Sung-Ho Huh
Assistant Professor
Department:
SOM-Otolaryngology - Head and Neck Surgery
Email:
shuh@umc.edu
Work Phone:
(601) 984-5162
Education
| Washington University in St. Louis, Department of Developmental Biology | 2012 |
| Washington University in St. Louis, PhD, Molecular Cell Biology program in DBBS | 2009 |
| Korea University, Seoul, Korea, Researcher in Cell Death Research Center | 2002 |
| Korea University Seoul, Korea., MS, Graduate School of Biotechnology | 2001 |
| Korea University Seoul, Korea., BS, Genetic Engineering | 1999 |
Current Positions
| Assistant Professor, School of Medicine | 2023 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Ting Therapeutics, School of Medicine | 07/2022 - 12/2022 |
| Assistant Professor, University of Nebraska Medical Center, School of Medicine | 2016 - 06/2022 |
| Instructor, Washington University, School of Medicine | 11/2012 - 12/2015 |
Sponsored Program Funding
| Extramural, Child Health Research lnstitute Grant | 01/2021 - 12/2022 |
| Extramural, DHHS Nebraska State | 07/2018 - 06/2019 |
| Extramural, Pilot Grant, UAB The Hepato/Ranal Fibrocystic Disease Core Center | 07/2018 - 06/2020 |
| Extramural, Edna lttner Pediatric Research Grant | 11/2016 - 10/2017 |
| Extramural, CoBRE Pilot Award | 09/2016 - 08/2018 |
| Extramural, K99/R00 NIH Pathway to lndependence | 07/2013 - 12/2019 |
| Extramural, Hearing Health Foundation Research Grant renewal | 07/2011 - 06/2013 |
Publications
Journal Article | |
| Huh SH-, Nilrhi K., Lindfors PH, Haara O, Yang L, Ornitz DM--, Mikkola ML FGF20 governs formation of primary and secondary dermal condensations in developing hair follicles, Genes&Development 2O13 Feb; 27 . 450458 *Equal contribution, '*Correspondence. Evaluated by Faculty of '1000. | 2013 |
| Barak H-, Huh SH., Chen S, Jeanpierre S, Martinovic J, Parisot M, Bole-Feysot C, Nitschke P, Salomon R, Antignac C, Ornitz DM**, Kopan R*. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man, Dev Cell.2012 Jun 22(6):1191-1207 "Equal contribution, "*Correspondence. Previewed in 'Dev.Cell.' Featured in Cover Page. Evaluated by Faculty of 1000. | 2012 |
| Huh SH, Jones J, Warchol ME, Ornitz DM. Difierentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal, PLoS Biology'10(1): e1001231. Highlighted in 'Nature' . Evaluated by Faculty of 1 000. | |
| Xue W, Kong Y Abu R, Roy P, Huh SH, Kuss M, Kumar V, Duan B. Regulation of Schwann Cell and DRG Neurite Behaviors within Decellularized Peripheral Nerve Matrix. ACS Appl Materlnterfaces. 2022 F eb 23;14(7):8693-8704. doi: 10.1021 lacsami. 1 c20320. | 2022 |
| Li H, Kurtzeborn K, Kupari J, Gui Y Siefker E, Lu B, Mdtlik K, Olfat S, Montano-Rodriguez AR, Huh SH, Costantini F, Andressoo JO, Kuure S. Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development.2021 May 1 5 ; 1 a8( 1 0). doi: 1 0. 1 2421 dev. 1 97 47 5. | 2021 |
| Ebeid M, Huh SH. Mesenchymal ETV transcription factors regulate cochlear length.Hear Res. 2020 Aug 20;396;1 08039. doi: 1 0. 1 01 6/j.heares.2020. 1 08039. | 2020 |
| Huh SH., Ha L, Jang HS Nephron Progenitor Maintenance ls Controlled through Fibroblast Growth Factors and Sproutyl lnteraction. J Am Soc Nephrol 2020 Aug 4;ASN.2020040401 . doi: 10.1681/ASN.2020040401. 'Correspondence | 2020 |
| Jansson L, Ebeid M, Shen JW, Mokhtari TE, Quiruz LA, Ornitz DM, Huh SH., Cheng AG.. p-Catenin is required for radial cell patterning and identity in the developing mouse cochlea.Proc NatlAcad Sci U S A. 2019 Oct 1 5;116(42):21054-21 060. doi: 1 0. 1 073/pnas. 1 910223116. *Correspondence | 2019 |
| Yang LM, Cheah KSE, Huh SH*, OrniE DM.. Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner PLoS Genet. 2019 Jul;15(7):e 1008254. doi: '1 0.1 371 /journal.pgen.l 008254. | 2019 |
| Yang LM, Huh SH, Ornitz DM. FcF2o-Expressing, WnlResponsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area. Dev Cell 2018 Sep 10;46(5):564-580.e5. doi: 1 0.1016/j devcel.2O1 8.07.01 0. | 2018 |
| Elo T, Lindfors PH, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Orni2 DM, Poutanen M, Howard BA, Mikkola ML. Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty, Sci Rep.2017Jul 1 I ;7(1):5049. doi: 10.1038/s41 598-017-04637-1 | 2017 |
| Huh SH*, Warchol ME, Ornitz DM*. Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling, elife. 2015 Apt 27;4. doi: '10.7554/elife.05921 | 2015 |
| Kim JY, Lee RH, Kim TM, Kim DW, Jeon YJ, Huh SH, OH SY, Kyba M, Kataoka H, Choi K, Ornitz DM, Chae Jl, Park C. OVOL2 is a critical regulator of ERTl in generating FLK+ cells, hematopoietic and endothelial cells from embryonic stem cells, Blood. 2014 Nov 6;124(19):2948-52. | 2014 |
| Chen Z, Huang J, Liu Y, Dattilo LK, Huh SH, Ornitz D, Beebe DC. FGF signaling activates a Soxg-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands, Development. 2014 Jul; 141 (1 3):2691 -701. | 2014 |
| Heile O, Harjunmaa E, Lindfors PH, Huh SH, Fliniaux l, Aberg T, Jernvall J, Ornitz DM, Mikkola ML, Thesleff l. Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling, Development 201 2 Sep;'1 39( 1 7):31 89-99. | 2012 |
| Huh SH and Ornitz DM. p-catenin deficiency causes DiGeorge syndrome- like phenotypes through. regulation of Tbx1, Development 2010 Apr;137(7).1137 47. | 2010 |
| Yin Y White AC, Huh SH, Hilton MJ, Kanazawa H, Long F, Ornitz DM An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev. Biol.2008 Jul 15;319(2):426-36. | 2008 |
| Park HS, Huh SH, Kim MS, Kim DY Gwag BJ, Cho SG, Choi EJ Neuronal nitric oxide synthase (nNOS) modulates the JNK1 activity through redox mechanism: a cGMP independent pathway. Biochem. Biophys. Re s. Com m u n. 2006 Jul 28;346(2).408-1 4. | 2006 |
| Ryoo K, Huh SH, Lee YH, Yoon KW, Cho SG, Choi EJ Negative regulation of MEKKl-induced signaling by glutathione S-transferase Mu. J. Blol. Chem.2004 Ocl 15,279(42):43589-94. | 2004 |
| Patk HS, Yu JW, Cho JH, Kim MS, Huh SH, Ryoo K, Choi EJ lnhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism. J. Biol. Chem.2004 Feb 27;27 9(9):7 584-90 | 2004 |
| Park HS, Cho SG, Kim CK, Hwang HS, Noh KT, Kim MS, Huh SH, Kim MJ, Ryoo K, Kim EK, Kang WJ, Lee JS, Seo JS, Ko YG, Kim S, Choi EJ. Heat shock protein hsp72 is a negative regulator of apoptosis signa l-regu lating ki nase 1 . M ol. C e I l. B i ol. 2002 Nov ;22(22):7 7 21 -30. | 2002 |
| Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. J. Biol. Chem. 2002 Jan 25;277 (4):257 3-8. | 2002 |
| Kim JW Chang TS, Lee JE, Huh SH, Yeon SW, Yang WS, Joe CO, Mook-Jung l, Tanzi RE, Kim TW, Choi EJ. Negative regulation of the SAPI(JNK signaling pathway by presenilin 1. J. Cell. Biol.2001 Apr 30;1 53(3):457-63. | 2001 |
| Pa,k HS, Lee JS, Huh SH, Seo JS, Choi EJ Hsp72 functions as a natural inhibitory protein of c-Jun Nterminal kinase. EMBO J. 2001 Feb 1;20(3):446-56. | 2001 |
| Park HS, Huh SH, Kim MS, Lee SH, Choi EJ. Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation. Proc. Natl. Acad. Sci. USA 2000 Dec 19;97(26):14382-7 . | 2000 |
| Park HS, Huh SH, Kim Y Shim J, Lee SH, Park lS, Jung YK, Kim lY Choi EJ Selenite negatively regulates caspase-3 through a redox mechanism. J. Biol. Chem.2000 Mar 24;275(12):8487-91. Reviews 'l | 2000 |
| Lin C, Yin I Bell SM, Veith GM, Chen H, Huh SH, Ornitz DM, Ma L Delineating a Conserved Genetic Cassette Promoting Outgrowth of Body Appendages. PLoS Genef. 9(1). e1 003231 | |
Review Article | |
| Ebeid M, Huh SH FGF signaling. diverse roles during cochlear development. BMB Rep. 2017 Oct;50(10):487-495. | 2017 |
Honors, Awards, and Recognition
| Scholarship in Lions Club | 2017 |
| Society of Developmental Biology travel award | 2014 |
| Scholarship for workshop "The Mouse as an lnstrument for Ear Research V" | 2012 |
| Travel award for CSHL" Molecular Pathways in Organ Development & Disease" | 2012 |
| Fine Science & Merlie Traveling Fellowships | 2012 |
| Society of Developmental Biology travel award | 2011 |
| Society of Developmental Biology travel award | 2008 |
| Scholarship, Korea University | 1998 |
Other Service
| Mentored MSTP Student, mentor | 07/2012 - 08/2016 |
| Mentor undergraduate student | 2010 - 01/2012 |
| Teacher Assistant, Teacher Assistant Cell biology | 2004 - 12/2011 |
| Teacher Assistant Advanced Biochemistry, Teacher Assistant | 07/2000 - 12/2004 |
Teaching Experience
| Medicine, Course, Assistant Professor | Annual 2023 |
| University of Nebraska Medical Center, Course, Assistant Professor | Annual 2016 - 2022 |
| Washington University, Small Group, Research Instructor | Annual 2012 - 2015 |
| Ting Therapeutics, Course, Senior Scientist | Annual 07.22 - 2022 |