Denise C. Cornelius, PhD
Associate Professor
Department:
SOM-Pharmacology/Toxicology
Email:
dcornelius@umc.edu
Work Phone:
(601) 815-1551
Biography
Dr. Cornelius is an Associate Professor and the Director of Pre-Clinical Research in the Department of Emergency Medicine at the University of Mississippi Medical Center.
Dr. Cornelius is currently a member of Frontiers in Physiology and BMC Pregnancy and Childbirth. She also serves as a reviewer for a number of journals including Hypertension, American Journal of Physiology: Regulatory and Integrative Physiology, Ciculation, and Journal of Thoracic Disease. She has published over 60 peer reviewed manuscripts, book chapters, and editorials in leading journals for the field of hypertension research and cardiovascular physiology.
Dr. Cornelius serves in multiple leadership capacities. She currently serves on the AMericna Heart Association's Council on Hypertension Leadership Committee and the American Physiological Society's Financial Committee and. She recently began her term as a standing member of the NIH Systemic Injury from Environmental Exposure Study section and as Chair of the AHA Fellowship Grant Reveiw Panel. At the institutional level, Dr. Cornelius serves as the Vice Chair of the Institutional Biosafety Committee, a member of the Research Compliance Committee and Co-Director of the MCCTR Mentor Academy. Dr. Cornelius also lectures in the medical, dental, and graduate school courses, and serves as a research mentor for trainees at all levels.
Dr. Cornelius has received several awards throughout her career including the UNCF-Merck Graduate Dissertation Science Research Fellowship, the American Physiological Society Minority Travel Award, the American Physiological Society Water and Electrolyte Homeostasis Postdoctoral Research with Distinction Award, and the American Heart Association’s Council on Hypertension New Investigator’s Award. She was selected as UMMC's Early Career Investigator (2019), the WEH Section New Investigator of the Year (2020) and the GWIMS Early Career Rising Star (2020).
Dr. Cornelius’s laboratory has research focus in two major areas. The first is related to understanding how immune system activation mechanistically promotes the pathogenesis of hypertension and intrauterine growth restriction during pregnancy. Using multiple experimental models of preeclampsia, Dr. Cornelius’s lab investigates the renal and vascular mechanisms during preeclampsia and how they are influenced by inflammatory and cytotoxic immune cells and mediators. The second is related to understanding mechanisms that lead to the development of multi-organ injury during sepsis. Patients with sepsis have increased platelet activation are prone to develop multi-organ failure and have poor clinical outcomes. Dr. Cornelius’s laboratory uses a modified cecal ligation and puncture model that mimics characteristics of sepsis to investigate an important role for activated platelets in the development of multi-organ injury in sepsis.
Education
| University of Mississippi Medical Center, Postdoctoral Research Fellow, Physiology/Pharmacology | 2015 |
| University of Mississippi Medical Center, PhD, Microbiology/Immunology | 2012 |
| University of Mississippi Medical Center, MS, Biomedical Sciences | 2010 |
| Howard University, BS, Biology | 2006 |
Specialty Certification Licensure
| Certification, Data Management in Clinical Research | 07/2023 - Present |
Current Positions
| Associate Professor, School of Medicine, Department of Pharmacology / Toxicology | 09/2022 - Present |
| Associate Professor, School of Medicine, Department of Emergency Medicine | 09/2022 - Present |
| Director of Immuno-Assay Core, School of Medicine, Department of Pharmacology / Toxicology | 09/2022 - Present |
| Director of Pre-Clinical Research, School of Medicine, Department of Emergency Medicine | 07/2015 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Emergency Medicine | 07/2021 - 09/2021 |
| Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 07/2021 - 09/2022 |
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Emergency Medicine | 09/2017 - 06/2021 |
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 09/2017 - 06/2021 |
| Instructor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 07/2015 - 08/2017 |
| Instructor, University of Mississippi Medical Center, School of Medicine, Department of Emergency Medicine | 07/2015 - 08/2017 |
Sponsored Program Funding
| Extramural, Hypertension, Inflammation, and Vascular Function, NIH/National Heart Lung and Blood Institute | 05/2020 - 03/2025 |
| Extramural, A Role for Natural Killer Cells in the Development of Intrauterine Growth Restriction and Hypertension During Pregnancy, NIH/National Heart Lung and Blood Institute | 04/2020 - 03/2022 |
| Extramural, Mechanisms Linking Platelet Activation with Sepsis Pathophysiology, NIH/National Institute of General Medical Sciences | 11/2017 - 11/2019 |
| Extramural, Hypertension and Inflammation, NIH/National Heart Lung and Blood Institute | 09/2016 - 08/2021 |
| Extramural, Natural killers cells as mediators of hypertension in response to placental ischemia, American Heart Association | 01/2016 - 12/2020 |
| Extramural, Hypertension, the kidney, and inflammation, NIH/National Heart Lung Blood Institute | 12/2014 - 11/2015 |
| Extramural, Population Genetics, characterization of virulence factors, and epidemiology of Trichomonas vaginalis, United Negro College Fund- Merck Science Initiative | 10/2010 - 04/2012 |
Publications
Journal Article | |
| Poudel B, Shields CA, Ekperikpe US, Brown AK, Travis OK, Maury JC, Fitzgerald S, Smith SV, Cornelius DC, Williams JM, The SS(LepR) mutant rat represents a novel model to study obesity-induced renal injury before puberty. American journal of physiology. Regulatory, integrative and comparative physiology, 2022 Apr 1;322(4):R299-R308 | 2022 |
| Cornelius DC, Wang X, Griffin A, Morris R, Wallace K, Preeclampsia and COVID-19: the Role of Inflammasome Activation. Current hypertension reports, 2022 Sep;24(9):341-348 | 2022 |
| Deer E, Jones J, Cornelius DC, Comley K, Herrock O, Campbell N, Fitzgerald S, Ibrahim T, LaMarca B, Amaral LM, Progesterone Induced Blocking Factor Reduces Hypertension and Placental Mitochondrial Dysfunction in Response to sFlt-1 during Pregnancy. Cells, 2021 Oct 20;10(11) | 2021 |
| Vaka R, Deer E, Cunningham M, McMaster KM, Wallace K, Cornelius DC, Amaral LM, LaMarca B, Characterization of Mitochondrial Bioenergetics in Preeclampsia. Journal of clinical medicine, 2021 Oct 29;10(21) | 2021 |
| Borges-Rodriguez M, Shields CA, Travis OK, Tramel RW, Baik CH, Giachelli CA, Tardo GA, Williams JM, Cornelius DC, Platelet Inhibition Prevents NLRP3 Inflammasome Activation and Sepsis-Induced Kidney Injury. International journal of molecular sciences, 2021 Sep 25;22(19) | 2021 |
| Travis OK, Tardo GA, Giachelli C, Siddiq S, Nguyen HT, Crosby MT, Johnson TD, Brown AK, Booz GW, Smith AN, Williams JM, Cornelius DC, Interferon γ neutralization reduces blood pressure, uterine artery resistance index, and placental oxidative stress in placental ischemic rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2021 Aug 1;321(2):R112-R124 | 2021 |
| Travis OK, Tardo GA, Giachelli C, Siddiq S, Nguyen HT, Crosby MT, Johnson T, Brown AK, Williams JM, Cornelius DC, Tumor Necrosis Factor-alpha Blockade Improves Uterine Artery Resistance, Maternal Blood Pressure, and Fetal Growth in Placental Ischemic Rats. Pregnancy hypertension, 2021 Aug;25:39-47 | 2021 |
| Jayaram A, Deer E, Amaral LM, Campbell N, Vaka VR, Cunningham M, Ibrahim T, Cornelius DC, LaMarca BB, The role of tumor necrosis factor in triggering activation of natural killer cell, multi-organ mitochondrial dysfunction and hypertension during pregnancy. Pregnancy hypertension, 2021 Jun;24:65-72 | 2021 |
| Cottrell JN, Witcher AC, Comley K, Cunningham MW Jr, Ibrahim T, Cornelius DC, LaMarca B, Amaral LM, Progesterone-induced blocking factor improves blood pressure, inflammation, and pup weight in response to reduced uterine perfusion pressure (RUPP). American journal of physiology. Regulatory, integrative and comparative physiology, 2021 May 1;320(5):R719-R727 | 2021 |
| Deer E, Vaka VR, McMaster KM, Wallace K, Cornelius DC, Amaral LM, Cunningham MW, LaMarca B, Vascular endothelial mitochondrial oxidative stress in response to preeclampsia: a role for angiotension II type 1 autoantibodies. American journal of obstetrics & gynecology MFM, 2021 Jan;3(1):100275 | 2021 |
| Cunningham MW Jr, Amaral LM, Campbell NE, Cornelius DC, Ibrahim T, Vaka VR, LaMarca B, Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia. Biology of sex differences, 2021 Jan 6;12(1):4 | 2021 |
| Travis OK, Baik C, Tardo GA, Amaral L, Jackson C, Greer M, Giachelli C, Ibrahim T, Herrock OT, Williams JM, Cornelius DC, Adoptive transfer of placental ischemia-stimulated natural killer cells causes a preeclampsia-like phenotype in pregnant rats. American journal of reproductive immunology (New York, N.Y. : 1989), 2021 Jun;85(6):e13386 | 2021 |
| Deer E, Reeve KE, Amaral L, Vaka VR, Franks M, Campbell N, Fitzgerald S, Herrock O, Ibrahim T, Cornelius D, LaMarca B, CD4+ T cells cause renal and placental mitochondrial oxidative stress as mechanisms of hypertension in response to placental ischemia. American journal of physiology. Renal physiology, 2021 Jan 1;320(1):F47-F54 | 2021 |
| McPherson KC, Shields CA, Poudel B, Johnson AC, Taylor L, Stubbs C, Nichols A, Cornelius DC, Garrett MR, Williams JM, Altered renal hemodynamics is associated with glomerular lipid accumulation in obese Dahl salt-sensitive leptin receptor mutant rats. American journal of physiology. Renal physiology, 2020 Apr 1;318(4):F911-F921 | 2020 |
| Elfarra JT, Cottrell JN, Cornelius DC, Cunningham MW Jr, Faulkner JL, Ibrahim T, Lamarca B, Amaral LM, 17-Hydroxyprogesterone caproate improves T cells and NK cells in response to placental ischemia; new mechanisms of action for an old drug. Pregnancy hypertension, 2020 Jan;19:226-232 | 2020 |
| Vaka VR, Cunningham MW, Deer E, Franks M, Ibrahim T, Amaral LM, Usry N, Cornelius DC, Dechend R, Wallukat G, LaMarca BD, Blockade of endogenous angiotensin II type I receptor agonistic autoantibody activity improves mitochondrial reactive oxygen species and hypertension in a rat model of preeclampsia. American journal of physiology. Regulatory, integrative and comparative physiology, 2020 Feb 1;318(2):R256-R262 | 2020 |
| Poudel B, Shields CA, Brown AK, Ekperikpe U, Johnson T, Cornelius DC, Williams JM, Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats. American journal of physiology. Renal physiology, 2020 Jun 1;318(6):F1489-F1499 | 2020 |
| Travis OK, White D, Baik C, Giachelli C, Thompson W, Stubbs C, Greer M, Lemon JP, Williams JM, Cornelius DC, Interleukin-17 signaling mediates cytolytic natural killer cell activation in response to placental ischemia. American journal of physiology. Regulatory, integrative and comparative physiology, 2020 Jun 1;318(6):R1036-R1046 | 2020 |
| Cornelius DC, Wallace K, Autophagy in preeclampsia: A new target? EBioMedicine, 2020 Jul;57:102864 | 2020 |
| Cunningham MW, Jayaram A, Deer E, Amaral LM, Vaka VR, Ibrahim T, Cornelius DC, LaMarca B, Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia. Hypertension in pregnancy, 2020 Nov;39(4):399-404 | 2020 |
| Cornelius DC, Cottrell J, Amaral LM, LaMarca B, Inflammatory mediators: a causal link to hypertension during preeclampsia. British journal of pharmacology, 2019 Jun;176(12):1914-1921 | 2019 |
| Cunningham MW Jr, Vaka VR, McMaster K, Ibrahim T, Cornelius DC, Amaral L, Campbell N, Wallukat G, McDuffy S, Usry N, Dechend R, LaMarca B, Renal natural killer cell activation and mitochondrial oxidative stress; new mechanisms in AT1-AA mediated hypertensive pregnancy. Pregnancy hypertension, 2019 Jan;15:72-77 | 2019 |
| Harmon AC, Ibrahim T, Cornelius DC, Amaral LM, Cunningham MW Jr, Wallace K, LaMarca B, Placental CD4(+) T cells isolated from preeclamptic women cause preeclampsia-like symptoms in pregnant nude-athymic rats. Pregnancy hypertension, 2019 Jan;15:7-11 | 2019 |
| Vaka VR, McMaster KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca B, Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in reduced uterine perfusion pressure rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2019 May 1;316(5):R441-R447 | 2019 |
| Cottrell JN, Amaral LM, Harmon A, Cornelius DC, Cunningham MW Jr, Vaka VR, Ibrahim T, Herse F, Wallukat G, Dechend R, LaMarca B, Interleukin-4 supplementation improves the pathophysiology of hypertension in response to placental ischemia in RUPP rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2019 Feb 1;316(2):R165-R171 | 2019 |
| Cornelius DC, Wallace K, Decidual natural killer cells: A critical pregnancy mediator altered in preeclampsia. EBioMedicine, 2019 Jan;39:31-32 | 2019 |
| McPherson KC, Shields CA, Poudel B, Fizer B, Pennington A, Szabo-Johnson A, Thompson WL, Cornelius DC, Williams JM, Impact of obesity as an independent risk factor for the development of renal injury: implications from rat models of obesity. American journal of physiology. Renal physiology, 2019 Feb 1;316(2):F316-F327 | 2019 |
| Baik CH, Geer M, Travis OK, Cornelius DC, A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function. Journal of visualized experiments : JoVE, 2019 Jun 2;(148) | 2019 |
| Cornelius DC, Baik CH, Travis OK, White DL, Young CM, Austin Pierce W, Shields CA, Poudel B, Williams JM, NLRP3 inflammasome activation in platelets in response to sepsis. Physiological reports, 2019 May;7(9):e14073 | 2019 |
| Travis OK, White D, Pierce WA, Ge Y, Stubbs CY, Spradley FT, Williams JM, Cornelius DC, Chronic infusion of interleukin-17 promotes hypertension, activation of cytolytic natural killer cells, and vascular dysfunction in pregnant rats. Physiological reports, 2019 Apr;7(7):e14038 | 2019 |
| Puskarich MA, Cornelius DC, Bandyopadhyay S, McCalmon M, Tramel R, Dale WD, Jones AE, Phosphatidylserine expressing platelet microparticle levels at hospital presentation are decreased in sepsis non-survivors and correlate with thrombocytopenia. Thrombosis research, 2018 Aug;168:138-144 | 2018 |
| Vaka VR, McMaster KM, Cunningham MW Jr, Ibrahim T, Hazlewood R, Usry N, Cornelius DC, Amaral LM, LaMarca B, Role of Mitochondrial Dysfunction and Reactive Oxygen Species in Mediating Hypertension in the Reduced Uterine Perfusion Pressure Rat Model of Preeclampsia. Hypertension (Dallas, Tex. : 1979), 2018 Sep;72(3):703-711 | 2018 |
| Spires D, Poudel B, Shields CA, Pennington A, Fizer B, Taylor L, McPherson KC, Cornelius DC, Williams JM, Prevention of the progression of renal injury in diabetic rodent models with preexisting renal disease with chronic endothelin A receptor blockade. American journal of physiology. Renal physiology, 2018 Oct 1;315(4):F977-F985 | 2018 |
| Shields CA, McCalmon M, Ibrahim T, White DL, Williams JM, LaMarca B, Cornelius DC, Placental ischemia-stimulated T-helper 17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy. American journal of physiology. Regulatory, integrative and comparative physiology, 2018 Aug 1;315(2):R336-R343 | 2018 |
| Cunningham MW Jr, Castillo J, Ibrahim T, Cornelius DC, Campbell N, Amaral L, Vaka VR, Usry N, Williams JM, LaMarca B, AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) Blockade Prevents Preeclamptic Symptoms in Placental Ischemic Rats. Hypertension (Dallas, Tex. : 1979), 2018 May;71(5):886-893 | 2018 |
| Faulkner JL, Amaral LM, Cornelius DC, Cunningham MW, Ibrahim T, Heep A, Campbell N, Usry N, Wallace K, Herse F, Dechend R, LaMarca B, Vitamin D supplementation reduces some AT1-AA-induced downstream targets implicated in preeclampsia including hypertension. American journal of physiology. Regulatory, integrative and comparative physiology, 2017 Jan 1;312(1):R125-R131 | 2017 |
| Ibrahim T, Przybyl L, Harmon AC, Amaral LM, Faulkner JL, Cornelius DC, Cunningham MW, Hünig T, Herse F, Wallukat G, Dechend R, LaMarca B, Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy. American journal of reproductive immunology (New York, N.Y. : 1989), 2017 Nov;78(5) | 2017 |
| Small HY, Cornelius DC, Guzik TJ, Delles C, Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy. Placenta, 2017 Aug;56:59-64 | 2017 |
| Amaral LM, Faulkner JL, Elfarra J, Cornelius DC, Cunningham MW, Ibrahim T, Vaka VR, McKenzie J, LaMarca B, Continued Investigation Into 17-OHPC: Results From the Preclinical RUPP Rat Model of Preeclampsia. Hypertension (Dallas, Tex. : 1979), 2017 Dec;70(6):1250-1255 | 2017 |
| Elfarra J, Amaral LM, McCalmon M, Scott JD, Cunningham MW Jr, Gnam A, Ibrahim T, LaMarca B, Cornelius DC, Natural killer cells mediate pathophysiology in response to reduced uterine perfusion pressure. Clinical science (London, England : 1979), 2017 Dec 1;131(23):2753-2762 | 2017 |
| Cornelius DC, McCalmon M, Tharp J, Puskarich M, Jones AE Fluid Resuscitation in Animal Models of Sepsis: A Comprehensive Review of the Current State of Knowledge Archives of Emergency Medicine and Critical Care. 2016; 1:1002 | 2016 |
| Harmon AC, Cornelius DC, Amaral LM, Faulkner JL, Cunningham MW Jr, Wallace K, LaMarca B, The role of inflammation in the pathology of preeclampsia. Clinical science (London, England : 1979), 2016 Mar;130(6):409-19 | 2016 |
| Faulkner JL, Cornelius DC, Amaral LM, Harmon AC, Cunningham MW Jr, Darby MM, Ibrahim T, Thomas DS, Herse F, Wallukat G, Dechend R, LaMarca B, Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia. American journal of physiology. Regulatory, integrative and comparative physiology, 2016 Feb 15;310(4):R346-54 | 2016 |
| LaMarca B, Cornelius DC, Harmon AC, Amaral LM, Cunningham MW, Faulkner JL, Wallace K, Identifying immune mechanisms mediating the hypertension during preeclampsia. American journal of physiology. Regulatory, integrative and comparative physiology, 2016 Jul 1;311(1):R1-9 | 2016 |
| LaMarca B, Amaral LM, Harmon AC, Cornelius DC, Faulkner JL, Cunningham MW Jr, Placental Ischemia and Resultant Phenotype in Animal Models of Preeclampsia. Current hypertension reports, 2016 Apr;18(5):38 | 2016 |
| Puskarich MA, Cornelius DC, Tharp J, Nandi U, Jones AE, Plasma syndecan-1 levels identify a cohort of patients with severe sepsis at high risk for intubation after large-volume intravenous fluid resuscitation. Journal of critical care, 2016 Dec;36:125-129 | 2016 |
| Cornelius DC, Amaral LM, Wallace K, Campbell N, Thomas AJ, Scott J, Herse F, Wallukat G, Dechend R, LaMarca B, Reduced uterine perfusion pressure T-helper 17 cells cause pathophysiology associated with preeclampsia during pregnancy. American journal of physiology. Regulatory, integrative and comparative physiology, 2016 Dec 1;311(6):R1192-R1199 | 2016 |
| Amaral LM, Cornelius DC, Harmon A, Moseley J, Martin JN Jr, LaMarca B, 17-hydroxyprogesterone caproate significantly improves clinical characteristics of preeclampsia in the reduced uterine perfusion pressure rat model. Hypertension (Dallas, Tex. : 1979), 2015 Jan;65(1):225-31 | 2015 |
| Cornelius DC, Amaral LM, Harmon A, Wallace K, Thomas AJ, Campbell N, Scott J, Herse F, Haase N, Moseley J, Wallukat G, Dechend R, LaMarca B, An increased population of regulatory T cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia. American journal of physiology. Regulatory, integrative and comparative physiology, 2015 Oct 15;309(8):R884-91 | 2015 |
| Cornelius DC, Castillo J, Porter J, Amaral LM, Campbell N, Paige A, Thomas AJ, Harmon A, Cunningham MW Jr, Wallace K, Herse F, Wallukat G, Dechend R, LaMarca B, Blockade of CD40 ligand for intercellular communication reduces hypertension, placental oxidative stress, and AT1-AA in response to adoptive transfer of CD4+ T lymphocytes from RUPP rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2015 Nov 15;309(10):R1243-50 | 2015 |
| Wallace K, Morris R, Kyle PB, Cornelius D, Darby M, Scott J, Moseley J, Chatman K, Lamarca B, Hypertension, inflammation and T lymphocytes are increased in a rat model of HELLP syndrome. Hypertension in pregnancy, 2014 Feb;33(1):41-54 | 2014 |
| Amaral LM, Kiprono L, Cornelius DC, Shoemaker C, Wallace K, Moseley J, Wallukat G, Martin JN Jr, Dechend R, LaMarca B, Progesterone supplementation attenuates hypertension and the autoantibody to the angiotensin II type I receptor in response to elevated interleukin-6 during pregnancy. American journal of obstetrics and gynecology, 2014 Aug;211(2):158.e1-6 | 2014 |
| Cornelius DC, Lamarca B, TH17- and IL-17- mediated autoantibodies and placental oxidative stress play a role in the pathophysiology of pre-eclampsia. Minerva ginecologica, 2014 Jun;66(3):243-9 | 2014 |
| Wallace K, Cornelius DC, Scott J, Heath J, Moseley J, Chatman K, LaMarca B, CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia. Hypertension (Dallas, Tex. : 1979), 2014 Nov;64(5):1151-8 | 2014 |
| LaMarca B, Cornelius D, Wallace K, Elucidating immune mechanisms causing hypertension during pregnancy. Physiology (Bethesda, Md.), 2013 Jul;28(4):225-33 | 2013 |
| Cornelius DC, Hogg JP, Scott J, Wallace K, Herse F, Moseley J, Wallukat G, Dechend R, LaMarca B, Administration of interleukin-17 soluble receptor C suppresses TH17 cells, oxidative stress, and hypertension in response to placental ischemia during pregnancy. Hypertension (Dallas, Tex. : 1979), 2013 Dec;62(6):1068-73 | 2013 |
| Cornelius DC, Wallace K, Kiprono L, Dhillon P, Moseley J, LaMarca B, Endothelin-1 is not a Mechanism of IL-17 Induced Hypertension during Pregnancy. Medical journal of obstetrics and gynecology, 2013 Sep 19;1(1) | 2013 |
| Darby MM, Wallace K, Cornelius D, Chatman KT, Mosely JN, Martin JN, Purser CA, Baker RC, Owens MT, Lamarca BB, Vitamin D Supplementation Suppresses Hypoxia-Stimulated Placental Cytokine Secretion, Hypertension and CD4(+) T Cell Stimulation in Response to Placental Ischemia. Medical journal of obstetrics and gynecology, 2013 Sep 23;1(2) | 2013 |
| Cornelius DC, Robinson DA, Muzny CA, Mena LA, Aanensen DM, Lushbaugh WB, Meade JC, Genetic characterization of Trichomonas vaginalis isolates by use of multilocus sequence typing. Journal of clinical microbiology, 2012 Oct;50(10):3293-300 | 2012 |
| Cornelius DC, Mena L, Lushbaugh WB, Meade JC, Genetic relatedness of Trichomonas vaginalis reference and clinical isolates. The American journal of tropical medicine and hygiene, 2010 Dec;83(6):1283-6 | 2010 |
| Harmon A, Cornelius D, Amaral L, Paige A, Herse F, Ibrahim T, Wallukat G, Faulkner J, Moseley J, Dechend R, LaMarca B, IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia. Hypertension in pregnancy, 2015;34(3):291-306 | |
| Cornelius DC, Preeclampsia: From Inflammation to Immunoregulation. Clinical medicine insights. Blood disorders, 2018;11:1179545X17752325 | |
| Amaral LM, Cunningham MW Jr, Cornelius DC, LaMarca B, Preeclampsia: long-term consequences for vascular health. Vascular health and risk management, 2015;11:403-15 | |
| Burnett GT, Weathersby DC, Taylor TE, Bremner TA, Regulation of inflammation- and angiogenesis-related gene expression in breast cancer cells and co-cultured macrophages. Anticancer research, 2008 Jul-Aug;28(4B):2093-9 | |
| Cornelius DC, Travis OK, Tramel RW, Borges-Rodriguez M, Baik CH, Greer M, Giachelli CA, Tardo GA, Williams JM, NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture. PloS one, 2020;15(6):e0234039 | |
| Brown AK, Nichols A, Coley CA, Ekperikpe US, McPherson KC, Shields CA, Poudel B, Cornelius DC, Williams JM, Treatment With Lisinopril Prevents the Early Progression of Glomerular Injury in Obese Dahl Salt-Sensitive Rats Independent of Lowering Arterial Pressure. Frontiers in physiology, 2021;12:765305 | |
| Shields CA, Poudel B, McPherson KC, Brown AK, Ekperikpe US, Browning E, Sutton L, Cornelius DC, Williams JM, Treatment With Gemfibrozil Prevents the Progression of Chronic Kidney Disease in Obese Dahl Salt-Sensitive Rats. Frontiers in physiology, 2020;11:566403 | |
Book Chapter | |
| Cornelius DC Sex Differences in Cardiovascular Physiology and Pathophysiology Elsevier, Cambridge, 2019 | 2019 |
| Meade JC, Cornelius DC Sexually Transmitted Infections in the Tropics, Current Topics in Tropical Medicine InTech, Rijeka, 2012 | 2012 |
Editorial | |
| Cornelius DC, Copeptin: a new biomarker that is specific for preeclampsia? Hypertension (Dallas, Tex. : 1979), 2014 Dec;64(6):1189-91 | 2014 |
Presentations
| Platform Presentations, IL-33 Supplementation Improves Vascular Function and Maternal Hypertension in Response to Placental Ischemia, American Heart Association Council on Hypertension Scientific Sessions, San Diego, CA | 09/2022 |
| National and International Invited Seminars/Lectures, Investigations into Mechanisms of Sepsis-Induced Organ Injury, Washington University School of Medicine in St. Louis Department of Emergency Medicine, St. Louis, MO | 05/2022 |
| Platform Presentations, NLRP3 inhibition improves maternal blood pressure, inflammation, and vascular function during placental ischemia, Experimental Biology, Philadelphia, PA | 04/2022 |
| Platform Presentations, IL-25 supplementation induces M2 macrophage polarization, reduces blood pressure, and improves fetal weight in placental ischemic rats, Experimental Biology, Philadelphia, PA | 04/2022 |
| Poster Presentation, Treatment with rapamycin reduces progressive proteinuria while inducing hyperglycemia in obese Dahl salt-sensitive leptin receptor mutant rats prior to puberty, Experimental Biology, Philadelphia, PA | 04/2022 |
| Poster Presentation, Decreasing insulin resistance reduces early progressive proteinuria by decreasing renal hyperfiltration and inflammation in obese Dahl salt-sensitive rats, Experimental Biology, Philadelphia, PA | 04/2022 |
| Poster Presentation, NLRP3 inhibition improves maternal blood pressure, inflammation, and vascular function during placental ischemia, Experimental Biology, Philadephia, PA | 04/2022 |
| Poster Presentation, IL-25 supplementation induces M2 macrophage polarization, reduces blood pressure, and improves fetal weight in placental ischemic rats, Experimental Biology, Philadelphia, PA | 04/2022 |
| State/Local Invited Seminars/Lectures, Black in Biology Panel, Jackson State University Biology Society, Jackson, MS | 02/2022 |
| National and International Invited Seminars/Lectures, Innate-Adaptive Immune Crosstalk in Pathophysiology of Preeclampsia, University of Michigan Samuel and Jean Frankel Cardiovascular Center, Virtual | 12/2021 |
| National and International Invited Seminars/Lectures, Characterizing Immune Mechanisms of Preeclampsia Pathophysiology, Zooming in on Preeclampsia, Virtual | 12/2021 |
| Poster Presentation, Inhibition of NLRP3 improves PE pathophysiology in Response to Placental Ischemia, Annual Biomedical Research Conference for Minority Students, Virtual | 11/2021 |
| Poster Presentation, NLRP3 inhibition improves PE pathophysiology in Response to Placental Ischemia, Annual Biomedical Research Conference for Minority Students, Virtual | 11/2021 |
| National and International Invited Seminars/Lectures, Sex Differences in Response to Sepsis, American Physiological Society’s New Trends in Sex and Gender Medicine Conference, virtual | 10/2021 |
| Poster Presentation, Progesterone induced blocking factor decreases hypertension mitochondrial dysfunction and reactive oxygen species in response to elevated sFlt-1 during pregnancy, Virtual | 09/2021 |
| Platform Presentations, IL-17 causes hypertension, reduced fetal weight, and natural killer cell activation in the absence of T cells, AHA Council on Hypertension Scientific Sessions, Virtual | 09/2021 |
| Platform Presentations, Esomeptrazole improves blood pressure, intrauterine growth restriction, inflammation, and vascular function during placental ischemia through inhibition of NLRP3, AHA Council on Hypertension Scientific Sessions, Virtual | 09/2021 |
| Platform Presentations, Inhibiting Stimulatory Dendritic Cells Reduces Early Progressive Proteinuria In Obese Dahl Saltsensitive Rats, AHA Council on Hypertension Scientific Sessions, Virtual | 09/2021 |
| Poster Presentation, Sex differences in macrophage polarization during the early progression of renal disease in obese Dahl Salt-Sensitive rats prior to puberty, Experimental Biology, Virtual | 04/2021 |
| Poster Presentation, Progesterone and PIBF: new insights into treatment options for preeclampsia, Experimental Biology, Virtual | 04/2021 |
| Poster Presentation, Elevations in arterial pressure is associated with increases in plasma angiotensin II and angiotensin 1-9 in obese SS rats prior to puberty, Experimental Biology, Virtual | 04/2021 |
| Platform Presentations, IL-17 Causes hypertension and multi-organ dysfunction which is attenuated with blockade of agonistic autoantibodies to the angiotensin II type I (AT1-AA) receptor during pregnancy, Experimental Biology, Virtual | 04/2021 |
| Platform Presentations, Administration of MIP3-alpha neutralization antibody reduces the renal infiltration of dendritic cells and Th17s and attenuates progressive proteinuria in obese Dahl salt-sensitive rats, Experimental Biology, Virtual | 04/2021 |
| Platform Presentations, NLRP3 plays a causative role in vascular and renal dysfunction in hypertension in placental ischemic pregnancy, Experimental Biology, Virtual | 04/2021 |
| Platform Presentations, Neutralization of Natural Killer Cell associated cytokines improves vascular function and reduced blood pressure in placental ischemic rats, Experimental Biology, Virtual | 04/2021 |
| Platform Presentations, AT1-AAs cause vascular endothelial mitochondrial oxidative stress associated with Preeclampsia, Experimental Biology, Virtual | 04/2021 |
| Platform Presentations, Placental Ischemia Stimulated Natural Killer Cells Play a Direct Role in Causing Hypertension and Intrauterine Growth Restriction in Pregnant Rats, Experimental Biology, Virtual | 04/2021 |
| State/Local Invited Seminars/Lectures, Black in Biology Panel, Jackson State University Biological Society, Jackson, MS | 02/2021 |
| Platform Presentations, IL-17 stimulates B cells to secrete AT1-AA in hypertension and multi-organ tissue dysfunction during pregnancy, Society of Maternal Fetal Medicine Annual Meeting, Virtual | 01/2021 |
| Regional Invited Seminars/Lectures, Maintaining Maternal Balance: Adaptive-Innate Crosstalk in Preeclampsia, Meharry Medical College, Nashville, TN | 10/2020 |
| Poster Presentation, Treatment with IL-25 slows the early progression of proteinuria in obese Dahl Salt-Sensitive rats, American Heart Association Council on Hypertension Fall Specialty Conference, Virtual | 09/2020 |
| Poster Presentation, Placental ischemia-stimulated natural killer cells contribute to hypertension, vascular dysfunction, and intrauterine growth restriction in pregnant rats, American Heart Association Council on Hypertension Fall Specialty Conference, Virtual | 09/2020 |
| Poster Presentation, Mitochondrial dysfunction And natural killer cell activation stimulated by IL-17 signaling from Th17 cells in response to placental ischemia during pregnancy, American Heart Association Council on Hypertension Fall Specialty Conference, Virtual | 09/2020 |
| National and International Invited Seminars/Lectures, Restarting a Lab or Research Project During a Pandemic, American Heart Association, Online Webinar | 07/2020 |
| Poster Presentation, Placental Ischemia Stimulated Natural Killer Cells Play a Direct Role in Causing Hypertension and Intrauterine Growth Restriction in Pregnant Rats, Experimental Biology, Virtual | 04/2020 |
| Poster Presentation, IL-17 signaling mediates cytolytic natural killer cell activation in placental-ischemic rats., Experimental Biology, Virtual | 04/2020 |
| Poster Presentation, Progesterone induced blocking factor improves blood pressure, mitochondrial dysfunction, and reactive oxygen species in response to sFlt-1 induced hypertension during pregnancy, Experimental Biology, Virtual | 04/2020 |
| Poster Presentation, The early progression of renal injury in obese Dahl Salt-Sensitive rats is associated with increased M2 macrophage infiltration, `Experimental Biology, Virtual | 04/2020 |
| Platform Presentations, The role of NLRP3 inflammasome in sepsis-induced multi-organ injury., Mississippi Academy of Science Annual Meeting, Biloxi, MS | 02/2020 |
| Poster Presentation, IL-17 signaling mediates cytolytic natural killer cell activation in response to placental ischemia, Council on Hypertension Scientific Sessions, New Orleans, LA | 09/2019 |
| Platform Presentations, Cytolytic natural killer cells play a direct role in causing hypertension and intrauterine growth restriction in pregnant rats, Council on Hypertension Scientific Sessions, New Orleans, LA | 09/2019 |
| Poster Presentation, Inhibition of NLRP3 activation attenuates platelet activation and decreases multi-organ injury in response to abdominal sepsis, 42nd Annual Conference on Shock 2019, Coronado, CA | 06/2019 |
| Poster Presentation, Suppression of TH17 cells blunts preeclampsia-associated cytolytic natural killer cells during pregnancy, Experimental Biology, Orlando, FL | 04/2019 |
| Poster Presentation, Interleukin-4 supplementation improves the pro-inflammatory ratios, autoantibodies, and blood pressure in response to placental ischemia, Experimental Biology, Orlando, FL | 04/2019 |
| Poster Presentation, Depletion of macrophages with clodronate partially reduces the progression of renal injury in obese Dahl salt-sensitive rats during prepubertal obesity, Experimental Biology, Orlando, FL | 04/2019 |
| Platform Presentations, Platelet inhibition prevents NLRP3 inflammasome activation and sepsis-induced multi-organ injury, 48th Critical Care Congress, San Diego, CA | 02/2019 |
| Platform Presentations, Etanercept improves Natural Killer Cell activation and hypertension in a preclinical rat model of Pre-eclampsia, Society for Maternal Fetal Medicine 2019, Las Vegas, NV | 02/2019 |
| Poster Presentation, Progesterone induced blocking factor improves clinical characteristics of preeclampsia in RUPP rats, Council on Hypertension Scientific Sessions, Chicago, IL | 09/2018 |
| Poster Presentation, Early renal hyperfiltration in obese Dahl salt-sensitive leptin receptor mutant rats is associated with glomerular leukocyte extravasation and renal disease, Council on Hypertension Scientific Sessions, Chicago, IL | 09/2018 |
| Platform Presentations, Interleukin-17 mediates hypertension, intrauterine growth restriction, cytolytic natural killer Cells and Vascular Dysfunction in Pregnant Rats, Council on Hypertension Scientific Sessions, Chicago, IL | 09/2018 |
| Poster Presentation, Stimulation of NLRP3 inflammasome assembly in activated platelets in response to abdominal sepsis, 41st Annual Meeting on Shock, Scottsdale, AZ | 06/2018 |
| Platform Presentations, Phosphatidylserine expressing platelet microparticles predict sepsis mortality and correlates with thrombocytopenia, Society for Academic Emergency Medicine Annual Meeting, Indianapolis, IN | 05/2018 |
| Platform Presentations, Sex differences in the development of renal injury in obese Dahl salt-sensitive leptin receptor mutant rants during prepubertal obesity, Experimental Biology, San Diego, CA | 04/2018 |
| Platform Presentations, The role of mitochondrial oxidative stress in the pathophysiology of preeclampsia, Experimental Biology, San Diego, CA | 04/2018 |
| Poster Presentation, Role of cerebral vascular dysfunction in Alzheimer-like cognitive deficits in diabetic T2DN rats, Experimental Biology, San Diego, CA | 04/2018 |
| Poster Presentation, The role of interleukin-2 (IL-2) in Natural Killer Cell (NK) activation and hypertension in a preclinical rat model of preeclampsia, Experimental Biology, San Diego, CA | 04/2018 |
| Poster Presentation, Sex differences in the development of renal injury in obese Dahl salt-sensitive leptin receptor mutant rants during prepubertal obesity, Experimental Biology, San Diego, CA | 04/2018 |
| Poster Presentation, Progesterone induced blocking factor improves fetal growth restriction possibly by reducing inflammation and placental cytolytic NK cells in response to placental ischemia during pregnancy, Experimental Biology, San Diego, CA | 04/2018 |
| Poster Presentation, The role of mitochondrial oxidative stress in the pathophysiology of preeclampsia, Experimental Biology, San Diego, CA | 04/2018 |
| Poster Presentation, Placental ischemia stimulated TH17 cells induce preeclampsia associated cytolytic natural killer cells during pregnancy, Experimental Biology, San Diego, CA | 04/2018 |
| Poster Presentation, The potential neuroprotective role of 20-HETE in association with its receptor GPR75 expression in hypertension, Eicosanoid Research Association, Inc, Baltimore, MD | 03/2018 |
| Poster Presentation, Platelet activation is associated with pulmonary edema and renal injury in a rat model of polymicrobial sepsis., Council on Hypertension, San Francisco, CA | 09/2017 |
| Poster Presentation, Placental ischemia-stimulated TH17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy., Council on Hypertension, San Francisco, CA | 09/2017 |
| Poster Presentation, Circulating factors in response to placental ischemia cause vascular endothelial mitochondrial oxidative stress, Council on Hypertension Scientific Sessions, San Francisco, CA | 09/2017 |
| Poster Presentation, Interleukin-4 supplementation improves chronic inflammation and hypertension in response to placental ischemia during pregnancy, Council on Hypertension Scientific Sessions, San Francisco, CA | 09/2017 |
| Poster Presentation, Preeclamptic placental CD4+ T cells cause preeclamptic like features in normal pregnant nude athymic rats, Council on Hypertension Scientific Sessions, San Francisco, CA | 09/2017 |
| Poster Presentation, Natural killer cells contribute to placental mitochondrial dysfunction in response to placental ischemia in reduced uterine perfusion pressure (RUPP) rat model of preeclampsia, APS Conference: Physiological Bioenergetics: Mitochondria from Bench to Bedside, San Diego, CA | 08/2017 |
| Poster Presentation, Natural Killer Cells Stimulated in Response to Placental Ischemia Mediate Hypertension, Intrauterine Growth Restriction, and Inflammation during Pregnancy, Experimental Biology 2017, Chicago, IL | 04/2017 |
| Platform Presentations, Natural Killer Cells Stimulated in Response to Placental Ischemia mediate Hypertension, Intrauterine Growth Restriction, and Inflammation during Pregnancy, Experimental Biology, Chicago, IL | 04/2017 |
| Platform Presentations, Natural Killer Cells Stimulated in Response to Placental Ischemia Mediate Hypertension, Intrauterine Growth Restriction, and Inflammation during Pregnancy, Experimental Biology 2017, Chicago, IL | 04/2017 |
| Poster Presentation, 17-hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing inflammation and placental cytolytic NK cells in response to placental ischemia during pregnancy, Experimental Biology, Chicago, IL | 04/2017 |
| Poster Presentation, Inhibition of Angiotensin II Type 1 Receptor Agonistic Autoantibody binding Improves Maternal Outcomes in Rats with Placental Ischemia, Experimental Biology, Chicago, IL | 04/2017 |
| Poster Presentation, Role of Natural Killer Cells as Mediators of Mitochondrial Dysfunction Induced by Placental Ischemia in the Reduced Uterine Perfusion Pressure (RUPP) Rat Model of Preeclampsia, Experimental Biology, Chicago, IL | 04/2017 |
| Platform Presentations, Role of Natural Killer Cells as Mediators of Mitochondrial Dysfunction Induced by Placental Ischemia in the Reduced Uterine Perfusion Pressure (RUPP) Rat Model of Preeclampsia, Experimental Biology, Chicago, IL | 04/2017 |
| Platform Presentations, Investigation of platelet microparticle (PMP) concentrations in patients with infectious (septic) shock as a potential indicator of prognosis, UMMC, Jackson, MS | 04/2017 |
| Poster Presentation, A role Natural Killer cells in the pathophysiology of preeclampsia, Society for Maternal Fetal Medicine, Las Vegas, NV | 01/2017 |
| Platform Presentations, NK cells play an important role in placental ischemia induced mitochondrial dysfunction in Reduced Uterine Perfusion Pressure (RUPP) rats, Pharmacology, London, UK | 11/2016 |
| Platform Presentations, 17-hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing sFlt-1 and placental cytolytic NK cells in the Reduced Uterine Perfusion Pressure (RUPP) rat model of preeclampsia, International Society for the Study of Hypertension in Pregnancy, Sao, Paulo, Brazil | 10/2016 |
| Platform Presentations, Depletion of natural killer cells activated in response to placental ischemia improves hypertension and IUGR during pregnancy, American Heart Association Council on Hypertension, Orlando, FL | 09/2016 |
| Platform Presentations, 17-hydroxyprogesterone caproate improves and placental cytolytic NK cells in response to placental ischemia during pregnancy, Council on Hypertension Scientific Sessions, Orlando, FL | 09/2016 |
| Platform Presentations, Metabolic Syndrome and the Pathway of Drug Development From Bench to Bedside, Experimental Biology, San Diego, CA | 04/2016 |
| State/Local Invited Seminars/Lectures, Her Scientific Methods and Madness, Mississippi EPSCoR Program, Tougaloo College | 01/2016 |
| Poster Presentation, Vitamin D Supplementation Inhibits Blood Pressure and Uterine Artery Resistance Induced by Autoantibodies to the AT1 Receptor, American Physiological Society Conference on Cardiovascular, Renal, and Metabolic Diseases: Physiology and Gender, Annapolis, MD | 11/2015 |
| Platform Presentations, A role for IL-17 to activate cytolytic natural killer cells in response to placental ischemia, American Heart Association Council on Hypertension, Washington, DC | 09/2015 |
| Platform Presentations, Early administration of 17-hydroxyprogesterone caproate improves fetal growth restriction possibly by reducing sFLT-1 and placental cytolytic NK cells in response to placental ischemia during pregnancy, Council on Hypertension Scientific Sessions, Washington, DC | 09/2015 |
| Poster Presentation, Inhibition of AT1-AAs by direct binding reduces blood pressure and natural killer cell activation in response to placental ischemia of pregnancy; emphasizing the importance of novel drug development in the treatment of preeclampsia, Council on Hypertension Scientific Sessions, Washington, DC | 09/2015 |
| Poster Presentation, T Cell-Dependent B cell Activation Mediates Pathophysiology in Response to CD4+ T Cells from reduced Uterine Perfusion Pregnant Rats, Federation of American Societies of Experimental Biology, Boston, MA | 03/2015 |
| Poster Presentation, Early administration of 17-hydroxyprogesterone caproate to reduced uterine perfusion pressure (RUPP) rat model of preeclampsia improves inflammation, uterine artery vasoconstriction and blood pressure during pregnancy, Experimental Biology, Boston, MA | 03/2015 |
| Poster Presentation, Agonistic autoantibodies to the angiotensin II type I receptor enhance ANGII binding on vascular endothelial cells, Experimental Biology, Boston, MA | 03/2015 |
| Platform Presentations, Placental Ischemia-Induced TH17 Cells Mediate the Pathophysiology Associated with Preeclampsia, Federation of American Societies for Experimental Biology, Boston, MA | 03/2015 |
| Poster Presentation, Placental Ischemia-Induced TH17 Cells Mediate the Pathophysiology Associated with Preeclampsia, Federation of American Societies for Experimental Biology, Boston, MA | 03/2015 |
| Platform Presentations, Agonistic autoantibodies to the angiotensin II type I receptor enhance ANGII binding on vascular endothelial cells, Experimental Biology, Boston, MA | 03/2015 |
| Platform Presentations, A Role for TH17 cells and IL-17 in Mediating the Pathophysiology Associated with Preeclampsia, the International Society for the Study of Hypertension in Pregnancy, New Orleans, LA | 10/2014 |
| Platform Presentations, Pregnant Nude-Athymic Rats Experience Preeclampsia-Like Pathophysiology When Exposed to CD4+ T Cells isolated from preeclamptic Women, International Society for the Study of Hypertension in Pregnancy, New Orleans, LA | 10/2014 |
| Platform Presentations, Treatment with Vitamin D attenuates blood pressure and immune activation in a preeclamptic rat model, International Society for the Study of Hypertension in Pregnancy, New Orleans, LA | 10/2014 |
| Platform Presentations, 17-hydroxyprogesterone caproate attenuates hypertension and uterine artery resistance in response to reduced uterine perfusion pressure in (RUPP) in pregnant rats, International Society for the Study of Hypertension in Pregnancy, New Orleans, LA | 10/2014 |
| Platform Presentations, T cell-dependent B cell activation plays a role in mediating hypertension and pathophysiology in response to CD4+ T cell from reduced uterine perfusion pressure pregnant rats, American Heart Association High Blood Pressure Council, San Francisco, CA | 09/2014 |
| Poster Presentation, Vitamin D supplementation reduces CD4+ T cells, blood pressure and autoantibodies to the AT1 receptor (AT1-AA) in a rat model of preeclampsia, Council on Hypertension Scientific Sessions, San Francisco, CA | 09/2014 |
| Poster Presentation, Proliferation of endogenous T-reg cells improves the pathophysiology associated with placental ischemia of pregnancy, High Blood Pressure Council Scientific Sessions, San Francisco, CA | 09/2014 |
| Poster Presentation, CD4+ T cells isolated from preeclamptic women produce a preeclampsia-like phenotype in nude-athymic rats, High Blood Pressure Council Scientific Sessions, San Francisco, CA | 09/2014 |
| Platform Presentations, Progesterone supplementation improves blood pressure and uterine artery resistance in response to placental ischemia during pregnancy, High Blood Pressure Council Scientific Sessions, San Francisco, CA | 09/2014 |
| Platform Presentations, Normal pregnant T Regs inhibit pathophysiology associated with hypertension in response to Reduced Uterine Perfusion Pressure (RUPP) in pregnant rats, Federation of American Societies of Experimental Biology, San Diego, CA | 04/2014 |
| Poster Presentation, Normal pregnant T Regs inhibit pathophysiology associated with hypertension in response to Reduced Uterine Perfusion Pressure (RUPP) in pregnant rats, Federation of American Societies of Experimental Biology, San Diego, CA | 04/2014 |
| Poster Presentation, IL-10 supplementation suppressed hypertension and inflammation in response to placental ischemia during pregnancy, Experimental Biology, San Diego, CA | 04/2014 |
| Platform Presentations, IL-10 supplementation suppressed hypertension and inflammation in response to placental ischemia during pregnancy, Experimental Biology, San Diego, CA | 04/2014 |
| Poster Presentation, Specific Inhibition of AT1-AAs by direct binding improves maternal and fetal outcome in response to placental ischemia during pregnancy; emphasizing the importance of novel drug development in the treatment of preeclampsia, Experimental Biology, San Diego, CA | 04/2014 |
| Poster Presentation, Oxidative stress signaling in response to CD4+T cells stimulated via placental ischemia plays an important role in hypertension during preeclampsia, Experimental Biology, San Diego, CA | 04/2014 |
| Poster Presentation, Inhibition of AT1-AAs by interrupting lymphocyte communication or by direct binding reduces blood pressure in response to placental ischemia of pregnancy; emphasizing the importance of novel drug development in the treatment of preeclampsia, Society for Maternal Fetal Medicine, New Orleans, LA | 02/2014 |
| Platform Presentations, Reduced uterine perfusion pressure T-helper 17 cells cause hypertension and IUGR during pregnancy, American Heart Association Council for High Blood Pressure Research, New Orleans, LA | 09/2013 |
| Platform Presentations, Progesterone supplementation attenuates hypertension and AT1-AA in response to elevated IL-6 during pregnancy, American Heart Association Council on Hypertension Scientific Sessions, New Orleans | 09/2013 |
| Poster Presentation, Blunting circulating TH17 cells decreases hypertension and oxidative stress in response to placental Ischemia, Federation of American Societies of Experimental Biology, Boston, MA | 04/2013 |
| Poster Presentation, Infusion of IL-17 blocking protein blunts hypertension and oxidative stress in response to placental ischemia, Society for Gynecologic Investigation, Orlando, FL | 03/2013 |
| State/Local Invited Seminars/Lectures, The Use of Multilocus Sequence Typing to Elucidate the Evolutionary Biology of Trichomonas vaginalis, American Society of Microbiology- Mississippi College Chapter, Clinton, MS | 03/2012 |
| Poster Presentation, Genetic characterization, metronidazole susceptibility testing, and secreted protease activity of clinical Trichomonas vaginalis (T. vaginalis) isolates, Annual Biomedical Research Conference for Minority Students, St. Louis, MO | 11/2011 |
| Poster Presentation, Genetic and virulence characterization of Trichomonas vaginalis isolates, UMMC Graduate Research Day, Jackson, MS | 10/2011 |
| Poster Presentation, Genetic characterization, metronidazole susceptibility testing, and secreted protease activity in clinical trichomonas vaginalis isolates, Eighth International Symposium on Recent Advances in Environmental Health Research, Jackson, MS | 09/2011 |
| Poster Presentation, Genetic characterization, metronidazole susceptibility testing, and secreted protease activity of historical and clinical Trichomonas vaginalis Isolates, American Society of Tropical Medicine and Hygiene, Atlanta, GA | 11/2010 |
| Platform Presentations, Genetics, Drug Resistance, and Virulence in Trichomonas vaginalis, University of Mississippi Medical Center School of Graduate Studies in the Health Sciences, Jackson, MS | 10/2010 |
| Poster Presentation, Genetic characterization and metronidazole susceptibility testing of historical and clinical Trichomonas vaginalis isolates, University of Mississippi Medical Center School of Graduate Studies in the Health Sciences, Jackson, MS | 10/2009 |
| Poster Presentation, MCF-7 breast cancer cells down-regulate macrophage migration inhibitory factor in co-cultured macrophages: implications for context-specific modulation of tumor-associated macrophages, U.S. Department of Defense Era of Hope Meeting, Baltimore, MD | 06/2008 |
| Poster Presentation, Breast cancer cells down-regulate tristetraprolin in co-cultured macrophages: A possible mechanism for sustaining inflammation and angiogenesis in the tumor microenvironment, U.S. Department of Defense Era of Hope, Baltimore, MD | 06/2008 |
| Poster Presentation, Transcriptional regulation of bcl-2 in proliferating epidermal keratinocytes by AP-1, American Association for Cancer Research, Los Angeles, CA | 04/2007 |
| Poster Presentation, The regulation of tristetraprolin expression in tumor-associated macrophages by breast cancer cells, Howard University College of Arts and Sciences, Washington, DC | 03/2006 |
| Platform Presentations, Topical Cholesterol as an effective treatment for pneumococcus keratitis, Ocular Microbiology and Immunology Group Meeting, Chicago, IL | 10/2005 |
Honors, Awards, and Recognition
| 2022-2023 Mid-Career Faculty Award, UMMC Chapter of the AAMC Group on Women in Medicine and Science | 2023 |
| 2021 Paul Dudley White International Scholar, American Heart Association Council on Hypertension | 2021 |
| 37th Daniel T Rolfe Scholars Memorial Heritage Lecturer, Meharry Medical College School of Medicine and School of Graduate Studies and Research | 2020 |
| University of Mississippi Medical Center Gold Excellence in Research Award, University of Mississippi Medical Center | 2020 |
| Water and Electrolyte Homeostasis Section Data Sciences International New Investigator Award, American Physiological Society | 2020 |
| GWIMS Rising Star Award, Group on Women in Medicine and Science | 2020 |
| Silver Research Excellence Award, University of Mississippi Medical Center | 2019 |
| Early Career Investigator Award, University of Mississippi Medical Center | 2019 |
| Fellow, American Heart Association | 2019 |
| Bronze Research Excellence Award, University of Mississippi Medical Center | 2018 |
| Service Recognition to HBCU Scholar Program, American Heart Association | 2018 |
| Best of American Heart Association (AHA) Specialty Conferences Poster Award, American Heart Association | 2015 |
| Council on Hypertension New Investigator Award, American Heart Association | 2015 |
| Physiologists in Industry Committee Novel Disease Model Postdoctoral Award, American Physiological Society | 2015 |
| Best of American Heart Association (AHA) Specialty Conferences Poster Award, American Heart Association | 2014 |
| Annual High Blood Pressure Research Conference Top Trainee Abstract Award, American Heart Association | 2014 |
| Annual High Blood Pressure Research Conference New Investigator Award, American Heart Association | 2014 |
| Steven M. Horvath Professional Opportunity Award, American Physiological Society | 2014 |
| Mid-Career Faculty Award, UMMC Chapter of the AAMC Group on Women in Medicine and Science | 2013 |
| APS/NIDDK Minority Travel Award Fellow, American Physiological Society/ NIDDK | 2013 |
| Water and Electrolyte Homeostasis Postdoctoral Research with Distinction Award, American Physiological Society | 2013 |
| Student Certificate of Progress Department of Microbiology, University of Mississippi Medical Center | 2011 |
| UNCF-Merck Graduate Science Research Dissertation Fellowship, United Negro College Fund- Merck Science Initiative | 2010 |
| Higher Education Appreciation Day, Working for Academic Excellence (HEADWAE) Award, Mississippi Public Universities | 2010 |
| School of Graduate Studies in the Health Science Graduate Research Day Poster Award, University of Mississippi Medical Center | 2009 |
| Dean's Scholarship, University of Mississippi Medical Center School of Graduate Studies in Health Sciences | 2008 |
Professional Membership and Service
| Society of Reproductive Investigation, Member, Annual Meeting of the Society for Reproductive Investigation | 2022 - Present |
| Shock Society, Member, Annual Conference on Shock | 2016 - 2022 |
| Society of Academic Emergency Medicine, Member, SAEM Annual Meeting | 2015 - 2017 |
| American Heart Association, Fellow, Council on Hypertension Scientific Sessions; AHA HBCU Scholar's Program- Mentor for undergraduate students to have meaningful research experience began in 2018 | 2013 - Present |
| American Physiological Society, Member, Experimental Biology- Water and Electrolyte Homeostasis Mentoring on the Go Program, Mentor for APS Minority Travel Award Fellows | 2012 - Present |
| American Society of Tropical Medicine and Hygiene, Member, American Society of Tropical Medicine and Hygiene Annual Meeting | 2010 - 2012 |
Committee Service
| SCHOOL OF MEDICINE-FACULTY APPOINTMENTS, PROMOTIONS AND TENURE, Member | 2022 - Present |
| Federation of American Societies for Experimental Biology Board of Directors, Member | 2022 - Present |
| Department of Emergency Medicine Promotions and Tenure Committee, Member | 2022 - 2022 |
| American Heart Association Council on Hypertension Leadership Committee, Member | 2021 - Present |
| MEDICAL CENTER-RESEARCH ADVISORY, Member | 2021 - Present |
| Research Compliance Management, Member | 2021 - Present |
| Emergency Medicine Diversity, Equity, Inclusion Planning Committee, Member | 2020 - Present |
| Editor Search Committee for Hypertension Journal, Member | 2020 - 2021 |
| American Heart Association Hypertension Fall Specialty Conference Planning Committee of the Council on Hypertension, Member | 2020 - Present |
| Group on Women in Medicine and Science Executive Board, Steering Comittee Member | 2020 - 2021 |
| School of Medicine Discovery Curriculum Committee, Member | 2020 - Present |
| MEDICAL CENTER-INSTITUTIONAL BIOSAFETY, Vice Chair | 2019 - 2022 |
| American Physiological Society Finance Committee, Member | 2019 - Present |
| Group on Women in Medicine and Science Membership Committee, Member | 2018 - 2020 |
| Group on Women in Medicine and Science Mentoring Committee, Member | 2018 - 2019 |
| American Heart Association Hypertension Membership and Communications Committee, Member | 2017 - 2020 |
| The American Physiological Society Water and Electrolyte Homeostasis Section, Steering Comittee Member | 2017 - 2020 |
| MEDICAL CENTER-INSTITUTIONAL BIOSAFETY, Member | 2017 - 2019 |
| Advisory Committee for Office of Postdoctoral Studies in Graduate School of Biomedical Sciences, Member | 2014 - 2016 |
| University of Mississippi Medical Center Hospitality Committee, Member | 2009 - 2010 |
Community Service
| Hopkins County Detention Center, Volunteer Minister | 05/2022 - Present |
| Habitat for Humanity, Volunteer | 11/2021 - Present |
| Science Fair Judge at Michelle Obama Early College High School, Judge | 03/2019 - Present |
| Local and Regional High School Science Fair, Judge | 01/2019 - Present |
| Glory Revival Center, Praise and Worship Leader | 05/2017 - Present |
| Discovery U, Volunteer | 01/2016 - 01/2016 |
| Physiology Understanding Week, Volunteer | 10/2013 - 11/2018 |
| Glory Revival Center, Board Member | 04/2013 - Present |
| Spirit Life Training Center, Volunteer | 04/2013 - 08/2017 |
| Local and Regional Middle and High School Science Fairs, Judge | 2012 - Present |
| Gleaners, Inc., Volunteer | 2009 - 12/2011 |
| New McRaven Hill M.B. Church, Choreographer | 11/2005 - 05/2008 |
| Friendship Praise and Worship Center, Choreographer | 10/2003 - 05/2010 |
Other Service
| NIH Environmental Determinants of Disease Study Section Standing Member | 07/2022 - Present |
| Graduate Women in Science (GWIS) National Fellowship Program | 06/2022 - 06/2022 |
| NIH- Systemic Injury by Environemental Exposures (SIEE) Study Section | 09/2021 - 07/2022 |
| NIH Image Guided Interventions and Surgery (IGIS) Study Section | 06/2021 - 06/2021 |
| Chair, Clinical Fellowship Review Panel, American Heart Association, Chair | 04/2021 - Present |
| NIH Renal/Urological Sciences Small Business Activities Special Emphasis Panel (SBIR) | 02/2021 - 02/2021 |
| Co-Chair, Career Development Award Clinical 1 Review Panel, American Heart Association, Co-Chair | 2021 - 02/2021 |
| Co-Chair, Clinical Fellowship Review Panel,American Heart Association, Co-Chair | 12/2020 - 03/2021 |
| NIH Hypertension and Microcirculation Study Section | 02/2020 - 02/2020 |
| UNMC Center for Heart and Vascular Research Pilot Program (in collaboration with the Great Plains IDeA-CTR) | 11/2019 - Present |
| American Heart Association, Transformative Project Award- Basic Sciences | 2019 - 12/2019 |
| American Journal of Physiology-Heart and Circulatory Physiology | 2019 - Present |
| Immunologic Research | 2019 - Present |
| Life Sciences | 2019 - Present |
| Gene | 2019 - Present |
| International Journal of Molecular Sciences | 2019 - Present |
| Hypertension in Pregnancy | 2019 - Present |
| Pharmacological Reports | 2019 - Present |
| Human Immunology | 2019 - Present |
| American Heart Association, Innovative Project Award Program | 2018 - 12/2018 |
| Oxidative Medicine and Cellular Longevity | 2018 - Present |
| Journal of Hypertension | 2018 - Present |
| International Journal of Developmental Neuroscience | 2018 - Present |
| Heliyon | 2018 - Present |
| Evidence Based Complementary and Alternative Medicine | 2018 - Present |
| Journal of Thoracic Disease | 2018 - Present |
| Cardiology Research | 2018 - Present |
| Canadian Journal of Physiology and Pharmacology | 2018 - Present |
| BMC Pregnancy and Childbirth | 2018 - Present |
| Brazilian Journal of Medical and Biological Research | 2018 - Present |
| American Journal of Tropical Medicine and Hygiene | 2018 - Present |
| American Journal of Pathology | 2018 - Present |
| Kabala International Journal of Modern Science | 2018 - Present |
| Medical Journal of Obstetrics and Gynecology | 2018 - Present |
| Biomarker Insights | 12/2017 - Present |
| Innate Immunity | 11/2017 - Present |
| Journal of Diabetes Research | 11/2017 - Present |
| Disease Markers | 04/2017 - Present |
| The American Physiological Society Porter Minority Travel Fellowship, Mentor | 04/2017 - Present |
| The American Physiological Society Water Electrolyte and Homeostasis Section, Mentor | 04/2017 - Present |
| Clinical Microbiology Reviews | 03/2017 - Present |
| American Heart Association, Vascular Endothelial Biology/Clinical Review Panel | 03/2017 - 10/2019 |
| Journal of Intensive Care Medicine | 02/2017 - Present |
| Archives of Emergency Medicine and Critical Care | 02/2016 - Present |
| BMJ Open | 01/2016 - Present |
| European Journal of Obstetrics and Gynecology and Reproductive Biology, Ad Hoc Reviewer | 01/2016 - Present |
| Scandinavian Journal of Immunology, Ad Hoc Reviewer | 10/2015 - Present |
| Microbiological Insights | 02/2015 - Present |
| Libertas Academica | 2015 - Present |
| Graduate School of Biomedical Sciences, Recruiter | 2014 - 12/2014 |
| Circulation | 2014 - Present |
| Hypertension | 2014 - Present |
| School of Dentistry, Tutor of Dental Microbiology | 09/2011 - 05/2012 |
| School of Medicine, Tutor | 09/2010 - 05/2012 |
Teaching Experience
| Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2022 |
| Dentistry, Course, Lecturer, Fundamentals of Pharmacology | Spring 2022 |
| ID714, Graduate, Course, Lecturer, Professional Skills | Spring 2022 |
| Medicine, Course, Lecturer, Medical Pharmacology | Fall 2021 |
| Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2021 |
| Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2020 |
| Medicine, Course, Lecturer, Medical Pharmacology | Fall 2020 |
| Medicine, Lecture, Lecturer, Emergency Medicine Residency Conference | Annual 2020 |
| ID714, Graduate, Course, Lecturer, Professional Skills | Spring 2020 |
| PHARM724, Graduate, Course, Lecturer, Experimental Design and Methods | Spring 2020 |
| Medicine, Lecture, Lecturer, Emergency Medicine Residency Conference | Annual 2019 |
| PHARM724, Graduate, Course, Lecturer, Experimental Design and Methods | Spring 2019 |
| Medicine, Course, Lecturer, Medical Pharmacology | Fall 2019 - 2019 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2019 |
| ID714, Graduate, Course, Lecturer, Professional Development | Spring 2019 |
| PHARM723, Graduate, Course, Lecturer, Mechanisms of Drug Actions | Spring 2019 |
| Medicine, Lecture, Lecturer, Emergency Medicine Residency Conference | Annual 2018 |
| Medicine, Course, Lecturer, Medical Pharmacology | Fall 2018 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2018 |
| Medicine, Lecture, Lecturer, Emergency Medicine Residency Conference | Annual 2017 |
| Medicine, Course, Lecturer, Medical Pharmacology | Spring 2017 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2017 - 2017 |
| Medicine, Course, Lecturer, Medical Pharmacology | Fall 2017 - 2017 |
| Medicine, Lecture, Lecturer, Emergency Medicine Residency Conference | Annual 2016 |
| Medicine, Course, Lecturer, Medical Pharmacology | Spring 2016 |
| Medicine, Course, Lecturer, Medical Pharmacology | Spring 2015 - 2015 |
| Medicine, Small Group, Facilitator, Medical Pharmacology | Fall 2014 - 2015 |
| Graduate, Course, Lecturer, MFM Research Tools in Molecular Biology | Spring 2014 - 2014 |
| Graduate, Course, Lecturer, Foundations of Neuroscience | Fall 2013 - 2014 |
| Graduate, Course, Lecturer, MFM Research Tools in Molecular Biology | Spring 2013 - 2014 |
| Medicine, Lab, Student Assistant, Medical Microbiology | Fall 2010 - 2011 |
Directed Student Learning
| Supervised Research, Advised: Jaylen Sandifer | 2022 - Present |
| Supervised Research, Advised: Candace Carter | 2022 - Present |
| Dissertation Committee Member, Insulin resistance-mediated renal macrophage inflammatory protein 3-alpha stimulates renal injury in pre-pubertal obesity. Advised: Ubong Ekperikpe | 2021 - Present |
| Supervised Research, Advised: Tatiana Davis | 2021 - 2021 |
| Supervised Research, Advised: Hannah Glenn, Christopher Nutter | 2021 - 2021 |
| Supervised Research, Advised: Olive Cooper, Rashauna Thomas | 2021 - 2021 |
| Dissertation Committee Chair, NLRP3 Inflammasome Signaling in Placental Ischemia-induced Pathophysiology Advised: Xi Wang | 2021 - Present |
| Research Advisor, Advised: La'Deira Hall | 2020 - 2021 |
| Dissertation Committee Member, The Role of B Lymphocytes in the Pathophysiology of Hypertension in Response to Placental Ischemia Advised: Owen Herrock | 2020 - Present |
| Dissertation Committee Member, The Role of TH17 cells and IL-17 in causing Mitochondrial Dysfunction in Response to Placental Ischemia and its Impact on the IUGR Offspring Advised: Sarah Fitzgerald | 2020 - Present |
| Supervised Research, Advised: Madison Crosby | 2020 - 2020 |
| Supervised Research, Advised: Henry Nguyen | 2020 - 2020 |
| Supervised Research, Advised: Shanni Siddiq | 2019 - 2021 |
| Supervised Research, Normal Placental Cells Attenuate Preeclampsia Symptoms in Response to Placental Ischemia Advised: Rachel Coleman | 2019 - 2021 |
| Supervised Research, Advised: David Fleming | 2019 - 2019 |
| Undergraduate Honors Thesis, Placental Ischemia-Stimulated Natural Killer Cells Induce Preeclampsia Pathophysiology in Pregnant Rats Advised: Carmilya Jackson | 2018 - 2019 |
| Supervised Research, Advised: Chanmee Seo | 2018 - 2020 |
| Research Advisor, Advised: Robert Tramel | 2018 - 2021 |
| Research Advisor, Advised: Mallory Greer | 2018 - 2018 |
| Supervised Research, Advised: Sumit Santakke | 2017 - 2017 |
| Supervised Research, Advised: Shaoxun Wang | 2017 - 2017 |
| Dissertation Committee Chair, A Role for Natural Killer Cells in the Pathophysiology of Hypertension and Intrauterine Growth Restriction during Pregnancy Advised: Olivia Travis | 2017 - 2021 |
| Dissertation Committee Member, Advised: Bibek Poudel | 2017 - 2021 |
| Supervised Research, Advised: Jeanne Ishimwe | 2017 - 2017 |
| Dissertation Committee Member, Advised: Corbin Shields | 2016 - 2021 |
| Supervised Research, Advised: Ashley Gnam | 2016 - 2017 |
| Undergraduate Honors Thesis, Platelet-Derived Microparticles and their role in sepsis Advised: Robert Tramel | 2016 - 2017 |
| Supervised Research, Advised: Jack Tharp | 2015 - 2015 |
| Supervised Research, Advised: Taia McAfee | 2015 - 2016 |
| Supervised Research, Advised: Tarek Ibrahim | 2014 - 2015 |
| Supervised Research, Advised: Jessica Faulkner | 2014 - 2015 |
| Supervised Research, Immune Suppression and AT1-AA Blockade: Novel Treatments for Preeclampsia Advised: Ashlyn Harmon | 2013 - 2015 |
| Supervised Research, Advised: Adrienne Paige | 2013 - 2014 |
| Supervised Research, Advised: Justin Porter | 2013 - 2013 |
| Supervised Research, Advised: Nathan Campbell | 2013 - 2015 |
| Supervised Research, Advised: Alexia Thomas | 2013 - 2014 |
| Supervised Research, Advised: Antrice Walker | 2011 - 2011 |
Fellows supervised
| Postdoctoral Fellowship, Post-Doc Advisor, 1 fellows supervised | 07/2021 - Present |
| Pediatric Intensive Care Unit Fellowship, Research Advisor, 1 fellows supervised, Research | 03/2018 - 06/2020 |
| Trauma Surgery, Training Faculty, 1 fellows supervised | 08/2017 - 06/2019 |
| Emergency Medicine, Training Faculty, 1 fellows supervised | 07/2016 - 06/2018 |
| MFM Fellowship Program, Supervised Research, 8 fellows supervised | 08/2012 - 06/2019 |
Residency Training
| Emergency Medicine, Research Advisor | 2021 - 06/2022 |
| Emergency Medicine Residency, Subspecialty/Activity Director | 2016 - Present |