Jian-xiong Chen, MD, FAHA
Professor
Department:
SOM-Pharmacology/Toxicology
Email:
jchen3@umc.edu
Work Phone:
(601) 984-1731
Biography
I am a tenure professor in the department of Pharmacology and Toxicology. I received the M.D. and a master’s degree in pharmacology from Central South University of China. I completed the join PhD program at Southern Illinois University school of Medicine and Central south university. I then continued postdoctoral training in pathology at Vanderbilt University Medical Center. I served as an assistant professor in Pathology, and became associate professor of Pediatrics at Vanderbilt University from 2002-2010. I joined the University of Mississippi Medical Center as an associate professor at Department of Pharmacology and Toxicology in 2011. I am Fellow of American Heart Association (AHA) and member of American Physiology Society. I have served as a grant reviewer committee of NIH, AHA and British Medical Research Council. I have been a part of a very successful research team that have been well-funded by NIH and AHA. My current research interesting is focus to understanding the intracellular molecular mechanisms that regulate coronary microvascular dysfunction, heart failure with preserved ejection fraction (HFpEF) and diabetic cardiomyopathy, then, to develop novel gene therapies for the treatment devastating heart failure. I am the author of 83 peer-reviewed publications and currently funded by National Heart, Lung and Blood Institute. I serves as Editor of Journal of cardiovascular pharmcology.
Education
| Vanderbilt University Medical Center, Postdoctoral Fellow, pathology | 2001 |
| Henan Medical University, MS, pharmacology | 1990 |
| Hunan Medical University, MD, Medicine | 1985 |
Current Positions
| Professor, School of Medicine | 07/2018 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Pharmacology / Toxicology | 2011 - 07/2018 |
| Associate Professor, vanderbilt, School of Medicine, Department of Pediatrics | 2010 - 2011 |
| Assistant Professor, vanderbilt, School of Medicine, Department of Pathology | 2002 - 2010 |
| Department Chair, Hengyang Medical College, School of Medicine | 1992 - 03/1996 |
| Associate Professor, Hengyang Medical College, School of Medicine | 1992 - 03/1996 |
| Assistant Professor, Hengyang Medical college, School of Medicine | 07/1985 - 07/1987 |
Sponsored Program Funding
| Extramural, P53 acetylation in microvascular rarefaction and heart failure, NHLBI | 12/2024 - 11/2028 |
| Extramural, Inactivation of Sirt3-mediated ferroptosis in the heart of Friedreich’s ataxia, NHLBI | 12/2024 - 11/2028 |
| Extramural, Notch3 in coronary microvascular dysfunction and diastolic dysfunction of diabetes, NHLBI | 12/2024 - 11/2028 |
| Extramural, p53 acetylation in microvascular rarefaction and heart failure, NHLBI | 09/2022 - 08/2023 |
| Extramural, Endothelial PHD2 in hypertensive vascular remodeling, NHLBI/NIGMS | 09/2021 - 06/2025 |
| Extramural, Altered Coronary Endothelial-Pericyte Interactions in Diabetes, NHLBI | 10/2020 - 09/2024 |
| Intramural, Altered Coronary Endothelial-Pericyte Interactions in Diabetes, UMMC | 10/2019 - 09/2020 |
| Extramural, Coronary microvascular rarefaction in diabetic/obese heart, NHLBI | 03/2017 - 02/2021 |
| Intramural, coronary microvascular rarefaction in diabetic/obese heart, UMMC | 10/2016 - 09/2017 |
| Extramural, Regulation of vascular maturation/regression in diabetes, NIH/NHLBI | 07/2010 - 03/2016 |
| Extramural, Functional Role of Angiopoietin-2 in Diabetic Heart, NIH/NIDDK | 04/2006 - 03/2010 |
| Extramural, Angiopoietins/Tie-2 and Diabetic Impaired Myocardial Angiogenesis, American Heart Association | 07/2005 - 06/2007 |
| Extramural, Hsp90/Client Protein Interactions in the Newborn Lung, NIH/NHLBI | 04/2005 - 03/2009 |
| Extramural, Effects of Hypoxia on the Coronary Microcirculation, NIH/NHLBI | 06/2000 - 05/2005 |
Publications
Letter | |
| Chen JX, Chen ST, Tao YK, Cardiac pericyte is promising target for ischemic heart diseases: Role of Notch3. International journal of cardiology, 2017 Nov 1;246:57 | 2017 |
Journal Article | |
| Chen JX, Wu HX, Wang Y The role of endotoxin in the bronchial hyperreactivity formation Chinese Medical Journal. 1994; 74(1):38-9, 64 | |
| Chen JX, Cao YS Protection ammonium glycyrrhizanate against endotoxin-induced bronchial hyperreactivity. Chinese Journal of Pharmacology and Toxicology, 1994, 8(3):235-236. | |
| Chen JX, Cao YS. Effect ammonium glycyrrhizanate against endotoxin-induced bronchial hyperreactivity-in relation to beta-cAMP system. Chinese Traditional and Herbal Drugs, 1994, 1(1):17-18. | |
| Chen JX, Tang XQ, Zhu BY, Liao DF. The mechanism of exogenous oxygen free radicals induced vasospasm of isolated basilar artery. Chinese Journal Arteriosclerosis, 1994, 2(2):88-91. | |
| Chen JX, Liao DF, Yu L, Xiao GL, Zhu BY, Tang XQ. Protective effect of captopril on electrolyzed perfusion solution induced vasospasm of isolated basilar artery. Chinese Journal of Pharmacology and Toxicology, 1995, 9(1):44-46. | |
| Chen JX, Liao DF, Tang XQ, Yu L, Zeng H, Cao JG. Protection of Gypenosides against oxygen free radical induced vasospasm of isolated rabbit basilar artery. Chinese Traditional and Herbal Drugs, 1997, 28(4):219-221. | |
| Liao DF, Chen JX, Huang HL, Tang XQ, Cao JG and Yu L. Correlation between the protection of probucol on injury of endothelial cells by free radicals and the activity of nitric oxide Chinese Journal Arteriosclerosis, 1994, 2(2):67-71. | |
| Wan Y, Weng SA, Chen JX, Wu HX, Cao YS. Effects of estradiol on asthma of guinea pigs and its relationship to beta-adrenergic receptors. Chinese Pharmacological Bulletin, 1993, 9(4):295-297. | |
| Xiao GL, Liao DF, Chen JX, Yu L. Protective effect of gypenosides on OFR-induced damage of relaxing capacity of rabbit thoracic aortae in vitro. Chinese Pharmacological Bulletin, 1994, 10(2):136-138. | |
| Li LX, Yu L, Chen JX, Liao DF, Cao JG, Chen LX, Huang HL and Zhu BY. Oxidized low density lipoprotein promotion of adhesion of monocytes to endothelial cells in vitro. Chinese Journal Arteriosclerosis, 1996, 4(4):272-275. | |
| He X, Cantrell AC, Williams QA, Gu W, Chen Y, Chen JX, Zeng H, p53 Acetylation Exerts Critical Roles in Pressure Overload-Induced Coronary Microvascular Dysfunction and Heart Failure in Mice. Arteriosclerosis, thrombosis, and vascular biology, 2024 Apr;44(4):826-842 | 2024 |
| Cantrell AC, Zeng H, Chen JX, The Therapeutic Potential of Targeting Ferroptosis in the Treatment of Mitochondrial Cardiomyopathies and Heart Failure. Journal of cardiovascular pharmacology, 2024 Jan 1;83(1):23-32 | 2024 |
| He X, Williams QA, Cantrell AC, Besanson J, Zeng H, Chen JX, TIGAR Deficiency Blunts Angiotensin-II-Induced Cardiac Hypertrophy in Mice. International journal of molecular sciences, 2024 Feb 19;25(4) | 2024 |
| Pan L, He X, Xu R, Bhattarai U, Niu Z, do Carmo J, Sun Y, Zeng H, Clemmer JS, Chen JX, Chen Y, Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance. GeroScience, 2024 Aug;46(4):3945-3956 | 2024 |
| Cantrell AC, Besanson J, Williams Q, Hoang N, Edwards K, Bishop GR, Chen Y, Zeng H, Chen JX, Ferrostatin-1 specifically targets mitochondrial iron-sulfur clusters and aconitase to improve cardiac function in Sirtuin 3 cardiomyocyte knockout mice. Journal of molecular and cellular cardiology, 2024 Jul;192:36-47 | 2024 |
| Bhattarai U, Xu R, He X, Pan L, Niu Z, Wang D, Zeng H, Chen JX, Clemmer JS, Chen Y, High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure. Redox biology, 2024 Oct;76:103325 | 2024 |
| Liu B, Zeng H, Su H, Williams QA, Besanson J, Chen Y, Chen JX, Endothelial Cell-Specific Prolyl Hydroxylase-2 Deficiency Augments Angiotensin II-Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice. Journal of the American Heart Association, 2024 Aug 20;13(16):e035769 | 2024 |
| Chen JX, Zhang J, Chen Y, Zeng H, Knockout of Sirtuin 3 in endothelial cells impairs endothelial-dependent relaxation and myogenic response in mice. Physiological reports, 2024 Oct;12(20):e70060 | 2024 |
| Chen JX, Li L, Cantrell AC, Williams QA, Zeng H, High Glucose Activates Prolyl Hydroxylases and Disrupts HIF-α Signaling via the P53/TIGAR Pathway in Cardiomyocyte. Cells, 2023 Mar 31;12(7) | 2023 |
| Su H, Cantrell AC, Chen JX, Gu W, Zeng H, SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation. Cells, 2023 May 19;12(10) | 2023 |
| He X, Cantrell AC, Williams QA, Gu W, Chen Y, Chen JX, Zeng H, P53 Acetylation Exerts Critical Roles In Pressure Overload Induced Coronary Microvascular Dysfunction and Heart Failure. bioRxiv : the preprint server for biology, 2023 Feb 9; | 2023 |
| He X, Zeng H, Cantrell AC, Williams QA, Chen JX, Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure. Journal of cellular physiology, 2022 Aug;237(8):3317-3327 | 2022 |
| He X, Cantrell AC, Williams QA, Chen JX, Zeng H, TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury. Physiological reports, 2022 Apr;10(8):e15234 | 2022 |
| Li L, Zeng H, He X, Chen JX, Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism. Journal of the American Heart Association, 2021 Feb;10(5):e018913 | 2021 |
| Su H, Cantrell AC, Zeng H, Zhu SH, Chen JX, Emerging Role of Pericytes and Their Secretome in the Heart. Cells, 2021 Mar 4;10(3) | 2021 |
| He X, Zeng H, Cantrell AC, Chen JX, Regulatory role of TIGAR on endothelial metabolism and angiogenesis. Journal of cellular physiology, 2021 Nov;236(11):7578-7590 | 2021 |
| Yang HX, Zhang M, Long SY, Tuo QH, Tian Y, Chen JX, Zhang CP, Liao DF, Cholesterol in LDL receptor recycling and degradation. Clinica chimica acta; international journal of clinical chemistry, 2020 Jan;500:81-86 | 2020 |
| Zeng H, He X, Chen JX, Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload-Induced Heart Failure. Journal of the American Heart Association, 2020 Jun 2;9(11):e015895 | 2020 |
| Su H, Zeng H, Liu B, Chen JX, Sirtuin 3 is essential for hypertension-induced cardiac fibrosis via mediating pericyte transition. Journal of cellular and molecular medicine, 2020 Jul;24(14):8057-8068 | 2020 |
| Zhao Y, Zeng H, Liu B, He X, Chen JX, Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury. American journal of physiology. Renal physiology, 2020 Aug 1;319(2):F345-F357 | 2020 |
| Feng X, Su H, He X, Chen JX, Zeng H, SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis. Cells, 2020 Nov 20;9(11) | 2020 |
| Su H, Zeng H, He X, Zhu SH, Chen JX, Histone Acetyltransferase p300 Inhibitor Improves Coronary Flow Reserve in SIRT3 (Sirtuin 3) Knockout Mice. Journal of the American Heart Association, 2020 Sep 15;9(18):e017176 | 2020 |
| Zeng H, He X, Chen JX, A Sex-Specific Role of Endothelial Sirtuin 3 on Blood Pressure and Diastolic Dysfunction in Female Mice. International journal of molecular sciences, 2020 Dec 21;21(24) | 2020 |
| Ning J, Zhao C, Chen JX, Liao DF, Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK). Biochemical and biophysical research communications, 2019 Jun 18;514(1):92-97 | 2019 |
| Tang M, Huang Z, Luo X, Liu M, Wang L, Qi Z, Huang S, Zhong J, Chen JX, Li L, Wu D, Chen L, Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy. Free radical biology & medicine, 2019 Apr;134:445-457 | 2019 |
| He L, Zhou Q, Huang Z, Xu J, Zhou H, Lv D, Lu L, Huang S, Tang M, Zhong J, Chen JX, Luo X, Li L, Chen L, PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions. Journal of cellular physiology, 2019 Jun;234(6):8668-8682 | 2019 |
| He X, Zeng H, Chen JX, Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease. Journal of cellular physiology, 2019 Mar;234(3):2252-2265 | 2019 |
| Zeng H, Chen JX, Sirtuin 3, Endothelial Metabolic Reprogramming, and Heart Failure With Preserved Ejection Fraction. Journal of cardiovascular pharmacology, 2019 Oct;74(4):315-323 | 2019 |
| He X, Zeng H, Roman RJ, Chen JX, Inhibition of prolyl hydroxylases alters cell metabolism and reverses pre-existing diastolic dysfunction in mice. International journal of cardiology, 2018 Dec 1;272:281-287 | 2018 |
| Tao YK, Zeng H, Zhang GQ, Chen ST, Xie XJ, He X, Wang S, Wen H, Chen JX, Notch3 deficiency impairs coronary microvascular maturation and reduces cardiac recovery after myocardial ischemia. International journal of cardiology, 2017 Jun 1;236:413-422 | 2017 |
| Wang S, Zeng H, Chen ST, Zhou L, Xie XJ, He X, Tao YK, Tuo QH, Deng C, Liao DF, Chen JX, Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. Journal of cellular and molecular medicine, 2017 Sep;21(9):1967-1978 | 2017 |
| Sun SW, Tong WJ, Guo ZF, Tuo QH, Lei XY, Zhang CP, Liao DF, Chen JX, Curcumin enhances vascular contractility via induction of myocardin in mouse smooth muscle cells. Acta pharmacologica Sinica, 2017 Oct;38(10):1329-1339 | 2017 |
| He X, Zeng H, Chen ST, Roman RJ, Aschner JL, Didion S, Chen JX, Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. Journal of molecular and cellular cardiology, 2017 Nov;112:104-113 | 2017 |
| Qin L, Zhu N, Ao BX, Liu C, Shi YN, Du K, Chen JX, Zheng XL, Liao DF, Caveolae and Caveolin-1 Integrate Reverse Cholesterol Transport and Inflammation in Atherosclerosis. International journal of molecular sciences, 2016 Mar 22;17(3):429 | 2016 |
| Zeng H, He X, Tuo QH, Liao DF, Zhang GQ, Chen JX, LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. Scientific reports, 2016 Feb 12;6:20931 | 2016 |
| Zhang CP, Tian Y, Zhang M, Tuo QH, Chen JX, Liao DF, IDOL, inducible degrader of low-density lipoprotein receptor, serves as a potential therapeutic target for dyslipidemia. Medical hypotheses, 2016 Jan;86:138-42 | 2016 |
| He X, Zeng H, Chen JX, Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia. International journal of cardiology, 2016 Jul 15;215:349-57 | 2016 |
| Wang S, Zeng H, Xie XJ, Tao YK, He X, Roman RJ, Aschner JL, Chen JX, Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. Oncotarget, 2016 Sep 13;7(37):58848-58861 | 2016 |
| Sun S, Wen J, Qiu F, Yin Y, Xu G, Li T, Nie J, Xiong G, Zhang C, Liao D, Chen J, Tuo Q, Identification of the C-terminal domain of Daxx acts as a potential regulator of intracellular cholesterol synthesis in HepG2 cells. Biochemical and biophysical research communications, 2016 Nov 4;480(1):139-145 | 2016 |
| Zeng H, Vaka VR, He X, Booz GW, Chen JX, High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. Journal of cellular and molecular medicine, 2015 Aug;19(8):1847-56 | 2015 |
| Hou X, Zeng H, He X, Chen JX, Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes. Journal of cellular and molecular medicine, 2015 Jan;19(1):53-61 | 2015 |
| Hou X, Zeng H, Tuo QH, Liao DF, Chen JX, Apelin Gene Therapy Increases Autophagy via Activation of Sirtuin 3 in Diabetic Heart. Diabetes research (Fairfax, Va.), 2015 Oct;1(4):84-91 | 2015 |
| Zeng H, He X, Hou X, Li L, Chen JX, Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3. American journal of physiology. Heart and circulatory physiology, 2014 Feb 15;306(4):H585-97 | 2014 |
| Li L, Zeng H, Chen JX, Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction. American journal of physiology. Heart and circulatory physiology, 2012 Sep 1;303(5):H605-18 | 2012 |
| Chen JX, O'Mara PW, Poole SD, Brown N, Ehinger NJ, Slaughter JC, Paria BC, Aschner JL, Reese J, Isoprostanes as physiological mediators of transition to newborn life: novel mechanisms regulating patency of the term and preterm ductus arteriosus. Pediatric research, 2012 Aug;72(2):122-8 | 2012 |
| Chen JX, Zeng H, Reese J, Aschner JL, Meyrick B, Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model. American journal of physiology. Heart and circulatory physiology, 2012 Feb 15;302(4):H1003-12 | 2012 |
| Tuo QH, Xiong GZ, Zeng H, Yu HD, Sun SW, Ling HY, Zhu BY, Liao DF, Chen JX, Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition. Acta pharmacologica Sinica, 2011 Jan;32(1):45-51 | 2011 |
| Chen JX, Stinnett A, Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice. Diabetes, 2008 Dec;57(12):3335-43 | 2008 |
| Chen JX, Stinnett A, Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity. Laboratory investigation; a journal of technical methods and pathology, 2008 Dec;88(12):1316-28 | 2008 |
| Chen JX, Stinnett A, Disruption of Ang-1/Tie-2 signaling contributes to the impaired myocardial vascular maturation and angiogenesis in type II diabetic mice. Arteriosclerosis, thrombosis, and vascular biology, 2008 Sep;28(9):1606-13 | 2008 |
| Tuo QH, Zeng H, Stinnett A, Yu H, Aschner JL, Liao DF, Chen JX, Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis. American journal of physiology. Heart and circulatory physiology, 2008 Jun;294(6):H2547-57 | 2008 |
| Chen JX, Zeng H, Tuo QH, Yu H, Meyrick B, Aschner JL, NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation. American journal of physiology. Heart and circulatory physiology, 2007 Apr;292(4):H1664-74 | 2007 |
| Chen JX, Zeng H, Lawrence ML, Blackwell TS, Meyrick B, Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase. American journal of physiology. Heart and circulatory physiology, 2006 Oct;291(4):H1563-72 | 2006 |
| Jiang P, Yan PK, Chen JX, Zhu BY, Lei XY, Yin WD, Liao DF, High density lipoprotein 3 inhibits oxidized low density lipoprotein-induced apoptosis via promoting cholesterol efflux in RAW264.7 cells. Acta pharmacologica Sinica, 2006 Feb;27(2):151-7 | 2006 |
| Chen JX, Chen Y, DeBusk L, Lin W, Lin PC, Dual functional roles of Tie-2/angiopoietin in TNF-alpha-mediated angiogenesis. American journal of physiology. Heart and circulatory physiology, 2004 Jul;287(1):H187-95 | 2004 |
| Chen JX, Meyrick B, Hypoxia increases Hsp90 binding to eNOS via PI3K-Akt in porcine coronary artery endothelium. Laboratory investigation; a journal of technical methods and pathology, 2004 Feb;84(2):182-90 | 2004 |
| Chen JX, Lawrence ML, Cunningham G, Christman BW, Meyrick B, HSP90 and Akt modulate Ang-1-induced angiogenesis via NO in coronary artery endothelium. Journal of applied physiology (Bethesda, Md. : 1985), 2004 Feb;96(2):612-20 | 2004 |
| Chen JX, Berry LC, Christman BW, Meyrick B, Glutathione mediates LPS-stimulated COX-2 expression via early transient p42/44 MAPK activation. Journal of cellular physiology, 2003 Oct;197(1):86-93 | 2003 |
| Chen JX, Berry LC Jr, Christman BW, Tanner M, Myers PR, Meyrick BO, NO regulates LPS-stimulated cyclooxygenase gene expression and activity in pulmonary artery endothelium. American journal of physiology. Lung cellular and molecular physiology, 2001 Mar;280(3):L450-7 | 2001 |
| Chen JX, Berry LC, Tanner M, Chang M, Myers RP, Meyrick B, Nitric oxide donors regulate nitric oxide synthase in bovine pulmonary artery endothelium. Journal of cellular physiology, 2001 Jan;186(1):116-23 | 2001 |
| Chen JX, Zeng H, Chen X, Su CY, Lai CC, Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage. Pharmacological research, 2001 Jan;43(1):63-9 | 2001 |
| Su CY, Chong KY, Chen J, Ryter S, Khardori R, Lai CC, A physiologically relevant hyperthermia selectively activates constitutive hsp70 in H9c2 cardiac myoblasts and confers oxidative protection. Journal of molecular and cellular cardiology, 1999 Apr;31(4):845-55 | 1999 |
| Chen JX, Chen WZ, Huang HL, Chen LX, Xie ZZ, Zhu BY, Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998 Jul;19(4):359-63 | 1998 |
| Liao DF, Lu N, Lei LS, Yu L, Chen JX, Effects of gypenosides on mouse splenic lymphocyte transformation and DNA polymerase II activity in vitro. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995 Jul;16(4):322-4 | 1995 |
| Zeng H, Chen JX, Conditional knockout of prolyl hydroxylase domain protein 2 attenuates high fat-diet-induced cardiac dysfunction in mice. PloS one, 2014;9(12):e115974 | |
| Zeng H, Li L, Chen JX, Loss of Sirt3 limits bone marrow cell-mediated angiogenesis and cardiac repair in post-myocardial infarction. PloS one, 2014;9(9):e107011 | |
| Li L, Zeng H, Hou X, He X, Chen JX, Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction. PloS one, 2013;8(9):e71041 | |
| Zeng H, Li L, Chen JX, Overexpression of angiopoietin-1 increases CD133+/c-kit+ cells and reduces myocardial apoptosis in db/db mouse infarcted hearts. PloS one, 2012;7(4):e35905 | |
| Chen JX, Tuo Q, Liao DF, Zeng H, Inhibition of protein tyrosine phosphatase improves angiogenesis via enhancing Ang-1/Tie-2 signaling in diabetes. Experimental diabetes research, 2012;2012:836759 | |
| Li LX, Chen JX, Liao DF, Yu L, Probucol inhibits oxidized-low density lipoprotein-induced adhesion of monocytes to endothelial cells by reducing P-selectin synthesis in vitro. Endothelium : journal of endothelial cell research, 1998;6(1):1-8 | |
| Zeng H, Chen JX, Microvascular Rarefaction and Heart Failure With Preserved Ejection Fraction. Frontiers in cardiovascular medicine, 2019;6:15 | |
| Zhou LY, Zeng H, Wang S, Chen JX, Regulatory Role of Endothelial PHD2 in the Hepatic Steatosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018;48(3):1003-1011 | |
| Li TP, Sun SW, Xiong GZ, Qiu F, Yang DM, Sun SY, Xie XJ, Liao DF, Chen JX, Tuo QH, Direct Interaction of Daxx and Androgen Receptor Is Required for Their Regulatory Activity in Cholesterol Biosynthesis. Pharmacology, 2021;106(1-2):29-36 | |
| Bhattarai U, He X, Xu R, Liu X, Pan L, Sun Y, Chen JX, Chen Y, IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression. Frontiers in immunology, 2023;14:1105664 | |
| He X, Xu R, Pan L, Bhattarai U, Liu X, Zeng H, Chen JX, Hall ME, Chen Y, Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling. Frontiers in immunology, 2023;14:1215855 | |
Book Chapter | |
| Chen JX, Zeng H, Chen X, Su CY, Lai CC. Heme oxygenase, Ginkgo biloba extract and its terpenoids protect myocytes against oxidative injury. In: Heme Oxygenase in Biology and Medicine. NG Abraham, ed., 2002, pp. 399-408. | |
Presentations
| Poster Presentation, Deficiency Of Sirtuin 3 In Endothelium Reduces Endothelial-Dependent Relaxation And Impairs Myogenic Response In Coronary And Middle Cerebral Arteries Of Mice, AHA | 11/2023 |
| Poster Presentation, Endothelial Phd2 Deficiency Promotes Angiotensin-Ii-Induced Arterial Stiffness And Coronary Microvascular Dysfunction, North American Vascular Biology | 10/2023 |
| Poster Presentation, Treatment with PFKFB3 inhibitor potentially improves diastolic function and arterial stiffness in PHD2ECKO mice, APS summit | 04/2023 |
| Poster Presentation, Potential role of Ferrostatin-1 as a mitochondrial-targeting agent for the treatment of mitochondrial cardiomyopathy, APS summit | 04/2023 |
| Poster Presentation, Ferrostatin-1 Ameliorates Cardiac Dysfunction in a Cardiomyocyte-Specific SIRTUIN 3 Knockout Mouse Model (Excellent Post Award), Hypertension, AHA | 09/2022 |
| Poster Presentation, Regulatory Role Of Endothelial Phd2 On Hypertensive Arterial Stiffness And Vascular Calcification, Vascular Discovery, AHA | 05/2022 |
| Poster Presentation, Novel Regulatory Role of SIRT3 on Cardiomyocyte Mitochondrial Frataxin and Ferroptosis, EB meeting | 05/2022 |
| Platform Presentations, Deficiency of Sirtuin 3 disrupts endothelial glucose metabolism and sensitizes pressure-overload induced heart failure | 11/2019 |
| Poster Presentation, Deficiency of sirtuin 3 accentuates angiotensin II-induced arterail stiffness/myocardial fibrosis and hypertension, EB Meeting | 04/2019 |
| Poster Presentation, regulatory role of endothelial sirt3 on blood pressure and diastolic dysfunction in a female mice., Hypertension, AHAH | 09/2018 |
| Poster Presentation, ablation of endothelial sirt3 exacerbates pressure overload-induced heart failure, BCVS, AHA | 08/2018 |
| Poster Presentation, Sirtuin 3 attenuates diabetic cardiomyopathy via suppression of p53 acetylation and regulating cardiomyocyte metabolism, Experimental Biology, San Diego | 04/2018 |
| Poster Presentation, Deletion of endothelial Sirt3 causes diastolic dysfunction, AHA council on hypertension, San Francisco, CA | 09/2017 |
| Poster Presentation, Treatment with Prolyl Hydroxylase Inhibitor Reverses Pre-Existing Diastolic Dysfunction in the Aged SIRT3 Knockout Mice, 2017 Experimental Biology in Chicago, Chicago, IL | 04/2017 |
| State/Local Invited Seminars/Lectures, New perspective of Angiopoietins/Tie-2 system in Sepsis, Fushan Hospital, Guang Dong, P.R. China | 05/2016 |
| State/Local Invited Seminars/Lectures, Emerging role of Sirtuin 3 in EC metabolism and diastolic dysfunction, Human University of Chinese Medicine, P.R. China | 05/2016 |
| Poster Presentation, Deletion of Endothelial Sirt3 Causes Coronary Microvascular Dysfunction and HFpEF., Experimental Biology, San Diego, CA | 04/2016 |
| Regional Invited Seminars/Lectures, Emerging role of Sirtuin 3 in EC metabolism and angiogenesis”., University of Southern Illinois, School of Medicine, Department of Microbiology and Biochemistry, Springfield, IL | 09/2015 |
| National and International Invited Seminars/Lectures, New perspective of Angiopoietins/Tie-2 system in Sepsis, Human University of Chinese Medicine, P.R. China., Changsha | 05/2015 |
| National and International Invited Seminars/Lectures, Mechanisms of impairment of myocardial angiogenesis in type II diabetes, University of Beijing Medical Center, Department of Physiology and Physiopathology., Beijing | 09/2014 |
| National and International Invited Seminars/Lectures, New perspective of Angiopoietins/Tie-2 system in Sepsis, Summit of international critical care 2014, Beijing | 09/2014 |
| Platform Presentations, SIRT3 Deficiency Impairs Hypoxic Signaling, Reprograms Basal Glycolytic Metabolism and Exacerbates Myocardial Ischemic Injury., Experimental Biology, Boston, MA | 03/2014 |
| Platform Presentations, Sirt3 is essential for apelin-gene therapy mediated cardiac repair in post-myocardial infarction of diabetes., High blood pressure Research Scientific sessions, New orleans | 09/2013 |
| Poster Presentation, Sirt3 regulates oxygen sensors and blood vessel formation in the heart., High Blood Pressure Research (HBPR), New Orleans, LA | 09/2013 |
| State/Local Invited Seminars/Lectures, Mechanisms of impairment of myocardial angiogenesis in type II diabetes, University of Mississippi Medical Center, Department of Biochemical Science, Jackson, MS. | 12/2012 |
| Poster Presentation, Apelin-13 Increases Myocardial Progenitor Cells and Improves Myocardial Remodeling of Post-myocardial, Hypertension council meeting, New orlean | 09/2012 |
| Poster Presentation, Regulation Of Sirt3 And Autophagy By Bone Marrow Cells Therapy Improves Cardiac Repair In Post-myocardial Infarction Mice., AHA meeting, Dallas | 07/2012 |
| Poster Presentation, Apelin Reduces Myocardial Infarction Size and Promotes Angiogenesis by Increasing SDF-1/CXCR4 and AKT/eNOS/VEGF pathways, AHA meeting, Dallas | 07/2012 |
| Poster Presentation, Ang-1 reduces myocardial infarction via upregulation of SDF-1/CXCR4 and recruiting hematopoietic progenitor cells in the diabetic db/db mouse model., AHA, Orlando, FL | 11/2011 |
| Regional Invited Seminars/Lectures, Angiopoietins/Tie-2 system in diabetic complications, University of Southern Mississippi, Department of Biological Science, Hattiesburg, MS | 11/2011 |
| Poster Presentation, Overexpression of angiopoietin-2 promotes myocardial fibrosis and rarefaction in diabetic db/db mouse model., EB meeting, Washington, DC | 04/2011 |
| State/Local Invited Seminars/Lectures, Angiopoietins/Tie-2 in diabetic infarcted heart, University of Mississippi Health Center, Department of Physiology& Biophysics, Jackson, MS. | 03/2011 |
| Regional Invited Seminars/Lectures, Angiopoietins/Tie-2 system in diabetic vascular complications, Department of Pharmacology, University of Mississippi medical Center, Jackson, MS | 07/2010 |
| Regional Invited Seminars/Lectures, Angiopoietins/Tie-2 system and diabetic abnormal angiogenesis, Department of Pharmacology and Physiology, University of Missouri, Columbia, MO | 05/2010 |
| State/Local Invited Seminars/Lectures, NADPH oxidase and diabetic angiogenesis, Beijing University Medical Center, Beijing, PR China | 07/2008 |
| Regional Invited Seminars/Lectures, Angiopoietins/Tie-2 in diabetic complications, University of South China, Hengyang, Hunan, PR. China. | 07/2008 |
| Poster Presentation, Inhibition of protein tyrosine phosphatase improves hyperglycemic impaired angiogenesis., CIRCULATION, 16: 25-25; 2007 (Poster) | 11/2007 |
| Platform Presentations, Leptin stimulates angiogenesis in myocardial endothelial cells: Involvement of p47phox NADPH oxidase., Experimental Biology meeting, FASEB JOURNAL 21: A180-A180; 2007. | 04/2007 |
| Platform Presentations, High glucose blunts angiopoietin-1 (Ang-1)-induced angiogenesis in myocardial endothelial cells via impairment of Akt and eNOS phosphorylation., FASEB JOURNAL 21: A130-A131; 2007. | 04/2007 |
| Platform Presentations, Hypoxia/reoxygenation-induced myocardial angiogenesis: Role of NADPH oxidase derived reactive oxygen species (ROS), AHA meeting, CIRCULATION 114: 155-155; 2006. | 11/2006 |
| State/Local Invited Seminars/Lectures, Angiogenesis and cardiovascular diseases, University of South China, Hengyang, Hunan, PR. China. | 06/2006 |
| Platform Presentations, Role of NADPH oxidase-derived reactive oxygen species (ROS) in angiopoietin-1-induced angiogenesis, Experimental biology meeting, FASEB JOURNAL 18: A385-A385; 2004. | 03/2004 |
| Platform Presentations, Hypoxia increases heat shock protein 90 binding (Hsp90) to endothelial nitric oxide synthase (eNOS) via a P13-Akt pathway in porcine coronary artery endothelium (PCAEC) ., Experimental Biology Meeting; San Diego, FASEB JOURNAL 17: A805-A805; 2003 | 04/2003 |
Honors, Awards, and Recognition
| Excellence in Research Award,Golden Level., The University of Mississippi Medical Center | 2013 |
| Excellence in Research Award, Silver Level., The University of Mississippi Medical Center | 2012 |
| Excellence in Research Award,Bronze Level., The University of Mississippi Medical Center | 2011 |
| Achievement Award in Science and Technology, Ministry of Science and Technology of Hunan Province, P. R. China | 1999 |
| Achievement Award in Cardiovascular Research, Bureau of Medicine and Hygiene of Hunan Province, P. R. China | 1999 |
| Recipient of Excellent Award in Teaching, Education Commissioner of P.R. China | 1994 |
| Recipient of Excellent Award in Teaching, Education Commissioner of Hunan province, P.R. China | 1992 |
Professional Membership and Service
| North American Vascular Biology Organization, Member | 2023 - Present |
| American Heart Association, Member | 2001 - Present |
| American Physiological Society, Member | 2001 - Present |
Committee Service
| P&T committee, Member | 2018 - Present |
| Research day, Member | 2016 - 2016 |
| Strategic planning/COBRE/PPG committee, Member | 2016 - Present |
| Professional Education committee, Member | 2013 - Present |
| Graduate Program Committee, Member | 2012 - Present |
| Department Faculty recruitment committee, Member | 2012 - Present |
Other Service
| Editor | 05/2024 - Present |
| Pilot grant | 09/2023 - 09/2023 |
| Nature Reviews Cardiology | 06/2023 - 06/2023 |
| CARDIOVASCULAR DIFFERENTIATION AND DEVELOPMENT STUDY SECTION, NIH | 02/2023 - 02/2023 |
| Ad Hoc reviewer for Special Emphasis Panel/Scientific Review Group ZRG1 F10C-C | 05/2022 - 05/2022 |
| Ad hoc reviewer for NIH Special Emphasis Panel (SEP), ZRG1 CVRS B_02. | 07/2021 - 07/2021 |
| Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review | 07/2020 - 07/2020 |
| cardiac group grant review | 07/2020 - Present |
| Pilor grant | 09/2019 - 09/2019 |
| Chair of EB meeting section: Diabetes: A metabolic Karma | 04/2019 - 04/2019 |
| Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review | 06/2018 - 06/2018 |
| Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review | 10/2017 - 10/2017 |
| Ad hoc reviewer for NIH Special Emphasis Panel/PPG Review, member | 06/2015 - 06/2015 |
| Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member | 05/2015 - 05/2015 |
| Journal of cardiovascular pharmacology | 2015 - Present |
| Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member | 02/2014 - 02/2014 |
| Journal of Contemporary Diabetes Research | 2014 - Present |
| Diabetes Research-open Journal | 2014 - 12/2017 |
| Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member | 10/2013 - 11/2013 |
| Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member | 05/2013 - 05/2013 |
| Ad hoc reviewer for NIH Special Emphasis Panel/Scientific Review, member | 01/2013 - 01/2013 |
| Cardiovascular Genetics and Systems Medicine | 2013 - Present |
| Ad hoc reviewer for NIH-Cell, Molecular, and Computational Biology, member | 11/2012 - 11/2012 |
| Ad hoc reviewer for Medical Research Council (United Kingdom), member | 05/2012 - 05/2012 |
| Regular Reviewer for Vascular Wall Biology Committee of American Heart Association (Vas Wall Bio AAGI BSc2), member | 05/2011 - 10/2013 |
| Reviewer: Journal of cardiovascular pharmacology, JAHA, Cell Physiol Biochem, oncotarget, Acta Pharmacological Sin; Acta Biochim Biophys Sin; American Journal of Pathology; European Journal of Pharmacology; Journal of Thrombosis and Heamostasis; Canadian Journal of Physiology and Pharmacology, Clinical and Experimental Pharmacology and Physiology; Journal of Pediatric Endocrinology and Metabolism; Arterioscler Thromb Vasc Biol; PLoS ONE; Diabetes; Biochemical and Biophysical Research Communications, experimental cell research | 2011 - Present |
Teaching Experience
| Dentistry, Lecture, Lecturer, Dental Pharmacology | Annual 2018-2024 - 2024 |
| 1, Medicine, Lecture, Lecturer, Medical Pharmacology | Annual 2018-2024 |
| 1, Graduate, Lecture, Lecturer, the mechanisms of drug action | Annual 2018-2024 |
| 1, Graduate, Lecture, Lecturer, Pharmacology mechanisms | Annual 2018-2024 |
| 1, Dentistry, Small Group, Course Presenter, Review Session | Annual 2018-2024 |
| 1, Medicine, Small Group, Course Presenter, Medical pharmacology Review Session | Annual 2018-2024 |
| 1, Dentistry, Course, Course Director, dental pharmacology | Annual 2017-2024 |
| Dentistry, Lecture, Lecturer, anti-histamine drugs | Spring 2017 |
| Dentistry, Lecture, Lecturer, Asthma therapeutic | Spring 2017 |
| Dentistry, Course, Course Director, Dental pharmacology | Spring 2017 |
| Graduate, Lecture, Lecturer, Approaches to study Control of Angiogenesis | Spring 2017 |
| 4, Medicine, Small Group, Facilitator, autonomic drug responses | Fall 2017 - 2017 |
| 1, Medicine, Lecture, Lecturer, Histamine and H1 receptor antagonists | Fall 2017 - 2017 |
| 1, Medicine, Lecture, Lecturer, Drug used in the treatment of asthma | Fall 2017 - 2017 |
| 4, Medicine, Small Group, Facilitator, cardiovascular case study | Fall 2017 |
| 2, Graduate, Lecture, Lecturer, angiogenesis & vessel rarefication II | Fall 2017 - 2017 |
| Dentistry, Lecture, Lecturer, Asthma therapeutic | Spring 2016 |
| Dentistry, Lecture, Lecturer, Anti-histamine drugs | Spring 2016 |
| Medicine, Small Group, Facilitator, AAP section | Spring 2016 |
| 2, Medicine, Small Group, Facilitator, Medical pharmacology group studies | Fall 2016 |
| Medicine, Lecture, Lecturer, Asthma therapeutic | Fall 2016 |
| Medicine, Lecture, Lecturer, Anti-histamine drugs | Fall 2016 |
| Dentistry, Lecture, Lecturer, Asthma therapeutic | Spring 2015 |
| Dentistry, Lecture, Lecturer, Anti-histamine drugs | Spring 2015 |
| Medicine, Lecture, Lecturer, Anti-histamine drugs | Fall 2015 |
| Medicine, Lecture, Lecturer, Asthma therapeutic | Fall 2015 |
| Medicine, Small Group, Facilitator, AAP section | Fall 2015 |
| Medicine, Small Group, Facilitator, AAP section | Spring 2015 |
| Dentistry, Lecture, Lecturer, Asthma therapeutic | Spring 2014 |
| Medicine, Lecture, Lecturer, Asthma therapeutic | Fall 2014 |
| Dentistry, Lecture, Lecturer, Anti-histamine drugs | Spring 2014 |
| Medicine, Lecture, Lecturer, Anti-histamine drugs | Fall 2014 |
| 8 hours, Medicine, Small Group, Facilitator, Medical pharmacology group studies | Fall 2014 |
| 4, Medicine, Small Group, Facilitator, cardiovascular case study | Fall 2014 |
| 4 hours, Graduate, Lecture, Lecturer, the mechanisms of drug action-cardiovascular disease and angiogenesis | Fall 2013 |
| 8 hours, Medicine, Small Group, Facilitator, Medical pharmacology group studies | Fall 2013 |
| 4, Medicine, Small Group, Facilitator, cardiovascular case study | Fall 2013 |
| 4 hours, Graduate, Lecture, Lecturer, the mechanisms of drug action | Fall 2012 |
| Medicine, Small Group, Facilitator, Medical pharmacology group studies | Fall 2012 |
| 4, Medicine, Small Group, Facilitator, cardiovascular case study | Fall 2012 |
| Graduate, Lecture, Lecturer, the mechanisms of drug action-angiogenesis | Fall 2011 |
| Medicine, Small Group, Facilitator, Medical pharmacology group studies | Fall 2011 |
| 4, Medicine, Small Group, Facilitator, cardiovascular case study | Fall 2011 |
Directed Student Learning
| Dissertation Committee Member, Advised: umesh Bhattarai | 2020 - Present |
| Dissertation Committee Member, Effects of beta-amyloid on cerebral hypoperfusion in Alzheimer's diseases Advised: Xing Fang | 2019 - 2023 |
| Dissertation Committee Member, The impact of insulin resistance and inflammation during renal injury associated with prepubertal obesity Advised: Ubong Ekperikpe | 2019 - 2023 |
| Dissertation Committee Chair, Endothelial PHD2 in heart failure Advised: Quinesha Williams | 2019 - 2023 |
| Dissertation Committee Chair, Targeting ferroptosis in mitochondrial cardiomyopathy Advised: Aubrey C Cantrell | 2019 - Present |
| Supervised Research, Advised: Sumit Sontakke | 2017 - 2017 |
| Supervised Research, The role of mitochondrial oxidative stress in the pathophysiology of Preeclampsia Advised: Venkata Ramana Vaka | 2014 - 2015 |
| Doctoral Advisory Committee Chair, The Role of Endothelial SIRT3 in Cardiac Hypertrophy and Heart Failure Advised: Xiaochen He | 2012 - 2017 |
| Doctoral Advisory Committee Member, Importance of STAT3 in Hypertension-Induced Remodeling of the Heart Advised: Fouad Zouein | 2012 - 2014 |
| Doctoral Advisory Committee Member, Regulation of Inflammatory JAK-STAT Signaling: Implications for Cardiac Repair and Remodeling Advised: Carlos Zgheib | 2011 - 2013 |
Fellows supervised
| Postdoctoral fellow, Training Faculty, 8 fellows supervised | 05/2011 - 10/2016 |