Robert E. Lewis

Robert E. Lewis

PROFESSOR EMERITUS

Department:
SOM-Pathology

Email:
rlewis@umc.edu

Education

University of Mississippi Medical Center, PhD1976
University of Mississippi at Oxford MS, PhD, Microbiology1974
University of Mississippi at Oxford, BA1969
Barnes Hospital, St. Louis, M, Histocompatibility testing including HLA and DR typing procedures.

Current Positions

Professor, School of Medicine, Department of Pathology07/1991 - Present
Director of Clinical Immunology, School of Medicine07/1984 - Present
Director of Tissue Typing Laboratory, School of Medicine07/1984 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Associate Director of Paternity Testing, UMC, School of Medicine12/1981 - 12/1993
Associate Professor, UMC, School of Medicine07/1984 - 06/1991
Assistant Professor, UMC, School of Medicine1981 - 06/1985
Assistant Professor, UMC, School of Medicine, Department of Anesthesiology07/1977 - 1985
Associate Director of Tissue Typing Laboratory, UMC, School of Medicine07/1980 - 07/1984
Associate Director of Clinical ImmunoPathology Laboratory, UMC, School of Medicine07/1981 - 06/1984
Assistant Professor, UMC, School of Medicine, Department of Pathology07/1977 - 06/1984
Instructor, University of Mississippi Medical Center, School of Medicine, Department of Pathology1976 - 1977
Instructor, University of Mississippi Medical Center, School of Medicine, Department of Anesthesiology06/1976 - 07/1977

Publications

Journal Article

Cruse, J.M., Lewis, R.E. Pierce, S., Lam, J and Tadros, Y. Aberrant expression of CD7, CD56, and CD79a antigens in acute myeloid leukemias Experimental and Molecular Pathology. 79:39-41. 2005.
Lewis, R.E., Cruse, J.M., Saunders, CM, Webb, RN and Suggs, JL Aberrant Expression of T-cell Markers In Acute Myeloid Leukemia. Experimental and Molecular Pathology. 83(3):462-263. 2007.
Suggs, JL, JM Cruse and R.E.Lewis Aberrant Myeloid Marker Expression In Precursor B-cell and T-cell Leukemias. Experimental and Molecular Pathology. 83(3):471-473. 2007.
Cruse, J.M., Lewis, R.E., Bishop, G.R.,Lampton, J.A., Mallory, M.D., Bryant, M.L. and Keith, J.C. Adhesion Molecules and Wound Healing in Spinal Cord Injury. Pathobiology, 64:193-197, 1996.
Lewis, R.E., Jr Anaerobes Isolated from Saint Louis Bay, Mississippi Master of Science Thesis, The University of Mississippi.
Lewis, R.E., M.N.Brackin, J.M.Cruse, B.T.Brackin, D.Butkus, S.Raju, M.Crawford, R.Krueger, K.Kirchner and J.Bower Anti-class II antibody production prolongs renal allograft survival. Pathology & Immunopathology Res 8:287-99, 1989.
Cruse, J.M., Lewis, R.E., Webb, R.N., Sanders, C.M. Tillman, B.F. Beason, K.L., Lam, J. and Koehler, J. Antigenic Transformantion in Plasma Cell Dyscrasia. Experimental and Molecular Pathology. 81(2):157-161. 2006.
Roe, D.L., Lewis, R.E. and Cruse, J.M Association of HLA-DQ and –DR Alleles with Protection from or Infection with HIV-1. Experimental & Molecular Pathology, 68:21-28. 2000.
Feye, G.L., G.P. Hemstreet, C. Klingensmith, J.M. Cruse, and R.E.Lewis,. Jr. Auto-antibody to kidney tubular cells during retrograde chronic pyelonephritis in rats, Nephron, 39:37l-376, l985
Cruse, J.M., Lewis, R.E., Dilioglou, S. Basic Immunology Review and Dysfunction in Spinal Cord Injury. EOS Journal of Immunology and Immunopharmacology. 21: 29-58. 2001.
Cruse, J.M., Wang, H., Lewis, R.E., Cespedes, J., Morrison, R.S., Lineaweaver, W.C., and Dilioglou, S Cellular and Molecular alterations in spinal cord Injury Patients with Pressure Ulcers: A Preliminary Report Experimental and Molecular Pathology. 72:124-131. 2002.
Lewis, R.E., Cruse, J.M., Webb, R.N., Sanders, C.M. Beason, K.L. Contrasting Antigenic Maturation Patterns in M0-M2 versus M3 Acute Myeloid Leukemias Experimental and Molecular Pathology. 83(2):269-273. 2007.
Cruse, J.M., M.N.Brackin, B.T.Brackin and R.E.Lewis Contrasting quantitative alterations in CD4+ and CD8+ lymphocytes in African Americans compared with the Caucasian population. Pathology and Immunopathology Research 8:300-313, 1989
Dilioglou, S., Cruse, J. and Lewis, R.E. Costimulatory function of umbilical cord blood CD14+ and CD34+ derived dendritic cells. Experimental and Molecular Pathology. 75: 18-33. 2003.
Lewis, R.E., Jr., W.W. Johnson, and J.M. Cruse Current views on the diagnosis of lymphomas by surface and cytoplasmic markers Survey of Immunologic Research, l:l62-l72, l982.
Cruse, J.M., Lewis, R.E., Bishop, G.R., Kliesch, W.F., Gaitan, E. and Britt, R Decreased Immune Reactivity and Neuroendocrine Alterations Related to Chronic Stress In Spinal Cord Injury and Stroke Patients. Pathobiology, 61:183-192, 1993.
Morrison III, R.S., Cruse, J.M., Wang, H. and Lewis, R.E Dendritic Cell Differentiation and Proliferation; Enhancement by Tumor Necrosis Factor-alpha Experimental and Molecular Pathology. 75:228-237. 2003.
Webb, RN, Cruse, JM, Lewis, RE Differential Cytokine and Toll-like Receptor Expression In Leukemia Experimental and Molecular Pathology. 83(3):464-470. 2007
Cruse, J.M., Lewis, R.E., Sanders, C.M., Webb, R.N., Beason, K.L., Lam, J. and Koehler J. Diminished CD10, CD13 and CD15 Expression in a Differentiated Granulocyte Population in CML. Experimental and Molecular Pathology. 83(2):274-276. 2007.
Lewis, R.E., Jr. and Cruse, J.M. Effect of anesthesia and operation on the classical pathway of complement activation. Clinical Immunology and Immunopathology, 23:666-67l, l982.
Lewis, R.E., Jr Effects of aging on immunological functions of murine macrophages. Doctor of Philosophy Dissertation, The University of Mississippi Medical Center.
Cruse, J.M., Lewis, R.E. and Dilioglou, S Effects of tumor-enhancing IgG2 on macrophage function Experimental and Molecular Pathology. 77:43-48. 2004
Cruse, J.M., Lewis, R.E., Roe, D.L., Dilioglou, S., Blaine, M.C., Wallace, W.F. and Chen, R.S. Facilitation of Immune Function, Healing of Pressure Ulcers, and Nutritional Status in Spinal Cord Injury Patients Experimental & Molecular Pathology, 68: 38-54. 2000.
Cruse, J.M., Lewis, R.E., and Dilioglou, S Fate of Immune complexes, glomerulonephritis, and Cell-Mediated Vasculitis in Lupus-Prone MRL/Mp lpr/lpr Mice Experimental & Molecular Pathology, 69: 211-222., 2000.
Dilioglou, S., Cruse, J.M. and Lewis, R.E. Function of CD80 and CD86 on monocyte and stem cell-derived dendritic cells Experimental and Molecular Pathology. 75:217-227. 2003.
Lewis, R.E., Jr., Cruse, J.M. and J. Hazelwood Halothane-induced suppression of lymphocyte transformation in normal and tumor-bearing C3Hf/He mice Anesthesia and Analgesia 59:666-67l, 1980.
Diloglou, S., Cruse, J.M. and Lewis, R.E. High Panel Reactive Antibody Against Cross reactive Group Antigens as a Contraindication to Renal Allotransplantation Experimental & Molecular Pathology. 71:1 73-78. 2001
Lewis, R.E., Jr., Cruse, J.M., Johnson, W.W., and Mohammad, A Histopathology and cell-mediated immune reactivity in halothane associated lymphomagenesis and autoimmunity in BXSB/Mp and MRL/Mp mice. Experimental and Molecular Pathology, 36:378-395, l982.
Achord, A.P., Lewis, R.E., Brackin, M.N., Henderson, H. and Cruse, J.M. HIV-1 Disease Association with HLA-DQ Antigens in African Americans and Caucasians Pathobiology, 64:204-208, 1996.
Cruse, J.M., Brackin, M.N., Lewis, R.E., Meeks, W., Nolan, R., and Brackin, B HLA disease association and protection in HIV infection among African Americans and Caucasians. Pathobiology, vol. 59:324-328, 1991.
Achord, A.P., Lewis, R.E., Brackin, M.N. and Cruse, J.M HLA-DQB1 Markers Associated With HIV-1 Disease Progression. Pathobiology, 65:210-215., 1997.
Rubin, J., L.M. Lin, R.E. Lewis, Jr., J.M. Cruse and J.D. Bower Host defense mechanisms in continuous ambulatory peritoneal dialysis Clinical Nephrology, 20:l40-l44, l983.
Cruse, J.M., Lewis, R.E., Jr., Lockard, V.G., Feduccia, T.A., and Mohammad, A. Immune complex formation and resolution in systemic lupus erythematosus (SLE)-prone and non-SLE-prone mice Experimental and Molecular Pathology, 36:l-l8, l982.
Cruse, J.M., Keith, J.C., Bryant, M.L. and Lewis, R.E. Immune System - Neuroendocrine Dysregulation in Spinal Cord Injury. Immunologic Research, 15:306-314, 1996
Harisdangkul, V., C.J. Chen, R.E. Lewis, Jr., and J.M. Cruse Immunologic findings in Vogt-Koyanagi-Harada syndrome Internal Medicine for the Specialist, vol. 12, no. 6, pp 54-61, 1991.
Cruse, J.M., Lewis, R.E. and S.Dilioglou Immunological Enhancement Revisited. Experimental and Molecular Pathology. 73:112-127. 2002
Nilganuwonge, S., Harisdangkul, V., Rockhold, L., Lewis, R., and Cruse, J.M. Lymphocyte subset T4/T8 ratios in systemic lupus erythematosus: correlation with disease activity, laboratory abnormalities and treatment Asian Pacific Journal of Allergy & Immunology, 6:23-28, l988.
Cannon, S.S., W.W. Johnson, V.J. Lockard and R.E. Lewis, Jr Medullary carcinoma of the thyroid retrospective diagnosis using current techniques on late metastases Jour. Miss. Med. Assoc., XXVI:5-7, l985.
Cruse, J.M., Lewis, R.E., Bishop, G.R., Kliesch, W.F. and Gaitan, E Neuroendocrine-Immune Interactions Associated with Loss and Restoration of Immune System Function in Spinal Cord Injury and Stroke Patients Immunologic Research, 11:104-116, 1992
Lewis,R.E., Jr., W.W. Johnson, and J.M. Cruse Pitfalls and caveats in the methodology for immunoperoxidase staining in surgical pathologic diagnosis Survey and Synthesis of Pathology Research, l:l34-l52, l983.
Brackin, M.N., Lewis, R.E., Brackin, B.T., Achord, A., Henderson, H., Crawford, M. and Cruse, J.M. Progression of HIV Infection Is Associated With HLA-DQ Antigen in Caucasians and African Americans Pathobiology, 63: 22-41, 1995
Brackin, M.N., Cruse, J.M., Lewis, R.E., Hines, R.S., Stopple, J.A. and Cowan, B.D. Quantitative Analysis of Adhesion Molecules on Cellular constituents of the Human Uterine Microenvironment Under the Influence of Estrogen and Progesterone Experimental and Molecular Pathology. 72: 91-114. 2002
Harisdangkul, V., C.J. Chen, R.E. Lewis, Jr., and J.M. Cruse Relapsing polychondritis: Immunohistochemical evidence suggestive of an autoimmune disease Internal Medicine for the Specialist, 3:56-65, l982.
Kliesch, W.F., Cruse, J.M., Lewis, R.E., Bishop, G.R., Brackin, B. and Lampton, J.A. Restoration of Depressed Immune Function in Spinal Cord Injury Patients Receiving Rehabilitation Therapy Paraplegia, 34:82-90, 1996
Cruse,J.M, Lewis, R.E., Dilioglou, S., Rose, D., Wallace, W.F. and Chen, R. Review of Immune Function, Healing of Pressure Ulcers and Nutritional Status in Patients With Spinal Cord Injury. Journal of Spinal Cord Medicine. 23:2, 129-135. 2000.
Lewis, R.E., Jr. K. Kirchner, T. Preuss, S. Raju, R. Krueger, M. Cuchens, J.D. Bower and J.M. Cruse Serial monitoring of T cell subset ratios with monoclonal antibodies in steroid- and ATG-treated patients with renal allotransplants Clinical Immunology and Immunopathology, 31:241-253, 1984.
Lewis, R.E., Cruse, J.M., Pierce, S., Lam, J., Tadros, Y. Surface and Cytoplasmic Immunoglobulin Expression in B Cell Chronic Lymphocytic Leukemia (CLL). Experimental and Molecular Pathology. 79:146-150. 2005.
Harris, G.D., Cruse, J.M., Lewis, R.E., Jr., and Mohammad, A Termination of immunological tolerance in mice to human IgG by human IgA Experimental and Molecular Pathology, 36:373-377, l982.
Lewis, R.E., Cruse, J.M., Sanders, C.M., Webb, R.N., Tillman, B.F., Beason, K.L., Lam, F. and Koehler, J. The immunophenotype of pre-TALL/LBL Revisited. Experimental and Molecular Pathology. 81:(2)162-165. 2006.
Gaitan, E., R.C.Cooksey, J.M.Cruse, R.E.Lewis, R.H.Lindsay and R.L.Jolley The problem of goitrogenic substances in the presence of sufficient iodine supplementation. 2. Symposium interdisziplinare Probleme des Iodmangels, der Iodprophylaxe, des Iodexzesses und antithyreoidaler Substanzen. In: Aktuelle interdisziplinare Probleme Iodmangel Iodprophylaxe Iodexzess Antithyreoidale Substanzen. Gesellschaft fur Endokrinologie und Stoffwechselkrankheiten der DDR. Karl-Marx-Stadt, 1989
Sanders, CM, JM.Cruse, and R.E.Lewis Toll-like Receptors, Cytokines and HIV-1. Experimental and Molecular Pathology 84(1):31-36. 2008.
Cruse, JM, Lewis, R.E., Webb, RN, Sanders, CM, and Suggs, JL Zap-70 and CD38 AS Predictors of IgVH mutation in CLL. Experimental and Molecular Pathology. 83(3):459-461. 2007.

Review Article

Lewis, R.E., and J.M. Cruse Immunity, anesthesia and transplantation Part I; Effect of anesthesia and operation on host immune responsiveness Biomedia, Princeton, N.J. Anesthetist U. S. l2:l-8, 1978.
Lewis, R.E, Jr., and J.M. Cruse Immunity, anesthesia and transplantation Part II; Effect of anesthesia and operation on host immune responsiveness Biomedia, Princeton, NJ. Anesthetist U.S. l3:l-8, 1978.
Cruse, J.M. and R.E.Lewis,Jr Immunotherapy of cancer. EOS Rivista di Immunologia ed Immunofarmacologia. (EOS J.Immunol.Immunopharmacol.) IX:2, 41-53, 1989.