Gary "Reid" R. Bishop, PhD

Biography

After teaching undergraduates for over 20-years Dr. Bishop retired from undergraduate higher education in 2022 as Professor and Chair of the Department of Chemistry & Physics and Division Chair of Science & Mathematics at Belhaven University.

He has since moved to the Department of Pharmacology and Toxicology at the University of Mississippi Medical Center as Professor and Director of the Mass Spectrometry Core Facility (MSCF).

Mass Spectrometry Core Facility (MSCF)
As Director of the Mass Spectrometry Core Facility (MCSF), Dr. Bishop utilizes advanced spectroscopic and biophysical methods to facilitate collaborative discovery across the University of Mississippi Medical Center. The goal of the MSCF is the development of novel diagnostics and therapeutics of cardiovascular, inflammatory, autoimmune, infectious, and metastatic (cancer) disease. At the center of this work is the development of targeted metabolomic and proteomic biomarker panels from body fluid or tissue biopsy. Dr. Bishop primarily utilizes electrospray ionization (ESI) multiple reaction monitoring (MRM) tandem mass spectrometry (LC-MS/MS, LC-MRM/MS) and magnetic resonance (x-band EPR, high-field pulsed NMR) spectroscopies. He also coordinates departmental efforts in the detection and quantitation of reactive oxygen species (ROS) and nitric oxide as mediators of disease and tissue damage.

Previous and current collaborative projects of the MSCF with investigators across the University of Mississippi Medical Center include development of targeted biomarker proteomic, lipidomic, and metabolomic panels for:
1) high blood pressure
2) pre-eclampsia
3) autoimmune disorders
4) inflammation
5) SARS2 COVID response
6) renal carcinoma
7) multiple myeloma
8) renal damage
9) neurohormonal alterations
10) type-2 diabetes
11) blood coagulation
12) heart failure
13) mitochondrial dysfunction
14) drug pharmacokinetics and pharmacodynamics
15) pneumococcal infection
16) post-translational modifications of proteins
17) sex steroid hormonal imbalance
18) reactive oxygen and nitrogen species-mediated tissue damage
19) serum protein interactions
20) therapeutic monoclonal antibody (MAb) aggregation, stability, and antigen recognition
21) STEM cell biology
22) peptide endocrinology
23) detection of reactive oxygen species (ROS) and 24) molecular dynamics of spin-labeled therapeutic peptides
25) development of serum mimics

Research Interests

As Professor of Pharmacology/Toxicology, Dr Bishop’s personal research interest is broadly in the development of advanced bioanalytical and biophysical instrumental methods (spectroscopic, calorimetric, hydrodynamic) for the determination of the energetics of biomolecular recognition in therapeutic systems. This involves the development of detailed quantitative structure thermodynamic activity relationships (QSTAR) that explore the interconnectivity between target protein and nucleic acid receptors and libraries of ligands. These energetic, kinetic, and structural details govern the formation of on- and off-target molecular complexes that lie at the heart of all pharmacological, cellular, and physiological processes and are critical for structure-based drug design strategies. Systems of historical and current interest in the Bishop laboratory include the following.

1) green chemistry
2) DNA aptamer folding and ligand binding
3) napthylquinoline interactions with diverse DNA/RNA targets
4) lanthanide/actinide interactions with substituted crown ethers.
5) degradation of energetic materials.
6) chiral protein recognition of substituted warfarin serum albumins
7) therapeutic monoclonal antibody aggregation and interactions with serum proteins
8) energetics and conformational changes during antibody:antigen recognition
9) RNA riboswitch Interactions with amino acid derivatives.
10) recognition of peptides by non-canonical DNA structures
11) role of long non-coding RNA (lncRNA) open reading frames (ORF’s) in renal cancer.

Education

Current Positions

Academic Appointments or Other Previous Appointments

Honors, Awards, and Recognition

Professional Membership and Service

Community Service