Mauricio J. De Castro Pretelt, MD

Mauricio J. De Castro Pretelt, MD

Associate Professor

Department:
SOM-Peds-Genetics

Email:
mdecastro@umc.edu

Work Phone:
(601) 984-1900

Education

NIH/National Human Genome Research Institute, MD, Clinical Molecular Genetics2015
Johns Hopkins University SOM, MD, Medical Genetics2014
Keesler AFB, MD, Internal Medicine2012
Universidad Del Norte, Barranquilla, Colombia, MD, Doctor of Medicine2004

Specialty Certification Licensure

Certification, Internal Medicine Board Certification, American Board of Internal Medicine06/2012 - Present
Certification, Clinical Molecular Genetics Board Certification, American Board of Genetics & Genomics09/2015 - 12/2025
Certification, Clinical Genetics Board Certification, American Board of Genetics & Genomics09/2015 - 12/2025
Licensure, MS Medical License, State of MS05/2021 - 06/2022

Current Positions

Division Chief, School of Medicine08/2022 - Present
Assistant Professor, School of Medicine, Department of Pediatrics07/2018 - Present
Director07/2018 - Present
Genetics Chief Consultant to the Air Force Surgeon General, School of Medicine07/2018 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Sponsored Program Funding

Extramural, PopSeq: Return of Genomic Results and Estimating Penetrance in Population-Based Cohorts, Jackson Heart Study06/2022 - 06/2024
Extramural, Enabling Personalized Medicine through Exome Sequencing in the US Air Force. The MilSeq study, US Air Force-Harvard Medical School12/2016 - 12/2018

Publications

Journal Article

Venne V, Arfons L, De Castro M, Rider R, Thakar I Genomic Medicine and Genetic Counseling in the Department of Veterans Affairs and Department of Defense Federal Practitioner 2019 August;36(5):S15-S202019
Hellwig LD, Turner C, Manolio TA, Haigney M, James CA, Murray B, Szpisjak DF, Muldoon S, Estrada-Veras J, Krokosky A, De Castro MJ. Return of secondary findings in genomic sequencing: Military Implications. Mol Genet Genomic Med.2018 Nov 10. doi: 10.1002/mgg3.4832018
Núñez-Manchón J, Ballester-Lopez A, Koehorst E, Linares-Pardo I, Coenen D, Ara I, Rodriguez-Lopez C, Ramos-Fransi A, Martínez-Piñeiro A, Lucente G, Almendrote M, Coll-Cantí J, Pintos-Morell G, Santos-Lozano A, Arenas J, Martín MA, de Castro M, Lucia A, Santalla A, Nogales-Gadea G Correction to: Manifesting heterozygotes in McArdle disease: a myth or a reality-role of statins. J Inherit Metab Dis. 2018 Jul 20 doi: 10.1007/s10545-018-0236-6.2018
Núñez-Manchón J, Ballester-Lopez A, Koehorst E, Linares-Pardo I, Coenen D, Ara I, Rodriguez-Lopez C, Ramos-Fransi A, Martínez-Piñeiro A, Lucente G, Almendrote M, Coll-Cantí J, Pintos-Morell G, Lozano AS, Arenas J, Martín MA, de Castro M, Lucia A, Santalla A, Nogales-Gadea G. Manifesting heterozygotes in McArdle disease: a myth or a reality-role in statins. J Inherit Metab Dis.2018 Jun 20. doi: 10.1007/s10545-018-0203-22018
Ahrens-Nicklas R, Schlotawa L, Ballabio A, Brunetti-Pierri N, De Castro M, Dierks T, Eichler F, Ficicioglu C, Finglas A, Gaertner J, Kirmse B, Klepper J, Lee M, Olsen A, Parenti G, Vossough A, Vanderver A, Adang LA. Complex care of individuals with multiple sulfatase deficiency: Clinical cases and consensus statement. Mol Genet Metab.2018 Mar;123(3):337-346. doi: 10.1016/j.ymgme.2018.01.0052018
De Castro MJ, Turner CE Military genomics: a perspective on the successes and challenges of genomic medicine in the Armed Services. Mol Genet Genomic Med. 2017 Nov;5(6):617-620. doi: 10.1002/mgg3.335.2017
De Castro M, Biesecker LG, Turner C, Brenner R, Witkop C, Mehlman M, Bradburne C, Green RC. Genomic medicine in the military. NPJ Genom Med. 2016 Jan 13;1:15008. doi: 10.1038/npjgenmed.2015.82016
Bhasin B, Stiburkova B, De Castro M, Beck N, Bodhurta J, Atta M Hereditary renal hyperuricemia: A new role for allopurinol? Am J Med. 2014 Jan;127(1):e3-4. doi: 10.1016/j.amjmed.2013.08.025. Epub 2013 Nov 19. PMID: 24262806.2014
De Castro M Johann Gregor Mendel: paragon of experimental science. Mol Genet Genomic Med. 2016 Jan 8;4(1):3-8. doi: 10.1002/mgg3.1992014
Carroll M, De Castro M, Hust N, Smith D, Bashford M The relationship between two Xanthine oxidase single nucleotide polymorphisms to hyperuricemia, gout, and dose of xanthine oxidase inhibitor Journal of Musculoskeletal Research. Vol. 16, No. 01, 1350004 (2013)2013

Book Chapter

De Castro M, Turner C, Kirmse B Practical recommendations for the transition to adulthood for the adolescent with a genetic diagnosis. Special emphasis on inborn errors of metabolism Translational Science of Rare Diseases, vol. 4, no. 3-4, pp. 159-168, 20192020
Estrada JV, Ellsworth R, De Castro M, Turner C, Shriver C The Fundamentals of Precision Medicine

Presentations

Platform Presentations, The Wasteland Within the Desert: The Status of Adult Genetic Services in the Southeast Region of the United States, American College of Medical Genetics, Salt lake City,UT03/2023
Poster Presentation, A pilot study inegrating clincial genome sequencing into the US Air Force: Airmen percepetions and attitudes after receiving results in the MilSeq study, American Society of Human Genetics, Houston, TX10/2019
Poster Presentation, Broad genomic screening of active duty Air Force members: Findings from the Milseq study., American Society if Human Genetics, Houston, TX10/2019
Invited Symposia, Implementation of clinical grade next-generation sequencing in the DoD: Lessons learned and challenges ahead., Booz Allen Hamilton, Washington,DC09/2019
Regional Invited Seminars/Lectures, You and your genes: a deep dive into genetics, Gulf Coast Research Laboratory, Biloxi,MS04/2019
Poster Presentation, Healthy Genomic sequencing: What Airmen want to know? Findings from the MilSeq project., National Society of Genetic Counselors, Atlanta,GA11/2018
Poster Presentation, A new model for genomics support of military healthcare providers: early findings from the MilSeq project, American Society of Human Genetics, San Diego,CA10/2018
Poster Presentation, Airmen's attitudes towards genomic sequencing in the US Air Force: Results from the MilSeq project, American Society of Human Geneticsc, San Diego, CA10/2018
National and International Invited Seminars/Lectures, Whole exome sequencing in the military healthcare system: legal and ethical issues, The American Society of Law, Cleveland,OH06/2018
Poster Presentation, Subtle presentation of hypophosphatasia in a large kindred. Manifesting heterozygotes?, American College of Medical Genetics, Charlotte,NC04/2018
Poster Presentation, What's in a name? Extensive Turner syndrome stigmata in a 45X,46XY mosaic male. Implications for clinical management, American College of Medical genetics, Charlotte,NC04/2018
Poster Presentation, Pharmacogenomics in the US Air Force: development of a tailored panel for the MilSeq project., American College of Medical Genetics, Charlotte, NC04/2018
Poster Presentation, SMN1 Carrier screening in the department of defense populations: The first 1704 patients., American College of Medical genetics, Charlotte,NC04/2018
Poster Presentation, Special Considerations for Genomic Sequencing Research in the United States Air Force: Development of the MilSeq Project., American Society of Human Genetics, Orlando, FL10/2017
Regional Invited Seminars/Lectures, 2nd Personalized Medicine Symposium: Precision Medicine - Enhancing Health and Human Performance, Arlington, VA04/2015
National and International Invited Seminars/Lectures, "Gregor Mendel memorial lecture", NHGRI, Bethesda, MD03/2015

Honors, Awards, and Recognition

Company Grade Officer of the Quarter, United States Air Force2017

Professional Membership and Service

American College of Medical Genetics and Genomics, Fellow, Member of the Professional Practices and Guidelines Panel2021 - 2024
Multiple Sulfatase Deficiency Foundation, Board of Advisors of a Company2015 - Present
American College of Physicians, Member2009 - 2018
American Medical Association, Member2009 - Present

Committee Service

Genetics Advisory Committee, Member2023 - Present
Genetic Testing Stewardship Committee, Member2022 - Present
Professional Practices and Guidelines Committee, Member2020 - 2024
United Multiple Sulfatase Deficiency Foundation, Member2017 - Present
Keesler AFB - Cancer Activities Committee, Member2015 - Present
IOM Participant in the Institute of Medicine (IOM) roundtable on integration of genomic information into the EHR. Displaying and Integrating Genetic Information Through the EHR Action Collaborative, Member2014 - 2015
TRICARE Laboratory Working Group.Defense Health Agency, Member2013 - Present

Community Service

Special Olympics, Mississippi Chapter, Volunteer04/2023 - 04/2023
Special Olympics, Mississippi Chapter, Volunteer05/2022 - 05/2022
Pathways to Blues, Speaker09/2018 - 09/2018
Special Olympics, Mississippi Chapter, Volunteer05/2018 - 05/2018

Other Service

Roche Diagnostics06/2023 - 06/2023
Genetics in Medicine2018 - Present
American Journal Of Medical Genetics2018 - Present
Military Medicine2018 - Present
NIH Genetics Home Reference, Cytochrome P450 oxidoreductase deficiency
Molecular Genetics & Genomic Medicine

Teaching Experience

Medicine, Small Group, Lecturer, Project ECHO-Marfan SyndromeSummer 2023
Medicine, Lecture, Lecturer, Rheumatology Fellows Lecture-Hereditary Connective Tissue DisordersAnnual 2023 - 2023
Medicine, Lecture, Lecturer, Pediatric Grand Rounds-Hereditary Cancer syndromesSummer 2023
Medicine, Course, Attending, Clinical intro to Medical genetics-Medical StudentsSummer 2022 - 2022
Medicine, Lecture, Lecturer, Clinical Applicability of Genetics-Peds residentsAnnual 2020 - 2020
Medicine, Lecture, Lecturer, Clinical applicability of Genetics-Peds residentsAnnual 2019 - 2019

Directed Student Learning

Research Advisor, Advised: Alyssa Rondinelli2023 - 2023