Yingjie Chen

Yingjie Chen

Professor

Department:
SOM-Physiology & Biophysics

Email:
ychen2@umc.edu

Work Phone:
(601) 815-3987

Education

University of Minnesota, PhD, Kinisiology/Exercise Physiology1999
National Res Institute of Sports Science, MS, Exercise Physiology1991
Neimonggu Medical School, BS, Medicine1986
University of Minnesota Medical School, Postdoctoral fellow, Heart Failure Research
The 1st Teaching Hospital, Neimonggu Medical University, Neurosurgen, Neurosurgery

Current Positions

Professor, School of Medicine08/2019 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Professor, Tongji University, School of Medicine07/2015 - 07/2019
Associate Professor, University of Minnesota, School of Medicine, Department of Medicine07/2012 - 08/2019
Assistant Professor, University of Minnesota, School of Medicine07/2005 - 06/2012
Assistant Professor, University of Minnesota, School of Medicine07/2003 - 06/2005
Assistant Professor, University of Minnesota, School of Medicine07/2001 - 06/2003
Associate Professor, National Research Institute of Sports Science07/1993 - 08/1995
Department Chair, National Research Institute of Sports Science07/1993 - 08/1995
Assistant Professor, National Research Institute of Sports Science, School of Health Related Professions07/1991 - 06/1993
Neurosurgen, N, School of Medicine07/1986 - 06/1988

Sponsored Program Funding

Extramural, Mechanism of PD-1 in cardiomyopathy and heart failure progression, NIH04/2021 - 06/2026
Extramural, Mechanisms of Treg and IL-35 in Regulating LV Failure-induced Lung Remodeling and Right Heart Hypertrophy, NIH09/2018 - 06/2022
Extramural, CD44 in heart failure development and progression, American Heart Association07/2017 - 06/2019
Extramural, Effect of eIF4E3 on congestive heart failure development, American Heart Association07/2015 - 06/2017
Extramural, Molecular mechanism of 4E-binding proteins on heart failure development, NIH08/2011 - 06/2016
Extramural, Regulation of the novel mTOR suppressor DDIT4 in the failing heart, NIH04/2011 - 12/2014
Extramural, DDAH1 effects on endogenous NOS inhibitors and vascular endothelial function, NIH08/2010 - 06/2013
Extramural, DDAH1 effects on the development of congestive heart failure, NIH04/2010 - 03/2012
Extramural, AMP-activated protein kinase effects on ventricular hypertrophy and heart failure, American Heart Association07/2009 - 06/2011
Extramural, Effect of endothelial DDAH1 gene deletion on the development of left ventricular dysfunction, American Heart Association07/2009 - 10/2011
Extramural, Effect of NOS uncoupling on systolic overload-induced ventricular hypertrophy and congestive heart failure, American Heart Association07/2007 - 06/2009
Extramural, Myocardial perfusion in the hypertrophied heart, NIH07/2006 - 06/2011
Extramural, Myocardial perfusion in the hypertrophied heart05/2006 - 04/2010
Extramural, Effect of TMX67 on aortic banding-induced ventricular hypertrophy and congestive heart failure, TAP Pharmaceutical Products01/2005 - 06/2006
Extramural, Coronary Vascular Response to Ischemia, NIH07/2003 - 06/2008
Extramural, Nitric Oxide and Superoxide Effects on the Failing Heart, NIH07/2003 - 06/2007
Extramural, Effects of Nitric Oxide, Superoxide and Peroxynitrite on Myocardial Energy Metabolism in the Failing Heart, American Heart Association01/2003 - 12/2003
Extramural, Effects of Nitric Oxide and Peroxynitrite on Energy Metabolism in the Failing Heart, American Heart Association07/2001 - 12/2002
Extramural, Myocardial perfusion in the hypertrophied heart, NIH05/2001 - 04/2006

Publications

Journal Article

Ping Zhang, Xin Xu, Xinli Hu, Huan Wang, John Fassett, Yuqing Huo, Yingjie Chen, Robert J Bache DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis2013
Chen YJ, Guo QF. Delayed onset muscle damage J National Res Inst Sports Sci;1991;4:103-1111991
Shang L, Yue W, Wang D, Weng X, Hall ME, Xu Y, Hou M, Chen Y, Systolic overload-induced pulmonary inflammation, fibrosis, oxidative stress and heart failure progression through interleukin-1β. Journal of molecular and cellular cardiology, 2020 Sep;146:84-942020
Xu D, Ma M, Xu Y, Su Y, Ong SB, Hu X, Chai M, Zhao M, Li H, Chen Y, Xu X, Single-cell Transcriptome Analysis Indicates New Potential Regulation Mechanism of ACE2 and NPs signaling among heart failure patients infected with SARS-CoV-2. medRxiv : the preprint server for health sciences, 2020 May 15;2020
Weir EK, Thenappan T, Bhargava M, Chen Y, Does vitamin D deficiency increase the severity of COVID-19? Clinical medicine (London, England), 2020 Jul;20(4):e107-e1082020
Guo H, Xu D, Kuroki M, Lu Z, Xu X, Geurts A, Osborn JW, Chen Y, Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3. Free radical biology & medicine, 2020 May 20;152:787-7962020
Thenappan T, Khoruts A, Chen Y, Weir EK, Can intestinal microbiota and circulating microbial products contribute to pulmonary arterial hypertension? American journal of physiology. Heart and circulatory physiology, 2019 Nov 1;317(5):H1093-H11012019
Wang D, Li H, Weir EK, Xu Y, Xu D, Chen Y, Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. International journal of cardiology, 2019 Nov 15;295:14-202019
Shang L, Weng X, Wang D, Yue W, Mernaugh R, Amarnath V, Weir EK, Dudley SC, Xu Y, Hou M, Chen Y, Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling. Free radical biology & medicine, 2019 Sep;141:291-2982019
Somani A, Nair SL, Milbauer LC, Zhu G, Sajja S, Solovey A, Chen Y, Hebbel RP, Blood outgrowth endothelial cells overexpressing eNOS mitigate pulmonary hypertension in rats: a unique carrier cell enabling autologous cell-based gene therapy. Translational research : the journal of laboratory and clinical medicine, 2019 Aug;210:1-72019
Fassett J, Xu X, Kwak D, Zhu G, Fassett EK, Zhang P, Wang H, Mayer B, Bache RJ, Chen Y, Adenosine kinase attenuates cardiomyocyte microtubule stabilization and protects against pressure overload-induced hypertrophy and LV dysfunction. Journal of molecular and cellular cardiology, 2019 May;130:49-582019
Yue W, Tong L, Liu X, Weng X, Chen X, Wang D, Dudley SC, Weir EK, Ding W, Lu Z, Xu Y, Chen Y, Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy. Redox biology, 2019 Apr;22:1011612019
Liu X, Yang L, Kwak D, Hou L, Shang R, Meyer C, Panoskaltsis-Mortari A, Xu X, Weir EK, Chen Y, Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea. Journal of cardiovascular translational research, 2019 Aug;12(4):271-2792019
Liu X, Xu X, Shang R, Chen Y, Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease. Nitric oxide : biology and chemistry, 2018 Aug 1;78:113-1202018
Wang H, Shen X, Tian G, Shi X, Huang W, Wu Y, Sun L, Peng C, Liu S, Huang Y, Chen X, Zhang F, Chen Y, Ding W, Lu Z, AMPKα2 deficiency exacerbates long-term PM(2.5) exposure-induced lung injury and cardiac dysfunction. Free radical biology & medicine, 2018 Jun;121:202-2142018
Xu X, Zhang P, Kwak D, Fassett J, Yue W, Atzler D, Hu X, Liu X, Wang H, Lu Z, Guo H, Schwedhelm E, Böger RH, Chen P, Chen Y, Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction. Basic research in cardiology, 2017 Aug 17;112(5):552017
Wang H, Kwak D, Fassett J, Liu X, Yao W, Weng X, Xu X, Xu Y, Bache RJ, Mueller DL, Chen Y, Role of bone marrow-derived CD11c(+) dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy. Basic research in cardiology, 2017 May;112(3):252017
Zhang P, Fassett JT, Zhu G, Li J, Hu X, Xu X, Chen Y, Bache RJ, Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression. Vascular medicine (London, England), 2017 Jun;22(3):179-1882017
Wang L, Zhao XC, Cui W, Ma YQ, Ren HL, Zhou X, Fassett J, Yang YZ, Chen Y, Xia YL, Du J, Li HH, Genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular Dysfunction. Circulation, 2016 Nov 1;134(18):1353-13682016
Wang H, Kwak D, Fassett J, Hou L, Xu X, Burbach BJ, Thenappan T, Xu Y, Ge JB, Shimizu Y, Bache RJ, Chen Y, CD28/B7 Deficiency Attenuates Systolic Overload-Induced Congestive Heart Failure, Myocardial and Pulmonary Inflammation, and Activated T Cell Accumulation in the Heart and Lungs. Hypertension (Dallas, Tex. : 1979), 2016 Sep;68(3):688-962016
Wang H, Hou L, Kwak D, Fassett J, Xu X, Chen A, Chen W, Blazar BR, Xu Y, Hall JL, Ge JB, Bache RJ, Chen Y, Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure Progression. Hypertension (Dallas, Tex. : 1979), 2016 Jul;68(1):114-222016
Liu X, Hou L, Xu D, Chen A, Yang L, Zhuang Y, Xu Y, Fassett JT, Chen Y, Effect of asymmetric dimethylarginine (ADMA) on heart failure development. Nitric oxide : biology and chemistry, 2016 Apr 1;54:73-812016
Wang Y, Zhang P, Xu Z, Yue W, Zhuang Y, Chen Y, Lu Z, S-nitrosylation of PDE5 increases its ubiquitin-proteasomal degradation. Free radical biology & medicine, 2015 Sep;86:343-512015
Wang H, Xu X, Fassett J, Kwak D, Liu X, Hu X, Falls TJ, Bell JC, Li H, Bitterman P, Bache RJ, Chen Y, Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure. Circulation, 2014 Apr 1;129(13):1397-4062014
Liu X, Kwak D, Lu Z, Xu X, Fassett J, Wang H, Wei Y, Cavener DR, Hu X, Hall J, Bache RJ, Chen Y, Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling. Hypertension (Dallas, Tex. : 1979), 2014 Oct;64(4):738-442014
Lu Z, Xu X, Fassett J, Kwak D, Liu X, Hu X, Wang H, Guo H, Xu D, Yan S, McFalls EO, Lu F, Bache RJ, Chen Y, Loss of the eukaryotic initiation factor 2α kinase general control nonderepressible 2 protects mice from pressure overload-induced congestive heart failure without affecting ventricular hypertrophy. Hypertension (Dallas, Tex. : 1979), 2014 Jan;63(1):128-352014
Xu X, Lu Z, Fassett J, Zhang P, Hu X, Liu X, Kwak D, Li J, Zhu G, Tao Y, Hou M, Wang H, Guo H, Viollet B, McFalls EO, Bache RJ, Chen Y, Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2. Hypertension (Dallas, Tex. : 1979), 2014 Apr;63(4):723-82014
Jiang DS, Li L, Huang L, Gong J, Xia H, Liu X, Wan N, Wei X, Zhu X, Chen Y, Chen X, Zhang XD, Li H, Interferon regulatory factor 1 is required for cardiac remodeling in response to pressure overload. Hypertension (Dallas, Tex. : 1979), 2014 Jul;64(1):77-862014
Jiang DS, Liu Y, Zhou H, Zhang Y, Zhang XD, Zhang XF, Chen K, Gao L, Peng J, Gong H, Chen Y, Yang Q, Liu PP, Fan GC, Zou Y, Li H, Interferon regulatory factor 7 functions as a novel negative regulator of pathological cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979), 2014 Apr;63(4):713-222014
Chen Y, Zhang P, Li J, Xu X, Bache RJ, Inducible nitric oxide synthase inhibits oxygen consumption in collateral-dependent myocardium. American journal of physiology. Heart and circulatory physiology, 2014 Feb;306(3):H356-622014
Liu Y, Jiang XL, Liu Y, Jiang DS, Zhang Y, Zhang R, Chen Y, Yang Q, Zhang XD, Fan GC, Li H, Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice. Cardiovascular research, 2014 Jan 1;101(1):87-962014
Jiang DS, Bian ZY, Zhang Y, Zhang SM, Liu Y, Zhang R, Chen Y, Yang Q, Zhang XD, Fan GC, Li H, Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979), 2013 Jun;61(6):1193-2022013
Fassett JT, Hu X, Xu X, Lu Z, Zhang P, Chen Y, Bache RJ, AMPK attenuates microtubule proliferation in cardiac hypertrophy. American journal of physiology. Heart and circulatory physiology, 2013 Mar 1;304(5):H749-582013
Lu J, Bian ZY, Zhang R, Zhang Y, Liu C, Yan L, Zhang SM, Jiang DS, Wei X, Zhu XH, Chen M, Wang AB, Chen Y, Yang Q, Liu PP, Li H, Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy. Basic research in cardiology, 2013 Mar;108(2):3262013
Chen K, Gao L, Liu Y, Zhang Y, Jiang DS, Wei X, Zhu XH, Zhang R, Chen Y, Yang Q, Kioka N, Zhang XD, Li H, Vinexin-β protects against cardiac hypertrophy by blocking the Akt-dependent signalling pathway. Basic research in cardiology, 2013 Mar;108(2):3382013
Wang XA, Zhang R, Jiang D, Deng W, Zhang S, Deng S, Zhong J, Wang T, Zhu LH, Yang L, Hong S, Guo S, Chen K, Zhang XF, She Z, Chen Y, Yang Q, Zhang XD, Li H, Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice. Hepatology (Baltimore, Md.), 2013 Aug;58(2):603-162013
Cabrera JA, Butterick TA, Long EK, Ziemba EA, Anderson LB, Duffy CM, Sluiter W, Duncker DJ, Zhang J, Chen Y, Ward HB, Kelly RF, McFalls EO, Reduced expression of mitochondrial electron transport chain proteins from hibernating hearts relative to ischemic preconditioned hearts in the second window of protection. Journal of molecular and cellular cardiology, 2013 Jul;60:90-62013
Chen Y, Guo H, Xu D, Xu X, Wang H, Hu X, Lu Z, Kwak D, Xu Y, Gunther R, Huo Y, Weir EK, Left ventricular failure produces profound lung remodeling and pulmonary hypertension in mice: heart failure causes severe lung disease. Hypertension (Dallas, Tex. : 1979), 2012 Jun;59(6):1170-82012
Zhang W, Zhang X, Wang H, Guo X, Li H, Wang Y, Xu X, Tan L, Mashek MT, Zhang C, Chen Y, Mashek DG, Foretz M, Zhu C, Zhou H, Liu X, Viollet B, Wu C, Huo Y, AMP-activated protein kinase α1 protects against diet-induced insulin resistance and obesity. Diabetes, 2012 Dec;61(12):3114-252012
Bian ZY, Wei X, Deng S, Tang QZ, Feng J, Zhang Y, Liu C, Jiang DS, Yan L, Zhang LF, Chen M, Fassett J, Chen Y, He YW, Yang Q, Liu PP, Li H, Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. Journal of molecular medicine (Berlin, Germany), 2012 Aug;90(8):895-9102012
Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, Geurts AM, Ostertag E, Bache RJ, Weir EK, Chen Y, Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. Hypertension (Dallas, Tex. : 1979), 2011 Aug;58(2):303-92011
Hu X, Atzler D, Xu X, Zhang P, Guo H, Lu Z, Fassett J, Schwedhelm E, Böger RH, Bache RJ, Chen Y, Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arteriosclerosis, thrombosis, and vascular biology, 2011 Jul;31(7):1540-62011
Zhang P, Hu X, Xu X, Chen Y, Bache RJ, Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt. Arteriosclerosis, thrombosis, and vascular biology, 2011 Apr;31(4):890-72011
Hu X, Xu X, Lu Z, Zhang P, Fassett J, Zhang Y, Xin Y, Hall JL, Viollet B, Bache RJ, Huang Y, Chen Y, AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development. Hypertension (Dallas, Tex. : 1979), 2011 Oct;58(4):696-7032011
Fassett JT, Hu X, Xu X, Lu Z, Zhang P, Chen Y, Bache RJ, Adenosine kinase regulation of cardiomyocyte hypertrophy. American journal of physiology. Heart and circulatory physiology, 2011 May;300(5):H1722-322011
Yan L, Wei X, Tang QZ, Feng J, Zhang Y, Liu C, Bian ZY, Zhang LF, Chen M, Bai X, Wang AB, Fassett J, Chen Y, He YW, Yang Q, Liu PP, Li H, Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling. Cardiovascular research, 2011 Oct 1;92(1):85-942011
Lu Z, Xu X, Hu X, Fassett J, Zhu G, Tao Y, Li J, Huang Y, Zhang P, Zhao B, Chen Y, PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxidants & redox signaling, 2010 Oct 1;13(7):1011-222010
Lu Z, Xu X, Hu X, Lee S, Traverse JH, Zhu G, Fassett J, Tao Y, Zhang P, dos Remedios C, Pritzker M, Hall JL, Garry DJ, Chen Y, Oxidative stress regulates left ventricular PDE5 expression in the failing heart. Circulation, 2010 Apr 6;121(13):1474-832010
Solovey A, Kollander R, Milbauer LC, Abdulla F, Chen Y, Kelm RJ Jr, Hebbel RP, Endothelial nitric oxide synthase and nitric oxide regulate endothelial tissue factor expression in vivo in the sickle transgenic mouse. American journal of hematology, 2010 Jan;85(1):41-52010
Xu X, Zhao L, Hu X, Zhang P, Wessale J, Bache R, Chen Y, Delayed treatment effects of xanthine oxidase inhibition on systolic overload-induced left ventricular hypertrophy and dysfunction. Nucleosides, nucleotides & nucleic acids, 2010 Jun;29(4-6):306-132010
Hu X, Xu X, Zhu G, Atzler D, Kimoto M, Chen J, Schwedhelm E, Lüneburg N, Böger RH, Zhang P, Chen Y, Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine. Circulation, 2009 Dec 1;120(22):2222-92009
Fassett JT, Xu X, Hu X, Zhu G, French J, Chen Y, Bache RJ, Adenosine regulation of microtubule dynamics in cardiac hypertrophy. American journal of physiology. Heart and circulatory physiology, 2009 Aug;297(2):H523-322009
Nath N, Khan M, Rattan R, Mangalam A, Makkar RS, de Meester C, Bertrand L, Singh I, Chen Y, Viollet B, Giri S, Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Biochemical and biophysical research communications, 2009 Aug 14;386(1):16-202009
Zhang P, Hou M, Li Y, Xu X, Barsoum M, Chen Y, Bache RJ, NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart. American journal of physiology. Heart and circulatory physiology, 2009 Mar;296(3):H840-62009
Xu X, Hu X, Lu Z, Zhang P, Zhao L, Wessale JL, Bache RJ, Chen Y, Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. Journal of cardiac failure, 2008 Nov;14(9):746-532008
Zhang P, Hu X, Xu X, Fassett J, Zhu G, Viollet B, Xu W, Wiczer B, Bernlohr DA, Bache RJ, Chen Y, AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension (Dallas, Tex. : 1979), 2008 Nov;52(5):918-242008
Lu Z, Fassett J, Xu X, Hu X, Zhu G, French J, Zhang P, Schnermann J, Bache RJ, Chen Y, Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle. Circulation, 2008 Oct 21;118(17):1713-212008
Hu X, Xu X, Huang Y, Fassett J, Flagg TP, Zhang Y, Nichols CG, Bache RJ, Chen Y, Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Circulation research, 2008 Oct 24;103(9):1009-172008
Xu X, Fassett J, Hu X, Zhu G, Lu Z, Li Y, Schnermann J, Bache RJ, Chen Y, Ecto-5'-nucleotidase deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction. Hypertension (Dallas, Tex. : 1979), 2008 Jun;51(6):1557-642008
van Deel ED, Lu Z, Xu X, Zhu G, Hu X, Oury TD, Bache RJ, Duncker DJ, Chen Y, Extracellular superoxide dismutase protects the heart against oxidative stress and hypertrophy after myocardial infarction. Free radical biology & medicine, 2008 Apr 1;44(7):1305-132008
Lu Z, Xu X, Hu X, Zhu G, Zhang P, van Deel ED, French JP, Fassett JT, Oury TD, Bache RJ, Chen Y, Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension (Dallas, Tex. : 1979), 2008 Jan;51(1):19-252008
Traverse JH, Chen Y, Hou M, Li Y, Bache RJ, Effect of K+ATP channel and adenosine receptor blockade during rest and exercise in congestive heart failure. Circulation research, 2007 Jun 8;100(11):1643-92007
Dickey DM, Flora DR, Bryan PM, Xu X, Chen Y, Potter LR, Differential regulation of membrane guanylyl cyclases in congestive heart failure: natriuretic peptide receptor (NPR)-B, Not NPR-A, is the predominant natriuretic peptide receptor in the failing heart. Endocrinology, 2007 Jul;148(7):3518-222007
Zhang P, Xu X, Hu X, van Deel ED, Zhu G, Chen Y, Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circulation research, 2007 Apr 13;100(7):1089-982007
Bryan PM, Xu X, Dickey DM, Chen Y, Potter LR, Renal hyporesponsiveness to atrial natriuretic peptide in congestive heart failure results from reduced atrial natriuretic peptide receptor concentrations. American journal of physiology. Renal physiology, 2007 May;292(5):F1636-442007
Hou M, Hu Q, Chen Y, Zhao L, Zhang J, Bache RJ, Acute effects of febuxostat, a nonpurine selective inhibitor of xanthine oxidase, in pacing induced heart failure. Journal of cardiovascular pharmacology, 2006 Nov;48(5):255-632006
Huang X, Pan W, Grindle S, Han X, Chen Y, Park SJ, Miller LW, Hall J, A comparative study of discriminating human heart failure etiology using gene expression profiles. BMC bioinformatics, 2005 Aug 24;6:2052005
Chen Y, Li Y, Zhang P, Traverse JH, Hou M, Xu X, Kimoto M, Bache RJ, Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts. American journal of physiology. Heart and circulatory physiology, 2005 Nov;289(5):H2212-92005
Huang X, Pan W, Han X, Chen Y, Miller LW, Hall J, Borrowing information from relevant microarray studies for sample classification using weighted partial least squares. Computational biology and chemistry, 2005 Jun;29(3):204-112005
Chen Y, Hou M, Li Y, Traverse JH, Zhang P, Salvemini D, Fukai T, Bache RJ, Increased superoxide production causes coronary endothelial dysfunction and depressed oxygen consumption in the failing heart. American journal of physiology. Heart and circulatory physiology, 2005 Jan;288(1):H133-412005
Kittleson MM, Ye SQ, Irizarry RA, Minhas KM, Edness G, Conte JV, Parmigiani G, Miller LW, Chen Y, Hall JL, Garcia JG, Hare JM, Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy. Circulation, 2004 Nov 30;110(22):3444-512004
Hou M, Chen Y, Traverse JH, Li Y, Barsoum M, Bache RJ, ET-A receptor activity restrains coronary blood flow in the failing heart. Journal of cardiovascular pharmacology, 2004 Jun;43(6):764-92004
Hall JL, Grindle S, Han X, Fermin D, Park S, Chen Y, Bache RJ, Mariash A, Guan Z, Ormaza S, Thompson J, Graziano J, de Sam Lazaro SE, Pan S, Simari RD, Miller LW, Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks. Physiological genomics, 2004 May 19;17(3):283-912004
Huang X, Pan W, Park S, Han X, Miller LW, Hall J, Modeling the relationship between LVAD support time and gene expression changes in the human heart by penalized partial least squares. Bioinformatics (Oxford, England), 2004 Apr 12;20(6):888-942004
Chen Y, Park S, Li Y, Missov E, Hou M, Han X, Hall JL, Miller LW, Bache RJ, Alterations of gene expression in failing myocardium following left ventricular assist device support. Physiological genomics, 2003 Aug 15;14(3):251-602003
Chen Y, Traverse JH, Hou M, Li Y, Du R, Bache RJ, Effect of PDE5 inhibition on coronary hemodynamics in pacing-induced heart failure. American journal of physiology. Heart and circulatory physiology, 2003 May;284(5):H1513-202003
Chen Y, Traverse JH, Du R, Hou M, Bache RJ, Nitric oxide modulates myocardial oxygen consumption in the failing heart. Circulation, 2002 Jul 9;106(2):273-92002
Traverse JH, Chen Y, Hou M, Bache RJ, Inhibition of NO production increases myocardial blood flow and oxygen consumption in congestive heart failure. American journal of physiology. Heart and circulatory physiology, 2002 Jun;282(6):H2278-832002
Traverse JH, Chen Y, Crampton M, Voss S, Bache RJ, Increased extravascular forces limit endothelium-dependent and -independent coronary vasodilation in congestive heart failure. Cardiovascular research, 2001 Dec;52(3):454-612001
Chen Y, Traverse JH, Zhang J, Bache RJ, Selective blockade of mitochondrial K(ATP) channels does not impair myocardial oxygen consumption. American journal of physiology. Heart and circulatory physiology, 2001 Aug;281(2):H738-442001
Chen Y, Du R, Traverse JH, Bache RJ, Effect of sildenafil on coronary active and reactive hyperemia. American journal of physiology. Heart and circulatory physiology, 2000 Nov;279(5):H2319-252000
Traverse JH, Chen YJ, Du R, Bache RJ, Cyclic nucleotide phosphodiesterase type 5 activity limits blood flow to hypoperfused myocardium during exercise. Circulation, 2000 Dec 12;102(24):2997-30022000
Chen YJ, Serfass RC, Apple FS, Loss of myocardial CK-MB into the circulation following 3.5 hours of swimming in a rat model. International journal of sports medicine, 2000 Nov;21(8):561-52000
Chen Y, Serfass RC, Mackey-Bojack SM, Kelly KL, Titus JL, Apple FS, Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise. Journal of applied physiology (Bethesda, Md. : 1985), 2000 May;88(5):1749-552000
Chen Y, Serfass RC, Apple FS, Alterations in the expression and activity of creatine kinase-M and mitochondrial creatine kinase subunits in skeletal muscle following prolonged intense exercise in rats. European journal of applied physiology, 2000 Jan;81(1-2):114-92000
Huang YM, Chen YJ, Zhong W, Guo QF. The effects of strenuous exercise on blood viscosity and deformational ability of erythrocytes in rats J Chinese Sports Med 1996;15:230-2331996
Chen YJ, Guo QF. Free radical injury in exercise induced delayed onset muscle damage Chinese J Sports Med 1993;12:130-138.1993
Chen YJ, Guo QF. Calcium overload in exercise induced delayed onset muscle damage Chinese J Sports Med 1992;11:133-141.1992
Chen YJ, Guo QF, Zhao BL, Xin WJ. Electron spinal resonance studies on free radical metabolism of rats different fiber types during muscle fatigue. Chinese J Sports Med 1991;10:135-139. (The 1st author).1991
Yingjie Chen Calcium in exercise J National Res Inst Sports Sci 1990;3:66-69.
Liu X, Zheng L, Zhou Y, Chen Y, Chen P, Xiao W, BMSC Transplantation Aggravates Inflammation, Oxidative Stress, and Fibrosis and Impairs Skeletal Muscle Regeneration. Frontiers in physiology, 2019;10:87
Fassett JT, Xu X, Kwak D, Wang H, Liu X, Hu X, Bache RJ, Chen Y, Microtubule Actin Cross-linking Factor 1 regulates cardiomyocyte microtubule distribution and adaptation to hemodynamic overload. PloS one, 2013;8(9):e73887
Zhang P, Xu X, Hu X, Wang H, Fassett J, Huo Y, Chen Y, Bache RJ, DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis. PloS one, 2013;8(11):e79444
Lu YY, Li ZZ, Jiang DS, Wang L, Zhang Y, Chen K, Zhang XF, Liu Y, Fan GC, Chen Y, Yang Q, Zhou Y, Zhang XD, Liu DP, Li H, TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death. Nature communications, 2013;4:2852
Liu X, Fassett J, Wei Y, Chen Y, Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases. Evidence-based complementary and alternative medicine : eCAM, 2013;2013:619207

Book Chapter

Chen Y, Traverse J, Bache RJ Effect of PDE-5 inhibition on coronary blood flow in experimental animals. Page 163-177; Heart Disease and Erectile Dysfunction. Edt RA. Kloner. 2004 Human Press Inc. New Jersey.2004
Chen YJ, Quo AF. Free radical injury in exercise induced delayed onset muscle damage--a primary study of mechanism of delayed onset muscle damage Sports, Medicine and Health. The Asian Perspective. Ed. K. M. Chan 1992, 135-140, Hong Kong. (The 1st author).1992

Comment

Weir EK, Hong Z, Chen Y, Superoxide dismutase: master and commander? The European respiratory journal, 2010 Aug;36(2):234-62010
Chen Y, Bache RJ, Adenosine: a modulator of the cardiac response to stress. Circulation research, 2003 Oct 17;93(8):691-32003

Editorial

Bache RJ, Chen Y, NOX2-induced myocardial fibrosis and diastolic dysfunction: role of the endothelium. Journal of the American College of Cardiology, 2014 Jun 24;63(24):2742-42014

Presentations

National and International Invited Seminars/Lectures, Overexpression of Alanine-Glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function, AHA Scientific Sessions11/2019
National and International Invited Seminars/Lectures, Effect of air pollution and lung remodeling on the transition from left heart failure to right heart failure, The 30th GW-OCC, Beijing10/2019
National and International Invited Seminars/Lectures, Effect of PM2.5 on the transition from left heart failure to right heart failure, The 13th OCC, Shanghai06/2019
National and International Invited Seminars/Lectures, Cardiovascular risk factor ADMA in regulating heart failure development, The 13th OCC06/2019
Regional Invited Seminars/Lectures, Role of Tregs in attenuating the transition from left heart failure to right heart failure, University of Minnesota, Minneapolis05/2019
National and International Invited Seminars/Lectures, Short term PM2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy, 2019 EB Meeting, Orlando04/2019
National and International Invited Seminars/Lectures, Effect of T cells on heart failure development and progression, EB Meeting, Orlando04/2019
National and International Invited Seminars/Lectures, Effect of T cell activation on heart failure progression, The 29thth GW-OCC, Beijing10/2018
National and International Invited Seminars/Lectures, Effect of lung remodeling on the transition from left heart failure to right heart failure, The 12th Oriental Congress of Cardiology, Shanghai06/2018
National and International Invited Seminars/Lectures, Harnessing the T cell function as a new direction in attenuating the transition from left heart failure to right heart failure, The 12th Oriental Congress of Cardiology, Shanghai05/2018
Poster Presentation, Effect of CD44 on the transition from left heart failure to right heart failure, University of Minnesota04/2018
National and International Invited Seminars/Lectures, Harnessing the T cell function as a new direction in attenuating the transition from left heart failure to right heart failure, Keystone Heart Failure: Crossing the Translational Divide, Keystone, Keystone01/2018
National and International Invited Seminars/Lectures, Inhibition of eukaryotic translation initiation factor 4E-3 (eif4E3) protects the heart against heart failure development, 11th Eleventh Oriental Congress of Cardiology, Shanghai06/2017
National and International Invited Seminars/Lectures, Role of bone marrow-derived dendritic cells in pressure overload-induced cardiac inflammation and hypertrophy, 11th Eleventh Oriental Congress of Cardiology, Shanghai06/2017
National and International Invited Seminars/Lectures, Transgenic Overexpression of Alanine-glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function, AHA ATVB, Minneapolis05/2017
National and International Invited Seminars/Lectures, Cd44 Plays an Important Role in Regulating Heart Failure Induced Lung Vascular Remodeling and Who Type-2 Pulmonary Hypertension, AHA Arteriosclerosis, Thrombosis and Vascular Biology/Peripheral Vascular Disease 2017 Scientific Sessions05/2017
National and International Invited Seminars/Lectures, Transgenic Overexpression of Alanine-glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function, 2016 AHA Scientific Sessions, New Orleans, Louisiana, USA11/2016
National and International Invited Seminars/Lectures, The important role of lung remodeling in heart failure progression, The 20th GW-OCC, Beijing10/2016
National and International Invited Seminars/Lectures, End-stage Heart Failure Causes Severe Lung Fibrosis and Dysfunction, Basic Cardiovascular Sciences 2016 Scientific Sessions, Phoenix07/2016

Honors, Awards, and Recognition

Fellow of American Physiology Society, American Physiology Society2015
Excellent service award, Academy of Cardiovascular Research Excellence2012
Dr. Marvin and Hadassah Bacaner Research Award, University of Minnesota2008
Lillehei Scholar, School of Medicine, University of Minnesota2005
Dean's Faculty Recruit, School of Medicine, University of Minnesota2005
Scientist Development Award, American Heart Association2003
Distinguished Contribution Award, Chinese Olympic Comittee1992
Honorable mention of Sports Science Award, President of International Olympic Committee1992

Professional Membership and Service

Free Radical Biology Society, Member2019 - Present
American Physiology Society, Fellow2015 - Present
American Heart Association, Professional Membership2012 - Present
Academy of Cardiovascular Research Excellence, Fellow2003 - Present

Committee Service

Department of physiology graduate admissions committee, Member2020 - Present
Medical Student Research Committee, Member2020 - Present
Research mentoring committee, Member2018 - 2019
American Heart Association Center Grant Review Committee, Member2017 - Present
American Heart Association Basic Sciences Peer Review Committee, Member2014 - 2019
Academy of Cardiovascular Research Excellence, General Secretary2012 - 2016
ACRE-cnAHA Cardiovascular Research Symposium, Organizing committee member or co-chair2011 - 2018
International Academy of Cardiology, Scientific advisory board2010 - 2019
International Academy of Cardiology, Member2010 - 2019
LHI Cardio Ploozo, Member2010 - 2019
LHI Summer Undergraduate Research Experience, Member2010 - 2019
Department of Medicine Research Day, Judge2007 - 2019

Community Service

American Heart Association, Grant reviewer05/2014 - 06/2019
INTERNATIONAL ACADEMY OF CARDIOLOGY, abstract grading03/2012 - 07/2018
The 16th International Academy of cardiology, abstract grading03/2011 - 05/2011
International Society for Free Radical Research, Grading abstracts05/2010 - Present
Abstract grading for 15th International Academy of cardiology, Abstract grading03/2010 - 04/2010
Grant review fro NIH, Grant Reviewer06/2006 - 10/2018

Other Service

2015 NIH SBIR/STTR grant review panel2018 - Present
2018 Summer's Wish Pediatric Cardiology Innovators Fund, 2018 Summer's Wish Pediatric Cardiology Innovators Fund, University of Minnesota2018 - Present
American Heart Association, MOLECULAR SIGNALING & CELL TRANS 22018 - 06/2019
NIH ZRG1 Grant peer review study section committee member, NIH ZRG1 Vascular and Hematology AREA Application Review Panel (VH) R152018 - Present
2017 AHA Center grant review2017 - Present
2017 NIH SBIR/STTR grant review pane2017 - Present
Grant peer review committee member, NIH06/2015 - Present
NIH CCHF study section06/2014 - Present
American Heart Association, Cell Signaling 3&4, American Heart Association, Cell Signaling 3&42014 - 12/2017
2018 NIH SBIR/STTR grant review2008 - Present
Grant reviewer, Reviewer for Research Grant Management Group2005 - 12/2007
Reviewer for 46 journals, Reviewer for 46 journals: Antioxidants and Redox Signal; Arteriosclerosis, Thrombosis, and Vascular Biology; Atherosclerosis; American Journal of Physiology; Acta Pharmaceutica Sinica; Cardiovascular Therapy; Circulation; Circulation Research; Circulation---Heart Failure; Diabetes; European Journal of Heart Failure; Eur Respir J; Experimental Biology and Medicine; Evidence-Based Complementary and Alternative Medicine; Frontier Oncology; Frontier Physiology; Free Radical Biology and Medicine Heart Failure; Hypertension; Human Gene Therapies; Journal of the American College Cardiology; Journal of Clinical Investigation; JCI Insights; International Journal of Molecular Sciences; Journal of Physiology and Pharmacology; Journal of Cardiac Failure; Journal of Cardiovascular Translational Research; Journal of Molecular and Cellular Cardiology; Lab Investigation; JOVE; Molecular and Cellular Biochemistry (MCBI); Nature Protocols; Nature Communications; Naunyn-Schmiedeberg's Archives of Pharmacology; Nitric Oxide; Nutrition & Metabolism; Nutrition, Metabolism & Cardiovascular Diseases; Oxidative Medicine and Cellular Longevity; Proceedings of the National Academy of Sciences; PLoS ONE; Redox of Biology; Sport Science; The Journal of Experimental Medicine; Tongji Xuebao; Translational Research; Trends in Cardiovascular Medicine.07/2001 - 08/2020
Nature Communications
Nature Protocols
Journal of Clinical Investigation
Hypertension
Diabetes
Circulation Research
Circulation
Kentucky Medical Foundation, Grant reviewer for Kentucky Medical Foundation grant reviewer from 2005 to 2007
NIH NHLBI, Study Section of Exploratory Program in Systems Biology, NIH NHLBI, Study Section of Exploratory Program in Systems Biology
Grant reviewer for NIH NHLBI, 2008 NHLBI, Exploratory Program in Systems Biology
Reviewer for Minnesota Medical Foundation, 2018 academic year
Grant peer review study section committee member, 2012, Indiana Medical Foundation grant reviewer

Teaching Experience

Medicine, Lecture, Lecturer, The Effect of T Cell Activation & Lung Inflammation on Heart Failure Development and ProgressionAnnual 2020 - 2020
Medicine, Lecture, Lecturer, The role of T Cell Activation in Heart Failure ProgressionAnnual 2020 - 2020
Lecture, Lecturer, The Effect of T Cell Activation & Lung Inflammation on Heart Failure Development and ProgressionAnnual 2020 - 2020
Medicine, Small Group, Lecturer, The Important Role of CD44 in Heart Failure DevelopmentFall 2019
Medicine, Lecture, Lecturer, Effect of Inflammation on the transition from left heart failure to right heart failureFall 2018 - 2018

Directed Student Learning

Doctoral Advisory Committee Chair, Isolevuglandin effects on lung remodeling and the transition from left heart failure to right heart failure
Advised: Lin Shang
2017 - 2020
Doctoral Advisory Committee Chair, Effect of T cells on heart failure development
Advised: Dongzhi Wang
2016 - 2019
Internship Advisor, NA
Advised: Liuqing Yang
2015 - 2016
Research Advisor, Effect of 4E3 on heart failure development
Advised: Hailing Li
2013 - 2014
Research Advisor, NA
Advised: Shuo Yan
2012 - 2013
Doctoral Advisory Committee Chair, DDAH1 effects on pulmonary hypertension development
Advised: Dongmin Kwak
2010 - 2016
Research Advisor, Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase
Advised: Dachun Xu
2009 - 2011
Research Advisor, Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3
Advised: Haipeng Guo
2009 - 2011
Doctoral Advisory Committee Member, Coronary blood flow regulation during heart failure development
Advised: Xin Xu
2003 - 2005

Fellows supervised

Cardiovascular research, Post-Doc Advisor, 0 fellows supervised07/2006 - 06/2015
Cardiovascular research, Post-Doc Advisor, 18 fellows supervised05/2003 - 08/2019

Residency Training

Cardiovascular Division, Research Advisor
Cardiovascular Division, Research Advisor
Cardiovascular research, Research Advisor