | Fall 2008 - 2014 |
| Course, Course Director, Systems and Integrative Neuroscience | 2008 |
| Lecture, Lecturer, Cellular and Molecular Neuroscience | 2007 |
| Course, Course Director, CNS Pharmacology | 2007 |
| Course, Course Director, Neuroscience Journal Club | 2007 |
| Lecture, Lecturer, Behavioral Pharmacology & Neuroimmunology | 2005 |
| Lecture, Lecturer, Psychiatry 621, 622 | 1995 |
| Lab, Lab Presenter, Psychopathology | 1995 |
| Course, Instructor, Radioligand Binding Techniques | 1993 |
| Course, Codirector and Instructor, Psychobiology | 1988 |
| Course, Teaching Assistant, Psychobiology | 1983 |
Directed Student Learning
| Dissertation Committee Member, Advised: Kathryn Veazey | 2020 - Present |
| Dissertation Committee Member, Advised: Barak Gunter | 2012 - 2013 |
| Dissertation Committee Member, Advised: Justin Cobb | 2012 - 2013 |
| Dissertation Committee Member, Advised: Loai Alzghoul | 2012 - 2013 |
| Dissertation Committee Member, Advised: Martin Bohlen | 2012 - 2013 |
| Master's Thesis Committee Chair, Non-thesis Masters Advised: Paul Cross | 2011 - 2012 |
| Undergraduate Honors Thesis, Effects of Perinatal Exposure of Rats to SSRIs Advised: Amanda Fertita | 2011 - 2012 |
| Undergraduate Honors Thesis, Neonatal effects of 5HT1A and 5HT1B receptor activation Advised: Leia Golden | 2011 - 2012 |
| Internship Advisor, Advised: Amanda Fertita | 2011 - 2012 |
| Supervised Research, Advised: Paul Cross | 2011 - 2012 |
| Undergraduate Honors Thesis, Dose-dependent effects of neonatal SSRI exposure Advised: Neeharika (Neha) Bhatnagar | 2010 - 2011 |
| Master's Thesis Committee Chair, Advised: Tamara Glenn | 2010 - 2013 |
| Supervised Research, Advised: Samuel Adeosun | 2009 - 2011 |
| Dissertation Committee Chair, Role of early life stimulation of serotonin 1A and 1B (5-HT1A and 5-HT1B) receptors in the lasting neurobehavioral effects of neonatal SSRI exposure Advised: Nidhi Khatri | 2008 - 2012 |
| Supervised Research, Advised: Donald Green | 2008 - 2009 |
| Dissertation Committee Member, The effects of neonatal SSRI exposure on the developing serotonin system as evidenced by quantitative fluorescent immunohistochemical studies in adult rats Advised: Kristin Weaver | 2006 - 2008 |
| Dissertation Committee Member, Advised: Jorge Lopez | 2006 - 2007 |
| Dissertation Committee Chair, Effect of early life exposure to SSRIs on neurobehavioral development and serotonin turnover Advised: Sharonda Swilley | 2005 - 2011 |
| Dissertation Committee Member, Advised: Prashant Mandela | 2004 - 2006 |
| Master's Thesis Committee Member, Advised: Kedra Wallace | 2004 - 2006 |
| Dissertation Committee Member, Advised: Sunmee Wee | 2004 - 2005 |
| Master's Thesis Committee Member, Advised: David Coppinger | 2003 - 2006 |
| Dissertation Committee Member, Advised: Tingting Sun | 2003 - 2004 |
| Supervised Research, Antidepressant-like effects of Nitric Oxide Synthase Inhibitors Advised: Andrew J Harkin | 1996 - 1996 |
| Dissertation Committee Member, Advised: Kristen Wilcox | 1996 - 1999 |
| Dissertation Committee Member, Advised: Hwei-Hsien Chen | 1995 - 1997 |
| Dissertation Committee Chair, Advised: Buyean Lee | 1994 - 1999 |
| Dissertation Committee Member, Advised: Lingen Lu | 1994 - 1997 |
| Dissertation Committee Member, Advised: Michael Weed | 1993 - 1995 |
| Supervised Research, Advised: Sinead Walsh | |
| Supervised Research, Advised: Sandra O'Brien | |
| Supervised Research, Advised: Noreen Boyle | |
| Supervised Research, Advised: Eamon McCay | |
| Supervised Research, Advised: Paul Lavan | |
| Supervised Research, Advised: Kathleen Morris | |
| Supervised Research, Advised: Ruth O'Connor | |
| Supervised Research, Advised: Mark Burns | |
| Supervised Research, Advised: Rachel Nally | |
| Supervised Research, Advised: Andrew Harkin | |
| Internship Advisor, Advised: S. Nick Shaw | |
| Supervised Research, Advised: Anna Redmond | |
| Supervised Research, Advised: Mairead McNamara |
Fellows supervised
| Post-Doc Advisor, 1 fellows supervised | 07/2003 - 06/2006 |
| Post-Doc Advisor, 1 fellows supervised | 07/1997 - 06/1999 |
| Post-Doc Advisor, 1 fellows supervised | 07/1995 - 06/1998 |
| Post-Doc Advisor, 1 fellows supervised | 09/1993 - 08/1995 |