Roy D. Manning
PROFESSOR EMERITUS
Education
| University of Mississippi Medical Center, PhD, Biomedical Engineering/Physiology | 1973 |
| University of Mississippi, MS, Engineering Science | 1971 |
| University of Mississippi, BS, Chemical Engineering | 1968 |
Current Positions
| Professor, School of Medicine, Department of Physiology And Biophysics | 07/1983 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Physiology And Biophysics | 1980 - 1983 |
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Physiology And Biophysics | 1973 - 1980 |
| Research Associate, University of Mississippi Medical Center, School of Medicine, Department of Physiology And Biophysics | 1972 - 1973 |
Sponsored Program Funding
| Extramural, (PI-MANNING) Project 3, “Mechanisms of Salt-Sensitive Hypertension”, (Overall PI-Hall) Cardiovascular Dynamics and their Control, NHLBI | 12/2003 - 11/2008 |
Publications
Journal Article | |
| Zhang Q, Lin L, Lu Y, Liu H, Duan Y, Zhu X, Zou C, Manning RD Jr, Liu R Interaction between nitric oxide and superoxide in the macula densa in aldosterone-induced alterations of tubuloglomerular feedbac Am J Physiol Renal Physiol. 2013 304:F326-F332 | 2013 |
| Tian N, Penman AD, Mawson AR, Manning RD Jr, Flessner MF Association between Circulating Specific Leukocyte Types and Incident Chronic Kidney Disease: the Atherosclerosis Risk in Communities (ARIC) Study J Am Soc Hypertens. 2012:6;100-108 | 2012 |
| Fu Y, John E. Hall JE, Lu D, Lin L, Manning RD Jr , Cheng L, Gomez-Sanchez CE, Juncos LA,Liu R Aldosterone Blunts Tubuloglomerular Feedback by Activating Macula Densa Mineralocorticoid Receptors Hypertension 2012:59;599-606 | 2012 |
| Zhu X, R. Davis Manning, Jr., Deyin Lu, Celso E. Gomez-Sanchez, Yiling Fu, Luis A. Juncos Aldosterone stimulates superoxide production in the macula densa cells American J Physiology: Renal Physiology. 2011:301;F529-35 | 2011 |
| Lai EY, Wang Y, Persson EG, Manning RD Jr, Liu R Pressure induces intracellular calcium changes in juxtaglomerular cells in perfused afferent arterioles Hypertension Res. 2011:3;942-8 | 2011 |
| Tian N, Penman AD, Mawson AR, Manning RD Jr, Flessner MF. Association between circulating specific leukocyte types and blood pressure: the atherosclerosis risk in communities (ARIC) Journal of the American Society of Hypertension 2010 Nov-Dec;4(6):272-83 | 2010 |
| Lu D, Fu Y, Lopez-Ruiz A, Zhang R, Juncos R, Liu H, Manning RD Jr, Juncos L, Liu R. Salt sensitive splice variant of nNOS expressed in the macula densa cells. Am J Physiol Renal Physiol 2010 Jun;298(6):F1465-71. PMCID: PMC2886819 | 2010 |
| Lin L, Phillips WE, Manning RD Jr. Intrarenal angiotensin II is associated with inflammation, renal damage and dysfunction in Dahl salt-sensitive hypertension. Journal of the American Society of Hypertension 2009:3; 306-314. NIHMSID: NIHMS139911. PMID: 20160914 . | 2009 |
| Gu J-W, Manning R D Jr, Young E, Shparago M, Sartin B, Bailey AP. Vascular Endothelial growth Factor Receptor Inhibitor Enhances Dietary Salt-induced Hypertension in Sprague-Dawley (SD) Rats. American Journal Physiology: Regulatory and Integrative Physiology 2009;297:R142-R148. | 2009 |
| Tian N, Moore RS, Phillips WE, Lin L, Braddy S, Pryor JS, Stockstill RL, Hughson MD, and Manning R D Jr NADPH Oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension American Journal Physiology: Regulatory and Integrative Physiology 2008;295 R1858-R1865 | 2008 |
| Hughson M D, Gobe G C, Hoy W E, R. D. Manning R D Jr, Douglas-Denton R, and Bertram J F Associations of Glomerular Number and Birth Weight with Clinical-Pathological Features in Southeastern African Americans and Whites American Journal of Kidney Diseases 2008;52:18-28 | 2008 |
| Tian N, Moore R S, Braddy S, Rose RA, Gu J-W, Hughson M D, Manning R D Jr. Interactions between Oxidative Stress and Inflammation in Salt-Sensitive Hypertension Am J Physiol Heart Circ Physiol 2007;293: H3388-H3395 | 2007 |
| Tian N, Gu J-W, Jordan S, Rose RA, Hughson M D, Manning R D Jr Immune Suppression Prevents Renal Damage and Dysfunction and Reduces Arterial Pressure in Salt-Sensitive Hypertension Am J Physiol Heart Circ Physiol 2007; 292: H1018-H1025 | 2007 |
Abstracts | |
| Lu Y, Ge Y, Manning RD, Jr, Juncos LA, Liu R Expression and function of adenosine A3 receptor in the afferent arteriole Hypertension.2011:58; e139 | 2011 |
| Zhu X, Manning RD Jr, Lu D, Gomez-Sanchez CE, Juncos LA, Liu R Aldosterone increases superoxide production in macula densa cells Hypertension.2010;56: e67 | 2010 |
| Gu J-W, Manning RD Jr, Young E, Tucker KB, Shparago M. Chronic administration of human VEGF 165 protein reduces blood pressure and renal injury in Dahl Salt-Sensitive (SS) Rats. Hypertension. 54; e63, 2009. | 2009 |
| Lu D, Fu Y, Lopez-Ruiz A, Zhang R, Juncos R, Manning RD Jr., Juncos LA, Liu R. Splice variants of nNOS expressed in the macula densa and their variations during high salt intake. Hypertension. 52; e27, 2009. | 2009 |
| Lin L, Phillips WE, Manning RD Jr. The intrarenal angiotensin system and inflammation in Dahl salt-sensitive hypertension FASEB J. 2009; 23: 606.4 [Meeting Abstract] | 2009 |
| Gu J-W, Young E, Lin L, Busby B, Covington J, Manning RD Jr. Nitric Oxide Mediates the Acute Effect of VEGF Infusion on Lowering Blood Pressure in Dahl Salt-Sensitive (SS) Rats Hypertension 2008; 52: e118 | 2008 |
| Manning RD Jr., Tian N, Moore RS, Pryor JS , Stockstill R. Role of Renal NAD(P)H Oxidase in Dahl Salt-Sensitive Hypertension FASEB J. 2008;22:969.1 | 2008 |
| Tian N, Moore RS, Braddy SJ, Manning RD Jr Immune Antioxidant Treatment Improves Renal Inflammation in Dahl Salt-Sensitive Hypertension FASEB J.2007; 21: A590-A591 | 2007 |
Book Chapter | |
| Renal Hypertension. In: Lang. Encyclopedia of Molecular Mechanisms of Disease. Springer-Verlag GmbH. Heidelberg. 2009. | 2009 |
Presentations
| UMC Medical School Prospective Student Career Fair, Cardiac Physiology, UMC Medical School Prospective Student Career Fair, UMC | 03/2011 |
| Poster Presentation, The intrarenal angiotensin system and inflammation in Dahl salt-sensitive hypertension, Experimental Biology 2009, New Orleans, LA | 04/2009 |
| Poster Presentation, . Role of Renal NAD(P)H Oxidase in Dahl Salt-Sensitive Hypertension, Experimental Biology 2008, San Diego, CA | 04/2008 |
| Poster Presentation, Immune Antioxidant Treatment Improves Renal Inflammation in Dahl Salt-Sensitive Hypertension, Experimental Biology 2007, Washington, DC | 04/2007 |
Honors, Awards, and Recognition
| Medical School Honor Council Faculty Advisor, Medical School Honor Council | 2009 |
| University of Mississippi School of Medicine Representative for the review of the MCAT Science Content by the AAMC., AAMC | 2009 |
| University of MS Medical School Evers Society Hall of Fame, 2004 | 2004 |
| Blake Academy of Teaching Excellence at the University of MS Medical School, 2003 | 2003 |
| University of MS Medical School Top Five Basic Science teachers (Evers Society Award), UMC Evers Society | 2002 |
| University of MS Medical School Top Five Basic Science teachers (Evers Society Award), UMC Evers Society | 2001 |
| University of MS Medical School Top Five Basic Science teachers (Evers Society Award), UMC Evers Society | 2000 |
| University of MS Medical School Top Five Basic Science teachers (Evers Society Award), Evers Society | 1999 |
| University of MS Medical School Top Five Basic Science teachers (Evers Society Award), UMC Evers Society | 1998 |
| Harry Goldblatt Award Council for High Blood Pressure Research of The American Heart Association, American Heart Association | 1995 |
| Omicron Delta Kappa | 1967 |
Committee Service
| School Of Medicine - Promotions (Basic Science), Member | 2010 - 2012 |
| LCME Self Study Committee, Member | 2010 - 2011 |
| School Of Medicine - Curriculum, Member | 2004 - 2011 |
Other Service
| Family Day (for Incoming Medical Student families), Speaker | 08/2011 - 08/2011 |
| LCME Medical School Educational Standards Subcommittee, member | 09/2010 - 2011 |
| 11/2009 - Present |
Teaching Experience
| Medicine, Small Group, Course Presenter, Medical Physiology | Spring 2014 |
| Medicine, Course, Course Presenter, Medical Physiology | Spring 2014 |
| Medicine, Course, Course Presenter, Medical Physiology | Spring 2013 - 2013 |
| Medicine, Small Group, Course Presenter | Spring 2013 |
| 611, Medicine, Course, Course Presenter, Meical Physiology | Spring 2012 |
| 001, Medicine, Lecture, Guest Presenter, M2 Step 1 Preparation | Spring 2012 |
| 611, Medicine, Small Group, Course Presenter, Medical Physiology | Spring 2012 |
| 611, Medicine, Course, Course Presenter, Medical Physiology | Spring 2011 |
| 611, Medicine, Small Group, Course Presenter, Medical Physiology | Spring 2011 |
| 611, Medicine, Course, Course Presenter, Medical physiology | Spring 2010 |
| 611, Medicine, Small Group, Course Presenter, Medical Physiology | Spring 2010 |
| 001, Medicine, Lecture, Guest Presenter, M2 STEP 1 preparation | Spring 2010 |
| Medicine, Lecture, Guest Presenter, NA | Spring 2010 |
| 611, Medicine, Course, Course Presenter, Medical physiology | Winter 2009 |
| 611, Medicine, Small Group, Course Presenter, Medical Physiology | Winter 2009 |
| 717, Graduate, Lecture, Course Presenter, Circulatory Physiology | Fall 2009 |
| 611, Medicine, Lecture, Course Presenter, Medical Physiology | Winter 2008 |
| 611, Medicine, Small Group, Course Presenter, Medical Physiology | Winter 2008 |
| 717, Graduate, Lecture, Course Presenter, Circulatory Physiology | Fall 2007 |
| 611, Medicine, Small Group, Course Presenter, Medical Physiology | Winter 2007 |
| 611, Medicine, Lecture, Course Presenter, Medical Physiology | Winter 2007 |
Fellows supervised
| Postdoctoral Fellowship, Training Faculty, 1 fellows supervised, Lin Lin, M.D. | 12/2007 - Present |