Alexandre "Alex" A. Da Silva
Associate Professor
Department:
SOM-Physiology & Biophysics
Email:
asilva@umc.edu
Work Phone:
(601) 984-1829
Education
| University of Mississippi Medical Center, Postdoctoral Fellowship, Physiology - Hypertension | 2002 |
| University of Sao Paulo, Sao Paulo, Brazil, PhD, Physiology | 2001 |
| University of Sao Paulo, Sao Paulo, Brazil, BS, Biological Sciences | 1996 |
Current Positions
| Associate Professor, School of Medicine, Department of Physiology And Biophysics | 07/2024 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Physiology And Biophysics | 07/2021 - 06/2024 |
| Scientist IV, University of Mississippi Medical Center, School of Medicine | 12/2017 - 06/2021 |
| Professor, Centro Universitario Barao de Maua, School of Medicine | 2015 - 12/2017 |
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Physiology And Biophysics | 07/2006 - 12/2014 |
| Instructor, University of Mississippi Medical Center, School of Medicine, Department of Physiology And Biophysics | 08/2001 - 06/2006 |
| School of Medicine, Department of Physiology And Biophysics |
Sponsored Program Funding
| Extramural, Coress sex steroid therapy in the male rat and cardiovascular risk, NHLBI | 02/2024 - 01/2025 |
| Extramural, Mechanisms of renal disease progression in offspring from obese parents, NIDDK | 01/2024 - 12/2028 |
| Extramural, Cardiorenal and Metabolic Diseases Research Center - Phase III, NIGMS | 08/2023 - 07/2028 |
| Extramural, Cardiac protective mechanisms of melanocortin system activation, NHLBI | 01/2023 - 12/2026 |
| Extramural, Mechanism of PD1 on cardiac inflammation resolution during heart failure development, NHLBI | 02/2022 - 01/2026 |
| Extramural, Cardiorenal and Metabolic Diseases Research Center - Supplement, NIGMS | 07/2021 - 06/2023 |
| Extramural, Long-term consequences of parental obesity on developmental programing of cardiorenal diseases in offspring, NIDDK | 09/2019 - 07/2023 |
| Extramural, Cardiorenal and Metabolic Diseases Research Center - Phase II, NIGMS | 07/2018 - 06/2023 |
| Extramural, Protective cardiovascular effects of leptin in type-1 diabetes, CAPES-Brazil | 02/2015 - 10/2017 |
| Extramural, Cardiovascular Dynamics and Their Control, NHLBI | 08/2014 - 05/2019 |
| Extramural, Cardiorenal and Metabolic Diseases Research Center - Phase I, NIGMS | 09/2013 - 04/2018 |
| Intramural, Neurohumoral control of peripheral glucose homeostasis, University of Mississippi Medical Center | 11/2010 - 11/2011 |
| Extramural, Cardiovascular Dynamics and Their Control, NHLBI | 12/2008 - 10/2013 |
| Extramural, Antidiabetic and cardiovascular actions of leptin medicated by the central nervous system, American Heart Association | 07/2006 - 06/2010 |
| Extramural, Cardiovascular Dynamics and Their Control, NHLBI | 01/2004 - 12/2008 |
| Extramural, Role of melanocortin and sympathetic nervous system in mediating the actions of leptin in type-1 diabetes, American Heart Association | 07/2003 - 06/2005 |
Publications
Journal Article | |
| do Carmo JM, Hall JE, Dai X, Aitkens N, Larson K, Luna-Suarez EM, Wang Z, Omoto ACM, Mouton A, Li X, Furukawa LNS, Woronik V, da Silva AA. Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia/reperfusion injury in a sex-dependent manner. Am J Physiol Renal Physiol. 2024 ;326(5):F727-F736. | 2024 |
| Badmus OO, da Silva AA, Li X, Taylor LC, Greer JR, Wasson AR, McGowan KE, Patel PR, Stec DE. Cardiac lipotoxicity and fibrosis underlie impaired contractility in a mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD). FASEB Bioadv. 2024;6(5):131-142 | 2024 |
| Wang Z, Fu Y, da Silva AA, do Carmo JM, Mouton A, Omoto ACM, Li X, Sears J, Hall JE. Mitochondria-derived reactive oxygen species contribute to synergistic interaction of diabetes and hypertension in causing chronic kidney injury. Am J Physiol Renal Physiol. 2024 (Online ahead of print) | 2024 |
| Williamson A, da Silva AA, do Carmo JM, Le Maitre C, Hall JE, Aberdein N. Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight. Physiol Rep. 2023 (in press) | 2023 |
| do Carmo JM, Dai X, Aitken N, Larson K, Omoto ACM, Gulke R, Wang Z, Li X, Mouton AJ, Hall JE, da Silva AA Sex differences in weight gain, blood pressure control, and responses to melanocortin-4 receptor antagonism in offspring from lean and obese parents Am J Physiol Regul Integr Comp Physiol. 2023; (online ahead of print) | 2023 |
| Badmus OO, Kipp ZA, Bates EA, da Silva AA, Taylor LC, Martinez GJ, Lee WH, Creeden JF, Hinds TD Jr, Stec DE Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease Am J Physiol Regul Integr Comp Physiol. 2023; 325(1):R81-R95 | 2023 |
| Mouton AJ, Aitken NM, Moak SP, do Carmo JM, da Silva AA, Omoto ACM, LiX, Wang Z, Hall JE Temporal changes in glucose metabolism reflect polarization in resident and monocyte-derived macrophages after myocardial infarction Frontiers Cardiovasc Med. 2023; 10:1136252 | 2023 |
| Corrêa BSG, de Barros S, Vaz JB, Peres MA, Uchiyama MK, da Silva AA, Furukawa LNS COVID-19: Understanding the impact of anti-hypertensive drugs and hydroxychloroquine on the ACE1 and ACE2 in lung and adipose tissue in SHR and WKY rats Physiol Rep. 2023; 11(3):e15598 | 2023 |
| Omoto ACM, do Carmo JM, Nelson B, Aitken N, Dai X, Moak S, Flynn E, Wang Z, Mouton AJ, Li X, Hall JE, da Silva AA Central nervous system actions of leptin improve cardiac function after ischemia-reperfusion: role of sympathetic innervation and sex differences J Am Heart Assoc. 2022; 11(21):e027081 | 2022 |
| Bochi APG, Ferreira GDS, Del Bianco V, Pinto PR, Rodrigues LG, Trevisani MDS, Furukawa LNS, Bispo KCS, da Silva AA, Velosa APP, Nakandakare ER, Machado UF, Teodoro WPR, Passarelli M, Catanozi S Aerobic exercise training reduces atherogenesis induced by low-sodium diet in LDL receptor knockout mice Antioxidants (Basel). 2022; 11(10):2023 | 2022 |
| Wang Z, do Carmo JM, da Silva AA, Fu Y, Jaynes LT, Sears J, Li X, J Mouton A, Omoto ACM, Xu BP, Hall JE Transient receptor potential cation channel 6 deficiency leads to increased body weight and metabolic dysfunction Am J Physiol Regul Integr Comp Physiol. 2022; 323(1):R81-R97 | 2022 |
| da Silva AA, Moak SP, Dai X, Borges GC, Omoto ACM, Wang Z, Li X, Mouton AJ, Hall JE, do Carmo JM Parental obesity alters offspring blood pressure regulation and cardiovascular responses to stress: role of P2X7R and sex differences Am J Physiol Regul Integr Comp Physiol. 2022; 322(5):R421-R433 | 2022 |
| Li X, Flynn ER, do Carmo JM, Wang Z, da Silva AA, Mouton AJ, Omoto ACM, Hall ME, Hall JE Direct actions of sodium-glucose cotransporter 2 inhibition improve mitochondrial function and attenuate oxidative stress in pressure overload-induced heart failure Frontiers Cardiov Med. 2022; 9:859253 | 2022 |
| Wang Z, Fu Y, do Carmo JM, da Silva AA, Li X, Mouton A, Omoto ACM, Sears J, Hall JE Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension Am J Physiol Renal Physiol. 2022; 322(1):F76-F88 | 2022 |
| da Silva AA, Hall JE, Dai X, Wang Z, Salgado MC, do Carmo JM Chronic antidiabetic actions of leptin: evidence from parabiosis studies for a CNS-derived circulating antidiabetic factor Diabetes. 2021; 70(10):2264-2274 | 2021 |
| do Carmo JM, da Silva AA, Hall JE Impact of mineralocorticoid receptor and angiotensin II type 1 receptor antagonism on blood pressure regulation in obese Zucker rats: Role of sex differences Am J Hypertens. 2021; 34(9):999-1005 | 2021 |
| Mouton AJ, Flynn ER, Moak SP, Aitken NM, Omoto ACM, Li X, da Silva AA, Wang Z, do Carmo JM, Hall JE Dimethyl fumarate preserves left ventricular infarct integrity following myocardial infarction via modulation of cardiac macrophage and fibroblast oxidative metabolism J Mol Cell Cardiol. 2021; 158:38-48 | 2021 |
| do Carmo JM, Omoto ACM, Dai X, Moak SP, Mega GS, Li X, Wang Z, Mouton AJ, Hall JE, da Silva AA Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life Am J Physiol Heart Circ Physiol. 2021; 321(3):H485-H495 | 2021 |
| Li X, Lu Q, Qiu Y, do Carmo JM, Wang Z, da Silva AA, Mouton A, Omoto ACM, Hall ME, Li J, Hall JE Direct cardiac actions of the sodium glucose co-transporter 2 inhibitor empagliflozin improve myocardial oxidative phosphorylation and attenuate pressure-overload heart failure J Am Heart Assoc. 2021; 10(6):e018298 | 2021 |
| da Silva AA, Pinkerton MA, Spradley FT, Palei AC, Hall JE, do Carmo JM Chronic CNS-mediated cardiometabolic actions of leptin: potential role of sex differences Am J Physiol Regul Integr Comp Physiol. 2021; 320(2):R173-R181 | 2021 |
| ava FN, da Silva AA, Dai X, Harmancey R, Ashraf S, Omoto ACM, Salgado MC, Moak SP, Li X, Hall JE, do Carmo JM Restoration of cardiac function after myocardial infarction by chronic activation of the CNS leptin-melanocortin system JACC Basic Transl Sci. 2021; 6(1):55-70 | 2021 |
| Yalamanchili C, Chittiboyina AG, Haider S, Vasquez Y, Khan S, do Carmo JM, da Silva AA, Pinkerton M, Hall JE, Walker LA, Khan IA In search for potential antidiabetic compounds from natural sources: docking, synthesis and biological screening of small molecules from Lycium spp. (Goji) Heliyon. 2019; 6(1):e02782 | 2019 |
| do Carmo JM, da Silva AA, Gava FN, Moak SP, Dai X, Hall JE Impact of leptin deficiency compared with neuronal-specific leptin receptor deletion on cardiometabolic regulation Am J Physiol Regul Integr Comp Physiol. 2019; 317(4):R552-R562 | 2019 |
| Wang Z, do Carmo JM, da Silva AA, Bailey KC, Aberdein N, Moak SP, Hall JE Role of SOCS3 in POMC neurons in metabolic and cardiovascular regulation Am J Physiol Regul Integr Comp Physiol. 2019; 316(4):R338-R351 | 2019 |
| do Carmo JM, da Silva AA, Moak SP, da Silva FS, Spradley FT, Hall JE Role of melanocortin 4 receptor in hypertension induced by chronic intermittent hypoxia Acta Physiol (Oxf). 2019; 225(4):e13222 | 2019 |
| do Carmo JM, da Silva AA, Moak SP, Browning JR, Dai X, Hall JE Increased sleep time and reduced energy expenditure contribute to obesity after ovariectomy and a high fat diet Life Sci. 2018; 212:119-128 | 2018 |
| do Carmo JM, da Silva AA, Freeman JN, Wang Z, Moak SP, Hankins MW, Drummond HA, Hall JE Neuronal suppressor of cytokine signaling 3: role in modulating chronic metabolic and cardiovascular effects of leptin Hypertension. 2018; 71(6):1248-1257 | 2018 |
| da Silva AA, Freeman JN, Hall JE, do Carmo JM Control of appetite, blood glucose, and blood pressure during melanocortin-4 receptor activation in normoglycemic and diabetic NPY-deficient mice Am J Physiol Regul Integr Comp Physiol. 2018; 314(4):R533-R539 | 2018 |
| da Silva AA, Hall JE, do Carmo JM Leptin reverses hyperglycemia and hyperphagia in insulin deficient diabetic rats by pituitary-independent central nervous system actions PLoS One. 2017; 12(11):e0184805 | 2017 |
| do Carmo JM, da Silva AA, Romero DG, Hall JE Changes in ambient temperature elicit divergent control of metabolic and cardiovascular actions by leptin FASEB J. 2017; 31(6):2418-2428 | 2017 |
| Wang Z, do Carmo JM, Aberdein N, Zhou X, Williams JM, da Silva AA, Hall JE Synergistic interaction of hypertension and diabetes in promoting kidney injury and the role of endoplasmic reticulum stress Hypertension. 2017; 69(5):879-891 | 2017 |
| da Silva AA, Hall JE, Moak SP, Browning J, Houghton HJ, Micheloni GC, do Carmo JM Role of autonomic nervous system in chronic CNS-mediated antidiabetic action of leptin Am J Physiol Endocrinol Metab. 2017; 312(5):E420-E428 | 2017 |
| do Carmo JM, da Silva AA, Moak SP, Houghton HJ, Smith A, Hall JE Regulation of blood pressure, appetite and glucose by CNS melanocortin system in hyperandrogenemic female SHR Am J Hypertens. 2016; 29(7):832-40 | 2016 |
| do Carmo JM, da Silva AA, Wang Z, Freeman NJ, Alsheik AJ, Adi A, Hall JE Regulation of blood pressure, appetite, and glucose by leptin after inactivation of insulin receptor substrate 2 signaling in the entire brain or in proopiomelanocortin neurons Hypertension. 2016; 67(2):378-86 | 2016 |
| do Carmo JM, da Silva AA, Hall JE Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and metabolic functions in spontaneously hypertensive rats J Hypertens. 2015; 33(6):1201-6 | 2015 |
| da Silva AA, Spradley FT, Granger JP, Hall JE, do Carmo JM Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling J Neurophysiol. 2015; 113(7):2786-91 | 2015 |
| Bassi M, Nakamura NB, Furuya WI, Colombari DS, Menani JV, do Carmo JM, da Silva AA, Hall JE, Colombari E Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function Acta Physiol (Oxf). 2015; 213(4):893-901 | 2015 |
| da Silva AA, do Carmo JM, Dubinion JH, Bassi M, Mokhtarpouriani K, Hamza SM, Hall JE Chronic central nervous system MC3/4R blockade attenuates hypertension induced by nitric oxide synthase inhibition but not by angiotensin II infusion Hypertension. 2015; 65(1):171-7 | 2015 |
| do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation Am J Physiol Regul Integr Comp Physiol. 2014; 307(12):R1438-47 | 2014 |
| do Carmo JM, da Silva AA, Sessums PO, Ebaady SH, Pace BR, Rushing JS, Davis MT, Hall JE Role of Shp2 in forebrain neurons in regulating metabolic and cardiovascular functions and responses to leptin Int J Obes (Lond). 2014; 38(6):775-83 | 2014 |
| Bassi M, Furuya WI, Menani JV, Colombari DS, do Carmo JM, da Silva AA, Hall JE, Moreira TS, Wenker IC, Mulkey DK, Colombari E Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob/ob) mice Acta Physiol (Oxf). 2014; 211(1):240-8 | 2014 |
| Ying Z, do Carmo JM, Xiang L, da Silva AA, Chen M, Ryan MJ, Ostrowski M, Rajagopalan S, Hall JE Inhibitor κB kinase 2 is a myosin light chain kinase in vascular smooth muscle Circ Res. 2013; 113(5):562-70 | 2013 |
| do Carmo JM, da Silva AA, Rushing JS, Pace B, Hall JE Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons Am J Physiol Regul Integr Comp Physiol. 2013; 305(4):R359-68 | 2013 |
| Dubinion JH, do Carmo JM, Adi A, Hamza S, da Silva AA, Hall JE Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin Hypertension. 2013; 61(5):1066-74 | 2013 |
| Bassi M, do Carmo JM, Hall JE, da Silva AA Chronic effects of centrally administered adiponectin on appetite, metabolism and blood pressure regulation in normotensive and hypertensive rats Peptides. 2012; 37(1):1-5 | 2012 |
| Bassi M, Giusti H, Leite CM, Anselmo-Franci JA, do Carmo JM, da Silva AA, Hall JE, Colombari E, Glass ML Central leptin replacement enhances chemorespiratory responses in leptin-deficient mice independent of changes in body weight Pflugers Arch. 2012; 464(2):145-53 | 2012 |
| Ramos DR, Costa NL, Jang KL, Oliveira IB, da Silva AA, Heimann JC, Furukawa LN Maternal high-sodium intake alters the responsiveness of the renin-angiotensin system in adult offspring Life Sci. 2012; 90(19-20):785-92 | 2012 |
| do Carmo JM, da Silva AA, Rushing JS, Hall JE. Activation of the central melanocortin system contributes to the increased arterial pressure in obese Zucker rats Am J Physiol Regul Integr Comp Physiol. 2012; 302:R561-R567 | 2012 |
| do Carmo JM, da Silva AA, Morgan J, Jim Wang YX, Munusamy S, Hall JE. Inhibition of soluble epoxide hydrolase reduces food intake and increases metabolic rate in obese mice Nutr Metab Cardiovasc Dis. 2011; 22: 598-604 | 2011 |
| do Carmo JM, da Silva AA, Cai Z, Lin S, Dubinion JH, Hall JE. Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons Hypertension. 2011; 57:918-926 | 2011 |
| Dubinion JH, da Silva AA, Hall JE. Chronic blood pressure and appetite responses to central leptin infusion in rats fed a high fat diet J Hypertens. 2011; 29:758-762 | 2011 |
| do Carmo JM, Bassi M, da Silva AA, Hall JE Systemic but not central nervous system nitric oxide synthase inhibition exacerbates the hypertensive effects of chronic melanocortin-3/4 receptor activation Hypertension. 2011; 57:428-434 | 2011 |
| Dubinion JH, da Silva AA, Hall JE Enhanced blood pressure and appetite responses to chronic central melanocortin-3/4 receptor blockade in dietary-induced obesity J Hypertension. 2010; 28:466-470 | 2010 |
| do Carmo JM, Tallam LS, Roberts JV, Brandon EL, Biglane J, da Silva AA, Hall JE. Impact of obesity on renal structure and function in the presence and absence of hypertension: evidence from melanocortin-4 receptor deficient mice Am J Physiol Regul Integr Comp Physiol. 2009; 297:R803-R812 | 2009 |
| da Silva AA, do Carmo JM, Freeman JN, Tallam LS, Hall JE. A functional melanocortin system is required for the antidiabetic and cardiovascular actions of leptin in diabetic rats Diabetes. 2009; 58:1749-1756 | 2009 |
| do Carmo JM, Hall JE, da Silva AA. Chronic central leptin infusion restores cardiac sympathetic-vagal balance and baroreflex sensitivity in STZ-diabetic rats Am J Physiol Heart Circ Physiol. 2008; 295:H1974-H1981 | 2008 |
| da Silva AA, do Carmo JM, Kanyicska B, Dubinion J, Brandon E, Hall JE. Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats Hypertension. 2008; 51:884-890 | 2008 |
| da Silva AA, Tallam LS, Liu J, Hall JE. Chronic antidiabetic and cardiovascular actions of leptin: Role of CNS and increased adrenergic activity Am J Physiol Regul Integr Comp Physiol. 2006; 291:R1275-R1282 | 2006 |
| Liu J, da Silva AA, Tallam LS, Hall JE. Chronic CNS hyperinsulinemia and regulation of arterial pressure and food intake J Hypertens. 2006; 24:1391-1395 | 2006 |
| Tallam LS, da Silva AA and Hall JE. Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin Hypertension. 2006; 48:58-64 | 2006 |
| da Silva AA, Tallam LS, Liu J, Hall JE. Does obesity induce resistance to the long-term cardiovascular and metabolic actions of melanocortin 3/4-receptor activation? Hypertension. 2006; 47:259-264 | 2006 |
| Matos HR, Marques SA, Gomes OR, da Silva AA, Heimann JC, Di Mascio P, Medeiros MHG. Lycopene and beta-carotene protect in vivo DNA damage in rat lymphocytes Braz J Med Biol Res. 2006; 39:203-210 | 2006 |
| Tallam LS, Stec DE, da Silva AA, Kuo JJ and Hall JE Melanocortin-4 receptor deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia Hypertension. 2005; 46:326-332 | 2005 |
| Vidonho AF Jr, da Silva AA, Catanozi S, Rocha JC, Beutel A, Carillo BA, Furukawa LN, Campos RR, de Toledo Bergamaschi CM, Carpinelli AR, Quintão EC, Dolnikoff MS, Heimann JC Perinatal salt restriction: a new pathway to programming insulin resistance and dyslipidemia in adult Wistar rats Pediatr Res. 2004; 56(6):842-8 | 2004 |
| Tallam LS, Kuo JJ, da Silva AA, Hall JE Cardiovascular, renal, and metabolic responses to chronic central administration of agouti-related peptide Hypertension. 2004; 44(6):853-8 | 2004 |
| da Silva AA, Kuo JJ, Hall JE Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin Hypertension. 2004; 43(6):1312-7 | 2004 |
| Kuo JJ, da Silva AA, Tallam LS, Hall JE Role of adrenergic activity in pressor responses to chronic melanocortin receptor activation Hypertension. 2004; 43(2):370-5 | 2004 |
| da Silva AA, Kuo JJ, Tallam LS, Hall JE Role of endothelin-1 in blood pressure regulation in a rat model of visceral obesity and hypertension Hypertension. 2004; 43(2):383-7 | 2004 |
| de Paula RB, da Silva AA, Hall JE Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration Hypertension. 2004; 43(1):41-7 | 2004 |
| da Silva AA, de Noronha IL, de Oliveira IB, Malheiros DM, Heimann JC Renin-angiotensin system function and blood pressure in adult rats after perinatal salt overload Nutr Metab Cardiovasc Dis. 2003; 13(3):133-9 | 2003 |
| Kuo JJ, Silva AA, Hall JE Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function Hypertension. 2003; 41(3 Pt 2):768-74 | 2003 |
| Catanozi S, Rocha JC, Nakandakare ER, Passarelli M, Mesquita CH, Silva AA, Dolnikoff MS, Harada LM, Quintão EC, Heimann JC The rise of the plasma lipid concentration elicited by dietary sodium chloride restriction in Wistar rats is due to an impairment of the plasma triacylglycerol removal rate Atherosclerosis. 2001; 158(1):81-6 | 2001 |
Review Article | |
| Omoto ACM, do Carmo JM, da Silva AA, Hall JE, Mouton AJ. Immunometabolism, extracellular vesicles and cardiac injury. Front Endocrinol (Lausanne) 14:1331284, 2024. | 2024 |
| Mouton AJ, do Carmo JM, da Silva AA, Omoto ACM, Hall JE Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels . Frontiers in Physiol. 2023; 14:1139296 | 2023 |
| Hall JE, Mouton AJ, da Silva AA, Omoto ACM, Wang Z, Li X, do Carmo JM Obesity, kidney dysfunction, and inflammation: interactions in hypertension Cardiovasc Res. 2021; 117(8):1859-1876 | 2021 |
| Mouton AJ, Flynn ER, Moak SP, Li X, da Silva AA, Wang Z, do Carmo JM, Hall ME, Hall JE Interaction of obesity and hypertension on cardiac metabolic remodeling and survival following myocardial infarction J Am Heart Assoc. 2021; 10(6):e018212 | 2021 |
| da Silva AA, do Carmo JM, Hall JE CNS regulation of glucose homeostasis: role of the leptin-melanocortin system Curr Diab Rep. 2020; 20(7):29 | 2020 |
| da Silva AA, do Carmo JM, Li X, Wang Z, Mouton AJ, Hall JE Role of hyperinsulinemia and insulin resistance in hypertension: metabolic syndrome revisited Can J Cardiol. 2020; 36(5):671-682 | 2020 |
| Wang Z, do Carmo JM, da Silva AA, Fu Y, Hall JE Mechanisms of synergistic interactions of diabetes and hypertension in chronic kidney disease: role of mitochondrial dysfunction and ER stress Curr Hypertens Rep. 2020; 22(2):15 | 2020 |
| Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME Obesity, kidney dysfunction and hypertension: mechanistic links Nat Rev Nephrol. 2019; 15(6):367-385 | 2019 |
| da Silva AA, do Carmo JM, Wang Z, Hall JE Melanocortin-4 receptors and sympathetic nervous system activation in hypertension Curr Hypertens Rep. 2019; 21(6):46 | 2019 |
| do Carmo JM, da Silva AA, Wang Z, Fang T, Aberdein N, Perez de Lara CE, Hall JE Role of the brain melanocortins in blood pressure regulation Biochim Biophys Acta Mol Basis Dis. 2017; 1863(10 Pt A):2508-2514 | 2017 |
| do Carmo JM, da Silva AA, Wang Z, Fang T, Aberdein N, de Lara Rodriguez CE, Hall JE Obesity-induced hypertension: brain signaling pathways Curr Hypertens Rep. 2016; 18(7):58 | 2016 |
| Bassi M, Furuya WI, Zoccal DB, Menani JV, Colombari E, Hall JE, da Silva AA, do Carmo JM, Colombari DS Control of respiratory and cardiovascular functions by leptin Life Sci. 2015; 125:25-31 | 2015 |
| Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms Circ Res. 2015; 116(6):991-1006 | 2015 |
| da Silva AA, do Carmo JM, Wang Z, Hall JE The brain melanocortin system, sympathetic control, and obesity hypertension hysiology (Bethesda). 2014; 29(3):196-202 | 2014 |
| Hall ME, do Carmo JM, da Silva AA, Juncos LA, Wang Z, Hall JE Obesity, hypertension, and chronic kidney disease Int J Nephrol Renovasc Dis. 2014; 7:75-88 | 2014 |
| do Carmo JM, da Silva AA, Dubinion J, Sessums PO, Ebaady SH, Wang Z, Hall JE Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway IUBMB Life. 2013; 65(8):692-8 | 2013 |
| da Silva AA, do Carmo JM, Hall JE Role of leptin and central nervous system melanocortins in obesity hypertension Curr Opin Nephrol Hypertens. 2013; 22(2):135-40 | 2013 |
| Hall JE, Granger JP, do Carmo JM, da Silva AA, Dubinion J, George E, Hamza S, Speed J, Hall ME Hypertension: physiology and pathophysiology Compr Physiol. 2012; 2(4):2393-442 | 2012 |
| Hall JE, do Carmo JM, da Silva AA, Dubinion JD Pathophysiology of obesity and Hypertension: role of CNS leptin-melanocortin system J Hypertension. 2012; 30:e114-e115 | 2012 |
| Hall JE, da Silva AA, do Carmo JM, Dubinion J, Hamza S, Munusamy S, Smith G, Stec, DE. Obesity-induced hypertension: role of sympathetic nervous system, leptin and melanocortins J Biol Chem. 2010; 285:17271-17276 | 2010 |
| da Silva AA, do Carmo JM, Dubinion JH, Hall JE. Role of sympathetic nervous system in obesity related hypertension Curr Hypertens Rep. 2009; 11:206-211 | 2009 |
| da Silva AA. Mechanisms of obesity-induced hypertension: pathophysiological aspects Rev Bras Hipertens. 2005; 12:265-268 | 2005 |
| Hall JE, Henegar JR, Dwyer TM, Liu J, Da Silva AA, Kuo JJ, Tallam L Is obesity a major cause of chronic kidney disease? Adv Ren Replace Ther. 2004; 11(1):41-54 | 2004 |
| Hall JE, Jones DW, Kuo JJ, da Silva A, Tallam LS, Liu J Impact of the obesity epidemic on hypertension and renal disease Curr Hypertens Rep. 2003; 5(5):386-92 | 2003 |
| Hall JE, Kuo JJ, da Silva AA, de Paula RB, Liu J, Tallam L Obesity-associated hypertension and kidney disease Curr Opin Nephrol Hypertens. 2003; 12(2):195-200 | 2003 |
Abstracts | |
| Wang Z, Zhang H, Fan F, Sears J, Fu Y, Dai X, do Carmo JM, da Silva AA, Mouton AJ, Omoto ACM, Li X, Hall JE TRPC6 deficiency impairs middle cerebral artery myogenic response and brain spatial memory Physiology. 2023; 38(S1):5735117 | 2023 |
| da Silva AA, Dai X, Larson K, Aitken N, Frierson T, Walker X, Oppedal K, Omoto ACM, Wang Z, Li X, Mouton AJ, Hall JE, do Carmo JM Neonatal hyperoxia does not exacerbate hypertension in adult obese offspring from obese mothers Physiology. 2023; 38(S1):5731695 | 2023 |
| do Carmo JM, Mouton AJ, Aitken N, Wang Z, Dai X, Frierson T, Walker X, Oppedal K, Larson K, Omoto ACM, Li X, Hall JE, da Silva AA Parental obesity exacerbates immunometabolism and renal dysfunction in offspring exposed to acute kidney injury Physiology. 2023; 38(S1):5731221 | 2023 |
| Mouton AJ, Aitken N, Stanford J, Brown J, Schrimpe-Rutledge A, Codreanu S, Sherrod S, McLean J, da Silva AA, Do Carmo JM, Omoto ACM, Wang Z, Hall JE Glutamine metabolism improves cardiac function after myocardial infarction independent of macrophage polarization Physiology. 2023; 38(S1):5731449 | 2023 |
| Wang Z, Fu Y, Dai X, do Carmo JM, da Silva AA, Mouton AJ, Li X, Omoto ACM, Hall JE TRPC6 deficiency attenuates renal injury and mitochondrial dysfunction in ischemia/reperfusion-induced acute kidney injury Physiology. 2023;38(S1):5734736 | 2023 |
| Potential role of brown adipose tissue-derived extracellular vesicles in mediating the cardioprotective effect of CNS leptin infusion after ischemia/reperfusion injury Omoto ACM, Vechetti I, Rule B, do Carmo JM, da Silva AA, Aitken N, Dai X, Nelson B, Wang Z, Li X, Mouton AJ, Hall JE Physiology. 2023; 38(S1):5729450 | 2023 |
| Badmus O, Kipp ZK, Bates E, da Silva AA, Taylor L, Martinez G, Hinds T, Stec ED The loss of hepatic PPARα prompts fatty liver disease-induced hypertension and cardiovascular disease Physiology. 2023; 38(S1):5723348 | 2023 |
| Li X, Wang Z, do Carmo JM, da Silva AA, Mouton AJ, Omoto ACM, Hall JE Sestrin2 Prevents Excessive Cardiac Ischemia/Reperfusion Injury by Regulating Unfolded Protein Response Circulation. 2023; 146(Suppl_1):A14972-A14972 | 2022 |
| Omoto ACM, do Carmo JM, Nelson B, Aitken N, Dai X, Moak S, Wang Z, Mouton AJ, Li X, Hall JE, da Silva AA Role of Cardiac Sympathetic Nerves in Mediating the Central Nervous System Cardioprotective Effects of Leptin After Ischemia/Reperfusion Injury Circulation. 2022; 146(Suppl_1):A10134-A10134 | 2022 |
| da Silva AA, Moak S, Dai X, Borges GC, Omoto ACM, Gulke R, Wang Z, Li X, Mouton AJ, Hall JE, do Carmo JM Role Of Endogenous Brain Melanocortin-4 Receptor Activation In Regulating Blood Pressure And Metabolic Function In Offspring Of Parents With Obesity Hypertension. 2022; 79(Suppl_1):A112-A112 | 2022 |
| Nelson B, do Carmo ACM, Hall JE, da Silva AA, Omoto ACM High‐Frequency 4D Ultrasound Evaluation of Temporal Changes in Endocardial Surface Strain after Myocardial Infarction FASEB Journal 2022; 36(S1):L7440 | 2022 |
| do Carmo JM, Moak SP, Dai X, Borges GC, Omoto ACM, Wang Z, Li X, Mouton AJ, Hall JE, da Silva AA Parental obesity alters offspring blood pressure regulation and cardiovascular responses to stress: role of P2X7R and sex differences FASEB journal. 2022; 36(S1):R2877 | 2022 |
| Mouton AJ, Aitken N, Moak S, do Carmo JM, da Silva AA, Omoto ACM, Li X, Wang Z, Hall JE Metabolic Reprogramming Mediates Macrophage Polarization After Myocardial Infarction FASEB Journal. 2022; 36(S1):R3566 | 2022 |
| Wang Z, Fu Y, Sears J, da Silva AA, do Carmo JM, Li X, Mouton AJ, Omoto ACM, Hall JE Mitochondrial-derived ROS contributes to the development of hypertensive-diabetic kidney injury FASEB Journal. 2022; 36(S1):R2788 | 2022 |
| Omoto ACM, do Carmo JM, Nelson B, Flynn E, Aitken N, Wang Z, Mouton AJ, Li X, Moak SP, Dai X, Hall JE, da Silva AA Chronic central nervous system leptin infusion improves cardiac function and metabolism after ischemia/reperfusion injury FASEB Journal. 2023; 36(S1):R3740 | 2022 |
| da Silva AA, Omoto ACM, Dai X, Moak SP, Li X, Wang Z, Mouton AJ, Hall JE, do Carmo JM Sex Differences in the Impact of Parental Obesity on Offspring Cardiac SIRT3 Expression, Mitochondrial Efficiency and Diastolic Function Early in Life Circulation. 2021; 144(Suppl_1):A10230 | 2021 |
| Li X, Wang Z, do Carmo JM, da Silva AA, Mouton A, Omoto ACM, Hall JE Sestrin2 Plays an Essential Role in Regulating the Unfolded Protein Response During Cardiac Ischemia/Reperfusion and Preventing Excessive Myocardial Apoptosis Circulation. 2021; 144(Suppl_1):A13287 | 2021 |
| Omoto ACM, do Carmo JM, Li X, Wang Z, Mouton AJ, Aitken N, Moak S, Dai X, Hall JE, da Silva AA Chronic central nervous system leptin infusion increases cardiomyocyte mitochondrial function and biogenesis and improves cardiac function after ischemia-reperfusion injury Circulation Res. 2021; 129(Suppl_1):AP312 | 2021 |
| da Silva AA, Gava FN, Omoto ACM, Moak SP, Dai X, Hall JE, do Carmo JM Parental obesity leads to mild diastolic dysfunction and impaired exercise tolerance, but not hypertension, in female offspring Circulation. 2020; 142(Suppl_3):A14864 | 2020 |
| Omoto ACM, do Carmo JM, Flynn E, Moak SP, Li X, Mouton AJ, Wang Z, Hall JE, da Silva AA Chronic central nervous system actions of leptin protect against myocardial ischemia/reperfusion injury Circulation. 2020; 142:A16200 | 2020 |
| do Carmo JM, Moak SP, Dai X, Hall JE, da Silva AA Parental obesity exacerbates cardiovascular responses to acute stress in male, but not female, offspring FASEB Journal. 2020; 34(S1):1-1 | 2020 |
| SP Moak, Z Wang, AA da Silva, X Dai, JE Hall, JM do Carmo TRPC6 deficiency or feeding a high fat diet impairs ventilatory responses to hypercapnia FASEB Journal. 2020; 34(S1):1-1 | 2020 |
| Wang Z, Jaynes LT, Moak SP, Dai X, Fu Y, do Carmo JM, da Silva AA, HalL JE TRPC6 deficiency causes increased body weight and glucose intolerance in mice fed a normal diet but does not amplify the obesogenic effect of a high fat diet FASEB Journal. 2020; 34(S1):1-1 | 2020 |
| da Silva AA, Gava FN, Omoto ACM, Moak SP, Dai X, Hall JE, do Carmo JM Intergenerational inheritance of obesity-induced diastolic dysfunction with preserved ejection fraction Hypertension. 2019; 74(suppl 1):A090 | 2019 |
| do Carmo JM, da Silva AA, Gava FN, Moal SP, Dai X, Hall JE Impact of leptin deficiency compared to neuronal specific leptin receptor deletion on cardiometabolic regulation Hypertension. 2019; 74(suppl 1):A137 | 2019 |
| da Silva AA, Harmancey R, Dai Xuemei, Moak SP, Roy CN, Wang Z, Hall JE, do Carmo JM Differential Regulation of Cardiac Substrate Utilization in Response to Chronic Central Nervous System Administration of Leptin and Melanotan II in Rats with Myocardial infarction FASEB Journal. 2019; 33(suppl 1):532.10 | 2019 |
| Gava FN, da Silva AA, Ashraf S, Omoto ACM, Dai X, Pullman M, Harmancey R, Hall JE, do Carmo JM Chronic Intracerebroventricular Leptin Infusion Attenuates Cardiac Dysfunction After Myocardial Infarction FASEB Journal. 2019; 33(S1):830.6 | 2019 |
| Moak SP, Dai X, Hall JE, da Silva AA, do Carmo JM Impact of maternal obesity on body weight regulation and sleep time in offspring FASEB Journal. 2019; 33(S1):753.4 | 2019 |
| do Carmo JM, da Silva AA, Moak SP, Wang Z, Hall JE Metabolic and cardiovascular responses to chronic intermittent hypoxia and hypercapnia FASEB Journal. 2019; 33(S1):533.4 | 2019 |
| Bailey KC, Wang Z, Moak SP, Dai X, Fu Y, do Carmo JM, da Silva AA, Hall JE TRPC6 deficiency causes obesity and metabolic dysfunction FASEB Journal. 2019; 33(S1):753.1 | 2019 |
| Omoto ACM, do Carmo JM, da Silva AA, Salgado MC, Salgado HC, Fazan R, Hall JE Cardiac function and exercise capability in female Goto-Kakizaki type-2 diabetic rats after myocardial ischemia/reperfusion FASEB Journal. 2019; 33(Suppl. 1):690.4 | 2019 |
| Gava FN, da Silva AA, Hall JE, do Carmo JM Chronic central melanocortin 4 receptor activation attenuates cardiac dysfunction after myocardial infarction in rats Hypertension. 2018; 72 (suppl. 1):P192 | 2018 |
| Gava FN, Hall JE, da Silva AA, do Carmo JM Intergenerational obesity: impact on cardiac function and reserve in mice fed a high fat diet Hypertension. 2018; 72(suppl. 1):P294 | 2018 |
| Wang Z, do Carmo JM, da Silva AA, Moak SP, Bailey KC, Hall JE Trpc6 deficiency causes obesity, impaired glucose tolerance and leptin resistance Hypertension. 2018; 72(suppl. 1):A008 | 2018 |
| do Carmo JM, da Silva AA, Hall JE Evidence for a circulating factor released by the brain that contributes to chronic antidiabetic actions of leptin FASEB Journal. 2018; 32(Suppl. 1):603.3 | 2018 |
| Moak SP, da Silva AA, Hall JE, do Carmo JM Role of melanocortin-4 receptor activation in hypertension induced by chronic intermittent hypoxia FASEB Journal. 2018; 32(Suppl. 1):727.6 | 2018 |
| do Carmo JM, da Silva AA, Moak SP, Wang Z, Hall JE Metabolic and cardiovascular responses to chronic intermittent hypoxia and hypercapnia FASEB Journal. 2018; 32(Suppl. 1):533.4 | 2018 |
| Gava FN, da Silva AA, do Carmo JM Chronic central melanocortin 4 receptor blockade does not prevent cardiac dysfunction after myocardial infarction in rats Hypertension. 2017;60:P182 | 2017 |
| do Carmo JM, Freeman JN, da Silva AA, Moak SP, Hall JE Role of suppressor of cytokine signaling 3 (SOCS3) in the entire central nervous system in regulating metabolic and cardiovascular function in mice fed a high fat diet Hypertension. 2017; 60:P021 | 2017 |
| da Silva AA, Gava FN, Lataro, RM, Silva CMA, Salgado HC Chronic central leptin infusion improves cardiac function in STZ-diabetic rats with heart failure FASEB Journal. 2017; 31:853 | 2017 |
| do Carmo JM, da Silva AA, Moak SP, Wang Z, Hall JE Chronic inhibition of melanocortin 4 receptor (MC4R) attenuates hypertension-induced by intermittent hypoxia FASEB Journal. 2017; 31:1024.7 | 2017 |
| do Carmo JM, da Silva AA, Hall JE A novel selective melanocortin-4 receptor agonist attenuates bradycardia and hyperglycemia in diabetic rats Hypertension. 2016; 62:P312 | 2016 |
| Wang Z, do Carmo JM, da Silva AA, Aberdein N, Hall JE Role of suppressor of cytokines signaling 3 (SOCS3) in POMC neurons in regulating metabolic and cardiovascular functions in dietary-induced obesity Hypertension. 2016; 62: P077 | 2016 |
| do Carmo JM, da Silva AA, Yoo J, Moak SP, Spradley F, Hall JE Does chronic inhibition of brain endoplasmic reticulum stress alter metabolic and cardiovascular function in obese melanocortin-4 deficient rat? FASEB Journal. 2016; 30:964.1 | 2016 |
| do Carmo JM, da Silva AA, Wang Z, Hall JE Chronic inhibition of endoplasmic reticulum stress attenuates cardiovascular but not appetite responses to MC3/4R antagonist in SHR FASEB Journal. 2016; 30:959.3 | 2016 |
| do Carmo JM, Freeman JN, da Silva AA, Wang Z, Hall JE Role of Suppressor of Cytokines Signaling 3 (Socs3) in Modulating Chronic Metabolic and Cardiovascular Effects of Leptin Hypertension. 2015 66 (suppl 1):A085 | 2015 |
| Wang Z, do Carmo JM, da Silva AA, Hall JE Suppressor of Cytokine Signaling 3 (SOCS3) in POMC Neurons and Its Role in Regulating Blood Pressure, Body Weight and Glucose in Obesity Hypertension. 2015; 66(suppl 1):AP076 | 2015 |
| do Carmo JM, da Silva AA, Yoo J, Moak SP, Spradley FT, Hall JE Brain Endoplasmic Reticulum (ER) Stress Reduces Appetite and Increases Blood Pressure Independent of the Melanocortin-4 Receptor in Rats Hypertension. 2015; 66(suppl 1):A012 | 2015 |
| Wang Z, do Carmo JM, Williams J, da Silva AA, Hall JE Interaction of hypertension and diabetes in progressive nephropathy: role of ER stress FASEB Journal. 2015; 29:959.9 | 2015 |
| do Carmo JM, da Silva AA, Hall JE Effects of hyperandrogenemia on cardiovascular and metabolic responses to chronic melanocortin-4 receptor blockade in female SHR FASEB Journal. 2015; 29:647.2 | 2015 |
| da Silva AA, do Carmo JM, Hall JE Melanocortin-4 receptor signaling is required for the anorexic, cardiovascular and antidiabetic actions of leptin in diabetic rats Hypertension. 2014; 64 (suppl 1):A561 | 2014 |
| Maranon RO, Lima R, do Carmo JM, da Silva AA, Hall JE, Reckelhoff JF Role Of Melanocortin-4-receptor In The Blood Pressure Regulation In Female Hyperandrogenemic Rats, A Model Of Polycystic Ovary Syndrome Hypertension. 2014; 64(suppl_1), A245 | 2014 |
| do Carmo JM, da Silva AA, Hougton HJ, Moak SP, Smith A, Hall JE Impact of hyperandrogenemia on cardiovascular and metabolic function and ventilatory responses to hypercapnia in female SHRs Hypertension. 2014; 64(suppl 1):A209 | 2014 |
| da Silva AA, Pinkerton M, Spradley F, Palei A, do Carmo, JM Lack of sex difference in leptin-mediated regulation of appetite, cardiovascular function and glucose homeostasis FASEB Journal. 2014; 28:1083.5 | 2014 |
| da Silva AA, Pinkerton M, do Carmo JM Mice with MC4R rescued in forebrain neurons exhibit increased peripheral glucose uptake after acute central leptin infusion FASEB Journal. 2014; 28:854.3 | 2014 |
| do Carmo JM, Sessums P, Ebaady S, Freeman JN, Hall JE, da Silva AA Melanocortin-4 receptors in the PVN and RVLM are important in mediating cardiovascular responses to acute stress FASEB Journal. 2014; 28:686.7 | 2014 |
| Wang Z, do Carmo JM, da Silva AA, Hall JE Inhibition of endoplasmatic reticulum stress attenuates aorta coarctation induced hypertension and kidney injury in diabetic Goto-Kakizaki rats FASEB Journal. 2014; 28:LB724 | 2014 |
| do Carmo JM, da Silva AA, Wang Z, Hall JE Role of hindbrain endogenous melanocortin receptor activity in contributing to hypertension in SHR Hypertension. 2103; 62:A439 | 2013 |
| Wang Z, do Carmo JM, da Silva AA, Abraham R, Hall JE Interaction of Hypertension and Diabetes in Progressive Nephropathy, Enhanced ER Stress and Mitophagy in Goto Kakizaki Rats Hypertension. 2013; 62(suppl_1):A611 | 2013 |
| da Silva AA, Wang Z, Hall JE, do Carmo JM Hypophysectomy attenuates leptin-induced tachycardia without affecting leptin's action on appetite and body weight FASEB Journal. 2013; 27:1123.12 | 2013 |
| do Carmo JM, da Silva AA, Pace BR, Davis MT, Hall JE Cardiovascular and metabolic regulation in mice with neuron specific deletion of the leptin receptor FASEB Journal. 2013; 27:1153.6 | 2013 |
| do Carmo JM, da Silva AA, Sessums PO, Ebaady SH, Hall JE Shp2 signaling in Pomc neurons is important for leptin's actions on blood pressure, energy balance and glucose homeostasis FASEB Journal. 2013; 27:1120.3 | 2013 |
| Bassi B, Furuya WI, Menani JV, Colombari DSA, do Carmo JM, da Silva AA, Hall JE, Wenker IC, Mulkey D, Colombari E Effects of leptin in the retrotrapezoid nucleus (RTN) on CO2-sensitivity and respiration FASEB Journal. 2013; 27:1120.3 | 2013 |
| do Carmo JM, da Silva AA, Hall JE Leptin Reduces Food Intake but Fails to Raise Blood Pressure In Mice With Deficiency of Insulin Receptor Substrate (IRS2) In the Entire Brain or Specifically in Pomc neurons Hypertension. 2012; 60:A27 | 2012 |
| do Carmo JM, da Silva AA, Hall JE. AT1 receptor antagonism but not mineralocorticoid receptor blockade lowers blood pressure in obese Zucker rats FASEB Journal. 2012; 26:1093.6 | 2012 |
| da Silva AA, do Carmo JM, Dubinion JH, Hall JE. Ganglionic blockade does not impair the chronic CNS-mediated antidiabetic action of leptin in streptozotocin-induced diabetic rats FASEB J. 2012; 26:1128.3 | 2012 |
| do Carmo JM, da Silva AA, Hall JE. Metabolic and appetite responses to fasting and refeeding in mice with Shp2 deletion in forebrain neurons FASEB Journal. 2012; 26:877.2 | 2012 |
| do Carmo JM, da Silva AA, Rushing JS, Munusamy S, Dubinion J, Hamza S, Hall M, Hall JE. Differential control of appetite and cardiovascular function after rescue of melanocortin-4 receptors in proopiomelanocortin neurons Hypertension. 2011; 58(5):e39 | 2011 |
| Dubinion J, do Carmo M, Munusamy S, Hamza S, da Silva AA, Hall JE. Stat3 inactivation in POMC neurons attenuates leptin-induced elevation in arterial pressure Hypertension. 2011; 58(5):e36 | 2011 |
| do Carmo JM, da Silva AA, Rushing JS, Hall JE. Cardiovascular and metabolic responses to chronic central MC3/4R antagonism in obese Zucker rats FASEB Journal. 2011; 25:823.6 | 2011 |
| do Carmo JM, Bassi M, Hamza SM, da Silva AA, Hall JE. Cardiovascular and metabolic responses to thermoneutrality and cold ambient temperature in lean and obese leptin deficient mice FASEB Journal. 2011; 25:1028.4 | 2011 |
| da Silva AA, Dubinion JD, do Carmo JM, Hall JE. Chronic Central Nervous System MC3/4R Blockade Attenuates the Hypertension Induced by Peripheral Nitric Oxide Synthase Inhibition but not by Angiotensin II Infusion Hypertension. 2010; 56:E105-E105 | 2010 |
| do Carmo JM, da Silva AA, Hall JE. Divergent Chronic Metabolic and Cardiovascular Responses to Leptin: Effects of Ambient Temperature Hypertension. 2010; 56:E103-E104 | 2010 |
| Freeman JN, do Carmo JM, Hall JE, da Silva AA. Central NPY deficiency does not enhance the chronic actions of melanocortin 3 and 4 receptors (MC3/4R) activation on glucose homeostasis, appetite and cardiovascular function in diabetic mice FASEB Journal. 2010; 24:597.6 | 2010 |
| do Carmo JM, Bassi M, da Silva AA, Hall JE. Chronic central nervous system MC3/4R activation exacerbates the cardiovascular responses to peripheral nitric oxide synthase inhibition FASEB J. 2010;24:1051.1 | 2010 |
| Bassi M, do Carmo JM, da Silva AA, Hall JE. Chronic CNS actions of adiponectin on appetite, metabolism and cardiovascular function. FASEB J. 2010 24:780.1 | 2010 |
| do Carmo JM, da Silva AA, Morgan J, Hall JE. Inhibition of soluble epoxide hydrolase reduces food intake and increases metabolic rate in mice fed high fat-high fructose diet FASEB J. 2010; 24:996.2 | 2010 |
| Freeman JN, do Carmo JM, Hall JE, da Silva AA. Central neuropeptide Y (NPY) deficiency does not enhance the dietary or cardiovascular responses to chronic activation of melanocortin 3 and 4 receptors (MC3/4R) Hypertension. 2009; 54:e103 | 2009 |
| do Carmo JM, Bassi M, da Silva AA, Hall JE. Consequences of prolonged obesity on cardiovascular, metabolic and respiratory functions in leptin-deficient and diet-induced obese mice Hypertension 2009; 54:e104 | 2009 |
| do Carmo JM, da Silva AA, Hall JE. Divergent control of appetite, cardiovascular and metabolic functions by leptin in mice lacking leptin receptor in POMC neurons Hypertension. 2009; 54:e102 | 2009 |
| do Carmo JM, da Silva AA, Hall JE. Cardiovascular and metabolic regulation in mice with Shp2 deletion in forebrain neurons FASEB Journal. 2009; 23:785.5 | 2009 |
| Dubinion JH, da Silva AA, do Carmo JM, Hall JE. Cardiovascular and metabolic responses to chronic central infusion of leptin in rats fed a high fat diet FASEB Journal. 2009; 23:1015.5 | 2009 |
| Dubinion JE, da Silva AA, do Carmo JM, Hall JE. Cardiovascular and metabolic responses to chronic PYY3-36 infusion FASEB Journal. 2009; 23:983.4 | 2009 |
| da Silva AA, do Carmo JM Chronic CNS actions of ghrelin on appetite, body weight, and cardiovascular function Hypertension. 2008; 52(4):E129 | 2008 |
| do Carmo JM, da Silva AA, Hall JE Impaired spontaneous baroreflex sensitivity and absence of hypertension in old leptin deficient obese mice Hypertension. 2008; 52(4):E104 | 2008 |
| Dubinion JH, da Silva AA, Dreher A, Hall JE. Cardiovascular and metabolic responses to chronic central MC3/4R antagonism in rats fed a high fat diet FASEB Journal. 2008; 22:947.4 | 2008 |
| do Carmo JM, da Silva AA, Brandon E, Hall JE. Cardiovascular function and metabolism in old melanocortin-4 receptor deficient obese mice FASEB Journal. 2008; 22:947.2 | 2008 |
| da Silva AA, do Carmo JM, Freeman JN, Hall JE. Chronic MC3/4R activation does not mimic the actions of leptin on baroreceptor sensitivity and heart rate regulation in diabetic rats. FASEB Journal. 2008; 22:947.5 | 2008 |
| Brandon E, do Carmo JM, da Silva AA, Hosler JP, Hall JE. Renal lipid accumulation and mitochondrial function in leptin deficient and melanocortin-4 receptor deficient obese mice FASEB J. 2008; 22:947.3 | 2008 |
| do Carmo JM, Hall JE, da Silva AA Chronic central leptin infusion restores sympatho-vagal balance, cardiovascular variability and baroreflex sensitivity in diabetic rats Hypertension. 2007; 50(4):E92 | 2007 |
| da Silva AA, Tallam LS, Liu J, Brandon E, Hall JE. A functional melanocortin system is required for the CNS actions of leptin on peripheral glucose regulation and cardiovascular function FASEB J. 2006; 20:A1168 | 2006 |
| Tallam LS, Roberts JV, da Silva AA, Hall JE. Impact of obesity on renal structure and function in the sbsence of hypertension: Evidence from melanocortin-4 receptor (MC4R) deficient mice FASEB J. 2006; 20:A1168 | 2006 |
| da Silva AA, Tallam LS, Liu J, Hall JE CNS actions of leptin play a major role in peripheral glucose regulation independent of adrenergic activation Hypertension. 2005; 46(4):823 | 2005 |
| Tallam LS, da Silva AA, Hall JE Role of the melancortin-4 receptor (MC4R) in mediating the chronic cardiovascular and metabolic actions of leptin Hypertension. 2005; 46(5):822 | 2005 |
| da Silva AA, Kuo JJ, Tallam LS, Liu JK, Hall JE Role of the central melanocortin system in regulating arterial pressure in SHR Hypertension. 2005; 46(4):867 | 2005 |
| da Silva AA, Kuo JJ, Brown P, Tallam LS, Liu J and Hall JE Chronic cardiovascular, metabolic and renal actions of central hyperleptinemia in type-1 diabetic rats FASEB Journal. 2005; 19(4):A631 | 2005 |
| Tallam LS, Stec DE, da Silva AA and Hall JE Renal Changes in Severely Obese Normotensive Melanocortin-4 Receptor Deficient (MC4R (-/-)) Mice. Experimental Biology FASEB Journal. 2005; 19(5):A1581 | 2005 |
| Meng S, da Silva AA, Liu J, Kuo JJ, Tallam LS, Hall JE Role of oxidative stress in mediating chronic cardiovascular actions of leptin Hypertension. 2004; 44(4):504 | 2004 |
| Liu J, da Silva AA, Meng S, Hall JE Chronic central infusion of insulin transiently decreases food intake without changing arterial pressure and heart rate in rats Hypertension.2004; 44(4):560 | 2004 |
| Tallam LS, Stec DE, da Silva AA, Kuo JJ and Hall JE Melanocortin-4 receptor deficient mice are neither hypertensive nor salt-sensitive despite obesity Hypertension. 2004; 44(4):503 | 2004 |
| da Silva AA, Kuo JJ, Tallam L, Hall JE Blood pressure regulation in rats whose mothers were fed a low protein diet during gestation: role of endothelin-1 FASEB Journal. 2004; 18(4):A738-A739 | 2004 |
| Kuo JJ, da Silva AA, Tallam LS, and Hall JE Chronic Cardiovascular and Renal Actions of Melanin-Concentrating Hormone FASEB Journal. 2004; 18 (4):A297 | 2004 |
| Tallam LS, Kuo JJ, da Silva AA and Hall JE Role of Agouti Related Peptide in Chronic Regulation of Cardiovascular and Renal Function FASEB Journal. 2004; 18(4):A294 | 2004 |
| AA da Silva, JJ Kuo, LS Tallam, J Liu, JE Hall Chronic cardiovascular and dietary responses to activation of melanocortin 3/4 receptors in a model of diet-induced obesity J Hypertension. 2004; 22:S202 | 2004 |
| Vidonho Jr. AF, Furukawa LNS, da Silva AA, Nascimento CA, Heimann JC Salt restriction during the perinatal period: a new pathway to insulin resistance and dyslipidemia on adulthood J Hypertension. 2004; 22:S98 | 2004 |
| Kuo JJ, da Silva AA, Tallam LS, Hall JE Role of adrenergic activity in cardiovascular and renal responses to chronic melanocortin receptor activation Hypertension. 2003; 42(3):422 | 2003 |
| da Silva AA, Kuo JJ, Tallam LS, Hall JE Role of endothelin in blood pressure regulation in a model of diet-induced obesity Hypertension. 2003; 42(3):422 | 2003 |
| Vidonho Jr. AF, Furukawa LNS, da Silva AA, Heimann JC Salt intake during pregnancy and lactation influences blood pressure, insulin sensitivity, and plasma lipid profile in adult offspring Pediatric Research. 2003; 53(6):5A | 2003 |
| de Paula RB, da Silva AA, Hall JE Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration Am J Hypertension. 2003; 16(S3):238 | 2003 |
| da Silva AA, Kuo JJ, Hall JE Hypothalamic Melanocortin-3/4 Receptor Inhibition Abolishes the Dietary and Cardiovascular Responses to Chronic Leptin Infusion FASEB Journal. 2003; 17(4):A156 | 2003 |
| Kuo JJ, da Silva AA, Hall JE Chronic cardiovascular and renal responses to chronic hypothalamic melanocortin-4 receptor activation or inhibition Hypertension. 2002; 40(3):386 | 2002 |
| Vidonho Jr. AF, Furukawa LNS, da Silva AA, Heimann JC Blood pressure and insulin sensitivity in adult offspring are influenced by maternal salt intake during pregnancy and lactation J Hypertension. 2002; 20:S59 | 2002 |
| Kuo JJ, da Silva AA, Hall JE Cardiovascular and renal responses to chronic hypothalamic melanocortin-4 receptor blockade FASEB Journal. 2002; 16(5):A793 | 2002 |
| Perinatal salt overload leads to higher blood pressure, lower salt sensitivity, and loss of the renin-angiotensin system modulation by salt in the adult offspring da Silva AA, Heimann JC J Hypertension. 2000; 18(4):S125 | 2000 |
| da Silva AA, Braga IO, Noronha IL, Malheiros DMAC, Heimann JC Efeitos da sobrecarga salina no período perinatal sobre a pressão arterial e sistema renina-angiotensina na idade adulta Rev Bras Hipertensao. 2000; 3(suppl_1) | 2000 |
| da Silva AA, Heimann JC Dietary salt overload during pregnancy and lactation increases blood pressure, and decreases salt sensitivity and the modulation of the renin-angiotensin system in response to salt in adult offspring Hypertension. 1999; 34(2):365 res. P-140 | 1999 |
| Catanozi S, Passarelli M, Rocha JC, da Silva AA, Nakandakare EN, Mesquita CH, Harada LM, Dolnikoff MS, Heimann JC, Quintao ECR On low salt diet, a high plasma triglyceride concentration is associated with normal triglyceride production J Hypertension. 1998; 16:S14 | 1998 |
| da Silva AA, Furukawa LNS, Santos EA, Heimann JC The consequences on the offspring due to chronic salt overload during pregnancy J Hypertension. 1998; 16:S267 | 1998 |
| Catanozi S, Passarelli M, Rocha JC, da Silva AA, Nakandakare EN, Mesquita CH, Harada LM, Dolnikoff MS, Heimann JC, Quintao ECR Low salt consumption increases plasma triglyceride despite a normal production rate. Am J Hypertension. 1998; 11(S4):208A | 1998 |
| da Silva AA, Furukawa LNS, Santos EA, Heimann JC Salt overload before and during pregnancy: effects on the dams and offspring Am J Hypertension. 1998; 11(S4):91A | 1998 |
Dissertation | |
| da Silva AA Efeitos da sobrecarga ou restrição crônica de sal na dieta durante a gestação e amamentação em ratas Wistar e sua repercussão sobre a prole 10.11606/T.5.2001.tde-19052004-175504 | 2001 |
Book Chapter | |
| Hall JE, Omoto ACM, do Carmo JM, da Silva AA, Wang Z, Mouton AJ, Li X, Hall ME Obesity and Hypertension In: “Handbook of Obesity 5th Edition, Volume I: Epidemiology, Etiology and Physiopathology” (in press) | 2023 |
| Hall ME, Omoto ACM, do Carmo JM, da Silva AA, Hall JE Obesity and Hypertension: Pathophysiology and Treatment In “Hypertension: A Companion to Braunwald’s Heart Disease 4th Edition” (in press) | 2023 |
| da Silva AA, do Carmo JM, Wang Z, Hall JE Leptin, the autonomic nervous system, and hypertension In: Leptin. Ed. Samuel Dagogo-Jack. Springer New York, 2014. P-175-188. | 2015 |
| Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME Role of the kidney in hypertension In: Hypertension. Eds. EL Schifrin and RM Touyz. Future Science Group, 2013. Pp 2-19 | 2014 |
| Hall JE, da Silva AA, Brandon E, Stec DE, Ying Z, Jones DW Pathophysiology of obesity-induced hypertension and target organ damage In “Comprehensive Hypertension”, Elsevier, New York, NY, 447-468, 2007 | 2007 |
| Hall JE, Jones DW, Kuo JJ, da Silva AA, Liu J, Tallam LS Obesity and Hypertension: impact on cardiovascular and renal systems In “Hypertension: A Companion to Brenner and Rector’s The Kidney, 2nd Edition, 2004 | 2004 |
| JC Heimann, AA da Silva, MS Coelho, PO Prada Restrição do consumo de sal para o tratamento da hipertensão arterial: mitos e fatos. In “Atualidades em Nefrologia” – 6 Sarvier Editora de Livros Médicos Ltda, São Paulo, SP – Brazil, 2000. (Portuguese) | 2000 |
| AA Silva, JC Heimann O ambiente perinatal: repercussão sobre a prole. In “Atualidades em Nefrologia” - 5. Sarvier Editora de Livros Médicos Ltda, São Paulo, SP – Brazil, 1998. (Portuguese) | 1998 |
Editorial Commentary | |
| Sun X, Ruan C, da Silva AA Editorial: The impact of adipose tissue dysfunction on cardiovascular and renal disease, Volume II Front Endocrinol (Lausanne). 2023; 14:1223983 | 2023 |
| Sun X, Ruan CC, da Silva AA Editorial: The Impact of Adipose Tissue Dysfunction on Cardiovascular and Renal Disease Front Endocrinol (Lausanne). 2022; 12:815894 | 2022 |
Presentations
| State/Local Invited Seminars/Lectures, Central nervous systems control of glucose homeostasis and cardiac function during activation of the leptin-melanocortin system pathway, UMMC - Department of Physiology and Biophysics Seminar Series, Jackson, MS | 03/2023 |
| National and International Invited Seminars/Lectures, Role of endogenous brain melanocortin-4 receptor activation in regulating blood pressure and metabolic function in offspring of parents with obesity, American Heart Association - Hypertension Meeting, San Diego, CA | 09/2022 |
| Regional Invited Seminars/Lectures, Mechanisms of the powerful antidiabetic and cardioprotective actions of the brain leptin-melanocortin system axis, Multi-COBRE Seminar Series, Online platform | 08/2022 |
| National and International Invited Seminars/Lectures, Regulacao da glicemia e funcao cardiaca pela ativacao do eixo leptina-sistema melanocortina cerebral (Portuguese), Faculdade Atenas, Passos, MG - Brazil, Passos, MG - Brazil (online) | 03/2022 |
| State/Local Invited Seminars/Lectures, The CNS as an important target for improving glycemic control and cardiac function, UMMC-Department of Physiology and Biophysics Seminar Series, Jackson, MS | 11/2021 |
| Regional Invited Seminars/Lectures, Mechanisms of cardiac protection by the leptin-melanocortin system pathway in heart failure, Multi-COBRE Seminar Series, Online platform | 08/2021 |
| Regional Invited Seminars/Lectures, CNS mechanisms of cardiac protection in heart failure, Multi-COBRE Seminar Series, Online platform | 12/2020 |
| Invited Symposia, Leptin, cardiac function, and glucose homeostasis, State University of Londrina, PR - Brazil, Online Platform | 12/2020 |
| Platform Presentations, Cardiac protection by the leptin-brain melanocortin system in heart failure, VisualSonics Fujifilm Webinar Series, Online Platform | 11/2020 |
| State/Local Invited Seminars/Lectures, Metabolic and cardiac beneficial effects of activating the brain leptin-melanocortin system pathway, UMMC - Department of Physiology and Biophysics Seminar Series, Jackson, MS | 08/2020 |
| National and International Invited Seminars/Lectures, New CNS mechanisms for glycemic control and cardiac function, Internation Symposium in Medical Physiology, Ribeirao Prato, SP - Brazil | 08/2019 |
| State/Local Invited Seminars/Lectures, Control of glucose homeostasis and cardiac function by the leptin-melanocortin system, UMMC - Nephrology Division, Jackson, MS | 12/2018 |
| Invited Symposia, Control of blood glucose and cardiovascular function by leptin and melanocortin 4 receptors, Symposium Hypertension Research Exchange Program School of Dentistry, UNESP, SP - Brazil, Araraquara, SP - Brazil | 08/2017 |
| Invited Symposia, Papel do eixo leptina-sistema melanocortin cerebral na homeostase glicemica e no controle da função cardiovascular (Portuguese), UNIARA School of Medicine Annual Symposium, Araraquara, SP - Brazil | 04/2017 |
| State/Local Invited Seminars/Lectures, Controle central da glicemia e da função cardiovascular pelo eixo leptina-sistema melanocortina (Portuguese), USP-RP Department of Physiology University of Sao Paulo-Brazil, Ribeirao Preto, SP - Brazil | 10/2015 |
| State/Local Invited Seminars/Lectures, CNS regulation of glucose homeostasis and cardiovascular function by leptin, Tulane University - Physiology Department Seminar Series, New Orleans, LA | 07/2014 |
| State/Local Invited Seminars/Lectures, Neurohumoral control of glucose homeostasis and cardiovascular function by the leptin-melanocortin-4 receptor axis, UTHSC Medical School-Department of Integrative Biology and Pharmacology Seminar Series, Houston, TX | 02/2014 |
| National and International Invited Seminars/Lectures, Cardiovascular Biology of the Leptin System: Safety Implications, Safety Pharmacology Annual Meeting, Phoenix, AZ | 10/2012 |
| National and International Invited Seminars/Lectures, Brain mechanisms in obesity and hypertension., American Society of Hypertension Annual Meeting, New York, NY | 05/2012 |
| Poster Presentation, AT1 receptor antagonism but not mineralocorticoid receptor blockade lowers blood pressure in obese Zucker rats., FASEB, San Diego, CA. | 04/2012 |
| Poster Presentation, Ganglionic blockade does not impair the chronic CNS-mediated antidiabetic action of leptin in streptozotocin-induced diabetic rats., FASEB, San Diego, CA | 04/2012 |
| Scientific Presentations, Ganglionic blockade does not impair the chronic CNS-mediated antidiabetic action of leptin in streptozotocin-induced diabetic rats., FASEB, San Diego, CA | 04/2012 |
| Poster Presentation, Metabolic and appetite responses to fasting and refeeding in mice with SHP2 deletion in forebrain neurons., FASEB, San Diego, CA | 04/2012 |
| Poster Presentation, Differential control of appetite and cardiovascular function after rescue of melanocortin-4 receptors in proopiomelanocortin neurons., CHBPR, Orlando, FL | 09/2011 |
| Poster Presentation, Stat3 inactivation in POMC neurons attenuates leptin-induced elevation in arterial pressure., CHBPR, Orlando, FL. | 09/2011 |
| Poster Presentation, Cardiovascular and metabolic responses to chronic central MC3/4R antagonism in obese Zucker rats., FASEB, Washington, DC | 04/2011 |
| Poster Presentation, Cardiovascular and metabolic responses to thermoneutrality and cold ambient temperature in lean and obese leptin deficient mice., FASEB, Washington, DC | 04/2011 |
| National and International Invited Seminars/Lectures, Role of leptin in cardiovascular and kidney disease, AHA - Scientific Sessions, Chicago, IL, USA | 11/2010 |
| Invited Symposia, Neurohumoral control of glucose homeostasis and cardiovascualr function, ICB-USP and FAPESP/CNPq/CAPES, Sao Paulo, Brazil | 10/2010 |
| National and International Invited Seminars/Lectures, The role of central neural actions of leptin in regulation of glucose homeostasis in normal and diabetic states, FASEB Summer Conference, Saxtons River, Vermont, USA | 07/2010 |
| Poster Presentation, Chronic central nervous system MC3/4R activation exacerbates the cardiovascular responses to peripheral nitric oxide synthase inhibition., Experimental Biology Meeting., Anaheim, CA. | 04/2010 |
| Poster Presentation, Inhibition of soluble epoxide hydrolase reduces food intake and increases metabolic rate in mice fed high fat-high fructose diet., Experimental Biology Meeting, Anaheim, CA. | 04/2010 |
| Poster Presentation, Central NPY deficiency does not enhance the chronic actions of melanocortin 3 and 4 receptors (MC3/4R) activation on glucose homeostasis, appetite and cardiovascular function in diabetic mice., Experimental Biology Meeting, Anaheim, CA. | 04/2010 |
| Poster Presentation, Chronic CNS actions of adiponectin on appetite, metabolism and cardiovascular function., Experimental Biology Meeting, Anaheim, CA. | 04/2010 |
| Poster Presentation, Central NPY deficiency does not enhance the chronic actions of melanocortin 3 and 4 receptors (MC3/4R) activation on glucose homeostasis, appetite and cardiovascular function in diabetic mice, Experimental Biology, Anaheim, CA, USA | 04/2010 |
| Poster Presentation, Role of CNS IRS2 signaling in mediating the chronic effects of leptin on glucose regulation., Global Obesity Summit, Jackson, MS | 2010 |
| State/Local Invited Seminars/Lectures, Central mechanisms regulating glucose homeostasis., Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS. | 11/2009 |
| Poster Presentation, Central neuropeptide Y (NPY) deficiency does not enhance the dietary or cardiovascular responses to chronic activation of melanocortin 3 and 4 receptors (MC3/4R)., Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease., Chicago, IL. | 09/2009 |
| Poster Presentation, Consequences of prolonged obesity on cardiovascular, metabolic and respiratory functions in leptin-deficient and diet-induced obese mice., Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease., Chicago, IL. | 09/2009 |
| Poster Presentation, Divergent control of appetite, cardiovascular and metabolic functions by leptin in mice lacking leptin receptor in POMC neurons., Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease., Chicago, IL. | 09/2009 |
| State/Local Invited Seminars/Lectures, CNS control of glucose homeostasis., Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS | 07/2009 |
| Poster Presentation, Cardiovascular and metabolic responses to chronic central infusion of leptin in rats fed a high fat diet., Experimental Biology Meeting, New Orleans, LA. | 04/2009 |
| Poster Presentation, Cardiovascular and metabolic responses to chronic PYY infusion., Experimental Biology Meeting, New Orleans, LA. | 04/2009 |
| Poster Presentation, Cardiovascular function and metabolism in mice with Shp2 deletion in forebrain neurons., Experimental Biology Meeting., New Orleans, LA. | 04/2009 |
| National and International Invited Seminars/Lectures, Neurohumoral mechanisms of CNS control of glucose homeostasis., Department of Physiology of the Medical College of Georgia, Augusta, GA | 11/2008 |
| Scientific Presentations, Endogenous activity of the CNS melanocortin system contributes to the elevated arterial pressure in spontaneously hypertensive rats., Inter-American Society of Hypertension and the Consortium for Southeastern Hypertension Control., Miami, FL. | 04/2007 |
| Scientific Presentations, A functional melanocortin system is required for the CNS actions of leptin on peripheral glucose regulation and cardiovascular function., Experimental Biology Meeting., San Francisco, CA. | 04/2006 |
| Scientific Presentations, CNS actions of leptin play a major role in peripheral glucose regulation independent of adrenergic activation, Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease., Washington, DC. | 09/2005 |
Honors, Awards, and Recognition
| Medical Physiology Faculty - Evers Society Award for Basic Science Department of the Year, University of Mississippi Medical Center | 2023 |
| Distinction in Scholarship, Selection for APS Select, The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology for the article entitled "Impact of leptin deficiency compared with neuronal-specific leptin receptor deletion on cardiometabolic regulation", The American Physiological Society | 2019 |
| Vevo Travel Award - Hypertension Council of the American Heart Association, Fujifilm/VisualSonics | 2018 |
| Marcos Augusto Award, Centro Universitario Barao de Maua | 2017 |
| Distinction in Scholarship; Selection for APS select, The American Journal of Physiology-Endocrinology and Metabolism for the article entitled "Role of autonomic nervous system in chronic CNS-mediated antidiabetic action of leptin", The American Physiological Society | 2017 |
| Fellow of the American Heart Association, American Heart Association | 2012 |
| Excellence in Research Award - Bronze Level, University of Mississippi Medical Center | 2007 |
| New Investigator Award from CV Therapeutics, American Heart Association | 2005 |
| Research Recognition Award, The American Physiological Society | 2005 |
| Young Investigator Award, International Society of Hypertension | 2002 |
| MERCK New Investigator Award - Council for Hypertension of the American Heart Association, American Heart Association | 1999 |
| Young Investigator Award, International Society of Hypertension | 1998 |
Professional Membership and Service
| Frontiers in Physiology, Member, Editorial Board | 2019 - Present |
| Frontiers Endocrinology (Lausanne), Member, Editorial Board | 2018 - Present |
| American Heart Association, Fellow | 2012 - Present |
| American Heart Association - Hypertension Journal, Member, Editorial Board | 2011 - 2017 |
| Inter-American Society of Hypertension, Member | 2007 - Present |
| American Heart Association. Council for High Blood Pressure/Kidney Research, Member | 2005 - Present |
| American Physiological Society, Member | 2003 - Present |
Committee Service
| Doctoral Advisory Committee - Jordan Malette, Member | 2023 - Present |
| Swiss National Science Foundation Grant Review Committee, External Ad Hoc Grant Reviewer | 2023 - Present |
| Doctoral Advisory Committee - Umesh Bhattarai, Member | 2022 - Present |
| Doctoral Advisory Committee - Madison Newberry, Member | 2022 - Present |
| NIH - Therapeutic Development and Pre-Clinical Studies study section, Grant reviewer | 2022 - Present |
| American Heart Association - Vascular Biology and Blood Pressure Study Section, Member | 2022 - Present |
| Department of Physiology Faculty Search/Recruiting Committee, Member | 2022 - Present |
| Pilot Grants Review Committe - Cardiorenal and Metabolic Diseases Research Center COBRE, Member | 2019 - Present |
| Pilot Grants Review Committee - Mississippi Center for Clinical and Translational Research (MCCTR), Member | 2018 - Present |
| Czech National Science Foundation Grant Review Committee, External Ad Hoc Grant Reviewer | 2018 - Present |
| Faculty Recruiting Committee, Centro Universitario Barao de Maua, Ribeirao Preto - Brazil, Vice Chair | 2016 - 2017 |
| Medical School Faculty Senate Committee - Centro Universitario Barao de Maua, Ribeirao Preto - Brazil, Member | 2015 - 2017 |
| Undergraduate Research Nucleus Committee - Centro Universitario Barao de Maua, Ribeirao Preto - Brazil, Vice Chair | 2015 - 2017 |
| International Relations Committee - Centro Universitario Barao de Maua, Ribeirao Preto - Brazil, Steering Committee Member | 2015 - 2017 |
| International Society of Hypertension - Abstract Review Committee, Abstract Reviewer | 2014 - Present |
| Doctoral Advisory Committee - Charles A. Weeks, Member | 2013 - 2015 |
| Itramural Research Support Program (IRSP) Grant Review Committee, Grant Reviewer | 2013 - Present |
| Doctoral Advisory Committee - Fouad Zouein, Member | 2011 - 2013 |
| Doctoral Advisory Committee - Carlos Zgheib, Member | 2010 - 2012 |
| American Heart Association – Vascular Biology I Study Section, Member | 2009 - 2014 |
Community Service
| Mississippi Phun Week - Children's Museum, Instructor - the kidneys | 09/2021 - Present |
| American Heart Association (AHA) - Heart Walk, Volunteer | 11/2010 - 11/2014 |
| Hearts Against AIDS, Volunteer | 06/2008 - 07/2011 |
Other Service
| Journal American College of Cardiology (JACC) main journal | 08/2023 - Present |
| Frontiers in Pediatric journal | 08/2022 - Present |
| NIH Grant Review | 08/2022 - Present |
| Biology of Sex Differences journal | 06/2020 - Present |
| Journal American College of Cardiology (JACC)-Heart Failure journal | 03/2020 - Present |
| Frontiers in Endocrinology (Lausanne), Guest Editor | 11/2019 - Present |
| Frontiers in Physiology | 08/2019 - Present |
| Physiological Reports journal | 07/2019 - Present |
| Frontiers in Endocrinology (Lausanne) | 05/2019 - Present |
| Current Drug Targets journal | 03/2019 - Present |
| Winter Research Program | 10/2018 - Present |
| Journal of the American Heart Association (JAHA) | 05/2018 - Present |
| CORE supervision, Sub-CORE leader of Imaging Core | 03/2018 - Present |
| Journal Endocrinology (Lausanne) | 09/2017 - Present |
| American Journal of Physiology-Circulatory and Cardiovascular Physiology | 07/2016 - Present |
| PlosONE journal | 06/2014 - Present |
| Circulation Research journal | 06/2014 - Present |
| Journal of Pharmacological and Toxicological Methods | 06/2012 - Present |
| Hypertension journal | 09/2011 - 12/2017 |
| Diabetes journal | 06/2010 - Present |
| Neuropeptides journal | 10/2009 - Present |
| Life Sciences journal | 09/2009 - Present |
| Journal of Molecular Endocrinology | 09/2009 - Present |
| Acta Diabetologica journal | 10/2008 - Present |
| Chaired Session, Chaired Scientific Session | 10/2008 - 10/2008 |
| Future Medicine journal | 09/2008 - Present |
| American Journal of Physiology-Endocrine Physiology | 06/2008 - Present |
| American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | 05/2007 - Present |
| Diabetes and Metabolic Syndrome journal | 03/2007 - Present |
| Journal of Hypertension | 08/2006 - Present |
| Peptides journal | 09/2005 - Present |
| American Journal of Hypertension | 06/2005 - Present |
| Brazilian Journal of Medical and Biological Research | 06/2005 - Present |
| Brain Research Bulletin journal | 06/2005 - Present |
| European Journal of Internal Medicine | 04/2005 - Present |
| Hypertension journal | 03/2004 - Present |
Teaching Experience
| SOM613, Medicine, Course, Lecturer, Cardiovascular System | Spring 2024 - 2024 |
| Physio727, Graduate, Course, Course Presenter, Physiological Applications of Molecular Biology | Fall 2023-2024 |
| Physio715, Graduate, Course, Lecturer, Advanced Endocrinology | Fall 2023 |
| Physio611, Medicine, Course, Course Presenter, Medical Physiology (Cardiovascular Physiology section) | Annual 2022-2023 |
| Physio611, Medicine, Small Group, Facilitator, Medical Physiology (Renal Physiology PBL) | Annual 2022-2023 |
| Physio715, Graduate, Course, Lecturer, Advanced Endocrinology | Fall 2022 |
| Physio611, Medicine, Small Group, Facilitator, Medical Physiology (Renal Physiology PBL) | Annual 2021-2022 |
| Physio715, Graduate, Course, Lecturer, Advanced Endocrinology | Fall 2021 |
| Physio611, Medicine, Small Group, Facilitator, Medical Physiology (Renal Physiology PBL) | Annual 2020-2021 |
| Physio715, Graduate, Course, Lecturer, Advanced Endocrinology | Fall 2020 |
| Physio715, Graduate, Course, Lecturer, Advanced Endocrinology | Fall 2019 |
| Physio611, Medicine, Small Group, Facilitator, Medical Physiology (Renal Physiology PBL) | Annual 2018-2019 |
| Medicine, Course, Course Director, Winter Research Program | Winter 2018 |
| Physio611, Medicine, Small Group, Facilitator, Medical Physiology (Renal Physiology PBL) | Annual 2017-2018 |
| Physio611, Medicine, Course, Course Presenter, Medical Physiology (Neurophysiology) | Annual 2013/2014 |
| Physio611, Medicine, Course, Course Presenter, Medical Physiology (Neurophysiology) | Annual 2012-2013 |
| Physio611, Medicine, Course, Course Presenter, Medical Physiology (Neurophysiology) | Annual 2011-2012 |
Directed Student Learning
| Doctoral Advisory Committee Member, Yet to be determined Advised: Jordan Malette | 2023 - Present |
| Research Advisor, Advised: Micaela Espinoza | 2023 - 2023 |
| Research Advisor, Advised: John Nall | 2023 - 2023 |
| Master's Thesis Committee Member, Low sodium consumption, lipogenesis, inflammation and insulin resistance in visceral adipose tissue and their regulation by aerobic exercise Advised: Vanessa Del Bianco | 2023 - Present |
| Dissertation Defense Committee Member, Protective mechanisms of mesenchymal stem cells in renal ischemia-reperfusion injury Advised: Beatriz Correa | 2023 - 2023 |
| Research Advisor, Advised: Odecio Tosta | 2022 - 2023 |
| Supervised Research, Advised: Marcela Cruz | 2022 - 2023 |
| Research Advisor, Advised: Marilia Mouro | 2022 - 2023 |
| Doctoral Advisory Committee Member, Yet to be determined Advised: Umesh Batharai | 2022 - Present |
| Doctoral Advisory Committee Member, Not yet determined Advised: Madison Newberry | 2022 - Present |
| Research Advisor, Advised: Kari Oppedal | 2022 - 2022 |
| Supervised Research, Advised: Alexandra Garriga | 2022 - 2022 |
| Supervised Research, Advised: Benjamin Nelson | 2021 - Present |
| Doctoral Advisory Committee Member, Protective mechanisms of mesenchymal stem cells in renal ischemia-reperfusion injury Advised: Beatriz Correa | 2021 - 2023 |
| Master's Thesis Committee Member, Impact of sodium consumption and mesenchymal stem cells treatment in rats submitted to renal ischemia reperfusion. Advised: Beatriz Correa | 2020 - 2020 |
| Research Advisor, Advised: Gisele Borges | 2019 - 2020 |
| Supervised Research, Advised: Rodrigo Gulke | 2019 - 2020 |
| Research Advisor, Advised: Gabriela Mega | 2019 - 2019 |
| Research Advisor, Advised: Mateus Salgado | 2018 - 2019 |
| Research Advisor, Advised: Cary Roy | 2018 - 2018 |
| Dissertation Defense Committee Member, Cardiovascular responses to carotid body electrical stimulation in awake normotensive and hypertensive rats Advised: Gean Souza | 2016 - 2016 |
| Research Advisor, Advised: Tamires Guida | 2016 - 2017 |
| Research Advisor, Advised: Drieli Rodrigues | 2016 - 2017 |
| Doctoral Advisory Committee Member, Cardiovascular responses to carotid body electrical stimulation in awake normotensive and hypertensive rats Advised: Gean Souza | 2015 - 2016 |
| Dissertation Defense Committee Member, Relationship between chemistry, surface properties, and hepatocyte spheroid culture performance of charged elastin-like-polypeptide coatings. Advised: Charles Weeks | 2015 - 2015 |
| Research Advisor, Advised: Mark Pinkerton | 2014 - 2014 |
| Supervised Research, Advised: Jarret Morgan | 2014 - 2014 |
| Research Advisor, Advised: Sumner Abraham | 2014 - 2014 |
| Supervised Research, Advised: Sarah Mortaja | 2014 - 2014 |
| Doctoral Advisory Committee Member, Relationship between chemistry, surface properties, and hepatocyte spheroid culture performance of charged elastin-like-polypeptide coatings. Advised: Charles Weeks | 2013 - 2015 |
| Dissertation Defense Committee Member, Importance of STAT3 in hypertension-induced remodeling of the heart Advised: Fouad Zouein | 2013 - 2013 |
| Supervised Research, Advised: Sumner Abraham | 2013 - 2013 |
| Research Advisor, Advised: John Freeman | 2013 - 2013 |
| Dissertation Defense Committee Member, Regulation of inflammatory JAK-STAT signaling: implications for cardiac repair and remodeling Advised: Carlos Zgheib | 2012 - 2012 |
| Research Advisor, Advised: Ammar Alsheik | 2012 - 2012 |
| Doctoral Advisory Committee Member, Importance of STAT3 in hypertension-induced remodeling of the heart Advised: Fouad Zouein | 2011 - 2013 |
| Research Advisor, Advised: Ahmad Adi | 2011 - 2011 |
| Doctoral Advisory Committee Member, Regulation of inflammatory JAK-STAT signaling: implications for cardiac repair and remodeling Advised: Carlos Zgheib | 2010 - 2012 |
| Research Advisor, Advised: John Freeman | 2010 - 2010 |
| Supervised Research, Impact of obesity on renal 11-beta hydroxysteroid dehydrogenase expression Advised: Wendy Case | 2007 - 2008 |
| Research Advisor, Advised: Paul Brown | 2006 - 2006 |
| Research Advisor, Advised: James Clark | 2005 - 2005 |
Fellows supervised
| Physiology, Co-research advisor, 1 fellows supervised | 08/2023 - Present |
| Physiology, Post-Doc Advisor, 1 fellows supervised | 01/2020 - 07/2022 |
| Physiology, Research Advisor, 1 fellows supervised | 02/2010 - 09/2011 |
| Physiology, Co-research advisor, 1 fellows supervised | 09/2009 - 05/2011 |
| Physiology, Research Advisor, 1 fellows supervised | 05/2006 - 06/2008 |
| Physiology, Co-research advisor, 1 fellows supervised | 12/2003 - 04/2005 |