Amol Janorkar, PhD

Amol Janorkar, PhD

Chair

Department:
SOD-Biomedical Mtrls Science

Email:
ajanorkar@umc.edu

Work Phone:
(601) 984-6170

Biography

Amol V. Janorkar received his B.S. in chemical engineering from University of Mumbai Department of Chemical Technology (UDCT) in 2000 and his Ph.D. in chemical engineering from Clemson University in 2005. Subsequently, he did a two-year postdoctoral research fellowship at the Center for Engineering in Medicine with a joint appointment at the Harvard Medical School, Massachusetts General Hospital, and Shriners Hospital for Children. He joined the faculty of the Department of Biomedical Materials Science, School of Dentistry at the University of Mississippi Medical Center (UMMC) in August 2007 as an Assistant Professor. Dr. Janorkar was promoted to the rank of Associate Professor (with tenure) in July 2013 and then to the rank of Professor in July 2017. Beginning in July 2020, Dr. Janorkar was entrusted with the responsibility of being the Chairperson for the Department of Biomedical Materials Science. In his other administrative service roles, Dr. Janorkar is serving as the Professional Development Liaison for the School of Dentistry, the Chair of the UMMC Intellectual Property Committee, and the Co-Director of the NIH-funded Mississippi Center for Clinical and Translational Research (MCCTR) Mentoring Academy.

With his training and experience in the field of biomaterials and tissue engineering, Dr. Janorkar leads a research group that focuses on cell-biomaterial interactions to direct cell morphology and ultimate cell function. The Janorkar Lab uses chemical and physical modification of biopolymer substrates to create three-dimensional in vitro tissue models that achieve enhanced survival and biological function versus conventional cultures for liver, adipose, and bone tissue engineering. His research has been funded by the National Science Foundation (NSF), the National Institutes of Health (NIDCR and NIBIB), and the United States Department of Agriculture (USDA). Dr. Janorkar has published over 80 journal articles and 50 conference proceedings. Dr. Janorkar and his students have made over 200 research presentations. Recognizing these research accomplishments, the University of Mississippi Medical Center has awarded Dr. Janorkar the Gold, Silver, and Bronze Medallions for Research Excellence.

Dr. Janorkar served as the founding Director of School of Dentistry’s summer research program that has trained over 250 dental and undergraduate students over 15 years (2008-2023). Recognizing his contributions to dental research, he has been inducted into the Omicron Kappa Upsilon National Dental Honor Society, which rarely inducts non-dentist faculty members. Dr. Janorkar also served as the Director of the Ph.D. graduate program with focus on Biomedical Materials Science from 2016-2020. He continues to serve as the director and course faculty for several dental and graduate courses. Dr. Janorkar has mentored over 80 graduate, undergraduate, dental, and medical students and post-docs. His students have won 44 awards for outstanding research at local and national levels. Recognizing his teaching and mentoring, Dr. Janorkar was awarded the TEACH (Toward Educational Advancement in Care and Health) Prize, the highest award given to an educator by the University of Mississippi Medical Center. He has also been inducted into the Nelson Order of Teaching Excellence and the UMMC Academy for Excellence in Education (AEE). Dr. Janorkar currently serves as the President of the AEE.

Dr. Janorkar is a senior member of the American Institute of Chemical Engineers (AIChE) and an active member of the Society for Biomaterials (SFB) and the American Association for Dental, Oral, and Craniofacial Research (AADOCR).

Education

Clemson University, Clemson, SC, USA, PhD, Chemical Engineering2005
Mumbai University Department of Chemical Technology (U.D.C.T.), Mumbai, India, BS, Chemical Engineering2000

Academic Appointments or Other Previous Appointments

School of Dentistry, Department of Biomedical Materials Science

Publications

Journal Article

Ali A, Polepalli L, Chowdhury S, Carr MA, Janorkar AV, Marquart ME, Griggs JA, Bumgardner JD, Roach MD, Silver-Doped Titanium Oxide Layers for Improved Photocatalytic Activity and Antibacterial Properties of Titanium Implants. Journal of functional biomaterials, 2024 Jun 14;15(6)2024
Pal P, Medina A, Chowdhury S, Cates CA, Bollavarapu R, Person JM, McIntyre B, Speed JS, Janorkar AV, Influence of the Tissue Collection Procedure on the Adipogenic Differentiation of Human Stem Cells: Ischemic versus Well-Vascularized Adipose Tissue. Biomedicines, 2024 May 1;12(5)2024
Pal P, Maranon RO, Rivera Gonzales OJ, Speed JS, Janorkar AV, Sexual Dimorphism's impact on adipogenesis: A three-dimensional in vitro model treated with 17β-estradiol and testosterone. Molecular and cellular endocrinology, 2024 Aug 1;589:1122492024
Kalluri L, Griggs JA, Janorkar AV, Xu X, Chandran R, Mei H, Nobles KP, Yang S, Alberto L, Duan Y, Preparation and optimization of an eggshell membrane-based biomaterial for GTR applications. Dental materials : official publication of the Academy of Dental Materials, 2024 Apr;40(4):728-7382024
Ali A, Chowdhury S, Carr MA, Janorkar AV, Marquart M, Griggs JA, Bumgardner JD, Roach MD, Antibacterial and biocompatible polyaniline-doped titanium oxide layers. Journal of biomedical materials research. Part B, Applied biomaterials, 2023 May;111(5):1100-11112023
Pal P, Tucci MA, Fan LW, Bollavarapu R, Lee JW, Salazar Marocho SM, Janorkar AV, Functionalized Collagen/Elastin-like Polypeptide Hydrogels for Craniofacial Bone Regeneration. Advanced healthcare materials, 2023 Mar;12(8):e22024772023
Ali A, Chowdhury S, Janorkar A, Marquart M, Griggs JA, Bumgardner J, Roach MD, A novel single-step anodization approach for PANI-doping oxide surfaces to improve the photocatalytic activity of titanium implants. Biomedical materials (Bristol, England), 2022 Nov 16;2022
Dragojevic S, Turner L, Pal P, Janorkar AV, Raucher D, Elastin-like Polypeptide Hydrogels for Tunable, Sustained Local Chemotherapy in Malignant Glioma. Pharmaceutics, 2022 Sep 28;14(10)2022
Nobles KP, Janorkar AV, Williamson RS, Surface modifications to enhance osseointegration-Resulting material properties and biological responses. Journal of biomedical materials research. Part B, Applied biomaterials, 2021 Nov;109(11):1909-19232021
Cobb JS, Rourke AS, Creel A, Janorkar AV, Manipulating the solution environment to control the surface roughness of elastin-based polymer coatings. Journal of biomaterials applications, 2021 Sep;36(3):419-4272021
Tucker LJ, Grant CS, Gautreaux MA, Amarasekara DL, Fitzkee NC, Janorkar AV, Varadarajan A, Kundu S, Priddy LB, Physicochemical and Antimicrobial Properties of Thermosensitive Chitosan Hydrogel Loaded with Fosfomycin. Marine drugs, 2021 Mar 6;19(3)2021
Cobb JS, Engel A, Seale MA, Janorkar AV, Machine learning to determine optimal conditions for controlling the size of elastin-based particles. Scientific reports, 2021 Mar 18;11(1):63432021
Cobb JS, Seale MA, Janorkar AV, Evaluation of machine learning algorithms to predict the hydrodynamic radii and transition temperatures of chemo-biologically synthesized copolymers. Computers in biology and medicine, 2021 Jan;128:1041342021
Qu J, Guillory D, Cheah P, Tian B, Zheng J, Liu Y, Cates C, Janorkar AV, Zhao Y, Synthesis of Biomimetic Melanin-Like Multifunctional Nanoparticles for pH Responsive Magnetic Resonance Imaging and Photothermal Therapy. Nanomaterials (Basel, Switzerland), 2021 Aug 19;11(8)2021
Newman K, Clark K, Gurumurthy B, Pal P, Janorkar AV, Elastin-Collagen Based Hydrogels as Model Scaffolds to Induce Three-Dimensional Adipocyte Culture from Adipose Derived Stem Cells. Bioengineering (Basel, Switzerland), 2020 Sep 12;7(3)2020
Fitzgerald SJ, Cobb JS, Janorkar AV, Comparison of the formation, adipogenic maturation, and retention of human adipose-derived stem cell spheroids in scaffold-free culture techniques. Journal of biomedical materials research. Part B, Applied biomaterials, 2020 Oct;108(7):3022-30322020
Cobb JS, Zai-Rose V, Correia JJ, Janorkar AV, FT-IR Spectroscopic Analysis of the Secondary Structures Present during the Desiccation Induced Aggregation of Elastin-Like Polypeptide on Silica. ACS omega, 2020 Apr 14;5(14):8403-84132020
Gurumurthy B, Pal P, Griggs JA, Janorkar AV, OPTIMIZATION OF COLLAGEN-ELASTIN-LIKE POLYPEPTIDE-BIOGLASS SCAFFOLD COMPOSITION FOR OSTEOGENIC DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS. Materialia, 2020 Mar;92020
Gurumurthy B, Tucci MA, Fan LW, Benghuzzi HA, Pal P, Bidwell GL, Salazar Marocho SM, Cason Z, Gordy D, Janorkar AV, Collagen-Elastin-Like Polypeptide-Bioglass Scaffolds for Guided Bone Regeneration. Advanced healthcare materials, 2020 Feb;9(4):e19013852020
Pal P, Nguyen QC, Benton AH, Marquart ME, Janorkar AV, Drug-Loaded Elastin-Like Polypeptide-Collagen Hydrogels with High Modulus for Bone Tissue Engineering. Macromolecular bioscience, 2019 Sep;19(9):e19001422019
Jain S, Williamson RS, Janorkar AV, Griggs JA, Roach MD, Osteoblast response to nanostructured and phosphorus-enhanced titanium anodization surfaces. Journal of biomaterials applications, 2019 Sep;34(3):419-4302019
Fitzgerald SJ, Janorkar AV, Barnes A, Maranon RO, A new approach to study the sex differences in adipose tissue. Journal of biomedical science, 2018 Dec 3;25(1):892018
Clark K, Janorkar AV, Milieu for Endothelial Differentiation of Human Adipose-Derived Stem Cells. Bioengineering (Basel, Switzerland), 2018 Oct 3;5(4)2018
Cobb JS, Zai-Rose V, Correia JJ, Janorkar AV, Visualization of the temperature dependent rearrangement of SynB1 elastin-like polypeptide on silica using scanning electron microscopy. Analytical biochemistry, 2018 Oct 1;558:41-492018
Gurumurthy B, Griggs JA, Janorkar AV, Optimization of collagen-elastin-like polypeptide composite tissue engineering scaffolds using response surface methodology. Journal of the mechanical behavior of biomedical materials, 2018 Aug;84:116-1252018
Turner PA, Garrett MR, Didion SP, Janorkar AV, Spheroid Culture System Confers Differentiated Transcriptome Profile and Functional Advantage to 3T3-L1 Adipocytes. Annals of biomedical engineering, 2018 May;46(5):772-7872018
Jain S, Williamson RS, Marquart M, Janorkar AV, Griggs JA, Roach MD, Photofunctionalization of anodized titanium surfaces using UVA or UVC light and its effects against Streptococcus sanguinis. Journal of biomedical materials research. Part B, Applied biomaterials, 2018 Aug;106(6):2284-22942018
Turner PA, Gurumurthy B, Bailey JL, Elks CM, Janorkar AV, Adipogenic Differentiation of Human Adipose-Derived Stem Cells Grown as Spheroids. Process biochemistry (Barking, London, England), 2017 Aug;59:312-3202017
Gurumurthy B, Bierdeman PC, Janorkar AV, Spheroid model for functional osteogenic evaluation of human adipose derived stem cells. Journal of biomedical materials research. Part A, 2017 Apr;105(4):1230-12362017
Penfornis P, Vallabhaneni KC, Janorkar AV, Pochampally RR, Three dimensional tumor models for cancer studies. Frontiers in bioscience (Elite edition), 2017 Jan 1;9(1):162-1732017
Weeks CA, Aden B, Zhang J, Singh A, Hickey RD, Kilbey SM 2nd, Nyberg SL, Janorkar AV, Effect of amine content and chemistry on long-term, three-dimensional hepatocyte spheroid culture atop aminated elastin-like polypeptide coatings. Journal of biomedical materials research. Part A, 2017 Feb;105(2):377-3882017
Weeks CA, Aden B, Kilbey SM 2nd, Janorkar AV, Synthesis and Characterization of an Array of Elastin-like Polypeptide-Polyelectrolyte Conjugates with Varying Chemistries and Amine Content for Biomedical Applications. ACS biomaterials science & engineering, 2016 Dec 12;2(12):2196-22062016
Gurumurthy B, Bierdeman PC, Janorkar AV, Composition of elastin like polypeptide-collagen composite scaffold influences in vitro osteogenic activity of human adipose derived stem cells. Dental materials : official publication of the Academy of Dental Materials, 2016 Oct;32(10):1270-12802016
Turner PA, Tang Y, Weiss SJ, Janorkar AV, Three-dimensional spheroid cell model of in vitro adipocyte inflammation. Tissue engineering. Part A, 2015 Jun;21(11-12):1837-472015
Anderson TR, Marquart ME, Janorkar AV, Effective release of a broad spectrum antibiotic from elastin-like polypeptide-collagen composite. Journal of biomedical materials research. Part A, 2015 Feb;103(2):782-902015
Adams TN, Turner PA, Janorkar AV, Zhao F, Minerick AR, Characterizing the dielectric properties of human mesenchymal stem cells and the effects of charged elastin-like polypeptide copolymer treatment. Biomicrofluidics, 2014 Sep;8(5):0541092014
Turner PA, Harris LM, Purser CA, Baker RC, Janorkar AV, A surface-tethered spheroid model for functional evaluation of 3T3-L1 adipocytes. Biotechnology and bioengineering, 2014 Jan;111(1):174-832014
Turner PA, Weeks CA, McMurphy AJ, Janorkar AV, Spheroid organization kinetics of H35 rat hepatoma model cell system on elastin-like polypeptide-polyethyleneimine copolymer substrates. Journal of biomedical materials research. Part A, 2014 Mar;102(3):852-612014
Patel NU, Purser CA, Baker RC, Janorkar AV, Effect of processing temperature on the morphology and drug-release characteristics of elastin-like polypeptide-collagen composite coatings. Biomacromolecules, 2013 Aug 12;14(8):2891-92013
Wheeler TS, Sbravati ND, Janorkar AV, Mechanical & cell culture properties of elastin-like polypeptide, collagen, bioglass, and carbon nanosphere composites. Annals of biomedical engineering, 2013 Oct;41(10):2042-552013
Weeks CA, Newman K, Turner PA, Rodysill B, Hickey RD, Nyberg SL, Janorkar AV, Suspension culture of hepatocyte-derived reporter cells in presence of albumin to form stable three-dimensional spheroids. Biotechnology and bioengineering, 2013 Sep;110(9):2548-552013
Amruthwar SS, Puckett AD, Janorkar AV, Preparation and characterization of novel elastin-like polypeptide-collagen composites. Journal of biomedical materials research. Part A, 2013 Aug;101(8):2383-912013
Amruthwar SS, Janorkar AV, In vitro evaluation of elastin-like polypeptide-collagen composite scaffold for bone tissue engineering. Dental materials : official publication of the Academy of Dental Materials, 2013 Feb;29(2):211-202013
Amruthwar SS, Janorkar AV, Preparation and characterization of elastin-like polypeptide scaffolds for local delivery of antibiotics and proteins. Journal of materials science. Materials in medicine, 2012 Dec;23(12):2903-122012
Janorkar AV, Harris LM, Murphey BS, Sowell BL, Use of three-dimensional spheroids of hepatocyte-derived reporter cells to study the effects of intracellular fat accumulation and subsequent cytokine exposure. Biotechnology and bioengineering, 2011 May;108(5):1171-802011
Janorkar AV, King KR, Megeed Z, Yarmush ML, Development of an in vitro cell culture model of hepatic steatosis using hepatocyte-derived reporter cells. Biotechnology and bioengineering, 2009 Apr 1;102(5):1466-742009
Swierczewska M, Hajicharalambous CS, Janorkar AV, Megeed Z, Yarmush ML, Rajagopalan P, Cellular response to nanoscale elastin-like polypeptide polyelectrolyte multilayers. Acta biomaterialia, 2008 Jul;4(4):827-372008
Janorkar AV, Rajagopalan P, Yarmush ML, Megeed Z, The use of elastin-like polypeptide-polyelectrolyte complexes to control hepatocyte morphology and function in vitro. Biomaterials, 2008 Feb;29(6):625-322008
Janorkar AV, Fritz EW Jr, Burg KJ, Metters AT, Hirt DE, Grafting amine-terminated branched architectures from poly(L-lactide) film surfaces for improved cell attachment. Journal of biomedical materials research. Part B, Applied biomaterials, 2007 Apr;81(1):142-522007
Janorkar AV, Luo N, Hirt DE, Surface modification of an ethylene-acrylic acid copolymer film: grafting amine-terminated linear and branched architectures. Langmuir : the ACS journal of surfaces and colloids, 2004 Aug 17;20(17):7151-82004
Johnson HA, Williamson RS, Marquart M, Bumgardner JD, Janorkar AV, Roach MD, Photocatalytic activity and antibacterial efficacy of UVA-treated titanium oxides. Journal of biomaterials applications, 2020 Oct-Nov;35(4-5):500-514

Editorial

Janorkar A, Marañón RO, Editorial: Sex differences in adiposity and cardiovascular disease. Frontiers in global women's health, 2023;4:1177718
Janorkar AV, Nalls K, Koka S, Leadership capabilities to establish a successful research program of any size in any place. Journal of prosthodontic research, 2022;66(3):viii-xi

Honors, Awards, and Recognition

President, Academy for Teaching Excellence, Univ of Mississippi Medical Center, Jackson, MS2024
Keynote Speaker, International Association for Dental Research (IADR) Annual Meeting, New Orleans, LA2024
Member, Sigma-Xi – The Academic Honor Society2022
President-Elect, Academy for Teaching Excellence, Univ of Mississippi Medical Center, Jackson, MS2022
Inducted into the Academy for Teaching Excellence, Univ of Mississippi Medical Center, Jackson, MS2022
Plenary Speaker, 37th Southern Biomedical Engineering Conference, New Orleans, LA2021
President, Omicron Kappa Upsilon National Dental Honor Society, Rho Sigma Chapter2021
Vice President, Omicron Kappa Upsilon National Dental Honor Society, Rho Sigma Chapter2020
Artwork selected as front cover image of ACS Omega, Vol. 5, Issue 14, March 2020., ACS Omega2020
Inventor Award, 2019 Intellectual Property Recognition Ceremony, Univ of Mississippi Medical Center, Jackson, MS2019
Artwork selected as back cover image of Macromolecular Bioscience, Vol. 19, Issue 9, September 2019., Macromolecular Bioscience2019
Outstanding Young Alumni Award, College of Engineering, Computing and Applied Sciences, Clemson University, Clemson, SC2019
Gold Medallion for Research Excellence, Univ of Mississippi Medical Center, Jackson, MS2018
The Regions Bank TEACH (Toward Educational Advancement in Care and Health) Prize (This prize celebrates the highest qualities of the UMMC teaching faculty. The winner receives a cash award, recognition at the luncheon honoring Nelson Order inductees, and public recognition at the UMMC commencement ceremony.), Univ of Mississippi Medical Center, Jackson, MS2018
Nelson Order of Teaching Excellence, Univ of Mississippi Medical Center, Jackson, MS2018
Honorary Faculty Member Inductee, Omicron Kappa Upsilon National Dental Honor Society2018
Silver Medallion for Research Excellence, Univ of Mississippi Medical Center, Jackson, MS2014
Bronze Medallion for Research Excellence, Univ of Mississippi Medical Center, Jackson, MS2011