Nita J. Maihle

Affiliate Faculty

Department:
SOM-Medicine

Email:
nmaihle@umc.edu

Work Phone:
(601) 984-5350

Biography

Dr. Nita Maihle is an experienced cancer biologist who has devoted her career to developing a better understanding of what causes cancer, and to applying this information to improved methods for the early detection, prevention, and treatment of cancer. Over the past three decades, Dr. Maihle and her colleagues have discovered that the signals that cause cancer cells to grow are different from the signals that cause normal cells to grow. These “short circuits” in cancer cells can be targeted to specifically stop cancer cells from growing. New drugs targeting these cancer cell short circuits, drugs such as Herceptin and Gleevec, are some of the most cutting-edge, effective, and specific agents used in the treatment of cancer patients today. Studies in Dr. Maihle’s laboratory are focused on the discovery of disruptive innovations in the rapidly emerging field of precision medicine: innovations that will allow the more efficient coupling of these new, biologically-targeted therapeutics to the right cancer patients, through the development and application of biochemical and molecular diagnostics.

These short circuits in cancer cells result in a molecular signature that is unique to the cancer cell. Dr. Maihle’s laboratory has developed exquisitely sensitive biochemical assays that may one day be useful in detecting cancer cells anywhere in the body using a simple blood test to detect a tumor long before it is clinically detectable. Such early detection would allow even currently available treatments to be more effective— alleviating much human suffering. Dr. Maihle is strongly committed to the clinical translation of these basic research discoveries.

In addition, Dr. Maihle has served as a mentor and role model for many successful students, residents, fellows, and visiting professors, and has been particularly active as an advocate for women and other underrepresented individuals in the biomedical sciences. She serves in a leadership capacity for numerous interdisciplinary cancer research organizations throughout the country, and also for several national research funding organizations.

Education

Yale University, MA, Medicine	2005
Case Western Reserve School of Medicine, Postdoc Fellowship, Tumor Biology	1989
Cold Spring Harbor Laboratory, Postdoc Fellowship, Tumor Virology	1984
NCI-FCRF, Postdoc Fellowship, Tumor Virology	1984
Albert Einstein College of Medicine, PhD, Biomedical Sciences	1983
Albert Einstein College of Medicine, MS, Biomedical Sciences	1981
Miami University, MS, Biology	1977
Miami University, BA, Biology/Botany	1976

Current Positions

Professor, School of Medicine	10/2019 - Present
The University of Mississippi Medical Center Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Professor, Medical College of Georgia, School of Medicine, Department of Biochemistry	08/2013 - 09/2018
Professor, Yale University, School of Medicine, Department of Pathology	08/2003 - 07/2013
Professor, Mayo Clinic, School of Medicine	07/1999 - 07/2003
Associate Professor, Mayo Clinic, School of Medicine, Department of Biochemistry	07/1993 - 06/1999
Assistant Professor, Mayo Clinic, School of Medicine, Department of Biochemistry	04/1989 - 06/1993

Publications

Letter
Reiter JL, Maihle NJ, Clinton GM, Therapeutic potential of epidermal growth factor receptor-related protein. Molecular cancer therapeutics, 2006 Nov;5(11):2954; author reply 2955	2006
Reiter JL, Eley G, James CD, Maihle NJ, Correspondence re: S. Shintani et al., Intragenic mutation analysis of the human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes. Cancer Res., 59: 4142-4147, 1999. Cancer research, 2000 Feb 1;60(3):766-7	2000
News
Maihle NJ, Lafky JM, Receptor tails and transcriptional regulation. Trends in cell biology, 2002 Apr;12(4):160-1	2002
Journal Article
Gibert, Y and Maihle, NJ Agnostic Cancer Immunotherapy: Fact of Fiction? Endocrinology and Metabolic Res. SI.02-01-02; 2020	2020
Zhou YY, Simmons J, Jordan CD, Sonbol MB, Maihle NJ, and Tang SC Aspirin Treatment Effect and Association with PIK3CA Mutation in Breast Cancer: A Retrospective Analysis. Clinical Breast Cancer* Clin Breast Cancer. 19(5):354-362.37. 2019	2019
Maihle NJ, Levine DA, Dhillon K, Armstrong DK Introduction: The 12th Biennial Rivkin Center Ovarian Cancer Research Symposium Int J Gyn Cancer. 29(2); 2019	2019
Eisa N, Jilani K, Kashish K, Redd P, Lu S, Bougrine O, Sater H, Patwardha C, Shull A, Shi H, Horuzsko A, Lui K, Elsherbiny N, Eissa L, Mamdouh M, Horuzsko A, Bollag M, Maihle NJ, Roig J, Korkaya H, Chadli A The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis* J Biol Chem, 294(14): 5246-5260; 2019	2019
Yu X, Ghamande S, Liu H, Xue L, Zhao S, Tan W, Zhao L, Tang S, Wu D, Korkaya, H, Maihle NJ, Liu, H-Y Targeting EGFR/HER2/HER3 with Three-in-One aptamer/siRNA chimera confers superior anti-tumor activity in HER2 positive breast cancer Molecular Therapeutics Nucl Acids; 10:317-330; 2018	2018
Xue L, Maihle NJ, Yu X, Tang SC, Liu HY, Synergistic Targeting HER2 and EGFR with Bivalent Aptamer-siRNA Chimera Efficiently Inhibits HER2-Positive Tumor Growth. Molecular pharmaceutics, 2018 Nov 5;15(11):4801-4813	2018
Yu X, Ghamande S, Liu H, Xue L, Zhao S, Tan W, Zhao L, Tang SC, Wu D, Korkaya H, Maihle NJ, Liu HY, Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2(+) Breast Cancer. Molecular therapy. Nucleic acids, 2018 Mar 2;10:317-330	2018
Zhong T, Men Y, Lu L, Geng T, Zhou J, Mitsuhashi A, Shozu M, Maihle NJ, Carmichael GG, Taylor HS, Huang Y, Metformin alters DNA methylation genome-wide via the H19/SAHH axis. Oncogene, 2017 Apr 27;36(17):2345-2354	2017
Sadek I, Keaton M, Maihle NJ, Tang SC, Anti-HER-2 therapy following severe trastuzumab-induced cardiac toxicity. Genes & diseases, 2017 Sep;4(3):159-162	2017
Zhang L, Wang Y, Rashid MH, Liu M, Angara K, Mivechi NF, Maihle NJ, Arbab AS, Ko L, Malignant pericytes expressing GT198 give rise to tumor cells through angiogenesis. Oncotarget, 2017 Aug 1;8(31):51591-51607	2017
Pace BS, Makala LH, Sarkar R, Liu L, Takezaki M, Mohandas N, Dixon G, Werner EM, Jeffe DB, Rice TK, Maihle NJ, González J, Enhancing diversity in the hematology biomedical research workforce: A mentoring program to improve the odds of career success for early stage investigators. American journal of hematology, 2017 Dec;92(12):1275-1279	2017
Yang Z, Peng M, Cheng L, Jones K, Maihle NJ, Mivechi NF, Ko L, GT198 Expression Defines Mutant Tumor Stroma in Human Breast Cancer. The American journal of pathology, 2016 May;186(5):1340-50	2016
Boyington JE, Maihle NJ, Rice TK, Gonzalez JE, Hess CA, Makala LH, Jeffe DB, Ogedegbe G, Rao DC, Dávila-Román VG, Pace BS, Jean-Louis G, Boutjdir M, A Perspective on Promoting Diversity in the Biomedical Research Workforce: The National Heart, Lung, and Blood Institute's PRIDE Program. Ethnicity & disease, 2016 Jul 21;26(3):379-86	2016
Jacobson RS, Becich MJ, Bollag RJ, Chavan G, Corrigan J, Dhir R, Feldman MD, Gaudioso C, Legowski E, Maihle NJ, Mitchell K, Murphy M, Sakthivel M, Tseytlin E, Weaver J, A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens. Cancer research, 2015 Dec 15;75(24):5194-201	2015
Armant DR, Fritz R, Kilburn BA, Kim YM, Nien JK, Maihle NJ, Romero R, Leach RE, Reduced expression of the epidermal growth factor signaling system in preeclampsia. Placenta, 2015 Mar;36(3):270-8	2015
Teoh JP, Park KM, Wang Y, Hu Q, Kim S, Wu G, Huang S, Maihle N, Kim IM, Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis. Cellular signalling, 2014 Dec;26(12):2885-95	2014
Brücher BL, Lyman G, van Hillegersberg R, Pollock RE, Lordick F, Yang HK, Ushijima T, Yeoh KG, Skricka T, Polkowski W, Wallner G, Verwaal V, Garofalo A, D'Ugo D, Roviello F, Steinau HU, Wallace TJ, Daumer M, Maihle N, Reid TJ 3rd, Ducreux M, Kitagawa Y, Knuth A, Zilberstein B, Steele SR, Jamall IS, Imagine a world without cancer. BMC cancer, 2014 Mar 14;14:186	2014
Wilken JA, Perez-Torres M, Nieves-Alicea R, Cora EM, Christensen TA, Baron AT, Maihle NJ, Shedding of soluble epidermal growth factor receptor (sEGFR) is mediated by a metalloprotease/fibronectin/integrin axis and inhibited by cetuximab. Biochemistry, 2013 Jul 2;52(26):4531-40	2013
Ma W, Ma J, Xu J, Qiao C, Branscum A, Cardenas A, Baron AT, Schwartz P, Maihle NJ, Huang Y, Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment. Cell cycle (Georgetown, Tex.), 2013 Jan 1;12(1):88-97	2013
Cosentino-Boehm AL, Lafky JM, Greenwood TM, Kimbler KD, Buenafe MC, Wang Y, Branscum AJ, Yang P, Maihle NJ, Baron AT, Soluble Human Epidermal Growth Factor Receptor 2 (sHER2) as a Potential Risk Assessment, Screening, and Diagnostic Biomarker of Lung Adenocarcinoma. Diagnostics (Basel, Switzerland), 2013 Jan 14;3(1):13-32	2013
Feng C, Neumeister V, Ma W, Xu J, Lu L, Bordeaux J, Maihle NJ, Rimm DL, Huang Y, Lin28 regulates HER2 and promotes malignancy through multiple mechanisms. Cell cycle (Georgetown, Tex.), 2012 Jul 1;11(13):2486-94	2012
Wilken JA, Badri T, Cross S, Raji R, Santin AD, Schwartz P, Branscum AJ, Baron AT, Sakhitab AI, Maihle NJ, EGFR/HER-targeted therapeutics in ovarian cancer. Future medicinal chemistry, 2012 Mar;4(4):447-69	2012
Wilken JA, Baron AT, Foty RA, McCormick DJ, Maihle NJ, Identification of immunoreactive regions of homology between soluble epidermal growth factor receptor and α5-integrin. Biochemistry, 2011 May 24;50(20):4309-21	2011
Wilken JA, Maihle NJ, Primary trastuzumab resistance: new tricks for an old drug. Annals of the New York Academy of Sciences, 2010 Oct;1210:53-65	2010
Albitar L, Pickett G, Morgan M, Wilken JA, Maihle NJ, Leslie KK, EGFR isoforms and gene regulation in human endometrial cancer cells. Molecular cancer, 2010 Jun 25;9:166	2010
Wilken JA, Webster KT, Maihle NJ, Trastuzumab Sensitizes Ovarian Cancer Cells to EGFR-targeted Therapeutics. Journal of ovarian research, 2010 Mar 27;3:7	2010
Peng S, Maihle NJ, Huang Y, Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. Oncogene, 2010 Apr 8;29(14):2153-9	2010
Baron AT, Wilken JA, Haggstrom DE, Goodrich ST, Maihle NJ, Clinical implementation of soluble EGFR (sEGFR) as a theragnostic serum biomarker of breast, lung and ovarian cancer. IDrugs : the investigational drugs journal, 2009 May;12(5):302-8	2009
Perez-Torres M, Valle BL, Maihle NJ, Negron-Vega L, Nieves-Alicea R, Cora EM, Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells. Experimental cell research, 2008 Oct 1;314(16):2907-18	2008
Lafky JM, Wilken JA, Baron AT, Maihle NJ, Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. Biochimica et biophysica acta, 2008 Apr;1785(2):232-65	2008
Fisher MC, Clinton GM, Maihle NJ, Dealy CN, Requirement for ErbB2/ErbB signaling in developing cartilage and bone. Development, growth & differentiation, 2007 Aug;49(6):503-13	2007
Cleary MP, Hu X, Grossmann ME, Juneja SC, Dogan S, Grande JP, Maihle NJ, Prevention of mammary tumorigenesis by intermittent caloric restriction: does caloric intake during refeeding modulate the response? Experimental biology and medicine (Maywood, N.J.), 2007 Jan;232(1):70-80	2007
Jones MB, Houwink AP, Freeman BK, Greenwood TM, Lafky JM, Lingle WL, Berchuck A, Maxwell GL, Podratz KC, Maihle NJ, The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer. Journal of the Society for Gynecologic Investigation, 2006 May;13(4):304-11	2006
Lafky JM, Baron AT, Cora EM, Hillman DW, Suman VJ, Perez EA, Ingle JN, Maihle NJ, Serum soluble epidermal growth factor receptor concentrations decrease in postmenopausal metastatic breast cancer patients treated with letrozole. Cancer research, 2005 Apr 15;65(8):3059-62	2005
Omi M, Fisher M, Maihle NJ, Dealy CN, Studies on epidermal growth factor receptor signaling in vertebrate limb patterning. Developmental dynamics : an official publication of the American Association of Anatomists, 2005 Jun;233(2):288-300	2005
Baron AT, Boardman CH, Lafky JM, Rademaker A, Liu D, Fishman DA, Podratz KC, Maihle NJ, Soluble epidermal growth factor receptor (sEGFR) [corrected] and cancer antigen 125 (CA125) as screening and diagnostic tests for epithelial ovarian cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005 Feb;14(2):306-18	2005
Cleary MP, Grande JP, Maihle NJ, Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-alpha mice. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2004 Aug;28(8):956-62	2004
Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP, Maihle NJ, Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Experimental biology and medicine (Maywood, N.J.), 2004 Feb;229(2):182-93	2004
Bostwick DG, Qian J, Maihle NJ, Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 93 cases. The Prostate, 2004 Feb 1;58(2):164-8	2004
Danielsen AJ, Christensen TA, Lovejoy CA, Adelsman MA, Connolly DC, Maihle NJ, Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation. Experimental cell research, 2004 Jun 10;296(2):285-93	2004
Baron AT, Cora EM, Lafky JM, Boardman CH, Buenafe MC, Rademaker A, Liu D, Fishman DA, Podratz KC, Maihle NJ, Soluble epidermal growth factor receptor (sEGFR/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003 Feb;12(2):103-13	2003
Boerner JL, Danielsen AJ, Lovejoy CA, Wang Z, Juneja SC, Faupel-Badger JM, Darce JR, Maihle NJ, Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis. Oncogene, 2003 Oct 2;22(43):6679-89	2003
Modugno F, Ovarian Cancer and High-Risk Women Symposium Presenters, Ovarian cancer and high-risk women-implications for prevention, screening, and early detection. Gynecologic oncology, 2003 Oct;91(1):15-31	2003
Reiter J, Maihle NJ, Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta. Annals of the New York Academy of Sciences, 2003 May;995:39-47	2003
Boerner JL, Danielsen A, Maihle NJ, Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm. Experimental cell research, 2003 Mar 10;284(1):111-21	2003
Cleary MP, Phillips FC, Getzin SC, Jacobson TL, Jacobson MK, Christensen TA, Juneja SC, Grande JP, Maihle NJ, Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast cancer research and treatment, 2003 Feb;77(3):205-15	2003
Hu X, Juneja SC, Maihle NJ, Cleary MP, Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development. Journal of the National Cancer Institute, 2002 Nov 20;94(22):1704-11	2002
Cleary MP, Jacobson MK, Phillips FC, Getzin SC, Grande JP, Maihle NJ, Weight-cycling decreases incidence and increases latency of mammary tumors to a greater extent than does chronic caloric restriction in mouse mammary tumor virus-transforming growth factor-alpha female mice. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002 Sep;11(9):836-43	2002
Christensen TA, Reiter JL, Baron AT, Maihle NJ, Generation and characterization of polyclonal antibodies specific for human p110 sEGFR. Hybridoma and hybridomics, 2002 Jun;21(3):183-9	2002
Danielsen AJ, Maihle NJ, The EGF/ErbB receptor family and apoptosis. Growth factors (Chur, Switzerland), 2002 Mar;20(1):1-15	2002
Eley GD, Reiter JL, Pandita A, Park S, Jenkins RB, Maihle NJ, James CD, A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma. Neuro-oncology, 2002 Apr;4(2):86-94	2002
Danielsen AJ, Maihle NJ, Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity. Experimental cell research, 2002 Apr 15;275(1):9-16	2002
Baron AT, Lafky JM, Suman VJ, Hillman DW, Buenafe MC, Boardman CH, Podratz KC, Perez EA, Maihle NJ, A preliminary study of serum concentrations of soluble epidermal growth factor receptor (sErbB1), gonadotropins, and steroid hormones in healthy men and women. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001 Nov;10(11):1175-85	2001
Lee H, Akita RW, Sliwkowski MX, Maihle NJ, A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4. Cancer research, 2001 Jun 1;61(11):4467-73	2001
Boerner JL, Danielsen A, McManus MJ, Maihle NJ, Activation of Rho is required for ligand-independent oncogenic signaling by a mutant epidermal growth factor receptor. The Journal of biological chemistry, 2001 Feb 2;276(5):3691-5	2001
Reiter JL, Threadgill DW, Eley GD, Strunk KE, Danielsen AJ, Sinclair CS, Pearsall RS, Green PJ, Yee D, Lampland AL, Balasubramaniam S, Crossley TD, Magnuson TR, James CD, Maihle NJ, Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms. Genomics, 2001 Jan 1;71(1):1-20	2001
McManus MJ, Boerner JL, Danielsen AJ, Wang Z, Matsumura F, Maihle NJ, An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex. The Journal of biological chemistry, 2000 Nov 10;275(45):35328-34	2000
Boerner JL, McManus MJ, Martin GS, Maihle NJ, Ras-independent oncogenic transformation by an EGF-receptor mutant. Journal of cell science, 2000 Mar;113 ( Pt 6):935-42	2000
Wang Z, Danielsen AJ, Maihle NJ, McManus MJ, Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex. The Journal of biological chemistry, 1999 Nov 19;274(47):33807-13	1999
Baron AT, Lafky JM, Boardman CH, Balasubramaniam S, Suman VJ, Podratz KC, Maihle NJ, Serum sErbB1 and epidermal growth factor levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999 Feb;8(2):129-37	1999
Baron AT, Lafky JM, Connolly DC, Peoples J, O'Kane DJ, Suman VJ, Boardman CH, Podratz KC, Maihle NJ, A sandwich type acridinium-linked immunosorbent assay (ALISA) detects soluble ErbB1 (sErbB1) in normal human sera. Journal of immunological methods, 1998 Oct 1;219(1-2):23-43	1998
Lee H, Maihle NJ, Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues. Oncogene, 1998 Jun 25;16(25):3243-52	1998
Lingle WL, Lutz WH, Ingle JN, Maihle NJ, Salisbury JL, Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proceedings of the National Academy of Sciences of the United States of America, 1998 Mar 17;95(6):2950-5	1998
Cleary MP, Maihle NJ, The role of body mass index in the relative risk of developing premenopausal versus postmenopausal breast cancer. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1997 Oct;216(1):28-43	1997
McManus MJ, Lingle WL, Salisbury JL, Maihle NJ, A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly. Proceedings of the National Academy of Sciences of the United States of America, 1997 Oct 14;94(21):11351-6	1997
Baron AT, Huntley BK, Lafky JM, Reiter JL, Liebenow J, McCormick DJ, Ziesmer SC, Roche PC, Maihle NJ, Monoclonal antibodies specific for peptide epitopes of the epidermal growth factor receptor's extracellular domain. Hybridoma, 1997 Jun;16(3):259-71	1997
Reiter JL, Maihle NJ, A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor. Nucleic acids research, 1996 Oct 15;24(20):4050-6	1996
Adelsman MA, Huntley BK, Maihle NJ, Ligand-independent dimerization of oncogenic v-erbB products involves covalent interactions. Journal of virology, 1996 Apr;70(4):2533-44	1996
Gill JS, Connolly DC, McManus MJ, Maihle NJ, Windebank AJ, Suramin induces phosphorylation of the high-affinity nerve growth factor receptor in PC12 cells and dorsal root ganglion neurons. Journal of neurochemistry, 1996 Mar;66(3):963-72	1996
McManus MJ, Connolly DC, Maihle NJ, Tissue- and transformation-specific phosphotyrosyl proteins in v-erbB-transformed cells. Journal of virology, 1995 Jun;69(6):3631-8	1995
Connolly DC, Toutenhoofd SL, Maihle NJ, Tyrosine kinase activity may be necessary but is not sufficient for c-erbB1-mediated tissue-specific tumorigenicity. Journal of virology, 1994 Oct;68(10):6804-10	1994
Eldredge ER, Korf GM, Christensen TA, Connolly DC, Getz MJ, Maihle NJ, Activation of c-fos gene expression by a kinase-deficient epidermal growth factor receptor. Molecular and cellular biology, 1994 Nov;14(11):7527-34	1994
Sehgal I, Powers S, Huntley B, Powis G, Pittelkow M, Maihle NJ, Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 1994 May 24;91(11):4673-7	1994
Bonner JA, Maihle NJ, Folven BR, Christianson TJ, Spain K, The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities. International journal of radiation oncology, biology, physics, 1994 May 15;29(2):243-7	1994
Sehgal I, Bailey J, Hitzemann K, Pittelkow MR, Maihle NJ, Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells. Molecular biology of the cell, 1994 Mar;5(3):339-47	1994
Bell SM, Connolly DC, Maihle NJ, Degen JL, Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases. Molecular and cellular biology, 1993 Sep;13(9):5888-97	1993
Lust JA, Donovan KA, Kline MP, Greipp PR, Kyle RA, Maihle NJ, Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine, 1992 Mar;4(2):96-100	1992
Flickinger TW, Maihle NJ, Kung HJ, An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation. Molecular and cellular biology, 1992 Feb;12(2):883-93	1992
Maihle NJ, Flickinger TW, Raines MA, Sanders ML, Kung HJ, Native avian c-erbB gene expresses a secreted protein product corresponding to the ligand-binding domain of the receptor. Proceedings of the National Academy of Sciences of the United States of America, 1991 Mar 1;88(5):1825-9	1991
Schowalter DB, Sullivan WP, Maihle NJ, Dobson AD, Conneely OM, O'Malley BW, Toft DO, Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins. The Journal of biological chemistry, 1991 Nov 5;266(31):21165-73	1991
Ranganathan G, Blatti SP, Subramaniam M, Fass DN, Maihle NJ, Getz MJ, Cloning of murine tissue factor and regulation of gene expression by transforming growth factor type beta 1. The Journal of biological chemistry, 1991 Jan 5;266(1):496-501	1991
Forry-Schaudies S, Maihle NJ, Hughes SH, Generation of skeletal, smooth and low molecular weight non-muscle tropomyosin isoforms from the chicken tropomyosin 1 gene. Journal of molecular biology, 1990 Jan 20;211(2):321-30	1990
Pelley RJ, Maihle NJ, Boerkoel C, Shu HK, Carter TH, Moscovici C, Kung HJ, Disease tropism of c-erbB: effects of carboxyl-terminal tyrosine and internal mutations on tissue-specific transformation. Proceedings of the National Academy of Sciences of the United States of America, 1989 Sep;86(18):7164-8	1989
Maihle NJ, Kung HJ, C-erbB and the epidermal growth-factor receptor: a molecule with dual identity. Biochimica et biophysica acta, 1989 Feb;948(3):287-304	1989
Maihle NJ, Raines MA, Flickinger TW, Kung HJ, Proviral insertional activation of c-erbB: differential processing of the protein products arising from two alternate transcripts. Molecular and cellular biology, 1988 Nov;8(11):4868-76	1988
Raines MA, Maihle NJ, Moscovici C, Crittenden L, Kung HJ, Mechanism of c-erbB transduction: newly released transducing viruses retain poly(A) tracts of erbB transcripts and encode C-terminally intact erbB proteins. Journal of virology, 1988 Jul;62(7):2437-43	1988
Raines MA, Maihle NJ, Moscovici C, Moscovici MG, Kung HJ, Molecular characterization of three erbB transducing viruses generated during avian leukosis virus-induced erythroleukemia: extensive internal deletion near the kinase domain activates the fibrosarcoma- and hemangioma-inducing potentials of erbB. Journal of virology, 1988 Jul;62(7):2444-52	1988
Maihle NJ, Satir BH, Protein secretion in Tetrahymena thermophila. Characterization of the major proteinaceous secretory proteins. The Journal of biological chemistry, 1986 Jun 5;261(16):7566-70	1986
Maihle NJ, Satir BH, Protein secretion in Tetrahymena thermophila: characterization of the secretory mutant strain SB281. Journal of cell science, 1985 Oct;78:49-65	1985
Salisbury JL, Condeelis JS, Maihle NJ, Satir P, Calmodulin localization during capping and receptor-mediated endocytosis. Nature, 1981 Nov 12;294(5837):163-6	1981
Maihle NJ, Dedman JR, Means AR, Chafouleas JG, Satir BH, Presence and indirect immunofluorescent localization of calmodulin in Paramecium tetraurelia. The Journal of cell biology, 1981 Jun;89(3):695-9	1981
NITA J. MAIHLE and WILL H. BLACKWELL, JR. A SYNOPSIS OF NORTH AMERICAN CORISPERMUM (CHENOPODIACEAE) SIDA, Contributions to Botany Vol. 7, No. 4 (DECEMBER 1978), pp. 382-391
Shepard JB, Jeong JW, Maihle NJ, O'Brien S, Dealy CN, Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo. Arthritis research & therapy, 2013;15(3):R60
Rodland KD, Maihle NJ, Searching for a system: the quest for ovarian cancer biomarkers. Cancer biomarkers : section A of Disease markers, 2010-2011;8(4-5):223-30
Baron AT, Lafky JM, Boardman CH, Cora EM, Buenafe MC, Liu D, Rademaker A, Fishman DA, Podratz KC, Reiter JL, Maihle NJ, Soluble epidermal growth factor receptor: a biomarker of epithelial ovarian cancer. Cancer treatment and research, 2009;149:189-202
Dogan S, Hu X, Zhang Y, Maihle NJ, Grande JP, Cleary MP, Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha mice. Breast cancer research : BCR, 2007;9(6):R91
Lafky JM, Baron AT, Maihle NJ, Soluble epidermal growth factor receptor acridinium-linked immunosorbent assay. Methods in molecular biology (Clifton, N.J.), 2006;327:39-47
Cleary MP, Grande JP, Juneja SC, Maihle NJ, Diet-induced obesity and mammary tumor development in MMTV-neu female mice. Nutrition and cancer, 2004;50(2):174-80
Pape-Ansorge KA, Grande JP, Christensen TA, Maihle NJ, Cleary MP, Effect of moderate caloric restriction and/or weight cycling on mammary tumor incidence and latency in MMTV-Neu female mice. Nutrition and cancer, 2002;44(2):162-8
Maihle NJ, Baron AT, Barrette BA, Boardman CH, Christensen TA, Cora EM, Faupel-Badger JM, Greenwood T, Juneja SC, Lafky JM, Lee H, Reiter JL, Podratz KC, EGF/ErbB receptor family in ovarian cancer. Cancer treatment and research, 2002;107:247-58
McManus MJ, Hutt PJ, Maihle NJ, Phosphotyrosyl proteins in childhood rhabdomyosarcomas: phosphorylation of catenins and components of the insulin-like growth factor type I receptor signaling cascade. Journal of pediatric hematology/oncology, 1997 Jul-Aug;19(4):319-26
Lust JA, Jelinek DF, Donovan KA, Frederick LA, Huntley BK, Braaten JK, Maihle NJ, Sequence, expression and function of an mRNA encoding a soluble form of the human interleukin-6 receptor (sIL-6R). Current topics in microbiology and immunology, 1995;194:199-206
Maihle NJ, Satir BH, Identification of a biochemical marker for the secretory pathway in Tetrahymena thermophila. Journal of cellular biochemistry, 1986;31(3):195-202
Salisbury JL, Condeelis JS, Maihle NJ, Satir P, Receptor-mediated endocytosis by clathrin-coated vesicles: evidence for a dynamic pathway. Cold Spring Harbor symposia on quantitative biology, 1982;46 Pt 2:733-41
Maihle NJ, Satir BH, Calmodulin in the ciliates Paramecium tetraurelia and Tetrahymena thermophila. Annals of the New York Academy of Sciences, 1980;356:408-9
Satir BH, Garofalo RS, Gilligan DM, Maihle NJ, Possible functions of calmodulin in protozoa. Annals of the New York Academy of Sciences, 1980;356:83-91
Abstracts
Taylor, Thomas N, Maihle, Nita J, Hills, Len V Morphological and ultrastructural features of Nikitinsporites canadensis chaloner, a devonian megaspore from the frasnian of canada Review of Palaeobotany and Palynology Volume 30, 1980, Pages 89-99
H.-J. Kung N. J. Maihle Molecular Basis of Oncogenesis by Non-Acute Avian Retroviruses In: De Boer G.F. (eds) Avian Leukosis. Developments in Veterinary Virology, vol 4. Springer, Boston, MA
Salisbury, J.L., Swanson, J.A., Floyd, G.L., Maihle, NJ Ultrastructure of the flagellar apparatus of the green algaTetraselmis subcordiformis Protoplasma March 1981, Volume 107, Issue 1–2, pp 1–11
Nita J. Maihle, Jacqueline M. Lafky, Andre T. Baron, Cecelia H. Boardman, Tammy M. Greenwood, Trace A. Christensen, Jill L. Reiter, Elsa M. Cora, Hakjoo Lee, Vera Jean Suman, David A. Fishman, Edith A. Perez, Karl C. Podratz EGF receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer Journal of Clinical Ligand Assay Volume 25 Pages 57-60 Published - Mar 2002
Kimberly Leslie, Michael Sill, Kathleen Darcy, Andre Baron, Jason Wilken, Andrew Godwin, Linda Cook, Russell Schilder, Jeanne Schilder and Nita Maihle Abstract #LB-134: Prognostic value of serum sEGFR and EGFR mutations in a phase II trial of gefitinib (Iressa®, ZD1839) in women with endometrial cancer AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO
Book Chapter
Maihle NJ Cell Receptors Encyclopedia of Human Biology Volume 2 Pages 557-560
Lafky JM, Greenwood TM, Baron AT, Boardman CH, Cora EM, Maihle NJ Soluble ErbB Receptors [sEGFR/sErbBs]: Serum Biomarkers in Breast and Ovarian Cancer Tumor Markers: Physiology, Pathobiology, Technology and Clinical Applications Chapter 37 Pages 427-431
Clinical Trial
Perez EA, Geeraerts L, Suman VJ, Adjei AA, Baron AT, Hatfield AK, Maihle N, Michalak JC, Kuross SA, Kugler JW, Lafky JM, Ingle JN, A randomized phase II study of sequential docetaxel and doxorubicin/cyclophosphamide in patients with metastatic breast cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 2002 Aug;13(8):1225-35	2002
Bostwick DG, Shan A, Qian J, Darson M, Maihle NJ, Jenkins RB, Cheng L, Independent origin of multiple foci of prostatic intraepithelial neoplasia: comparison with matched foci of prostate carcinoma. Cancer, 1998 Nov 1;83(9):1995-2002	1998
Hartmann LC, Ingle JN, Wold LE, Farr GH Jr, Grill JP, Su JQ, Maihle NJ, Krook JE, Witzig TE, Roche PC, Prognostic value of c-erbB2 overexpression in axillary lymph node positive breast cancer. Results from a randomized adjuvant treatment protocol. Cancer, 1994 Dec 1;74(11):2956-63	1994
Comment
Baron AT, Maihle N, Nadir CA125 concentration as a prognostic indicator in ovarian cancer. Nature clinical practice. Oncology, 2005 Jun;2(6):288-9	2005
Editorial
Wilken JA, Baron AT, Maihle NJ, The epidermal growth factor receptor conundrum. Cancer, 2011 Jun 1;117(11):2358-60	2011

Presentations

Poster Presentation, Development and characterization of a chimeric siRNA-aptamer with inhibitory activity in HER3+ cells, SGO 50th Annual Meeting, Honolulu, HI	03/2019
State/Local Invited Seminars/Lectures, UMMC, Jackson, MS	06/2018
Regional Invited Seminars/Lectures, UPMC Cancer Center, Pittsburgh, PA	09/2017
State/Local Invited Seminars/Lectures, UCONN Health Sciences Cancer Center, Farmington, CT	08/2017
National and International Invited Seminars/Lectures, ASCB/NSF FRED Program Mentoring Workshop, Seattle, WA	07/2017
Regional Invited Seminars/Lectures, Fred Hutchinson Cancer Center, Seattle, WA	07/2017
Poster Presentation, The function of sHER3, an endogenous inhibitor of neuregulin signaling, is required by tenascin C, ASCO Annual Meeting, Chicago, IL	06/2017
Poster Presentation, PI3K Mutation and Effect of Aspirin Use in Breast Cancer, ASCO Annual Meeting, Chicago, IL	06/2017
Poster Presentation, Determination of Normative Patterns of Gene Expression Levels and Breast Cancer Risk Biomarkers in Human Breast Milk, AACR Annual Meeting, Washington, DC	04/2017
State/Local Invited Seminars/Lectures, KUMC Cancer Center, Kansas City, KS	03/2017
State/Local Invited Seminars/Lectures, UPR Medical Sciences Campus, San Juan, PR	02/2017
Poster Presentation, The RNA-binding protein with multiple splicing (RBPMS) acts as a tumor suppressor in ovarian cancer, ASCB Annual Meeting, San Francisco, CA	12/2016
Poster Presentation, The effect of p85-sHER3 on cancer cell growth and migration: requirement for tenascin-C, ASCB Annual Meeting, San Francisco, CA	12/2016
Poster Presentation, Does rural status impact survival in cervical cancer patients receiving Chemoradiation treated at a single institution?, Georgia Academy of Family Physicians' 2016 Annual Scientific Assembly, Atlanta, GA	10/2016
Poster Presentation, Determining the risk factors for cardiac toxicity in breast cancer patients receiving radiation, ACP Georgia Chapter, Atlanta, GA	09/2016
State/Local Invited Seminars/Lectures, UI Medical Center, Indianapolis, IN	09/2016
State/Local Invited Seminars/Lectures, IU Cancer Center, Bloomington, IN	09/2016
Poster Presentation, The effect of p85-sHER3 on cancer cell growth and migration: requirement for tenascin-C, ISOBM Annual Congress, Chicago, IL	09/2016
Regional Invited Seminars/Lectures, ASCB/NSF FRED Program Mentoring Workshop, Chapel Hill, NC	07/2016
State/Local Invited Seminars/Lectures, 2016 Research Day - Innovation & Biomedical Research: Precision Medicine, USC - Aiken, Aiken, SC	05/2016
Regional Invited Seminars/Lectures, Federated Biospecimen Sharing Facilitated through TIES' (Information Technology for Cancer Research Session), AACR, New Orleans, LA	04/2016
Poster Presentation, The plasma concentration of EGFR and overall survival in NSCLC, Annual ASTRO Meeting, San Antonio, TX	10/2015
Poster Presentation, New method for isoform-specific detection of alternate EGFR isoforms in human placenta demonstrates differential isoform expression across semesters, MCG Medical Scholars Research Day, Augusta, GA	09/2015
Poster Presentation, Changes in circulating EGFR during Radiotherapy in Non-Small Cell Lung Cancer (NSCLC) Patients, International Association for the Study of Lung Cancer, Denver, CO	09/2015
State/Local Invited Seminars/Lectures, Cedars Sinai Cancer Center, Los Angeles, CA	02/2015
State/Local Invited Seminars/Lectures, (for NIH MBRS RISE Program), UPR Medical Sciences Campus, San Juan, PR	02/2015
Poster Presentation, Balancing destructive and regenerative Epidermal Growth Factor Receptor (EGFR) signals in osteoarthritis, Annual Meeting American College of Rheumatology, Boston, MA	11/2014
National and International Invited Seminars/Lectures, Interview Skills - Professional Development Workshop (CABTRAC), CABTRAC, Steamboat Springs, CO	10/2014
National and International Invited Seminars/Lectures, Team-Based Science: How to Build a Successful Translational Research Team - Inaugural Translational Research Workshop, Joint Meeting of the International Congress of Endocrinology and the 96th Annual Meeting of the Endocrine Society (ICE/ENDO 2014), Chicago, IL	06/2014
Corporate Invited Lecture, Regeneron Pharmaceuticals, Tarrytown, NY	05/2014
Poster Presentation, sHER3 inhibits proliferation and migration of melanoma-derived cells in a tenascin-dependent manner, AACR Annual Meeting, San Diego, CA	04/2014
Regional Invited Seminars/Lectures, Center for Cancer Research Grand Rounds, NCI, Bethesda, MD	04/2014
Invited Symposia, International Ovarian Cancer Symposium, Oklahoma City, OK	02/2014
Regional Invited Seminars/Lectures, 'Science of Health Care Disparities' (Komen-sponsored Disparities in Breast Cancer Research Training Program Satellite Conference), AACR/Komen	12/2013
Graduation Lecture, Albert Einstein College of Medicine, Distinguished Alumnus of Year Award Lecturer, Albert Einstein College of Medicine, New York, NY	05/2013
State/Local Invited Seminars/Lectures, University of Kansas Medical Center Grand Rounds, UK Medical Center, Kansas City, KS	04/2013
State/Local Invited Seminars/Lectures, Distinguished Alumni Guest Speaker, Miami University, Oxford, OH	03/2013
Platform Presentations, Precision Medicine: A Vision for the Future of Medicine, Landmark Venture Forum 'Investing for Cures – the Future of Medicine', Landmark Venture Forum, New York, NY	12/2012
State/Local Invited Seminars/Lectures, Medical College of Georgia, Augusta, GA	12/2012
Platform Presentations, Landmark Venture Forum 'Investing for Cures' - Future of Medicine (Panelists: Sherry Snyder, CEO - Genzyme, Stephen Chang, VP - NY Stem Cell Foundation, Nita Maihle - Yale Professor & BOD Member, Loring Biologics, Inc.), Landmark Venture Forum, New York, NY	11/2012
State/Local Invited Seminars/Lectures, University of Pennsylvania, Center for Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA	05/2012
State/Local Invited Seminars/Lectures, University of Iowa Medical School Grand Rounds, UI Medical School, Iowa City, IA	05/2012
National and International Invited Seminars/Lectures, Analogies between HER2 shedding and origin of circulating sEGFR: Serum sEGFR biomarker arises via a fibronectin regulated proteolytic cleavage event, AACR Annual Meeting, Chicago, IL	03/2012
Convocation Speaker, Van Andel Institute Graduate School, Grand Rapids, MI	08/2011
Regional Invited Seminars/Lectures, Speaker, Department of Molecular Genetics and Microbiology, State University of NY, Stony Brook, NY	04/2011
State/Local Invited Seminars/Lectures, Stories of Success - Women in Medicine Symposium, State University of NY, Stony Brook, NY	04/2011
National and International Invited Seminars/Lectures, Diagnostic and prognostic utility of novel EGFR isoforms in cancer patients, AACR Symposium, Philadelphia, PA	11/2010
National and International Invited Seminars/Lectures, Plenary Speaker, Ninth Annual AACR International Conference on Frontiers in Cancer Prevention Research, AACR, Philadelphia, PA	11/2010
Regional Invited Seminars/Lectures, Plenary Speaker, Accelerating Development and Advancing Personalized Therapy: Targeted Cancer Therapy, Arlington, VA	09/2010
Session Chair, Personalized and Translational Medicine Conference, Boston, MA	09/2010
Regional Invited Seminars/Lectures, Molecular and Translational Oncology Workshop Cancer Education Consortium for Post-graduate Education, Sanibel, FL	05/2010
National and International Invited Seminars/Lectures, NCI Stakeholders' Meeting: 'Research Priorities for the Future', NCI, Rockville, MD	05/2010
Poster Presentation, Combined sEGFR and EGFR expression in human tissues reveals the prognostic potential of comprehensive EGFR isoform analysis, AACR Annual Meeting, Washington, DC	04/2010
State/Local Invited Seminars/Lectures, Department of Biological Sciences, St John's University, Queens, NY	04/2010
State/Local Invited Seminars/Lectures, UC Davis Cancer Center, Sacramento CA	03/2010
State/Local Invited Seminars/Lectures, Lenox Hill Hospital, Department of Pathology, Lenox Hill Hospital, NY, NY	12/2009
Regional Invited Seminars/Lectures, Canary Foundation "Lung Cancer Program", Canary Foundation, NY, NY	11/2009
Invited Symposia, University of Cincinnati Medical Center, Cincinnati, OH	09/2009
National and International Invited Seminars/Lectures, Harvard Macy Leadership in Medicine Workshop, Faculty Scholar, Boston, MA	06/2009
Regional Invited Seminars/Lectures, Tina Brozman Foundation for Ovarian Cancer Research, Tina Brozman Foundation, NY, NY	05/2009
State/Local Invited Seminars/Lectures, Molecular Medicine Program, Cornell University, Ithaca, NY	05/2009
State/Local Invited Seminars/Lectures, Molecular and Translational Oncology Workshop Cancer Education Consortium for Post-graduate Education, Greensboro, GA	04/2009
National and International Invited Seminars/Lectures, 'Precision Medicine: The Innovator's Prescription' and "HER2 Diagnostics: Lessons Learned", AACR, Denver, CO	04/2009
Regional Invited Seminars/Lectures, Pfizer Global Research - Women's Leadership Network, Pfizer, Groton, CT	05/2008
State/Local Invited Seminars/Lectures, Trinity College, HHMI-sponsored Undergraduate Research Program, Trinity College, Hartford, CT	04/2008
National and International Invited Seminars/Lectures, Innovation and Reform in Clinical Trial Design: Implementation of Biomarkers in Clinical Trial Design, Toronto, ON, CAN	10/2007
State/Local Invited Seminars/Lectures, Connecticut Technology Council, 2008 Women of Innovation, CT Technology Council, New Haven, CT	08/2007
State/Local Invited Seminars/Lectures, University of Maryland Medical Center, Molecular Pathology, University of Maryland Medical Center, Baltimore, MD	06/2007
National and International Invited Seminars/Lectures, Gynecologic Oncology Group, 2007 Semi-Annual Meeting, GOG, San Diego, CA	01/2007
State/Local Invited Seminars/Lectures, Roswell Park Cancer Institute, Buffalo, NY	09/2006
State/Local Invited Seminars/Lectures, Albert Einstein College of Medicine, Department of Structural Biology, NY, NY	06/2006
State/Local Invited Seminars/Lectures, Mount Sinai School of Medicine, Department of Oncological Sciences Lecture Series	05/2005
Invited Symposia, Lynn Cohen Foundation for Ovarian Research, NY, NY	04/2005
State/Local Invited Seminars/Lectures, Receptor Biologix Inc., San Francisco, CA	11/2004
State/Local Invited Seminars/Lectures, Pfizer R & D, Groton, CT	10/2004
Regional Invited Seminars/Lectures, Cancer Education Consortium, "Cancer and Growth Factor Receptors" and "Testing Cancer for HER2 Expression: Lessons Learned", Cancer Education Consortium, Virginia Beach, VA	06/2004
State/Local Invited Seminars/Lectures, Third Early Detection Research Network Scientific Workshop, Bethesda, MD	05/2004
Invited Symposia, North Dakota State University, Women's Health Symposium, North Dakota State University, Fargo, ND	03/2004
State/Local Invited Seminars/Lectures, Ventana Medical Systems, Tucson, AZ	03/2004
State/Local Invited Seminars/Lectures, University New Mexico Cancer Center, Albuquerque, NM	03/2004
National and International Invited Seminars/Lectures, AACR Meet-the-Expert Sunrise Session, "Soluble EGFR/HER Receptors: Form, Function, and Clinical Utility as Serum Biomarkers", AACR, Washington, DC	07/2003
Invited Symposia, Eppley Visiting Professor of Oncology, Symposium Chair and Lecturer, "Biology of Breast Cancer", Univ Nebraska Medical Center, Omaha, NE	05/2003
State/Local Invited Seminars/Lectures, Pfizer Global Research and Development (Oncology Division), Pfizer, Groton, CT	02/2003
National and International Invited Seminars/Lectures, "Colloquium on Protein Structure, Function, and Dynamics: Frontiers in Protein Spectroscopy" Session Chair and Speaker, Ponce, PR	02/2003
State/Local Invited Seminars/Lectures, Yale School of Medicine, Pathology Grand Rounds, Yale University, New Haven, CT	02/2003
State/Local Invited Seminars/Lectures, Van Andel Cancer Research Institute, Grand Rapids, MI	01/2003
National and International Invited Seminars/Lectures, ASCO Molecular Therapeutics Symposium, "Receptor Tyrosine Kinase Inhibitors in the Treatment of Gynecologic Malignancies" (Session Chair and Speaker), ASCO, San Diego, CA	11/2002
National and International Invited Seminars/Lectures, "Integration of Research and Treatment" 4th Ovarian Cancer Research Symposium, Seattle, WA	09/2002
State/Local Invited Seminars/Lectures, Robert H. Lurie Cancer Center of Northwestern University and Northwestern Memorial Hospital's Ovarian Cancer Early Detection Conference, Symposium Co-chair and Speaker, Northwestern University, Chicago, IL	09/2002
State/Local Invited Seminars/Lectures, Fox Chase Cancer Center, Philadelphia, PA	08/2002
State/Local Invited Seminars/Lectures, Yale University - OBGYN, New Haven, CT	06/2002
Regional Invited Seminars/Lectures, Session Chair, Molecular Mechanisms Underlying Ovarian Cancer: Implications for Prevention and Treatment, University of Pittsburgh Cancer Institute, Pittsburgh, PA	05/2002
State/Local Invited Seminars/Lectures, University Utah Medical School - Huntsman Cancer Center, Salt Lake City, UT	05/2002
Regional Invited Seminars/Lectures, Society for Gynecologic Investigation, Los Angeles, CA	03/2002
Regional Invited Seminars/Lectures, Gordon Research Conference, "New Frontiers in Cancer Detection and Diagnosis", Gordon Research Conference, Ventura Beach, CA	03/2002
State/Local Invited Seminars/Lectures, Oklahoma University Health Sciences Center, Department of Biochemistry and Molecular Biology, Norman, OK	02/2002
State/Local Invited Seminars/Lectures, University of Illinois at Chicago Medical School, Department of Pharmaceutics and Pharmacodynamics, Chicago, IL	01/2002
State/Local Invited Seminars/Lectures, University of Maryland Medical School, Baltimore, MD	12/2001
State/Local Invited Seminars/Lectures, University of Puerto Rico, Mayaguez, PR	12/2001
State/Local Invited Seminars/Lectures, University of Puerto Rico Medical School, San Juan, PR	12/2001
State/Local Invited Seminars/Lectures, Brown University Medical School, Providence, RI	07/2001
State/Local Invited Seminars/Lectures, University of California San Francisco Cancer Center, San Francisco, CA	05/2001
Regional Invited Seminars/Lectures, Bi-annual Tumor Markers Conference, Santa Barbara, CA	03/2001
State/Local Invited Seminars/Lectures, University of Texas Medical Center, Department of Molecular Medicine, San Antonio, TX	02/2001
State/Local Invited Seminars/Lectures, Cleveland Clinic Cancer Center, Cleveland, OH	12/2000
State/Local Invited Seminars/Lectures, University of Minnesota, Department of Pharmacology, Minneapolis, MN	11/2000
State/Local Invited Seminars/Lectures, University of Wisconsin Medical School, Cancer Center, Madison, WI	11/2000
State/Local Invited Seminars/Lectures, University of North Dakota, School of Medicine, Department of Biochemistry, Fargo, ND	10/2000
National and International Invited Seminars/Lectures, Session Chair, Ovarian Cancer 2000: Translational Research - Outcomes and Opportunities, Seattle, WA	09/2000
Regional Invited Seminars/Lectures, First Annual Early Detection Research Network Workshop, Chicago, IL	09/2000
National and International Invited Seminars/Lectures, NCI Workshop on Ovarian Cancer Screening, NCI, Bethesda, MD	09/2000
State/Local Invited Seminars/Lectures, Northwestern University Medical School, Department of Pharmacology, Chicago, IL	09/2000
State/Local Invited Seminars/Lectures, Washington University, Department of Obstetrics and Gynecology, St Louis, MO	08/2000
State/Local Invited Seminars/Lectures, Fred Hutchinson Cancer Center, Seattle, WA	07/2000
State/Local Invited Seminars/Lectures, University of Pittsburgh Cancer Center, Pittsburgh, PA	07/2000
National and International Invited Seminars/Lectures, AACR Mini-symposium, "EGF Receptor Family Tyrosine Kinases", AACR	04/2000
National and International Invited Seminars/Lectures, AACR Mini-symposium, "HER2 in Breast Cancer and Other Malignancies", AACR	04/2000
State/Local Invited Seminars/Lectures, Oregon Health Sciences Cancer Center, Portland, OR	04/2000
Invited Symposia, Society for Gynecologic Investigation Ovarian Cancer Symposium, Chicago, IL	03/2000
National and International Invited Seminars/Lectures, Ovarian Cancer Prevention Workshop, NCI Division of Cancer Prevention, NCI, San Francisco, CA	03/2000

Honors, Awards, and Recognition

LouAnn Woodward, M.D. Authentic Leadership Award, Group on Women in Science, University of Mississippi Medical Center	2021
Outstanding Service Award, University of Mississippi Medical Center Cancer Center and Research Institute	2020
Outstanding Faculty Member of Year, Medical College of Georgia	2016
Caught in Act Compassion Award, Medical College of Georgia	2016
Golden Pen Academic Achievement Award, Medical College of Georgia	2016
Phi Kappa Phi Honor Society, Medical College of Georgia	2015
Distinguished Alumni Award, Albert Einstein College of Medicine	2013
"Soluble Epidermal Growth Factor Receptor Isoforms and Their Uses in Cancer Detection Methods" United States Patent: 8,017,752, Inventors: J. Reiter and N. J. Maihle, USPTO	2011
"Soluble Epidermal Growth Factor Receptor Isoforms" United States Patent: 7892541, Inventors: N. J. Maihle, A. T. Baron, and J. L. Reiter, USPTO	2011
"Soluble ErbB3 Methods of Detection and Antibodies" United States Patent: 7744882, Inventors: N. J. Maihle and H. J. Lee, USPTO	2010
"Soluble ErbB3 and Treatment of Cancer" United States Patent: 7745398, Inventors: N. J. Maihle and H. J. Lee, USPTO	2010
"Soluble Epidermal Growth Factor Receptor-Like Proteins and Their Uses in Cancer Detection Methods" United States Patent: 7732157, Inventors: A. T. Baron and N. J. Maihle, USPTO	2010
"Soluble ErbB3 Method of Detection" United States Patent: 7718384, Inventors: N. J. Maihle and H. J. Lee, USPTO	2010
Innovation Pipeline Award (Most New Patents), Connecticut Technology Council	2010
"Soluble ErbB3 Receptor Isoforms" United States Patent: 7638303, Inventors: N. J. Maihle and H. J. Lee, USPTO	2009
"Soluble ErbB3 Receptor Isoforms" United States Patent: 7638302, Inventors: N. J. Maihle and H. Lee, USPTO	2009
"Methods for Inhibiting Heregulin and Treating Cancer" United States Patent: 7612042, Inventors: N. J. Maihle and H. Lee, USPTO	2009
Faculty Scholar, Harvard Macy Institute	2009
"Soluble ErbB3 Receptor Isoforms" United States Patent: 7390632 Inventors: N. J. Maihle and H. Lee, USPTO	2008
Research & Leadership Innovation Award, Connecticut Technology Council	2007
Y50K Award (2nd Place Biotechnology), Yale Univ School of Management	2007
Y2K Award (1st Place Biotechnology), Yale Univ School of Management	2007
Visiting Professor Scholarship, Pfizer Corporation	2004
Fellow, Morse Residential College, Yale University	2003
Senior Women in Medicine Professorship, Yale University	2003
Eppley Visiting Professor of Oncology, University of Nebraska Medical Center	2003
Founding Director, Tumor Biology Program, Mayo Clinic	2001
Excellence in Teaching Award, Mayo Medical School	2000
Teacher of the Year Award, Mayo Graduate School	1998
Excellence in Teaching Award, Mayo Medical School	1995
Business Advisor of the Year Award, INROADS	1993
AACR Fellowship "Histopathobiology of Neoplasia", AACR	1990
Postdoctoral Fellowship, USDA	1988
Florence B. Seibert Scholarship - Postdoctoral Fellowship, AAUW	1987
NRSA Postdoctoral Fellowship, NIH	1985
Postdoctoral Fellowship, Muscular Dystrophy Association	1984
Outstanding Young Women of America Award, Chamber of Commerce	1983
Board of Regents Scholarship, State of Ohio	1973
Member Editorial Board, Trends in Cell Biology Journal Club Board (2001-02)
Member Editorial Board, Drug Discovery (1998-2000)
Member Editorial Board, Molecular Genetics & Genomic Medicine (2019-present)

Professional Membership and Service

American Chemical Society, Board of Advisors of a Company	2020 - Present
AACR, Member, Laboratory Research Awards Committee (Clowes' Memorial and Outstanding Achievement Awards) (2013-15)
Hormel Research Institute, Member, Scientific Advisory Committee (1999-2000)
California Breast Cancer Research Program, Member, Pathogenesis Committee (2000-01)
University of Maryland School of Medicine, Chair, External Advisory Committee, Pathology Graduate Program (2001)
Ohio Cancer Research Associates, Reviewer, (2001-present)
Pacific Ovarian Cancer Research Consortium External Advisory Board (supported by NCI SPORE award; Dr. N. Urban, PI), Chair, (2001-09; Member, 2011-present)
University of Puerto Rico, Center of Biological Research Excellence (Supported by NIH COBRE award; Dr. Joseph Bonaventura, PI), Member, External Advisory Board (2001-08)
California Breast Cancer Research Program Review Panel, Chair, (2002-04)
Tumor Biology Investment Group (TBIG), Member, (2002-12)
Robert H. Lurie Cancer Center of Northwestern University (Supported by NCI CCSG; Dr. Steven Rosen, PI), Member, External Advisory Committee (2002-04)
HistoRx, Member, Scientific Advisor (2004-05)
Receptor Biologix, Inc., Member, Scientific Advisor (2004-05)
Catalyst Oncology, Member, Scientific Advisory Board (2004-07)
Van Andel Institute Graduate School, Charter Board Member, Board of Directors, (2004-07; re-appointed, 2008-11)
Bexion Pharmaceuticals, Inc, Chair, Scientific Advisory Board (2012-present)
Fox Chase Cancer Center, Ovarian Cancer Program (supported by NCI SPORE Award, Dr. R. Ozols, PI), Member, External Advisory Board (2008)
Maryland Technology Development Technology Transfer Program, Reviewer, (2008 & 2011)
Fox Chase Cancer Center, Ovarian Cancer Program (supported by NCI SPORE Award, Drs. G. Coukos and M. Seiden, Co-PIs), Chair, External Advisory Board (2009-12)
National Priorities Research Program, Qatar National Research Fund, Member, (2010 - present)
M. D. Anderson Cancer Center, Member, External Review Panel, Department of Gynecologic Oncology (2010)
Nevada Cancer Institute, Chair, External Advisory Board (COBRE)(2010-11)
Ovarian Cancer Research Fund, Member, Scientific Review Panel (2011)
Martell Diagnostics, Inc., Member, Scientific Advisory Board (2011 - present)
Loring Life Sciences, Inc., Co-founder and Board Member (2012 - present)
LifeScience Ventures, Ltd., Member, Scientific Advisory Board (2012-13)
Fondazione Cariplo, Milan, Italy, Member, Scientific Advisory Board (2012 - present)
Coalition for the Life Sciences, Member, Advocacy and Public Policy (2005-present)
American Indian Society for Science and Engineering, Member, Scholarship Review Panel (2014)
Biomedical Research Conducted by Young Investigators - Phase I & II; Fondazione Cariplo, Member, Panel Review (2014-19)
Cancer Research UK, Funding Scheme Science Committee, Multidisciplinary Project, Member, Review Panel (2015)
Qatar National Research Fund, National Priority Research Program, Member, Review Panel (2015 & 2019)
Marsha Rivkin, Member, Scientific Reviewer, Rivkin Center for Ovarian Cancer Research Grants Program (2016-19)
NIH, Member, NIH-sponsored NRMN Group Mentor (National Research Mentoring Network) - Grant Writing Coach - U.S. Southeast Region (2016-present)
2017 Annual World Congress on Biomarkers & Clinical Research, Member, Organizing Committee
University of Pittsburgh Medical Center, Member, Ovarian Cancer and High-Risk Women (University of Pittsburgh Medical Center) (2001-02)
Marsha Rivkin, Member, Biennial Marsha Rivkin Center Ovarian Cancer Research Symposia (Seattle, WA) (2003-13)
University of Pittsburgh Medical Center, Member, Ovarian Cancer and High-Risk Women (University of Pittsburgh Medical Center) (2003-2004)
Marsha Rivkin, Member, Think Tank Steering Committee, Marsha Rivkin Center for Ovarian Cancer Research (2008-09)
CABTRAC, Member, (Cancer Biology Training Consortium) 11th Annual Meeting Planning Committee, Pittsburgh, PA (2016)
VA, Reviewer, Merit Review Board for Oncology (1990)
NIH, Member, "Cell Biology and Physiology" Study Section (1991)
VA, Member, "Career Development Program" Review Panel (1991)
NSF, Member, (EPSCoR Program) Review Panel (1992)
NIH, Member, GCRC Site Visit Team (Cedars-Sinai Medical Center) (1993)
NIH, Member, "Cell Biology & Physiology" Study Section (Subcommittee 2) (1993-97)
NCI, Member, Program Project Site Visit Team (UCLA Medical School) (1994)
NIH, Member, GCRC Site Visit Team (University of Texas Medical Center) (1994)
NCI, Member, Cancer Center Site Visit Team (Vanderbilt University Cancer Center) (1995)
NCI, Member, Task Force on Intergroup Tumor Banks (1995)
NCI, Member, Cancer Center Support Grant Review Committee (1995)
NCI, Member, Program Project Site Visit Team (SUNY Stony Brook) (1995)
NCI, Member, Cancer Center Site Visit Team (Norris Cancer Center, Los Angeles, CA) (1995)
NCI, Member, Cancer Center Support Grant Review Committee (1995)
NCI, Member, Cancer Center Support Grant Review Committee (1996)
FDA, Member, Site Visit Team (Laboratory of Cell Biology, Division of Cytokine Biology) (1996)
NCI, Member, Cancer Center Site Visit Team (Univ. of Iowa) (1996)
NCI, Member, Program Project Site Visit Team (M.D. Anderson Cancer Center) (1997)
NCI, Member, Cancer Center Site Visit Team (Kaplan Cancer Center, NY) (1998)
NCI, Member, NCI and Society of Gynecologic Oncologists "Ovarian Cancer Strategic Plan and Implementation" Task Force, Bethesda, MD (1998)
NCI, Member, Cancer Center Site Visit Team (Univ. of Virginia Medical School, Charlottesville, VA) (1999)
NCI, Member, Program Project Site Visit Team (Univ. California, San Francisco) (1999)
NIH, Member, Experimental Therapeutics-1 Study Section (1999)
NCI, Member, Ovarian Cancer SPORE Review Panel (1999)
NCI, Member, Cancer Center Site Visit Team (Moffitt Cancer Center, Tampa, FL) (1997, 2000)
NCI, Member, Mouse Models of Human Cancers Consortium: Ovarian Cancer "Think Tank" (San Francisco, CA) (1997-2000)
NCI, Member, Scholars Program Scientific Review Panel (1999-2001)
NIH, Member, Experimental Therapeutics-1 Study Section (2000)
NCI, Member, Cancer Center Site Visit Team (Albert Einstein College Medicine) (1996, 2001)
NCI, Member, Gynecologic Malignancies PRG Panel (2001)
NIH, Member, Center for Scientific Review Study Section Boundaries - Oncological Sciences (2001)
NCI, Member, Breast Cancer SPORE Review Panel (2002)
NCI, Member, Cancer Center Site Visit Team (Irving Cancer Center, Columbia Univ., NY) (2003)
NIH, Chair, Bioengineering Research Partnership Review Panel (SBIR) (2003)
NCI, Board Member, Board of Scientific Counselors (2007-12)
NCI, Member, Cancer Center Site Visit Team (University of Miami Cancer Center, FL) (2008)
NCI, Member, SBIR Technical Emphasis Panel (TEP)-Molecular Diagnostics (2009)
NCI, Chair, Centers of Cancer Nanotechnology Excellence Review Panel (2010)
NCI, Chair, Extramural Review Panel, NCI CCR Laboratory of Mammary Gland Biology (2011)
NCI, Chair, SBIR TEP - Quantitative Tissue Imaging for Clinical Diagnosis and Treatment (2011)
NCI, Chair, Extramural Review Panel, NCI CCR Laboratory of Cell and Cancer Biology (2012)
NCI, Chair, Extramural Review Panel, NCI R21’s (Molecular Diagnostics) (2012)
NCI, Co-chair, NCI Omnibus Review Panel (2012)
NCI, Member, Site Visit Team, Early Detection Research Network, Clinical Validation Center, Fox Chase Cancer Center, Philadelphia, PA (2013)
NCI, Member, Site Visit Team, Early Detection Research Network, Biomarker Development Laboratory, Mass General Hospital, Boston, MA (2013)
NCI, Member, Site Visit Team, Early Detection Research Network, Biomarker Discovery Laboratory, Fred Hutchinson Cancer Center, Seattle, WA (2013)
NCI, Member, Review Panel, Nanotechnology Based Theranostics (U43/44) (2013)
NCI, Member, Executive Steering Committee, NCI-funded (U24) TIES Cancer Research Network (TCRN; 2013-present)
NCI, Member, NCI Review Panel, Provocative Questions (2014)
NCI, Member, NCI Oncology I - IRG (Pre- and Postdoctoral Fellowships Scientific Review Panel) (2015)
NCI, Chair, Review Panel for 'Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE/U54)' (2015)
NCI, Chair, Review Panel for 'Feasibility Studies to Build Collaborative Partnerships in Cancer Research (P20)' (2015)
NCI, Co-chair, Review Panel for Oncology 1 Basic Translational Review in Cancer Research (F09)(2017)
NCI, Chair, Review Panel for Clinical and Translational Exploratory/Developmental Studies (R21) (2018)
NCI, Chair, Review Panel for Small Grants Program for Cancer Research (NCI Omnibus R03) (2018)
USAMRDC Prostate Cancer Research Program, Member, Scientific Review Panel (1998)
USAMRDC Ovarian Cancer Research Program, Member, Scientific Review Panel (1999
USAMRDC Ovarian Cancer Research Program, Chair, Scientific Review Panel (2000-01)
USAMRDC Ovarian Cancer Research Program, Member, Integration Panel (2003-08)
USAMRDC Ovarian Cancer Research Program, Chair, Integration Panel (2006-08)
USAMRDC Ovarian Cancer Research Program, Chair, Scientific Review Panel (2009)
USAMRDC Ovarian Cancer Research Program, Chair, Scientific Review Panel (2011)
USAMRDC Ovarian Cancer Research Program, Co-chair, Award Review Panel (2012)
USAMRDC Ovarian Cancer Research Program, Member, (Ad Hoc), Integration Panel (2013)
USAMRDC Ovarian Cancer Research Program, Member, Award Review Panel (2013)
USAMRDC Ovarian Cancer Research Program, Chair, Scientific Review Panel (2014)
USAMRDC Ovarian Cancer Research Program, Chair, Scientific Review Panel (2015)
USAMRDC Ovarian Cancer Research Program, Chair, Scientific Review Panel (2017)
USAMRDC Ovarian Cancer Research Program, Chair, Scientific Review Panel (2019)
USAMRDC Breast Cancer Research Program, Member, Scientific Review Panel (1997)
USAMRDC Breast Cancer Research Program, Chair, Scientific Review Panel (2000-02)
USAMRDC Breast Cancer Research Program, Chair, Scientific Review Panel (2011)
USAMRDC Breast Cancer Research Program, Chair, Scientific Review Panel (2012)
USAMRDC Breast Cancer Research Program, Co-chair, Award Review Panel (2012)
USAMRDC Breast Cancer Research Program, Chair, Scientific Review Panel (2015)
USAMRDC Breast Cancer Research Program, Member, Scientific Review Panel (05/2019)
USAMRDC Breast Cancer Research Program, Chair, Scientific Genetics Review Panel (2016)
USAMRDC Breast Cancer Research Program, Chair, Scientific Review Panel (01/2017)
USAMRDC Breast Cancer Research Program, Chair, Scientific Review Panel (08/2017)
SGI, Member, Nominations Committee (2004-05)
SGI, Member, Membership Committee (2003-04)
Connecticut Technology Council's Women of Innovation (10th Anniversary Meeting), Member, Nominating Committee (2013-14)
North Central Cancer Treatment Group (NCCTG), Member, Laboratory Correlative Science Committee (1993-98)
North Central Cancer Treatment Group (NCCTG), Member, Executive Committee (1994-98)
National Ovarian Cancer Early Detection Research Network, Founding Co-director, (Dr. David Fishman, Director; Northwestern University) (2003-05)
National Ovarian Cancer Coalition Medical Advisory Board, Member, (2003-07)
GOG, Member, GOG/NCI-Sponsored Gynecologic Cancers Translational Research Retreat (Planning Committee) (2000)
GOG, Chair, Task Force on Industry Relationships (2011-12)
GOG, Member, Member, Committee on Experimental Medicine (Developmental Therapeutics Subcommittee) (2000-present)
AACR, Member, Program Committee, Women in Cancer Research (2001)
AACR, Chair, Charlotte Friend Memorial Award Selection Committee (2002-03)
AACR, Member and Round Table Discussion Leader, Grant Writing Workshop (2002-05
AACR, Member, Education Committee (2003-05)
AACR, Member, Kirk A. Landon Prize Nominating Committee (2004-05)
AACR, Facilitator, Cancer Research Professional Advancement Workshop (2005)
AACR, Moderator, WICR Professional Leadership Development Workshop (2005)
AACR, Chair, Women in Cancer Research, Nominating Committee (2005-06)
AACR, Chair, Women in Cancer Research (2005-06)
AACR, Chair, Charlotte Friend Memorial Award Selection Committee (2006)
AACR, Co-chair, Grant Writing Workshop (with Dr. William Beck) (2006)
AACR, Member, Executive Committee, Women in Cancer Research (2005-07)
AACR, Member, Education Committee (2008-10)

Committee Service

SCHOOL OF MEDICINE-FACULTY APPOINTMENTS, PROMOTIONS AND TENURE, Member	2021 - Present
Biospecimens Access Committee (BIOBANK), Member	2019 - Present
SCHOOL OF MEDICINE-ADMISSIONS INTERVIEW, Member	2019 - Present
Research Cores Advisory Board, Member	2019 - Present
Legislative Alert Committee, American Society for Cell Biology (1990-92), Member
Academic Appointments and Promotions Committee, Department of Biochemistry and Molecular Biology, Mayo Clinic (1989-94), Member
Mayo Medical School, M.D.-Ph.D. Admissions Committee (1989-93), Member
Mayo Graduate School Curriculum Steering Committee (1989-90), Member
Mayo Foundation Equal Opportunities Committee (1989-91), Member
Mayo Foundation Equal Opportunities Committee (1990-91), Vice Chair
Mayo Medical School Faculty Development Committee (1990-91), Member
Mayo Search Committee, Department of Biochemistry, Mayo Clinic (1990-91), Member
Mayo Search Committee, Cancer Biology, Mayo Clinic (1990-91), Member
Mayo Research Committee Task Force, "Celebration for Research" (1990-91), Member
Mayo Molecular Neurosciences Education Committee (1990-93), Member
Pruitt Society Subcommittee (Mayo Foundation Faculty Development) (1991-92), Chair
Mayo Foundation Medical/Industry Relations Committee (1991-95), Member
Mayo Medical School 2nd Year Curriculum Task Force (1991-92), Member
Mayo Task Force on "PCR Technology and Intellectual Property," Mayo Foundation (1991-92), Member
Mayo Basic Science Lectures for "Medical Grand Rounds" (1991-98), Coordinator
Mayo Graduate School Task Force on "Core Curriculum" (1991-92), Member
Task Force on "Minority Summer Student Programs," Mayo Foundation (1991-1992), Chair
Mayo Cancer Center Director's Advisory Committee (1990-97), Member
Mayo Executive Subcommittee of Medical/Industry Relations Committee (1992-95), Member
Personnel Subcommittee of Mayo Research Committee, Mayo Foundation (1992-94), Member
Mayo Minority Student Summer Program, Mayo Graduate School (1992-93), Chair
Congressional Liaison Committee of the Joint Steering Committee for Public Policy, American Society for Cell Biology (1992-95), District Coordinator
Mayo Women's Cancer Program, Mayo Cancer Center (1992-98), Founding Co-director
Mayo Foundation Medical/Industry Relations Committee (1993-95), Vice Chair
Mayo Graduate School Education Committee, (1993-95), Member
Mayo Tumor Biology Education Committee (1993-2003), Chair
Mayo Breast Cancer Research Committee (1993-98), Co-Chair
Mayo Radiation Safety/IACUC Task Force, Research Committee (1993), Chair
Mayo Search Committee, Radiation Biology/Oncology (1994-96), Member
Mayo Conflict of Interest Task Force, Mayo Foundation (1994-95), Chair
Congressional Liaison Committee of the Joint Steering Committee for Public Policy, American Society for Cell Biology (1995-2003), Regional Coordinator
Mayo Tumor Biology Training Program, Mayo Clinic (1992-2003), Founding Director
Mayo Cancer Center Clinical Research Committee, Mayo Clinic (1995-97), Member
Mayo Scientific Advisory Board, "Studies of Monoclonal Gammopathies," (NCI-sponsored Program Project, Dr. Robert Kyle, PI; 1995-2003), Chair
Mayo Medical Laboratories Faculty Search Committee (1996-97), Member
Mayo Waiver of Patent Rights Subcommittee (Medical/Industry Relations Committee), Mayo Foundation (1995), Chair
Mayo Scientific Advisory Board, "Glioblastoma/Brain Tumors," (Supported by NCI SPORE award; Dr. Brian O'Neill, PI; Mayo Clinic; 1995-2013), Member
Mayo Search Committee, Oncology Nursing Research (1995), Member
Mayo Search Committee, Staff Scientist, Mayo Clinic Cancer Center (1995-96), Chair
Mayo Search Committee, Molecular Epidemiologist, Health Sciences Research (1997), Member
Mayo Steering Committee, Neuro-Oncology Training Program (1999-2003), Member
Mayo Scientific Advisory Board, "Prostate Cancer Program," (Supported by NCI SPORE award; Dr. Donald J. Tindall, PI; Mayo Clinic; 2000-03), Member
Yale Clinical Investigation Task Force, School of Medicine (2004-2005), Member
Yale Biotechnology and Biopharmaceutical Society (2004-08), Faculty Advisor
Yale Academic Promotions Committee, Department of Obstetrics, Gynecology & Reproductive Sciences (2004-13), Member
Yale Special Committee for the Dean's Office, School of Medicine (2006), Member
Yale Funds and Fellowship Committee, School of Medicine (2005-2008), Member
Yale Center for Clinical Investigation (NIH CTSA-sponsored) Translational Pilot Awards Review Panel (2010), Member
Yale Grantsmanship Workshop Co-Organizer, 'NIH Funding - How to Get It, How to Keep It,' Office of Sponsored Programs (2010-11), Co-organizer
Yale Academic Promotions Committee, Department of Epidemiology, Yale School of Public Health (2010-11), Member
Yale Women's Faculty Forum (2010-13), Member
Yale Provost's Interdepartmental Mentoring Program (2011-13), Member
Yale External Faculty Advisor, (2013-2018), Member
Yale Faculty Advisory Council, Career Network for Science Ph.D.'s at Yale (CNSPY; 2012-2013), Member
Search Committee, Chair position - Biochemistry and Molecular Biology, Medical College of Georgia (2014 - 2015), Co-Chair
Faculty Recruitment Committee, Georgia Cancer Center (2013 - 2018), Member
Steering Committee, Georgia Cancer Center (2013 - 2018, Member
Executive Committee, Georgia Cancer Center (2013 - 2018), Member
Steering Committee, Georgia Cancer Center Integrative Oncology Program (2013 - 2018), Member
Augusta University Provost's 'Vision 2030' Task Force (2013 - 2014), Member
Augusta University Center for Undergraduate Research & Scholarship Steering Committee (2014 - 2018), Member
Augusta University Faculty Development Coordinating Council (2014 - 2018), Member
Augusta University Provost's Academic Mission Strategic Planning Focus Group (2014), Member
Augusta University Biospecimen Tissue Use and Procurement Review Committee (2015 - 2018), Member
Augusta University Cancer Center Promotion and Tenure Appointments Committee (2015 - 2018), Member
Augusta University Teaching Effectiveness Task Force (2015), Member
Augusta University Faculty Development Subcommittee, University Faculty Senate (2015), Vice Chair
American Cancer Society Institutional Research Grant Review Panel (2015 - 2018), Co-Chair
Augusta University Program Review Panel, Clinical Translational Science Program (2015 - 2018), Member
Augusta University Faculty Mentorship Board, 'Arsenal' - An AU Undergraduate Research Journal (2015 - 2018), Member
Augusta University Executive Committee, MCG Faculty Senate (2015 - 2018), Member
Augusta University Georgia Eminent Faculty Scholar Search Committee (2015 - 2018), Member
Augusta University Office of Leadership Development Faculty Council (2015 - 2018), Member
Augusta University Biochemistry and Cancer Biology Training Program Steering Committee (2016 - 2018), Member
Augusta University Georgia Regents Award Nomination Committee (2016 - 2018), Member
Augusta University Provost's Research Strategic Focus Planning Committee (2016 - 2018), Member
Augusta University Faculty Development Subcommittee, University Faculty Senate (2016 - 2017; member, 2016 - 2018), Chair
Augusta University Office of Faculty Development Awards Committee (2016 - 2017), Member
Augusta University Internal Advisory Board, Institute of Prevention and Public Health (2017 - 2018), Member
Augusta University Bioethics Committee (2017 - 2018), Member
Augusta University Search Committee, Institute of Prevention and Public Health (2017 - 2018), Member
Augusta University Research Institute Board (2017 - 2018), Board Member

Community Service

Hope Lodge - fundraiser, Member Org Committee	02/2006 - 12/2006
Ronald McDonald House - fundraiser, Chair	03/2005 - 10/2005
National Ovarian Cancer Coalition Medical Advisory Board, Member	2003 - 12/2006
Girl Scouts of USA, Volunteer	06/2000 - 05/2001
Girl Scouts of USA, Troop Leader	06/1999 - 05/2000

Teaching Experience

CMB 744, Graduate, Course, Lecturer, Cellular Biochemistry

Spring 2021 - 2021

Directed Student Learning

Research Advisor, Advised: Lindsay Turner	2021 - Present
Research Advisor, Advised: Martin McCandless	2020 - Present
Research Advisor, Advised: Maris Hardee	2020 - Present
Preceptor, TBD Advised: Melissa Robinson	2019 - 2012
Undergraduate Honors Thesis, Advised: Tim Malik, Elsie Sowah, Songmin Song, Sejal Hathi, Ka Ian Lio, Peter Shindler, Kristy Webster, Erin Mulvihill, Nneoma Nwachuka, Lindsey Greene, Maureen Braun, Jessica Colon, Giselle Roman, Holli Heffner, Brandi Freeman, Amel Dudakovic, Megan Kasperbauer, Erin Mulvihill, Angela Wheeler-McCleary, Liz Ping Ng, Julie Havlovic, Adam Sakhitab, Emily Brandl-Salutz, Ellen Anderson, Evan Brutinel, Corrie Klopcic, Courtney Lovejoy, Jaime Darce, Lisa Lenertz, Emily Ward, Erin Wes Swingley, Amil Gatza, Elena Frank, Katherine Iossi, Gaurav Khanna, Elis Suichies, Carl Sherman, Thomas Ehrich, Laura Sikkink, Richard Ashley, Andrea Lampland, Debra Teo, Paul Thomas, Elizabeth Coons, Maureen Alt, Tonia Crossley, Shari Meeker, Wendy Lipworth, Jennifer Peoples, Irette Patterson, Tracey Martin, Kathryn Johnson, Judy Heddens, Ravi Kanagala
Master's Thesis Committee Chair, Advised: Kindrea Myles, Tayf Badri, Jacqueline Lafky, Andrew Danielsen, Ayfel Kerimo, William Sullivan, Dane Mathiesen, Karen Showalter
Research Advisor, Advised: Ryan Goetz, Blake Vander Wood, Mojun Zhu, Aletta Houwink, Marianela Perez, Jessica Faupel-Badger, Jonathan Hoyne, Julie Boerner, Margaret Adelsman, Inder Sehgal, Ruben Mesa

Fellows supervised

Cancer Research - UMMC, Research Advisor, 45 fellows supervised	07/2019 - 06/2022
Cancer Research, Post-Doc Advisor, 0 fellows supervised, Maihle Lab

Extramural, The Ovarian Cancer Academy 2020-2025, Dept of Defense	09/2020 - 09/2025
Extramural, Healthy Aging Initiative, Joe W. and Dorothy Dorsett Brown Foundation	01/2020 - 12/2020
Extramural, Colleen's Dream Ovarian Cancer Research Award, Colleen's Dream Ovarian Cancer Research Foundation	01/2020 - 12/2020
Extramural, NIH/NSF ASCB Minority Affairs Committee Faculty Research and Education Development Program Mentor Award, NIH/NSF	07/2018 - 06/2019
Extramural, NIH/NSF ASCB Minority Affairs Committee Faculty Research and Education Development Program Mentor Award, NIH	07/2017 - 06/2018
Extramural, NIH/NSF ASCB Minority Affairs Committee Faculty Research and Education Development Program Mentor Award, NIH	07/2016 - 06/2017
Extramural, The Ovarian Cancer Academy 2020-2015: A Data-Driven Learning, Department of Defense	10/2015 - 09/2020
Extramural, National Institute of Child Health and Development 'Women's Reproductive Health Research', NICH	07/2015 - 06/2020
Extramural, National Science Foundation ASCB Minority Affairs Committee Faculty Research and Education Development Program Mentor Award, NSF	07/2015 - 06/2016
Extramural, USAMRDC Ovarian Cancer Research Program 'Ovarian Cancer Academy Dean' Award, USAMRDC	07/2015 - 06/2020
Intramural, Combining Models to Overcome Trastuzumab Resistance in Breast Cancer, Augusta Univ Cancer Center Basic Science Award	10/2014 - 10/2015
Extramural, National Institute of Heart, Lung, and Blood 'Program to Increase Diversity among Individuals Engaged in Health-related Research', NICH	10/2014 - 09/2018
Extramural, National Cancer Institute 'TIES Translational Research Network Consortium', NCI	09/2013 - 08/2018
Extramural, Development of Serum sEGFR as a New Biomarker in a Mouse Model of Lung CA, Labrecque Foundation for Lung Cancer Research	03/2012 - 02/2014
Extramural, "A Preclinical Study of p45-sHER3: A Metastasis Factor in Melanoma", Harry J. Lloyd Charitable Foundation	12/2011 - 11/2014
Intramural, Murine sEGFR: a New Biomarker in Lung Cancer, Yale Cancer Center	06/2011 - 08/2011
Extramural, Susan G. Komen for the Cure Foundation Award, Komen	01/2011 - 12/2016
Extramural, Serum sEGFR in Patients Treated with Lapatinib: A Search for Prognostic Factors, GOG	04/2010 - 03/2011
Extramural, Glioma Therapeutics Glioma Pathogenesis-related Protein, NIH SBIR [R43]	01/2009 - 12/2010
Extramural, Novel Mechanisms of EGFR Gene Expression Regulation, NIH NIGMS [SC2]	08/2008 - 09/2011
Intramural, A Novel Breast Cancer Biomarker, Yale Cancer Center - Swebilius Fund	07/2008 - 06/2009
Extramural, Overcoming Herceptin Resistance in Ovarian Cancer, Marsha Rivkin Center for Ovarian Cancer Research	07/2008 - 06/2010
Extramural, sErbB3: A Novel Ovarian Cancer Prognostic Marker, Marsha Rivkin Center for Ovarian Cancer Research	07/2008 - 06/2010
Extramural, Overcoming Herceptin Resistance in Ovarian Cancer, Komen	07/2008 - 10/2011
Extramural, Inhibitory Potential of sErbB3, Pardee Foundation	05/2006 - 04/2007
Extramural, Overcoming Herceptin Resistance, Ovarian Cancer Research Fund	01/2006 - 12/2006
Extramural, Overcoming Resistance to Herceptin, The Ladies Auxiliary Veterans of Foreign Wars	06/2005 - 05/2006
Extramural, Pharmacogenomics of EGFR/HER Receptor Expression in Cancer, Pfizer Visiting Professorship Program	12/2003 - 10/2004
Extramural, Sensitivity and Specificity of an sEGFR ALISA in the Detection of Ovarian Cancer, Marsha Rivkin Center Pilot Study Award	01/2003 - 12/2003
Extramural, EGF Receptor Blockade in Endometrial Cancer, National Cancer Institute [R01]	07/2002 - 06/2007
Extramural, p60 sErbB1: A Negative Regulator of EGF-Stimulated Breast Carcinoma Cell Growth, U. S. Army Medical Research Command Predoctoral Fellowship Award	09/2000 - 08/2003
Extramural, National Ovarian Cancer Early Detection Network, NIH/NCI [U01]	04/2000 - 03/2005
Extramural, Development of an Assay for Serum sErbB1 p60: Pilot Studies in Breast Cancer Patients, Prospect Creek Foundation	01/2000 - 12/2001
Extramural, Development of an sErbB ALISA: Pilot Studies in Breast Cancer Patients, Komen	01/2000 - 12/2001
Intramural, Circulating sErbB1, sErbB2, and CA-125 Levels as Diagnostic and Prognostic Biomarkers in Women with Epithelial Ovarian Cancer, Mayo Foundation Clinician Investigator Award	06/1999 - 05/2000
Extramural, Serologic sErbB1 in Healthy Women, NIH/NCI [R03]	06/1999 - 05/2001
Extramural, Serologic sErbB2 Levels as Diagnostic Tumor Biomarkers, NIH/NCI [R21]	06/1999 - 05/2001
Extramural, Circulating sErbB1/2 Levels as Breast Cancer Biomarkers, Friends You Can Count On Foundation	01/1999 - 12/2000
Extramural, sErbB1 and sErbB2 Receptor Expression Patterns in Women with Breast Diseases, Prospect Creek Foundation	01/1999 - 12/2000
Extramural, Randomized Phase II Trial of Irinotecan (CPT-II) in Patients with Refractory Metastatic Breast Cancer, Pharmacia and Upjohn	10/1998 - 12/1999
Extramural, Randomized Phase II Trial of Paclitaxel, Carboplatin and rhuMAbHER-2 (Herceptin) as First-line Chemotherapy in Patients with Metastatic Breast Cancer Who Overexpress HER-2, Genentech	10/1998 - 09/2000
Extramural, EREs in the Amphiregulin Gene, NIH/NCI [K01]	08/1998 - 07/2002
Extramural, Biology of Cancer: A Predoctoral Training Program, NIH/NCI [T32]	07/1998 - 06/2003
Extramural, Soluble ErbB1 Molecules as Tumor Biomarkers, NIH/NCI [K07]	07/1998 - 06/2003
Extramural, Mechanisms of Ligand-independent EGFR Signaling in Human Glioblastomas, Fraternal Order of Eagles Cancer Research Fund	04/1998 - 09/1999
Extramural, Modulation of Heregulin Mediated Breast Carcinoma Cell Growth by Soluble ErbB3, NIH/NCI [R21]	10/1997 - 09/1998
Extramural, Randomized Phase II Study of Docetaxel and Doxorubicin/ Cyclophosphamide (AC) in Patients with Metastatic Breast Cancer, Rhone-Poulenc Rorer Fund	10/1997 - 12/1998
Extramural, Development of a New Model to Study the Interactions of Obesity on the Development of Breast Cancer, U. S. Army Medical Research Command	09/1997 - 08/2000
Extramural, Differential Expression of Alternative Transcripts from the Human Epidermal Growth Factor Receptor Gene in Normal and Malignant Ovarian Tissues, Fraternal Order of Eagles Cancer Research Fund	05/1997 - 04/1998
Extramural, sErbB1 and sErbB2 Receptor Expression Patterns in Women with Breast Diseases, Prospect Creek Foundation	01/1997 - 12/2000
Extramural, IL-6 and sIL-6 Growth Inhibition of Breast Cancer Cells, NIH [R01]	04/1996 - 03/2000
Extramural, IL-6 and sIL-6R Growth Inhibition of Breast Carcinoma Cells, Komen	01/1996 - 12/1997
Extramural, Amphiregulin in Prostate Cancer, Pardee Foundation	01/1996 - 12/1997
Extramural, Mechanisms of Human sErbB1 Inhibition of Transformation, NIH [NRSA]	07/1995 - 07/1997
Extramural, Development of a Breast Cancer Research Program at Mayo, NIH/NCI [P20]	12/1994 - 11/1998
Extramural, Biology of Breast Cancer: A Predoctoral Training Program, U. S. Army Medical Research Command	09/1994 - 08/1998
Extramural, Tamoxifen Effects on Interleukin-6 Pathways in Human Breast Cancer, NIH/NCI [U10 Supplement]	06/1994 - 05/1995
Extramural, Interleukin 6 Growth Inhibition of Breast Carcinoma Cells, Fraternal Order of Eagles' Cancer Research Fund	05/1994 - 04/1995
Extramural, Associate Director for Basic Sciences/Cancer Research, NIH/NCI-Sponsored Mayo Cancer Center [P30 - CCSG]	01/1994 - 12/1998
Extramural, Truncated c erbB Receptors in Ovarian Carcinomas, NIH/NCI [NRSA]	01/1993 - 12/1993
Extramural, Tissue specific Tumorigenesis by the c erbB Oncogene, NIH/NCI [K11]	09/1992 - 08/1997
Extramural, Mechanisms of Ligand-Independent Transformation by c erbB, NIH/NCI [K11]	09/1992 - 08/1994
Extramural, Truncated c erbB Receptors in Women with Ovarian Cancer, NIH [R01]	08/1992 - 07/1997
Extramural, Growth Factors and Cancer Program, NIH/NCI-Sponsored Mayo Cancer Center [P30 - CCSG]	03/1992 - 02/1997
Extramural, Characterization of a Novel c-erbB Related Transcript, Fraternal Order of Eagles' Cancer Research Fund	05/1991 - 04/1992
Extramural, Tissue-Specific Oncogenesis Mediated by c-ErbB, NIH/NCI [R01]	12/1989 - 12/1994

Nita J. Maihle

Biography

Education

Current Positions

Academic Appointments or Other Previous Appointments

Sponsored Program Funding

Publications

Letter

News

Journal Article

Abstracts

Book Chapter

Clinical Trial

Comment

Editorial