Zhengwei Cai

Zhengwei Cai

PROFESSOR EMERITUS

Education

Oregon State University, PhD, Fish Physiology1988

Academic Appointments or Other Previous Appointments

School of Medicine, Department of Pediatrics

Sponsored Program Funding

Extramural, Perinatal infection, cytokines and brain injury, NIH, NINDS07/2005 - 06/2011
Extramural, Perinatal hypoxia-ischemia, glutamate receptors, and NOS, NIH, NICHD05/2003 - 04/2009

Publications

Journal Article

Fan LW, chen RF, Mitchell HJ, Lin RCS, Simpson KL, Rhodes PG, Cai Z. alpha-phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced brain injury and improves neurological reflexes and early sensorimotor behavioral performance in juvenile rat. J Neurosci Res, 2008; 86: 3536-3547.2008
Fan LW, Mitchell HJ, Tien LT, Zheng B, Pang Y, Rhodes PG, Cai Z. alpha-phenyl-n-tert-butyl-nitrone reduces lipopolysaccharide-induced white matter injury in the neonatal rat brain. Dev Neurobiol, 2008; 68: 365-378.2008
Zhu M-Y, Wang W-P, Cai Z, Regunathan S, Ordway G. Exogenous agmatine has neuroprotective effects against restraint-induced structural changes in the rat brain. Eur J Neurosci. 2008; 27:1320-13322008
Fan L-W, Tien L-T, Mitchell HJ, Rhodes PG, Cai Z. -phenyl-n-tert-butyl-nitrone ameliorates hippocampal injury and improves learning and memory in juvenile rats following neonatal exposure to lipopolysaccharide. Eur J Neurosci., 2008; 27: 1475-1484.2008
Fan L-W, Mitchell HJ, Rhodes PG, Cai Z. -phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced neuronal injury in the neonatal rat brain. Neurosci., 2008; 151: 737-744.2008
Pang Y, Zheng B, Fan L-W, Rhodes PG, Cai Z. IGF-1 protects oligodendrocyte progenitors against TNF--induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway. Glia, 2007; 55: 1099-11072007

Presentations

Poster Presentation, Activated microglia induces oligodendrocyte progenitor cell death through two phases: an acute damage mediated by nitric oxide and a delayed injury by cytokine., Society for Neuroscience, Washington, DC11/2008
Poster Presentation, Adverse effect of serotonin on developing oligodendrocytes: a possible association with autism., Society for Neuroscience, Washington, DC11/2008
Poster Presentation, Alpha-phenyl-n-tert-butyl-nitrone reduces lipopolysaccharide-induced neuronal injury in the neonatal rat brain., Society for Neuroscienc, Washington, DC11/2008
Poster Presentation, Disturbance of motor behavior and dopaminergic injury in the adult rat brain following neonatal exposure to lipopolysaccharide., Society for Neuroscience, Washintong, DC11/2008
Poster Presentation, Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in the neonatal rats., Society for Neuroscience, Washington, DC11/2008
Poster Presentation, Post-treatment with erythropoietin does not protect developing oligodendrocytes from hypoxic-ischemic injury in the neonatal rat brain., Society for Neuroscience, Washington, DC11/2008
National and International Invited Seminars/Lectures, Perinatal inflammation and brain injury., Charles P. Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC.05/2008

Honors, Awards, and Recognition

Excellence in Research Award, Gold Level, UMC
Excellence in Research Award, Bronze Level, UMC

Professional Membership and Service

NIH, DBD study section, Member2006 - 2010

Committee Service

Animal Care and Use, Member2006 - 2010

Other Service

Pediatrics Departmental Research Committee, member06/2007 - Present