Lance E. Keller, PhD
Assistant Professor
Department:
SOM-Cell and Molecular Biology
Email:
lekeller@umc.edu
Work Phone:
(601) 984-1700
Education
| University of Lausanne, Postdoctoral Research, Bacteriology | 2020 |
| University of Groningen, Postdoctoral Research, Bacteriology | 2017 |
| University of Mississippi Medical Center, PhD, Microbiology and Immunology | 2015 |
| University of Mississippi Medical Center, MS, Biomedical Sciences | 2012 |
| Southwestern University, BA, Biology | 2009 |
Current Positions
| Assistant Professor, School of Medicine | 06/2020 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Postdoctoral Researcher, University of Lausanne | 03/2017 - 05/2020 |
| Postdoctoral Researcher, University of Groningen | 05/2015 - 02/2017 |
Sponsored Program Funding
| Extramural, Competence Machinery of Streptococcus pneumoniae as a way for in vivo de novo DNA Sequencing, DARPA | 08/2017 - 07/2018 |
Publications
Journal Article | |
| Wu X, Alibayov B, Xiang X, Lattar SM, Sakai F, Medders AA, Antezana BS, Keller LE, Vidal AG, Tzeng YL, Robinson DA, Stephens DS, Yunsong Y, and Vidal JE Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae Drug Resistance Updates, 101138 | 2024 |
| Alcorlo M, Abdullah MR, Steil L, Sotomayor F, López-de Oro L, de Castro S, Velázquez S, Kohler TP, Jiménez E, Medina A, Usón I,; Keller LE, Bradshaw JL, McDaniel LS, María-José C, Völker U, Hammerschmidt S, Hermoso JA Molecular and structural basis of oligopeptide recognition by the Ami transporter system in pneumococci. PLoS pathogens, 20(6), e1011883. | 2024 |
| Thompson CD, Bradshaw JL, Miller WS, Vidal AGJ, Vidal JE, Rosch JW, McDaniel LS, and Keller LE Oligopeptide Transporters of Nonencapsulated Streptococcus pneumoniae Regulate CbpAC and PspA Expression and Reduce Complement-Mediated Clearance Mbio. 2023; e03325-22 | 2023 |
| Keller LE, Rueff AS, Kurushima J, Veening JW Three new integration vectors and fluorescent proteins for use in the opportunistic human pathogen Streptococcus pneumoniae. Genes. 2019 May;10(5):394 | 2019 |
| Bradshaw JL, Pipkins HR, Keller LE, Pendarvis JK, McDaniel LS Mucosal Infections and Invasive Potential of Nonencapsulated Streptococcus pneumoniae Are Enhanced by Oligopeptide Binding Proteins AliC and AliD mBio. 2018 Mar 7;9(1):e02097-17 | 2018 |
| Pipkins HR, Bradshaw JL, Keller LE, McDaniel LS Increased Virulence of an Encapsulated Streptococcus pneumoniae Upon Expression of Pneumococcal Surface Protein K The Journal of Infectious Diseases. 2018 Jan 31;217(10):1637-44 | 2018 |
| Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Lamkanfi M, Trottein F, and Paget C Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections Mucosal immunology. 2017 Jul;10(4):1056-68 | 2017 |
| Pipkins HR, Bradshaw JL, Keller LE, Swiatlo E, McDaniel LS Polyamine transporter potABCD is required for virulence of encapsulated but not nonencapsulated Streptococcus pneumoniae PloS one. 2017 Jun 6;12(6):e0179159 | 2017 |
| Dixit C, Keller LE, Bradshaw JL, Robinson DA, Swiatlo E, McDaniel LS Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis IDCases. 2016 Dec 31;4:56-8 | 2016 |
| Keller LE, Bradshaw JL, Pipkins H, McDaniel LS Surface Proteins and Pneumolysin of Encapsulated and Nonencapsulated Streptococcus pneumoniae Mediate Virulence in a Chinchilla Model of Otitis Media Frontiers in cellular and infection microbiology. 2016 May 18;6:55 | 2016 |
| Brown LR, Gunnell SM, Cassella AN, Keller LE, Scherkenbach LA, Mann B, Brown MW, Hill R, Fitzkee NC, Rosch JW, Tuomanen EI AdcAII of Streptococcus pneumoniae Affects Pneumococcal Invasiveness PloS one. 2016 Jan 11;11(1):e0146785 | 2016 |
| Keller LE, Luo X, Thornton JA, Seo KS, Moon BY, Robinson DA, McDaniel LS Immunization with Pneumococcal Surface Protein K of Nonencapsulated Streptococcus pneumoniae Provides Protection in a Mouse Model of Colonization Clinical and Vaccine Immunology. 2015 Nov;22(11):1146-53 | 2015 |
| Keller LE, Friley J, Dixit C, Nahm MH, McDaniel LS Nonencapsulated Streptococcus pneumoniae cause acute otitis media in the chinchilla that is enhanced by pneumococcal surface protein K Open Forum Infectious Diseases 2014 Sep 1 (Vol. 1, No. 2) | 2014 |
| Keller LE, Thomas JC, Luo X, Nahm MH, McDaniel LS, Robinson DA Draft genome sequences of five multilocus sequence types of nonencapsulated Streptococcus pneumoniae Genome announcements. 2013 Aug 29;1(4):e00520-13 | 2013 |
| Keller LE, Jones CV, Thornton JA, Sanders ME, Swiatlo E, Nahm MH, Park IH, McDaniel LS PspK of Streptococcus pneumoniae increases adherence to epithelial cells and enhances nasopharyngeal colonization Infection and immunity. 2013 Jan;81(1):173-81 | 2013 |
Review Article | |
| Keller LE, Robinson DA, McDaniel LS Nonencapsulated Streptococcus pneumoniae: emergence and pathogenesis mBio. 2016 May 4;7(2):e01792-15 | 2016 |
Book Chapter | |
| Lance E Keller Single-species and multispecies biofilms causing infections Microbial Biofilms (pp. 39-53). Academic Press. | 2024 |
Presentations
| Poster Presentation, Oligopeptide Transporters of Streptococcus pneumoniae Increase Resistance to β-lactam Antibiotics Through Altered Cell Wall Structure, ISPPD, Cape Town, South Africa | 03/2024 |
| Invited Symposia, Division of Health Sciences Interactive Workshop on Gene Editing, Mississippi Academy of Sciences, Biloxi, MS | 02/2023 |
| Oral Presentation, Morphological Variations of Streptococcus pneumoniae and the Impact on Virulence in a Larval Model of Infection, MAS, Biloxi, MS | 04/2022 |
| Poster Presentation, AliC and AliD regulation of C Reactive Protein Binding to Nonencapsulated Streptococcus pneumoniae and its Effect on Systemic Survival, MAS, Biloxi, MS | 04/2022 |
| Oral Presentation, AliC and AliD of Nonencapsulated Streptococcus pneumoniae Regulate CbpAC Expression and Reduce Complement Mediated Clearance, MAS, Biloxi, MS | 04/2022 |
| Poster Presentation, Nonencapsulated Streptococcus pneumoniae cause Bacteremia by Blocking Binding of C-Reactive Protein, ACAAI, New Orleans, LA | 11/2021 |
| Oral Presentation, AliC and AliD of Nonencapsulated Streptococcus pneumoniae alter lytA and mgtC expression and reduce virulence in a Galleria mellonella model of infection, MAS, Biloxi, MS | 08/2021 |
| Poster Presentation, Synthetic Gene Regulatory Networks in Streptococcus pneumoniae for the Production of Heterogeneous Populations, ASM, Washington D.C., USA | 08/2016 |
| Poster Presentation, Pathogenesis of Nonencapsulated Streptococcus pneumoniae in a Chinchilla Model of Otitis Media, ICAAC, Washington D.C., USA | 09/2014 |
| Poster Presentation, PspK Enhances Acute Otitis Media Caused by Nonencapsulated Streptococcus pneumoniae in the Chinchilla, ASM, Boston, MA | 05/2014 |
| Poster Presentation, Nonencapsulated Streptococcus pneumoniae cause Otitis Media in the Chinchilla Modl and PspK is Required for Persistent Colonization of the Mouse Nasopharynx, CSHL, Cold Spring Harbor, NY | 09/2013 |
| Poster Presentation, PspK+ Nonencapsulated Streptococcus pneumoniae Persistently Colonizes the Mouse Nasopharynx but has Reduced Competitiveness when Compared to Encapsulated Pneumococci, ASM, Denver, CO | 05/2013 |
| Oral Presentation, Nonencapsulated Streptococcus pneumoniae Competes Against Encapsulated Pneumococci, ASM South Central, Starkville, MS | 05/2013 |
| Poster Presentation, PspK of Streptococcus pneumoniae Binds sIgA and Increases Pneumococcal Cell Adhesion, ASM, San Francisco, CA | 06/2012 |
| Poster Presentation, Requirement of a C-terminal 22 Amino Acid Sequence within the Escherichia coli UmuC Protein Necessary for Lon-mediated Degradation, Molecular Genetics of Bacteria and Phages, Madison, WI | 08/2011 |
| Oral Presentation, C-terminal 22 Amino Acid Sequence within the Escherichia coli UmuC protein Required for Lon-mediated Degradation, ASM Texas, New Braunsful, TX | 04/2009 |
Honors, Awards, and Recognition
| Travel Award, American Society for Microbiology | 2016 |
| Outstanding Young Research Award, University of Mississippi Medical Center | 2015 |
| Dean's Scholarship, University of Mississippi Medical Center | 2014 |
Professional Membership and Service
| Mississippi Academy of Science, Member | 2021 |
| American Society for Microbiology, Member | 2011 |
Committee Service
| Health Sceinces Division Committee Member, Vice Chair | 2022 - Present |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-MD/PHD ADVISORY, Member | 2022 - Present |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-MD/PHD ADVISORY, Member | 2022 - Present |
| Institutional Review Board for Veterans Affairs Hospital, Member | 2020 - Present |
Other Service
| Frontiers in Cellular and Infection Microbiology | 08/2023 - Present |
| Microorganisms Review Board Member | 08/2021 - Present |
| MAS Judge and Moderator | 2021 - Present |
| SNSF Reviewer | 10/2020 - 12/2020 |
Teaching Experience
| Micro611, Medicine, Lab, Lab Director, Medical Microbiology Lab | Fall 2023 |
| MICRO 741, Graduate, Course, Lecturer, Fundamentals of Microbiology | Spring 2022 |
| MICRO 707, Graduate, Lab, Lab Director, Graduate Student Rotations | Summer 2021 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology | Fall 2021 |
| MICRO 741, Graduate, Course, Lecturer, Fundamentals in Microbiology | Spring 2021 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology Lab | Fall 2021 |
| DENT 641, Dentistry, Course, Lecturer, Dental Microbiology | Fall 2021 |
| MICRO 725, Graduate, Course, Lecturer, Bacterial Structure and Function | Spring 2021 |
| MICRO 611, Medicine, Small Group, Facilitator, Medical Microbiology | Fall 2020 |
| DENT 641, Dentistry, Course, Lecturer, Dental Microbiology | Fall 2020 |
| MICRO 611, Medicine, Lab, Facilitator, Medical Microbiology Lab | Fall 2020 |
Directed Student Learning
| Research Advisor, Advised: Fahim Khan | 2023 - Present |
| Research Advisor, Advised: Lucas Crosby | 2023 - Present |
| Dissertation Committee Member, Advised: John Crawford | 2022 - Present |
| Dissertation Committee Member, Advised: Mary Carr | 2022 - 2024 |
| Dissertation Committee Member, Advised: Anna Scasny | 2022 - 2024 |
| Supervised Research, Advised: Kenyatta Poe | 2021 - 2021 |
| Supervised Research, Advised: Wesley Miller | 2021 - 2021 |
| Dissertation Committee Member, Advised: Courtney Thompson | 2021 - 2023 |
| Research Advisor, Advised: Vishwachi Tripathi | 2017 - 2018 |
| Research Advisor, Advised: Paul Stege | 2015 - 2016 |
| Research Advisor, Advised: Claresa Youngblood | 2013 - 2013 |
| Research Advisor, Advised: Cheshil Dixit | 2013 - 2015 |