Michael D. Hebert, PhD

Michael D. Hebert, PhD

Professor

Department:
SOM-Cell and Molecular Biology

Email:
mhebert@umc.edu

Work Phone:
(601) 984-1526

Education

Georgia State University, PhD, Biology/Molecular Genetics1997
Kennesaw State University, BS, Biology/Cytogenetics1990

Current Positions

Associate Member, School of Medicine, Department of Cancer Institute2012 - Present
Professor, School of Medicine, Department of Biochemistry07/2010 - Present
Assistant Professor, School of Medicine, Department of Neurology04/2003 - Present
Assistant Professor, School of Medicine, Department of Neurology2003 - Present
Member of Graduate Faculty, School of2002 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Biochemistry07/2007 - 06/2010
Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Biochemistry08/2002 - 07/2007
Post-doctoral fellow, Case Western Reserve University, School of , Department of Genetics1998 - 2002
Post-doctoral fellow, Emory University, School of , Department of Pathology1997 - 1998
Cytogenetic Specialist (Nationally Certified), Emory University, School of , Department of Population and Molecular Cytogenetics Laboratory1990 - 1992

Sponsored Program Funding

Intramural, Regulation of nuclear SMN activity by coilin, UMMC11/2013 - 10/2014
Extramural, Administrative Supplement, National Institutes of Health08/2009 - 07/2011
Extramural, Nuclear bodies and ribonucleoprotein biogenesis, National Institutes of Health04/2008 - 01/2013
Extramural, Disrupted pre-mRNA splicing in Machado-Joseph disease, National Ataxia Foundation01/2008 - 12/2008
Extramural, Nuclear inclusions and neuronal death, Carraway Foundation08/2007 - 08/2008
Extramural, Rational selection of Friedreich’s ataxia therapeutics, Muscular Dystrophy Association01/2007 - 12/2008
Extramural, PolyQ proteins and pre-mRNA splicing, National Ataxia Foundation01/2006 - 12/2006
Extramural, An in vivo reporter system for measuring the transcription of sticky DNA found in Friedreich’s ataxia, Friedreich’s Ataxia Research Alliance04/2005 - 03/2006
Intramural, Disrupted Nuclear Organization and Function in Machado-Joseph disease, University of Mississippi Medical Center11/2003 - 10/2004
Extramural, Regulation of coilin and SMN interaction by coilin associated proteins, Muscular Dystrophy Association, Research Grant07/2003 - 06/2006
Extramural, Regulation of coilin and SMN interaction by coilin associated proteins, Muscular Dystrophy Association, Research Development Grant01/2002 - 01/2003

Publications

News

Matera AG, Hebert MD, The survival motor neurons protein uses its ZPR for nuclear localization. Nature cell biology, 2001 Apr;3(4):E93-52001

Journal Article

Enwerem II, Wu G, Yu YT, Hebert MD. Cajal Body Proteins Differentially Affect the Processing of Box C/D scaRNPs. PLoS One. 2015 Apr 13;10(4):e0122348. doi: 10.1371/journal.pone.0122348. eCollection 2015.2015
Yujing Li, Ka-wing Fong, Mengfan Tang, Xin Han, Zihua Gong, Wenbin Ma, Michael Hebert, Zhou Songyang, and Junjie Chen Fam118B, a novel component in Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability J Cell Sci jcs.143453; Advance Online Article February 25, 2014, doi:10.1242/jcs.1434532014
Hearst SM, Gilder AS, Negi SS, Davis MD, George EM, Whittom AA, Toyota CG, Husedzinovic A, Gruss OJ, Hebert MD Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines J Cell Sci. 2009 Jun 1;122:1872-81. Epub 2009 May 12. PMID: 194358042009
Whittom AA, Xu H, Hebert MD. Coilin levels and modifications influence artificial reporter splicing.Coilin levels and modifications influence artificial reporter splicing. Cell Mol Life Sci. 2008 Apr;65(7-8):1256-71.2008
Sun J, Xu H, Negi S, Subramony SH, Hebert MD. Differential effects of polyglutamine proteins on nuclear organization and artificial reporter splicing. J Neurosci Res. 2007 Aug 15;85(11):2306-172007
Vig PJ, Wei J, Shao Q, Hebert MD, Subramony SH, Sutton LT. Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1. Neurosci Lett. 2007 Jun 8;420(1):53-72007
D'Souza DR, Wei J, Shao Q, Hebert MD, Subramony SH, Vig PJ. Tissue transglutaminase crosslinks ataxin-1: possible role in SCA1 pathogenesis. Neurosci Lett. 2006 Nov 27;409(1):5-9.2006
Grant L, Sun J, Xu H, Subramony SH, Chaires JB, Hebert MD. Rational selection of small molecules that increase transcription through the GAA repeats found in Friedreich's ataxia. FEBS Lett. 2006 Oct 2;580(22):5399-4052006
Sun J, Xu H, Subramony SH, Hebert MD. Interactions between coilin and PIASy partially link Cajal bodies to PML bodies. J Cell Sci. 2005 Nov 1;118(Pt 21):4995-50032005
Hongzhi Xu, Ramesh S. Pillai, Teldja N. Azzouz, Karl B. Shpargel, Christian Kambach, Michael D. Hebert, Daniel Schümperli, A. Gregory Matera The C-terminal domain of coilin interacts with Sm proteins and U snRNPs Chromosoma 2005 Aug; 114(3):155-662005
Hongzhi Xu, Z. Brad Somers, Melvin L. Robinson II and Michael D. Hebert Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis BMC Cell Biol 2005 Jul 11; 6(1):292005
Xu H, Hebert MD A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin BMC Cell Biol 2005 Apr 29;6(1):232005
Dundr M, Hebert MD, Karpova TS, Stanek D, Xu H, Shpargel KB, Meier UT, Neugebauer KM, Matera AG, Misteli T In vivo kinetics of Cajal body components J. Cell Biol. 2004 Mar 15, 164:831-842.2004
Karl B. Shpargel, Jason K. Ospina, Karen E. Tucker, A. Gregory Matera and Michael D. Hebert Control of Cajal body number is mediated by the coilin C-terminus J Cell Sci. 2003 Jan 15; 116(Pt2):303-312.2003
Hebert M.D., Shpargel K.B., Ospina J.K., Tucker K.E. and Matera A.G Coilin methylation regulates nuclear body formation Developmental Cell. 2002 Sept 3: 329-3372002
Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta Hum Mol Genet. 2002 Jul 15;11(15):1785-95.2002
Hebert MD, Szymczyk PW, Shpargel KB, Matera AG Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein Genes Dev. 2001 Oct 15;15(20):2720-92001
Matera AG, Hebert MD The survival motor neurons protein uses its ZPR for nuclear localization Nat Cell Biol. 2001 Apr;3(4):E93-52001
Hebert MD, Matera AG Self-association of coilin reveals a common theme in nuclear body localization Mol Biol Cell. 2000 Dec;11(12):4159-712000
Liu J, Hebert MD, Ye Y, Templeton DJ, Kung H, Matera AG Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies J Cell Sci. 2000 May;113 ( Pt 9):1543-522000
Tucker KE, Massello LK, Gao L, Barber TJ, Hebert MD, Chan EK, Matera AG Structure and characterization of the murine p80 coilin gene, Coil J Struct Biol. 2000 Apr;129(2-3):269-772000
Curtis SK, Hebert MD, Saha BK Carriers of X-linked agammaglobulinemia (XLA) due to germline mutation in the Btk gene Am J Med Genet. 2000 Jan 31;90(3):229-32.2000
Hebert MD, Houghton JE Regulation of ornithine utilization in Pseudomonas aeruginosa (PAO1) is mediated by a transcriptional regulator, OruR J Bacteriol. 1997 Dec;179(24):7834-42.1997
Logan MK, Lett KE, McLaurin DM, Hebert MD, Coilin as a regulator of NF-kB mediated inflammation in preeclampsia. Biology open, 2022 Jul 15;11(7)2022
Lett KE, Logan MK, McLaurin DM, Hebert MD, Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis. Molecular biology of the cell, 2021 Oct 1;32(20):br42021
Logan MK, Lett KE, Hebert MD, The Cajal body protein coilin is a regulator of the miR-210 hypoxamiR and influences MIR210HG alternative splicing. Journal of cell science, 2021 Jun 15;134(12)2021
Monroe JD, Moolani SA, Irihamye EN, Lett KE, Hebert MD, Gibert Y, Smith ME, Cisplatin and phenanthriplatin modulate long-noncoding RNA expression in A549 and IMR90 cells revealing regulation of microRNAs, Wnt/β-catenin and TGF-β signaling. Scientific reports, 2021 May 17;11(1):104082021
Logan MK, McLaurin DM, Hebert MD, Synergistic interactions between Cajal bodies and the miRNA processing machinery. Molecular biology of the cell, 2020 Jul 15;31(15):1561-15692020
McLaurin DM, Logan MK, Lett KE, Hebert MD, Molecular determinants that govern scaRNA processing by Drosha/DGCR8. Biology open, 2020 Oct 26;9(10)2020
Burke MF, McLaurin DM, Logan MK, Hebert MD, Alteration of 28S rRNA 2'-O-methylation by etoposide correlates with decreased SMN phosphorylation and reduced Drosha levels. Biology open, 2019 Mar 27;8(3)2019
Logan MK, Burke MF, Hebert MD, Altered dynamics of scaRNA2 and scaRNA9 in response to stress correlates with disrupted nuclear organization. Biology open, 2018 Sep 27;7(9)2018
Burke MF, Logan MK, Hebert MD, Identification of additional regulatory RNPs that impact rRNA and U6 snRNA methylation. Biology open, 2018 Aug 10;7(8)2018
Hebert MD, Poole AR, Towards an understanding of regulating Cajal body activity by protein modification. RNA biology, 2017 Jun 3;14(6):761-7782017
Poole AR, Vicino I, Adachi H, Yu YT, Hebert MD, Regulatory RNPs: a novel class of ribonucleoproteins that potentially contribute to ribosome heterogeneity. Biology open, 2017 Sep 15;6(9):1342-13542017
Poole AR, Enwerem II, Vicino IA, Coole JB, Smith SV, Hebert MD, Identification of processing elements and interactors implicate SMN, coilin and the pseudogene-encoded coilp1 in telomerase and box C/D scaRNP biogenesis. RNA biology, 2016 Oct 2;13(10):955-9722016
Poole AR, Hebert MD, SMN and coilin negatively regulate dyskerin association with telomerase RNA. Biology open, 2016 Jun 15;5(6):726-352016
Li Y, Fong KW, Tang M, Han X, Gong Z, Ma W, Hebert M, Songyang Z, Chen J, Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. Journal of cell science, 2014 May 1;127(Pt 9):2029-392014
Enwerem II, Velma V, Broome HJ, Kuna M, Begum RA, Hebert MD, Coilin association with Box C/D scaRNA suggests a direct role for the Cajal body marker protein in scaRNP biogenesis. Biology open, 2014 Apr 15;3(4):240-92014
Broome HJ, Hebert MD, Coilin displays differential affinity for specific RNAs in vivo and is linked to telomerase RNA biogenesis. Journal of molecular biology, 2013 Feb 22;425(4):713-242013
Hebert MD, Signals controlling Cajal body assembly and function. The international journal of biochemistry & cell biology, 2013 Jul;45(7):1314-72013
Broome HJ, Carrero ZI, Douglas HE, Hebert MD, Phosphorylation regulates coilin activity and RNA association. Biology open, 2013 Apr 15;2(4):407-152013
Velma V, Broome HJ, Hebert MD, Regulated specific proteolysis of the Cajal body marker protein coilin. Chromosoma, 2012 Dec;121(6):629-422012
Velma V, Carrero ZI, Allen CB, Hebert MD, Coilin levels modulate cell cycle progression and γH2AX levels in etoposide treated U2OS cells. FEBS letters, 2012 Sep 21;586(19):3404-92012
Gilder AS, Do PM, Carrero ZI, Cosman AM, Broome HJ, Velma V, Martinez LA, Hebert MD, Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage. Molecular biology of the cell, 2011 Apr;22(7):1070-92011
Velma V, Carrero ZI, Cosman AM, Hebert MD, Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining. FEBS letters, 2010 Dec 1;584(23):4735-92010
Bidwell GL 3rd, Whittom AA, Thomas E, Lyons D, Hebert MD, Raucher D, A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation. Peptides, 2010 May;31(5):834-412010
Hebert MD, Phosphorylation and the Cajal body: modification in search of function. Archives of biochemistry and biophysics, 2010 Apr 15;496(2):69-762010
Toyota CG, Davis MD, Cosman AM, Hebert MD, Coilin phosphorylation mediates interaction with SMN and SmB'. Chromosoma, 2010 Apr;119(2):205-152010
Hearst SM, Gilder AS, Negi SS, Davis MD, George EM, Whittom AA, Toyota CG, Husedzinovic A, Gruss OJ, Hebert MD, Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines. Journal of cell science, 2009 Jun 1;122(Pt 11):1872-812009
Whittom AA, Xu H, Hebert MD, Coilin levels and modifications influence artificial reporter splicing. Cellular and molecular life sciences : CMLS, 2008 Apr;65(7-8):1256-712008
Hebert MD, Targeting the gene in Friedreich ataxia. Biochimie, 2008 Aug;90(8):1131-92008
Hebert MD, Whittom AA, Gene-based approaches toward Friedreich ataxia therapeutics. Cellular and molecular life sciences : CMLS, 2007 Dec;64(23):3034-432007
Sun J, Xu H, Negi S, Subramony SH, Hebert MD, Differential effects of polyglutamine proteins on nuclear organization and artificial reporter splicing. Journal of neuroscience research, 2007 Aug 15;85(11):2306-172007
Vig PJ, Wei J, Shao Q, Hebert MD, Subramony SH, Sutton LT, Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1. Neuroscience letters, 2007 Jun 8;420(1):53-72007
D'Souza DR, Wei J, Shao Q, Hebert MD, Subramony SH, Vig PJ, Tissue transglutaminase crosslinks ataxin-1: possible role in SCA1 pathogenesis. Neuroscience letters, 2006 Nov 27;409(1):5-92006
Grant L, Sun J, Xu H, Subramony SH, Chaires JB, Hebert MD, Rational selection of small molecules that increase transcription through the GAA repeats found in Friedreich's ataxia. FEBS letters, 2006 Oct 2;580(22):5399-4052006
Sun J, Xu H, Subramony SH, Hebert MD, Interactions between coilin and PIASy partially link Cajal bodies to PML bodies. Journal of cell science, 2005 Nov 1;118(Pt 21):4995-50032005
Xu H, Somers ZB, Robinson ML 2nd, Hebert MD, Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis. BMC cell biology, 2005 Jul 11;6(1):292005
Xu H, Pillai RS, Azzouz TN, Shpargel KB, Kambach C, Hebert MD, Schümperli D, Matera AG, The C-terminal domain of coilin interacts with Sm proteins and U snRNPs. Chromosoma, 2005 Aug;114(3):155-662005
Xu H, Hebert MD, A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. BMC cell biology, 2005 Apr 29;6(1):232005
Dundr M, Hebert MD, Karpova TS, Stanek D, Xu H, Shpargel KB, Meier UT, Neugebauer KM, Matera AG, Misteli T, In vivo kinetics of Cajal body components. The Journal of cell biology, 2004 Mar 15;164(6):831-422004
Shpargel KB, Ospina JK, Tucker KE, Matera AG, Hebert MD, Control of Cajal body number is mediated by the coilin C-terminus. Journal of cell science, 2003 Jan 15;116(Pt 2):303-122003
Hebert MD, Shpargel KB, Ospina JK, Tucker KE, Matera AG, Coilin methylation regulates nuclear body formation. Developmental cell, 2002 Sep;3(3):329-372002
Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG, SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. Human molecular genetics, 2002 Jul 15;11(15):1785-952002
Hebert MD, Szymczyk PW, Shpargel KB, Matera AG, Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein. Genes & development, 2001 Oct 15;15(20):2720-92001
Hebert MD, Matera AG, Self-association of coilin reveals a common theme in nuclear body localization. Molecular biology of the cell, 2000 Dec;11(12):4159-712000
Tucker KE, Massello LK, Gao L, Barber TJ, Hebert MD, Chan EK, Matera AG, Structure and characterization of the murine p80 coilin gene, Coil. Journal of structural biology, 2000 Apr;129(2-3):269-772000
Liu J, Hebert MD, Ye Y, Templeton DJ, Kung H, Matera AG, Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies. Journal of cell science, 2000 May;113 ( Pt 9):1543-522000
Curtis SK, Hebert MD, Saha BK, Twin carriers of X-linked agammaglobulinemia (XLA) due to germline mutation in the Btk gene. American journal of medical genetics, 2000 Jan 31;90(3):229-322000
Hebert MD, Houghton JE, Regulation of ornithine utilization in Pseudomonas aeruginosa (PAO1) is mediated by a transcriptional regulator, OruR. Journal of bacteriology, 1997 Dec;179(24):7834-421997
Förthmann B, van Bergeijk J, Lee YW, Lübben V, Schill Y, Brinkmann H, Ratzka A, Stachowiak MK, Hebert M, Grothe C, Claus P, Regulation of neuronal differentiation by proteins associated with nuclear bodies. PloS one, 2013;8(12):e82871
Enwerem II, Wu G, Yu YT, Hebert MD, Cajal body proteins differentially affect the processing of box C/D scaRNPs. PloS one, 2015;10(4):e0122348
Broome HJ, Hebert MD, In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing. PloS one, 2012;7(4):e36300
Carrero ZI, Velma V, Douglas HE, Hebert MD, Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product. PloS one, 2011;6(10):e25743

Review Article

Hebert MD Phosphorylation and the Cajal body: modification in search of function Arch Biochem Biophys. 2010 Apr 15;496(2):69-76. Epub 2010 Mar 1. Review. PMID: 201936562010
Hebert MD. Targeting the gene in Friedreich ataxia. Biochimie. 2008 Aug;90(8):1131-9.2008
Hebert MD, Whittom AA. Gene-based approaches toward Friedreich ataxia therapeutics. Cell Mol Life Sci. 2007 Dec;64(23):3034-432007

Abstracts

Hanna J. Broome and Michael D. Hebert Coilin implicated in U snRNA 3’ end processing: nucleic acid interaction studies point to additional functions of the Cajal body marker protein2011
Venkatramreddy Velma, Zunamys Carrero, Carmen Allen and Michael D. Hebert Coilin levels modulate cell cycle progression and gamma H2AX levels in etoposide treated U2OS cells2011
Andrew Gilder, Zunamys Carrero, Michelle Cosman, Venkatramreddy Velma, Luis Martinez and Michael Hebert DNA damage induced apoptosis requires coilin. Presented at the Subnuclear Structures and Disease meeting2010
Andrew Gilder, Cory Toyota, Misty Davis, Michelle Cosman and Michael Hebert Coilin phosphorylation modulates its interaction with SmB and SMN2009
Angela A. Whittom, Sana Bhatti, Patricia A. Ragazzon, S.H. Subramony, David W. Boykin, Jonathan B. Chaires and Michael D. Hebert Aromatic amidines increase transcription through GAA repeats found in Friedreich ataxia2008
LaKechia Grant, June Sun, HonghzhiXu, S.H. Subramony, Jonathan B. Chaires and Michael D. Hebert Rational selection of Friedreich’s ataxia therapeutics2006
June Sun, H. Xu, S.H. Subramony and Michael Hebert Ataxin-3 Polyglutamine Mutant Reduces m-RNA Splicing Efficiency2005
H. Xu, M. D. Hebert Knockout of Cajal Body Marker Protein Coilin Results in Decreased Transcription Efficiency2005
June Sun, Hongzhi Xu, S.H. Subramony and Michael D. Hebert Disrupted Nuclear Organization in Machado-Joseph Disease2005
Michael D. Hebert, Hongzhi Xu and A. Gregory Matera CAP36C, a Novel Coilin Associated Protein Involved in snRNP Biogenesis2003
Kyla M. Lewis, Hongzhi Xu, Eric M. George, S. H. Subramony and Michael D. Hebert Disrupted Nuclear Organization and Function in Machado-Joseph disease2003

Book Chapter

Michael D. Hebert and Andrew S. Gilder. The relationship of the Cajal body to the nucleolus "The Nucleolus”, Mark Olson, Ed.2011
Michael D. Hebert and Andrew S. Gilder The relationship of the Cajal body to the nucleolus Chapter in the book “The Nucleolus”, Mark Olson, Ed. 20112011

Presentations

State/Local Invited Seminars/Lectures, The Cajal body and microRNA biogenesis10/2020
Invited Symposia, Ribosome specialization in health and disease, UMMC Cell and Mol Biol10/2018
State/Local Invited Seminars/Lectures, Research in the Department of Cell and Molecular Biology at UMMC, Alcorn University09/2018
State/Local Invited Seminars/Lectures, Coilin: Not just the Cajal body marker protein., Kennesaw State University02/2013
State/Local Invited Seminars/Lectures, “Coilin: Not just the Cajal body marker protein.”, Department of Biochemistry, for the departmental annual retreat., UMMC09/2012
Meeting Abstract, Coilin implicated in U snRNA 3’ end processing: nucleic acid interaction studies point to additional functions of the Cajal body marker protein. Hanna J. Broome and Michael D. Hebert, ASCB General meeting, Denver, Colorado12/2011
Meetinig Abstract, Coilin levels modulate cell cycle progression and gamma H2AX levels in etoposide treated U2OS cells. Venkatramreddy Velma, Zunamys Carrero, Carmen Allen and Michael D. Hebert, ASCB General meeting, Denver, Colorado12/2011
State/Local Invited Seminars/Lectures, The Cajal body: What have we learned in the last 108 years?, Department of Chemistry and Biochemistry, Millsaps College09/2011
State/Local Invited Seminars/Lectures, The Cajal body: What have we learned in the last 108 years?, Department of Pharmacology and Toxicology, University of Mississippi Medical Center09/2011
State/Local Invited Seminars/Lectures, The Science of Employee Management: Creating a More Productive Laboratory Environment, UMMC Basic Science Faculty, In partnership with the UMMC Office of Research and Human Resources., University of Mississippi Medical Center09/2011
State/Local Invited Seminars/Lectures, “The Cajal body: What have we learned in the last 108 years?”, Department of Chemistry and Biochemistry, Millsaps College09/2011
State/Local Invited Seminars/Lectures, “The Cajal body: What have we learned in the last 108 years?”, Department of Pharmacology and Toxicology, UMMC09/2011
State/Local Invited Seminars/Lectures, “The Science of Employee Management: Creating a More Productive Laboratory Environment”, UMMC Basic Science Faculty, In partnership with the UMMC Office of Research and Human Resources., UMMC09/2011
State/Local Invited Seminars/Lectures, The Cajal body: What have we learned in the last 108 years?, Department of Biochemistry, University of Mississippi Medical Center04/2011
National and International Invited Seminars/Lectures, DNA damage induced apoptosis requires coilin, Presented at the Subnuclear Structures and Disease meeting, The Wellcome Trust Conference Center. Cambridge, UK07/2010
State/Local Invited Seminars/Lectures, Coilin, Cajal bodies and Cancer, Cancer Institute, Works in Progress seminar series, The University of Mississippi Medical Center05/2010
State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Depatment of Pharmacology, Ole Miss10/2008
State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Chemstry and Biochemsitry, University of Southern Mississippi10/2008
State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Physiology, University of Mississippi Medical Center03/2008
Invited Symposia, Making a Subnuclear Domain, Department of Biochemistry, University of Mississippi Medical Center05/2007
National and International Invited Seminars/Lectures, Rational selection of Friedreich’s ataxia therapeutics, Third International Friedreich’s Ataxia Scientific Conference, National Institutes of Health, Bethesda, Maryland11/2006
State/Local Invited Seminars/Lectures, Ataxias and Disrupted Nuclear Efficiency, Center for Investigating Neurodegenerative Disease, University of Mississippi Medical Center09/2006
State/Local Invited Seminars/Lectures, Establishing a Neurodegenerative Disease Center of Excellence, Multidisciplinary Research Meeting, Department of Anesthesiology, University of Mississippi Medical Center04/2006
State/Local Invited Seminars/Lectures, Friedreich’s ataxia small molecule screening, Neurodegenerative Disease Research Interest Group, University of Mississippi Medical Center02/2006
State/Local Invited Seminars/Lectures, Inclusive inclusions? Neurodegenerative disease and nuclear cell biology, Department of Biochemistry, University of Mississippi Medical Center04/2005
State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Biological Sciences, Mississippi State University09/2004
Regional Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center-Shreveport09/2004
State/Local Invited Seminars/Lectures, Everything you always wanted to know about snRNPs (but were afraid to ask), Department of Biochemistry, University of Mississippi Medical Center04/2004
State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Pharmacology and Toxicology, University of Mississippi Medical Center04/2004
State/Local Invited Seminars/Lectures, Genomics to Biology, 68th Annual Meeting of the Mississippi Academy of Sciences, Biloxi, Mississippi02/2004
State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Biochemistry, Mississippi State University10/2003
State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Chemistry, Jackson State University07/2003
State/Local Invited Seminars/Lectures, Coilin, Cajal bodies and Spinal Muscular Atrophy, Department of Physiology, University of Mississippi Medical Center02/2003
State/Local Invited Seminars/Lectures, Cajal bodies, Spinal Muscular Atrophy and Cancer, Department of Biochemistry, University of Mississippi Medical Center10/2002

Honors, Awards, and Recognition

Nelson Order, UMMC2015
Hall of Fame, Evers Society2015
“All-Star” Professor for excellence in teaching, Evers' Society2013
“All-Star” Professor for excellence in teaching, Chosen by medical students at UMMC (2011-2012). Medical Biochemistry won M1 basic science course of the year (for the fourth year in a row)2011
Postdoctoral Training Fellowship, National Institutes of Health1999
March of Dimes Scholarship Award, March of Dimes1990
All-Star Professor for Excellence in Teaching Award, University of Mississippi Medical Center (Medical Students)
HEADWAE Award, Mississippi State Legislature (UMMC Graduate School)
Basic Science Professor of the Year, University of Mississippi Medical Center (Medical Students)
Excellence in Research Award (Gold Level), University of Mississippi Medical Center
Excellence in Research Award (Silver Level), University of Mississippi Medical Center
Travel Grant Recipient and Invited Speaker, 3rd International Friedreich Ataxia Conference, National Institutes of Health
Young Investigator Travel Grant, National Ataxia Foundation
All Star Excellence in Teaching Award, University of Mississippi Medical Center (Medical Students)
Excellence in Research Award (Bronze Level), University of Mississippi Medical Center
Excellence in Teaching Awards, Georgia State University

Professional Membership and Service

American Society for Biochemistry and Molecular Biology, Member2021 - Present
Cancer Institute, University of Mississippi Medical Center, Associate Member2012 - Present
American Society for Cell Biology, Member2009 - Present
American Society for Microbiology, Member1992 - 1998
American Diabetes Association, Reviewer, Grant Proposal
Annals of Neurology, Reviewer, Journal Article
Ataxia UK, Reviewer, Grant Proposal
Austrian Research Fund, Reviewer, Grant Proposal
BMC Systems Biology, Reviewer, Journal Article
Cellular and Molecular Life Sciences, Reviewer, Journal Article
Chromosoma, Reviewer, Journal Article
European Journal of Neuroscience, Reviewer, Journal Article
Future Medicine, Reviewer, Journal Article
Gene Therapy, Reviewer, Journal Article
John Sealy Memorial Endowment Fund, Reviewer, Grant Proposal
Journal of Cell Biology, Reviewer, Journal Article
Journal of Cell Science, Reviewer, Journal Article
Muscular Dystrophy Association, Reviewer, Grant Proposal
Neuroscience Letters, Reviewer, Journal Article
PloSOne, Reviewer, Journal Article
Searle Scholars Program, Reviewer, Applications
Telethon, Reviewer, Grant Proposal
The US Civilian Research and Development Foundation, Reviewer, Grant Proposal
Wellcome Trust, Reviewer, Grant Proposal

Committee Service

GRE evaluation workgroup for the SGSHS, Member2021 - Present
Quality Enhancement Plan Committee of the Medical Center, Member2021 - Present
Chair of the Foundational Sciences Subcommittee of the SOM CC, Chair2021 - Present
Department of Cell and Molecular Biology Retreat Primary Presenter2021 - Present
Basic Sciences Workgroup of the Medical Center, Task Force Member2020 - 2021
Preclincal Coordinators Subcommittee of the SOM CC, Chair2019 - 2021
SOM Curriculum Committee Steering Committee, Member2019 - 2021
Annual Development of the Cell and Molecular Biology PhD program Institutional Effectiveness Plan2018 - Present
Cell and Molecular Biology Ph.D. Program Director2018 - Present
SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-GRADUATE COUNCIL2018 - Present
SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-CURRICULUM, Member2018 - Present
SCHOOL OF MEDICINE-CURRICULUM, Member2018 - Present
SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-GRADUATE PROGRAM REVIEW, Member2015 - Present
Grievance Committee for Graduate School, Member2010 - 2010
Point man for the Dept. of Biochemistry for submission of a T32 training grant2010 - Present
Medical Center - Research Advisory Committee, Member2010 - 2011
Ad Hoc Committee to develop a curriculum for a new Master of Science track in Biotechnology, Member2009 - Present
Graduate Student Academic Awards Committee, Member2009 - Present
Vice Chair of Medical Student Research Program, Vice Chair2009 - 2011
Reviewer for UMMC Intramural Research Support Program, Member2009 - 2009
School Of Graduate Studies - Curriculum Committee, Member2008 - Present
School Of Medicine - Admissions, Member2008 - Present
School Of Medicine Academic Awards Committee, Member2008 - Present
Completion of the UMMC Leadership Development Program2007 - 2008
Team to select speakers and judge posters for the UMMC graduate student research day, Member2007 - 2007
Department of Biochemistry, Annual Retreat Organizer2006 - 2008
Ad Hoc Committee for Graduate Student employee status, Member2006 - 2006
School Of Medicine - Curriculum, Member2005 - 2008
Research Space subcommittee, Member2005 - Present
Department of Biochemistry, Departmental Happy Hour Organizer2005 - 2008
Department of Biochemistry, Seminar Director2003 - 2008
Team to establish the Center for Investigation of Neurodegenerative Disease, Member

Community Service

Muscular Dystrophy Association Labor Day Telethon, TV appearance2007 - 2007
American Cancer Society Relay for Life, Participant2005 - 2006
Mississippi Academy of Science meeting, Judge2004 - 2004
Science Fair, Chastain Middle School, Judge2002 - 2002
Jackson Cancer Research Group (J-CRIG), Member

Teaching Experience

740, Biochemical Methods
744, Graduate, Course, Course Presenter, Cellular Biochemistry
727, Current Issues in Biomedical Research and Translational Medicine
710, Medicine, Course, Lecturer, Graduate Biochemistry
Professional Skills for Graduate Students and Postdoctoral Fellows
709, Course, Responsible Conduct of Research
Department of Biochemistry Journal ClubSpring 2012
701, Course, Course Coordinator, Basic Biochemistry in Health Care 2010
Small Group, Friedreich ataxia: From gene discovery to potential treatmentsFall 2007
Small Group, Nuclear Organization and DiseaseFall 2003

Directed Student Learning

Supervised Research, Advised: Zunamys Carrero2012 - 2013
Supervised Research, Advised: Hanna Broome2010 - Present
Supervised Research, Advised: Heather Douglas2010 - Present
Postdoctoral Advisor, Advised: Venkatramreddy Velma2009 - Present
Directed Individual/Independent Study, Advised: Andrew Gilder2008 - Present
Postdoctoral Advisor, Advised: Angela Whitton2008 - 2009
Postdoctorl Advisor, Advised: Cory Toyota2008 - 2009
Supervised Research, Advised: Scoty Hearst2008 - 2009
Supervised Research, Advised: Dustin Markle2008 - 2008
Supervised Research, Advised: Kenya Murray2008 - 2008
Supervised Research, Advised: Scoty Hearst2008 - 2008
Supervised Research, Advised: Andrew Gilder2007 - 2007
Supervised Research, Advised: Aruna Rawat2007 - 2007
Supervised Research, Advised: Nafez Abu Tarcoush2007 - 2007
Postdoctoral Research Advisor, Advised: Sandy Negi2006 - 2007
Supervised Research, Advised: Shama Moktan2006 - 2006
Supervised Research, Advised: Payal Vayas2004 - 2004
Supervised Research, Advised: Eric George2003 - 2003
Supervised Research, Advised: Iqbal Massodi2003 - 2003
Supervised Research, Advised: Xianghui Li2003 - 2003
Dissertation Committee Chair, Advised: Hongzhi Xu, Angela Reiken, Andrew Gilder
Dissertation Committee Member, Advised: Sheetal Bhan, Bob Sample, Iqbal Massodi, Payal Vyas, Moonsung Choi, Sandeep Negi, Naved Alam, Eric George, Lee Bidwell, Holland Alday, Ashish Aggarwal, Scoty Hearst
Postdoctoral Research Advisor, Advised: June Sun
Supervised Research, Advised: James Freeman, Dustin Markle
Supervised Research, Advised: James Freeman
Supervised Research, Advised: Kenya Murray
Supervised Research, Advised: Lee Bidwell, Eric George, Xianghui Li, Iqbal Massodi, Payal Vayas, Shama Moktan, Nafez Abu Tarboush, Aruna Rawat
Supervised Research, Advised: Tommy Nalls Jr.