Channabasavaiah B. Gurumurthy, PhD
Professor
Department:
SOM-Cell and Molecular Biology
Email:
cgurumurthy@umc.edu
Work Phone:
(601) 984-4309
Education
| University of Nebraska at Omaha, MBA, Executive MBA | 2012 |
| Indian Veterinary Reserach Institute, PhD, Virology | 2000 |
| Bangalore Veterinary College, DVM, Veterinary Medicine | 1993 |
Academic Appointments or Other Previous Appointments
| Professor, University of Nebraska Medical Center, School of Medicine | 03/2025 - 07/2020 |
| Director, University of Nebraska Medical Center, School of Medicine | 03/2025 - 07/2010 |
| Associate Professor, University of Nebraska Medical Center, School of Medicine | 06/2020 - 07/2016 |
| Assistant Professor, University of Nebraska Medical Center, School of Medicine | 06/2016 - 07/2010 |
| Instructor, University of Nebraska Medical Center, School of Medicine | 11/2007 - 06/2010 |
| Post Doctoral Fellow, Northwestern University, School of Medicine | 11/2003 - 10/2007 |
Publications
Journal Article | |
| Mesnard CS, Hays CL, Townsend LE, Barta CL, Gurumurthy CB, Thoreson WB, Synaptotagmin-9 in mouse retina. Visual neuroscience, 2024 Sep 18;41:E003 | 2024 |
| Miura H, Nakamura A, Kurosaki A, Kotani A, Motojima M, Tanaka K, Kakuta S, Ogiwara S, Ohmi Y, Komaba H, Schilit SLP, Morton CC, Gurumurthy CB, Ohtsuka M, Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT. BMC genomics, 2024 Jun 5;25(1):568 | 2024 |
| Deng Q, Lakra P, Gou P, Yang H, Meydan C, Teater M, Chin C, Zhang W, Dinh T, Hussein U, Li X, Rojas E, Liu W, Reville PK, Kizhakeyil A, Barisic D, Parsons S, Wilson A, Henderson J, Scull B, Gurumurthy C, Vega F, Chadburn A, Cuglievan B, El-Mallawany NK, Allen C, Mason C, Melnick A, Green MR, SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions. Cancer cell, 2024 Apr 8;42(4):605-622.e11 | 2024 |
| Arakawa H, Miura H, Quadros RM, Ohtsuka M, Gurumurthy CB, Cross-contamination of CRISPR guides and other unrelated nucleotide sequences among commercial oligonucleotides. Nucleic acids research, 2024 Apr 12;52(6):3137-3145 | 2024 |
| Du W, Ergin V, Loeb C, Huang M, Silver S, Armstrong AM, Huang Z, Gurumurthy CB, Staecker H, Liu X, Chen ZY, Rescue of Auditory Function by a Single Administration of AAV- TMPRSS3 Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8. bioRxiv : the preprint server for biology, 2023 Feb 26; | 2023 |
| Ohtsuka M, Imafuku J, Hori S, Kurosaki A, Nakamura A, Nakahara T, Yahata T, Bhat K, Papastefan ST, Nakagawa S, Quadros RM, Miura H, Gurumurthy CB, Delivering mRNAs to mouse tissues using the SEND system. bioRxiv : the preprint server for biology, 2023 Jan 29; | 2023 |
| Bhatia R, Siddiqui JA, Ganguly K, Thompson CM, Cannon A, Aithal A, Perumal N, Maurya SK, Li X, Cox JL, Gurumurthy CB, Rachagani S, Jain M, Nasser MW, Batra SK, Kumar S, Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis. Oncogene, 2023 Mar;42(10):759-770 | 2023 |
| Tanaka M, Yokoyama K, Hayashi H, Isaki S, Kitatani K, Wang T, Kawata H, Matsuzawa H, Gurumurthy CB, Miura H, Ohtsuka M, CRISPR-KRISPR: a method to identify on-target and random insertion of donor DNAs and their characterization in knock-in mice. Genome biology, 2022 Oct 25;23(1):228 | 2022 |
| Mesnard CS, Hays CL, Barta CL, Sladek AL, Grassmeyer JJ, Hinz KK, Quadros RM, Gurumurthy CB, Thoreson WB, Synaptotagmins 1 and 7 in vesicle release from rods of mouse retina. Experimental eye research, 2022 Dec;225:109279 | 2022 |
| Balog M, Anderson A, Gurumurthy CB, Quadros RM, Korade Z, Mirnics K, Knock-in mouse models for studying somatostatin and cholecystokinin expressing cells. Journal of neuroscience methods, 2022 Nov 1;381:109704 | 2022 |
| Gurumurthy CB, Quadros RM, Ohtsuka M, Prototype mouse models for researching SEND-based mRNA delivery and gene therapy. Nature protocols, 2022 Oct;17(10):2129-2138 | 2022 |
| Pop IV, Espinosa F, Blevins CJ, Okafor PC, Ogujiofor OW, Goyal M, Mona B, Landy MA, Dean KM, Gurumurthy CB, Lai HC, Structure of Long-Range Direct and Indirect Spinocerebellar Pathways as Well as Local Spinal Circuits Mediating Proprioception. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022 Jan 26;42(4):581-600 | 2022 |
| Miura H, Imafuku J, Kurosaki A, Sato M, Ma Y, Zhang G, Mizutani A, Kamimura K, Gurumurthy CB, Liu D, Ohtsuka M, Novel reporter mouse models useful for evaluating in vivo gene editing and for optimization of methods of delivering genome editing tools. Molecular therapy. Nucleic acids, 2021 Jun 4;24:325-336 | 2021 |
| Gurumurthy CB, Saunders TL, Ohtsuka M, Designing and generating a mouse model: frequently asked questions. Journal of biomedical research, 2021 Mar 26;35(2):76-90 | 2021 |
| Gurumurthy CB, Quadros RM, Richardson GP, Poluektova LY, Mansour SL, Ohtsuka M, Genetically modified mouse models to help fight COVID-19. Nature protocols, 2020 Dec;15(12):3777-3787 | 2020 |
| Urness LD, Wang X, Li C, Quadros RM, Harms DW, Gurumurthy CB, Mansour SL, Slc26a9(P2ACre) : a new CRE driver to regulate gene expression in the otic placode lineage and other FGFR2b-dependent epithelia. Development (Cambridge, England), 2020 Jul 8;147(13) | 2020 |
| Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G, Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome biology, 2019 Aug 26;20(1):171 | 2019 |
| Gurumurthy CB, Sato M, Nakamura A, Inui M, Kawano N, Islam MA, Ogiwara S, Takabayashi S, Matsuyama M, Nakagawa S, Miura H, Ohtsuka M, Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD. Nature protocols, 2019 Aug;14(8):2452-2482 | 2019 |
| Grassmeyer JJ, Cahill AL, Hays CL, Barta C, Quadros RM, Gurumurthy CB, Thoreson WB, Ca(2+) sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors. eLife, 2019 Jun 7;8 | 2019 |
| Gurumurthy CB, Lloyd KCK, Generating mouse models for biomedical research: technological advances. Disease models & mechanisms, 2019 Jan 8;12(1) | 2019 |
| Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A, Reprogramming human T cell function and specificity with non-viral genome targeting. Nature, 2018 Jul;559(7714):405-409 | 2018 |
| Ohtsuka M, Sato M, Miura H, Takabayashi S, Matsuyama M, Koyano T, Arifin N, Nakamura S, Wada K, Gurumurthy CB, i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases. Genome biology, 2018 Feb 26;19(1):25 | 2018 |
| Nakajima K, Zhou Y, Tomita A, Hirade Y, Gurumurthy CB, Nakada S, Precise and efficient nucleotide substitution near genomic nick via noncanonical homology-directed repair. Genome research, 2018 Feb;28(2):223-230 | 2018 |
| Miura H, Quadros RM, Gurumurthy CB, Ohtsuka M, Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors. Nature protocols, 2018 Jan;13(1):195-215 | 2018 |
| Jung EM, Moffat JJ, Liu J, Dravid SM, Gurumurthy CB, Kim WY, Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nature neuroscience, 2017 Dec;20(12):1694-1707 | 2017 |
| Quadros RM, Miura H, Harms DW, Akatsuka H, Sato T, Aida T, Redder R, Richardson GP, Inagaki Y, Sakai D, Buckley SM, Seshacharyulu P, Batra SK, Behlke MA, Zeiner SA, Jacobi AM, Izu Y, Thoreson WB, Urness LD, Mansour SL, Ohtsuka M, Gurumurthy CB, Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins. Genome biology, 2017 May 17;18(1):92 | 2017 |
| Sato M, Nakamura A, Sekiguchi M, Matsuwaki T, Miura H, Gurumurthy CB, Kakuta S, Ohtsuka M, Improved Genome Editing via Oviductal Nucleic Acids Delivery (i-GONAD): Protocol Steps and Additional Notes. Methods in molecular biology (Clifton, N.J.), 2023;2631:325-340 | |