Kristin S. Edwards
Assistant Professor
Department:
SOM-Pharmacology/Toxicology
Email:
kedwards1@umc.edu
Work Phone:
(601) 815-3423
Biography
Dr. Edwards is currently an assistant professor in the Department of Cell and Molecular Biology at UMMC. She received her BS degree in biology and chemistry from Jacksonville State University and her PhD in biochemistry from UMMC.
Her PhD research focused on the mechanisms by which the echinocandin group of antifungal drugs affect mitochondrial bioenergetics. Her postdoctoral research focused on the deficiency of the mitochondrial inner membrane protein, uncoupling protein 3, and its impairment of cardiac energetics and contractile recovery following ischemia and reperfusion. She has established protocols for isolating mitochondria from various tissues and measuring mitochondrial function, reactive oxygen species production, ATP production, and membrane potential. Her work has led to various awards, including the APS- Cardiovascular Section Research Recognition Award.
Dr. Edward’s current research focuses on the role of mitochondrial dysfunction associated with inflammatory bowel disease (IBD); the role of mitochondrial dysfunction in the comorbidities associated with IBD; and how mitochondrial targeted therapeutics are a beneficial treatment option for IBD and other human diseases.
Education
| University of Mississippi Medical Center, PhD, Biochemistry | 2017 |
| Jacksonville State University, BS, Biology and Chemistry | 2011 |
| University of Mississippi Medical Center, Postdoctoral Research Fellowship, Physiology |
Current Positions
| Assistant Professor, School of Medicine, Department of Pharmacology / Toxicology | 07/2023 - Present |
| Director, School of Medicine, Department of Pharmacology / Toxicology | 07/2023 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Mississippi Medical Center, School of Graduate School in the Health Sciences, Department of Cell and Molecular Biology | 05/2020 - 06/2023 |
| Assistant Professor, Jacksonville State University, Department of Chemistry and Geosciences | 2019 - 05/2020 |
| Postdoctoral Research Fellow, University of Mississippi Medical Center, School of Graduate School in the Health Sciences, Department of Physiology And Biophysics | 03/2017 - 11/2018 |
| Graduate Assistant, University of Mississippi Medical Center, School of Graduate School in the Health Sciences, Department of Biochemistry | 08/2011 - 03/2017 |
Publications
Journal Article | |
| Scasny A, Alibayov B, Khan F, Rao SJ, Murin L, Jop Vidal AG, Smith P, Li W, Edwards K, Warncke K, Vidal JE, Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to the cytotoxicity of human lung cells. Microbiology spectrum, 2024 Jan 11;12(1):e0291223 | 2024 |
| Littlejohn JB, Grenn EE, Carter KT, Palei AC, Spradley FT, Hosler JP, Hoang NH, Edwards KS, Kutcher ME, Increased platelet mitochondrial function correlates with clot strength in a rodent fracture model. The journal of trauma and acute care surgery, 2024 Mar 1;96(3):378-385 | 2024 |
| Alibayov B, Scasny A, Vidal AGJ, Murin L, Wong S, Edwards KS, Eichembaun Z, Punshon T, Jackson BP, Hopp MT, McDaniel LS, Akerley BJ, Imhof D, Vidal JE, Oxidation of hemoglobin in the lung parenchyma facilitates the differentiation of pneumococci into encapsulated bacteria. bioRxiv : the preprint server for biology, 2023 Nov 15; | 2023 |
| Scasny A, Alibayov B, Khan F, Rao SJ, Murin L, Jop Vidal AG, Smith P, Wei L, Edwards K, Warncke K, Vidal JE, Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells. bioRxiv : the preprint server for biology, 2023 Jun 7; | 2023 |
| Hosler J, Hoang N, Edwards KS, The cyclic lipopeptide micafungin induces rupture of isolated mitochondria by reprograming the mitochondrial inner membrane anion channel. Mitochondrion, 2023 Jul;71:50-62 | 2023 |
| Fitzgerald S, Deer E, Hogg J, Cornelius DC, Turner T, Amaral LM, Hoang N, Edwards K, Herrock O, Campbell N, Ibrahim T, LaMarca B, RUPP Th17s cause hypertension and mitochondrial dysfunction in the kidney and placenta during pregnancy. Pregnancy hypertension, 2023 Jun;32:50-56 | 2023 |
| Hoang N, Brooks K, Edwards K, Sex-specific colonic mitochondrial dysfunction in the indomethacin-induced inflammatory bowel disease model in rats. Research square, 2023 Mar 6; | 2023 |
| Pruett JE, Everman SJ, Hoang NH, Salau F, Taylor LC, Edwards KS, Hosler JP, Huffman AM, Romero DG, Yanes Cardozo LL, Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition. Biology of sex differences, 2022 Aug 19;13(1):45 | 2022 |
| Edwards KS, Ashraf S, Lomax TM, Wiseman JM, Hall ME, Gava FN, Hall JE, Hosler JP, Harmancey R, Uncoupling protein 3 deficiency impairs myocardial fatty acid oxidation and contractile recovery following ischemia/reperfusion. Basic research in cardiology, 2018 Oct 29;113(6):47 | 2018 |
| Lawson WJ, Shirey K, Spann RA, Zamarripa CA, Hosler JP, Grayson BE, Vertical sleeve gastrectomy improves indices of metabolic disease in rodent model of surgical menopause. Menopause (New York, N.Y.), 2017 Apr;24(4):426-436 | 2017 |
| Shirey K, Stover KR, Cleary J, Hoang N, Hosler J, Membrane-Anchored Cyclic Peptides as Effectors of Mitochondrial Oxidative Phosphorylation. Biochemistry, 2016 Apr 12;55(14):2100-11 | 2016 |
| Puskarich MA, Kline JA, Watts JA, Shirey K, Hosler J, Jones AE, Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock. Journal of critical care, 2016 Feb;31(1):63-7 | 2016 |
| Zouein FA, Duhé RJ, Arany I, Shirey K, Hosler JP, Liu H, Saad I, Kurdi M, Booz GW, Loss of STAT3 in mouse embryonic fibroblasts reveals its Janus-like actions on mitochondrial function and cell viability. Cytokine, 2014 Mar;66(1):7-16 | 2014 |
| Shirey, K. and Rayburn, J. Old World vs. New World: a preliminary comparison of the developmental toxicity of venom from two tarantula species, Grammostola rosea and Haplopelma lividium, using frog embryos from Xenopus laevis BIOS 84(3):127-135. DOI:10.1893/0005-3155-84.3.127 | 2013 |
| Vasumathi, N., Zettili, M., and Shirey, K. Bromination of dimethyl maleate using bromoform as catalyst under different energy sources: A case study for its role in biotransformations. Journal of the Alabama Academy of Science. 80 (3-4): 220-232. | 2009 |
| Vasumathi, N., Zettili, M., and Shirey, K. Effects of concentration, temperature, and varied energy conditions on the specific rotations of isoborneol and (s)-(-)-endo borneol. Journal of Undergraduate Chemistry Research. 8 (4):115-121. | 2008 |
| Konadu B, Hosler JP, Gibert Y, Edwards KS, Analysis of oxygen consumption rates in zebrafish reveals differences based on sex, age and physical activity recovery. Frontiers in physiology, 2023;14:1272366 | |
Book Chapter | |
| K. Shirey Jacksonville State University CY 232 Lab Manual Edition 2010: The effect of concentration and solvent on the rotatory power of a chiral compound | 2010 |
Presentations
| Invited Symposia, Central Renin Angiotensin System Dysregulation in the Parietal Cortex of Hyperandrogenic Female Mice: Implications for Cognitive Dysfunction in PCOS Women., ASPET 2024 | 05/2024 |
| Invited Symposia, Sex-specific colonic mitochondrial dysfunction and improvement with mitochondrial targeted therapies in the indomethacin-induced inflammatory bowel disease model in rats., UMDF Mitochondrial Medicine Conference 2023 | 06/2023 |
| Poster Presentation, Colonic Mitochondrial Dysfunction in Rodent Models of PCOS., UMDF Mitochondrial Medicine Conference 2023 | 06/2023 |
| Poster Presentation, Leptin Inhibition Ameliorates Renal Mitochondrial Dysfunction And Associated Renal Injury In Polycystic Ovary Syndrome, APS Summit | 04/2023 |
| Invited Symposia, Colonic Mitochondrial Dysfunction and Sub-Acute Gastrointestinal Inflammation in Two Hyperandrogenemic Rodent Models of PCOS, AE-PCOS 2023 | 04/2023 |
| Invited Symposia, Colonic Mitochondrial Dysfunction and Sub-Acute Gastrointestinal Inflammation in Two Hyperandrogenemic Rodent Models of PCOS., ENDO 2023 | 04/2023 |
| Poster Presentation, Altered mitochondrial function associated with hypercoagulability in a rodent fracture model., AAST 2023 | 2023 |
| Regional Invited Seminars/Lectures, Sex-specific effects of indomethacin-induced inflammatory bowel disease on mitochondrial function, Department of Physiology & Anatomy at the University of North Texas Health Science Center | 11/2022 |
| Poster Presentation, Sex-specific colonic mitochondrial dysfunction in the indomethacin-induced inflammatory bowel disease model in rats., UMMC Research Day | 11/2022 |
| Poster Presentation, Streptococcus pneumoniae Oxidizes Hemeproteins to Exacerbate Toxicity of Lung Cells and to Disrupt Mitochondrial Complex I Leading to Inhibition of Cellular Respiration., ASM Southcentral | 10/2022 |
| State/Local Invited Seminars/Lectures, Sex-specific effects of indomethacin-induced inflammatory bowel disease on mitochondrial function, Department of Chemistry at Mississippi State University | 04/2022 |
| Poster Presentation, Aging Female Offspring Exposed to Maternal Hyperandrogenemia have Increased Renal Mitochondrial Content and Decreased Mitochondrial Reactive Oxygen Species, Experimental Biology | 04/2022 |
| Invited Symposia, Sex-specific colonic mitochondrial dysfunction in the indomethacin-induced inflammatory bowel disease model in rats. *GIL Section Research Recognition Award, Experimental Biology | 04/2022 |
| Poster Presentation, Oxidative stress and white adipose tissue in a rat model of polycystic ovary syndrome., 2021 Androgen Excess- Polycystic Ovary Syndrome Meeting., Virtual | 11/2021 |
| Poster Presentation, Colonic mitochondrial function is altered in hyperandrogenemic female rats., APS New Trends in Sex and Gender Medicine conference, Vitrual | 10/2021 |
| Poster Presentation, Sodium-Glucose Cotransporter-2 Inhibition Improves Mitochondrial Dysfunction in White Adipose Tissue in Hyperandrogenemic Female Rats., APS New Trends in Sex and Gender Medicine conference, Virtual | 10/2021 |
| Poster Presentation, Sex-specific effects of indomethacin-induced inflammatory bowel disease on mitochondrial function, APS New Trends in Sex and Gender Medicine conference, Virtual | 10/2021 |
| Poster Presentation, Sex differences in mitochondrial dysfunction following the induction of Crohn’s Disease in rats, ACS National Meeting | 08/2021 |
Honors, Awards, and Recognition
| APS- Cardiovascular Section Research Recognition Award, APS | 2018 |
| Research Day Postdoctoral Poster Award, SGSHS | 2017 |
| Regions Outstanding Graduate Research Award, UMMC SGSHS | 2017 |
| Research Day Graduate Student Poster Winner, SGSHS | 2015 |
| Biology Outstanding Undergraduate Research Award, Jacksonville State University | 2011 |
| Biology Outstanding Academic Award, Jacksonville State University | 2011 |
| Biology Presentation, Jacksonville State University College of Arts and Sciences | 2011 |
| Richard J. Beschi Leadership Award, Jacksonville State University Department of Physical and Earth Sciences | 2010 |
Professional Membership and Service
| Endocrinology, Member | 2022 - Present |
| American Heart Association, Member | 2017 - Present |
| American Physiological Society, Member | 2017 - Present |
| American Society of Biochemistry and Molecular Biology, Member | 2015 - Present |
| National Society of Environmental Toxicology and Chemistry, Member | 2010 - 2011 |
| Regional Society of Environmental Toxicology and Chemistry, Member | 2010 - 2011 |
| Alabama Academy of Science, Member | 2009 - 2011 |
| Association of Southeastern Biologist, Member | 2009 - 2011 |
| American Chemical Society, Member | 2007 - Present |
Committee Service
| SCHOOL OF MEDICINE-ADMISSIONS FILE REVIEW SUBCOMMITTEE, Member | 2022 - Present |
| Women's Health Research Center, Member | 2022 - Present |
| Group on Women in Medicine and Science Executive Board, Member | 2022 - Present |
| Graduate Women in Medical Science Programming Committee, Member | 2020 - Present |
| JSU Chemistry Curriculum Committee, Member | 2019 - 2020 |
| JSU Faculty Commons Advisory Board Member, Member | 2019 - 2020 |
| JSU Chemistry Faculty Search Committee, Member | 2019 - 2019 |
| Postdoctoral Studies Advisory Committee, Member | 2017 - 2018 |
| Financial Aid Committee, Member | 2013 - 2014 |
| UMMC Graduate Student Body Philanthropy Committee, Member | 2013 - 2014 |
Community Service
| Rural Interdisciplinary Case Experience, Participant | 10/2015 - 10/2015 |
| UMMC Project REACH at Davis Magnet School, Volunteer Teacher | 08/2014 - 07/2016 |
| UMMC Discovery U, Volunteer | 03/2014 - 04/2018 |
Other Service
| Endocrinology Society’s Research Experiences for Graduate and Medical Students (REGMS) Award Application Reviewer | 2024 - Present |
| Endocrine Society’s Early Career Forum Application Reviewer | 2024 - Present |
| AHA pre-doctoral fellowship recommendations for two students (both awarded) | 08/2023 - Present |
| AHA Predoctoral and Postdoctoral Fellowship Reviewer | 08/2023 - Present |
| Journal Article Reviewer for Biomedicine & Pharmacotherapy | 07/2023 - Present |
| Jornal Article Reviewer for Journal of Physiology-Cell Physiology | 07/2022 - Present |
| Biology of Sex Differences | 05/2022 - Present |
| GWIMS Leadership Development Conference, Participant | 04/2022 - 12/2022 |
| Frontiers in Pharmacology | 03/2022 - Present |
| AHA Hypertension Journal | 02/2022 - Present |
| ACS Project SEED | 2020 - 05/2020 |
| JSU ACS Student Chapter, Faculty Advisor | 2019 - 05/2020 |
| UMMC Graduate Student Body, Secretary/Treasurer | 08/2015 - 05/2016 |
| UMMC Graduate Student Body, Secretary | 08/2014 - 05/2015 |
| Beta Beta Beta JSU Chapter, President | 08/2008 - 07/2010 |
Teaching Experience
| CMB 740, Graduate, Lecture, Lecturer, Biochemical Methods | Fall 2023-2024 |
| PH 723, Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2023-2024 |
| CMB 740, Graduate, Lecture, Lecturer, Biochemical Methods | Fall 2022-2023 |
| CMB 740, Graduate, Lecture, Lecturer, Biochemical Methods | Fall 2021-2022 |
| CMB740, Graduate, Lecture, Lecturer, Biochemical Methods | Fall 2020-2021 - 2020 |
Directed Student Learning
| Directed Individual/Independent Study, Advised: Viraj Patel | 2024 - 2024 |
| Directed Individual/Independent Study, Advised: Ashley Motton | 2022 - 2023 |
| Research Advisor, Advised: Hanna Bynum | 2021 - 2024 |
| Directed Individual/Independent Study, Advised: Sha'kiah Jones | 2021 - 2021 |
| Dissertation Committee Member, Adiponectin as a Potential Therapeutic Target for Cardiometabolic Complications in Polycystic Ovary Syndrome Advised: Ahmed Abdelhameed | |
| Dissertation Committee Member, Bisphenols exposure induces bone loss and osteoporosis by binding to and activating the endocannabinoid receptors Advised: Matthew Dubuisson | |
| Dissertation Committee Member, The Pathological Consequences of Streptococcus pneumoniae Produced Hydrogen Peroxide Advised: Anna Scasny |
Fellows supervised
| UMMC SGSHS, Research Advisor, 1 fellows supervised, Edwards | 05/2020 - Present |