Denise C. Cornelius, PhD

Denise C. Cornelius, PhD

Associate Professor

Department:
SOM-Pharmacology/Toxicology

Email:
dcornelius@umc.edu

Work Phone:
(601) 815-1551

Biography

Dr. Cornelius is an Associate Professor and the Director of Pre-Clinical Research in the Department of Emergency Medicine at the University of Mississippi Medical Center.

Dr. Cornelius is currently a member of Frontiers in Physiology and BMC Pregnancy and Childbirth. She also serves as a reviewer for a number of journals including Hypertension, American Journal of Physiology: Regulatory and Integrative Physiology, Ciculation, and Journal of Thoracic Disease. She has published over 60 peer reviewed manuscripts, book chapters, and editorials in leading journals for the field of hypertension research and cardiovascular physiology.

Dr. Cornelius serves in multiple leadership capacities. She currently serves on the AMericna Heart Association's Council on Hypertension Leadership Committee and the American Physiological Society's Financial Committee and. She recently began her term as a standing member of the NIH Systemic Injury from Environmental Exposure Study section and as Chair of the AHA Fellowship Grant Reveiw Panel. At the institutional level, Dr. Cornelius serves as the Vice Chair of the Institutional Biosafety Committee, a member of the Research Compliance Committee and Co-Director of the MCCTR Mentor Academy. Dr. Cornelius also lectures in the medical, dental, and graduate school courses, and serves as a research mentor for trainees at all levels.

Dr. Cornelius has received several awards throughout her career including the UNCF-Merck Graduate Dissertation Science Research Fellowship, the American Physiological Society Minority Travel Award, the American Physiological Society Water and Electrolyte Homeostasis Postdoctoral Research with Distinction Award, and the American Heart Association’s Council on Hypertension New Investigator’s Award. She was selected as UMMC's Early Career Investigator (2019), the WEH Section New Investigator of the Year (2020) and the GWIMS Early Career Rising Star (2020).
Dr. Cornelius’s laboratory has research focus in two major areas. The first is related to understanding how immune system activation mechanistically promotes the pathogenesis of hypertension and intrauterine growth restriction during pregnancy. Using multiple experimental models of preeclampsia, Dr. Cornelius’s lab investigates the renal and vascular mechanisms during preeclampsia and how they are influenced by inflammatory and cytotoxic immune cells and mediators. The second is related to understanding mechanisms that lead to the development of multi-organ injury during sepsis. Patients with sepsis have increased platelet activation are prone to develop multi-organ failure and have poor clinical outcomes. Dr. Cornelius’s laboratory uses a modified cecal ligation and puncture model that mimics characteristics of sepsis to investigate an important role for activated platelets in the development of multi-organ injury in sepsis.

Education

University of Mississippi Medical Center, Postdoctoral Research Fellow, Physiology/Pharmacology2015
University of Mississippi Medical Center, PhD, Microbiology/Immunology2012
University of Mississippi Medical Center, MS, Biomedical Sciences2010
Howard University, BS, Biology2006

Specialty Certification Licensure

Certification, Data Management in Clinical Research07/2023 - Present

Current Positions

Associate Professor, School of Medicine, Department of Pharmacology / Toxicology09/2022 - Present
Associate Professor, School of Medicine, Department of Emergency Medicine09/2022 - Present
Director of Immuno-Assay Core, School of Medicine, Department of Pharmacology / Toxicology09/2022 - Present
Director of Pre-Clinical Research, School of Medicine, Department of Emergency Medicine07/2015 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Emergency Medicine07/2021 - 09/2021
Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology07/2021 - 09/2022
Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Emergency Medicine09/2017 - 06/2021
Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology09/2017 - 06/2021
Instructor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology07/2015 - 08/2017
Instructor, University of Mississippi Medical Center, School of Medicine, Department of Emergency Medicine07/2015 - 08/2017

Sponsored Program Funding

Extramural, Hypertension, Inflammation, and Vascular Function, NIH/National Heart Lung and Blood Institute05/2020 - 03/2025
Extramural, A Role for Natural Killer Cells in the Development of Intrauterine Growth Restriction
and Hypertension During Pregnancy, NIH/National Heart Lung and Blood Institute
04/2020 - 03/2022
Extramural, Mechanisms Linking Platelet Activation with Sepsis Pathophysiology, NIH/National Institute of General Medical Sciences11/2017 - 11/2019
Extramural, Hypertension and Inflammation, NIH/National Heart Lung and Blood Institute09/2016 - 08/2021
Extramural, Natural killers cells as mediators of hypertension in response to placental ischemia, American Heart Association01/2016 - 12/2020
Extramural, Hypertension, the kidney, and inflammation, NIH/National Heart Lung Blood Institute12/2014 - 11/2015
Extramural, Population Genetics, characterization of virulence factors, and epidemiology of Trichomonas vaginalis, United Negro College Fund- Merck Science Initiative10/2010 - 04/2012

Publications

Journal Article

Cornelius DC, McCalmon M, Tharp J, Puskarich M, Jones AE Fluid Resuscitation in Animal Models of Sepsis: A Comprehensive Review of the Current State of Knowledge Archives of Emergency Medicine and Critical Care. 2016; 1:10022016

Book Chapter

Cornelius DC Sex Differences in Cardiovascular Physiology and Pathophysiology Elsevier, Cambridge, 20192019
Meade JC, Cornelius DC Sexually Transmitted Infections in the Tropics, Current Topics in Tropical Medicine InTech, Rijeka, 20122012

Presentations

Platform Presentations, IL-33 Supplementation Improves Vascular Function and Maternal Hypertension in Response to Placental Ischemia, American Heart Association Council on Hypertension Scientific Sessions, San Diego, CA09/2022
National and International Invited Seminars/Lectures, Investigations into Mechanisms of Sepsis-Induced Organ Injury, Washington University School of Medicine in St. Louis Department of Emergency Medicine, St. Louis, MO05/2022
Platform Presentations, NLRP3 inhibition improves maternal blood pressure, inflammation, and vascular function during placental ischemia, Experimental Biology, Philadelphia, PA04/2022
Platform Presentations, IL-25 supplementation induces M2 macrophage polarization, reduces blood pressure, and improves fetal weight in placental ischemic rats, Experimental Biology, Philadelphia, PA04/2022
Poster Presentation, Treatment with rapamycin reduces progressive proteinuria while inducing hyperglycemia in obese Dahl salt-sensitive leptin receptor mutant rats prior to puberty, Experimental Biology, Philadelphia, PA04/2022
Poster Presentation, Decreasing insulin resistance reduces early progressive proteinuria by decreasing renal hyperfiltration and inflammation in obese Dahl salt-sensitive rats, Experimental Biology, Philadelphia, PA04/2022
Poster Presentation, NLRP3 inhibition improves maternal blood pressure, inflammation, and vascular function during placental ischemia, Experimental Biology, Philadephia, PA04/2022
Poster Presentation, IL-25 supplementation induces M2 macrophage polarization, reduces blood pressure, and improves fetal weight in placental ischemic rats, Experimental Biology, Philadelphia, PA04/2022
State/Local Invited Seminars/Lectures, Black in Biology Panel, Jackson State University Biology Society, Jackson, MS02/2022
National and International Invited Seminars/Lectures, Innate-Adaptive Immune Crosstalk in Pathophysiology of Preeclampsia, University of Michigan Samuel and Jean Frankel Cardiovascular Center, Virtual12/2021
National and International Invited Seminars/Lectures, Characterizing Immune Mechanisms of Preeclampsia Pathophysiology, Zooming in on Preeclampsia, Virtual12/2021
Poster Presentation, Inhibition of NLRP3 improves PE pathophysiology in Response to Placental Ischemia, Annual Biomedical Research Conference for Minority Students, Virtual11/2021
Poster Presentation, NLRP3 inhibition improves PE pathophysiology in Response to Placental Ischemia, Annual Biomedical Research Conference for Minority Students, Virtual11/2021
National and International Invited Seminars/Lectures, Sex Differences in Response to Sepsis, American Physiological Society’s New Trends in Sex and Gender Medicine Conference, virtual10/2021
Poster Presentation, Progesterone induced blocking factor decreases hypertension mitochondrial dysfunction and reactive oxygen species in response to elevated sFlt-1 during pregnancy, Virtual09/2021
Platform Presentations, IL-17 causes hypertension, reduced fetal weight, and natural killer cell activation in the absence of T cells, AHA Council on Hypertension Scientific Sessions, Virtual09/2021
Platform Presentations, Esomeptrazole improves blood pressure, intrauterine growth restriction, inflammation, and vascular function during placental ischemia through inhibition of NLRP3, AHA Council on Hypertension Scientific Sessions, Virtual09/2021
Platform Presentations, Inhibiting Stimulatory Dendritic Cells Reduces Early Progressive Proteinuria In Obese Dahl Saltsensitive Rats, AHA Council on Hypertension Scientific Sessions, Virtual09/2021
Poster Presentation, Sex differences in macrophage polarization during the early progression of renal disease in obese Dahl Salt-Sensitive rats prior to puberty, Experimental Biology, Virtual04/2021
Poster Presentation, Progesterone and PIBF: new insights into treatment options for preeclampsia, Experimental Biology, Virtual04/2021
Poster Presentation, Elevations in arterial pressure is associated with increases in plasma angiotensin II and angiotensin 1-9 in obese SS rats prior to puberty, Experimental Biology, Virtual04/2021
Platform Presentations, IL-17 Causes hypertension and multi-organ dysfunction which is attenuated with blockade of agonistic autoantibodies to the angiotensin II type I (AT1-AA) receptor during pregnancy, Experimental Biology, Virtual04/2021
Platform Presentations, Administration of MIP3-alpha neutralization antibody reduces the renal infiltration of dendritic cells and Th17s and attenuates progressive proteinuria in obese Dahl salt-sensitive rats, Experimental Biology, Virtual04/2021
Platform Presentations, NLRP3 plays a causative role in vascular and renal dysfunction in hypertension in placental ischemic pregnancy, Experimental Biology, Virtual04/2021
Platform Presentations, Neutralization of Natural Killer Cell associated cytokines improves vascular function and reduced blood pressure in placental ischemic rats, Experimental Biology, Virtual04/2021
Platform Presentations, AT1-AAs cause vascular endothelial mitochondrial oxidative stress associated with Preeclampsia, Experimental Biology, Virtual04/2021
Platform Presentations, Placental Ischemia Stimulated Natural Killer Cells Play a Direct Role in Causing Hypertension and Intrauterine Growth Restriction in Pregnant Rats, Experimental Biology, Virtual04/2021
State/Local Invited Seminars/Lectures, Black in Biology Panel, Jackson State University Biological Society, Jackson, MS02/2021
Platform Presentations, IL-17 stimulates B cells to secrete AT1-AA in hypertension and multi-organ tissue dysfunction during pregnancy, Society of Maternal Fetal Medicine Annual Meeting, Virtual01/2021
Regional Invited Seminars/Lectures, Maintaining Maternal Balance: Adaptive-Innate Crosstalk in Preeclampsia, Meharry Medical College, Nashville, TN10/2020
Poster Presentation, Treatment with IL-25 slows the early progression of proteinuria in obese Dahl Salt-Sensitive rats, American Heart Association Council on Hypertension Fall Specialty Conference, Virtual09/2020
Poster Presentation, Placental ischemia-stimulated natural killer cells contribute to hypertension, vascular dysfunction, and intrauterine growth restriction in pregnant rats, American Heart Association Council on Hypertension Fall Specialty Conference, Virtual09/2020
Poster Presentation, Mitochondrial dysfunction And natural killer cell activation stimulated by IL-17 signaling from Th17 cells in response to placental ischemia during pregnancy, American Heart Association Council on Hypertension Fall Specialty Conference, Virtual09/2020
National and International Invited Seminars/Lectures, Restarting a Lab or Research Project During a Pandemic, American Heart Association, Online Webinar07/2020
Poster Presentation, Placental Ischemia Stimulated Natural Killer Cells Play a Direct Role in Causing Hypertension and Intrauterine Growth Restriction in Pregnant Rats, Experimental Biology, Virtual04/2020
Poster Presentation, IL-17 signaling mediates cytolytic natural killer cell activation in placental-ischemic rats., Experimental Biology, Virtual04/2020
Poster Presentation, Progesterone induced blocking factor improves blood pressure, mitochondrial dysfunction, and reactive oxygen species in response to sFlt-1 induced hypertension during pregnancy, Experimental Biology, Virtual04/2020
Poster Presentation, The early progression of renal injury in obese Dahl Salt-Sensitive rats is associated with increased M2 macrophage infiltration, `Experimental Biology, Virtual04/2020
Platform Presentations, The role of NLRP3 inflammasome in sepsis-induced multi-organ injury., Mississippi Academy of Science Annual Meeting, Biloxi, MS02/2020
Poster Presentation, IL-17 signaling mediates cytolytic natural killer cell activation in response to placental ischemia, Council on Hypertension Scientific Sessions, New Orleans, LA09/2019
Platform Presentations, Cytolytic natural killer cells play a direct role in causing hypertension and intrauterine growth restriction in pregnant rats, Council on Hypertension Scientific Sessions, New Orleans, LA09/2019
Poster Presentation, Inhibition of NLRP3 activation attenuates platelet activation and decreases multi-organ injury in response to abdominal sepsis, 42nd Annual Conference on Shock 2019, Coronado, CA06/2019
Poster Presentation, Suppression of TH17 cells blunts preeclampsia-associated cytolytic natural killer cells during pregnancy, Experimental Biology, Orlando, FL04/2019
Poster Presentation, Interleukin-4 supplementation improves the pro-inflammatory ratios, autoantibodies, and blood pressure in response to placental ischemia, Experimental Biology, Orlando, FL04/2019
Poster Presentation, Depletion of macrophages with clodronate partially reduces the progression of renal injury in obese Dahl salt-sensitive rats during prepubertal obesity, Experimental Biology, Orlando, FL04/2019
Platform Presentations, Platelet inhibition prevents NLRP3 inflammasome activation and sepsis-induced multi-organ injury, 48th Critical Care Congress, San Diego, CA02/2019
Platform Presentations, Etanercept improves Natural Killer Cell activation and hypertension in a preclinical rat model of Pre-eclampsia, Society for Maternal Fetal Medicine 2019, Las Vegas, NV02/2019
Poster Presentation, Progesterone induced blocking factor improves clinical characteristics of preeclampsia in RUPP rats, Council on Hypertension Scientific Sessions, Chicago, IL09/2018
Poster Presentation, Early renal hyperfiltration in obese Dahl salt-sensitive leptin receptor mutant rats is associated with glomerular leukocyte extravasation and renal disease, Council on Hypertension Scientific Sessions, Chicago, IL09/2018
Platform Presentations, Interleukin-17 mediates hypertension, intrauterine growth restriction, cytolytic natural killer Cells and Vascular Dysfunction in Pregnant Rats, Council on Hypertension Scientific Sessions, Chicago, IL09/2018
Poster Presentation, Stimulation of NLRP3 inflammasome assembly in activated platelets in response to abdominal sepsis, 41st Annual Meeting on Shock, Scottsdale, AZ06/2018
Platform Presentations, Phosphatidylserine expressing platelet microparticles predict sepsis mortality and correlates with thrombocytopenia, Society for Academic Emergency Medicine Annual Meeting, Indianapolis, IN05/2018
Platform Presentations, Sex differences in the development of renal injury in obese Dahl salt-sensitive leptin receptor mutant rants during prepubertal obesity, Experimental Biology, San Diego, CA04/2018
Platform Presentations, The role of mitochondrial oxidative stress in the pathophysiology of preeclampsia, Experimental Biology, San Diego, CA04/2018
Poster Presentation, Role of cerebral vascular dysfunction in Alzheimer-like cognitive deficits in diabetic T2DN rats, Experimental Biology, San Diego, CA04/2018
Poster Presentation, The role of interleukin-2 (IL-2) in Natural Killer Cell (NK) activation and hypertension in a preclinical rat model of preeclampsia, Experimental Biology, San Diego, CA04/2018
Poster Presentation, Sex differences in the development of renal injury in obese Dahl salt-sensitive leptin receptor mutant rants during prepubertal obesity, Experimental Biology, San Diego, CA04/2018
Poster Presentation, Progesterone induced blocking factor improves fetal growth restriction possibly by reducing inflammation and placental cytolytic NK cells in response to placental ischemia during pregnancy, Experimental Biology, San Diego, CA04/2018
Poster Presentation, The role of mitochondrial oxidative stress in the pathophysiology of preeclampsia, Experimental Biology, San Diego, CA04/2018
Poster Presentation, Placental ischemia stimulated TH17 cells induce preeclampsia associated cytolytic natural killer cells during pregnancy, Experimental Biology, San Diego, CA04/2018
Poster Presentation, The potential neuroprotective role of 20-HETE in association with its receptor GPR75 expression in hypertension, Eicosanoid Research Association, Inc, Baltimore, MD03/2018
Poster Presentation, Platelet activation is associated with pulmonary edema and renal injury in a rat model of polymicrobial sepsis., Council on Hypertension, San Francisco, CA09/2017
Poster Presentation, Placental ischemia-stimulated TH17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy., Council on Hypertension, San Francisco, CA09/2017
Poster Presentation, Circulating factors in response to placental ischemia cause vascular endothelial mitochondrial oxidative stress, Council on Hypertension Scientific Sessions, San Francisco, CA09/2017
Poster Presentation, Interleukin-4 supplementation improves chronic inflammation and hypertension in response to placental ischemia during pregnancy, Council on Hypertension Scientific Sessions, San Francisco, CA09/2017
Poster Presentation, Preeclamptic placental CD4+ T cells cause preeclamptic like features in normal pregnant nude athymic rats, Council on Hypertension Scientific Sessions, San Francisco, CA09/2017
Poster Presentation, Natural killer cells contribute to placental mitochondrial dysfunction in response to placental ischemia in reduced uterine perfusion pressure (RUPP) rat model of preeclampsia, APS Conference: Physiological Bioenergetics: Mitochondria from Bench to Bedside, San Diego, CA08/2017
Poster Presentation, Natural Killer Cells Stimulated in Response to Placental Ischemia Mediate Hypertension, Intrauterine Growth Restriction, and Inflammation during Pregnancy, Experimental Biology 2017, Chicago, IL04/2017
Platform Presentations, Natural Killer Cells Stimulated in Response to Placental Ischemia mediate Hypertension, Intrauterine Growth Restriction, and Inflammation during Pregnancy, Experimental Biology, Chicago, IL04/2017
Platform Presentations, Natural Killer Cells Stimulated in Response to Placental Ischemia Mediate Hypertension, Intrauterine Growth Restriction, and Inflammation during Pregnancy, Experimental Biology 2017, Chicago, IL04/2017
Poster Presentation, 17-hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing inflammation and placental cytolytic NK cells in response to placental ischemia during pregnancy, Experimental Biology, Chicago, IL04/2017
Poster Presentation, Inhibition of Angiotensin II Type 1 Receptor Agonistic Autoantibody binding Improves Maternal Outcomes in Rats with Placental Ischemia, Experimental Biology, Chicago, IL04/2017
Poster Presentation, Role of Natural Killer Cells as Mediators of Mitochondrial Dysfunction Induced by Placental Ischemia in the Reduced Uterine Perfusion Pressure (RUPP) Rat Model of Preeclampsia, Experimental Biology, Chicago, IL04/2017
Platform Presentations, Role of Natural Killer Cells as Mediators of Mitochondrial Dysfunction Induced by Placental Ischemia in the Reduced Uterine Perfusion Pressure (RUPP) Rat Model of Preeclampsia, Experimental Biology, Chicago, IL04/2017
Platform Presentations, Investigation of platelet microparticle (PMP) concentrations in patients with infectious (septic) shock as a potential indicator of prognosis, UMMC, Jackson, MS04/2017
Poster Presentation, A role Natural Killer cells in the pathophysiology of preeclampsia, Society for Maternal Fetal Medicine, Las Vegas, NV01/2017
Platform Presentations, NK cells play an important role in placental ischemia induced mitochondrial dysfunction in Reduced Uterine Perfusion Pressure (RUPP) rats, Pharmacology, London, UK11/2016
Platform Presentations, 17-hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing sFlt-1 and placental cytolytic NK cells in the Reduced Uterine Perfusion Pressure (RUPP) rat model of preeclampsia, International Society for the Study of Hypertension in Pregnancy, Sao, Paulo, Brazil10/2016
Platform Presentations, Depletion of natural killer cells activated in response to placental ischemia improves hypertension and IUGR during pregnancy, American Heart Association Council on Hypertension, Orlando, FL09/2016
Platform Presentations, 17-hydroxyprogesterone caproate improves and placental cytolytic NK cells in response to placental ischemia during pregnancy, Council on Hypertension Scientific Sessions, Orlando, FL09/2016
Platform Presentations, Metabolic Syndrome and the Pathway of Drug Development From Bench to Bedside, Experimental Biology, San Diego, CA04/2016
State/Local Invited Seminars/Lectures, Her Scientific Methods and Madness, Mississippi EPSCoR Program, Tougaloo College01/2016
Poster Presentation, Vitamin D Supplementation Inhibits Blood Pressure and Uterine Artery Resistance Induced by Autoantibodies to the AT1 Receptor, American Physiological Society Conference on Cardiovascular, Renal, and Metabolic Diseases: Physiology and Gender, Annapolis, MD11/2015
Platform Presentations, A role for IL-17 to activate cytolytic natural killer cells in response to placental ischemia, American Heart Association Council on Hypertension, Washington, DC09/2015
Platform Presentations, Early administration of 17-hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing sFLT-1 and placental cytolytic NK cells in response to placental ischemia during pregnancy, Council on Hypertension Scientific Sessions, Washington, DC09/2015
Poster Presentation, Inhibition of AT1-AAs by direct binding reduces blood pressure and natural killer cell activation in response to placental ischemia of pregnancy; emphasizing the importance of novel drug development in the treatment of preeclampsia, Council on Hypertension Scientific Sessions, Washington, DC09/2015
Poster Presentation, T Cell-Dependent B cell Activation Mediates Pathophysiology in Response to CD4+ T Cells from reduced Uterine Perfusion Pregnant Rats, Federation of American Societies of Experimental Biology, Boston, MA03/2015
Poster Presentation, Early administration of 17-hydroxyprogesterone caproate to reduced uterine perfusion pressure (RUPP) rat model of preeclampsia improves inflammation, uterine artery vasoconstriction and blood pressure during pregnancy, Experimental Biology, Boston, MA03/2015
Poster Presentation, Agonistic autoantibodies to the angiotensin II type I receptor enhance ANGII binding on vascular endothelial cells, Experimental Biology, Boston, MA03/2015
Platform Presentations, Placental Ischemia-Induced TH17 Cells Mediate the Pathophysiology Associated with Preeclampsia, Federation of American Societies for Experimental Biology, Boston, MA03/2015
Poster Presentation, Placental Ischemia-Induced TH17 Cells Mediate the Pathophysiology Associated with Preeclampsia, Federation of American Societies for Experimental Biology, Boston, MA03/2015
Platform Presentations, Agonistic autoantibodies to the angiotensin II type I receptor enhance ANGII binding on vascular endothelial cells, Experimental Biology, Boston, MA03/2015
Platform Presentations, A Role for TH17 cells and IL-17 in Mediating the Pathophysiology Associated with Preeclampsia, the International Society for the Study of Hypertension in Pregnancy, New Orleans, LA10/2014
Platform Presentations, Pregnant Nude-Athymic Rats Experience Preeclampsia-Like Pathophysiology When Exposed to CD4+ T Cells isolated from preeclamptic Women, International Society for the Study of Hypertension in Pregnancy, New Orleans, LA10/2014
Platform Presentations, Treatment with Vitamin D attenuates blood pressure and immune activation in a preeclamptic rat model, International Society for the Study of Hypertension in Pregnancy, New Orleans, LA10/2014
Platform Presentations, 17-hydroxyprogesterone caproate attenuates hypertension and uterine artery resistance in response to reduced uterine perfusion pressure in (RUPP) in pregnant rats, International Society for the Study of Hypertension in Pregnancy, New Orleans, LA10/2014
Platform Presentations, T cell-dependent B cell activation plays a role in mediating hypertension and pathophysiology in response to CD4+ T cell from reduced uterine perfusion pressure pregnant rats, American Heart Association High Blood Pressure Council, San Francisco, CA09/2014
Poster Presentation, Vitamin D supplementation reduces CD4+ T cells, blood pressure and autoantibodies to the AT1 receptor (AT1-AA) in a rat model of preeclampsia, Council on Hypertension Scientific Sessions, San Francisco, CA09/2014
Poster Presentation, Proliferation of endogenous T-reg cells improves the pathophysiology associated with placental ischemia of pregnancy, High Blood Pressure Council Scientific Sessions, San Francisco, CA09/2014
Poster Presentation, CD4+ T cells isolated from preeclamptic women produce a preeclampsia-like phenotype in nude-athymic rats, High Blood Pressure Council Scientific Sessions, San Francisco, CA09/2014
Platform Presentations, Progesterone supplementation improves blood pressure and uterine artery resistance in response to placental ischemia during pregnancy, High Blood Pressure Council Scientific Sessions, San Francisco, CA09/2014
Platform Presentations, Normal pregnant T Regs inhibit pathophysiology associated with hypertension in response to Reduced Uterine Perfusion Pressure (RUPP) in pregnant rats, Federation of American Societies of Experimental Biology, San Diego, CA04/2014
Poster Presentation, Normal pregnant T Regs inhibit pathophysiology associated with hypertension in response to Reduced Uterine Perfusion Pressure (RUPP) in pregnant rats, Federation of American Societies of Experimental Biology, San Diego, CA04/2014
Poster Presentation, IL-10 supplementation suppressed hypertension and inflammation in response to placental ischemia during pregnancy, Experimental Biology, San Diego, CA04/2014
Platform Presentations, IL-10 supplementation suppressed hypertension and inflammation in response to placental ischemia during pregnancy, Experimental Biology, San Diego, CA04/2014
Poster Presentation, Specific Inhibition of AT1-AAs by direct binding improves maternal and fetal outcome in response to placental ischemia during pregnancy; emphasizing the importance of novel drug development in the treatment of preeclampsia, Experimental Biology, San Diego, CA04/2014
Poster Presentation, Oxidative stress signaling in response to CD4+T cells stimulated via placental ischemia plays an important role in hypertension during preeclampsia, Experimental Biology, San Diego, CA04/2014
Poster Presentation, Inhibition of AT1-AAs by interrupting lymphocyte communication or by direct binding reduces blood pressure in response to placental ischemia of pregnancy; emphasizing the importance of novel drug development in the treatment of preeclampsia, Society for Maternal Fetal Medicine, New Orleans, LA02/2014
Platform Presentations, Reduced uterine perfusion pressure T-helper 17 cells cause hypertension and IUGR during pregnancy, American Heart Association Council for High Blood Pressure Research, New Orleans, LA09/2013
Platform Presentations, Progesterone supplementation attenuates hypertension and AT1-AA in response to elevated IL-6 during pregnancy, American Heart Association Council on Hypertension Scientific Sessions, New Orleans09/2013
Poster Presentation, Blunting circulating TH17 cells decreases hypertension and oxidative stress in response to placental Ischemia, Federation of American Societies of Experimental Biology, Boston, MA04/2013
Poster Presentation, Infusion of IL-17 blocking protein blunts hypertension and oxidative stress in response to placental ischemia, Society for Gynecologic Investigation, Orlando, FL03/2013
State/Local Invited Seminars/Lectures, The Use of Multilocus Sequence Typing to Elucidate the Evolutionary Biology of Trichomonas vaginalis, American Society of Microbiology- Mississippi College Chapter, Clinton, MS03/2012
Poster Presentation, Genetic characterization, metronidazole susceptibility testing, and secreted protease activity of clinical Trichomonas vaginalis (T. vaginalis) isolates, Annual Biomedical Research Conference for Minority Students, St. Louis, MO11/2011
Poster Presentation, Genetic and virulence characterization of Trichomonas vaginalis isolates, UMMC Graduate Research Day, Jackson, MS10/2011
Poster Presentation, Genetic characterization, metronidazole susceptibility testing, and secreted protease activity in clinical trichomonas vaginalis isolates, Eighth International Symposium on Recent Advances in Environmental Health Research, Jackson, MS09/2011
Poster Presentation, Genetic characterization, metronidazole susceptibility testing, and secreted protease activity of historical and clinical Trichomonas vaginalis Isolates, American Society of Tropical Medicine and Hygiene, Atlanta, GA11/2010
Platform Presentations, Genetics, Drug Resistance, and Virulence in Trichomonas vaginalis, University of Mississippi Medical Center School of Graduate Studies in the Health Sciences, Jackson, MS10/2010
Poster Presentation, Genetic characterization and metronidazole susceptibility testing of historical and clinical Trichomonas vaginalis isolates, University of Mississippi Medical Center School of Graduate Studies in the Health Sciences, Jackson, MS10/2009
Poster Presentation, MCF-7 breast cancer cells down-regulate macrophage migration inhibitory factor in co-cultured macrophages: implications for context-specific modulation of tumor-associated macrophages, U.S. Department of Defense Era of Hope Meeting, Baltimore, MD06/2008
Poster Presentation, Breast cancer cells down-regulate tristetraprolin in co-cultured macrophages: A possible mechanism for sustaining inflammation and angiogenesis in the tumor microenvironment, U.S. Department of Defense Era of Hope, Baltimore, MD06/2008
Poster Presentation, Transcriptional regulation of bcl-2 in proliferating epidermal keratinocytes by AP-1, American Association for Cancer Research, Los Angeles, CA04/2007
Poster Presentation, The regulation of tristetraprolin expression in tumor-associated macrophages by breast cancer cells, Howard University College of Arts and Sciences, Washington, DC03/2006
Platform Presentations, Topical Cholesterol as an effective treatment for pneumococcus keratitis, Ocular Microbiology and Immunology Group Meeting, Chicago, IL10/2005

Honors, Awards, and Recognition

2022-2023 Mid-Career Faculty Award, UMMC Chapter of the AAMC Group on Women in Medicine and Science2023
2021 Paul Dudley White International Scholar, American Heart Association Council on Hypertension2021
37th Daniel T Rolfe Scholars Memorial Heritage Lecturer, Meharry Medical College School of Medicine and School of Graduate Studies and Research2020
University of Mississippi Medical Center Gold Excellence in Research Award, University of Mississippi Medical Center2020
Water and Electrolyte Homeostasis Section Data Sciences International New Investigator Award, American Physiological Society2020
GWIMS Rising Star Award, Group on Women in Medicine and Science2020
Silver Research Excellence Award, University of Mississippi Medical Center2019
Early Career Investigator Award, University of Mississippi Medical Center2019
Fellow, American Heart Association2019
Bronze Research Excellence Award, University of Mississippi Medical Center2018
Service Recognition to HBCU Scholar Program, American Heart Association2018
Best of American Heart Association (AHA) Specialty Conferences Poster Award, American Heart Association2015
Council on Hypertension New Investigator Award, American Heart Association2015
Physiologists in Industry Committee Novel Disease Model Postdoctoral Award, American Physiological Society2015
Best of American Heart Association (AHA) Specialty Conferences Poster Award, American Heart Association2014
Annual High Blood Pressure Research Conference Top Trainee Abstract Award, American Heart Association2014
Annual High Blood Pressure Research Conference New Investigator Award, American Heart Association2014
Steven M. Horvath Professional Opportunity Award, American Physiological Society2014
Mid-Career Faculty Award, UMMC Chapter of the AAMC Group on Women in Medicine and Science2013
APS/NIDDK Minority Travel Award Fellow, American Physiological Society/ NIDDK2013
Water and Electrolyte Homeostasis Postdoctoral Research with Distinction Award, American Physiological Society2013
Student Certificate of Progress Department of Microbiology, University of Mississippi Medical Center2011
UNCF-Merck Graduate Science Research Dissertation Fellowship, United Negro College Fund- Merck Science Initiative2010
Higher Education Appreciation Day, Working for Academic Excellence (HEADWAE) Award, Mississippi Public Universities2010
School of Graduate Studies in the Health Science Graduate Research Day Poster Award, University of Mississippi Medical Center2009
Dean's Scholarship, University of Mississippi Medical Center School of Graduate Studies in Health Sciences2008

Professional Membership and Service

Society of Reproductive Investigation, Member, Annual Meeting of the Society for Reproductive Investigation2022 - Present
Shock Society, Member, Annual Conference on Shock2016 - 2022
Society of Academic Emergency Medicine, Member, SAEM Annual Meeting2015 - 2017
American Heart Association, Fellow, Council on Hypertension Scientific Sessions; AHA HBCU Scholar's Program- Mentor for undergraduate students to have meaningful research experience began in 20182013 - Present
American Physiological Society, Member, Experimental Biology- Water and Electrolyte Homeostasis Mentoring on the Go Program, Mentor for APS Minority Travel Award Fellows2012 - Present
American Society of Tropical Medicine and Hygiene, Member, American Society of Tropical Medicine and Hygiene Annual Meeting2010 - 2012

Committee Service

SCHOOL OF MEDICINE-FACULTY APPOINTMENTS, PROMOTIONS AND TENURE, Member2022 - Present
Federation of American Societies for Experimental Biology Board of Directors, Member2022 - Present
Department of Emergency Medicine Promotions and Tenure Committee, Member2022 - 2022
American Heart Association Council on Hypertension Leadership Committee, Member2021 - Present
MEDICAL CENTER-RESEARCH ADVISORY, Member2021 - Present
Research Compliance Management, Member2021 - Present
Emergency Medicine Diversity, Equity, Inclusion Planning Committee, Member2020 - Present
Editor Search Committee for Hypertension Journal, Member2020 - 2021
American Heart Association Hypertension Fall Specialty Conference Planning Committee of the Council on Hypertension, Member2020 - Present
Group on Women in Medicine and Science Executive Board, Steering Comittee Member2020 - 2021
School of Medicine Discovery Curriculum Committee, Member2020 - Present
MEDICAL CENTER-INSTITUTIONAL BIOSAFETY, Vice Chair2019 - 2022
American Physiological Society Finance Committee, Member2019 - Present
Group on Women in Medicine and Science Membership Committee, Member2018 - 2020
Group on Women in Medicine and Science Mentoring Committee, Member2018 - 2019
American Heart Association Hypertension Membership and Communications Committee, Member2017 - 2020
The American Physiological Society Water and Electrolyte Homeostasis Section, Steering Comittee Member2017 - 2020
MEDICAL CENTER-INSTITUTIONAL BIOSAFETY, Member2017 - 2019
Advisory Committee for Office of Postdoctoral Studies in Graduate School of Biomedical Sciences, Member2014 - 2016
University of Mississippi Medical Center Hospitality Committee, Member2009 - 2010

Community Service

Hopkins County Detention Center, Volunteer Minister05/2022 - Present
Habitat for Humanity, Volunteer11/2021 - Present
Science Fair Judge at Michelle Obama Early College High School, Judge03/2019 - Present
Local and Regional High School Science Fair, Judge01/2019 - Present
Glory Revival Center, Praise and Worship Leader05/2017 - Present
Discovery U, Volunteer01/2016 - 01/2016
Physiology Understanding Week, Volunteer10/2013 - 11/2018
Glory Revival Center, Board Member04/2013 - Present
Spirit Life Training Center, Volunteer04/2013 - 08/2017
Local and Regional Middle and High School Science Fairs, Judge2012 - Present
Gleaners, Inc., Volunteer2009 - 12/2011
New McRaven Hill M.B. Church, Choreographer11/2005 - 05/2008
Friendship Praise and Worship Center, Choreographer10/2003 - 05/2010

Other Service

NIH Environmental Determinants of Disease Study Section Standing Member07/2022 - Present
Graduate Women in Science (GWIS) National Fellowship Program06/2022 - 06/2022
NIH- Systemic Injury by Environemental Exposures (SIEE) Study Section09/2021 - 07/2022
NIH Image Guided Interventions and Surgery (IGIS) Study Section06/2021 - 06/2021
Chair, Clinical Fellowship Review Panel, American Heart Association, Chair04/2021 - Present
NIH Renal/Urological Sciences Small Business Activities Special Emphasis Panel (SBIR)02/2021 - 02/2021
Co-Chair, Career Development Award Clinical 1 Review Panel, American Heart Association, Co-Chair2021 - 02/2021
Co-Chair, Clinical Fellowship Review Panel,American Heart Association, Co-Chair12/2020 - 03/2021
NIH Hypertension and Microcirculation Study Section02/2020 - 02/2020
UNMC Center for Heart and Vascular Research Pilot Program (in collaboration with the Great Plains IDeA-CTR)11/2019 - Present
American Heart Association, Transformative Project Award- Basic Sciences2019 - 12/2019
American Journal of Physiology-Heart and Circulatory Physiology2019 - Present
Immunologic Research2019 - Present
Life Sciences2019 - Present
Gene2019 - Present
International Journal of Molecular Sciences2019 - Present
Hypertension in Pregnancy2019 - Present
Pharmacological Reports2019 - Present
Human Immunology2019 - Present
American Heart Association, Innovative Project Award Program2018 - 12/2018
Oxidative Medicine and Cellular Longevity2018 - Present
Journal of Hypertension2018 - Present
International Journal of Developmental Neuroscience2018 - Present
Heliyon2018 - Present
Evidence Based Complementary and Alternative Medicine2018 - Present
Journal of Thoracic Disease2018 - Present
Cardiology Research2018 - Present
Canadian Journal of Physiology and Pharmacology2018 - Present
BMC Pregnancy and Childbirth2018 - Present
Brazilian Journal of Medical and Biological Research2018 - Present
American Journal of Tropical Medicine and Hygiene2018 - Present
American Journal of Pathology2018 - Present
Kabala International Journal of Modern Science2018 - Present
Medical Journal of Obstetrics and Gynecology2018 - Present
Biomarker Insights12/2017 - Present
Innate Immunity11/2017 - Present
Journal of Diabetes Research11/2017 - Present
Disease Markers04/2017 - Present
The American Physiological Society Porter Minority Travel Fellowship, Mentor04/2017 - Present
The American Physiological Society Water Electrolyte and Homeostasis Section, Mentor04/2017 - Present
Clinical Microbiology Reviews03/2017 - Present
American Heart Association, Vascular Endothelial Biology/Clinical Review Panel03/2017 - 10/2019
Journal of Intensive Care Medicine02/2017 - Present
Archives of Emergency Medicine and Critical Care02/2016 - Present
BMJ Open01/2016 - Present
European Journal of Obstetrics and Gynecology and Reproductive Biology, Ad Hoc Reviewer01/2016 - Present
Scandinavian Journal of Immunology, Ad Hoc Reviewer10/2015 - Present
Microbiological Insights02/2015 - Present
Libertas Academica2015 - Present
Graduate School of Biomedical Sciences, Recruiter2014 - 12/2014
Circulation2014 - Present
Hypertension2014 - Present
School of Dentistry, Tutor of Dental Microbiology09/2011 - 05/2012
School of Medicine, Tutor09/2010 - 05/2012

Teaching Experience

Graduate, Course, Lecturer, Mechanisms of Drug ActionSpring 2022
Dentistry, Course, Lecturer, Fundamentals of PharmacologySpring 2022
ID714, Graduate, Course, Lecturer, Professional SkillsSpring 2022
Medicine, Course, Lecturer, Medical PharmacologyFall 2021
Graduate, Course, Lecturer, Mechanisms of Drug ActionSpring 2021
Graduate, Course, Lecturer, Mechanisms of Drug ActionSpring 2020
Medicine, Course, Lecturer, Medical PharmacologyFall 2020
Medicine, Lecture, Lecturer, Emergency Medicine Residency ConferenceAnnual 2020
ID714, Graduate, Course, Lecturer, Professional SkillsSpring 2020
PHARM724, Graduate, Course, Lecturer, Experimental Design and MethodsSpring 2020
Medicine, Lecture, Lecturer, Emergency Medicine Residency ConferenceAnnual 2019
PHARM724, Graduate, Course, Lecturer, Experimental Design and MethodsSpring 2019
Medicine, Course, Lecturer, Medical PharmacologyFall 2019 - 2019
Medicine, Small Group, Facilitator, Medical PharmacologyFall 2019
ID714, Graduate, Course, Lecturer, Professional DevelopmentSpring 2019
PHARM723, Graduate, Course, Lecturer, Mechanisms of Drug ActionsSpring 2019
Medicine, Lecture, Lecturer, Emergency Medicine Residency ConferenceAnnual 2018
Medicine, Course, Lecturer, Medical PharmacologyFall 2018
Medicine, Small Group, Facilitator, Medical PharmacologyFall 2018
Medicine, Lecture, Lecturer, Emergency Medicine Residency ConferenceAnnual 2017
Medicine, Course, Lecturer, Medical PharmacologySpring 2017
Medicine, Small Group, Facilitator, Medical PharmacologyFall 2017 - 2017
Medicine, Course, Lecturer, Medical PharmacologyFall 2017 - 2017
Medicine, Lecture, Lecturer, Emergency Medicine Residency ConferenceAnnual 2016
Medicine, Course, Lecturer, Medical PharmacologySpring 2016
Medicine, Course, Lecturer, Medical PharmacologySpring 2015 - 2015
Medicine, Small Group, Facilitator, Medical PharmacologyFall 2014 - 2015
Graduate, Course, Lecturer, MFM Research Tools in Molecular BiologySpring 2014 - 2014
Graduate, Course, Lecturer, Foundations of NeuroscienceFall 2013 - 2014
Graduate, Course, Lecturer, MFM Research Tools in Molecular BiologySpring 2013 - 2014
Medicine, Lab, Student Assistant, Medical MicrobiologyFall 2010 - 2011

Directed Student Learning

Supervised Research, Advised: Jaylen Sandifer2022 - Present
Supervised Research, Advised: Candace Carter2022 - Present
Dissertation Committee Member, Insulin resistance-mediated renal macrophage inflammatory protein 3-alpha stimulates renal injury in pre-pubertal obesity.
Advised: Ubong Ekperikpe
2021 - Present
Supervised Research, Advised: Tatiana Davis2021 - 2021
Supervised Research, Advised: Hannah Glenn, Christopher Nutter2021 - 2021
Supervised Research, Advised: Olive Cooper, Rashauna Thomas2021 - 2021
Dissertation Committee Chair, NLRP3 Inflammasome Signaling in Placental Ischemia-induced Pathophysiology
Advised: Xi Wang
2021 - Present
Research Advisor, Advised: La'Deira Hall2020 - 2021
Dissertation Committee Member, The Role of B Lymphocytes in the Pathophysiology of Hypertension in Response to Placental Ischemia
Advised: Owen Herrock
2020 - Present
Dissertation Committee Member, The Role of TH17 cells and IL-17 in causing Mitochondrial Dysfunction in Response to Placental Ischemia and its Impact on the IUGR Offspring
Advised: Sarah Fitzgerald
2020 - Present
Supervised Research, Advised: Madison Crosby2020 - 2020
Supervised Research, Advised: Henry Nguyen2020 - 2020
Supervised Research, Advised: Shanni Siddiq2019 - 2021
Supervised Research, Normal Placental Cells Attenuate Preeclampsia Symptoms in Response to Placental Ischemia
Advised: Rachel Coleman
2019 - 2021
Supervised Research, Advised: David Fleming2019 - 2019
Undergraduate Honors Thesis, Placental Ischemia-Stimulated Natural Killer Cells Induce Preeclampsia Pathophysiology in Pregnant Rats
Advised: Carmilya Jackson
2018 - 2019
Supervised Research, Advised: Chanmee Seo2018 - 2020
Research Advisor, Advised: Robert Tramel2018 - 2021
Research Advisor, Advised: Mallory Greer2018 - 2018
Supervised Research, Advised: Sumit Santakke2017 - 2017
Supervised Research, Advised: Shaoxun Wang2017 - 2017
Dissertation Committee Chair, A Role for Natural Killer Cells in the Pathophysiology of Hypertension and Intrauterine Growth Restriction during Pregnancy
Advised: Olivia Travis
2017 - 2021
Dissertation Committee Member, Advised: Bibek Poudel2017 - 2021
Supervised Research, Advised: Jeanne Ishimwe2017 - 2017
Dissertation Committee Member, Advised: Corbin Shields2016 - 2021
Supervised Research, Advised: Ashley Gnam2016 - 2017
Undergraduate Honors Thesis, Platelet-Derived Microparticles and their role in sepsis
Advised: Robert Tramel
2016 - 2017
Supervised Research, Advised: Jack Tharp2015 - 2015
Supervised Research, Advised: Taia McAfee2015 - 2016
Supervised Research, Advised: Tarek Ibrahim2014 - 2015
Supervised Research, Advised: Jessica Faulkner2014 - 2015
Supervised Research, Immune Suppression and AT1-AA Blockade: Novel Treatments for Preeclampsia
Advised: Ashlyn Harmon
2013 - 2015
Supervised Research, Advised: Adrienne Paige2013 - 2014
Supervised Research, Advised: Justin Porter2013 - 2013
Supervised Research, Advised: Nathan Campbell2013 - 2015
Supervised Research, Advised: Alexia Thomas2013 - 2014
Supervised Research, Advised: Antrice Walker2011 - 2011

Fellows supervised

Postdoctoral Fellowship, Post-Doc Advisor, 1 fellows supervised07/2021 - Present
Pediatric Intensive Care Unit Fellowship, Research Advisor, 1 fellows supervised, Research03/2018 - 06/2020
Trauma Surgery, Training Faculty, 1 fellows supervised08/2017 - 06/2019
Emergency Medicine, Training Faculty, 1 fellows supervised07/2016 - 06/2018
MFM Fellowship Program, Supervised Research, 8 fellows supervised08/2012 - 06/2019

Residency Training

Emergency Medicine, Research Advisor2021 - 06/2022
Emergency Medicine Residency, Subspecialty/Activity Director2016 - Present