Jian-xiong Chen, MD, FAHA

Jian-xiong Chen, MD, FAHA

Professor

Department:
SOM-Pharmacology/Toxicology

Email:
jchen3@umc.edu

Work Phone:
(601) 984-1731

Biography

I am a tenure professor in the department of Pharmacology and Toxicology. I received the M.D. and a master’s degree in pharmacology from Central South University of China. I completed the join PhD program at Southern Illinois University school of Medicine and Central south university. I then continued postdoctoral training in pathology at Vanderbilt University Medical Center. I served as an assistant professor in Pathology, and became associate professor of Pediatrics at Vanderbilt University from 2002-2010. I joined the University of Mississippi Medical Center as an associate professor at Department of Pharmacology and Toxicology in 2011. I am Fellow of American Heart Association (AHA) and member of American Physiology Society. I have served as a grant reviewer committee of NIH, AHA and British Medical Research Council. I have been a part of a very successful research team that have been well-funded by NIH and AHA. My current research interesting is focus to understanding the intracellular molecular mechanisms that regulate coronary microvascular dysfunction, heart failure with preserved ejection fraction (HFpEF) and diabetic cardiomyopathy, then, to develop novel gene therapies for the treatment devastating heart failure. I am the author of 83 peer-reviewed publications and currently funded by National Heart, Lung and Blood Institute. I serves as Editor of Journal of cardiovascular pharmcology.

Education

Vanderbilt University Medical Center, Postdoctoral Fellow, pathology2001
Henan Medical University, MS, pharmacology1990
Hunan Medical University, MD, Medicine1985

Current Positions

Professor, School of Medicine07/2018 - Present
The University of Mississippi Medical Center
Jackson, Mississippi 39216

Academic Appointments or Other Previous Appointments

Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology2011 - 07/2018
Associate Professor, vanderbilt, School of Medicine, Department of Pediatrics2010 - 2011
Assistant Professor, vanderbilt, School of Medicine, Department of Pathology2002 - 2010
Department Chair, Hengyang Medical College, School of Medicine1992 - 03/1996
Associate Professor, Hengyang Medical College, School of Medicine1992 - 03/1996
Assistant Professor, Hengyang Medical college, School of Medicine07/1985 - 07/1987

Sponsored Program Funding

Extramural, P53 acetylation in microvascular rarefaction and heart failure, NHLBI12/2024 - 11/2028
Extramural, Inactivation of Sirt3-mediated ferroptosis in the heart of Friedreich’s ataxia, NHLBI12/2024 - 11/2028
Extramural, Notch3 in coronary microvascular dysfunction and diastolic dysfunction of diabetes, NHLBI12/2024 - 11/2028
Extramural, p53 acetylation in microvascular rarefaction and heart failure, NHLBI09/2022 - 08/2023
Extramural, Endothelial PHD2 in hypertensive vascular remodeling, NHLBI/NIGMS09/2021 - 06/2025
Extramural, Altered Coronary Endothelial-Pericyte Interactions in Diabetes, NHLBI10/2020 - 09/2024
Intramural, Altered Coronary Endothelial-Pericyte Interactions in Diabetes, UMMC10/2019 - 09/2020
Extramural, Coronary microvascular rarefaction in diabetic/obese heart, NHLBI03/2017 - 02/2021
Intramural, coronary microvascular rarefaction in diabetic/obese heart, UMMC10/2016 - 09/2017
Extramural, Regulation of vascular maturation/regression in diabetes, NIH/NHLBI07/2010 - 03/2016
Extramural, Functional Role of Angiopoietin-2 in Diabetic Heart, NIH/NIDDK04/2006 - 03/2010
Extramural, Angiopoietins/Tie-2 and Diabetic Impaired Myocardial Angiogenesis, American Heart Association07/2005 - 06/2007
Extramural, Hsp90/Client Protein Interactions in the Newborn Lung, NIH/NHLBI04/2005 - 03/2009
Extramural, Effects of Hypoxia on the Coronary Microcirculation, NIH/NHLBI06/2000 - 05/2005

Publications

Journal Article

Chen JX, Wu HX, Wang Y The role of endotoxin in the bronchial hyperreactivity formation Chinese Medical Journal. 1994; 74(1):38-9, 64
Chen JX, Cao YS Protection ammonium glycyrrhizanate against endotoxin-induced bronchial hyperreactivity. Chinese Journal of Pharmacology and Toxicology, 1994, 8(3):235-236.
Chen JX, Cao YS. Effect ammonium glycyrrhizanate against endotoxin-induced bronchial hyperreactivity-in relation to beta-cAMP system. Chinese Traditional and Herbal Drugs, 1994, 1(1):17-18.
Chen JX, Tang XQ, Zhu BY, Liao DF. The mechanism of exogenous oxygen free radicals induced vasospasm of isolated basilar artery. Chinese Journal Arteriosclerosis, 1994, 2(2):88-91.
Chen JX, Liao DF, Yu L, Xiao GL, Zhu BY, Tang XQ. Protective effect of captopril on electrolyzed perfusion solution induced vasospasm of isolated basilar artery. Chinese Journal of Pharmacology and Toxicology, 1995, 9(1):44-46.
Chen JX, Liao DF, Tang XQ, Yu L, Zeng H, Cao JG. Protection of Gypenosides against oxygen free radical induced vasospasm of isolated rabbit basilar artery. Chinese Traditional and Herbal Drugs, 1997, 28(4):219-221.
Liao DF, Chen JX, Huang HL, Tang XQ, Cao JG and Yu L. Correlation between the protection of probucol on injury of endothelial cells by free radicals and the activity of nitric oxide Chinese Journal Arteriosclerosis, 1994, 2(2):67-71.
Wan Y, Weng SA, Chen JX, Wu HX, Cao YS. Effects of estradiol on asthma of guinea pigs and its relationship to beta-adrenergic receptors. Chinese Pharmacological Bulletin, 1993, 9(4):295-297.
Xiao GL, Liao DF, Chen JX, Yu L. Protective effect of gypenosides on OFR-induced damage of relaxing capacity of rabbit thoracic aortae in vitro. Chinese Pharmacological Bulletin, 1994, 10(2):136-138.
Li LX, Yu L, Chen JX, Liao DF, Cao JG, Chen LX, Huang HL and Zhu BY. Oxidized low density lipoprotein promotion of adhesion of monocytes to endothelial cells in vitro. Chinese Journal Arteriosclerosis, 1996, 4(4):272-275.

Book Chapter

Chen JX, Zeng H, Chen X, Su CY, Lai CC. Heme oxygenase, Ginkgo biloba extract and its terpenoids protect myocytes against oxidative injury. In: Heme Oxygenase in Biology and Medicine. NG Abraham, ed., 2002, pp. 399-408.

Presentations

Poster Presentation, Deficiency Of Sirtuin 3 In Endothelium Reduces Endothelial-Dependent Relaxation And Impairs Myogenic Response In Coronary And Middle Cerebral Arteries Of Mice, AHA11/2023
Poster Presentation, Endothelial Phd2 Deficiency Promotes Angiotensin-Ii-Induced Arterial Stiffness And Coronary Microvascular Dysfunction, North American Vascular Biology10/2023
Poster Presentation, Treatment with PFKFB3 inhibitor potentially improves diastolic function and arterial stiffness in PHD2ECKO mice, APS summit04/2023
Poster Presentation, Potential role of Ferrostatin-1 as a mitochondrial-targeting agent for the treatment of mitochondrial cardiomyopathy, APS summit04/2023
Poster Presentation, Ferrostatin-1 Ameliorates Cardiac Dysfunction in a Cardiomyocyte-Specific SIRTUIN 3 Knockout Mouse Model
(Excellent Post Award), Hypertension, AHA
09/2022
Poster Presentation, Regulatory Role Of Endothelial Phd2 On Hypertensive Arterial Stiffness And Vascular Calcification, Vascular Discovery, AHA05/2022
Poster Presentation, Novel Regulatory Role of SIRT3 on Cardiomyocyte Mitochondrial Frataxin and Ferroptosis, EB meeting05/2022
Platform Presentations, Deficiency of Sirtuin 3 disrupts endothelial glucose metabolism and sensitizes pressure-overload induced heart failure11/2019
Poster Presentation, Deficiency of sirtuin 3 accentuates angiotensin II-induced arterail stiffness/myocardial fibrosis and hypertension, EB Meeting04/2019
Poster Presentation, regulatory role of endothelial sirt3 on blood pressure and diastolic dysfunction in a female mice., Hypertension, AHAH09/2018
Poster Presentation, ablation of endothelial sirt3 exacerbates pressure overload-induced heart failure, BCVS, AHA08/2018
Poster Presentation, Sirtuin 3 attenuates diabetic cardiomyopathy via suppression of p53 acetylation and regulating cardiomyocyte metabolism, Experimental Biology, San Diego04/2018
Poster Presentation, Deletion of endothelial Sirt3 causes diastolic dysfunction, AHA council on hypertension, San Francisco, CA09/2017
Poster Presentation, Treatment with Prolyl Hydroxylase Inhibitor Reverses Pre-Existing Diastolic Dysfunction in the Aged SIRT3 Knockout Mice, 2017 Experimental Biology in Chicago, Chicago, IL04/2017
State/Local Invited Seminars/Lectures, New perspective of Angiopoietins/Tie-2 system in Sepsis, Fushan Hospital, Guang Dong, P.R. China05/2016
State/Local Invited Seminars/Lectures, Emerging role of Sirtuin 3 in EC metabolism and diastolic dysfunction, Human University of Chinese Medicine, P.R. China05/2016
Poster Presentation, Deletion of Endothelial Sirt3 Causes Coronary Microvascular Dysfunction and HFpEF., Experimental Biology, San Diego, CA04/2016
Regional Invited Seminars/Lectures, Emerging role of Sirtuin 3 in EC metabolism and angiogenesis”., University of Southern Illinois, School of Medicine, Department of Microbiology and Biochemistry, Springfield, IL09/2015
National and International Invited Seminars/Lectures, New perspective of Angiopoietins/Tie-2 system in Sepsis, Human University of Chinese Medicine, P.R. China., Changsha05/2015
National and International Invited Seminars/Lectures, Mechanisms of impairment of myocardial angiogenesis in type II diabetes, University of Beijing Medical Center, Department of Physiology and Physiopathology., Beijing09/2014
National and International Invited Seminars/Lectures, New perspective of Angiopoietins/Tie-2 system in Sepsis, Summit of international critical care 2014, Beijing09/2014
Platform Presentations, SIRT3 Deficiency Impairs Hypoxic Signaling, Reprograms Basal Glycolytic Metabolism and Exacerbates Myocardial Ischemic Injury., Experimental Biology, Boston, MA03/2014
Platform Presentations, Sirt3 is essential for apelin-gene therapy mediated cardiac repair in post-myocardial infarction of diabetes., High blood pressure Research Scientific sessions, New orleans09/2013
Poster Presentation, Sirt3 regulates oxygen sensors and blood vessel formation in the heart., High Blood Pressure Research (HBPR), New Orleans, LA09/2013
State/Local Invited Seminars/Lectures, Mechanisms of impairment of myocardial angiogenesis in type II diabetes, University of Mississippi Medical Center, Department of Biochemical Science, Jackson, MS.12/2012
Poster Presentation, Apelin-13 Increases Myocardial Progenitor Cells and Improves Myocardial Remodeling of Post-myocardial, Hypertension council meeting, New orlean09/2012
Poster Presentation, Regulation Of Sirt3 And Autophagy By Bone Marrow Cells Therapy Improves Cardiac Repair In Post-myocardial Infarction Mice., AHA meeting, Dallas07/2012
Poster Presentation, Apelin Reduces Myocardial Infarction Size and Promotes Angiogenesis by Increasing SDF-1/CXCR4 and AKT/eNOS/VEGF pathways, AHA meeting, Dallas07/2012
Poster Presentation, Ang-1 reduces myocardial infarction via upregulation of SDF-1/CXCR4 and recruiting hematopoietic progenitor cells in the diabetic db/db mouse model., AHA, Orlando, FL11/2011
Regional Invited Seminars/Lectures, Angiopoietins/Tie-2 system in diabetic complications, University of Southern Mississippi, Department of Biological Science, Hattiesburg, MS11/2011
Poster Presentation, Overexpression of angiopoietin-2 promotes myocardial fibrosis and rarefaction in diabetic db/db mouse model., EB meeting, Washington, DC04/2011
State/Local Invited Seminars/Lectures, Angiopoietins/Tie-2 in diabetic infarcted heart, University of Mississippi Health Center, Department of Physiology& Biophysics, Jackson, MS.03/2011
Regional Invited Seminars/Lectures, Angiopoietins/Tie-2 system in diabetic vascular complications, Department of Pharmacology, University of Mississippi medical Center, Jackson, MS07/2010
Regional Invited Seminars/Lectures, Angiopoietins/Tie-2 system and diabetic abnormal angiogenesis, Department of Pharmacology and Physiology, University of Missouri, Columbia, MO05/2010
State/Local Invited Seminars/Lectures, NADPH oxidase and diabetic angiogenesis, Beijing University Medical Center, Beijing, PR China07/2008
Regional Invited Seminars/Lectures, Angiopoietins/Tie-2 in diabetic complications, University of South China, Hengyang, Hunan, PR. China.07/2008
Poster Presentation, Inhibition of protein tyrosine phosphatase improves hyperglycemic impaired angiogenesis., CIRCULATION, 16: 25-25; 2007 (Poster)11/2007
Platform Presentations, Leptin stimulates angiogenesis in myocardial endothelial cells: Involvement of p47phox NADPH oxidase., Experimental Biology meeting, FASEB JOURNAL 21: A180-A180; 2007.04/2007
Platform Presentations, High glucose blunts angiopoietin-1 (Ang-1)-induced angiogenesis in myocardial endothelial cells via impairment of Akt and eNOS phosphorylation., FASEB JOURNAL 21: A130-A131; 2007.04/2007
Platform Presentations, Hypoxia/reoxygenation-induced myocardial angiogenesis: Role of NADPH oxidase derived reactive oxygen species (ROS), AHA meeting, CIRCULATION 114: 155-155; 2006.11/2006
State/Local Invited Seminars/Lectures, Angiogenesis and cardiovascular diseases, University of South China, Hengyang, Hunan, PR. China.06/2006
Platform Presentations, Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis, Experimental biology meeting, FASEB JOURNAL 18: A385-A385; 2004.03/2004
Platform Presentations, Hypoxia increases heat shock protein 90 binding (Hsp90) to endothelial nitric oxide synthase (eNOS) via a P13-Akt pathway in porcine coronary artery endothelium (PCAEC) ., Experimental Biology Meeting; San Diego, FASEB JOURNAL 17: A805-A805; 200304/2003

Honors, Awards, and Recognition

Excellence in Research Award,Golden Level., The University of Mississippi Medical Center2013
Excellence in Research Award, Silver Level., The University of Mississippi Medical Center2012
Excellence in Research Award,Bronze Level., The University of Mississippi Medical Center2011
Achievement Award in Science and Technology, Ministry of Science and Technology of Hunan Province, P. R. China1999
Achievement Award in Cardiovascular Research, Bureau of Medicine and Hygiene of Hunan Province, P. R. China1999
Recipient of Excellent Award in Teaching, Education Commissioner of P.R. China1994
Recipient of Excellent Award in Teaching, Education Commissioner of Hunan province, P.R. China1992

Professional Membership and Service

North American Vascular Biology Organization, Member2023 - Present
American Heart Association, Member2001 - Present
American Physiological Society, Member2001 - Present

Committee Service

P&T committee, Member2018 - Present
Research day, Member2016 - 2016
Strategic planning/COBRE/PPG committee, Member2016 - Present
Professional Education committee, Member2013 - Present
Graduate Program Committee, Member2012 - Present
Department Faculty recruitment committee, Member2012 - Present

Other Service

Editor05/2024 - Present
Pilot grant09/2023 - 09/2023
Nature Reviews Cardiology06/2023 - 06/2023
CARDIOVASCULAR DIFFERENTIATION AND DEVELOPMENT STUDY SECTION, NIH02/2023 - 02/2023
Ad Hoc reviewer for Special Emphasis Panel/Scientific Review Group ZRG1 F10C-C05/2022 - 05/2022
Ad hoc reviewer for NIH Special Emphasis Panel (SEP), ZRG1 CVRS B_02.07/2021 - 07/2021
Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review07/2020 - 07/2020
cardiac group grant review07/2020 - Present
Pilor grant09/2019 - 09/2019
Chair of EB meeting section: Diabetes: A metabolic Karma04/2019 - 04/2019
Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review06/2018 - 06/2018
Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review10/2017 - 10/2017
Ad hoc reviewer for NIH Special Emphasis Panel/PPG Review, member06/2015 - 06/2015
Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member05/2015 - 05/2015
Journal of cardiovascular pharmacology2015 - Present
Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member02/2014 - 02/2014
Journal of Contemporary Diabetes Research2014 - Present
Diabetes Research-open Journal2014 - 12/2017
Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member10/2013 - 11/2013
Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member05/2013 - 05/2013
Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member01/2013 - 01/2013
Cardiovascular Genetics and Systems Medicine2013 - Present
Ad hoc reviewer for NIH-Cell, Molecular, and Computational Biology, member11/2012 - 11/2012
Ad hoc reviewer for Medical Research Council (United Kingdom), member05/2012 - 05/2012
Regular Reviewer for Vascular Wall Biology Committee of American Heart Association (Vas Wall Bio AAGI BSc2), member05/2011 - 10/2013
Reviewer: Journal of cardiovascular pharmacology, JAHA, Cell Physiol Biochem, oncotarget, Acta Pharmacological Sin; Acta Biochim Biophys Sin; American Journal of Pathology; European Journal of Pharmacology; Journal of Thrombosis and Heamostasis; Canadian Journal of Physiology and Pharmacology, Clinical and Experimental Pharmacology and Physiology; Journal of Pediatric Endocrinology and Metabolism; Arterioscler Thromb Vasc Biol; PLoS ONE; Diabetes; Biochemical and Biophysical Research Communications, experimental cell research2011 - Present

Teaching Experience

Dentistry, Lecture, Lecturer, Dental PharmacologyAnnual 2018-2024 - 2024
1, Medicine, Lecture, Lecturer, Medical PharmacologyAnnual 2018-2024
1, Graduate, Lecture, Lecturer, the mechanisms of drug actionAnnual 2018-2024
1, Graduate, Lecture, Lecturer, Pharmacology mechanismsAnnual 2018-2024
1, Dentistry, Small Group, Course Presenter, Review SessionAnnual 2018-2024
1, Medicine, Small Group, Course Presenter, Medical pharmacology Review SessionAnnual 2018-2024
1, Dentistry, Course, Course Director, dental pharmacologyAnnual 2017-2024
Dentistry, Lecture, Lecturer, anti-histamine drugsSpring 2017
Dentistry, Lecture, Lecturer, Asthma therapeuticSpring 2017
Dentistry, Course, Course Director, Dental pharmacologySpring 2017
Graduate, Lecture, Lecturer, Approaches to study Control of AngiogenesisSpring 2017
4, Medicine, Small Group, Facilitator, autonomic drug responsesFall 2017 - 2017
1, Medicine, Lecture, Lecturer, Histamine and H1 receptor antagonistsFall 2017 - 2017
1, Medicine, Lecture, Lecturer, Drug used in the treatment of asthmaFall 2017 - 2017
4, Medicine, Small Group, Facilitator, cardiovascular case studyFall 2017
2, Graduate, Lecture, Lecturer, angiogenesis & vessel rarefication IIFall 2017 - 2017
Dentistry, Lecture, Lecturer, Asthma therapeuticSpring 2016
Dentistry, Lecture, Lecturer, Anti-histamine drugsSpring 2016
Medicine, Small Group, Facilitator, AAP sectionSpring 2016
2, Medicine, Small Group, Facilitator, Medical pharmacology group studiesFall 2016
Medicine, Lecture, Lecturer, Asthma therapeuticFall 2016
Medicine, Lecture, Lecturer, Anti-histamine drugsFall 2016
Dentistry, Lecture, Lecturer, Asthma therapeuticSpring 2015
Dentistry, Lecture, Lecturer, Anti-histamine drugsSpring 2015
Medicine, Lecture, Lecturer, Anti-histamine drugsFall 2015
Medicine, Lecture, Lecturer, Asthma therapeuticFall 2015
Medicine, Small Group, Facilitator, AAP sectionFall 2015
Medicine, Small Group, Facilitator, AAP sectionSpring 2015
Dentistry, Lecture, Lecturer, Asthma therapeuticSpring 2014
Medicine, Lecture, Lecturer, Asthma therapeuticFall 2014
Dentistry, Lecture, Lecturer, Anti-histamine drugsSpring 2014
Medicine, Lecture, Lecturer, Anti-histamine drugsFall 2014
8 hours, Medicine, Small Group, Facilitator, Medical pharmacology group studiesFall 2014
4, Medicine, Small Group, Facilitator, cardiovascular case studyFall 2014
4 hours, Graduate, Lecture, Lecturer, the mechanisms of drug action-cardiovascular disease and angiogenesisFall 2013
8 hours, Medicine, Small Group, Facilitator, Medical pharmacology group studiesFall 2013
4, Medicine, Small Group, Facilitator, cardiovascular case studyFall 2013
4 hours, Graduate, Lecture, Lecturer, the mechanisms of drug actionFall 2012
Medicine, Small Group, Facilitator, Medical pharmacology group studiesFall 2012
4, Medicine, Small Group, Facilitator, cardiovascular case studyFall 2012
Graduate, Lecture, Lecturer, the mechanisms of drug action-angiogenesisFall 2011
Medicine, Small Group, Facilitator, Medical pharmacology group studiesFall 2011
4, Medicine, Small Group, Facilitator, cardiovascular case studyFall 2011

Directed Student Learning

Dissertation Committee Member, Advised: umesh Bhattarai2020 - Present
Dissertation Committee Member, Effects of beta-amyloid on cerebral hypoperfusion in Alzheimer's diseases
Advised: Xing Fang
2019 - 2023
Dissertation Committee Member, The impact of insulin resistance and inflammation during renal injury associated with prepubertal obesity
Advised: Ubong Ekperikpe
2019 - 2023
Dissertation Committee Chair, Endothelial PHD2 in heart failure
Advised: Quinesha Williams
2019 - 2023
Dissertation Committee Chair, Targeting ferroptosis in mitochondrial cardiomyopathy
Advised: Aubrey C Cantrell
2019 - Present
Supervised Research, Advised: Sumit Sontakke2017 - 2017
Supervised Research, The role of mitochondrial oxidative stress in the pathophysiology of Preeclampsia
Advised: Venkata Ramana Vaka
2014 - 2015
Doctoral Advisory Committee Chair, The Role of Endothelial SIRT3 in Cardiac Hypertrophy and Heart Failure
Advised: Xiaochen He
2012 - 2017
Doctoral Advisory Committee Member, Importance of STAT3 in Hypertension-Induced Remodeling of the Heart
Advised: Fouad Zouein
2012 - 2014
Doctoral Advisory Committee Member, Regulation of Inflammatory JAK-STAT Signaling: Implications for Cardiac Repair and Remodeling
Advised: Carlos Zgheib
2011 - 2013

Fellows supervised

Postdoctoral fellow, Training Faculty, 8 fellows supervised05/2011 - 10/2016