Sung-Ho Huh
Assistant Professor
Department:
SOM-Otolaryngology - Head and Neck Surgery
Email:
shuh@umc.edu
Work Phone:
(601) 984-5162
Education
| Washington University in St. Louis, Department of Developmental Biology | 2012 |
| Washington University in St. Louis, PhD, Molecular Cell Biology program in DBBS | 2009 |
| Korea University, Seoul, Korea, Researcher in Cell Death Research Center | 2002 |
| Korea University Seoul, Korea., MS, Graduate School of Biotechnology | 2001 |
| Korea University Seoul, Korea., BS, Genetic Engineering | 1999 |
Current Positions
| Assistant Professor, School of Medicine | 2023 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Ting Therapeutics, School of Medicine | 07/2022 - 12/2022 |
| Assistant Professor, University of Nebraska Medical Center, School of Medicine | 2016 - 06/2022 |
| Instructor, Washington University, School of Medicine | 11/2012 - 12/2015 |
Sponsored Program Funding
| Extramural, National Institute of Health | 09/2025 - 07/2026 |
| Intramural, IRSP | 11/2023 - 11/2024 |
| Extramural, Child Health Research lnstitute Grant | 01/2021 - 12/2022 |
| Extramural, DHHS Nebraska State | 07/2018 - 06/2019 |
| Extramural, Pilot Grant, UAB The Hepato/Ranal Fibrocystic Disease Core Center | 07/2018 - 06/2020 |
| Extramural, Edna lttner Pediatric Research Grant | 11/2016 - 10/2017 |
| Extramural, CoBRE Pilot Award | 09/2016 - 08/2018 |
| Extramural, K99/R00 NIH Pathway to lndependence | 07/2013 - 12/2019 |
| Extramural, Hearing Health Foundation Research Grant renewal | 07/2011 - 06/2013 |
Publications
Journal Article | |
| Ebeid M, Kishimoto I, Roy P, Zaidi MAA, Cheng AG, Huh SH β-Catenin transcriptional activity is required for establishment of inner pillar cell identity during cochlear development. PLoS Genet. 2023 Aug;19(8):e1010925 | 2023 |
| Willet SG, Thanintorn N, McNeill H, Huh SH, Ornitz DM, Huh WJ, Hoft SG, DiPaolo RJ, Mills JC SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cell Mol Gastroenterol Hepatol. 2023;16(3):325-339 | 2023 |
| Ebeid M, Kishimoto I, Roy P, Zaidi MAA, Cheng AG, Huh SH, β-Catenin transcriptional activity is required for establishment of inner pillar cell identity during cochlear development. PLoS genetics, 2023 Aug;19(8):e1010925 | 2023 |
| Xue W, Kong Y Abu R, Roy P, Huh SH, Kuss M, Kumar V, Duan B. Regulation of Schwann Cell and DRG Neurite Behaviors within Decellularized Peripheral Nerve Matrix. ACS Appl Materlnterfaces. 2022 Feb 23;14(7):8693-8704 | 2022 |
| Xue W, Kong Y, Abu R, Roy P, Huh SH, Kuss M, Kumar V, Duan B, Regulation of Schwann Cell and DRG Neurite Behaviors within Decellularized Peripheral Nerve Matrix. ACS applied materials & interfaces, 2022 Feb 23;14(7):8693-8704 | 2022 |
| Li H, Kurtzeborn K, Kupari J, Gui Y Siefker E, Lu B, Mdtlik K, Olfat S, Montano-Rodriguez AR, Huh SH, Costantini F, Andressoo JO, Kuure S. Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development, 2021 May 15;148(10) | 2021 |
| Li H, Kurtzeborn K, Kupari J, Gui Y, Siefker E, Lu B, Mätlik K, Olfat S, Montaño-Rodríguez AR, Huh SH, Costantini F, Andressoo JO, Kuure S, Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development (Cambridge, England), 2021 May 15;148(10) | 2021 |
| Ebeid M, Huh SH. Mesenchymal ETV transcription factors regulate cochlear length. Hear Res. 2020 Aug 20;396;1 08039 | 2020 |
| Huh SH., Ha L, Jang HS Nephron Progenitor Maintenance ls Controlled through Fibroblast Growth Factors and Sproutyl lnteraction. J Am Soc Nephrol 2020 Aug 4;ASN.2020040401 | 2020 |
| Ebeid M, Huh SH, Mesenchymal ETV transcription factors regulate cochlear length. Hearing research, 2020 Oct;396:108039 | 2020 |
| Huh SH, Ha L, Jang HS, Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction. Journal of the American Society of Nephrology : JASN, 2020 Nov;31(11):2559-2572 | 2020 |
| Jansson L, Ebeid M, Shen JW, Mokhtari TE, Quiruz LA, Ornitz DM, Huh SH., Cheng AG.. β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21054-21060 | 2019 |
| Yang LM, Cheah KSE, Huh SH*, OrniE DM.. Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner. PLoS Genet. 2019 Jul;15(7):e 1008254 | 2019 |
| Jansson L, Ebeid M, Shen JW, Mokhtari TE, Quiruz LA, Ornitz DM, Huh SH, Cheng AG, β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea. Proceedings of the National Academy of Sciences of the United States of America, 2019 Oct 15;116(42):21054-21060 | 2019 |
| Yang LM, Cheah KSE, Huh SH, Ornitz DM, Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner. PLoS genetics, 2019 Jul;15(7):e1008254 | 2019 |
| Yang LM, Huh SH, Ornitz DM. FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area. Dev Cell 2018 Sep 10;46(5):564-580 | 2018 |
| Yang LM, Huh SH, Ornitz DM, FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area. Developmental cell, 2018 Sep 10;46(5):564-580.e5 | 2018 |
| Elo T, Lindfors PH, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Orni2 DM, Poutanen M, Howard BA, Mikkola ML. Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty Sci Rep.2017Jul 1I ;7(1):5049 | 2017 |
| Ebeid M, Huh SH, FGF signaling: diverse roles during cochlear development. BMB reports, 2017 Oct;50(10):487-495 | 2017 |
| Elo T, Lindfors PH, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Ornitz DM, Poutanen M, Howard BA, Mikkola ML, Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty. Scientific reports, 2017 Jul 11;7(1):5049 | 2017 |
| Huh SH, Warchol ME, Ornitz DM. Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling elife. 2015 Apt 27;4 | 2015 |
| Huh SH, Warchol ME, Ornitz DM, Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. eLife, 2015 Apr 27;4 | 2015 |
| Kim JY, Lee RH, Kim TM, Kim DW, Jeon YJ, Huh SH, OH SY, Kyba M, Kataoka H, Choi K, Ornitz DM, Chae Jl, Park C. OVOL2 is a critical regulator of ERTl in generating FLK+ cells, hematopoietic and endothelial cells from embryonic stem cells Blood. 2014 Nov 6;124(19):2948-52 | 2014 |
| Chen Z, Huang J, Liu Y, Dattilo LK, Huh SH, Ornitz D, Beebe DC. FGF signaling activates a Soxg-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands Development. 2014 Jul; 141 (1 3):2691 -701 | 2014 |
| Kim JY, Lee RH, Kim TM, Kim DW, Jeon YJ, Huh SH, Oh SY, Kyba M, Kataoka H, Choi K, Ornitz DM, Chae JI, Park C, OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells. Blood, 2014 Nov 6;124(19):2948-52 | 2014 |
| Chen Z, Huang J, Liu Y, Dattilo LK, Huh SH, Ornitz D, Beebe DC, FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Development (Cambridge, England), 2014 Jul;141(13):2691-701 | 2014 |
| Huh SH-, Nilrhi K., Lindfors PH, Haara O, Yang L, Ornitz DM--, Mikkola ML FGF20 governs formation of primary and secondary dermal condensations in developing hair follicles Genes Dev. 2013 Feb 15;27(4):450-8 | 2013 |
| Lin C, Yin I Bell SM, Veith GM, Chen H, Huh SH, Ornitz DM, Ma L Delineating a Conserved Genetic Cassette Promoting Outgrowth of Body Appendages PLoS Genet. 2013;9(1):e1003231 | 2013 |
| Huh SH, Närhi K, Lindfors PH, Häärä O, Yang L, Ornitz DM, Mikkola ML, Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes & development, 2013 Feb 15;27(4):450-8 | 2013 |
| Heile O, Harjunmaa E, Lindfors PH, Huh SH, Fliniaux l, Aberg T, Jernvall J, Ornitz DM, Mikkola ML, Thesleff l. Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling Development 201 2 Sep; 139( 1 7):31 89-99 | 2012 |
| Barak H, Huh SH., Chen S, Jeanpierre S, Martinovic J, Parisot M, Bole-Feysot C, Nitschke P, Salomon R, Antignac C, Ornitz DM, Kopan R. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man Dev Cell. 2012 Jun 12;22(6):1191-207 | 2012 |
| Huh SH, Jones J, Warchol ME, Ornitz DM. Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal PLoS Biol. 2012 Jan;10(1):e1001231 | 2012 |
| Häärä O, Harjunmaa E, Lindfors PH, Huh SH, Fliniaux I, Åberg T, Jernvall J, Ornitz DM, Mikkola ML, Thesleff I, Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling. Development (Cambridge, England), 2012 Sep;139(17):3189-99 | 2012 |
| Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschké P, Salomon R, Antignac C, Ornitz DM, Kopan R, FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Developmental cell, 2012 Jun 12;22(6):1191-207 | 2012 |
| Huh SH, Jones J, Warchol ME, Ornitz DM, Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS biology, 2012 Jan;10(1):e1001231 | 2012 |
| Huh SH and Ornitz DM. Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1 Development. 2010 Apr;137(7):1137-47 | 2010 |
| Huh SH, Ornitz DM, Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development (Cambridge, England), 2010 Apr;137(7):1137-47 | 2010 |
| Yin Y White AC, Huh SH, Hilton MJ, Kanazawa H, Long F, Ornitz DM An FGF-WNT gene regulatory network controls lung mesenchyme development Dev. Biol.2008 Jul 15;319(2):426-36 | 2008 |
| Yin Y, White AC, Huh SH, Hilton MJ, Kanazawa H, Long F, Ornitz DM, An FGF-WNT gene regulatory network controls lung mesenchyme development. Developmental biology, 2008 Jul 15;319(2):426-36 | 2008 |
| Park HS, Huh SH, Kim MS, Kim DY Gwag BJ, Cho SG, Choi EJ Neuronal nitric oxide synthase (nNOS) modulates the JNK1 activity through redox mechanism: a cGMP independent pathway Biochem Biophys Res Commun. 2006 Jul 28;346(2):408-14 | 2006 |
| Park HS, Huh SH, Kim MS, Kim DY, Gwag BJ, Cho SG, Choi EJ, Neuronal nitric oxide synthase (nNOS) modulates the JNK1 activity through redox mechanism: a cGMP independent pathway. Biochemical and biophysical research communications, 2006 Jul 28;346(2):408-14 | 2006 |
| Ryoo K, Huh SH, Lee YH, Yoon KW, Cho SG, Choi EJ Negative regulation of MEKKl-induced signaling by glutathione S-transferase Mu J. Blol. Chem.2004 Oct 15,279(42):43589-94 | 2004 |
| Patk HS, Yu JW, Cho JH, Kim MS, Huh SH, Ryoo K, Choi EJ lnhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism J. Biol. Chem.2004 Feb 27;27 9(9):7 584-90 | 2004 |
| Ryoo K, Huh SH, Lee YH, Yoon KW, Cho SG, Choi EJ, Negative regulation of MEKK1-induced signaling by glutathione S-transferase Mu. The Journal of biological chemistry, 2004 Oct 15;279(42):43589-94 | 2004 |
| Park HS, Yu JW, Cho JH, Kim MS, Huh SH, Ryoo K, Choi EJ, Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism. The Journal of biological chemistry, 2004 Feb 27;279(9):7584-90 | 2004 |
| Park HS, Cho SG, Kim CK, Hwang HS, Noh KT, Kim MS, Huh SH, Kim MJ, Ryoo K, Kim EK, Kang WJ, Lee JS, Seo JS, Ko YG, Kim S, Choi EJ. Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1 Mol Cell Biol. 2002 Nov;22(22):7721-30 | 2002 |
| Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation J. Biol. Chem. 2002 Jan 25;277 (4):257 3-8 | 2002 |
| Park HS, Cho SG, Kim CK, Hwang HS, Noh KT, Kim MS, Huh SH, Kim MJ, Ryoo K, Kim EK, Kang WJ, Lee JS, Seo JS, Ko YG, Kim S, Choi EJ, Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Molecular and cellular biology, 2002 Nov;22(22):7721-30 | 2002 |
| Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ, Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. The Journal of biological chemistry, 2002 Jan 25;277(4):2573-8 | 2002 |
| Kim JW Chang TS, Lee JE, Huh SH, Yeon SW, Yang WS, Joe CO, Mook-Jung l, Tanzi RE, Kim TW, Choi EJ. Negative regulation of the SAPI(JNK signaling pathway by presenilin 1 J. Cell. Biol.2001 Apr 30;1 53(3):457-63 | 2001 |
| Pa,k HS, Lee JS, Huh SH, Seo JS, Choi EJ Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase EMBO J. 2001 Feb 1;20(3):446-56 | 2001 |
| Kim JW, Chang TS, Lee JE, Huh SH, Yeon SW, Yang WS, Joe CO, Mook-Jung I, Tanzi RE, Kim TW, Choi EJ, Negative regulation of the SAPK/JNK signaling pathway by presenilin 1. The Journal of cell biology, 2001 Apr 30;153(3):457-63 | 2001 |
| Park HS, Lee JS, Huh SH, Seo JS, Choi EJ, Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. The EMBO journal, 2001 Feb 1;20(3):446-56 | 2001 |
| Park HS, Huh SH, Kim MS, Lee SH, Choi EJ. Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14382-7 | 2000 |
| Park HS, Huh SH, Kim Y Shim J, Lee SH, Park lS, Jung YK, Kim lY Choi EJ Selenite negatively regulates caspase-3 through a redox mechanism. J Biol Chem. 2000 Mar 24;275(12):8487-91 | 2000 |
| Park HS, Huh SH, Kim MS, Lee SH, Choi EJ, Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation. Proceedings of the National Academy of Sciences of the United States of America, 2000 Dec 19;97(26):14382-7 | 2000 |
| Park HS, Huh SH, Kim Y, Shim J, Lee SH, Park IS, Jung YK, Kim IY, Choi EJ, Selenite negatively regulates caspase-3 through a redox mechanism. The Journal of biological chemistry, 2000 Mar 24;275(12):8487-91 | 2000 |
| Willet SG, Thanintorn N, McNeill H, Huh SH, Ornitz DM, Huh WJ, Hoft SG, DiPaolo RJ, Mills JC, SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cellular and molecular gastroenterology and hepatology, 2023;16(3):325-339 | |
| Lin C, Yin Y, Bell SM, Veith GM, Chen H, Huh SH, Ornitz DM, Ma L, Delineating a conserved genetic cassette promoting outgrowth of body appendages. PLoS genetics, 2013;9(1):e1003231 | |
Review Article | |
| Ebeid M, Huh SH FGF signaling. diverse roles during cochlear development. BMB Rep. 2017 Oct;50(10):487-495. | 2017 |
Honors, Awards, and Recognition
| Society of Developmental Biology travel award | 2014 |
| Scholarship for workshop "The Mouse as an lnstrument for Ear Research V" | 2012 |
| Travel award for CSHL" Molecular Pathways in Organ Development & Disease" | 2012 |
| Fine Science & Merlie Traveling Fellowships | 2012 |
| Society of Developmental Biology travel award | 2011 |
| Society of Developmental Biology travel award | 2008 |
| Scholarship, Korea University | 1998 |
Professional Membership and Service
| American Society of Nephrology, Member | 2012 - Present |
| Association for Research in Otolaryngology | 2009 - Present |
| Society of Developmental Biology, Member | 2008 - Present |
Other Service
| Mentored MSTP Student, mentor | 07/2012 - 08/2016 |
| Mentor undergraduate student | 2010 - 01/2012 |
| Teacher Assistant, Teacher Assistant Cell biology | 2004 - 12/2011 |
| Teacher Assistant Advanced Biochemistry, Teacher Assistant | 07/2000 - 12/2004 |
Teaching Experience
| Medicine, Course, Assistant Professor | Annual 2023 |
| University of Nebraska Medical Center, Course, Assistant Professor | Annual 2016 - 2022 |
| Washington University, Small Group, Research Instructor | Annual 2012 - 2015 |
| Ting Therapeutics, Course, Senior Scientist | Annual 07.22 - 2022 |
Directed Student Learning
| Supervised Research, Advised: Hunter Hammett | 2025 - 2025 |
| Supervised Research, Advised: Braden Lewis | 2025 - 2025 |
| Doctoral Advisory Committee Chair, Advised: Pooja Roy | 2020 - 2022 |
| Doctoral Advisory Committee Chair, Advised: Yuetong Zhao | 2019 - 2019 |
| Doctoral Advisory Committee Chair, Advised: Brennan Roche | 2017 - 2021 |
| Supervised Research, Advised: Anna Slezak | 2017 - 2017 |
| Supervised Research, Advised: Emily Supe | 2017 - 2017 |
| Doctoral Advisory Committee Member, Advised: Amanda Smith | 2016 - 2019 |
Fellows supervised
| Research Advisor, 0 fellows supervised | 04/2021 - 06/2022 |
| Post-Doc Advisor, 0 fellows supervised | 09/2017 - 06/2018 |
| Research Advisor, 0 fellows supervised | 08/2016 - 08/2019 |